carubicin and carminomycinone

carubicin has been researched along with carminomycinone* in 4 studies

Other Studies

4 other study(ies) available for carubicin and carminomycinone

ArticleYear
[Determination of carminomycin in its preparations by high-performance liquid chromatography].
    Antibiotiki i khimioterapiia = Antibiotics and chemoterapy [sic], 1988, Volume: 33, Issue:8

    A three component system for separating a mixture of carminomycin, carminomycinone and 13-dihydrocarminomycinone by HPLC was developed. Spherisorb ODS Column, 4.6 X 250 mm, the particle size of 10 micron was used. The impact of the mobile phase composition, temperature during chromatography and buffer solution pH on the capacity factors K' for every of the above compounds was studied. For determining purity of carminomycin dosage forms the procedure with an external standard was applied. The procedure provides routine quantitative assay of carminomycin hydrochloride dosage forms.

    Topics: Buffers; Carubicin; Chromatography, High Pressure Liquid; Daunorubicin; Hydrogen-Ion Concentration

1988
Synthesis of 2'-deoxy-L-fucopyranosylcarminomycinone and -epsilon-pyrromycinone as well as 2'-deoxy-D-erythro-pentopyranosyldaunomycinone, -carminomycinone, and -epsilon-pyrromycinone.
    Journal of medicinal chemistry, 1981, Volume: 24, Issue:1

    Treatment of di-O-acetyl-2-deoxy-L-fucopyranosyl bromide with carminomycinone and epsilon-pyrromycinone in the presence of mercuric bromide and mercuric cyanide afforded 3',4'-diO-acetyl-2'-deoxy-L-fucopyranosylcarminomycinone and -epsilon-pyrromycinone. Similarly, when di-O-acetyl-2-deoxy-D-erythrho-pentopyranosyl chloride was treated with daunomycinone, carminomycinone and epsilon-pyrromycinone, the di-O-acetyl derivatives of the anthracyclinone glycosides were obtained. Deacetylation of the previous acetates with sodium methoxide afforded 2'-deoxy-L-fucopyranosylcarminomycinone and -epsilon-pyrromycinone, as well as 2'-deoxy-D-erythro-pentopyranosyldaunomycinone, -carminomycinone, and -epsilon-pyrromycinone. 2'-Deoxy-L-fucopyranosylcarminomycinone was found to be more active than carminomycin at higher dosages on L1210.

    Topics: Animals; Anthracyclines; Antibiotics, Antineoplastic; Bacteria; Carubicin; Chemical Phenomena; Chemistry; Mice; Naphthacenes

1981
Microbial transformations of natural antitumor agents. 13. Conversions of 13-blocked anthracyclinones.
    The Journal of antibiotics, 1980, Volume: 33, Issue:7

    Microbial transformation experiments were performed using 13-ketone-blocked daunomycinone derivatives which were converted into the corresponding carminomycinone derivatives by microbial O-demethylation.

    Topics: Antibiotics, Antineoplastic; Carubicin; Chemical Phenomena; Chemistry; Daunorubicin; Fermentation; Mitosporic Fungi; Naphthacenes

1980
[Synthesis and properties of carminomycinone derivatives].
    Antibiotiki, 1977, Volume: 22, Issue:12

    The possibility of chemical modification of carminomycinone-aglycone (II) of carminomicin, a side product in the antibiotic production was studied. The methyl group C-14 was functionilized by introducing the bromine atom and performing a number of exchange reactions with the bromine atom. It was found that under definite conditions (1. 1 equiv. Br2in dioxane, 20 degrees, 24 hours) carminomycinone (II) was subjected to selective bromination into the side acetyl group with formation of 14-bromcarminomycinone (III). On interaction with anhydrous potassium acetate 14-bromcarminomycinone (III) yield 14-acetoxycarminomycinone (IV). In its turn the latter compound (IV) easily hydrolized to 14-oxycarminomycinone (V) in treatment with aqueous alkali or acid. 14-oxycarminomycinone (V) was also prepared with a high yield (80 per cent) by direct alkaline hydrolysis of 14-bromcarminomycinone (III) in treatment with 0.1N solution of sodium carbonate in a mixture of dioxane and water. The structure of 14-substituted derivatives of carminomycinone was proved by analytical and spectral data and confirmed by their transformation. Thus, according to the data of mass-spectrometry 14-oxycarminomycinone (V) had a molecular weight of 400 c. u. In treatment with an excess of acetic anhydride in pyridine it formed a hexa-acetyl derivative, i.e. 4, 6, 7, 9, 11, 14-hexa-acetyl-14-oxycarminomycinone (VI). The aglycones (III-V) prepared by us may serve a starting material in chemical synthesis, as well as biosynthesis of semi-synthetic preparations of the carminomycin series.

    Topics: Antibiotics, Antineoplastic; Bromine; Carubicin; Hydroxylation; Mass Spectrometry; Spectrophotometry, Ultraviolet

1977