carnitine and simvastatin

carnitine has been researched along with simvastatin in 17 studies

Research

Studies (17)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (5.88)18.2507
2000's6 (35.29)29.6817
2010's6 (35.29)24.3611
2020's4 (23.53)2.80

Authors

AuthorsStudies
Artursson, P; Bergström, CA; Hoogstraate, J; Matsson, P; Norinder, U; Pedersen, JM1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A1
Artursson, P; Haglund, U; Karlgren, M; Kimoto, E; Lai, Y; Norinder, U; Vildhede, A; Wisniewski, JR1
Cantin, LD; Chen, H; Kenna, JG; Noeske, T; Stahl, S; Walker, CL; Warner, DJ1
Bellinghieri, G; Lamanna, F; Savica, V1
Hsieh, ST; Ishikawa, Y; Kim, JI; Miki, T; Tanaka, S; Taniguchi, T; Yasumoto, T; Yokoyama, M1
Arduini, A; Carminati, P; Giannessi, F; Peschechera, A1
Capurso, A; Capurso, C; Capurso, SA; Colacicco, AM; D'Introno, A; Fontana, C; Gadaleta, AM; Koverech, A; Panza, F; Solfrizzi, V; Torres, F1
Galvano, F; Li Volti, G; Malaguarnera, M; Motta, M; Vacante, M1
Antic, T; Avitabile, T; Galvano, F; Li Volti, G; Malaguarnera, M; Vacante, M1
Costa, RA; de Souza-Pinto, NC; Fernandes, MP; Vercesi, AE1
Bilianou, E; Elisaf, MS; Florentin, M; Liberopoulos, EN; Nikolaou, V; Pitsavos, C; Rizos, CV1
El-Adeeb, N; Elmasry, A; Ghalwash, M1
Antunes, NJ; Campos, R; De Nucci, G; Dezena, RMB; Ilha, J; Mendes, GD; Moreno, RA; Rosa, PCP1
Badreldeen, A; El Amrousy, D; El Razaky, O; El-Bendary, A; Erfan, A1
Abraldes, JG; Alessandria, C; Beuers, U; Campion, D; Caraceni, P; Carol, M; Davis, MM; de Wit, K; Durand, F; Francoz, C; Ginès, P; Jiménez, C; Juanola, A; Kamath, PS; Kazankov, K; Lozano, JJ; Ma, AT; Mookerjee, RP; Morales-Ruiz, M; Napoleone, L; Piano, S; Pose, E; Sidorova, J; Solà, E; Tonon, M; Trebicka, J; Uschner, F; Vargas, V; Watson, H; Zaccherini, G1
Abd El Reheem, MH; Ahmed, SA; Elbahy, DA1

Trials

6 trial(s) available for carnitine and simvastatin

ArticleYear
Efficacy and tolerability of combined treatment with L-carnitine and simvastatin in lowering lipoprotein(a) serum levels in patients with type 2 diabetes mellitus.
    Atherosclerosis, 2006, Volume: 188, Issue:2

    Topics: Aged; Apolipoproteins B; Carnitine; Cholesterol; Diabetes Mellitus, Type 2; Drug Therapy, Combination; Female; Humans; Hyperlipoproteinemias; Hypolipidemic Agents; Italy; Lipoprotein(a); Male; Middle Aged; Simvastatin; Triglycerides

2006
Effect of L-carnitine on the size of low-density lipoprotein particles in type 2 diabetes mellitus patients treated with simvastatin.
    Metabolism: clinical and experimental, 2009, Volume: 58, Issue:11

    Topics: Adult; Aged; Blood Glucose; Carnitine; Diabetes Mellitus, Type 2; Female; Glycated Hemoglobin; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lipids; Lipoproteins, LDL; Male; Middle Aged; Particle Size; Simvastatin

2009
Effects of simvastatin and carnitine versus simvastatin on lipoprotein(a) and apoprotein(a) in type 2 diabetes mellitus.
    Expert opinion on pharmacotherapy, 2009, Volume: 10, Issue:12

    Topics: Apoprotein(a); Blood Glucose; Body Mass Index; Carnitine; Cholesterol, HDL; Cholesterol, LDL; Diabetes Mellitus, Type 2; Double-Blind Method; Drug Therapy, Combination; Dyslipidemias; Female; Glycated Hemoglobin; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypolipidemic Agents; Lipoprotein(a); Male; Middle Aged; Simvastatin; Triglycerides

2009
L-Carnitine/Simvastatin Reduces Lipoprotein (a) Levels Compared with Simvastatin Monotherapy: A Randomized Double-Blind Placebo-Controlled Study.
    Lipids, 2017, Volume: 52, Issue:1

    Topics: Adult; Apolipoprotein B-100; Cardiovascular Diseases; Carnitine; Cholesterol; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Hyperlipoproteinemia Type V; Lipoprotein(a); Male; Middle Aged; Prospective Studies; Simvastatin; Treatment Outcome; Triglycerides; Young Adult

2017
Comparative study of the efficacy of captopril, simvastatin, and L-carnitine as cardioprotective drugs in children with type 1 diabetes mellitus: a randomised controlled trial.
    Cardiology in the young, 2021, Volume: 31, Issue:8

    Topics: Captopril; Carnitine; Carotid Intima-Media Thickness; Child; Diabetes Mellitus, Type 1; Humans; Pharmaceutical Preparations; Simvastatin

2021
Treatment With Simvastatin and Rifaximin Restores the Plasma Metabolomic Profile in Patients With Decompensated Cirrhosis.
    Hepatology communications, 2022, Volume: 6, Issue:5

    Topics: Acute-On-Chronic Liver Failure; Carnitine; Humans; Kynurenine; Liver Cirrhosis; Metabolomics; Rifaximin; Simvastatin; Tryptophan

2022

Other Studies

11 other study(ies) available for carnitine and simvastatin

ArticleYear
Prediction and identification of drug interactions with the human ATP-binding cassette transporter multidrug-resistance associated protein 2 (MRP2; ABCC2).
    Journal of medicinal chemistry, 2008, Jun-12, Volume: 51, Issue:11

    Topics: Administration, Oral; Animals; Antineoplastic Agents; Antipsychotic Agents; Antiviral Agents; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Biological Transport; Cell Line; Computer Simulation; Cytochrome P-450 Enzyme System; Drug-Related Side Effects and Adverse Reactions; Estradiol; Humans; Insecta; Liver; Models, Molecular; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Neoplasm Proteins; Pharmaceutical Preparations; Pharmacology; Structure-Activity Relationship

2008
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
    Chemical research in toxicology, 2010, Volume: 23, Issue:1

    Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship

2010
Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions.
    Journal of medicinal chemistry, 2012, May-24, Volume: 55, Issue:10

    Topics: Atorvastatin; Biological Transport; Drug Interactions; Estradiol; Estrone; HEK293 Cells; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Least-Squares Analysis; Liver; Liver-Specific Organic Anion Transporter 1; Models, Molecular; Multivariate Analysis; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Protein Isoforms; Pyrroles; Solute Carrier Organic Anion Transporter Family Member 1B3; Structure-Activity Relationship; Transfection

2012
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification.
    Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:12

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Humans; Quantitative Structure-Activity Relationship

2012
[The hypotriglyceridemic action of the combination of L-carnitine + simvastatin vs. L-carnitine and vs. simvastatin].
    La Clinica terapeutica, 1992, Volume: 140, Issue:1 Pt 2

    Topics: Aged; Anticholesteremic Agents; Carnitine; Combined Modality Therapy; Drug Evaluation; Drug Therapy, Combination; Female; Humans; Hypertriglyceridemia; Kidney Failure, Chronic; Lovastatin; Male; Middle Aged; Renal Dialysis; Simvastatin

1992
A case of severe hyperlipidemia caused by long-term tube feedings.
    Journal of atherosclerosis and thrombosis, 2003, Volume: 10, Issue:5

    Topics: Aged; Carnitine; Dietary Sucrose; Enteral Nutrition; Female; Food, Formulated; Humans; Hyperlipidemias; Hypolipidemic Agents; Rhabdomyolysis; Simvastatin

2003
Improvement of statin-associated myotoxicity by L-carnitine.
    Journal of thrombosis and haemostasis : JTH, 2004, Volume: 2, Issue:12

    Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Carnitine; Cell Membrane; Cholesterol; Creatine Kinase; Drug Synergism; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Muscles; Rats; Rats, Wistar; Simvastatin

2004
Protective effects of l-carnitine and piracetam against mitochondrial permeability transition and PC3 cell necrosis induced by simvastatin.
    European journal of pharmacology, 2013, Feb-15, Volume: 701, Issue:1-3

    Topics: Carnitine; Cell Line, Tumor; Cyclosporine; Drug Synergism; Humans; Mitochondria; Mitochondrial Membrane Transport Proteins; Mitochondrial Permeability Transition Pore; Necrosis; Piracetam; Simvastatin; Superoxides

2013
Effect of L-carnitine on the skeletal muscle contractility in simvastatin-induced myopathy in rats.
    Journal of basic and clinical physiology and pharmacology, 2018, 09-25, Volume: 29, Issue:5

    Topics: Animals; Carnitine; Cholesterol; Female; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Muscle Contraction; Muscle, Skeletal; Muscular Diseases; Oxidative Stress; Rats; Rats, Wistar; Simvastatin

2018
Pharmacodynamic evaluation of L-carnitine and piracetam in muscle injury induced by the chronic use of simvastatin.
    International journal of clinical pharmacology and therapeutics, 2020, Volume: 58, Issue:9

    Topics: Alanine Transaminase; Aspartate Aminotransferases; Carnitine; Humans; Male; Piracetam; Simvastatin

2020
l-Carnitine ameliorates the osteoporotic changes and protects against simvastatin induced myotoxicity and hepatotoxicity in glucocorticoid-induced osteoporosis in rats.
    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2022, Volume: 152

    Topics: Animals; Carnitine; Chemical and Drug Induced Liver Injury; Glucocorticoids; Myotoxicity; Osteoporosis; Rats; Rats, Wistar; Simvastatin

2022