casein-kinase-ii has been researched along with alternariol* in 1 studies
1 other study(ies) available for casein-kinase-ii and alternariol
| Article | Year |
|---|---|
Alternaria toxins as casein kinase 2 inhibitors and possible consequences for estrogenicity: a hybrid in silico/in vitro study.
Emerging mycotoxins produced by Alternaria spp. were previously reported to exert cytotoxic, genotoxic, but also estrogenic effects in human cells. The involved mechanisms are very complex and not fully elucidated yet. Thus, we followed an in silico target fishing approach to extend knowledge on the possible biological targets underlying the activity of alternariol, taken as the signature compound of Alternaria toxins. Combining ligand-based screening and structure-based modeling, the ubiquitous casein kinase 2 (CK2) was identified as a potential target for the compound. This result was validated in a cell-free in vitro CK2 activity assay, where alternariol inhibited CK2 with an IC Topics: Alternaria; Casein Kinase II; Cell Line, Tumor; Estrogen Receptor alpha; Estrogen Receptor beta; Humans; Lactones; Ligands; Molecular Docking Simulation; Mycotoxins; Protein Binding; Protein Conformation; Protein Kinase Inhibitors; Structure-Activity Relationship | 2020 |