casein-kinase-ii has been researched along with furan* in 1 studies
1 other study(ies) available for casein-kinase-ii and furan
| Article | Year |
|---|---|
Design, synthesis and biological evaluation of new embelin derivatives as CK2 inhibitors.
A new series of furan embelin derivatives was synthesized and characterized as ATP-competitive CK2 inhibitors. The new compounds were efficiently synthesized using a multicomponent approach from embelin (1), aldehydes and isonitriles through a Knoevenagel condensation/Michael addition/heterocyclization. Several compounds with inhibitory activities in the low micromolar or even submicromolar were identified. The most active derivative was compound 4l (2-(tert-butylamino)-3-(furan-3-yl)-5-hydroxy-6-undecylbenzofuran-4,7-dione) with an IC Topics: Adenosine Triphosphate; Benzoquinones; Binding, Competitive; Casein Kinase II; Drug Design; Drug Evaluation, Preclinical; Furans; Humans; MCF-7 Cells; Molecular Docking Simulation; Protein Kinase Inhibitors; Structure-Activity Relationship | 2020 |