carnitine and tryptophan

carnitine has been researched along with tryptophan in 33 studies

Research

Studies (33)

TimeframeStudies, this research(%)All Research%
pre-19903 (9.09)18.7374
1990's1 (3.03)18.2507
2000's4 (12.12)29.6817
2010's14 (42.42)24.3611
2020's11 (33.33)2.80

Authors

AuthorsStudies
Artursson, P; Bergström, CA; Hoogstraate, J; Matsson, P; Norinder, U; Pedersen, JM1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A1
McDaniel, HG1
Bamji, MS; Khan-Siddiqui, L; Murthy, SN; Vijayasarathy, C1
Bakerman, S; Gourley, WK; Haas, CD1
Rohr, F; Warman, ML; Yannicelli, S1
Prats Viñas, J1
Contera, SA; de Planque, MR; Lemaître, V; Ryan, JF; Watts, A1
Augustyniak, A; Skrzydlewska, E1
Duggan, G; Nazyrova, A; Schicho, R; Shaykhutdinov, R; Storr, M; Vogel, HJ1
Ashmore, C; Chakrapani, A; Daly, A; Gokmen-Ozel, H; Hendriksz, C; MacDonald, A; Preece, MA; Vijay, S1
Igarashi, K; Katsumi, T; Nishise, Y; Okumoto, K; Saito, K; Saito, T; Sato, C; Shao, L; Soga, T; Sugimoto, M; Tomita, K; Tomita, M; Ueno, Y; Watanabe, H1
Hang, W; Huang, Q; Liu, L; Martin, FL; Mu, X; Shen, H; Tian, M; Xia, Y; Zhang, J1
Hu, C; Li, J; Liu, X; Xie, P; Xu, G; Zhang, Y; Zhao, J; Zhao, X; Zheng, P; Zhou, J1
Bao, Y; Gao, P; Hong, CS; Jia, W; Luo, P; Tu, Y; Wei, L; Xu, G; Yin, P; Yu, H; Zhang, P; Zhao, X; Zhuang, Z1
Ärlestig, L; Rantapää-Dahlqvist, S; Surowiec, I; Trygg, J1
Esteras, R; Fernandez-Prado, R; Gonzalez-Parra, E; Gracia-Iguacel, C; Ortiz, A; Perez-Gomez, MV; Sanchez-Niño, MD; Sanz, AB1
Chadeau-Hyam, M; Chatzi, L; Keski-Rahkonen, P; Kogevinas, M; Nawrot, T; Pizzi, C; Plusquin, M; Richiardi, L; Robinot, N; Robinson, O; Scalbert, A; Sunyer, J; Vermeulen, R; Vineis, P; Vrijheid, M1
Auriola, S; Hanhineva, K; Heinonen, S; Jääskeläinen, T; Jokkala, J; Kärkkäinen, O; Laivuori, H; Lehtonen, M; Litonius, K1
Argyopoulos, CP; Bayliss, GP; Cao, G; Chen, DQ; Chen, H; Chen, L; Cheng, XH; Guo, Y; Kang, H; Li, XR; Liu, D; Ma, SX; Mao, JR; Meng, MX; Samuels, DC; Shang, YQ; Su, W; Vaziri, ND; Wang, M; Ye, F; Yu, H; Yu, XY; Zhang, L; Zhang, Y; Zhao, J; Zhao, S; Zhao, YY; Zhuang, S1
Console, L; Giangregorio, N; Indiveri, C; Pistillo, M; Scalera, V; Tonazzi, A1
Berge, RK; Bjørndal, B; Lindquist, C; Lund, A; Nygård, O; Skorve, J; Slettom, G; Svardal, A1
Caldez, MJ; Choi, H; Coppola, V; Eisenhaber, F; Goh, CMF; Gopinathan, L; Jones, OS; Kaldis, P; Kanagasundaram, Y; Kien, YL; Kurochkin, IV; Low, KN; Maurer-Stroh, S; Niska-Blakie, J; Ong, CB; Pfeiffenberger, E; Tessarollo, L1
Clark, C; Delorenzi, M; Gallart-Ayala, H; Henry, H; Ivanisevic, J; Konz, I; Mehl, F; Oikonomidi, A; Peyratout, G; Popp, J; Teav, T; van der Velpen, V1
Amatobi, KM; Fekete, A; Helfrich-Förster, C; Horn, M; Mueller, MJ; Rieger, D; Schäbler, S; Wegener, C1
Chu, SH; Clish, C; Costenbader, KH; Cui, J; Deane, KD; Edison, JD; Feser, ML; Karlson, EW; Kelmenson, LB; Lasky-Su, J; Lu, B; Mewshaw, EA; Moss, L; Sparks, JA; Speyer, CB; Tedeschi, SK1
Becker, LB; Choi, J; Choudhary, RC; Hayashida, K; Kim, J; Kim, N; Nishikimi, M; Shoaib, M; Stevens, JF; Yagi, T; Yin, T1
Akpan, IJ; Buehler, PW; Cendali, FI; D'Alessandro, A; Francis, RO; Gamboni, F; Hod, EA; Hudson, KE; Kahn, S; Katneni, U; Moriconi, C; Nemkov, T; Reisz, JA; Roh, D; Spitalnik, SL; Tanaka, K; Thangaraju, K; Thomas, T; Valk, JE; Wei, AZ; Zimring, JC1
Alvarenga, AC; Appel, RM; Arima, EC; Ayache, R; Budib, MA; D'Amora, P; Diaz, RS; Evans, SS; Júnior, SS; Martins, WG; Nagourney, RA; Palma, AM; Pontes, HBD; Salzgeber, MB; Silva, FC; Silva, IDCG; Silva, NLF; Silva, RMS1
Abraldes, JG; Alessandria, C; Beuers, U; Campion, D; Caraceni, P; Carol, M; Davis, MM; de Wit, K; Durand, F; Francoz, C; Ginès, P; Jiménez, C; Juanola, A; Kamath, PS; Kazankov, K; Lozano, JJ; Ma, AT; Mookerjee, RP; Morales-Ruiz, M; Napoleone, L; Piano, S; Pose, E; Sidorova, J; Solà, E; Tonon, M; Trebicka, J; Uschner, F; Vargas, V; Watson, H; Zaccherini, G1
Melander, O; Ottosson, F; Smith, E; Yan, Y1
Ai, C; Shen, C; Song, S; Tong, Y; Wang, L; Wang, S; Yan, C1
Bertinato, J; Hendry, A; Kenney, L; Xiao, CW1

Reviews

2 review(s) available for carnitine and tryptophan

ArticleYear
Nutrition support for glutaric acidemia type I.
    Journal of the American Dietetic Association, 1994, Volume: 94, Issue:2

    Topics: Amino Acid Metabolism, Inborn Errors; Carnitine; Child; Child, Preschool; Dietary Proteins; Female; Food, Formulated; Glutarates; Glutaryl-CoA Dehydrogenase; Humans; Infant; Infant, Newborn; Lysine; Male; Mitochondria; Oxidoreductases; Oxidoreductases Acting on CH-CH Group Donors; Riboflavin; Tryptophan

1994
Nutrients Turned into Toxins: Microbiota Modulation of Nutrient Properties in Chronic Kidney Disease.
    Nutrients, 2017, May-12, Volume: 9, Issue:5

    Topics: Cardiovascular Diseases; Carnitine; Choline; Diet; Gastrointestinal Microbiome; Humans; Methylamines; Micronutrients; Oxalates; Phosphates; Phosphatidylcholines; Renal Insufficiency, Chronic; Tryptophan; Tyrosine

2017

Trials

2 trial(s) available for carnitine and tryptophan

ArticleYear
Dynamics of serum metabolites in patients with chronic hepatitis C receiving pegylated interferon plus ribavirin: a metabolomics analysis.
    Metabolism: clinical and experimental, 2013, Volume: 62, Issue:11

    Topics: Adult; Aged; Antiviral Agents; Area Under Curve; Betaine; Carnitine; Chromatography, Liquid; Drug Therapy, Combination; Female; Glycine; Hepatitis C, Chronic; Humans; Interferons; Male; Metabolomics; Middle Aged; Polyethylene Glycols; Principal Component Analysis; Ribavirin; Tandem Mass Spectrometry; Treatment Outcome; Tryptophan; Viral Load

2013
Treatment With Simvastatin and Rifaximin Restores the Plasma Metabolomic Profile in Patients With Decompensated Cirrhosis.
    Hepatology communications, 2022, Volume: 6, Issue:5

    Topics: Acute-On-Chronic Liver Failure; Carnitine; Humans; Kynurenine; Liver Cirrhosis; Metabolomics; Rifaximin; Simvastatin; Tryptophan

2022

Other Studies

29 other study(ies) available for carnitine and tryptophan

ArticleYear
Prediction and identification of drug interactions with the human ATP-binding cassette transporter multidrug-resistance associated protein 2 (MRP2; ABCC2).
    Journal of medicinal chemistry, 2008, Jun-12, Volume: 51, Issue:11

    Topics: Administration, Oral; Animals; Antineoplastic Agents; Antipsychotic Agents; Antiviral Agents; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Biological Transport; Cell Line; Computer Simulation; Cytochrome P-450 Enzyme System; Drug-Related Side Effects and Adverse Reactions; Estradiol; Humans; Insecta; Liver; Models, Molecular; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Neoplasm Proteins; Pharmaceutical Preparations; Pharmacology; Structure-Activity Relationship

2008
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
    Chemical research in toxicology, 2010, Volume: 23, Issue:1

    Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship

2010
A comparison of effect of insulin on hepatic metabolites, gluconeogenesis, and ketogenesis.
    The American journal of physiology, 1977, Volume: 233, Issue:1

    Topics: Alanine; Animals; Aspartic Acid; Blood Glucose; Carnitine; Citrates; Decanoic Acids; Fasting; Fatty Acids; Fatty Acids, Nonesterified; Gluconeogenesis; Glucose; Insulin; Ketone Bodies; Lactates; Liver; Liver Glycogen; Malates; Male; Pyruvate Carboxylase; Pyruvates; Rats; Tryptophan

1977
Rise in plasma trimethyllysine levels in humans after oral lysine load.
    The American journal of clinical nutrition, 1987, Volume: 46, Issue:5

    Topics: Administration, Oral; Adult; Carnitine; Humans; Lysine; Male; Time Factors; Tryptophan

1987
Separation of choline from some bases on Dowex columns.
    Analytical biochemistry, 1967, Volume: 19, Issue:1

    Topics: Amines; Betaine; Buffers; Carnitine; Choline; Chromatography, Ion Exchange; Diphenhydramine; Ephedrine; Ethylamines; Indicators and Reagents; Ion Exchange Resins; Quaternary Ammonium Compounds; Spectrophotometry; Thiamine; Tryptamines; Tryptophan

1967
[Glutaric aciduria type I: an organic acidemia without acidosis with severe movement disorders].
    Neurologia (Barcelona, Spain), 2001, Volume: 16, Issue:8

    Topics: Adult; Amino Acid Metabolism, Inborn Errors; Brain Diseases, Metabolic; Carnitine; Child, Preschool; Glutarates; Glutaryl-CoA Dehydrogenase; Humans; Infant; Lysine; Movement Disorders; Oxidoreductases; Oxidoreductases Acting on CH-CH Group Donors; Phenotype; Tryptophan

2001
Unfolding and extraction of a transmembrane alpha-helical peptide: dynamic force spectroscopy and molecular dynamics simulations.
    Biophysical journal, 2005, Volume: 89, Issue:5

    Topics: 1,2-Dipalmitoylphosphatidylcholine; Carnitine; Cell Adhesion; Cell Membrane; Computer Simulation; Hot Temperature; Lipid Bilayers; Microscopy, Atomic Force; Models, Molecular; Molecular Conformation; Peptides; Phosphatidylcholines; Protein Denaturation; Protein Folding; Protein Structure, Secondary; Pyrenes; Spectrophotometry; Spectrum Analysis; Thermodynamics; Tryptophan

2005
L-Carnitine in the lipid and protein protection against ethanol-induced oxidative stress.
    Alcohol (Fayetteville, N.Y.), 2009, Volume: 43, Issue:3

    Topics: Aldehydes; Animals; Antioxidants; Carnitine; Ethanol; Glutathione; Lipid Metabolism; Lipid Peroxidation; Liver; Male; Malondialdehyde; Oxidative Stress; Proteins; Rats; Rats, Wistar; Tryptophan; Tyrosine; Vitamin E

2009
Quantitative metabolomic profiling of serum and urine in DSS-induced ulcerative colitis of mice by (1)H NMR spectroscopy.
    Journal of proteome research, 2010, Dec-03, Volume: 9, Issue:12

    Topics: Animals; Carnitine; Colitis, Ulcerative; Creatine; Dextran Sulfate; Hypoxanthine; Ketone Bodies; Magnetic Resonance Spectroscopy; Metabolomics; Methylamines; Mice; Models, Biological; Principal Component Analysis; Time Factors; Tryptophan

2010
Dietary practices in glutaric aciduria type 1 over 16 years.
    Journal of human nutrition and dietetics : the official journal of the British Dietetic Association, 2012, Volume: 25, Issue:6

    Topics: Adolescent; Adult; Age Factors; Amino Acid Metabolism, Inborn Errors; Biomarkers; Brain Diseases; Brain Diseases, Metabolic; Carnitine; Child; Child, Preschool; Diet, Protein-Restricted; Dietary Proteins; Dietetics; Disabled Persons; Early Diagnosis; Enteral Nutrition; Female; Glucose; Glutaryl-CoA Dehydrogenase; Humans; Lysine; Male; Practice Patterns, Physicians'; Severity of Illness Index; Tryptophan; United Kingdom; Young Adult

2012
Metabolomic analysis reveals a unique urinary pattern in normozoospermic infertile men.
    Journal of proteome research, 2014, Jun-06, Volume: 13, Issue:6

    Topics: Adult; Aspartic Acid; Biomarkers; Carnitine; Humans; Infertility, Male; Leukotriene E4; Male; Metabolome; Metabolomics; Ribonucleosides; ROC Curve; Tryptophan; Xanthines; Young Adult

2014
Discovery and validation of plasma biomarkers for major depressive disorder classification based on liquid chromatography-mass spectrometry.
    Journal of proteome research, 2015, May-01, Volume: 14, Issue:5

    Topics: Adult; Biomarkers; Carnitine; Case-Control Studies; Chromatography, Liquid; Depressive Disorder, Major; Female; Humans; Lipid Metabolism; Logistic Models; Lysophosphatidylcholines; Lysophospholipids; Male; Metabolome; Middle Aged; Phosphatidylethanolamines; Quality of Life; Sensitivity and Specificity; Severity of Illness Index; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Tryptophan

2015
Metabolomics Study of Roux-en-Y Gastric Bypass Surgery (RYGB) to Treat Type 2 Diabetes Patients Based on Ultraperformance Liquid Chromatography-Mass Spectrometry.
    Journal of proteome research, 2016, Apr-01, Volume: 15, Issue:4

    Topics: Adult; Amino Acids; Bile Acids and Salts; Bilirubin; Biomarkers; Carnitine; Chromatography, High Pressure Liquid; Diabetes Mellitus, Type 2; Energy Metabolism; Fatty Acids, Nonesterified; Female; Gastric Bypass; Hippurates; Humans; Indican; Insulin Resistance; Male; Mass Spectrometry; Metabolomics; Middle Aged; Obesity, Morbid; Oxidative Stress; Prognosis; Remission Induction; Treatment Outcome; Tryptophan; Weight Loss

2016
Metabolite and Lipid Profiling of Biobank Plasma Samples Collected Prior to Onset of Rheumatoid Arthritis.
    PloS one, 2016, Volume: 11, Issue:10

    Topics: Adult; Area Under Curve; Arthritis, Rheumatoid; Biological Specimen Banks; Biomarkers; Body Mass Index; Carnitine; Chromatography, High Pressure Liquid; Discriminant Analysis; Fatty Acids; Female; Humans; Least-Squares Analysis; Lipids; Lysophosphatidylcholines; Metabolomics; Middle Aged; Principal Component Analysis; ROC Curve; Tryptophan

2016
Cord Blood Metabolic Signatures of Birth Weight: A Population-Based Study.
    Journal of proteome research, 2018, 03-02, Volume: 17, Issue:3

    Topics: Birth Weight; Carnitine; Chromatography, High Pressure Liquid; Cohort Studies; Docosahexaenoic Acids; Environmental Exposure; Europe; Female; Fetal Blood; Fetal Development; Fetus; Humans; Indoles; Infant, Newborn; Male; Mass Spectrometry; Metabolome; Particulate Matter; Phosphatidylcholines; Pregnancy; Progesterone; Prostaglandins; Reference Standards; Tryptophan; Vitamin A

2018
A Non-Targeted LC-MS Profiling Reveals Elevated Levels of Carnitine Precursors and Trimethylated Compounds in the Cord Plasma of Pre-Eclamptic Infants.
    Scientific reports, 2018, 10-02, Volume: 8, Issue:1

    Topics: Adult; Biomarkers; Carnitine; Case-Control Studies; Chromatography, Liquid; Creatine; Cross-Sectional Studies; Female; Fetal Blood; Humans; Infant, Newborn; Metabolomics; Phosphatidylcholines; Pre-Eclampsia; Pregnancy; Principal Component Analysis; Putrescine; Pyridoxic Acid; Tandem Mass Spectrometry; Tryptophan; Urea

2018
Identification of serum metabolites associating with chronic kidney disease progression and anti-fibrotic effect of 5-methoxytryptophan.
    Nature communications, 2019, 04-01, Volume: 10, Issue:1

    Topics: Acetylcarnitine; Animals; Canavanine; Carnitine; Case-Control Studies; Disease Models, Animal; Disease Progression; Fibrosis; Gene Knock-In Techniques; Gene Knockdown Techniques; Humans; I-kappa B Proteins; Inflammation; Kelch-Like ECH-Associated Protein 1; Kidney; Metabolomics; Mice; NF-E2-Related Factor 2; NF-kappa B; Renal Insufficiency, Chronic; Severity of Illness Index; Signal Transduction; Taurine; Tryptophan; Tryptophan Hydroxylase; Ureteral Obstruction

2019
Tryptophan 224 of the rat mitochondrial carnitine/acylcarnitine carrier is crucial for the antiport mechanism.
    Biochimica et biophysica acta. Bioenergetics, 2019, 09-01, Volume: 1860, Issue:9

    Topics: Amino Acid Sequence; Animals; Antiporters; Aspergillus nidulans; Biological Transport; Carnitine; Carnitine Acyltransferases; Models, Molecular; Mutagenesis, Site-Directed; Mutant Proteins; Mutation; Protein Conformation; Rats; Recombinant Proteins; Sequence Homology; Tryptophan

2019
Increased fatty acid oxidation and mitochondrial proliferation in liver are associated with increased plasma kynurenine metabolites and nicotinamide levels in normolipidemic and carnitine-depleted rats.
    Biochimica et biophysica acta. Molecular and cell biology of lipids, 2020, Volume: 1865, Issue:2

    Topics: Animals; Carnitine; Cell Proliferation; Kynurenine; Lipid Metabolism; Liver; Male; Metabolic Networks and Pathways; Methylhydrazines; Mitochondria; NAD; Niacinamide; Oxidation-Reduction; Peroxisomes; Rats; Tryptophan

2020
Knockout of the non-essential gene SUGCT creates diet-linked, age-related microbiome disbalance with a diabetes-like metabolic syndrome phenotype.
    Cellular and molecular life sciences : CMLS, 2020, Volume: 77, Issue:17

    Topics: Aging; Animals; Anti-Bacterial Agents; Bacteria; Carnitine; Coenzyme A-Transferases; Dietary Supplements; Feces; Gastrointestinal Microbiome; Humans; Kidney; Lipid Metabolism; Liver; Lysine; Metabolic Syndrome; Metabolome; Mice; Mice, Knockout; Obesity; Tryptophan

2020
Systemic and central nervous system metabolic alterations in Alzheimer's disease.
    Alzheimer's research & therapy, 2019, 11-28, Volume: 11, Issue:1

    Topics: Aged; Aged, 80 and over; Alzheimer Disease; Amyloid beta-Peptides; Biomarkers; Brain; Carnitine; Case-Control Studies; Energy Metabolism; Female; Humans; Male; Metabolomics; Middle Aged; Phosphorylation; tau Proteins; Tryptophan

2019
Loss of function in the Drosophila clock gene period results in altered intermediary lipid metabolism and increased susceptibility to starvation.
    Cellular and molecular life sciences : CMLS, 2020, Volume: 77, Issue:23

    Topics: Animals; Biomarkers; Carnitine; Circadian Clocks; Circadian Rhythm; Drosophila melanogaster; Drosophila Proteins; Feeding Behavior; Lipid Metabolism; Lipids; Loss of Function Mutation; Male; Metabolome; Motor Activity; Period Circadian Proteins; Starvation; Stress, Physiological; Tryptophan

2020
Circulating plasma metabolites and risk of rheumatoid arthritis in the Nurses' Health Study.
    Rheumatology (Oxford, England), 2020, 11-01, Volume: 59, Issue:11

    Topics: Adult; Age Factors; Arthritis, Rheumatoid; Body Mass Index; Butyric Acid; Caprylates; Carnitine; Case-Control Studies; Female; Humans; Incidence; Logistic Models; Metabolome; Methionine; Middle Aged; Military Personnel; Nurses; Phosphatidylethanolamines; Prospective Studies; Putrescine; Reproducibility of Results; Risk Factors; Smoking; Spermidine; Tryptophan; United States

2020
Plasma metabolomics supports the use of long-duration cardiac arrest rodent model to study human disease by demonstrating similar metabolic alterations.
    Scientific reports, 2020, 11-12, Volume: 10, Issue:1

    Topics: Animals; Biomarkers; Cardiopulmonary Resuscitation; Carnitine; Disease Models, Animal; Fatty Acids; Heart Arrest; Humans; Kynurenic Acid; Male; Metabolomics; Phospholipids; Rats; Rats, Sprague-Dawley; Severity of Illness Index; Tryptophan

2020
Biological and Clinical Factors Contributing to the Metabolic Heterogeneity of Hospitalized Patients with and without COVID-19.
    Cells, 2021, 09-02, Volume: 10, Issue:9

    Topics: Acute Disease; Adult; Amino Acids; Body Mass Index; Carnitine; Cohort Studies; COVID-19; Fatty Acids; Female; Humans; Kynurenine; Machine Learning; Metabolomics; Middle Aged; Prognosis; Prospective Studies; SARS-CoV-2; Severity of Illness Index; Tryptophan

2021
Towards risk stratification and prediction of disease severity and mortality in COVID-19: Next generation metabolomics for the measurement of host response to COVID-19 infection.
    PloS one, 2021, Volume: 16, Issue:12

    Topics: Adult; Aged; Area Under Curve; Carnitine; Citrulline; COVID-19; Female; Glutamic Acid; Humans; Kynurenine; Male; Metabolome; Metabolomics; Middle Aged; Ornithine; Risk Factors; ROC Curve; SARS-CoV-2; Severity of Illness Index; Tryptophan

2021
The association between plasma metabolites and future risk of all-cause mortality.
    Journal of internal medicine, 2022, Volume: 292, Issue:5

    Topics: Biomarkers; Carnitine; Glutamates; Histidine; Humans; Leucine; Lysine; Metabolomics; Prospective Studies; Tryptophan; Valine

2022
    Food & function, 2023, Jan-23, Volume: 14, Issue:2

    Topics: Animals; Ascophyllum; Betaine; Carnitine; Fatty Acids, Volatile; Gastrointestinal Microbiome; Inflammation; Mice; Polysaccharides; RNA, Transfer; Tryptophan

2023
L-Lysine supplementation affects dietary protein quality and growth and serum amino acid concentrations in rats.
    Scientific reports, 2023, Nov-15, Volume: 13, Issue:1

    Topics: Amino Acids; Animals; Asparagine; Carnitine; Caseins; Diet; Dietary Proteins; Dietary Supplements; Histidine; Leucine; Lysine; Male; Methionine; Ornithine; Racemethionine; Rats; Rats, Sprague-Dawley; Tryptophan; Valine; Weight Gain

2023