casein-kinase-ii and lysophosphatidic-acid

Lysophosphatidic acid (LPA) is an important lipid molecule for signal transduction in cell proliferation. Although the effects of LPA on vascular smooth muscle (VSM) cell growth have been reported previously, the underlying mechanisms of its action are not fully understood. The present study was undertaken to investigate the effects of some inhibitors of different protein kinases and other molecular targets on LPA-induced DNA synthesis as well as gene expression in the aortic VSM cells. The DNA synthesis was studied by the [

Topics: Animals; Casein Kinase II; Cell Line; Cell Proliferation; Endothelin-1; Gene Expression Regulation, Enzymologic; Lysophospholipids; Muscle, Smooth, Vascular; Protein Kinase C; Rats; Receptors, Lysophosphatidic Acid; Ribosomal Protein S6 Kinases, 70-kDa; RNA, Messenger; Type C Phospholipases