caryophyllene and 4-allyl-2-6-dimethoxyphenol

Hydrodistilled oil obtained from the stem bark of Myrica esculenta Buch. Ham. ex D. Don (yield 0.3%) was analysed by capillary GC and GC-MS. The volatile oil consisted mainly of n-hexadecanol (25.2%), eudesmol acetate (21.9%), palmitic acid (11.6%), cis-β-caryophyllene (8.7%), n-pentadecanol (7.7%) and n-octadecanol (7.6%). The oil was found to be a potential antimicrobial agent against Bacillus pumilus, Staphylococcus aureus, Staphylococcus epidermidis, Escherichia coli, Pseudomonas aeruginosa, Candida albicans, Aspergillus niger and Saccharomyces cerevisiae. The essential oil exhibited significant topical anti-inflammatory activity compared to standard drug in Swiss albino mice ear.

Topics: Administration, Topical; Animals; Anti-Bacterial Agents; Anti-Infective Agents; Anti-Inflammatory Agents, Non-Steroidal; Aspergillus niger; Candida albicans; Drug Evaluation, Preclinical; Eugenol; Fatty Alcohols; Gas Chromatography-Mass Spectrometry; Mice; Myrica; Oils, Volatile; Palmitic Acid; Polycyclic Sesquiterpenes; Pseudomonas aeruginosa; Sesquiterpenes; Staphylococcus aureus