carnitine and trimethylamine

carnitine has been researched along with trimethylamine in 41 studies

Research

Studies (41)

Timeframe	Studies, this research(%)	All Research%
pre-1990	2 (4.88)	18.7374
1990's	3 (7.32)	18.2507
2000's	3 (7.32)	29.6817
2010's	17 (41.46)	24.3611
2020's	16 (39.02)	2.80

Authors

Authors	Studies
Ferrari, L; Maccari, F; Pessotto, P; Ramacci, MT	1
Charest, R; Dunn, A	1
Felipo, V; Grisolía, S; Hermenegildo, C; Llsansola, M; Miñana, MD; Montoliu, C	1
Bain, MD; Burns, SP; Chalmers, RA; Holmes, HC; Iles, RA; Kordoni, V; Michelakakis, H; Rafter, JE	1
BEMM, H; ROTZSCH, W; STRACK, E	1
Bain, MA; Evans, AM; Milne, RW	1
Ferrari, ND; Nield, LS	1
Bain, MA; Evans, AM; Faull, R; Milne, RW	1
Haller, RG; Lakoski, S; Malloy, CR; Ren, J; Sherry, AD	1
Baek, HH; Shim, JE	1
Miller, MJ	1
Arduini, A; Lopaschuk, GD; Ussher, JR	1
Bugg, TD; Chen, Y; Crosatti, M; Jameson, E; Rajakumar, K; Schäfer, H; Zhu, Y	1
Hazen, SL; Tang, WH	1
Liu, C; Liu, J; Yin, Y; Zhao, M; Zheng, L; Zhou, J	1
Chmurzynska, A; Malinowska, AM; Szwengiel, A	1
Hegele, RA; Ho, RH; Kim, RB; Leake, BF; Mansell, SE; Morse, BL; Teft, WA; Wilson, A	1
Shimizu, M; Yamazaki, H	1
Grinberga, S; Hartmane, D; Kalnins, G; Sevostjanovs, E; Tars, K	1
Allayee, H; Buffa, JA; Cajka, T; DiDonato, JA; Fiehn, O; Gu, X; Han, Y; Hartiala, JA; Hazen, SL; Hurd, AG; Kerby, RL; Li, L; Li, XS; Lüscher, TF; Nemet, I; Obeid, S; Rey, FE; Roberts, AB; Romano, KA; Shahen, CJ; Skye, SM; Tang, WHW; Wagner, MA; Wang, Z; Wu, Y	1
Chen, Y; Jameson, E; Quareshy, M	1
Bresciani, L; Brighenti, F; Calani, L; Dall'Asta, M; Del Rio, D; Favari, C	1
Bartlett, D; Cody, DB; Copeland, MF; Culley, MK; Dai, HJ; DiDonato, JA; Fu, X; Garcia-Garcia, JC; Gu, X; Hazen, SL; Kirsop, J; Koeth, RA; Lam-Galvez, BR; Levison, BS; Li, L; Li, XS; Tang, WHW; Wang, Z; Wu, Y	1
Chen, PY; Ho, CT; Koh, YC; Li, S; Pan, MH; Wu, JC; Yang, MJ	1
Wu, Q; Yang, X; Zhang, X; Zhao, Y	1
Bordoni, L; Gabbianelli, R; Olek, RA; Sawicka, AK; Szarmach, A; Winklewski, PJ	1
Auger, J; Dahl, WJ; Ford, AL; Hung, WL; Nagulesapillai, V; Suh, JH; Wang, Y	1
García-Cañas, V; Simó, C	1
Aukrust, P; Berge, RK; Dahl, TB; Fevang, B; Halvorsen, B; Holm, K; Hov, JR; Jørgensen, SF; Kummen, M; Macpherson, ME; Mollnes, TE; Otterdal, K; Trøseid, M; Ueland, T	1
Bernieh, D; Cassambai, S; Heaney, LM; Israr, MZ; Jones, DJL; Ng, LL; Salzano, A; Suzuki, T; Yazaki, Y	1
Chen, GY; Chepyala, D; Chiu, HH; Kuo, CH; Kuo, HC; Lu, WH	1
Day-Walsh, P; Kellingray, L; Kroon, PA; Narbad, A; Nemeckova, B; Saha, S; Savva, GM; Shehata, E; Speranza, J	1
Bergström, M; Fagerström, C; Hefni, ME; Lennqvist, T; Witthöft, CM	1
Balskus, EP; Bollenbach, M; Fu, B; Rajakovich, LJ	1
Abecia, L; Anguita, J; Fornari, T; García-Cañas, V; García-Risco, MR; Peña-Cearra, A; Rodríguez, H; Simó, C	1
Anand, N; Chandana, KA; Chidambaram, SB; Kalyan, M; Kanna, PV; Mahalakshmi, AM; Pandi-Perumal, SR; Praveenraj, SS; Sakharkar, MK; Shasthara, P; Sonali, S; Tousif, HA; Vichitra, C; Yang, J	1
Bode, LM; Eggers, M; Jahn, D; Jasper, J; Lubitz, W; Moser, J; Neubauer, K; Piskol, F; Reijerse, E; Slusarenko, A	1
Blanco, R; Daimiel, L; Dávalos, A; Díez-Ricote, L; Micó, V; Ordovás, JM; Ruiz-Valderrey, P; Tomé-Carneiro, J	1
Wang, N; Wu, Q; Yang, X; Zhang, L; Zhao, Y	1
Abe, T; Bhuiya, J; Isomura, M; Kobayashi, H; Nabika, T; Nagai, A; Notsu, Y; Okazaki, R; Sheikh, AM; Shibly, AZ; Yamaguchi, K; Yamasaki, M; Yano, S	1
Lazar, M; Olma, A; Streb, W	1

Reviews

5 review(s) available for carnitine and trimethylamine

Article	Year
Gut microbiota metabolism of L-carnitine and cardiovascular risk. Atherosclerosis, 2013, Volume: 231, Issue:2 Topics: Animals; Atherosclerosis; Cardiovascular Diseases; Carnitine; Diet; Dietary Supplements; Humans; Insulin Resistance; Intestines; Liver; Methylamines; Mice; Microbiota; Muscle, Skeletal; Myocardial Ischemia; Phosphatidylcholines; Risk	2013
The contributory role of gut microbiota in cardiovascular disease. The Journal of clinical investigation, 2014, Volume: 124, Issue:10 Topics: Animals; Atherosclerosis; Cardiovascular Diseases; Carnitine; Choline; Diet; Female; Food; Humans; Intestines; Male; Methylamines; Microbiota; Oxygenases; Phosphatidylcholines	2014
Methodological considerations for the identification of choline and carnitine-degrading bacteria in the gut. Methods (San Diego, Calif.), 2018, 10-01, Volume: 149 Topics: Amino Acid Sequence; Cardiovascular Diseases; Carnitine; Choline; Computational Biology; Diet; Gastrointestinal Microbiome; Humans; Klebsiella pneumoniae; Methylamines; Proteus mirabilis	2018
Dietary bioactive ingredients to modulate the gut microbiota-derived metabolite TMAO. New opportunities for functional food development. Food & function, 2020, Aug-01, Volume: 11, Issue:8 Topics: Betaine; Biological Availability; Carnitine; Choline; Diet; Food Ingredients; Functional Food; Gastrointestinal Absorption; Gastrointestinal Microbiome; Gastrointestinal Tract; Heart Disease Risk Factors; Humans; Liver; Methylamines; Oxygenases	2020
The Role of a Gut Microbial-Derived Metabolite, Trimethylamine N-Oxide (TMAO), in Neurological Disorders. Molecular neurobiology, 2022, Volume: 59, Issue:11 Topics: Betaine; Carnitine; Choline; Flavins; Gastrointestinal Microbiome; Humans; Inflammasomes; Lyases; Methylamines; Mixed Function Oxygenases; Nervous System Diseases; NF-kappa B; NLR Family, Pyrin Domain-Containing 3 Protein	2022

Trials

5 trial(s) available for carnitine and trimethylamine

Article	Year
Disposition and metabolite kinetics of oral L-carnitine in humans. Journal of clinical pharmacology, 2006, Volume: 46, Issue:10 Topics: Administration, Oral; Adult; Area Under Curve; Carnitine; Chromatography, High Pressure Liquid; Diarrhea; Dose-Response Relationship, Drug; Humans; Kidney; Male; Metabolic Clearance Rate; Methylamines; Nausea; Taste Disorders; Vitamin B Complex	2006
Oral L-carnitine: metabolite formation and hemodialysis. Current drug metabolism, 2006, Volume: 7, Issue:7 Topics: Administration, Oral; Adult; Aged; Carnitine; Humans; Kidney Failure, Chronic; Male; Methylamines; Middle Aged; Renal Dialysis	2006
l-Carnitine in omnivorous diets induces an atherogenic gut microbial pathway in humans. The Journal of clinical investigation, 2019, 01-02, Volume: 129, Issue:1 Topics: Animals; Atherosclerosis; Betaine; Carnitine; Clostridiales; Female; Gastrointestinal Microbiome; Humans; Male; Methylamines; Mice; Pilot Projects; Vegans	2019
A Pilot Study on the Effects of l-Carnitine and Trimethylamine-N-Oxide on Platelet Mitochondrial DNA Methylation and CVD Biomarkers in Aged Women. International journal of molecular sciences, 2020, Feb-05, Volume: 21, Issue:3 Topics: Aged; Atherosclerosis; Biomarkers; Blood Platelets; Cardiovascular System; Carnitine; Dietary Supplements; DNA Methylation; DNA, Mitochondrial; Female; Humans; Lipid Metabolism; Methylamines; Middle Aged; Mitochondria; Oxides; Pilot Projects	2020
In older women, a high-protein diet including animal-sourced foods did not impact serum levels and urinary excretion of trimethylamine-N-oxide. Nutrition research (New York, N.Y.), 2020, Volume: 78 Topics: Aged; Carnitine; Clostridiales; Cresols; Cross-Over Studies; Diet, High-Protein; Feces; Female; Gastrointestinal Microbiome; Glutamine; Humans; Indican; Meat; Methylamines; Prebiotics; Probiotics; Sulfuric Acid Esters; Synbiotics	2020

Other Studies

31 other study(ies) available for carnitine and trimethylamine

Article	Year
L-carnitine interference in gas chromatographic determination of total trimethylamine in urine: a novel assay method. Journal of chromatography, 1990, Oct-26, Volume: 532, Issue:1 Topics: Animals; Carnitine; Chromatography, Gas; False Positive Reactions; Methylamines; Rats	1990
Chromatographic separation of choline, trimethylamine, trimethylamine oxide, and betaine from tissues of marine fish. Analytical biochemistry, 1984, Volume: 136, Issue:2 Topics: Animals; Betaine; Carnitine; Choline; Chromatography, Ion Exchange; Fishes; Liver; Methylamines; Muscles; Tissue Extracts	1984
Carnitine and choline derivatives containing a trimethylamine group prevent ammonia toxicity in mice and glutamate toxicity in primary cultures of neurons. The Journal of pharmacology and experimental therapeutics, 1996, Volume: 279, Issue:1 Topics: Ammonia; Animals; Carnitine; Cells, Cultured; Choline; Cycloleucine; Glutamic Acid; Male; Methylamines; Mice; Neurons; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate	1996
Choline and L-carnitine as precursors of trimethylamine. Biochemical Society transactions, 1997, Volume: 25, Issue:1 Topics: Animals; Carnitine; Child, Preschool; Choline; Female; Fishes; Humans; Magnetic Resonance Spectroscopy; Meat; Metabolism, Inborn Errors; Methylamines; Reference Values	1997
[TRIMETHYLAMINE AND TRIMETHYLAMINE OXIDE IN THE URINE AFTER THE ADMINISTRATION OF N-14- AND N-15-(-) CARNITINE]. Acta biologica et medica Germanica, 1963, Volume: 11 Topics: Amines; Body Fluids; Carnitine; Folic Acid; Humans; Hyperthyroidism; Male; Methylamines; Nitrogen; Prostatic Neoplasms; Radioisotopes; Urine; Vitamin B Complex	1963
Smelling like dead fish: a case of trimethylaminuria in an adolescent. Clinical pediatrics, 2006, Volume: 45, Issue:9 Topics: Adolescent; Anti-Infective Agents; Biomarkers; Carnitine; Choline; Creatinine; Humans; Male; Metabolism, Inborn Errors; Methylamines; Nootropic Agents	2006
Dynamic monitoring of carnitine and acetylcarnitine in the trimethylamine signal after exercise in human skeletal muscle by 7T 1H-MRS. Magnetic resonance in medicine, 2013, Volume: 69, Issue:1 Topics: Acetylcarnitine; Adult; Carnitine; Exercise; Female; Humans; Magnetic Resonance Spectroscopy; Male; Methylamines; Middle Aged; Muscle, Skeletal	2013
Determination of trimethylamine in spinach, cabbage, and lettuce at alkaline pH by headspace solid-phase microextraction. Journal of food science, 2012, Volume: 77, Issue:10 Topics: Adsorption; Betaine; Brassica; Carnitine; Choline; Dimethylpolysiloxanes; Gas Chromatography-Mass Spectrometry; Hydrogen-Ion Concentration; Lactuca; Methylamines; Polyvinyls; Reproducibility of Results; Solid Phase Microextraction; Spinacia oleracea; Taste; Temperature	2012
Risk factors for cardiovascular disease: a cautionary tale of diet-microbiome interactions. Journal of the American College of Nutrition, 2013, Volume: 32, Issue:2 Topics: Cardiovascular Diseases; Carnitine; Choline; Diet; Gastrointestinal Tract; Humans; Methylamines; Microbiota; Risk Factors	2013
Carnitine metabolism to trimethylamine by an unusual Rieske-type oxygenase from human microbiota. Proceedings of the National Academy of Sciences of the United States of America, 2014, Mar-18, Volume: 111, Issue:11 Topics: Acinetobacter baumannii; Carnitine; Chromatography, Ion Exchange; Computational Biology; Escherichia coli; Humans; Methylamines; Microbiota; Mutagenesis, Site-Directed; Oxidoreductases; Oxygenases; Spectrophotometry, Ultraviolet	2014
Simultaneous targeted analysis of trimethylamine-N-oxide, choline, betaine, and carnitine by high performance liquid chromatography tandem mass spectrometry. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2016, Nov-01, Volume: 1035 Topics: Animals; Betaine; Carnitine; Choline; Chromatography, High Pressure Liquid; Male; Methylamines; Mice; Mice, Inbred C57BL; Tandem Mass Spectrometry	2016
Dietary, anthropometric, and biochemical factors influencing plasma choline, carnitine, trimethylamine, and trimethylamine-N-oxide concentrations. International journal of food sciences and nutrition, 2017, Volume: 68, Issue:4 Topics: Aged; Body Size; Carnitine; Choline; Diet; Female; Humans; Methylamines; Middle Aged	2017
Identification and Characterization of Trimethylamine-N-oxide Uptake and Efflux Transporters. Molecular pharmaceutics, 2017, 01-03, Volume: 14, Issue:1 Topics: Animals; ATP-Binding Cassette Transporters; Biological Transport; Carnitine; Humans; Male; Membrane Transport Proteins; Methylamines; Mice; Mice, Knockout; Organic Cation Transport Proteins; Oxides; Oxygenases	2017
Human plasma and urinary metabolic profiles of trimethylamine and trimethylamine N-oxide extrapolated using a simple physiologically based pharmacokinetic model. The Journal of toxicological sciences, 2017, Volume: 42, Issue:4 Topics: Administration, Oral; Animals; Carnitine; Humans; In Vitro Techniques; Kidney; Male; Methylamines; Microsomes, Liver; Models, Biological; Rats; Rats, Sprague-Dawley; Risk Assessment	2017
CntA oxygenase substrate profile comparison and oxygen dependency of TMA production in Providencia rettgeri. Journal of basic microbiology, 2018, Volume: 58, Issue:1 Topics: Carnitine; Humans; Methylamines; Microbiota; Oxidation-Reduction; Oxygen; Oxygenases; Providencia; Substrate Specificity	2018
Untargeted metabolomics identifies trimethyllysine, a TMAO-producing nutrient precursor, as a predictor of incident cardiovascular disease risk. JCI insight, 2018, 03-22, Volume: 3, Issue:6 Topics: Aged; Animals; Atherosclerosis; Cardiovascular Diseases; Carnitine; Cholesterol; Choline; Disease Models, Animal; Feces; Female; Gastrointestinal Microbiome; Genome-Wide Association Study; Humans; Lysine; Male; Metabolomics; Methylamines; Mice; Mice, Inbred C57BL; Middle Aged; Nutrients; Risk Factors; Thrombosis	2018
An in vitro exploratory study of dietary strategies based on polyphenol-rich beverages, fruit juices and oils to control trimethylamine production in the colon. Food & function, 2018, Dec-13, Volume: 9, Issue:12 Topics: Adult; Bacteria; Biotransformation; Carnitine; Choline; Colon; Diet; Feces; Female; Fruit and Vegetable Juices; Gastrointestinal Microbiome; Humans; Male; Methylamines; Middle Aged; Oils; Polyphenols; Young Adult	2018
Oolong Tea Extract and Citrus Peel Polymethoxyflavones Reduce Transformation of l-Carnitine to Trimethylamine- Journal of agricultural and food chemistry, 2019, Jul-17, Volume: 67, Issue:28 Topics: Animals; Atherosclerosis; Bacteria; Biotransformation; Camellia sinensis; Carnitine; Citrus; Female; Flavones; Gastrointestinal Microbiome; Gastrointestinal Tract; Humans; Methylamines; Mice; Mice, Inbred C57BL; Plant Extracts; Tumor Necrosis Factor-alpha; Vascular Cell Adhesion Molecule-1	2019
Journal of agricultural and food chemistry, 2019, Nov-27, Volume: 67, Issue:47 Topics: Animals; Bacteria; Carnitine; Gastrointestinal Microbiome; Humans; Interleukin-1; Interleukin-6; Liver; Liver Diseases; Magnoliopsida; Male; Methylamines; Mice; Plant Oils; Seeds	2019
Gut Microbiota-Dependent Trimethylamine N-Oxide Associates With Inflammation in Common Variable Immunodeficiency. Frontiers in immunology, 2020, Volume: 11 Topics: Adult; Bacteria; Bacterial Proteins; Biomarkers; Carnitine; Common Variable Immunodeficiency; Diet; Feces; Female; Gastrointestinal Microbiome; Humans; Immunoglobulin A, Secretory; Inflammation; Lipopolysaccharides; Male; Metabolic Networks and Pathways; Methylamines; Middle Aged; Rifaximin	2020
Association of gut-related metabolites with outcome in acute heart failure. American heart journal, 2021, Volume: 234 Topics: Acetylcarnitine; Acute Disease; Aged; Aged, 80 and over; Betaine; Carnitine; Choline; Female; Gastrointestinal Microbiome; Heart Failure; Hospital Mortality; Humans; Male; Methylamines; Natriuretic Peptide, Brain; Risk Factors; Statistics, Nonparametric	2021
Using matrix-induced ion suppression combined with LC-MS/MS for quantification of trimethylamine-N-oxide, choline, carnitine and acetylcarnitine in dried blood spot samples. Analytica chimica acta, 2021, Mar-08, Volume: 1149 Topics: Acetylcarnitine; Carnitine; Choline; Chromatography, Liquid; Dried Blood Spot Testing; Humans; Methylamines; Oxides; Reproducibility of Results; Tandem Mass Spectrometry	2021
The use of an in-vitro batch fermentation (human colon) model for investigating mechanisms of TMA production from choline, L-carnitine and related precursors by the human gut microbiota. European journal of nutrition, 2021, Volume: 60, Issue:7 Topics: Animals; Carnitine; Choline; Colon; Fermentation; Gastrointestinal Microbiome; Humans; Methylamines	2021
Simultaneous quantification of trimethylamine N-oxide, trimethylamine, choline, betaine, creatinine, and propionyl-, acetyl-, and L-carnitine in clinical and food samples using HILIC-LC-MS. Analytical and bioanalytical chemistry, 2021, Volume: 413, Issue:21 Topics: Betaine; Carnitine; Choline; Chromatography, Liquid; Creatinine; Female; Food Analysis; Humans; Limit of Detection; Male; Methylamines; Middle Aged; Tandem Mass Spectrometry	2021
Elucidation of an anaerobic pathway for metabolism of l-carnitine-derived γ-butyrobetaine to trimethylamine in human gut bacteria. Proceedings of the National Academy of Sciences of the United States of America, 2021, 08-10, Volume: 118, Issue:32 Topics: Anaerobiosis; Betaine; Carbon; Carnitine; Clostridiales; Enzymes; Gastrointestinal Microbiome; Gene Expression Regulation, Bacterial; Humans; Methylamines; Microbiota; Multigene Family	2021
Resazurin-based high-throughput screening method for the discovery of dietary phytochemicals to target microbial transformation of L-carnitine into trimethylamine, a gut metabolite associated with cardiovascular disease. Food & function, 2022, May-23, Volume: 13, Issue:10 Topics: Cardiovascular Diseases; Carnitine; Gastrointestinal Microbiome; High-Throughput Screening Assays; Humans; Methylamines; Oxazines; Phytochemicals; Xanthenes	2022
Two-component carnitine monooxygenase from Escherichia coli: functional characterization, inhibition and mutagenesis of the molecular interface. Bioscience reports, 2022, 09-30, Volume: 42, Issue:9 Topics: Cardiovascular Diseases; Carnitine; Disulfides; Escherichia coli; Flavin Mononucleotide; Humans; Methylamines; Methylhydrazines; Mixed Function Oxygenases; Mutagenesis; Oxidoreductases; Oxygenases; Sulfinic Acids	2022
TMAO Upregulates Members of the miR-17/92 Cluster and Impacts Targets Associated with Atherosclerosis. International journal of molecular sciences, 2022, Oct-11, Volume: 23, Issue:20 Topics: Animals; Atherosclerosis; Betaine; Cardiovascular Diseases; Carnitine; Choline; Humans; Inflammation; Methylamines; Mice; MicroRNAs	2022
Quercetin inhibits hepatotoxic effects by reducing trimethylamine- Food & function, 2023, Jan-03, Volume: 14, Issue:1 Topics: Animals; Carnitine; Diet; Methylamines; Mice; Mice, Inbred C57BL; Oxides; Quercetin	2023
Neither Trimethylamine-N-Oxide nor Trimethyllysine Is Associated with Atherosclerosis: A Cross-Sectional Study in Older Japanese Adults. Nutrients, 2023, Feb-02, Volume: 15, Issue:3 Topics: Animals; Atherosclerosis; Carnitine; Carotid Intima-Media Thickness; Choline; Cross-Sectional Studies; East Asian People; Female; Humans; Methylamines; Oxides	2023
TRIMETHYLAMINE OXIDE - FACTOR IN THE DEVELOPMENT OF ATHEROSCLEROSIS AND A POTENTIAL TARGET FOR DIETARY AND PHARMACOLOGICAL INTERVENTIONS. Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego, 2023, Volume: 51, Issue:1 Topics: Atherosclerosis; Carnitine; Choline; Humans; Methylamines	2023