carnitine has been researched along with s-adenosylmethionine in 1098 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 6 (0.55) | 18.7374 |
| 1990's | 35 (3.19) | 18.2507 |
| 2000's | 248 (22.59) | 29.6817 |
| 2010's | 593 (54.01) | 24.3611 |
| 2020's | 216 (19.67) | 2.80 |
| Authors | Studies |
|---|---|
| Jakobs, C; Roe, CR; ten Brink, HJ; Verhoeven, NM; Wanders, RJ | 1 |
| Evengard, B; Kanakura, Y; Kawata, S; Kitani, T; Kuratsune, H; Långström, B; Lindh, G; Machii, T; Matsumura, K; Takahashi, M; Takaishi, J; Watanabe, Y; Yamaguti, K | 1 |
| Becker, LE; Bennett, MJ; Haslam, RH; Rhead, WJ; Tein, I; Vockley, J | 1 |
| Harashima, H; Hayashi, M; Horiuchi, M; Kamido, H; Kudo, T; Kuwajima, M; Lu, K; Ono, A; Ozaki, K; Saheki, T; Sei, M; Shima, K | 1 |
| Brühlmann, P; Hoppeler, H; Krähenbühl, S; Stucki, G; Willer, B | 1 |
| de Hoffmann, E; Libert, R; Nassogne, MC; Schanck, A; Stroobant, V; Thillaye, M; Van Hoof, F; Vincent, MF | 1 |
| Bonham, JR; Downing, M; Edwards, RG; Manning, NJ; Olpin, SE; Pollitt, RJ; Pourfarzam, M; Sharrard, MJ; Tanner, MS | 1 |
| Matsumoto, Y | 1 |
| Bayés, R; Campoy, C; López, C; Molina-Font, JA; Peinado, JM; Rivero, M | 1 |
| Allers, P; Costa, CG; Duran, M; Ijlst, L; Jakobs, C; Ruiter, J; Struys, EA; Tavares de Almeida, I; Ventura, FV; Wanders, RJ | 1 |
| Alhomida, AS | 1 |
| al Aqeel, AI; Rashed, MS; Wanders, RJ | 1 |
| Bootsma, AH; Overmars, H; van Gennip, AH; van Lint, AE; Vreken, P; Wanders, RJ | 2 |
| Hillman, SL; Matern, D; Mayatepek, E; Millington, DS; Strauss, AW; Trefz, FK | 1 |
| Gibson, B; Hahn, SH; Hong, CH; Jung, JW; Lee, EH; Rinaldo, P; Sims, H; Strauss, AW; Yoon, HR | 1 |
| Haseler, LJ; Karpinski, NC; Terkeltaub, RA; Videen, JS | 1 |
| Carregal, M; Cerruti, S; Dalamon, V; Savino, EA; Testoni, G; Varela, A | 1 |
| Carter, AL; Ganapathy, ME; Ganapathy, V; Hopfer, U; Huang, W; Leibach, FH; Shaikh, SN | 1 |
| Adachi, Y; Azuma, A; Hirasaki, S; Ito, K; Kinoshita, N; Kodo, N; Matsuo, A; Nakagawa, M; Nakamura, T; Sugihara, H | 1 |
| Inoue, F; Kinugasa, A; Kizaki, Z; Kodo, N; Nakajima, H; Okochi, M; Sawada, T; Terada, N | 1 |
| Bryant, SD; Doncel, GF; Gandour, RD; Hubieki, MP; Robinette, RG; Savle, PS | 1 |
| Costa, CC; de Almeida, IT; Duran, M; Jakobs, C; Poll-The, BT | 1 |
| Aleck, K; Ding, JH; Grebe, TA; He, G; Roe, CR; Roe, DS; Teramoto, R; Yang, BZ | 1 |
| Carotti, A; Cellamare, S; D'Acquarica, I; Gasparrini, F; Misiti, D; Muck, S; Villani, C | 1 |
| Bonnet, D; Brivet, M; Jouvet, P; Martin, D; Rabier, D; Saudubray, JM; Villain, E | 1 |
| Jackson, JM | 1 |
| Chace, DH; Naylor, EW | 1 |
| Iacobazzi, V; Lasorsa, FM; Palmieri, F; Palmieri, L; Runswick, MJ; Walker, JE | 1 |
| Carpenter, K; Wilcken, B; Wiley, V | 1 |
| Georgala, C; Georgala, S; Michas, T; Schulpis, KH | 1 |
| Brivet, M; Roe, CR; Roe, DS; Sweetman, L | 1 |
| Heinig, K; Henion, J | 1 |
| Bennett, MJ; Chen, YT; Feezor, MD; Hillman, S; Kahler, SG; Matern, D; Millington, DS; Qumsiyeh, M; Shen, JJ; Van Hove, JL | 1 |
| Bartlett, K; Eaton, S; Markley, MA; New, KJ; Pourfarzam, M; Quant, PA | 1 |
| Abdenur, JE; Bernard, CI; Chamoles, NA; Guinle, A; Jorge, L; Lavorgna, S; Levandowskiy, V; Schenone, AB; Specola, N | 1 |
| Cyr, D; Giguère, R; Giguère, Y; Lemieux, B | 1 |
| de Hoffmann, E; Libert, R; Nassogne, MC; Schanck, A; Thillaye, M; Van Hoof, F; Vincent, MF | 1 |
| al-Essa, MA; Bakheet, SM; Ozand, PT; Patay, ZJ; Rashed, MS | 1 |
| Andresen, BS; Korall, H; Schwahn, B; Spiekerkötter, U; Trefz, FK; Wendel, U | 1 |
| Burlingame, TG; Gibson, KM; Hogema, B; Jakobs, C; Kiss, D; Linck, L; Millington, D; Pohowalla, P; Rinaldo, P; Roe, CR; Roe, DS; Sacks, M; Schutgens, RB; Steiner, RD; Sweetman, L; Vockley, J | 1 |
| Debreceni, B; Farkas, V; Fischer, GM; Laszlo, A; Nemeti, B; Sandor, A; Schaffer, Z; Somogyi, C | 1 |
| Bleijenberg, G; Elving, LD; Janssen, AJ; Soetekouw, PM; van der Meer, JW; van der Veen, Y; Vreken, P; Wevers, RA | 1 |
| Dorland, L; Duran, M; IJlst, L; Muntau, AC; Roscher, AA; Röschinger, W; Wanders, RJ | 1 |
| Arnecke, R; Balling, R; Dame, T; Hrabé de Angelis, M; Kreischer, J; Olgemöller, B; Rolinski, B; Roscher, AA; Wolf, E | 1 |
| Kanter, EM; Newatia, A; Yamada, KA | 1 |
| Deutsch, J; Kalderon, B; Purdon, AD; Rapoport, SI | 1 |
| Brass, EP | 1 |
| Baillet, L; Esser, V; McGarry, JD; Mullur, RS | 1 |
| Han, IK; Heo, K; Lin, X; Odle, J | 1 |
| Feezor, MD; Hart, P; Kahler, SG; Matern, D; Millington, DS; Ramakrishna, JP; Shen, JJ; Treem, WR; Van Hove, JL | 1 |
| Arenas, J; Börnstein, B; Campos, Y; de la Calzada, CS; Gómez, MA; Guillén, F; Martín, MA; Rubio, JC | 1 |
| Krähenbühl, S; Thormann, W; Vernez, L | 1 |
| Kohlmueller, D; Linderkamp, O; Mayatepek, E; Meyburg, J; Schulze, A | 1 |
| Blakely, JA; Johnson, MD; Stewart, JM | 1 |
| Kuratsune, H | 1 |
| Carpenter, K; Sim, KG; Wilcken, B; Wiley, V | 2 |
| Adler, S; Amato, A; Brass, EP; Hiatt, WR; Orlando, AM; Sietsema, KE | 1 |
| Haro, D; Hegardt, FG; Marrero, PF; Nicot, C; Woldegiorgis, G | 1 |
| Andresen, BS; Banas, R; Bross, P; Chace, DH; Dobrowolski, SF; Engel, P; Frazier, DM; Gregersen, N; Knudsen, I; McCandless, SE; Muenzer, J; Naylor, EW; O'Reilly, L; Udvari, S | 1 |
| Le, W; Liang, X; Schulz, H; Zhang, D | 1 |
| Brandt, NJ; Christensen, E; Jensen, UG; Nørgaard-Pedersen, B; Simonsen, H; Skovby, F | 1 |
| Fiesel, S; Hoffmann, GF; Lindner, M; Mayatepek, E; Olgemöller, K; Penzien, J; Ruiter, JP; Schulze, A; Wanders, RJ; Zschocke, J | 1 |
| Abdenur, JE; Bernard, C; Chamoles, NA; Fusta, M; Guinle, A; Jorge, L; Lavorgna, S; Levandovskiy, V; Schenone, AB | 1 |
| Chace, DH; DiPerna, JC; Hofman, LF; Mitchell, BL; Naylor, EW; Sgroi, B | 1 |
| Bakr, S; Bergmann, SR; Hwang, Y; Ramasamy, R | 1 |
| Aynsley-Green, A; Berger, R; Clayton, PT; Datta, V; Eaton, S; Edginton, M; Hussain, K; Krywawych, S; Malingre, HE; van den Berg, IE | 1 |
| Amoroso, A; Boniotto, M; Braida, L; Casetta, B; Crovella, S; de Vonderweid, U; Luchesi, A | 1 |
| de Almeida, IT; Duran, M; Jakobs, C; Silva, MF; Wanders, RJ | 1 |
| Carpenter, K; Heath, D; Sim, KG; Wilcken, B; Wiley, V | 1 |
| Arnecke, R; Dame, T; Fingerhut, R; Kreischer, J; Liebl, B; Muntau, AC; Olgemöller, B; Roscher, AA; Röschinger, W; Superti-Furga, A; Troxler, H | 1 |
| Roe, CR; Roe, DS; Sharma, S; Vianey-Saban, C; Zabot, MT | 1 |
| Cox, KB; Hamm, DA; Lindsey, JR; Matern, D; Millington, DS; Pinkert, CA; Rhead, WJ; Rinaldo, P; Vockley, J; Wood, PA | 1 |
| Kamimori, H; Konishi, M | 1 |
| Chisholm, CA; Frerman, FE; Lovell, MA; Roe, CR; Roe, DS; Sweetman, L; Vavelidis, F; Wilson, WG | 1 |
| Baena, RM; Bayés, R; Campoy, C; Goicoechea, A; López, C; Molina-Font, JA; Pedrosa, T; Peinado, JM; Rivero, M | 1 |
| Hatsutanmaru, K; Masuda, A; Nakayama, T; Tei, C; Yamanaka, T | 1 |
| de Almeida, IT; Duran, M; Maya, M; Overmars, H; Selhorst, J; Silva, MF; van Gennip, AH; Wanders, RJ | 1 |
| Carpenter, K; Christodoulou, J; Hammond, J; Sim, KG; Wilcken, B | 1 |
| Angsten, G; Boberg, M; Cederblad, G; Meurling, S; Stiernström, H | 1 |
| Bauer, MF; Bieger, I; Gempel, K; Gerbitz, KD; Hofmann, S; Kiechl, S; Kiechl-Kohlendorfer, U; Lochmüller, H; Pongratz, D; Rettinger, A; Sperl, W; Willeit, J | 1 |
| Kimura, M; Yamaguchi, S | 1 |
| Green, A; Hardy, D; Preece, MA | 1 |
| Hansen, EA; Johnson, GS; Katz, ML; Sanders, DA; Sanders, DN | 1 |
| Kushnir, MM; Pasquali, M; Roberts, WL; Shushan, B | 1 |
| Can, S; Coker, C; Coker, M; Darcan, S; Gökşen, D; Orbak, Z | 1 |
| Carpenter, KH; Wiley, V | 1 |
| Carpenter, K; Christodoulou, J; Giak Sim, K; Hammond, J; Wilcken, B | 1 |
| Duclos, RI; Hamilton, JA; Ho, JK | 1 |
| Hoffmann, GF; Kohlmüller, D; Kölker, S; Lindner, M; Mayatepek, E; Okun, JG; Olgemöller, K; Schulze, A; Wanders, RJ | 1 |
| Champion, MP; Dalton, RN; Turner, C; Wraige, E | 1 |
| Eggington, M; Kahler, SG; Pitt, JJ | 1 |
| Al-Hussein, K; Bucknall, MP; Rahbeeni, Z; Rashed, MS; Ruiter, J; Vaz, FM; Wanders, RJ | 1 |
| Hoffmann, GF; Kohlmueller, D; Linderkamp, O; Mayatepek, E; Meyburg, J; Pöschl, J; Schulze, A | 1 |
| Cerruti, S; Dalamon, V; Kade, P; Savino, EA; Testoni, G; Varela, A | 1 |
| Bakr, S; Bergmann, SR; Hwang, YC; Ramasamy, R | 1 |
| Buehrdel, P; Ceglarek, U; Ethofer, T; Mueller, P; Schindler, I; Schulze, A | 1 |
| Armstrong, DL; Scaglia, F; Scheuerle, AE; Sweetman, L; Towbin, JA; Wong, LJ | 1 |
| Brüggemann, L; Kiessling, A; Löster, H; Möder, M | 1 |
| Hopfgartner, G; Krähenbühl, S; Vernez, L; Wenk, M | 1 |
| Boenzi, S; Caruso, U; Dionisi-Vici, C; Duran, M; Rizzo, C; Wanders, RJ | 1 |
| Bailey, KS; Kruckeberg, KE; Matern, D; Nagan, N; Rinaldo, P; Tauscher, AL | 1 |
| Hoffmann, GF; Kohlmüller, D; Lindner, M; Mayatepek, E; Olgemöller, K; Schulze, A | 1 |
| Burlingame, T; Connor, WE; Gillingham, MB; Harding, CO; Matern, D; Meeuws, K; Rinaldo, P | 1 |
| Hata, I; Kimura, M; Sakaguchi, M; Shigematsu, Y; Tokunaga, Y; Watanabe, Y; Yamaguchi, S; Yoshida, I; Yoshino, M | 1 |
| Andresen, BS; Berry, SA; He, M; Lussky, RC; Madsen, PP; Matern, D; Rinaldo, P; van Calcar, SC; Vockley, J; Whitley, CB; Wolff, JA | 1 |
| Cordeau, S; Gavino, G; Gavino, VC | 1 |
| Boney, A; Chaing, S; Frazier, DM; Kishnani, PS; Koeberl, DD; McCandless, SE; McDonald, MT; Millington, DS; Moore, E; Muenzer, J; Smith, WE; Weavil, SD | 1 |
| Aburatani, H; Fukada, S; Ikeda, K; Matsuura, A; Nimura, Y; Sato, N; Sekoguchi, E; Yasui, A | 1 |
| Bollaert, PE; de Chillou, C; Feillet, F; Lefebvre, E; Sadoul, N; Steinmann, G; Vianey-Saban, C; Vidailhet, M | 1 |
| Dixon, MA; Leonard, JV; Lund, AM; Morris, AA; Vreken, P | 1 |
| Chang, YS; Hwang, SJ; Jin, DK; Lee, JE; Paik, KH; Park, WS; Shim, JW; Strauss, AW; Yoon, HR | 1 |
| FRITZ, IB; YUE, KT | 1 |
| BRESSLER, R; FRIEDBERG, SJ | 1 |
| BRESSLER, R; WITTELS, B | 1 |
| Arenas, J; Castellano, G; Colina, F; Del Hoyo, P; Martín, A; Martín, MA; Pérez-Carreras, M; Rubio, JC; Solis-Herruzo, JA | 1 |
| Fukao, T; Hazama, A; Kohno, Y; Kondo, M; Kondo, N; Kubo, T; Matsuo, N; Sakura, N; Shigematsu, Y; Yamaga, H; Yamaguchi, S; Zhang, GX | 1 |
| Fowler, KJ; Gazeas, S; Ioannou, PA; Kahler, SG; Nefedov, M; Peters, H; Pitt, J; Sarsero, J | 1 |
| Bali, D; Gregersen, N; Koeberl, DD; Liu, HM; Matern, D; Millington, DS; Stevens, RD; Young, SP | 1 |
| Chace, DH; Kalas, TA; Naylor, EW | 1 |
| Bain, MD; Baric, I; Chalmers, RA; Feyh, P; Hoffmann, GF; Jakobs, C; Jeffrey, I; Kölker, S; Okun, JG; Pourfarzam, M; Schor, DS; Wagner, L; Zschocke, J | 1 |
| Donati, MA; la Marca, G; Malvagia, S; Morrone, A; Pasquini, E; Zammarchi, E | 1 |
| Arduini, A; Sweeney, JD | 1 |
| Bocian, M; Boyle, K; Gargus, JJ; Roe, CR; Roe, DS; Vianey-Saban, C | 1 |
| Davis, AT; Spry, L; Steiber, AL; Weatherspoon, LJ | 1 |
| An, J; Cline, GW; Fujimoto, Y; Koves, TR; Millington, D; Muoio, DM; Newgard, CB; Shiota, M; Shulman, GI; Stevens, R | 1 |
| Lehotay, DC; LePage, J; Rockman-Greenberg, C; Thompson, JR | 1 |
| Duran, M; Exil, V; Mayatepek, E; Spiekerkoetter, U; Strauss, AW; Tokunaga, C; Wanders, RJ; Wendel, U; Wijburg, FA | 1 |
| Johnson, DW | 1 |
| Birk, OS; Galron, D; Hershkovitz, E; Kazanovitz, A; Moses, SW | 1 |
| Krähenbühl, S; Vernez, L; Wenk, M | 1 |
| Andresen, BS; Brooks, R; Gregersen, N; Gutman, A; Korman, SH; Sinnathamby, T | 1 |
| Napolitano, N; Pitt, JJ; Wiley, V | 1 |
| Lai, CC; Lee, CC; Lin, WD; Tsai, FJ; Wang, CH | 1 |
| Azuero, R; Debata, C; McDonough, K; Penn, D; Quinn, M; Thomson, J | 1 |
| Sander, S; Sass, JO; Zschocke, J | 1 |
| Hiatt, WR | 1 |
| Aubey, F; Bastin, J; Djouadi, F; Schlemmer, D | 1 |
| Hoppel, CL; Kerner, J; Minkler, PE; North, KN | 1 |
| Durka, S; Heizmann, CW; Kleinert, P; Kuster, T; Neuheiser, F; Torresani, T; Troxler, H | 1 |
| Bourdoux, P; Cavedon, CT; de Laet, C; Goyens, P; Herremans, N; Mertens, K; Van Thi, HV | 1 |
| Liapi-Adamidou, G; Tsagris, V | 1 |
| Hoppel, CL; Ingalls, ST; Minkler, PE | 1 |
| Duran, M; Ijlst, L; Mayatepek, E; Overmars, H; Spiekerkoetter, U; Strauss, AW; Tokunaga, C; van Vlies, N; Vaz, FM; Wanders, RJ; Wendel, U; Wijburg, FA | 1 |
| Bucuvalas, J; Emre, S; Gondolesi, G; Hynan, LS; Magid, M; Morotti, R; Narkewicz, M; Rinaldo, P; Shneider, BL; Squires, R | 1 |
| Abendschein, DR; Gross, RW; Han, X; Mancuso, DJ; Su, X | 1 |
| Bodamer, OA; Holub, M; Item, C; Mühl, A; Pollak, A; Stöckler-Ipsiroglu, S | 1 |
| Chalmers, RA; Harrison, EL; Jones, MG; Jones, S; Lee, PJ; Leonard, JV | 1 |
| Cline, GW; Coleman, RA; Hammond, LE; Ilkayeva, OR; Muoio, DM; Neschen, S; Romanelli, AJ; Shulman, GI | 1 |
| Czech, E; Nowicka, J; Olszowy, Z | 1 |
| Matern, D; Schowalter, DB; Vockley, J | 1 |
| Andresen, BS; Bischoff, C; Bonham, JR; Chakrapani, A; Clark, S; Downing, M; Gregersen, N; Manning, NJ; Muntoni, F; Olpin, SE; Olsen, RK; Pourfarzam, M; Sharrard, M; Turnbull, DN | 1 |
| Browning, MF; Larson, C; Marsden, DL; Strauss, A | 1 |
| Blois, B; Dooley, K; Dyack, S; Riddell, C | 1 |
| House, R; Lin, X; Odle, J | 1 |
| Amjad, S; Chalmers, RA; Goodwin, CS; Jones, MG | 1 |
| Cha, YS; Cho, SW | 1 |
| Macey, H; Moreno, FA; Schreiber, B | 1 |
| Eyer, F; Felgenhauer, N; Gempel, K; Gerbitz, KD; Steimer, W; Zilker, T | 1 |
| Ghoshal, AK; Guo, T; Soldin, SJ; Soukhova, N | 1 |
| Aubey, F; Bastin, J; Djouadi, F; Ruiter, JP; Schlemmer, D; Strauss, AW; Wanders, RJ | 1 |
| Gutman, A; Jakobs, C; Korman, SH; Wanders, RJ; Waterham, HR | 1 |
| Chace, DH; Evans, AM; Faull, RJ; Fornasini, G; Reuter, SE | 1 |
| Greenberg, CR; Haas, D; Hoffmann, GF; Kohlmüller, D; Kölker, S; Lindner, M; Mayatepek, E; Okun, JG; Schulze-Bergkamen, A; Schulze-Bergkamen, H; Spiekerkötter, U; Zschocke, J | 1 |
| Liu, A; Pasquali, M | 1 |
| Balay, J; Ghoshal, AK; Soldin, SJ | 1 |
| Dickenmann, M; Krähenbühl, S; Steiger, J; Vernez, L; Wenk, M | 1 |
| Andresen, BS; Angel, L; Bennetts, B; Carpenter, K; Waddell, L; Wilcken, B; Wiley, V | 1 |
| Roe, CR; Roe, DS; Struys, E; Sweetman, L; Vianey-Saban, C; Yang, BZ | 1 |
| Adamovich, K; Arnecke, R; Decsi, T; Demmelmair, H; Koletzko, B; Lehner, F; Röschinger, W; Szász, M | 1 |
| Bøersheim, E; Cree, MG; Sun, D; Wolfe, RR; Zhang, XJ | 1 |
| Chace, DH; Kohli, R; Wainwright, MS; Whitington, PF | 1 |
| Bennett, MJ; Fuda, F; Narayan, SB; Squires, RH | 1 |
| de Sain, MG; Dorland, L; Engbers, HM; Eskes, PF; Visser, G | 1 |
| Bodamer, OA; Hussein, K; Langhans, CD; Leonard, JV; Mayatepek, E; Morris, AA; Rating, D | 1 |
| Böhm, M; Chrastina, R; Hansíková, H; Honzík, T; Martincová, O; Plavka, R; Zapadlo, M; Zeman, J | 1 |
| Campbell, CD; Ficicioglu, C; Ganesh, J | 1 |
| Beresford, MW; Davidson, JE; Pourfarzam, M; Turnbull, DM | 1 |
| Inazu, M; Maehara, K; Matsumiya, T; Miyashita, K; Takeda, H; Tomoda, A | 1 |
| Fouque, D; Guebre-Egziabher, F; Hadj-Aïssa, A; Holt, S; Hoppel, CL; Kopple, JD; Nakamura, K; Vianey-Saban, C | 1 |
| Crnic, LR; Fricker, G; Goodman, SI; Harding, CO; Hoffmann, GF; Hörster, F; Koeller, DM; Kölker, S; Mahringer, A; Mühlhausen, C; Müller, I; Okun, JG; Sauer, SW | 1 |
| Aledo, R; Casals, N; Champion, MP; Dalton, RN; Hegardt, FG; Mir, C; Pié, J; Turner, C | 1 |
| Mattevi, A | 1 |
| Chang, MH; Chen, HL; Chien, YH; Chiu, PC; Hwu, WL; Kobayashi, K; Lee, NC; Ni, YH; Saheki, T | 1 |
| Bodamer, OA; Heinze, G; Holub, M; Mühl, A; Ratschmann, R; Sperl, W; Strnadová, KA; Tuschl, K | 1 |
| Chan, CT; Fisher, L; Geary, DF; Hothi, DK | 1 |
| Liebig, M; Mayatepek, E; Mueller, M; Schymik, I; Spiekerkoetter, U; Strauss, AW; Wanders, RJ; Wendel, U | 1 |
| Calvani, M; Duran, M; Iannoni, E; Mancinelli, A | 1 |
| Clark, S; Day, C; Henderson, MJ; Olpin, S; Patterson, A; Savill, G; Vijay, S; Walter, JH | 1 |
| Hoppel, C; Minkler, P; Tserng, KY; Yang, S | 1 |
| Duran, M; Huidekoper, HH; Schneider, J; Vaz, FM; Westphal, T; Wijburg, FA | 1 |
| Azocar, M; Cano, F; Guerrero, JL; Marín, VB; Molina, M; Ratner, R | 1 |
| Aguilar-Kitsu, A; Castillo-Romero, L; Ibarra-Cazares, P; Mendoza-Guevara, L; Morales-Nava, A; Perez Andrade, ME; Rodriguez-Leyva, F; Sanchez-Barbosa, L; Villasis-Keever, MA | 1 |
| Anderson, BD; Freedenberg, D; Hahn, SH; Kramer, KA; Oglesbee, D | 1 |
| Kamlekar, RK; Swamy, MJ | 1 |
| Blobel, H; Gottschalk, J; Hoffmann, GF; Kölker, S; Köppel, S; Waterham, HR | 1 |
| Chien, YH; Chu, KL; Huang, HP; Hwu, WL; Wang, SF; Wei, ML; Wu, ST | 1 |
| Chen, YH; Chen, YT; Cheng, CF; Huang, CC; Hung, SI; Kao, HJ; Kikuchi, T; Millington, D; Wu, JY | 1 |
| Choi, JH; Kim, GH; Park, SJ; Shin, YL; Yoo, HW; Yoon, HR | 1 |
| Gerstner, T; Koenig, SA; Kohlmueller, D; Longin, E; Mehlem, P; Schulze, A; Teich, M; Treiss, I; Werner, T | 1 |
| Bodamer, OA; Heinze, G; Holub, M; Lebl, J; Mascher, H; Mühl, A; Ratschmann, R; Stöckler-Ipsiroglu, S; Strnadová, KA; Votava, F; Waldhauser, F | 1 |
| Ito, T; Kurono, Y; Maeda, Y; Sugiyama, N; Sumi, S; Suzuki, A; Togari, H; Ueta, A; Yokoi, K | 1 |
| Endo, M; Hasegawa, Y; Kobayashi, H; Purevsuren, J; Yamaguchi, S | 1 |
| Ahmad, A; Angle, B; Burton, B; Charrow, J; Ensenauer, R; Ficicioglu, CH; Hahn, SH; He, M; Keppen, LD; Majumder, N; Marsden, D; Matern, D; Oglesbee, D; Tortorelli, S; Vockley, J | 1 |
| Dubois, J; Hulver, MW; Ilkayeva, O; Marchand, RM; Muoio, DM; Mynatt, RL; Power, RA; Zhang, JY | 1 |
| Durkin, MS; Gleason, LA; Hoffman, G; Lindh, H; Rhead, W; van Calcar, SC; Vockley, G; Wolff, JA | 1 |
| Ahn, EM; Cha, YS; Cho, SC; Lee, M | 1 |
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| Fehrenbach, E; Fritsche, J; Häring, HU; Hoene, M; Lehmann, R; Machann, J; Niess, AM; Schick, F; Schleicher, ED; Simon, P; Wang, J; Weigert, C; Xu, G; Zhao, X | 1 |
| Baumgartner, MR; De Jesus Silva Arevalo, G; Figueroa, AW; Fingerhut, R; Fresse, EM; Häberle, J; Polanco, OL; Rohrbach, M; Torresani, T | 1 |
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| Bain, JR; Huffman, KM; Kraus, VB; Kraus, WE; Landerman, LR; Muehlbauer, MJ; Newgard, CB; Pieper, CF; Ravussin, E; Redman, LM; Stevens, RD; Wenner, BR | 2 |
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| Chan, AO; Chan, AY; Chen, SP; Ching, CK; Lai, CK; Lam, CW; Law, CY; Lee, HC; Mak, CM; Shek, CC; Siu, TS; Siu, WK; Tai, HL; Tam, S; Yuen, YP | 1 |
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| Carlier, C; Demmelmair, H; Escribano, J; Ferre, N; Grote, V; Gruszfeld, D; Harder, U; Hellmuth, C; Kirchberg, FF; Koletzko, B; Peissner, W; Rzehak, P; Socha, P; Verduci, E; Weber, M; Xhonneux, A | 1 |
| Chow, HH; Hu, C; Keun, HC; Lang, JE; Miller, JA; Pappan, K; Siskos, AP; Thompson, PA; Want, EJ; Wulff, J | 1 |
| Hagar, A; Hall, PL; Wittenauer, A | 1 |
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| Colucci, WS; Elezaby, A; Liesa, M; Luptak, I; Miller, EJ; Qin, F; Rimer, J; Schaffer, JE; Shirihai, OS; Soni, K; Sverdlov, AL; Tu, VH | 1 |
| Ciapaite, J; Houten, SM; Jeneson, JA; Nicolay, K; van den Berg, SA; van Dijk, KW | 1 |
| Bogusiewicz, A; Boysen, G; Mock, DM | 1 |
| Abe, M; Ando, H; Higuchi, T; Kikuchi, F; Mizuno, M; Oikawa, O; Okada, K; Okawa, E; Soma, M; Yamazaki, T | 1 |
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| Boneh, A; Morrisy, S; Pitt, J; Tal, G; Tzanakos, N | 1 |
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| Akaza, K; Bunai, Y; Ishii, A; Nagai, A; Nishida, N; Yamaguchi, S | 1 |
| Li, D; Li, W; Wen, B; Yan, C; Zhao, Y | 1 |
| de Sain-van der Velden, MG; Peters, LW; Smiet, E; van der Kolk, JH | 1 |
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| Adams, SH; Knotts, TA; McCoin, CS; Ono-Moore, KD; Oort, PJ | 1 |
| Baker, PR; Boyle, KE; Friedman, JE; Houmard, JA; Ilkayeva, OR; Koves, TR; Muoio, DM | 1 |
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| Cassol, E; Gabuzda, D; Kirk, GD; Mehta, SH; Misra, V; Morgello, S | 1 |
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| Gong, Z; Lv, Z; Tian, GL; Xu, WJ; Zhang, T | 1 |
| Cirule, H; Dambrova, M; Grinberga, S; Kuka, J; Liepinsh, E; Makarova, E; Makrecka-Kuka, M; Sevostjanovs, E; Vilskersts, R; Volska, K | 1 |
| Deutz, NE; Houten, SM; Schooneman, MG; Soeters, MR; Ten Have, GA; van Vlies, N | 1 |
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| Blair, HC; Papachristou, DJ; Sepulveda, J | 1 |
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| Berger, R; Dane, AD; Hankemeier, T; Harms, AC; Koster, MP; Kuc, S; Pennings, JL; Schielen, PC; Visser, GH; Vreeken, RJ | 1 |
| Davies, MN; DeBalsi, KL; Gooding, JR; Ilkayeva, OR; Koves, TR; Lindeboom, L; Muoio, DM; Schrauwen, P; Schrauwen-Hinderling, VB; Seiler, SE; Stevens, RD; Wittmann, AH; Wong, KE | 1 |
| Bunn, JY; Crain, KI; Ebenstein, DB; Fukagawa, NK; Kien, CL; Koves, TR; Matthews, DE; Muoio, DM; Poynter, ME; Stevens, RD; Tarleton, EK | 1 |
| Chen, QL; Hu, W; Liu, CX; Luo, Z; Zheng, JL; Zhu, QL; Zhuo, MQ | 1 |
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| Al-Dirbashi, OY; Antoun, G; Beauchamp, B; Harper, ME; McIntosh, N; Patti, ME; Quizi, J; Thrush, AB | 1 |
| Daniel, H; Ecker, J; Giesbertz, P; Haag, A; Spanier, B | 1 |
| Alcorn, JF; Bharathi, S; Goetzman, ES; Hirschey, MD; Ilkayeva, OR; McHugh, K; Otsubo, C; Uppala, R; Wang, D; Wang, J; Zou, Y; Zuo, YY | 1 |
| Bakovic, M; Schenkel, LC; Sivanesan, S; Taylor, A; Verbrugghe, A; Wuyts, B; Zhang, J | 1 |
| Hoppel, CL; Ingalls, ST; Kerner, J; Minkler, PE; Stoll, MS | 2 |
| Adamski, J; de Mutsert, R; den Heijer, M; le Cessie, S; Mook-Kanamori, DO; Prehn, C; Rensen, PC; Rosendaal, FR; Suhre, K; van Dijk, KW | 1 |
| Ciapaite, J; Houten, SM; Nicolay, K; Prompers, JJ; van den Broek, NM; Wanders, RJ; Wessels, B | 1 |
| Adams, SH; Knotts, TA; McCoin, CS | 1 |
| Abel, S; Bochnia, M; Glatter, M; Recknagel, S; Sander, J; Schaefer, S; Schusser, GF; Uhlig, A; Vollstedt, S; Wensch-Dorendorf, M; Zeyner, A; Ziegler, J | 1 |
| Adamski, J; Bakker, LE; Boon, MR; Jazet, IM; Mook-Kanamori, DO; Nahon, KJ; Prehn, C; Rensen, PC; van Dijk, KW | 1 |
| Bick, DP; Burrage, LC; Craigen, WJ; Elsea, SH; Gibson, JB; Graham, BH; Lose, EJ; Miller, MJ; Strenk, ME; Sun, Q; Sutton, VR; Wong, LJ; Zhang, VW | 1 |
| Adamski, J; Biermasz, NR; Corssmit, EP; Donga, E; Lammers, GJ; Mook-Kanamori, DO; Prehn, C; Rensen, PC; Romijn, JA; van den Berg, R; van Dijk, JG; van Dijk, KW; van Dijk, M; van Kralingen, KW | 1 |
| Becker, S; Beutner, F; Burkhardt, R; Ceglarek, U; Gross, A; Holdt, LM; Kirsten, H; Kovacs, P; Krohn, K; Scholz, M; Stumvoll, M; Teren, A; Teupser, D; Thiery, J; Tönjes, A | 1 |
| Bo, R; Fukuda, S; Hasegawa, Y; Ishii, A; Kobayashi, H; Mizusawa, H; Ohkubo, T; Purevsuren, J; Shigematsu, Y; Shioya, A; Sugie, H; Takahashi, T; Taketani, T; Takuma, H; Tamaoka, A; Tsunemi, T; Watanabe, M; Yamada, K; Yamaguchi, S; Yokota, T | 1 |
| Dávalos-Aranda, G; López-Saldaña, LA; López-Uriarte, GA; Martínez-de-Villarreal, LE; Ponce-García, G; Rodríguez-Sánchez, IP; Ruiz-Herrera, Mdel C; Torres-Sepúlveda, Mdel R; Treviño-Alvarado, VM; Villarreal-Pérez, JZ; Zamora-Ávila, DE | 1 |
| Bo, R; Hasegawa, Y; Ishige, N; Kobayashi, H; Nakamura, M; Takahashi, T; Yamada, K; Yamaguchi, S | 1 |
| De Jesús, VR; Haynes, CA | 1 |
| Ali, S; Begley, P; Cooper, GJ; Dowsey, AW; Dunn, WB; Freeman, OJ; Gardiner, NJ; Hollywood, KA; Petersen, RS; Rustogi, N; Unwin, RD | 1 |
| Chakraborty, P; Ducharme, R; Hawken, S; Little, J; Potter, BK; Walker, M; Wilson, K | 1 |
| Bain, JR; Craig, D; Grass, E; Gregory, SG; Hauser, ER; Haynes, C; Kraus, WE; Krupp, D; Kwee, L; Muehlbauer, M; Muoio, DM; Newgard, CB; Qin, X; Shah, SH; Slentz, DH; Stevens, R | 1 |
| Brunengraber, H; Roe, CR | 1 |
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| Allen, BG; Bouchard, B; Carpentier, AC; Coderre, L; Daneault, C; Des Rosiers, C; Gaestel, M; Gillis, MA; Houde, V; Lachance, D; Martel, C; Ruiz, M; Thompson Legault, J | 1 |
| Gotoh, K; Hotta, Y; Ito, T; Kataoka, T; Kimura, K; Maeda, Y; Nakajima, Y; Shirai, N; Sugiyama, N | 1 |
| Burrage, LC; Elsea, SH; Graham, BH; Kennedy, AD; Miller, MJ; Sun, Q; Sutton, VR; Wong, LJ | 1 |
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| Dambrova, M; Grinberga, S; Kuka, J; Liepinsh, E; Makarova, E; Makrecka-Kuka, M; Sevostjanovs, E; Svalbe, B; Volska, K | 1 |
| Berberich, SL; Dagle, JM; Ryckman, KK | 1 |
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| Berge, RK; Bjørndal, B; Bohov, P; Bruheim, I; Nordrehaug, JE; Ramsvik, MS; Rostrup, E; Svardal, A | 1 |
| Baer, RJ; Jelliffe-Pawlowski, LL; Norton, ME; Rutherford, GW; Santos, N | 1 |
| Buss, C; Entringer, S; Hellmuth, C; Koletzko, B; Lindsay, KL; Uhl, O; Wadhwa, PD | 1 |
| Chen, W; Dong, J; Li, H; Wang, M; Wang, S; Yang, R; Zhang, C; Zhang, L; Zhang, T; Zhao, H; Zhou, W | 1 |
| Nguyen, PJ; Perrin, Y; Rippa, S; Rossez, Y | 1 |
| Ahmad, T; Bowles, DE; Donahue, MP; Felker, GM; Fiuzat, M; Hellkamp, AS; Ilkayeva, OR; Kelly, JP; Kraus, WE; McGarrah, RW; Milano, CA; O'Connor, CM; Patel, CB; Rogers, JG; Samsky, MD; Shah, SH; Testani, JM; Verma, A; Wang, TS | 1 |
| Cusi, K; Garrett, TJ; Kalavalapalli, S; Martinez, J; Mathew, JT; McDougall, DJ; Nautiyal, M; Patterson, RE; Reinhard, MK; Rocca, JR; Sunny, NE; Williams, CM; Yost, RA | 1 |
| Boeing, H; Floegel, A; Johnson, T; Kaaks, R; Kühn, T; Otto, W; Rolle-Kampczyk, U; Sookthai, D; von Bergen, M | 1 |
| Elliott, CT; Graham, SF; Green, BD; Hölscher, C; Kehoe, PG; McClean, PL; McGuinness, B; Nasaruddin, MB; Pan, X; Passmore, AP | 1 |
| Gopalan, V; Lee, SS; Othman, R; Phang, BH; Sabapathy, K; Teoh, WW; Toh, HC; Velan, SS; Verma, SK; Wang, WW; Yaligar, J | 1 |
| Esmaeeli, M; Ghaneh Sherbaf, F; Horri, M; Jahanshahi, S; Moeenolroayaa, G; Mottaghi Moghadam Shahri, H; Naseri, M; Pour Hasan, M; Rasoli, Z; Salemian, F | 1 |
| Brunelli, L; Caironi, P; Cambiaghi, A; Ferrario, M; Gattinoni, L; Giordano, S; Guatteri, L; Latini, R; Masson, S; Pastorelli, R; Raimondi, F; Ristagno, G | 1 |
| Arnemo, JM; Bäckhed, F; Fröbert, O; Ilkayeva, O; Josefsson, J; Kindberg, J; Newgard, CB; Sommer, F; Ståhlman, M | 1 |
| Aguilar-Salinas, CA; Cruz-Bautista, I; Del Bosque-Plata, L; Pallares-Méndez, R | 1 |
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| Adams, SH; Gillingham, MB; Knotts, TA; Matern, D; McCoin, CS; Piccolo, BD; Vockley, J | 1 |
| Bekhof, J; de Koning, TJ; Derks, TG; Heiner Fokkema, MR; Koolhaas, GD; Schielen, PC; van Rijt, WJ; van Spronsen, FJ; Visser, G | 1 |
| Andrew, B; Bezuidenhout, N; George, S; Maarman, G; Madlala, HP; Mendham, A; Ojuka, E; Osiki, PO | 1 |
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| Adamski, J; Ribič-Pucelj, M; Rižner, TL; Vouk, K | 1 |
| Chan, JF; Chow, WN; Curreem, SO; Ding, VS; Ho, DT; Hung, IF; Ke, TY; Lam, CW; Lau, SK; Lee, KC; Lo, GC; Sridhar, S; Sze, KH; To, KK; Wong, SC; Woo, PC; Yuen, KY | 1 |
| Antone, U; Dambrova, M; Kuka, J; Liepinsh, E; Makarova, E; Makrecka-Kuka, M; Sevostjanovs, E; Strods, A; Tars, K; Vilskersts, R; Volska, K | 1 |
| Bain, JR; Cohen, HJ; Huffman, KM; Kraus, VB; Kraus, WE; Morey, MC; Newgard, CB; Pieper, CF; Ravussin, E; Redman, LM; Stevens, RD; Thompson, DK | 1 |
| Armitage, EG; Barbas, C; Bolkun, L; Ciborowski, M; Ferrarini, A; Kloczko, J; Kretowski, A; Kulczynska, A; Piszcz, J; Rupérez, FJ; Urbanowicz, A | 1 |
| Akamizu, T; Ariyasu, H; Bando, M; Hosoda, H; Iwakura, H; Kangawa, K; Koyama, H; Nakao, K; Shigematsu, Y | 1 |
| Fu, HX; He, JJ; Jin, M; Lin, MT; Liu, XY; Wang, DN; Wang, N; Wang, ZQ | 1 |
| Acquaviva-Bourdain, C; Attarian, S; Bassez, G; Béhin, A; Brivet, M; Eymard, B; Fouilhoux, A; Kaminsky, P; Labarre-Villa, A; Laforêt, P; Laquerrière, A; Pérard, L; Pouget, J; Rigal, O; Souvannanorath, S; Streichenberger, N; Vanhulle, C; Vianey-Saban, C | 1 |
| Elsemman, IE; Mardinoglu, A; Nielsen, J; Shoaie, S; Soliman, TH | 1 |
| Fukuda, S; Hasegawa, Y; Kobayashi, H; Purevsuren, J; Takahashi, T; Yamada, K; Yamaguchi, S | 1 |
| Arós, F; Clish, CB; Corella, D; Dennis, C; Estruch, R; Fiol, M; Fitó, M; Guasch-Ferré, M; Hruby, A; Hu, FB; Lapetra, J; Martínez-González, MA; Morales-Gil, IM; Ros, E; Ruiz-Canela, M; Salas-Salvadó, J; Serra-Majem, L; Zheng, Y | 1 |
| Hollak, CE; Houten, SM; Houtkooper, RH; Schooneman, MG; Soeters, MR; Vaz, FM; Wanders, RJ | 1 |
| Chen, XX; Fu, W; Li, XW; Liu, J; Zhang, WQ | 1 |
| Dijkstra, IM; Engelen, M; Engelen-Lee, JY; Goldhaber-Pasillas, D; Kemp, S; Kulik, W; Ofman, R; Schackmann, M; Schauer, N; van de Beek, MC; van Lenthe, H; Vaz, FM; Wanders, RJ | 1 |
| Li, W; Ni, J; Wu, L; Xu, L | 1 |
| Harder, U; Hellmuth, C; Kirchberg, FF; Koletzko, B; Nathanielsz, PW; Peissner, W; Uhl, O | 1 |
| Culver, J; Jenkins, CA; Koethe, JR; Petucci, C; Shepherd, BE; Sterling, TR | 1 |
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| Choi, YD; Choi, YH; Jeong, P; Kang, HW; Kim, IY; Kim, J; Kim, WJ; Kim, WT; Kim, YH; Lee, IS; Moon, SK; Park, S; Yan, C; Yun, SJ | 1 |
| Angiolillo, A; Corbi, G; Corso, G; Cristofano, A; Di Costanzo, A; Intrieri, M; La Marca, G; Russo, C; Sapere, N; Scapagnini, G; Vitale, M | 1 |
| Bhanu Prakash, KN; Gopalan, V; Hirayama, M; Horiguchi, T; Ishino, S; Kamiguchi, H; Kaneko, M; Lee, SS; Michael, N; Nishimoto, T; Sadananthan, SA; Satomi, Y; Velan, SS; Yaligar, J; Yang, AY; Zhou, Z; Zhu, B | 1 |
| Arnold, GL; Berry, SA; Cameron, C; Edick, MJ; Hansen, J; Leslie, N; Mohsen, AW; Pena, LD; van Calcar, SC; Vockley, J; Walsh Vockley, C | 1 |
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| Choi, J; Lee, J; Scafidi, S; Wolfgang, MJ | 1 |
| Fievez, V; Hesta, M; Jeusette, I; Nguyen, P; Rochus, K; Rybachuk, G; Wambacq, W; Wuyts, B | 1 |
| Barsch, A; Fuchser, J; Haas, J; Knebel, B; Kotzka, J; Lange, S; Lehr, S; Mack, S; Müller-Wieland, D; Schiller, M; Zurek, G | 1 |
| Amory, H; Baise, E; Boemer, F; Cassart, D; Lemieux, H; Marcillaud-Pitel, C; Serteyn, D; van Galen, G; van Loon, G; Votion, DM | 1 |
| Gao, X; Hu, FB; Hu, Y; Jin, Q; Li, H; Li, R; Liang, L; Lin, X; Liu, Y; Ma, Y; Sun, L; Wang, F; Wu, J; Yao, P; Zeng, R; Zhang, H | 1 |
| Ambler, GK; Hollak, CE; Houten, SM; Miller, SR; Murgatroyd, PR; Napolitano, A; Nunez, DJ; Schooneman, MG; Soeters, MR; Tan, CY; Vidal-Puig, A; Virtue, S | 1 |
| Albert, JS; Kratz, LE | 1 |
| Adam-Vizi, V; Adams, D; Araki, K; Araki, M; Chinopoulos, C; Doczi, J; Gál, A; Ilin, P; Iordanov, I; Ito, H; Kacso, G; Madgar, O; Miller, C; Molnár, MJ; Nagy, Z; Nakahara, M; Németh, B; Ostergaard, E; Patocs, A; Ravasz, D; Saada, A; Vargedo, Z | 1 |
| Gang, X; Han, Q; Liu, Y; Sun, C; Wang, G; Zhao, X | 1 |
| Bo, R; Fukuda, S; Hasegawa, Y; Kobayashi, H; Mushimoto, Y; Purevsuren, J; Takahashi, T; Taketani, T; Yamada, K; Yamaguchi, S | 1 |
| Britton, SL; Burgess, SC; Fletcher, JA; Fu, X; Ibdah, JA; Koch, LG; Meers, GM; Morris, EM; Rector, RS; Shankar, K; Thyfault, JP | 1 |
| Abate, N; Asghar, R; Brasier, AR; Camacho-Hughes, M; Chondronikola, M; Dillon, EL; Durham, WJ; Porter, C; Sheffield-Moore, M; Sidossis, L; Tuvdendorj, D; Volpi, E; Wu, Z; Zhang, X; Zhao, Y | 1 |
| Hagiwara, SI; Kagimoto, S; Kubota, M; Nambu, R | 1 |
| Chen, S; Clemmesen, JO; Hansen, JS; Häring, HU; Hoene, M; Lehmann, R; Pedersen, BK; Plomgaard, P; Secher, NH; Wang, XL; Weigert, C; Xu, G; Zhao, XJ | 1 |
| Björck, I; de Mello, VD; Hanhineva, K; Johansson, M; Lehtonen, M; Nilsson, A; Paananen, J; Tovar, J | 1 |
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| Consitt, LA; Houmard, JA; Koves, TR; Muoio, DM; Nakazawa, M; Newton, CA | 1 |
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| Acquaviva, C; Bertrand-Michel, J; Capel, F; Cheraiti, N; Hénique, C; Morio, B; Prip-Buus, C; Vianey-Saban, C | 1 |
| Adams, SH; Burnett, DJ; Campbell, C; Casazza, GA; Chandler, CJ; Fernandez, JR; Fiehn, O; Garvey, WT; Harper, ME; Hoppel, CL; Hughen, RW; Hunter, GR; Keim, NL; Light, AR; Newman, JW; Souza, EC; Zhang, J | 1 |
| Cai, R; Chen, DY; Huang, JW; Li, ZT; Tan, JQ; Yan, TZ | 1 |
| Ärlestig, L; Rantapää-Dahlqvist, S; Surowiec, I; Trygg, J | 1 |
| Adams, SH; Anishkin, A; Chintapalli, SV; Gundampati, R; Jayanthi, S; Mallipeddi, PL; Suresh Kumar, TK; van Rossum, DB | 1 |
| Adamski, J; Emeny, RT; Frantz, S; Giegling, I; Greiser, KH; Haerting, J; Kastenmüller, G; Kluttig, A; Lacruz, ME; Medenwald, D; Prehn, C; Rujescu, D; Tiller, D | 1 |
| Cowan, TM; Enns, GM; Jelliffe-Pawlowski, LL; Kastenberg, ZJ; Moss, RL; Ryckman, KK; Scharfe, C; Shaw, GM; Sinclair, TJ; Stevenson, DK; Sylvester, KG | 1 |
| Chen, M; Jiang, J; Liang, J; Liu, Q; Shen, W; Wei, R; Wu, J; Yin, A; Zhong, M | 1 |
| Bakker, BM; Bleeker, A; Derks, TG; Gerding, A; Groen, AK; Heiner, RM; Martines, AM; Niezen-Koning, KE; Permentier, H; Reijngoud, DJ; van Eunen, K; van Rijt, WJ; Volker-Touw, CM; Wolters, JC | 1 |
| Ahn, YT; Jee, SH; Kang, M; Kim, M; Kim, MS; Lee, JH; Sim, JH; Yoo, HJ | 1 |
| Alam, S; Gupta, PK; Khanna, R; Rawat, D; Sarin, SK; Sharma, S; Sood, V | 1 |
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| Black, WC; Delgado-Enciso, I; Flores-Suárez, AE; Gomez-Govea, MA; Lopez-Monroy, B; López-Uriarte, GA; Martin-Park, A; Martínez de Villarreal, LE; Martinez-Fierro, ML; Ponce-Garcia, G; Rodríguez-Sanchez, IP; Ruiz-Herrera, MD; Torres-Sepúlveda, MD; Treviño-Alvarado, VM; Villanueva-Segura, OK; White, GS | 1 |
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| Becker, LB; Choi, J; Choudhary, RC; Hayashida, K; Kim, J; Kim, N; Nishikimi, M; Shoaib, M; Stevens, JF; Yagi, T; Yin, T | 1 |
| Chan, AW; Ching, J; Kovalik, JP; Matchar, DB; Ng, TKS | 1 |
| Barbas, C; de la Fuente, AG; Godzien, J; Gradillas, A; López-Gonzálvez, Á; Mamani-Huanca, M; Otero, A | 1 |
| Bertino, G; Bonfiglio, C; Catania, VE; Malaguarnera, G; Malaguarnera, M; Vicari, E | 1 |
| Belanger-Quintana, A; Bellusci, M; Bergua Martínez, A; Blanco Soto, P; Cambra Conejero, A; Cañedo Villarroya, E; Chumillas Calzada, S; García Silva, MT; Martín Rivada, Á; Martín-Hernández, E; Martínez Figueras, L; Martínez-Pardo Casanova, M; Moráis López, A; Ortiz Temprado, A; Palomino Pérez, L; Pedrón Giner, C; Pérez González, B; Quijada Fraile, P; Ruano, MLF; Ruiz-Salas, P; Stanescu, S; Ugarte, M | 1 |
| Haga, M; Isobe, M; Kawabata, K; Mochizuki, H; Shimizu, M | 1 |
| Chen, C; Hsieh, TY; Hsu, MH; Hung, KY; Hung, PL; Kuo, HC; Lin, JL; Lin, YJ | 1 |
| Babio, N; Bhupathiraju, SN; Clish, CB; Corella, D; Dennis, C; Drouin-Chartier, JP; Estruch, R; Fitó, M; Guasch-Ferré, M; Hernández-Alonso, P; Hu, FB; Li, J; Liang, L; Martínez-González, MA; Razquin, C; Ros, E; Ruiz-Canela, M; Salas-Salvadó, J; Toledo, E; Wittenbecher, C | 1 |
| Aldehaimi, A; Almannai, M; Almontashiri, NAM; Peake, RWA | 1 |
| Baraniuk, JN; Cheema, A; Kern, G; Narayan, V | 1 |
| Berman, LM; Brown, LD; Hendricks, AE; Krebs, NF; Tang, M; Weaver, NE | 1 |
| De Smet, S; De Spiegeleer, M; De Vos, WH; Goethals, S; Rombouts, C; Van Hecke, T; Van Meulebroek, L; Vanhaecke, L | 1 |
| Buño, A; Caballero, FF; Lana, A; Lopez-Garcia, E; Rodríguez-Artalejo, F; Struijk, EA | 1 |
| Chen, Y; Lin, Q; Liu, G; Qiu, X; Zeng, Y; Zhu, W | 1 |
| Bucci, I; Cicalini, I; De Laurenzi, V; Di Michele, S; Dionisi-Vici, C; Pieragostino, D; Rizzo, C; Rossi, C; Semeraro, D; Stuppia, L; Verrocchio, S; Zucchelli, M | 1 |
| Gadgil, MD; Herrington, DM; Kanaya, AM; Kandula, NR; Lewis, MR; Sands, C | 1 |
| Bergman, BC; Broussard, JL; Brozinick, JT; Bui, HH; D'Alessandro, A; Harrison, K; Macias, E; Milligan, P; Nemkov, T; Newsom, SA; Perreault, L; Roth, KD | 1 |
| Feng, C; Gonzalez, FJ; Jin, Y; Lu, D; Qiu, X; Wang, G; Xue, L; Zhou, Z | 1 |
| Fu, M; Guo, R; Li, HR; Niu, Z; Ren, HH; Yao, L; Zhang, XY | 1 |
| Ahmed, AT; Arnold, M; Baillie, RA; Bhattacharyya, S; Craighead, WE; Dunlop, BW; Frye, MA; Han, X; John-Williams, LS; Kaddurah-Daouk, R; Krishnan, R; Louie, G; MahmoudianDehkordi, S; McDonald, W; Moseley, MA; Riva-Posse, P; Rush, AJ; Skime, MK; Thompson, JW; Weinshilboum, RM | 1 |
| Daimon, S; Nishitani, M; Yasuda, M | 1 |
| Hu, R; Li, X; Li, Y; Liang, Y; Liu, Y; Xu, W | 1 |
| Chang, LC; Huang, JW; Kuo, CH; Kuo, HC; Shih, JY; Tsai, TW | 1 |
| Auriola, S; Hanhineva, K; Karhunen, PJ; Kärkkäinen, O; Kok, E; Kokla, M; Lehtonen, M; Martiskainen, M; Tiihonen, J | 1 |
| Ahima, RS; Ankrum, J; Anokye-Danso, F; Bhardwaj, G; Fink, B; Greenberg, AS; Harata, M; Imai, Y; Jackson, L; Kang, C; King, T; Liu, S; Mishra, A; O'Neill, BT; Promes, J; Sah, R; Sivitz, W; Stephens, S; Strack, S | 1 |
| Carbone, J; Castro-Pearson, S; Griffin, TJ; Kan, V; Koulouris, N; Neaton, JD; Pett, S; Proper, J; Reilly, C; Wendt, CH | 1 |
| Chen, D; Chen, Z; Fu, Q; Lin, C; Lin, W; Lin, Y; Peng, W; Zhang, W | 1 |
| Chen, L; Cheng, L; Deepak, RNVK; Deng, H; Fan, H; Jiao, Y; Kee, K; Kuang, W; Lan, Z; Li, W; Liu, C; Liu, X; Luo, Q; Ma, Z; Meng, X; Meng, Z; Wang, W; Wang, X; Xu, L; Zhang, J; Zhao, X | 1 |
| Elmsjö, A; Green, H; Kugelberg, FC; Söderberg, C; Vikingsson, S | 1 |
| Azzout-Marniche, D; Khodorova, NV; Kok, FJ; Mensink, M; Piedcoq, J; Pilard, S; Rietman, A; Rutledge, DN; Schwarz, J; Siebelink, E; Tomé, D | 1 |
| Dagogo-Jack, S; Owei, I; Stentz, F; Umekwe, N; Wan, J | 1 |
| Dabaj, I; Imbard, A; Snanoudj, S; Sudrié-Arnaud, B; Tebani, A | 1 |
| Caudal, A; Kolwicz, SC; McMillen, TS; Ritterhoff, J; Senn, T; Tian, R; Villet, O; Young, S | 1 |
| Balasubramanyam, A; Bennet, R; Caducoy, E; Gaba, R; Hsu, JW; Jahoor, F; Keene, KR; Lernmark, A; Mehta, PB; Mulukutla, SN; Patel, SG; Peacock, WF | 1 |
| Abdul Azees, PA; Barnes, JL; Das, F; Ghosh Choudhury, G; Kamat, A; Katz, MS; Pizzini, J; Shi, Y; Wang, H; Weintraub, ST; Yeh, CK; Zang, M | 1 |
| Aitken-Buck, HM; Bunton, RW; Coffey, S; Davis, PJ; Jones, PP; Krause, J; Lamberts, RR; Parry, DJ; van Hout, I; Williams, MJA; Zeller, T | 1 |
| Chew, H; Ching, J; Chow, VJ; Ewe, SH; Gao, F; Keng, BM; Koh, AS; Koh, WP; Kovalik, JP; Lee, LS; Leng, S; Tan, HC; Tan, RS; Tan, TY; Teo, LL; Zhao, X; Zhong, L | 1 |
| Dambrova, M; Grandane, A; Katkevics, M; Liepinsh, E; Makrecka-Kuka, M; Sevostjanovs, E; Videja, M; Vilks, K | 1 |
| Aquarius, M; Arts, ICW; Bours, MJL; Breukink, SO; Gicquiau, A; Gunter, MJ; Keulen, ETP; Leitzmann, MF; Rinaldi, S; Scalbert, A; van Delden, L; van Roekel, EH; Viallon, V; Vineis, P; Weijenberg, MP | 1 |
| Liao, AH; Liu, H; Luo, J; Mor, G; Shen, L; Wang, LL; Xie, T; Zhao, SJ | 1 |
| Dänicke, S; Frahm, J; Grindler, S; Huber, K; Kenéz, Á; Xu, W | 1 |
| Bain, J; Felker, GM; Giamberardino, SN; Ilkayeva, O; Kraus, WE; McGarrah, RW; Newgard, CB; O'Connor, CM; Regan, JA; Shah, SH; Truby, LK | 1 |
| Hinkle, SN; Liang, L; Lin, Y; Rawal, S; Tsai, MY; Weir, NL; Wu, J; Zhang, C; Zhu, Y | 1 |
| Art, T; Boemer, F; Davis, MS; Tosi, I; Votion, DM | 1 |
| Akbaş, SH; Başak Oktay, S; Özen Küçükçetin, İ; Toru, HS; Yilmaz, VT; Yücel, SG | 1 |
| Bester, J; Davoren, E; du Preez, I; Kruger, Y; Swanepoel, A | 1 |
| Bayissa, TN; Geerardyn, M; Janssens, GPJ; Vanhauteghem, D; Wakjira, M | 1 |
| Abcouwer, SF; Afshinnia, F; Byun, J; Fort, PE; Gardner, TW; Kretzler, M; Looker, HC; Michailidis, G; Nelson, RG; Pennathur, S; Rajendiran, TM; Roger, JE; Shan, Y; Soni, T | 1 |
| Gahr, BM; Just, S; Krause, J; Park, DD; Rottbauer, W; Zeller, T | 1 |
| Jiao, Y; Li, S; Li, W; Tang, T; Tian, Y; Xu, D; Xu, F; Zhang, P; Zhang, Z | 1 |
| Akpan, IJ; Buehler, PW; Cendali, FI; D'Alessandro, A; Francis, RO; Gamboni, F; Hod, EA; Hudson, KE; Kahn, S; Katneni, U; Moriconi, C; Nemkov, T; Reisz, JA; Roh, D; Spitalnik, SL; Tanaka, K; Thangaraju, K; Thomas, T; Valk, JE; Wei, AZ; Zimring, JC | 1 |
| Adam, T; Chrastina, P; Farolfi, M; Foltenová, H; Friedecký, D; Hanák, P; Honzík, T; Hrubá, E; Ješina, P; Kousal, B; Kožich, V; Pavlíková, M; Rücklová, K; Smolka, V; Vlášková, H; Zeman, J | 1 |
| Bremer, AA; Cao, Y; Chen, L; Chen, Z; Gelaye, B; Grantz, KL; Hinkle, SN; Li, M; Mitro, SD; Rahman, ML; Song, Y; Tsai, MY; Weir, NL; Wu, J; Zhang, C; Zhu, Y | 1 |
| He, X; Li, Q; Liu, H; Miao, J; Wan, K; Wang, D; Yuan, Z; Zhang, J; Zhu, J; Zou, L | 1 |
| Dean, DA; Dorrestein, PC; Gautham, G; McCall, LI; McKerrow, JH; Siqueira-Neto, JL | 1 |
| Cabrera, D; Falcón-Pérez, JM; Kollmus, H; Pilzner, C; Schughart, K; van Liempd, S | 1 |
| Albillos, SM; Calvo, S; Cubo, E; Montero, O; Solano-Vila, B; Trejo, JM | 1 |
| Li, Y; Lin, X; Liu, X; Ma, Y; Sun, L; Sun, Y; Zeng, R | 1 |
| Ji, W; Tian, G; Wang, S; Wang, Y; Zhang, X | 1 |
| An, ZN; Ge, MH; Jiang, DW; Liu, C; Shen, XL; Wei, DZ; Xing, XJ; Zheng, DM | 1 |
| Dambrova, M; Goldins, NR; Grinberga, S; Groma, V; Kuka, J; Liepinsh, E; Makrecka-Kuka, M; Plaas, M; Sevostjanovs, E; Stelfa, G; Svalbe, B; Vilks, K; Vilskersts, R | 1 |
| Ding, D; Gong, P; Li, W; Wang, N; Wang, X; Wang, Z; Zhang, X | 1 |
| Drake, RR; Louey, S; Thornburg, KL | 1 |
| Agarwal, A; Brantley, MA; Haines, JL; Jones, DP; Ma, C; Mitchell, SL; Pericak-Vance, MA; Scott, WK; Uppal, K | 1 |
| Almanza-Aguilera, E; Alonso-Gómez, Á; Arós, F; Clish, CB; Corella, D; Dennis, C; Estruch, R; Fiol, M; Gómez-Gracia, E; Guasch-Ferré, M; Hernández-Alonso, P; Hu, FB; Lapetra, J; Li, J; Liang, L; Martínez-González, MÁ; Razquin, C; Ros, E; Ruiz-Canela, M; Salas-Salvadó, J; Serra-Majem, L; Toledo, E; Wittenbecher, C | 1 |
| Abily-Donval, L; Bekri, S; Goldenberg, A; Marret, S; Salomons, GS; Snanoudj, S; Sudrié-Arnaud, B; Tebani, A; Torre, S | 1 |
| Griffin, C; Luna, C; Miller, MJ | 1 |
| Borradaile, N; Bureau, Y; Dunlop, K; Hadway, J; Lee, TY; Nygard, K; Regnault, TRH; Richardson, BS; Sarr, O; Stachura, N; Thompson, JA; Zhao, L | 1 |
| Adebayo, AS; Anthony, B; Aujla, H; Dott, W; Eagle-Hemming, B; Griffin, JL; Gulston, M; Joel-David, L; Kumar, T; Lai, FY; Murgia, A; Murphy, GJ; Roman, M; Sheikh, S; Woźniak, MJ; Yusoff, S; Zakkar, M | 1 |
| Deda, O; Gika, H; Karagiannidis, E; Meikopoulos, T; Sianos, G; Theodoridis, G | 1 |
| An, Z; Jiang, D; Liu, C; Wei, D; Xing, X; Zheng, D | 1 |
| Aimo, A; Franco, AD; Morfino, P | 1 |
| Cao, Y; Jiang, Y; Shi, H; Song, W; Wang, Y; Zhang, B; Zhang, Z; Zhu, L | 1 |
| Boemer, F; Cavalier, E; Misset, B; Rousseau, AF; Schmitz, S | 1 |
| Begou, O; Deda, O; Gika, H; Karagiannidis, E; Meikopoulos, T; Mouskeftara, T; Panteris, E; Papazoglou, AS; Sianos, G; Theodoridis, G | 1 |
| Dang, Y; Dong, J; Fan, G; Meng, L; Shen, J; Shi, H; Shi, J; Wang, D; Wu, W; Xi, H; Yang, R; Yu, P | 1 |
| Fang, ZZ; Gao, XQ; Li, X; Liu, X; Wang, WY | 1 |
| Arnold, M; Dehkordi, SM; Dunlop, BW; Kaddurah-Daouk, R; Kastenmüller, G; Krishnan, RR; Milaneschi, Y; Penninx, BWJH; Rush, AJ | 1 |
| Fan, S; Jia, X; OuYang, B; Wang, S; Wu, B; Zhang, N | 1 |
| Alavi-Moghadam, S; Arjmand, B; Dehghanbanadaki, H; Dilmaghani-Marand, A; Farzadfar, F; Ghodssi-Ghassemabadi, R; Hosseinkhani, S; Larijani, B; Mohammadi Fateh, S; Najjar, N; Nasli-Esfahani, E; Razi, F | 1 |
| Aaron, L; Borkowsky, W; Hobbs, C; Kirmse, B; Montepiedra, G; Ryckman, KK; Smith, CJ; Summar, M; Van Dyke, R; Williams, PL; Yu, C | 1 |
| Attwood, MM; Dambrova, M; Guo, AC; Kuka, J; Liepinsh, E; Makrecka-Kuka, M; Nordberg, D; Oler, E; Schiöth, HB; Sen, ZD; Smesny, S; Tian, S; Vilskersts, R; Wishart, DS; Zheng, J | 1 |
| Amiano, P; Ardanaz, E; Chajes, V; Gunter, MJ; Huerta, JM; Hultdin, J; Huybrechts, I; Jakszyn, P; Johnson, T; Katzke, V; Keski-Rahkonen, P; Krogh, V; Pokharel, P; Redondo-Sánchez, D; Rothwell, JA; Sacerdote, C; Sandanger, TM; Santucci de Magistris, M; Scalbert, A; Schmidt, JA; Schulze, MB; Tjønneland, A; Tumino, R; Viallon, V; Wedekind, R; Weiderpass, E; Winkvist, A | 1 |
| Calvano, CD; Cataldi, TRI; Console, L; Giangregorio, N; Incampo, G; Indiveri, C; Marino, T; Prejanò, M; Russo, N; Scalise, M; Tonazzi, A | 1 |
| Honda, M; Honda, Y; Miyagawa, T; Shigematsu, Y; Shimada, M; Tokunaga, K | 1 |
| Calderón-Santiago, M; Luque-Córdoba, D; Priego-Capote, F | 1 |
| Asadi, M; Bandarian, F; Dehghanbanadaki, H; Hosseinkhani, S; Najjar, N; Pasalar, P; Razi, F; Salari, P; Shirani, S | 1 |
| Altay, N; Binici, O; Büyükfırat, E; Duran, E; Gönel, A; Karahan, MA; Koyuncu, I | 1 |
| Feng, T; Kenéz, Á; Mann, S; Nydam, DV; Overton, TR; Wakshlag, JJ; Xu, W; Yepes, FL | 1 |
| Emamgholipour, S; Hosseinkhani, S; Khalagi, K; Larijani, B; Najjar, N; Pasalar, P; Razi, F; Salari, P; Shirani, S | 1 |
| Khatami, S; Lotfi, J; Rabbani, A; Rasaee, MJ; Taghikhani, M | 1 |
| Franke, L; Peters, FT; Wissenbach, DK | 1 |
| Chammas, R; Chuffa, LGA; Junior, RP; Reiter, RJ; Simão, VA; Sonehara, NM; Zuccari, DAPC | 1 |
| Jacobs, A; Jansen Van Vuren, E; Kruger, R; Louw, R; Mels, C; Strauss-Kruger, M | 1 |
| Chen, D; Chen, YM; Fu, Y; Gou, W; Jiang, Z; Liu, CY; Wu, YY; Xie, K; Yan, Y; Yang, Y; Zheng, JS; Zhu, HL | 1 |
| Brumarová, R; Dobešová, D; Friedecký, D; Jahn, P; Kopecká, A; Tóthová, K | 1 |
| De Grassi, A; Giangregorio, N; Incampo, G; Indiveri, C; Pierri, CL; Tonazzi, A; Tragni, V | 1 |
| Clinton Frazee, C; Garg, U; Heese, B; Scott, D | 1 |
| Brose, SA; Hobert, JA; Pasquali, M | 1 |
| Baird, S; Frazee, CC; Garg, U | 1 |
| Canizales-Quinteros, S; Flores, YN; Ibarra-González, I; León-Reyes, G; Palacios-González, B; Rivera-Paredez, B; Salmerón, J; Vela-Amieva, M; Velázquez-Cruz, R | 1 |
| Fu, Z; He, B; Hu, L; Jin, C; Jin, Y; Wang, C; Wang, X | 1 |
| Abali, S; Albayrak, E; Basgoze, S; Beken, S; Bulum, B; Demirelce, O; Erek, E; Guvenc, O; Odemis, E; Saral, NY; Serteser, M; Toygar, AK; Yalcin, G | 1 |
| Li, D; Lu, Y; Wei, L; Yan, L; Yang, K; Yang, X; Yuan, X; Zhao, F | 1 |
| Aktuğlu Zeybek, AÇ; Barut, K; Cansever, MŞ; Kasapçopur, Ö; Kıykım, E; Zübarioğlu, T | 1 |
| Attia, SL; Helsley, RN; Inci, MK; Park, SH; Softic, S | 1 |
| Cai, R; Chang, R; Chen, D; Huang, L; Jiang, Y; Ning, H; Pan, L; Tan, J; Wei, B; Wei, J; Yang, J; Yin, B; Yuan, D; Zeng, T; Zheng, M | 1 |
| Chen, Y; Cheng, X; Li, M; Liang, Z; Tan, X; Wang, W; Weng, X; Wu, M; Wu, X; Zhang, Z; Zhu, P; Zhu, R | 1 |
| Akbay, Hİ; Akmeşe, Ş; Alp, HH; Binici, I; Çelik, H; Gonel, A; Huyut, Z; Karsen, H; Koyuncu, I | 1 |
| Burton, GJ; El-Bacha, T; Ferreira, CS; Goes, VA; Griffin, JL; Guimarães, DAB; Lai, C; Murgia, A; Pinto, GDA; Ranquine, LG; Reis, DL; Struchiner, CJ; Torres, AG | 1 |
| Gika, H; Kotali, A; Theodoridis, K | 1 |
| Hotwani, A; Ilyas, M; Jafri, L; Jehan, F; Khalid, J; Khan, AH; Majid, H; Nisar, I | 1 |
| Abellan-Borja, A; Barboza-Aranda, LJ; Carrera-Treviño, R; Delgado-Enciso, I; Gomez-Govea, MA; Gonzalez-Rojas, JI; Guzman-Velasco, A; Martinez-de-Villareal, LE; Martinez-Fierro, ML; Rodriguez-Sanchez, IP; Ruiz-Ayma, G; Villanueva-Segura, OK; Zapata-Morin, PA | 1 |
| Arjmand, B; Asadi, M; Dehghanbanadaki, H; Dilmaghani-Marand, A; Emamgholipour, S; Ghasemi, E; Ghodssi-Ghassemabadi, R; Hosseinkhani, S; Khoshniat, M; Larijani, B; Najjar, N; Panahi, N; Razi, F; Rezaei, N; Taghizadeh, H | 1 |
| Kim, YA; Kwon, SH; Lee, Y; Park, UC; Seo, JH; Yoo, HJ; Yoon, CK; Yu, HG | 1 |
| Goto, K; Hiramatsu, M; Imai, K; Korematsu, S; Uchiyama, SI; Uemura, A; Wasada, R | 1 |
| Dambrova, M; Grandane, A; Jaudzems, K; Liepinsh, E; Pudnika-Okinčica, L; Sipola, A; Videja, M; Vilks, K; Zelencova-Gopejenko, D | 1 |
| Artiushin, G; Li, F; Sehgal, A | 1 |
| Li, CS; Lu, ZQ; Wang, GX; Xiao, HL; Xie, MR; Zhang, HY | 1 |
| Elgstøen, KBP; Hiller, JK; Moe, MC; Petrovski, G; Rootwelt, H; Sandås, EM; Utheim, TP; Østeby Vassli, A | 1 |
| Dawid, C; Dunkel, A; Ensenauer, R; Hofmann, TF; Kleigrewe, K; Mittermeier-Klessinger, VK; Wudy, SI | 1 |
| Miller, M; Morrissey, M; Rastogi, D; Rastogi, S; Sasenick, J | 1 |
| Console, L; Giangregorio, N; Indiveri, C; Scalise, M; Tonazzi, A | 1 |
| Luo, H; Zhu, Z | 1 |
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| Bie, X; Chen, G; Chen, L; Hao, Y; Liu, H; Liu, X; Ma, X; Shi, X; Yan, W; Yang, F; Yang, J; Yang, X; Zhang, D; Zhang, K; Zhao, D; Zheng, H; Zhu, Z | 1 |
| Aitken-Buck, HM; Jones, PP; Khaing, EP; Lamberts, RR | 1 |
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| Hayashida, S; Isobe, N; Shiraishi, W; Tajima, G; Tateishi, T; Tsumura, M | 1 |
| Abi-Rached, ZH; Jennings, EA; Jones, DE; Ryan, RO | 1 |
| Borum, PR; Broquist, HP | 1 |
| Dewhurst, SA; Weinreich, D | 1 |
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| Fava, M; Mischoulon, D; Papakostas, GI; Sarris, J; Vitolo, O | 1 |
| Aithal, GP; Alvarez-Alvarez, I; Andrade, RJ; Arikan, C; Atallah, E; Lucena, MI; Medina-Caliz, I; Niu, H | 1 |
52 review(s) available for carnitine and s-adenosylmethionine
| Article | Year |
|---|---|
[Fibromyalgia syndrome].
Topics: Biomarkers; Carnitine; Diagnosis, Differential; Fatigue; Fatigue Syndrome, Chronic; Fibromyalgia; Humans; Mood Disorders; Pain; Syndrome | 1999 |
Supplemental carnitine and exercise.
Topics: Carnitine; Coenzyme A; Dietary Supplements; Exercise; Fatty Acids; Female; Humans; Male; Muscle Contraction; Muscle, Skeletal; Oxygen Consumption | 2000 |
[Chronic fatigue syndrome].
Topics: Carnitine; Diagnosis, Differential; Endocrine System Diseases; Fatigue Syndrome, Chronic; Humans; Immune System Diseases; Prognosis; Stress, Physiological; Virus Diseases | 2000 |
[Mitochondrial carnitine acylcarnitine translocase].
Topics: Carnitine; Carnitine Acyltransferases; Energy Metabolism; Fatty Acids; Humans; Mitochondria; Oxidation-Reduction | 2002 |
Application of tandem mass spectrometry to biochemical genetics and newborn screening.
Topics: Amino Acids; Carnitine; Genetic Testing; Humans; Infant, Newborn; Molecular Biology; Neonatal Screening; Peroxisomal Disorders; Spectrometry, Mass, Electrospray Ionization | 2002 |
Prospective diagnosis of 2-methylbutyryl-CoA dehydrogenase deficiency in the Hmong population by newborn screening using tandem mass spectrometry.
Topics: Amino Acid Metabolism, Inborn Errors; Carnitine; Diagnosis, Differential; Diet, Protein-Restricted; DNA Mutational Analysis; Ethnicity; Exons; Female; Genetic Testing; Humans; Infant, Newborn; Intellectual Disability; Isoleucine; Male; Mass Spectrometry; Neonatal Screening; Oxidoreductases Acting on CH-CH Group Donors; Sequence Deletion; Treatment Outcome | 2003 |
Use of tandem mass spectrometry for multianalyte screening of dried blood specimens from newborns.
Topics: Amino Acid Metabolism, Inborn Errors; Amino Acids; Blood Specimen Collection; Carnitine; Hematologic Tests; Humans; Infant, Newborn; Lipid Metabolism, Inborn Errors; Mass Spectrometry | 2003 |
L-carnitine and its possible role in red cell and platelet storage.
Topics: Blood Platelets; Blood Preservation; Carnitine; Erythrocytes; Fatty Acids; Humans; Hydrogen-Ion Concentration; Intracellular Membranes; Mitochondria; Models, Chemical; Oxygen; Platelet Transfusion; Specimen Handling; Temperature; Time Factors | 2004 |
Carnitine-acylcarnitine translocase deficiency: identification of a novel molecular defect in a Bedouin patient.
Topics: Arabs; Carnitine; Carnitine Acyltransferases; Fatal Outcome; Humans; Infant, Newborn; Israel; Male; Metabolism, Inborn Errors; Mutation, Missense; Oxidation-Reduction | 2004 |
Carnitine and peripheral arterial disease.
Topics: Arterial Occlusive Diseases; Carnitine; Humans; Intermittent Claudication; Muscle, Skeletal; Oxygen Consumption | 2004 |
Assays of fatty acid beta-oxidation activity.
Topics: Acids; Biological Transport, Active; Carnitine; Fatty Acids; Glycine; Humans; Lipid Metabolism; Mitochondria; Models, Biological; Oxidation-Reduction | 2007 |
[Chronic fatigue syndrome and neurotransmitters].
Topics: Animals; Carnitine; Fatigue Syndrome, Chronic; Glutamates; Humans; Membrane Proteins; Neurotransmitter Agents; Organic Cation Transport Proteins; Serotonin; Serotonin Plasma Membrane Transport Proteins; Solute Carrier Family 22 Member 5; Synaptic Transmission | 2007 |
[Determination of normal acylcarnitine levels in a healthy pediatric population as a diagnostic tool in inherited errors of mitochondrial fatty acid beta-oxidation].
Topics: Adolescent; Carnitine; Child; Child, Preschool; Fatty Acids; Female; Humans; Infant; Lipid Metabolism, Inborn Errors; Male; Mitochondrial Diseases; Oxidation-Reduction; Reference Values | 2007 |
Is oral L-acyl-carnitine an effective therapy for hepatic encephalopathy? Review of the literature.
Topics: Administration, Oral; Carnitine; Hepatic Encephalopathy; Humans; Randomized Controlled Trials as Topic; Treatment Outcome | 2008 |
Interstitial deletion of 1p22.2p31.1 and medium-chain acyl-CoA dehydrogenase deficiency in a patient with global developmental delay.
Topics: Acyl-CoA Dehydrogenase; Carnitine; Child; Chromosome Deletion; Chromosomes, Human, Pair 1; Dicarboxylic Acids; DNA Mutational Analysis; Exons; Facies; Female; Humans; In Situ Hybridization, Fluorescence; Karyotyping; Mutation, Missense; Oligonucleotide Array Sequence Analysis; Psychomotor Disorders; Seizures | 2008 |
Carnitine, mitochondrial function and therapy.
Topics: Animals; Carnitine; Carnitine Acyltransferases; Heart Diseases; Humans; Mitochondria | 2009 |
Acylcarnitines: role in brain.
Topics: Acetylcarnitine; Animals; Antioxidants; Brain; Carnitine; Energy Metabolism; Fatty Acids; Nerve Growth Factor; Nervous System Diseases; Neuroprotective Agents | 2010 |
Muscle insulin resistance: assault by lipids, cytokines and local macrophages.
Topics: Adipose Tissue; Animals; Carnitine; Cytokines; Dietary Fats; Humans; Insulin; Insulin Resistance; Lipid Metabolism; Macrophages; Muscle, Skeletal; Phosphotransferases; Reactive Oxygen Species; Triglycerides | 2010 |
LC-MS/MS progress in newborn screening.
Topics: Carnitine; Chromatography, Liquid; Humans; Infant, Newborn; Lysosomal Storage Diseases; Neonatal Screening; Tandem Mass Spectrometry | 2011 |
How to use acylcarnitine profiles to help diagnose inborn errors of metabolism.
Topics: Carnitine; Chemistry, Clinical; Child; Humans; Metabolism, Inborn Errors; Pediatrics | 2010 |
Profiling of acylcarnitines and sterols from dried blood or plasma spot by atmospheric pressure thermal desorption chemical ionization (APTDCI) tandem mass spectrometry.
Topics: Atmospheric Pressure; Carnitine; Dried Blood Spot Testing; Humans; Sterols; Tandem Mass Spectrometry; Temperature | 2011 |
Carnitine and acylcarnitines: pharmacokinetic, pharmacological and clinical aspects.
Topics: Animals; Carnitine; Homeostasis; Humans | 2012 |
Application of mass spectrometry in newborn screening: about both small molecular diseases and lysosomal storage diseases.
Topics: Amino Acids; Carnitine; Humans; Infant, Newborn; Lysosomal Storage Diseases; Metabolism, Inborn Errors; Neonatal Screening; Tandem Mass Spectrometry | 2014 |
Universal screening for inherited metabolic diseases in the neonate (and the fetus).
Topics: Acyl-CoA Dehydrogenase; Amino Acids; Carnitine; DNA; DNA Mutational Analysis; Female; Gestational Age; Humans; Infant, Newborn; Metabolism, Inborn Errors; Neonatal Screening; Paper; Phenylketonurias; Pregnancy; Prenatal Diagnosis; Tandem Mass Spectrometry | 2012 |
Acylcarnitines: reflecting or inflicting insulin resistance?
Topics: Animals; Carnitine; Citric Acid Cycle; Fatty Acids; Humans; Insulin Resistance; Lipid Metabolism; Oxidation-Reduction | 2013 |
Separation of carnitine and acylcarnitines in biological samples: a review.
Topics: Animals; Carnitine; Chromatography, Liquid; Electrophoresis, Capillary; Gas Chromatography-Mass Spectrometry; Humans; Liquid-Liquid Extraction; Solid Phase Extraction | 2013 |
Metabolomic biomarkers for obesity in humans: a short review.
Topics: Amino Acids, Branched-Chain; Biomarkers; Carnitine; Case-Control Studies; Cross-Sectional Studies; Humans; Metabolomics; Obesity | 2014 |
Risks and benefits of carnitine supplementation in diabetes.
Topics: Carnitine; Diabetes Mellitus; Dietary Supplements; Humans; Risk | 2015 |
Nature and nurture in atherosclerosis: The roles of acylcarnitine and cell membrane-fatty acid intermediates.
Topics: Animals; Atherosclerosis; Carnitine; Cell Membrane; Dietary Fats; Disease Progression; Erythrocytes; Fatty Acids; Humans; Lipids; Macrophages | 2016 |
Acylcarnitines--old actors auditioning for new roles in metabolic physiology.
Topics: Carnitine; Humans; Lipid Metabolism; Lipid Metabolism, Inborn Errors; Metabolic Diseases; Metabolic Networks and Pathways; Metabolism | 2015 |
Metabolomics in diabetes, a review.
Topics: Amino Acids, Branched-Chain; Animals; Biomarkers; Carnitine; Diabetes Mellitus, Type 2; Humans; Insulin Resistance; Metabolomics; Obesity; Predictive Value of Tests | 2016 |
Inborn Errors of Metabolism That Cause Sudden Infant Death: A Systematic Review with Implications for Population Neonatal Screening Programmes.
Topics: Amino Acids; Autopsy; Carnitine; Humans; Infant; Infant, Newborn; Metabolism, Inborn Errors; Neonatal Screening; Reye Syndrome; Sudden Infant Death | 2016 |
Measurement of β-oxidation capacity of biological samples by respirometry: a review of principles and substrates.
Topics: Acyl Coenzyme A; Carnitine; Coenzyme A; Electrodes; Fatty Acids; Feedback, Physiological; Humans; Malates; Mitochondria; Oxidation-Reduction; Oxidative Phosphorylation; Oxygen Consumption; Palmitoylcarnitine | 2016 |
Association of Plasma Small-Molecule Intermediate Metabolites With Age and Body Mass Index Across Six Diverse Study Populations.
Topics: Aged; Aging; Amino Acids; Body Mass Index; Carnitine; Female; Humans; Male; Metabolomics; Obesity; Plasma | 2016 |
Using Metabolomic Profiles as Biomarkers for Insulin Resistance in Childhood Obesity: A Systematic Review.
Topics: Amino Acids, Aromatic; Amino Acids, Branched-Chain; Biomarkers; Carnitine; Child; Humans; Insulin Resistance; Metabolomics; Pediatric Obesity | 2016 |
Metabolomics for clinical use and research in chronic kidney disease.
Topics: Arginine; Biomarkers; Biomedical Research; Carnitine; Diabetes Mellitus; Humans; Lipid Metabolism; Metabolomics; Oxidative Stress; Renal Insufficiency, Chronic | 2017 |
Do diabetes and obesity affect the metabolic response to exercise?
Topics: AMP-Activated Protein Kinases; Blood Glucose; Carnitine; Diabetes Mellitus, Type 2; Exercise; Fatty Acids; Glucose; Glycogen; Humans; Liver; Muscle, Skeletal; Obesity; Oxidation-Reduction; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; Signal Transduction | 2017 |
Biotin: From Nutrition to Therapeutics.
Topics: Animals; Biotin; Biotinylation; Carnitine; Female; Gene Expression; Hormones; Humans; Multiple Sclerosis; Nutritional Status; Pregnancy; Pregnancy Complications; Streptavidin; Vitamin B Complex | 2017 |
Loading and firing the brown adipocyte.
Topics: Adipocytes, Brown; Adipose Tissue, Brown; Adipose Tissue, White; Animals; Carnitine; Fatty Acids; Glucose; Humans; Uncoupling Protein 1 | 2018 |
Biomarkers for mitochondrial energy metabolism diseases.
Topics: Amino Acids; Biomarkers; Carnitine; Creatine Kinase; Energy Metabolism; Fibroblast Growth Factors; Growth Differentiation Factor 15; Humans; Lactic Acid; Mitochondrial Diseases; Oxidative Phosphorylation; Pyruvic Acid | 2018 |
Physiology of L-carnitine in plants in light of the knowledge in animals and microorganisms.
Topics: Animals; Carnitine; Carnitine Acyltransferases; Fatty Acids; Lipid Metabolism; Mitochondria; Plants | 2018 |
Autologous cord blood in children with cerebral palsy: a review.
Topics: 3-Hydroxybutyric Acid; Amino Acids; Animals; Brain Diseases; Brain Injuries; Carnitine; Cerebral Palsy; Child; Cytokines; Databases, Factual; Fetal Blood; Glycerol; Humans; Hypoxia; Hypoxia-Ischemia, Brain; Intercellular Signaling Peptides and Proteins; Phosphatidylcholines; Phosphorylcholine; Stem Cells; Succinic Acid | 2019 |
Carnitine in Human Muscle Bioenergetics: Can Carnitine Supplementation Improve Physical Exercise?
Topics: Carnitine; Carnitine O-Palmitoyltransferase; Dietary Supplements; Energy Metabolism; Exercise; Fatty Acids; Humans; Methylamines; Mitochondria; Muscle, Skeletal; Oxidation-Reduction | 2020 |
Review: Lipid biology in the periparturient dairy cow: contemporary perspectives.
Topics: Animals; Carnitine; Cattle; Ceramides; Energy Metabolism; Fatty Acids; Female; Glucose; Glycerophospholipids; Insulin; Insulin Resistance; Lactation; Lipid Metabolism; Lipolysis; Liver; Milk; Mitochondria; Signal Transduction; Sphingolipids; Triglycerides | 2020 |
Metabolic interactions between peroxisomes and mitochondria with a special focus on acylcarnitine metabolism.
Topics: Carnitine; Carnitine Acyltransferases; Fatty Acids; Mitochondria; Peroxisomes | 2020 |
Genomics-based identification of a potential causal role for acylcarnitine metabolism in depression.
Topics: Carnitine; Causality; Depression; Genomics; Humans | 2022 |
Acylcarnitines: Nomenclature, Biomarkers, Therapeutic Potential, Drug Targets, and Clinical Trials.
Topics: Biomarkers; Carnitine; Fatty Acids; Humans; Insulin Resistance | 2022 |
Fructose impairs fat oxidation: Implications for the mechanism of western diet-induced NAFLD.
Topics: Animals; Carnitine; Diet, High-Fat; Diet, Western; Dietary Fats; Fructose; Humans; Liver; Non-alcoholic Fatty Liver Disease; PPAR alpha | 2023 |
Acylcarnitines in Ophthalmology: Promising Emerging Biomarkers.
Topics: Biomarkers; Carnitine; Glaucoma, Open-Angle; Humans; Infant, Newborn; Ophthalmology; Vitreous Body | 2022 |
Serum acylcarnitines levels as a potential predictor for gestational diabetes: a systematic review and meta-analysis.
Topics: Carnitine; Child; Diabetes, Gestational; Female; Humans; Mothers; Pregnancy | 2023 |
3-Methylglutarylcarnitine: A biomarker of mitochondrial dysfunction.
Topics: Biomarkers; Carnitine; Humans; Leucine; Mitochondria | 2023 |
Therapeutic Management of Idiosyncratic Drug-Induced Liver Injury and Acetaminophen Hepatotoxicity in the Paediatric Population: A Systematic Review.
Topics: Acetaminophen; Acetylcysteine; Adolescent; Adrenal Cortex Hormones; Adult; Carnitine; Chemical and Drug Induced Liver Injury; Child; Drug-Related Side Effects and Adverse Reactions; Glutathione; Glycyrrhizic Acid; Humans; Infant, Newborn; Liver; Liver Failure, Acute; Retrospective Studies; S-Adenosylmethionine; Ursodeoxycholic Acid | 2022 |
69 trial(s) available for carnitine and s-adenosylmethionine
| Article | Year |
|---|---|
L-carnitine supplementation in patients with cystic acne on isotretinoin therapy.
Topics: Acne Vulgaris; Adult; Alanine Transaminase; Alkaline Phosphatase; Aspartate Aminotransferases; Carnitine; Case-Control Studies; Cholesterol; Female; Follow-Up Studies; Humans; Isotretinoin; Keratolytic Agents; Liver; Male; Muscle Weakness; Muscular Diseases; Pain; Placebos; Triglycerides | 1999 |
Intravenous L-carnitine increases plasma carnitine, reduces fatigue, and may preserve exercise capacity in hemodialysis patients.
Topics: Adult; Aged; Carbon Dioxide; Carnitine; Double-Blind Method; Exercise Test; Exercise Tolerance; Fatigue; Female; Humans; Injections, Intravenous; Kidney Failure, Chronic; Kidney Transplantation; Male; Middle Aged; Models, Biological; Oxygen Consumption; Quality of Life; Renal Dialysis | 2001 |
Metabolic effects in neonates receiving intravenous medium-chain triglycerides.
Topics: Carnitine; Double-Blind Method; Fat Emulsions, Intravenous; Fatty Acids, Nonesterified; Female; Humans; Infant, Newborn; Male; Muscle, Skeletal; Parenteral Nutrition, Total; Triglycerides | 2002 |
Carnitine metabolism in diabetes mellitus.
Topics: Adolescent; Adult; Carnitine; Child; Child, Preschool; Diabetes Mellitus, Type 1; Diabetic Angiopathies; Fatty Acids; Female; Glycated Hemoglobin; Humans; Insulin; Lipids; Lipoprotein(a); Male; Risk Factors | 2002 |
Optimal dietary therapy of long-chain 3-hydroxyacyl-CoA dehydrogenase deficiency.
Topics: 3-Hydroxyacyl CoA Dehydrogenases; Carnitine; Child; Child, Preschool; Diet Therapy; Energy Intake; Fatty Acids; Female; Humans; Infant; Lipid Metabolism, Inborn Errors; Long-Chain-3-Hydroxyacyl-CoA Dehydrogenase; Male; Minerals; Multienzyme Complexes; Treatment Outcome; Vitamins | 2003 |
L-carnitine and exercise tolerance in medium-chain acyl-coenzyme A dehydrogenase (MCAD) deficiency: a pilot study.
Topics: 3-Hydroxybutyric Acid; Acids; Acyl-CoA Dehydrogenase; Adolescent; Adult; Anaerobic Threshold; Blood Glucose; Carnitine; Child; Exercise; Exercise Test; Fatty Acids, Nonesterified; Female; Humans; Lactic Acid; Life Style; Male; Metabolism, Inborn Errors; Pilot Projects | 2005 |
Metabolic effects of intravenous LCT or MCT/LCT lipid emulsions in preterm infants.
Topics: 3-Hydroxybutyric Acid; alpha-Linolenic Acid; alpha-Tocopherol; Body Weight; Carbon Isotopes; Carnitine; Cholesterol; Double-Blind Method; Fat Emulsions, Intravenous; Fatty Acids; Fatty Acids, Essential; Fatty Acids, Nonesterified; Fatty Acids, Unsaturated; Female; gamma-Tocopherol; Humans; Infant, Newborn; Infant, Premature; Lipid Metabolism; Male; Phospholipids; Triglycerides | 2006 |
Demographic and nutritional factors associated with prolonged cholestatic jaundice in the premature infant.
Topics: Amino Acids; Birth Weight; Carnitine; Dietary Supplements; Gestational Age; Glucocorticoids; Humans; Infant; Infant, Newborn; Infant, Premature; Jaundice, Obstructive; Logistic Models; Parenteral Nutrition | 2008 |
The risk of asymptomatic hyperammonemia in children with idiopathic epilepsy treated with valproate: relationship to blood carnitine status.
Topics: Adolescent; Ammonia; Anticonvulsants; Carnitine; Child; Epilepsy; Female; Humans; Hyperammonemia; Male; Prospective Studies; Valproic Acid; Vitamin B Complex | 2009 |
Effect of triheptanoin on muscle metabolism during submaximal exercise in horses.
Topics: Analysis of Variance; Animals; Blood Glucose; Carbohydrate Metabolism; Carnitine; Corn Oil; Cross-Over Studies; Horses; Insulin; Lipid Metabolism; Muscle, Skeletal; Physical Conditioning, Animal; Random Allocation; Triglycerides | 2009 |
Relationship between carnitine, fatty acids and insulin resistance.
Topics: Carnitine; Carnitine O-Acetyltransferase; Carnitine O-Palmitoyltransferase; Diabetes, Gestational; Fatty Acids, Nonesterified; Female; Gene Expression Regulation; Humans; Infant, Newborn; Insulin Resistance; Monocytes; Organic Cation Transport Proteins; Pregnancy; Pregnancy Trimester, Second; RNA, Messenger; Solute Carrier Family 22 Member 5 | 2009 |
Short-term effects of dietary fatty acids on muscle lipid composition and serum acylcarnitine profile in human subjects.
Topics: Adipose Tissue; Carnitine; Dietary Fats; Dose-Response Relationship, Drug; Female; Humans; Male; Muscle, Skeletal; Oleic Acid; Oxidation-Reduction; Palmitic Acid; Triglycerides | 2011 |
Medium chain acylcarnitines dominate the metabolite pattern in humans under moderate intensity exercise and support lipid oxidation.
Topics: Adult; Animals; Carnitine; Cells, Cultured; Chromatography, High Pressure Liquid; Exercise; Humans; In Vitro Techniques; Lipid Metabolism; Magnetic Resonance Spectroscopy; Male; Mass Spectrometry; Mice; Muscle Fibers, Skeletal; Muscle, Skeletal; Oxidation-Reduction; Reverse Transcriptase Polymerase Chain Reaction | 2010 |
L-carnitine supplementation and adipokines in patients with end-stage renal disease on regular hemodialysis.
Topics: Adipokines; Aged; Aged, 80 and over; Arteriosclerosis; Carnitine; Female; Humans; Infusions, Intravenous; Insulin; Kidney Failure, Chronic; Male; Middle Aged; Renal Dialysis; Time Factors | 2010 |
Effect of caloric restriction with and without exercise on metabolic intermediates in nonobese men and women.
Topics: Adiposity; Adult; Aging; Amino Acids; Body Composition; Caloric Restriction; Carnitine; Cross-Sectional Studies; Data Interpretation, Statistical; Exercise; Fatty Acids; Female; Humans; Insulin Resistance; Male; Metabolism; Middle Aged; Overweight; Principal Component Analysis; Sex Characteristics; Spectrum Analysis; Weight Loss | 2011 |
Differential metabolic impact of gastric bypass surgery versus dietary intervention in obese diabetic subjects despite identical weight loss.
Topics: Adult; Amino Acids, Branched-Chain; Carnitine; Cohort Studies; Diabetes Mellitus, Type 2; Female; Gastric Bypass; Humans; Male; Metabolic Networks and Pathways; Middle Aged; Obesity; Principal Component Analysis; Regression Analysis; Weight Loss | 2011 |
Impaired fasting tolerance among Alaska native children with a common carnitine palmitoyltransferase 1A sequence variant.
Topics: Alaska; American Indian or Alaska Native; Body Mass Index; Carnitine; Carnitine O-Palmitoyltransferase; Child, Preschool; Fatty Acids, Nonesterified; Gas Chromatography-Mass Spectrometry; Homozygote; Humans; Hypoglycemia; Ketones; Lipid Metabolism, Inborn Errors; Polymorphism, Single Nucleotide; Tandem Mass Spectrometry | 2011 |
Postprandial changes in plasma acylcarnitine concentrations as markers of fatty acid flux in overweight and obesity.
Topics: Adult; Aged; Biological Transport; Biomarkers; Body Composition; Carnitine; Fatty Acids; Female; Humans; Lipid Metabolism; Male; Middle Aged; Obesity; Osmolar Concentration; Overweight; Postprandial Period; Young Adult | 2012 |
The metabolic effects of two different lipid emulsions used in parenterally fed premature infants--a randomized comparative study.
Topics: Body Weight; Carnitine; Emulsions; Fat Emulsions, Intravenous; Female; Gestational Age; Humans; Infant, Newborn; Infant, Premature; Lipids; Male; Metabolism; Parenteral Nutrition; Phospholipids; Plant Oils; Soybean Oil | 2012 |
Caloric restriction alters the metabolic response to a mixed-meal: results from a randomized, controlled trial.
Topics: Adult; Amino Acids; Caloric Restriction; Carnitine; Energy Intake; Exercise; Fasting; Fatty Acids, Nonesterified; Female; Glucose Tolerance Test; Humans; Insulin Resistance; Male; Middle Aged; Overweight; Postprandial Period; Principal Component Analysis | 2012 |
Free carnitine and acylcarnitines in obese patients with polycystic ovary syndrome and effects of pioglitazone treatment.
Topics: Adult; Carnitine; Female; Humans; Hypoglycemic Agents; Obesity; Pioglitazone; Polycystic Ovary Syndrome; Single-Blind Method; Thiazolidinediones; Treatment Outcome | 2012 |
Metabolomic profiling of urine: response to a randomised, controlled feeding study of select fruits and vegetables, and application to an observational study.
Topics: Adult; Biomarkers; Brassicaceae; Carnitine; Citrus; Cross-Sectional Studies; Diet; Diet Records; Fatty Acids; Feeding Behavior; Female; Fruit; Glycine max; Humans; Ions; Male; Metabolome; Metabolomics; Niacin; Nutrition Assessment; Phytochemicals; Proline; Riboflavin; Surveys and Questionnaires; Vegetables; Young Adult | 2013 |
Metabolomic analysis reveals extended metabolic consequences of marginal vitamin B-6 deficiency in healthy human subjects.
Topics: Acetates; Adult; Amino Acids; Carnitine; Cystathionine; Female; Glutamic Acid; Glutamine; Humans; Ketoglutaric Acids; Male; Metabolomics; Proline; Pyridoxal Phosphate; Vitamin B 6; Vitamin B 6 Deficiency; Young Adult | 2013 |
Differences in circulating carnitine status of preterm infants fed fortified human milk or preterm infant formula.
Topics: Carnitine; Child Development; Esterification; Female; Food, Fortified; Germany; Humans; Infant Formula; Infant Nutritional Physiological Phenomena; Infant, Low Birth Weight; Infant, Newborn; Infant, Premature; Infant, Very Low Birth Weight; Longitudinal Studies; Male; Milk, Human; Nutritional Status | 2013 |
The metabolic signature associated with the Western dietary pattern: a cross-sectional study.
Topics: Adult; Amino Acids, Branched-Chain; Cardiovascular Diseases; Carnitine; Cohort Studies; Cross-Sectional Studies; Diet; Energy Metabolism; Fatty Acids, Volatile; Feeding Behavior; Female; Health Promotion; Humans; Male; Metabolomics; Nutrition Policy; Patient Compliance; Principal Component Analysis; Quebec; Risk Factors; Up-Regulation; Urban Health | 2013 |
Dietary intake of palmitate and oleate has broad impact on systemic and tissue lipid profiles in humans.
Topics: Adolescent; Adult; Cardiovascular Diseases; Carnitine; Cohort Studies; Cross-Over Studies; Dietary Fats; Female; Humans; Intracellular Signaling Peptides and Proteins; Lipid Metabolism; Lipids; Male; Membrane Proteins; Metabolomics; Muscle, Skeletal; Oleic Acid; Palmitic Acid; Risk Factors; Sex Characteristics; Up-Regulation; Vermont; Young Adult | 2014 |
Dietary protein intake affects amino acid and acylcarnitine metabolism in infants aged 6 months.
Topics: Amino Acids; Body Weight; Breast Feeding; Carnitine; Dietary Proteins; Double-Blind Method; Female; Humans; Infant; Infant Food; Male; Obesity | 2015 |
Effects of levocarnitine on brachial-ankle pulse wave velocity in hemodialysis patients: a randomized controlled trial.
Topics: Administration, Oral; Aged; Ankle Brachial Index; Atherosclerosis; Biomarkers; Blood Flow Velocity; Carnitine; Dietary Supplements; Female; Humans; Kidney Failure, Chronic; Male; Middle Aged; Prospective Studies; Pulsatile Flow; Renal Dialysis | 2014 |
Metabolic responses of healthy or prediabetic adults to bovine whey protein and sodium caseinate do not differ.
Topics: Adult; Amino Acids; Blood Glucose; C-Peptide; Carnitine; Caseins; Dietary Carbohydrates; Female; Gastric Emptying; Gastric Inhibitory Polypeptide; Glucagon; Glucagon-Like Peptide 1; Healthy Volunteers; Humans; Insulin; Male; Milk Proteins; Postprandial Period; Prediabetic State; Single-Blind Method; Whey Proteins | 2015 |
Increased palmitate intake: higher acylcarnitine concentrations without impaired progression of β-oxidation.
Topics: Adolescent; Adult; Body Composition; Carnitine; Cytokines; Diet; Dietary Fats; Fatty Acids; Female; Humans; Immunity, Innate; Lipid Peroxidation; Male; Oleic Acid; Palmitates | 2015 |
Type 2 diabetes is associated with postprandial amino acid measures.
Topics: Adult; Amino Acids; Biomarkers; Carnitine; Diabetes Mellitus, Type 2; Female; Humans; Insulin Resistance; Male; Postprandial Period; Sleep | 2016 |
Physiological changes due to mild cooling in healthy lean males of white Caucasian and South Asian descent: A metabolomics study.
Topics: Adolescent; Adult; Asian People; Body Weight; Carnitine; Cold Temperature; Fatty Acids, Nonesterified; Glycerophospholipids; Humans; Male; Metabolomics; Sphingomyelins; Thermogenesis; White People; Young Adult | 2016 |
A single night of sleep curtailment increases plasma acylcarnitines: Novel insights in the relationship between sleep and insulin resistance.
Topics: Adult; Carnitine; Fasting; Female; Humans; Insulin Resistance; Male; Metabolomics; Sleep | 2016 |
Krill oil reduces plasma triacylglycerol level and improves related lipoprotein particle concentration, fatty acid composition and redox status in healthy young adults - a pilot study.
Topics: Adolescent; Adult; Animals; Atherosclerosis; Betaine; Carnitine; Choline; Chylomicrons; Cytokines; Dietary Fats, Unsaturated; Docosahexaenoic Acids; Eicosapentaenoic Acid; Erythrocytes; Euphausiacea; Fatty Acids, Unsaturated; Female; Humans; Lipoproteins, VLDL; Male; Methylamines; Particle Size; Pilot Projects; Triglycerides | 2015 |
Prognostic Implications of Long-Chain Acylcarnitines in Heart Failure and Reversibility With Mechanical Circulatory Support.
Topics: Aged; Carnitine; Disease Progression; Energy Metabolism; Exercise Therapy; Female; Heart Failure, Systolic; Heart-Assist Devices; Hospital Mortality; Humans; Male; Mass Spectrometry; Middle Aged; North Carolina; Outcome Assessment, Health Care; Prognosis; Reproducibility of Results; Severity of Illness Index; Statistics as Topic | 2016 |
Mortality prediction in patients with severe septic shock: a pilot study using a target metabolomics approach.
Topics: Aged; Aged, 80 and over; Amino Acids; Carnitine; Cohort Studies; Female; Glycerophospholipids; Gram-Negative Bacteria; Gram-Positive Bacteria; Humans; Intensive Care Units; Kynurenine; Male; Metabolome; Metabolomics; Middle Aged; Pilot Projects; Shock, Septic; Sphingolipids; Survival Analysis | 2016 |
Plasma acylcarnitines and risk of cardiovascular disease: effect of Mediterranean diet interventions.
Topics: Aged; Body Mass Index; Cardiovascular Diseases; Carnitine; Cohort Studies; Diet, Mediterranean; Female; Humans; Male; Middle Aged; Prospective Studies; Risk Factors; Stroke | 2016 |
Assessment of plasma acylcarnitines before and after weight loss in obese subjects.
Topics: Adult; Anthropometry; Body Composition; Carnitine; Diabetes Mellitus, Type 2; Fatty Acids; Fatty Acids, Nonesterified; Female; Glucose; Humans; Insulin Resistance; Lipolysis; Male; Middle Aged; Obesity; Oxygen; Respiration; Weight Loss; Young Adult | 2016 |
Screening of carnitine and biotin deficiencies on tandem mass spectrometry.
Topics: Adolescent; Biomarkers; Biotin; Carnitine; Child; Child, Preschool; Dried Blood Spot Testing; Female; Humans; Infant; Male; Mass Screening; Nutritional Status; Prospective Studies; Tandem Mass Spectrometry | 2017 |
Reduction in cardiometabolic risk factors by a multifunctional diet is mediated via several branches of metabolism as evidenced by nontargeted metabolite profiling approach.
Topics: Aged; Cardiovascular Diseases; Carnitine; Cholesterol, LDL; Diet; Fasting; Fatty Acids; Female; Humans; Lipids; Male; Metabolomics; Middle Aged; Overweight; Risk Factors; Triglycerides | 2017 |
Effects of weight loss using supplementation with Lactobacillus strains on body fat and medium-chain acylcarnitines in overweight individuals.
Topics: Adipose Tissue; Carnitine; Dietary Supplements; Double-Blind Method; Humans; Lactobacillus; Lactobacillus plantarum; Overweight; Probiotics; Triglycerides; Weight Loss | 2017 |
A discovery-driven approach to elucidate urinary metabolome changes after a regular and moderate consumption of beer and nonalcoholic beer in subjects at high cardiovascular risk.
Topics: 3-Hydroxyacyl CoA Dehydrogenases; Acetyl-CoA C-Acyltransferase; Adipates; Aged; Alcohol Drinking; Beer; Beverages; Biomarkers; Carbon-Carbon Double Bond Isomerases; Cardiovascular Diseases; Carnitine; Creatinine; Cross-Over Studies; Diet; Enoyl-CoA Hydratase; Exercise; Humans; Male; Metabolome; Metabolomics; Middle Aged; Patient Compliance; Pentanoic Acids; Racemases and Epimerases; Risk Factors; Xanthones | 2017 |
Treatment of Swedish Patients with Graves' Hyperthyroidism Is Associated with Changes in Acylcarnitine Levels.
Topics: Adult; Antithyroid Agents; Carnitine; Combined Modality Therapy; Fatty Acids; Fatty Acids, Volatile; Female; Follow-Up Studies; Graves Disease; Hormone Replacement Therapy; Humans; Male; Metabolomics; Methimazole; Middle Aged; Molecular Weight; Principal Component Analysis; Sweden; Thyroid Gland; Thyroxine | 2017 |
Military training elicits marked increases in plasma metabolomic signatures of energy metabolism, lipolysis, fatty acid oxidation, and ketogenesis.
Topics: Carnitine; Diglycerides; Energy Metabolism; Fatty Acids; Humans; Lipolysis; Male; Metabolome; Military Personnel; Physical Conditioning, Human; Skiing; Young Adult | 2017 |
Plasma Palmitoyl-Carnitine (AC16:0) Is a Marker of Increased Postprandial Nonesterified Incomplete Fatty Acid Oxidation Rate in Adults With Type 2 Diabetes.
Topics: Adult; Biomarkers; Carnitine; Diabetes Mellitus, Type 2; Fasting; Fatty Acids, Nonesterified; Female; Humans; Insulin Resistance; Lipid Metabolism; Male; Middle Aged; Oxidation-Reduction; Palmitoylcarnitine; Postprandial Period; Young Adult | 2018 |
Basal insulin peglispro increases lipid oxidation, metabolic flexibility, thermogenesis and ketone bodies compared to insulin glargine in subjects with type 1 diabetes mellitus.
Topics: Adult; Basal Metabolism; Biomarkers; Breakfast; Carnitine; Cross-Over Studies; Diabetes Mellitus, Type 1; Drug Administration Schedule; Drug Monitoring; Female; Follow-Up Studies; Glycolysis; Humans; Hypoglycemic Agents; Insulin Glargine; Insulin Lispro; Ketone Bodies; Lipolysis; Male; Middle Aged; Oxidation-Reduction; Polyethylene Glycols; Thermogenesis; Young Adult | 2018 |
Plasma fatty acyl-carnitines during 8 weeks of overfeeding: relation to diet energy expenditure and body composition: the PROOF study.
Topics: Adolescent; Adult; Body Composition; Carnitine; Diet; Energy Intake; Energy Metabolism; Fatty Acids; Female; Humans; Hyperphagia; Male; Young Adult | 2018 |
Family history and obesity in youth, their effect on acylcarnitine/aminoacids metabolomics and non-alcoholic fatty liver disease (NAFLD). Structural equation modeling approach.
Topics: Adolescent; Adult; Amino Acids; Carnitine; Cross-Sectional Studies; Diabetes Mellitus, Type 2; Female; Humans; Male; Medical History Taking; Metabolomics; Middle Aged; Models, Biological; Non-alcoholic Fatty Liver Disease; Obesity | 2018 |
Metabolic perturbations associated with the consumption of a ketogenic medium-chain TAG diet in dogs with idiopathic epilepsy.
Topics: Animals; Anticonvulsants; Carnitine; Chromatography, Liquid; Cross-Over Studies; Diet; Diet, Ketogenic; Dog Diseases; Dogs; Epilepsy; Fasting; Fatty Acids; Female; Lipid Metabolism; Lipids; Male; Mass Spectrometry; Metabolome; Phosphatidylcholines; Placebos; Triglycerides | 2018 |
GS-0976 Reduces Hepatic Steatosis and Fibrosis Markers in Patients With Nonalcoholic Fatty Liver Disease.
Topics: Acetyl-CoA Carboxylase; Biomarkers; Carnitine; Double-Blind Method; Elasticity Imaging Techniques; Fatty Liver; Female; Humans; Isobutyrates; Liver Cirrhosis; Magnetic Resonance Imaging; Male; Middle Aged; Non-alcoholic Fatty Liver Disease; Oxazoles; Pyrimidines | 2018 |
The Association of Acylcarnitines and Amino Acids With Age in Dutch and South-Asian Surinamese Living in Amsterdam.
Topics: Adolescent; Adult; Age Factors; Aged; Amino Acids; Asian People; Biomarkers; Carnitine; Cohort Studies; Cross-Sectional Studies; Ethnicity; Female; Follow-Up Studies; Humans; Male; Metabolic Diseases; Middle Aged; Netherlands; Prevalence; Prognosis; Suriname; White People; Young Adult | 2018 |
Plasma metabolomic profiling of a ketamine and placebo crossover trial of major depressive disorder and healthy control subjects.
Topics: Adult; Amino Acids, Essential; Antidepressive Agents; Biogenic Amines; Carnitine; Cross-Over Studies; Depressive Disorder, Major; Depressive Disorder, Treatment-Resistant; Double-Blind Method; Female; Glycerophospholipids; Humans; Ketamine; Lipids; Male; Metabolomics; Middle Aged; Sphingolipids; Young Adult | 2018 |
Changes in Plasma Acylcarnitine and Lysophosphatidylcholine Levels Following a High-Fructose Diet: A Targeted Metabolomics Study in Healthy Women.
Topics: Adult; Biomarkers; Carnitine; Cross-Over Studies; Diet, Carbohydrate-Restricted; Dietary Sugars; Female; Fruit; Germany; High Fructose Corn Syrup; Humans; Lipid Peroxidation; Lysophosphatidylcholines; Metabolomics; Mitochondria; Obesity; Oxidation-Reduction; Time Factors; Vegetables; Young Adult | 2018 |
Metabolomics identifies increases in the acylcarnitine profiles in the plasma of overweight subjects in response to mild weight loss: a randomized, controlled design study.
Topics: Adult; Caloric Restriction; Carnitine; Fatty Acids, Nonesterified; Female; Humans; Intra-Abdominal Fat; Male; Metabolomics; Middle Aged; Overweight; Weight Loss | 2018 |
An Integrated Understanding of the Molecular Mechanisms of How Adipose Tissue Metabolism Affects Long-term Body Weight Maintenance.
Topics: Adipose Tissue; Adolescent; Body Weight; Body Weight Maintenance; Carnitine; Child; Female; Humans; Male; Weight Loss | 2019 |
Nutritional ketosis improves exercise metabolism in patients with very long-chain acyl-CoA dehydrogenase deficiency.
Topics: Adolescent; Adult; Beverages; Blood Glucose; Carnitine; Congenital Bone Marrow Failure Syndromes; Cross-Over Studies; Diet, Ketogenic; Endurance Training; Esters; Exercise Test; Female; Humans; Ketones; Ketosis; Lipid Metabolism, Inborn Errors; Magnetic Resonance Spectroscopy; Male; Middle Aged; Mitochondrial Diseases; Muscle, Skeletal; Muscular Diseases; Netherlands; Pulmonary Gas Exchange; Young Adult | 2020 |
Alterations of the acylcarnitine profiles in blood serum and in muscle from periparturient cows with normal or elevated body condition.
Topics: Animals; Carnitine; Carnitine O-Palmitoyltransferase; Cattle; Diet; Fatty Acids; Female; Lactation; Muscles; Parturition; Pregnancy | 2020 |
Altered Plasma Acylcarnitines and Amino Acids Profile in Spinocerebellar Ataxia Type 7.
Topics: Adult; Amino Acids; Biomarkers; Carnitine; Female; Humans; Male; Middle Aged; Spinocerebellar Ataxias | 2020 |
Metabolome and microbiome alterations related to short-term feeding of a micronutrient-fortified, high-quality legume protein-based food product to stunted school age children: A randomized controlled pilot trial.
Topics: Amino Acids; Anthropometry; Carnitine; Child; Diet, High-Protein; Eating; Fabaceae; Feces; Female; Food, Fortified; Gastrointestinal Microbiome; Growth Disorders; Humans; Male; Metabolome; Micronutrients; Pilot Projects; Treatment Outcome | 2020 |
A metabolomic study of red and processed meat intake and acylcarnitine concentrations in human urine and blood.
Topics: Adult; Animals; Carnitine; Cross-Sectional Studies; Female; Humans; Male; Meat Products; Metabolomics; Prospective Studies; Swine | 2020 |
L-carnitine infusion does not alleviate lipid-induced insulin resistance and metabolic inflexibility.
Topics: Adult; Carnitine; Cross-Over Studies; Emulsions; Fatty Acids, Nonesterified; Humans; Infusion Pumps; Insulin; Insulin Resistance; Lipids; Male; Muscle, Skeletal; Phospholipids; Soybean Oil; Young Adult | 2020 |
Different Blood Metabolomics Profiles in Infants Consuming a Meat- or Dairy-Based Complementary Diet.
Topics: Amino Acids, Branched-Chain; Amino Acids, Essential; Carnitine; Dairy Products; Diet; Follow-Up Studies; Humans; Infant; Infant Nutritional Physiological Phenomena; Isoleucine; Leucine; Meat; Metabolomics; Phenylalanine; Valine | 2021 |
Plasma acylcarnitines and risk of lower-extremity functional impairment in older adults: a nested case-control study.
Topics: Aged; Body Mass Index; Carnitine; Energy Intake; Female; Humans; Lower Extremity; Male; Middle Aged | 2021 |
Metabolite profiles associated with disease progression in influenza infection.
Topics: Adult; Carnitine; Case-Control Studies; Disease Progression; Female; Glycerides; Humans; Influenza A Virus, H1N1 Subtype; Influenza, Human; Male; Metabolome; Middle Aged; Sphingolipids | 2021 |
Urinary Medium-Chained Acyl-Carnitines Sign High Caloric Intake whereas Short-Chained Acyl-Carnitines Sign High -Protein Diet within a High-Fat, Hypercaloric Diet in a Randomized Crossover Design Dietary Trial.
Topics: Adult; Biomarkers; Carnitine; Cross-Over Studies; Diet, High-Fat; Diet, High-Protein; Diet, Western; Dietary Fats; Dietary Proteins; Energy Intake; Female; Glucose; Healthy Volunteers; Humans; Lipid Metabolism; Liver; Male; Metabolic Syndrome; Postprandial Period; Renal Elimination; Young Adult | 2021 |
Effects of gut microbiota and fatty acid metabolism on dyslipidemia following weight-loss diets in women: Results from a randomized controlled trial.
Topics: Adult; Caloric Restriction; Carnitine; Diet, Carbohydrate-Restricted; Diet, Reducing; Dyslipidemias; Erythrocytes; Fatty Acids; Feces; Female; Gastrointestinal Microbiome; Humans; Lipid Metabolism; Middle Aged; Obesity; Overweight; Treatment Outcome; Weight Loss | 2021 |
Plasma acylcarnitines and risk of incident heart failure and atrial fibrillation: the Prevención con dieta mediterránea study.
Topics: Atrial Fibrillation; Cardiovascular Diseases; Carnitine; Diabetes Mellitus, Type 2; Diet, Mediterranean; Heart Failure; Humans; Mediterranea; Nuts; Obesity; Olive Oil; Risk Factors | 2022 |
Gut microbiota and acylcarnitine metabolites connect the beneficial association between equol and adiposity in adults: a prospective cohort study.
Topics: Adiposity; Adult; Carnitine; Equol; Female; Gastrointestinal Microbiome; Humans; Isoflavones; Male; Middle Aged; Obesity; Prospective Studies | 2022 |
S-adenosyl methionine (SAMe) versus escitalopram and placebo in major depression RCT: efficacy and effects of histamine and carnitine as moderators of response.
Topics: Adult; Antidepressive Agents; Biomarkers; Carnitine; Citalopram; Depressive Disorder, Major; Double-Blind Method; Female; Histamine; Humans; Male; Middle Aged; S-Adenosylmethionine; Selective Serotonin Reuptake Inhibitors; Treatment Outcome | 2014 |
977 other study(ies) available for carnitine and s-adenosylmethionine
| Article | Year |
|---|---|
Studies on the oxidation of phytanic acid and pristanic acid in human fibroblasts by acylcarnitine analysis.
Topics: Carnitine; Cells, Cultured; Fatty Acids; Fibroblasts; Humans; Oxidation-Reduction; Peroxisomal Disorders; Phytanic Acid | 1998 |
Low levels of serum acylcarnitine in chronic fatigue syndrome and chronic hepatitis type C, but not seen in other diseases.
Topics: Acute Disease; Animals; Carnitine; Chemical and Drug Induced Liver Injury; Diabetes Mellitus; Fatigue Syndrome, Chronic; Female; Galactosamine; Hepatitis C, Chronic; Humans; Japan; Male; Mice; Mice, Inbred C3H; Neoplasms; Sweden | 1998 |
Short-chain acyl-CoA dehydrogenase deficiency: a cause of ophthalmoplegia and multicore myopathy.
Topics: Acyl-CoA Dehydrogenase; Acyl-CoA Dehydrogenases; Adolescent; Carnitine; Cells, Cultured; Diagnosis, Differential; Female; Fibroblasts; Humans; Mitochondrial Myopathies; Ophthalmoplegia, Chronic Progressive External; Phenotype | 1999 |
Cardiomegaly in the juvenile visceral steatosis (JVS) mouse is reduced with acute elevation of heart short-chain acyl-carnitine level after L-carnitine injection.
Topics: Aging; Animals; Body Weight; Cardiomegaly; Carnitine; Disease Models, Animal; Half-Life; Injections, Intraperitoneal; Lipid Metabolism; Mice; Mice, Inbred Strains; Myocardium; Organ Size; Time Factors | 1999 |
Carnitine homeostasis in patients with rheumatoid arthritis.
Topics: Adult; Aged; Arthritis, Rheumatoid; Biomechanical Phenomena; Carnitine; Female; Homeostasis; Humans; Kidney; Male; Middle Aged; Muscle, Skeletal | 1999 |
Identification of new medium-chain acylcarnitines present in urine of a patient with medium-chain acyl-CoA dehydrogenase deficiency.
Topics: Acyl-CoA Dehydrogenase; Acyl-CoA Dehydrogenases; Carnitine; Child, Preschool; Female; Glucuronates; Glycine; Humans | 1999 |
Normal acylcarnitines in maternal urine during a pregnancy affected by glutaric aciduria type II.
Topics: Acidosis, Renal Tubular; Carnitine; Female; Glutarates; Humans; Infant, Newborn; Male; Pregnancy | 1999 |
Evaluation of carnitine nutritional status in full-term newborn infants.
Topics: Carnitine; Dietary Supplements; Humans; Infant Food; Infant, Newborn; Nutritional Status; Reference Values | 1998 |
Quantitative acylcarnitine profiling in fibroblasts using [U-13C] palmitic acid: an improved tool for the diagnosis of fatty acid oxidation defects.
Topics: Carbon Isotopes; Carnitine; Cells, Cultured; Fatty Acids; Fibroblasts; Gas Chromatography-Mass Spectrometry; Humans; Lipid Metabolism, Inborn Errors; Oxidation-Reduction; Palmitic Acid; Spectrometry, Mass, Fast Atom Bombardment | 1999 |
Influence of acetate and bicarbonate dialysate on blood short- and long-chain acyl carnitine in adult pyelonephritis patients.
Topics: Acetates; Adult; Bicarbonates; Carnitine; Chronic Disease; Erythrocytes; Female; Humans; Male; Pyelonephritis; Renal Dialysis | 1999 |
Carnitine-acylcarnitine translocase deficiency is a treatable disease.
Topics: Acetylcarnitine; Carnitine; Carnitine Acyltransferases; Female; Humans; Infant, Newborn; Lipid Metabolism, Inborn Errors; Palmitoylcarnitine; Treatment Outcome | 1999 |
Quantitative plasma acylcarnitine analysis using electrospray tandem mass spectrometry for the diagnosis of organic acidaemias and fatty acid oxidation defects.
Topics: Carnitine; Child; Child, Preschool; Fatty Acids; Humans; Infant; Lipid Metabolism, Inborn Errors; Mass Spectrometry; Oxidation-Reduction | 1999 |
Diagnosis of mitochondrial trifunctional protein deficiency in a blood spot from the newborn screening card by tandem mass spectrometry and DNA analysis.
Topics: 3-Hydroxyacyl CoA Dehydrogenases; Base Sequence; Cardiomyopathies; Carnitine; DNA; Female; Genetic Testing; Heterozygote; Humans; Infant, Newborn; Long-Chain-3-Hydroxyacyl-CoA Dehydrogenase; Male; Mass Spectrometry; Mitochondrial Trifunctional Protein; Multienzyme Complexes; Mutation, Missense; Neonatal Screening; Nuclear Family; Reye Syndrome; Sequence Deletion | 1999 |
Very long chain acyl coenzyme A dehydrogenase deficiency in a 5-month-old Korean boy: identification of a novel mutation.
Topics: Acyl-CoA Dehydrogenase, Long-Chain; Arginine; Cardiomyopathies; Carnitine; Codon, Terminator; Fatal Outcome; Fatty Acid Desaturases; Genetic Heterogeneity; Humans; Infant; Korea; Lipid Metabolism, Inborn Errors; Male; Mutation | 1999 |
Noninvasive evaluation of adult onset myopathy from carnitine palmitoyl transferase II deficiency using proton magnetic resonance spectroscopy.
Topics: Adult; Age of Onset; Biomarkers; Carnitine; Carnitine O-Palmitoyltransferase; Fatigue; Female; Humans; Magnetic Resonance Spectroscopy; Muscles; Muscular Diseases; Myoglobinuria | 1999 |
Effects of pentanoate, 4-pentenoate, 3-hydroxybutyrate and insulin on the tissue-levels of long-chain acyl CoA and acylcarnitine in the oxygenated and hypoxic rat atria.
Topics: 3-Hydroxybutyric Acid; Acyl Coenzyme A; Aerobiosis; Animals; Carnitine; Cell Hypoxia; Fatty Acids, Monounsaturated; Female; Heart Atria; Insulin; Male; Oxidative Stress; Oxygen; Pentanoic Acids; Rats; Rats, Wistar | 1999 |
Carnitine transport and its inhibition by sulfonylureas in human kidney proximal tubular epithelial cells.
Topics: Administration, Oral; Animals; Biological Transport; Carnitine; Cell Line; Cell Membrane; Epithelial Cells; Humans; Hypoglycemic Agents; Kidney Tubules, Proximal; Microvilli; Rats; Sulfonylurea Compounds | 1999 |
Serum carnitine concentrations in patients with idiopathic hypertrophic cardiomyopathy: relationship with impaired myocardial fatty acid metabolism.
Topics: Adolescent; Adult; Aged; Biomarkers; Cardiomyopathy, Hypertrophic; Carnitine; Fatty Acids; Fatty Acids, Nonesterified; Female; Humans; Iodobenzenes; Male; Middle Aged; Myocardium; Radionuclide Imaging; Ultrasonography | 1999 |
Effect of sports activity on carnitine metabolism. Measurement of free carnitine, gamma-butyrobetaine and acylcarnitines by tandem mass spectrometry.
Topics: Betaine; Carnitine; Exercise; Humans; Mass Spectrometry | 1999 |
Acylcarnitine analogues as topical, microbicidal spermicides.
Topics: Anti-Infective Agents; Candida albicans; Carnitine; HIV-1; Microbial Sensitivity Tests; Spermatocidal Agents | 1999 |
Dynamic changes of plasma acylcarnitine levels induced by fasting and sunflower oil challenge test in children.
Topics: 3-Hydroxybutyric Acid; Acetoacetates; Blood Glucose; Carnitine; Child; Child, Preschool; Dietary Fats, Unsaturated; Fasting; Fatty Acids, Nonesterified; Humans; Infant; Ketone Bodies; Molecular Structure; Plant Oils; Sunflower Oil | 1999 |
Identification of two novel mutations in the hypoglycemic phenotype of very long chain acyl-CoA dehydrogenase deficiency.
Topics: Acyl-CoA Dehydrogenase, Long-Chain; Alleles; Carnitine; Child, Preschool; DNA, Complementary; Exons; Female; Fibroblasts; Humans; Hypoglycemia; Mitochondria; Mutation; Palmitoylcarnitine; Phenotype | 1999 |
Direct chromatographic resolution of carnitine and O-acylcarnitine enantiomers on a teicoplanin-bonded chiral stationary phase.
Topics: Carnitine; Chromatography, High Pressure Liquid; Humans; Spectrophotometry, Ultraviolet; Stereoisomerism; Teicoplanin | 1999 |
Arrhythmias and conduction defects as presenting symptoms of fatty acid oxidation disorders in children.
Topics: 3-Hydroxyacyl CoA Dehydrogenases; Acyl-CoA Dehydrogenase; Acyl-CoA Dehydrogenase, Long-Chain; Arrhythmias, Cardiac; Carnitine; Carnitine Acyltransferases; Carnitine O-Palmitoyltransferase; Fatty Acid Desaturases; Fatty Acids; Female; Heart Conduction System; Humans; Infant; Infant, Newborn; Long-Chain-3-Hydroxyacyl-CoA Dehydrogenase; Male; Mitochondria, Heart; Mitochondrial Myopathies; Models, Biological; Oxidation-Reduction; Sudden Infant Death; Tachycardia, Ventricular | 1999 |
Influence of acetate and bicarbonate dialysate on acyl carnitine in pyelonephritis.
Topics: Acetates; Bicarbonates; Carnitine; Humans; Pyelonephritis; Renal Dialysis | 1999 |
Automated tandem mass spectrometry for mass newborn screening for disorders in fatty acid, organic acid, and amino acid metabolism.
Topics: Amino Acids; Biomarkers; Carnitine; Humans; Infant, Newborn; Mass Screening; Mass Spectrometry; Metabolism, Inborn Errors; Prospective Studies | 1999 |
Identification of the mitochondrial carnitine carrier in Saccharomyces cerevisiae.
Topics: Acetylcarnitine; Amino Acid Transport Systems; Carnitine; Carrier Proteins; Chromatography, Affinity; Kinetics; Mitochondria; Mitochondrial Proteins; Molecular Sequence Data; Recombinant Proteins; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Substrate Specificity; Time Factors | 1999 |
Newborn screening with tandem mass spectrometry: 12 months' experience in NSW Australia.
Topics: Amino Acid Metabolism, Inborn Errors; Carnitine; Female; Humans; Infant, Newborn; Male; Mass Spectrometry; Neonatal Screening; Pilot Projects; Program Evaluation; Sensitivity and Specificity; South Australia; Western Australia | 1999 |
Evidence for a short-chain carnitine-acylcarnitine translocase in mitochondria specifically related to the metabolism of branched-chain amino acids.
Topics: Amino Acids, Branched-Chain; Biological Transport; Carnitine; Carnitine Acyltransferases; Cells, Cultured; Child; Deuterium; Fibroblasts; Humans; Intracellular Membranes; Isoleucine; Mass Spectrometry; Metabolism, Inborn Errors; Mitochondria; Oxidation-Reduction | 2000 |
Determination of carnitine and acylcarnitines in biological samples by capillary electrophoresis-mass spectrometry.
Topics: Carnitine; Electrophoresis, Capillary; Humans; Mass Spectrometry; Reproducibility of Results; Sensitivity and Specificity | 1999 |
Acylcarnitines in fibroblasts of patients with long-chain 3-hydroxyacyl-CoA dehydrogenase deficiency and other fatty acid oxidation disorders.
Topics: 3-Hydroxyacyl CoA Dehydrogenases; Carnitine; Cells, Cultured; Fatty Acids; Fibroblasts; Humans; Microbodies; Oxidation-Reduction | 2000 |
Production and export of acylcarnitine esters by neonatal rat hepatocytes.
Topics: Animals; Animals, Newborn; Carbon Radioisotopes; Carnitine; Cells, Cultured; Liver; Palmitic Acid; Rats | 1999 |
Rapid diagnosis of organic acidemias and fatty-acid oxidation defects by quantitative electrospray tandem-MS acyl-carnitine analysis in plasma.
Topics: Acyl-CoA Dehydrogenases; Biomarkers; Calibration; Carnitine; Carnitine O-Palmitoyltransferase; Humans; Lipid Metabolism, Inborn Errors; Oxidation-Reduction; Sensitivity and Specificity; Spectrometry, Mass, Secondary Ion | 1999 |
MCAD deficiency. Acylcarnitines (AC) by tandem mass spectrometry (MS-MS) are useful to monitor dietary treatment.
Topics: Acyl-CoA Dehydrogenase; Carnitine; Fatty Acid Desaturases; Female; Humans; Infant; Lipid Metabolism, Inborn Errors; Mass Spectrometry; Monitoring, Physiologic | 1999 |
Determination of urinary acylcarnitines: a complementary aid for the high-risk screening of several organic acidurias using a simple and reliable GC/MS-based method.
Topics: Carboxylic Acids; Carnitine; Gas Chromatography-Mass Spectrometry; Humans; Mass Screening; Mass Spectrometry; Metabolism, Inborn Errors; Reproducibility of Results; Spectrometry, Mass, Fast Atom Bombardment | 2000 |
Identification of undescribed medium-chain acylcarnitines present in urine of patients with propionic and methylmalonic acidemias.
Topics: Adult; Carboxy-Lyases; Carnitine; Case-Control Studies; Gas Chromatography-Mass Spectrometry; Humans; Infant; Lipid Metabolism, Inborn Errors; Male; Methylmalonic Acid; Methylmalonyl-CoA Decarboxylase; Propionates; Spectrometry, Mass, Fast Atom Bombardment | 2000 |
Glutaric aciduria type II: observations in seven patients with neonatal- and late-onset disease.
Topics: Acidosis; Age of Onset; Brain; Carnitine; Child; Consanguinity; Female; Glutarates; Humans; Infant; Infant, Newborn; Magnetic Resonance Imaging; Male; Mass Spectrometry; Metabolism, Inborn Errors; Tomography, Emission-Computed | 2000 |
Very-long-chain acyl-coenzyme A dehydrogenase (VLCAD) deficiency: monitoring of treatment by carnitine/acylcarnitine analysis in blood spots.
Topics: Carnitine; Fatty Acid Desaturases; Humans; Infant; Lipid Metabolism, Inborn Errors; Male; Monitoring, Physiologic; Sequence Analysis, DNA | 2000 |
2-Methylbutyryl-coenzyme A dehydrogenase deficiency: a new inborn error of L-isoleucine metabolism.
Topics: Amino Acid Metabolism, Inborn Errors; Base Sequence; Carnitine; DNA Primers; DNA, Complementary; Female; Humans; Infant; Isoleucine; Male; Oxidoreductases; Oxidoreductases Acting on CH-CH Group Donors; Pregnancy; Prenatal Diagnosis | 2000 |
Metabolism of carnitine in phenylacetic acid-treated rats and in patients with phenylketonuria.
Topics: Adult; Animals; Betaine; Carnitine; Female; Glutamic Acid; Homogentisic Acid; Humans; Ketoglutaric Acids; Liver; Male; Mass Spectrometry; Phenylacetates; Phenylketonurias; Phenylpyruvic Acids; Rats; Rats, Wistar | 2000 |
Normal carnitine levels in patients with chronic fatigue syndrome.
Topics: Adult; Carnitine; Case-Control Studies; Fatigue; Fatigue Syndrome, Chronic; Female; Humans; Middle Aged; Netherlands; Registries; Severity of Illness Index; Single-Blind Method; Statistics, Nonparametric | 2000 |
Carnitine-acylcarnitine translocase deficiency: metabolic consequences of an impaired mitochondrial carnitine cycle.
Topics: Ammonia; Cardiac Output, Low; Carnitine; Carnitine Acyltransferases; Cells, Cultured; Coma; Consanguinity; Dicarboxylic Acids; Fatal Outcome; Female; Fibroblasts; Humans; Hypoglycemia; Infant, Newborn; Lactic Acid; Mass Spectrometry; Mitochondria; Pregnancy; Seizures; Uric Acid | 2000 |
The biochemical metabolite screen in the Munich ENU Mouse Mutagenesis Project: determination of amino acids and acylcarnitines by tandem mass spectrometry.
Topics: Amino Acids; Animals; Biomarkers; Carnitine; Ethylnitrosourea; Mass Spectrometry; Mice; Mutagenesis; Mutagens | 2000 |
Long-chain acylcarnitine induces Ca2+ efflux from the sarcoplasmic reticulum.
Topics: Animals; Calcium; Calcium Channels; Calcium-Transporting ATPases; Carnitine; Myocardium; Palmitoylcarnitine; Rabbits; Ryanodine Receptor Calcium Release Channel; Sarcoplasmic Reticulum | 2000 |
Evaluation of brain long-chain acylcarnitines during cerebral ischemia.
Topics: Animals; Brain; Brain Ischemia; Carnitine; Male; Rats; Spectrometry, Mass, Electrospray Ionization | 2000 |
Elucidation of the mechanism by which (+)-acylcarnitines inhibit mitochondrial fatty acid transport.
Topics: Animals; Biological Transport, Active; Carnitine; Carnitine Acyltransferases; Carnitine O-Palmitoyltransferase; Cells, Cultured; Fatty Acids; Male; Mitochondria, Liver; Rats; Rats, Sprague-Dawley | 2000 |
Kinetics of carnitine palmitoyltransferase-I are altered by dietary variables and suggest a metabolic need for supplemental carnitine in young pigs.
Topics: Animals; Carnitine; Carnitine O-Palmitoyltransferase; Diet; Dietary Supplements; Glycine max; Kinetics; Liver; Mitochondria; Mitochondria, Liver; Muscle, Skeletal; Soybean Oil; Swine; Zea mays | 2000 |
Acylcarnitines in plasma and blood spots of patients with long-chain 3-hydroxyacyl-coenzyme A dehydrogenase defiency.
Topics: 3-Hydroxyacyl CoA Dehydrogenases; Carnitine; Erythrocytes; False Negative Reactions; Female; Genotype; Heterozygote; Homozygote; Humans; Male; Mutation; Plasma; Sensitivity and Specificity | 2000 |
Myocardial carnitine and carnitine palmitoyltransferase deficiencies in patients with severe heart failure.
Topics: Biopsy; Carnitine; Carnitine O-Palmitoyltransferase; Female; Heart Failure; Heart Transplantation; Humans; Male; Middle Aged; Myocardium; Stroke Volume | 2000 |
Analysis of carnitine and acylcarnitines in urine by capillary electrophoresis.
Topics: Carnitine; Electrophoresis, Capillary; Humans; Methylhydrazines; Reference Standards | 2000 |
Postnatal changes in neonatal acylcarnitine profile.
Topics: Carnitine; Fatty Acids; Humans; Infant, Newborn; Mass Spectrometry; Reference Standards | 2001 |
The interaction of ferrocytochrome c with long-chain fatty acids and their CoA and carnitine esters.
Topics: Acyl Coenzyme A; Animals; Carnitine; Cytochrome c Group; Fatty Acids; Fatty Alcohols; Horses; Ligands; Nuclear Magnetic Resonance, Biomolecular; Oleic Acid; Palmitoylcarnitine; Spectrum Analysis | 2000 |
Carnitine palmitoyltransferase I deficiency in neonate identified by dried blood spot free carnitine and acylcarnitine profile.
Topics: Carnitine; Carnitine O-Palmitoyltransferase; Fibroblasts; Humans; Infant, Newborn; Male; Oxidation-Reduction | 2001 |
Carnitine transporter defect diagnosed by newborn screening with electrospray tandem mass spectrometry.
Topics: Birth Weight; Carnitine; Carrier Proteins; Humans; Infant, Newborn; Male; Neonatal Screening; Organic Cation Transport Proteins; Solute Carrier Family 22 Member 5; Spectrometry, Mass, Electrospray Ionization | 2001 |
Pig liver carnitine palmitoyltransferase I, with low Km for carnitine and high sensitivity to malonyl-CoA inhibition, is a natural chimera of rat liver and muscle enzymes.
Topics: Amino Acid Sequence; Animals; Base Sequence; Carnitine; Carnitine O-Palmitoyltransferase; Cloning, Molecular; DNA, Complementary; Enzyme Inhibitors; Humans; Isoenzymes; Kinetics; Malonyl Coenzyme A; Mice; Mitochondria, Liver; Mitochondria, Muscle; Molecular Sequence Data; Organ Specificity; Pichia; Rats; Sequence Alignment; Swine | 2001 |
Medium-chain acyl-CoA dehydrogenase (MCAD) mutations identified by MS/MS-based prospective screening of newborns differ from those observed in patients with clinical symptoms: identification and characterization of a new, prevalent mutation that results i
Topics: Acyl-CoA Dehydrogenase; Acyl-CoA Dehydrogenases; Alleles; Carnitine; Chaperonin 10; Chaperonin 60; DNA Mutational Analysis; Enzyme Stability; Escherichia coli; Exons; Genetic Testing; Haplotypes; Heterozygote; Homozygote; Humans; Infant, Newborn; Mass Spectrometry; Molecular Sequence Data; Mutagenesis, Site-Directed; Mutation, Missense; Polymorphism, Single Nucleotide; Protein Folding; Recombinant Proteins; Reproducibility of Results; Temperature | 2001 |
Impact of the intramitochondrial enzyme organization on fatty acid oxidation.
Topics: Acyl-CoA Dehydrogenase; Acyl-CoA Dehydrogenase, Long-Chain; Animals; Carnitine; Fatty Acids; Fatty Acids, Volatile; Membrane Proteins; Mitochondria; Oxidation-Reduction; Oxidoreductases; Rats; Substrate Specificity | 2001 |
Design of a pilot study to evaluate tandem mass spectrometry for neonatal screening.
Topics: Amino Acids; Carnitine; Humans; Infant, Newborn; Mass Spectrometry; Metabolism, Inborn Errors; Neonatal Screening; Pilot Projects | 1999 |
Molecular and functional characterisation of mild MCAD deficiency.
Topics: Acyl-CoA Dehydrogenase; Acyl-CoA Dehydrogenases; Carnitine; Consanguinity; DNA Mutational Analysis; Female; Fibroblasts; Genetic Variation; Germany; Heterozygote; Homozygote; Humans; Infant; Lymphocytes; Male; Mutation; Mutation, Missense; Phenylpropionates; Protein Processing, Post-Translational; Turkey | 2001 |
Multiple acyl-CoA-dehydrogenase deficiency (MADD): use of acylcarnitines and fatty acids to monitor the response to dietary treatment.
Topics: Acyl-CoA Dehydrogenase; Acyl-CoA Dehydrogenases; Amino Acid Metabolism, Inborn Errors; Carnitine; Diet; Fatty Acids; Female; Humans; Infant, Newborn; Lipid Metabolism, Inborn Errors; Neonatal Screening | 2001 |
Electrospray tandem mass spectrometry for analysis of acylcarnitines in dried postmortem blood specimens collected at autopsy from infants with unexplained cause of death.
Topics: Autopsy; Bile; Blood Specimen Collection; Canada; Carnitine; Fatty Acids; Humans; Infant; Infant, Newborn; Metabolism, Inborn Errors; Oxidation-Reduction; Paper; Reference Values; Spectrometry, Mass, Electrospray Ionization; Sudden Infant Death; United States | 2001 |
Protection of ischemic hearts perfused with an anion exchange inhibitor, DIDS, is associated with beneficial changes in substrate metabolism.
Topics: 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid; Adenosine Triphosphate; Animals; Anion Exchange Protein 1, Erythrocyte; Carnitine; Fatty Acids; Glucose; Myocardial Ischemia; Myocardial Reperfusion; Myocardium; Oxidation-Reduction; Perfusion; Phosphocreatine; Phospholipids; Rats; Triglycerides | 2001 |
Hyperinsulinism in short-chain L-3-hydroxyacyl-CoA dehydrogenase deficiency reveals the importance of beta-oxidation in insulin secretion.
Topics: 3-Hydroxyacyl CoA Dehydrogenases; Amino Acid Sequence; Animals; Base Sequence; Carnitine; DNA Primers; Evolution, Molecular; Fatty Acids; Female; Gene Expression; Homozygote; Humans; Hyperinsulinism; Hypoglycemia; In Vitro Techniques; Infant; Insulin; Insulin Secretion; Models, Biological; Molecular Sequence Data; Oxidation-Reduction; Point Mutation; Recombinant Proteins; Sequence Homology, Amino Acid | 2001 |
A rapid and quantitative mass spectrometry method for determining the concentration of acylcarnitines and aminoacids in amniotic fluid.
Topics: Amino Acids; Amniotic Fluid; Carnitine; Female; Fetal Diseases; Humans; Mass Spectrometry; Metabolic Diseases; Predictive Value of Tests; Pregnancy; Prenatal Diagnosis; Sensitivity and Specificity | 2001 |
Valproate induces in vitro accumulation of long-chain fatty acylcarnitines.
Topics: Carnitine; Cell Line; Fatty Acids; Fibroblasts; Gas Chromatography-Mass Spectrometry; Humans; Mitochondria; Mitochondrial Trifunctional Protein; Multienzyme Complexes; Palmitic Acid; Valproic Acid | 2001 |
Evaluation of newborn screening for medium chain acyl-CoA dehydrogenase deficiency in 275 000 babies.
Topics: Acyl-CoA Dehydrogenase; Acyl-CoA Dehydrogenases; Australian Capital Territory; Carnitine; Humans; Infant, Newborn; Mass Spectrometry; Mutation; Neonatal Screening; New South Wales; Prospective Studies; Retrospective Studies | 2001 |
Hepatic carnitine palmitoyltransferase I deficiency: acylcarnitine profiles in blood spots are highly specific.
Topics: Biomarkers; Blood Specimen Collection; Carnitine; Carnitine O-Palmitoyltransferase; Humans; Infant; Infant, Newborn; Liver; Male; Neonatal Screening; Paper; Sensitivity and Specificity; Spectrometry, Mass, Electrospray Ionization | 2001 |
Oxidation of unsaturated fatty acids by human fibroblasts with very-long-chain acyl-CoA dehydrogenase deficiency: aspects of substrate specificity and correlation with clinical phenotype.
Topics: Acyl-CoA Dehydrogenase, Long-Chain; Acyl-CoA Dehydrogenases; Adult; Carnitine; Case-Control Studies; Cells, Cultured; Child; Child, Preschool; Fatty Acids, Unsaturated; Female; Fibroblasts; Humans; Infant, Newborn; Isomerism; Lipid Metabolism, Inborn Errors; Oleic Acid; Oleic Acids; Oxidation-Reduction; Substrate Specificity | 2001 |
Gestational, pathologic and biochemical differences between very long-chain acyl-CoA dehydrogenase deficiency and long-chain acyl-CoA dehydrogenase deficiency in the mouse.
Topics: Acyl-CoA Dehydrogenase, Long-Chain; Animals; Carnitine; Fatty Acids; Female; Humans; Lipid Metabolism, Inborn Errors; Litter Size; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Mitochondria, Heart; Mitochondria, Liver; Mitochondria, Muscle | 2001 |
Evaluation and application of liquid chromatographic columns coated with 'intelligent' ligands: (I) acylcarnitine column.
Topics: Carnitine; Chromatography, Liquid; Reproducibility of Results; Static Electricity | 2001 |
Prenatal diagnosis of multiple acyl-CoA dehydrogenase deficiency: association with elevated alpha-fetoprotein and cystic renal changes.
Topics: Acyl-CoA Dehydrogenase; Acyl-CoA Dehydrogenases; alpha-Fetoproteins; Amniocentesis; Amniotic Fluid; Carnitine; Diagnosis, Differential; Fatty Liver; Female; Fetal Diseases; Fetal Growth Retardation; Gestational Age; Humans; Oligohydramnios; Polycystic Kidney Diseases; Pregnancy; Prenatal Diagnosis; Ultrasonography, Prenatal | 2001 |
Role of intrapartum hypoxia in carnitine nutritional status during the early neonatal period.
Topics: Carnitine; Chromatography, High Pressure Liquid; Esters; Fetal Hypoxia; Gestational Age; Humans; Hydrogen-Ion Concentration; Infant, Newborn; Lysine; Methionine; Nutritional Status | 2001 |
Cognitive behavioral therapy and fasting therapy for a patient with chronic fatigue syndrome.
Topics: Adult; Carnitine; Cognitive Behavioral Therapy; Fasting; Fatigue Syndrome, Chronic; Humans; Killer Cells, Natural; Lymphocyte Subsets; Male; Time Factors; Treatment Outcome | 2001 |
Characterization of plasma acylcarnitines in patients under valproate monotherapy using ESI-MS/MS.
Topics: Adolescent; Adult; Aged; Anticonvulsants; Carnitine; Female; Humans; Leucine; Male; Middle Aged; Mitochondrial Trifunctional Protein; Multienzyme Complexes; Spectrometry, Mass, Electrospray Ionization; Valerates; Valproic Acid | 2001 |
Acylcarnitine profiles in fibroblasts from patients with respiratory chain defects can resemble those from patients with mitochondrial fatty acid beta-oxidation disorders.
Topics: Carnitine; Cells, Cultured; Fatty Acids; Fibroblasts; Humans; Mitochondria; Mitochondrial Diseases; Oxidation-Reduction; Reference Values | 2002 |
Screening for carnitine palmitoyltransferase II deficiency by tandem mass spectrometry.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Carnitine; Carnitine O-Palmitoyltransferase; Child; Child, Preschool; Female; Humans; Infant; Male; Mass Screening; Mass Spectrometry; Middle Aged; Palmitoylcarnitine | 2002 |
More on the metabolic autopsy.
Topics: Amino Acids; Autopsy; Biopsy; Carnitine; Humans; Infant, Newborn; Metabolism, Inborn Errors; Skin; Sudden Infant Death; Urine | 2002 |
Assessment of plasma carnitine concentrations in relation to ceroid lipofuscinosis in Tibetan Terriers.
Topics: Age Factors; Animals; Carnitine; Cerebral Cortex; Dog Diseases; Dogs; Female; Male; Microscopy, Electron; Microscopy, Fluorescence; Neuronal Ceroid-Lipofuscinoses; Retina; Sex Factors | 2002 |
Serum acylcarnitines and vitamin B12 deficiency.
Topics: Aged; Carnitine; Chromatography, High Pressure Liquid; Female; Humans; Male; Mass Spectrometry; Methylmalonic Acid; Middle Aged; Vitamin B 12 Deficiency | 2002 |
Quantitative fibroblast acylcarnitine profiles in mitochondrial fatty acid beta-oxidation defects: phenotype/metabolite correlations.
Topics: Acyl-CoA Dehydrogenase; Acyl-CoA Dehydrogenase, Long-Chain; Adolescent; Adult; Carnitine; Child; Child, Preschool; Fatty Acid Desaturases; Fatty Acids; Fibroblasts; Humans; Infant; Infant, Newborn; Metabolism, Inborn Errors; Mitochondria; Oxidation-Reduction; Phenotype | 2002 |
Interactions of acyl carnitines with model membranes: a (13)C-NMR study.
Topics: Animals; Carnitine; Cell Membrane; Egg Yolk; Hydrogen-Ion Concentration; Lipid Bilayers; Liposomes; Magnetic Resonance Spectroscopy; Models, Biological; Molecular Structure; Solutions; Water | 2002 |
A method for quantitative acylcarnitine profiling in human skin fibroblasts using unlabelled palmitic acid: diagnosis of fatty acid oxidation disorders and differentiation between biochemical phenotypes of MCAD deficiency.
Topics: Acyl-CoA Dehydrogenase; Acyl-CoA Dehydrogenases; Carnitine; Cells, Cultured; Fibroblasts; Humans; Infant, Newborn; Lipid Metabolism, Inborn Errors; Mitochondria; Palmitic Acid; Phenotype; Sensitivity and Specificity; Skin; Spectrometry, Mass, Electrospray Ionization | 2002 |
Fat oxidation defect presenting with overwhelming ketonuria.
Topics: Acyl-CoA Dehydrogenase, Long-Chain; Brain Diseases, Metabolic; Carnitine; Female; Humans; Hypoglycemia; Infant; Ketone Bodies; Oxidation-Reduction | 2002 |
Comprehensive screening of urine samples for inborn errors of metabolism by electrospray tandem mass spectrometry.
Topics: Amino Acids; Carboxylic Acids; Carnitine; Humans; Mass Screening; Metabolism, Inborn Errors; Spectrometry, Mass, Electrospray Ionization | 2002 |
Identification of two novel mutations in OCTN2 from two Saudi patients with systemic carnitine deficiency.
Topics: Carnitine; Carrier Proteins; Child, Preschool; Humans; Infant; Male; Mass Spectrometry; Membrane Proteins; Mutation, Missense; Organic Cation Transport Proteins; Solute Carrier Family 22 Member 5 | 2002 |
Acylcarnitine profiles of preterm infants over the first four weeks of life.
Topics: Carnitine; Gestational Age; Humans; Infant, Newborn; Infant, Premature; Metabolism, Inborn Errors; Neonatal Screening; Spectrometry, Mass, Electrospray Ionization; Time Factors | 2002 |
Effects of fasting and hypoxic preconditioning on the hypoxic-reoxygenated ventricular strips of the rat heart.
Topics: Acyl Coenzyme A; Analysis of Variance; Animals; Carnitine; Fasting; Heart Ventricles; Hypoxia; Ischemic Preconditioning, Myocardial; Lactic Acid; Myocardial Contraction; Myocardial Reperfusion Injury; Rats; Rats, Wistar | 2002 |
Relative importance of enhanced glucose uptake versus attenuation of long-chain acyl carnitines in protecting ischemic myocardium.
Topics: Animals; Carnitine; Creatine Kinase; Cytochalasin B; Disease Models, Animal; Glucose; Models, Cardiovascular; Myocardial Contraction; Myocardial Ischemia; Myocardial Reperfusion Injury; Niacin; Oxygen Consumption; Rats; Recovery of Function; Stroke Volume; Vasodilator Agents; Ventricular Pressure | 2002 |
Validation of an ESI-MS/MS screening method for acylcarnitine profiling in urine specimens of neonates, children, adolescents and adults.
Topics: Adolescent; Adult; Age Factors; Carnitine; Case-Control Studies; Child; Child, Preschool; Humans; Infant; Infant, Newborn; Mass Screening; Metabolism, Inborn Errors; Reproducibility of Results; Sensitivity and Specificity; Spectrometry, Mass, Electrospray Ionization | 2003 |
Neonatal presentation of ventricular tachycardia and a Reye-like syndrome episode associated with disturbed mitochondrial energy metabolism.
Topics: Biomarkers; Carnitine; DNA, Mitochondrial; Female; Glutarates; Humans; Infant, Newborn; Mitochondrial Myopathies; Mutation; Orotic Acid; Reye Syndrome; Tachycardia, Ventricular | 2002 |
The pattern of urinary acylcarnitines determined by electrospray mass spectrometry: a new tool in the diagnosis of diabetes mellitus.
Topics: Adult; Aged; Body Mass Index; Calibration; Carnitine; Diabetes Mellitus; Humans; Middle Aged; Spectrometry, Mass, Electrospray Ionization | 2003 |
Determination of carnitine and acylcarnitines in urine by high-performance liquid chromatography-electrospray ionization ion trap tandem mass spectrometry.
Topics: Carnitine; Chromatography, High Pressure Liquid; Reproducibility of Results; Spectrometry, Mass, Electrospray Ionization | 2003 |
Characteristic acylcarnitine profiles in inherited defects of peroxisome biogenesis: a novel tool for screening diagnosis using tandem mass spectrometry.
Topics: Carnitine; Gas Chromatography-Mass Spectrometry; Humans; Mass Spectrometry; Peroxisomal Disorders; Peroxisomes | 2003 |
The frequency of short-chain acyl-CoA dehydrogenase gene variants in the US population and correlation with the C(4)-acylcarnitine concentration in newborn blood spots.
Topics: Alleles; Butyryl-CoA Dehydrogenase; Carnitine; Exons; Fatty Acids; Gene Frequency; Genetic Variation; Genetics, Population; Genotype; Heterozygote; Homozygote; Humans; Infant, Newborn; Mass Screening; Mass Spectrometry; Mutation; Phenotype; Scattering, Radiation; Temperature; United States | 2003 |
Expanded newborn screening for inborn errors of metabolism by electrospray ionization-tandem mass spectrometry: results, outcome, and implications.
Topics: Acyl-CoA Dehydrogenase; Amino Acid Metabolism, Inborn Errors; Amino Acids; Carnitine; Cohort Studies; Decision Trees; Evidence-Based Medicine; Fatty Acid Desaturases; Follow-Up Studies; Germany; Humans; Infant, Newborn; Infant, Premature; Infant, Premature, Diseases; Metabolism, Inborn Errors; Neonatal Screening; Predictive Value of Tests; Prospective Studies; Sensitivity and Specificity; Spectrometry, Mass, Electrospray Ionization; Treatment Outcome | 2003 |
Effect of supplementation with L-carnitine at a small dose on acylcarnitine profiles in serum and urine and the renal handling of acylcarnitines in a patient with multiple acyl-coenzyme A dehydrogenation defect.
Topics: Acyl-CoA Dehydrogenase; Carnitine; Humans; Infant, Newborn; Kidney; Male; Metabolism, Inborn Errors; Spectrometry, Mass, Electrospray Ionization | 2003 |
Kinetic analysis of the selectivity of acylcarnitine synthesis in rat mitochondria.
Topics: alpha-Linolenic Acid; Animals; Binding, Competitive; Carnitine; Carnitine O-Palmitoyltransferase; Cattle; Fatty Acids; Fatty Acids, Nonesterified; Kinetics; Male; Mitochondria, Liver; Oleic Acid; Rats; Rats, Sprague-Dawley; Serum Albumin, Bovine | 2003 |
Evaluation of 3-methylcrotonyl-CoA carboxylase deficiency detected by tandem mass spectrometry newborn screening.
Topics: Acids; Carbon-Carbon Ligases; Carnitine; Female; Genetic Testing; Humans; Infant, Newborn; Lymphocytes; Male; Mass Spectrometry; Metabolism, Inborn Errors; Neonatal Screening; North Carolina; Pilot Projects | 2003 |
A novel mitochondrial carnitine-acylcarnitine translocase induced by partial hepatectomy and fasting.
Topics: 3T3 Cells; Amino Acid Sequence; Animals; Biological Transport; Blotting, Northern; Blotting, Western; Brain; Carnitine; Carnitine Acyltransferases; DNA, Complementary; Escherichia coli; Fatty Acids; Food Deprivation; Genetic Complementation Test; Humans; Immunohistochemistry; Lipid Metabolism; Liver; Mice; Mice, Inbred C57BL; Mitochondria; Mitochondrial Proteins; Molecular Sequence Data; Palmitoylcarnitine; Plasmids; Saccharomyces cerevisiae; Sequence Homology, Amino Acid; Time Factors; Tissue Distribution | 2003 |
Adult presentation of MCAD deficiency revealed by coma and severe arrythmias.
Topics: Acyl-CoA Dehydrogenase; Adult; Arrhythmias, Cardiac; Carnitine; Coma; Critical Care; Dicarboxylic Acids; Humans; Male; Metabolism, Inborn Errors; Treatment Outcome | 2003 |
What is the role of medium-chain triglycerides in the management of long-chain 3-hydroxyacyl-CoA dehydrogenase deficiency?
Topics: 3-Hydroxyacyl CoA Dehydrogenases; Carnitine; Child; Child, Preschool; Fatty Acids, Nonesterified; Food, Formulated; Humans; Metabolism, Inborn Errors; Respiratory Mechanics; Triglycerides | 2003 |
A case of mitochondrial trifunctional protein deficiency diagnosed by acylcarnitine profile and DNA analysis in a dried blood spot of a 4-day-old boy.
Topics: Amino Acid Metabolism, Inborn Errors; Carnitine; Cytosine; DNA Mutational Analysis; Fatal Outcome; Guanine; Humans; Infant, Newborn; Male; Mitochondrial Trifunctional Protein; Multienzyme Complexes; Mutation; Protein Isoforms | 2003 |
LONG-CHAIN CARNITINE ACYLTRANSFERASE AND THE ROLE OF ACYLCARNITINE DERIVATIVES IN THE CATALYTIC INCREASE OF FATTY ACID OXIDATION INDUCED BY CARNITINE.
Topics: Acyltransferases; Adenosine Triphosphate; Carbon Isotopes; Carnitine; Carnitine Acyltransferases; Chromatography; Coenzyme A; Lipid Metabolism; Metabolism; Mitochondria; Myocardium; Palmitic Acid; Pharmacology; Research; Tritium; Vitamin B Complex | 1963 |
THE FORMATION AND ISOLATION OF LONG-CHAIN ACYL CARNITINES IN MITOCHONDRIA.
Topics: Animals; Carbon Isotopes; Carnitine; Cattle; Chromatography; Folic Acid; Metabolism; Mitochondria; Myocardium; Palmitic Acid; Phospholipids; Research; Vitamin B Complex | 1965 |
TWO-DIMENSIONAL THIN-LAYER CHROMATOGRAPHIC ISOLATION OF FATTY ACYL CARNITINES.
Topics: Carnitine; Chromatography; Chromatography, Thin Layer; Phospholipids; Research; Vitamin B Complex | 1965 |
Defective hepatic mitochondrial respiratory chain in patients with nonalcoholic steatohepatitis.
Topics: Adult; Body Mass Index; Carnitine; Electron Transport; Fatty Acids; Fatty Liver; Female; Humans; Insulin Resistance; Male; Middle Aged; Mitochondria, Liver; Oxidation-Reduction; Reactive Oxygen Species | 2003 |
The mitochondrial acetoacetyl-CoA thiolase (T2) deficiency in Japanese patients: urinary organic acid and blood acylcarnitine profiles under stable conditions have subtle abnormalities in T2-deficient patients with some residual T2 activity.
Topics: Acetoacetates; Acetyl-CoA C-Acetyltransferase; Amino Acid Metabolism, Inborn Errors; Carnitine; Humans; Hydroxybutyrates; Infant; Isoleucine; Ketone Bodies; Male; Mitochondria; Mutation | 2003 |
A knock-out mouse model for methylmalonic aciduria resulting in neonatal lethality.
Topics: Alkyl and Aryl Transferases; Amino Acid Metabolism, Inborn Errors; Animals; Blotting, Southern; Carnitine; Cell Line; Citrates; DNA; Fibroblasts; Genotype; Homozygote; Liver; Methylmalonic Acid; Methylmalonyl-CoA Mutase; Mice; Mice, Knockout; Mice, Transgenic; Models, Genetic; Phenotype; Plasmids; Protein Structure, Tertiary; RNA, Messenger; Time Factors | 2003 |
A comparison of in vitro acylcarnitine profiling methods for the diagnosis of classical and variant short chain acyl-CoA dehydrogenase deficiency.
Topics: Acyl-CoA Dehydrogenase; Butyric Acid; Butyryl-CoA Dehydrogenase; Carbon Isotopes; Carnitine; Deuterium; DNA Mutational Analysis; Fibroblasts; Heterozygote; Homozygote; Humans; Malonates; Mutation, Missense; Palmitic Acid; Palmitoylcarnitine; Polymorphism, Genetic; Sensitivity and Specificity; Spectrometry, Mass, Electrospray Ionization; Spiro Compounds | 2003 |
Glutaryl-CoA dehydrogenase deficiency: region-specific analysis of organic acids and acylcarnitines in post mortem brain predicts vulnerability of the putamen.
Topics: Acidosis; Acute Disease; Adolescent; Anticonvulsants; Atrophy; Brain; Carnitine; DNA Mutational Analysis; Fatal Outcome; Gas Chromatography-Mass Spectrometry; Gene Expression; Glutarates; Glutaryl-CoA Dehydrogenase; Humans; Male; Muscle Hypotonia; N-Methylaspartate; Oxidoreductases Acting on CH-CH Group Donors; Point Mutation; Putamen; Spasm; Vigabatrin | 2003 |
Rapid diagnosis of medium chain Acyl Co-A dehydrogenase (MCAD) deficiency in a newborn by liquid chromatography/tandem mass spectrometry.
Topics: Acyl-CoA Dehydrogenase; Calibration; Carnitine; Chromatography, High Pressure Liquid; DNA; Humans; Infant, Newborn; Male; Mass Spectrometry; Metabolism, Inborn Errors; Neonatal Screening; Reverse Transcriptase Polymerase Chain Reaction | 2003 |
Respiratory complex II defect in siblings associated with a symptomatic secondary block in fatty acid oxidation.
Topics: Acidosis, Lactic; Acyl-CoA Dehydrogenase; Behavior; Bicarbonates; Carnitine; Cell Line; Fatty Acids; Female; Fibroblasts; Growth; Humans; Infant, Newborn; Lactic Acid; Mitochondrial Diseases; Oxidation-Reduction; Oxidative Phosphorylation; Phenotype | 2003 |
Serum carnitine concentrations correlated to clinical outcome parameters in chronic hemodialysis patients.
Topics: Age Factors; Blood Urea Nitrogen; Carnitine; Diabetes Complications; Diabetes Mellitus; Female; Humans; Kidney Failure, Chronic; Male; Mannitol; Middle Aged; Parathyroid Hormone; Renal Dialysis; Treatment Outcome; Ventricular Dysfunction, Left | 2004 |
Hepatic expression of malonyl-CoA decarboxylase reverses muscle, liver and whole-animal insulin resistance.
Topics: Acyl Coenzyme A; Adenoviridae; Animals; Carboxy-Lyases; Carnitine; Cells, Cultured; Dietary Fats; Hepatocytes; Insulin; Insulin Resistance; Lipid Metabolism; Liver; Male; Muscle, Skeletal; Rats; Rats, Wistar; Triglycerides | 2004 |
Blood acylcarnitine levels in normal newborns and heterozygotes for medium-chain acyl-CoA dehydrogenase deficiency: a relationship between genotype and biochemical phenotype?
Topics: Acyl-CoA Dehydrogenase; Adenine; Carnitine; Diagnosis, Differential; Gene Frequency; Genotype; Guanine; Heterozygote; Humans; Infant, Low Birth Weight; Infant, Newborn; Metabolism, Inborn Errors; Osmolar Concentration; Phenotype | 2004 |
Changes in blood carnitine and acylcarnitine profiles of very long-chain acyl-CoA dehydrogenase-deficient mice subjected to stress.
Topics: Acyl-CoA Dehydrogenase, Long-Chain; Animals; Biomarkers; Blood Glucose; Carnitine; Cold Temperature; Fasting; Mice; Mice, Knockout; Motor Activity; Phenotype; Stress, Physiological | 2004 |
Synthesis of dicarboxylic acylcarnitines.
Topics: Carnitine; Deuterium; Dicarboxylic Acids; Magnetic Resonance Spectroscopy; Spectrometry, Mass, Electrospray Ionization | 2004 |
Determination of carnitine and acylcarnitines in plasma by high-performance liquid chromatography/electrospray ionization ion trap tandem mass spectrometry.
Topics: Calibration; Carnitine; Chromatography, High Pressure Liquid; Humans; Methylmalonic Acid; Reference Standards; Reproducibility of Results; Sensitivity and Specificity; Spectrometry, Mass, Electrospray Ionization | 2004 |
Homozygosity for a severe novel medium-chain acyl-CoA dehydrogenase (MCAD) mutation IVS3-1G > C that leads to introduction of a premature termination codon by complete missplicing of the MCAD mRNA and is associated with phenotypic diversity ranging from s
Topics: Acyl-CoA Dehydrogenase; Adult; Alternative Splicing; Arabs; Base Sequence; Carnitine; Child; Codon, Nonsense; Female; Homozygote; Humans; Infant, Newborn; Male; Mutation; Oxidation-Reduction; Pedigree; Phenotype; RNA, Messenger; Sudden Infant Death | 2004 |
Pseudo-glutarylcarnitinaemia in medium-chain acyl-CoA dehydrogenase deficiency detected by tandem mass spectrometry newborn screening.
Topics: Acetylation; Acyl-CoA Dehydrogenase; Carnitine; False Positive Reactions; Fatty Acids; Gas Chromatography-Mass Spectrometry; Humans; Infant, Newborn; Mass Spectrometry; Neonatal Screening; Oxidation-Reduction; Sensitivity and Specificity | 2004 |
Genetic and biochemical study in a patient with glutaric acidemia type I.
Topics: Amino Acid Metabolism, Inborn Errors; Carnitine; Child, Preschool; Glutarates; Glutaryl-CoA Dehydrogenase; Humans; Male; Mutation; Oxidoreductases Acting on CH-CH Group Donors | 2004 |
Dobutamine alters carnitine metabolism in the neonatal piglet heart.
Topics: Animals; Animals, Newborn; Cardiotonic Agents; Carnitine; Coronary Circulation; Dobutamine; Dose-Response Relationship, Drug; Heart Rate; In Vitro Techniques; Myocardium; Swine; Ventricular Function, Left; Ventricular Pressure | 2004 |
Isobutyryl-CoA dehydrogenase deficiency: isobutyrylglycinuria and ACAD8 gene mutations in two infants.
Topics: Acyl-CoA Dehydrogenases; Carnitine; Female; Frameshift Mutation; Humans; Infant, Newborn; Male; Mass Spectrometry; Mutation; Mutation, Missense; Neonatal Screening; Oxidoreductases Acting on CH-CH Group Donors | 2004 |
Peroxisome proliferator activated receptor delta (PPARdelta) agonist but not PPARalpha corrects carnitine palmitoyl transferase 2 deficiency in human muscle cells.
Topics: Adult; Bezafibrate; Butyrates; Carnitine; Carnitine O-Palmitoyltransferase; Cells, Cultured; Dose-Response Relationship, Drug; Enzyme Activation; Gene Expression; Humans; Hypolipidemic Agents; Muscle Fibers, Skeletal; Palmitic Acid; Phenylurea Compounds; Point Mutation; PPAR gamma; Thiazoles; Tritium | 2005 |
Quantitation of long-chain acylcarnitines by HPLC/fluorescence detection: application to plasma and tissue specimens from patients with carnitine palmitoyltransferase-II deficiency.
Topics: Carnitine; Carnitine O-Palmitoyltransferase; Chromatography, High Pressure Liquid; Humans; Lipid Metabolism, Inborn Errors; Sensitivity and Specificity; Spectrometry, Fluorescence | 2005 |
Filter paper cards contaminated with EMLA cream produce artefacts on acylcarnitine analysis.
Topics: Carnitine; Chemistry, Clinical; Humans; Lidocaine; Prilocaine; Spectrometry, Mass, Electrospray Ionization; Time Factors | 2004 |
Age-related variations in acylcarnitine and free carnitine concentrations measured by tandem mass spectrometry.
Topics: Adolescent; Adult; Age Factors; Blood Specimen Collection; Carnitine; Child; Child, Preschool; Female; Fetal Blood; Humans; Infant; Infant, Newborn; Male; Mass Spectrometry; Middle Aged; Reference Values; Sex Factors | 2005 |
Serum carnitine levels in patients with homozygous beta thalassemia: a possible new role for carnitine?
Topics: Adolescent; Adult; beta-Thalassemia; Carnitine; Case-Control Studies; Child; Child, Preschool; Fatty Acids; Female; Homozygote; Humans; Male; Muscle Weakness; Surveys and Questionnaires | 2005 |
Strategy for the isolation, derivatization, chromatographic separation, and detection of carnitine and acylcarnitines.
Topics: Acetonitriles; Acetophenones; Acetylcarnitine; Animals; Blood Chemical Analysis; Carnitine; Chemical Precipitation; Chromatography, High Pressure Liquid; Chromatography, Ion Exchange; Humans; Liver; Male; Mass Spectrometry; Methanol; Molecular Structure; Palmitoylcarnitine; Rats; Rats, Sprague-Dawley; Reproducibility of Results; Serum Albumin; Silica Gel; Silicon Dioxide; Solid Phase Extraction | 2005 |
Tissue carnitine homeostasis in very-long-chain acyl-CoA dehydrogenase-deficient mice.
Topics: Acyl-CoA Dehydrogenase, Long-Chain; Animals; Bile; Carnitine; Disease Models, Animal; Homeostasis; Humans; Lipid Metabolism, Inborn Errors; Liver; Mice; Mice, Knockout; Muscle, Skeletal; Phenotype | 2005 |
Abnormal concentrations of esterified carnitine in bile: a feature of pediatric acute liver failure with poor prognosis.
Topics: Bile; Carnitine; Case-Control Studies; Child; Esterification; Humans; Liver; Liver Failure, Acute; Liver Transplantation; Osmolar Concentration; Retrospective Studies; Risk | 2005 |
Accumulation of long-chain acylcarnitine and 3-hydroxy acylcarnitine molecular species in diabetic myocardium: identification of alterations in mitochondrial fatty acid processing in diabetic myocardium by shotgun lipidomics.
Topics: Animals; Base Sequence; Cardiomyopathies; Carnitine; Cricetinae; Diabetes Mellitus, Experimental; DNA; Group VI Phospholipases A2; Hydroxylation; Insulin; Male; Mice; Mice, Transgenic; Myocardial Ischemia; Myocardium; Phospholipases A; Rats; Rats, Sprague-Dawley; RNA, Messenger; Spectrometry, Mass, Electrospray Ionization | 2005 |
Lack of correlation between fatty acid oxidation disorders and haemolysis, elevated liver enzymes, low platelets (HELLP) syndrome?
Topics: 3-Hydroxyacyl CoA Dehydrogenases; Adult; Carnitine; Case-Control Studies; DNA Mutational Analysis; Female; HELLP Syndrome; Humans; Infant, Newborn; Male; Metabolism, Inborn Errors; Pregnancy; Retrospective Studies; Risk Factors | 2005 |
Mitochondrial glycerol-3-phosphate acyltransferase-1 is essential in liver for the metabolism of excess acyl-CoAs.
Topics: Animals; Carnitine; Coenzyme A; Dietary Fats; Dietary Sucrose; Fatty Liver; Female; Glycerol-3-Phosphate O-Acyltransferase; Insulin Resistance; Ketones; Lipids; Liver; Lysophospholipids; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Mitochondria; Obesity; Oxidation-Reduction; Triglycerides; Weight Gain | 2005 |
Effect of methanol on endogenous and exogenous carnitine levels in rat plasma.
Topics: Alcoholic Intoxication; Animals; Area Under Curve; Carnitine; Dose-Response Relationship, Drug; Half-Life; Lethal Dose 50; Male; Metabolic Clearance Rate; Methanol; Random Allocation; Rats; Rats, Sprague-Dawley; Survival Analysis | 2005 |
In vitro correction of medium chain acyl CoA dehydrogenase deficiency with a recombinant adenoviral vector.
Topics: Acyl-CoA Dehydrogenase; Adenoviridae; Animals; Carnitine; Cattle; Cell Line; Cytomegalovirus; Fibroblasts; Gene Transfer Techniques; Genes, Immediate-Early; Genetic Vectors; Humans; Mass Spectrometry; Promoter Regions, Genetic; RNA 3' Polyadenylation Signals | 2005 |
Biochemical, clinical and molecular findings in LCHAD and general mitochondrial trifunctional protein deficiency.
Topics: Acyl-CoA Dehydrogenase, Long-Chain; Cardiomyopathies; Carnitine; Exons; Fatty Acids; Fibroblasts; Homozygote; Humans; Lipid Metabolism, Inborn Errors; Male; Mitochondria; Mitochondrial Trifunctional Protein; Multienzyme Complexes; Mutation; Phenotype; Polyneuropathies; Prognosis; Rhabdomyolysis | 2005 |
Normal acylcarnitine levels during confirmation of abnormal newborn screening in long-chain fatty acid oxidation defects.
Topics: Acyl-CoA Dehydrogenase, Long-Chain; Carnitine; Genotype; Humans; Infant, Newborn; Lipid Metabolism, Inborn Errors; Male; Mass Spectrometry; Mitochondrial Trifunctional Protein; Multienzyme Complexes; Mutation; Neonatal Screening; Oxygen; Time Factors | 2005 |
Newborns with C8-acylcarnitine level over the 90th centile have an increased frequency of the common MCAD 985A>G mutation.
Topics: Acyl-CoA Dehydrogenase; Alleles; Carnitine; DNA Mutational Analysis; Fatty Acids; Heterozygote; Humans; Infant, Newborn; Lipid Metabolism, Inborn Errors; Mass Spectrometry; Mutation; Neonatal Screening; Oxygen; Spectrometry, Mass, Electrospray Ionization | 2005 |
Ontogeny and kinetics of carnitine palmitoyltransferase in liver and skeletal muscle of the domestic felid (Felis domestica).
Topics: Animals; Carnitine; Carnitine O-Palmitoyltransferase; Cats; Kinetics; Liver; Muscle, Skeletal | 2005 |
Plasma and urinary carnitine and acylcarnitines in chronic fatigue syndrome.
Topics: Adult; Aged; Aged, 80 and over; Arthritis, Rheumatoid; Carnitine; Case-Control Studies; Depression; Fatigue Syndrome, Chronic; Female; Humans; Male; Middle Aged; Muscle Fatigue | 2005 |
Pregnancy increases urinary loss of carnitine and reduces plasma carnitine in Korean women.
Topics: Adult; Analysis of Variance; Birth Weight; Carnitine; Case-Control Studies; Cholesterol; Female; Fetal Blood; Humans; Infant, Newborn; Korea; Lipids; Pregnancy; Pregnancy Trimesters; Triglycerides | 2005 |
Carnitine levels in valproic acid-treated psychiatric patients: a cross-sectional study.
Topics: Adult; Aged; Amylases; Anticonvulsants; Carnitine; Cross-Sectional Studies; Female; Humans; Liver Function Tests; Male; Mental Disorders; Middle Aged; Valproic Acid | 2005 |
Acute valproate poisoning: pharmacokinetics, alteration in fatty acid metabolism, and changes during therapy.
Topics: Anticonvulsants; Brain Edema; Carnitine; Drug Overdose; Fatty Acids; Female; Humans; Hyperammonemia; Male; Mitochondria; Oxidation-Reduction; Pancreatitis; Renal Dialysis; Valproic Acid | 2005 |
Rapid measurement of plasma acylcarnitines by liquid chromatography-tandem mass spectrometry without derivatization.
Topics: Acylation; Carnitine; Chromatography, Liquid; Mass Spectrometry; Sensitivity and Specificity; Time Factors | 2005 |
Bezafibrate increases very-long-chain acyl-CoA dehydrogenase protein and mRNA expression in deficient fibroblasts and is a potential therapy for fatty acid oxidation disorders.
Topics: Acyl-CoA Dehydrogenase, Long-Chain; Bezafibrate; Blotting, Western; Carnitine; DNA Primers; Dose-Response Relationship, Drug; Fibroblasts; Gene Expression Regulation, Enzymologic; Humans; Lipid Metabolism, Inborn Errors; Mitochondria; Mutation, Missense; Palmitates; Peroxisome Proliferator-Activated Receptors; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger | 2005 |
Novel metabolic and molecular findings in hepatic carnitine palmitoyltransferase I deficiency.
Topics: Adult; Carnitine; Carnitine O-Palmitoyltransferase; Child, Preschool; Dicarboxylic Acids; Female; Glutarates; Humans; Infant; Male; Mutation; Palmitates | 2005 |
Impact of haemodialysis on individual endogenous plasma acylcarnitine concentrations in end-stage renal disease.
Topics: Adolescent; Adult; Aged; Carnitine; Female; Humans; Kidney Failure, Chronic; Male; Middle Aged; Renal Dialysis; Spectrometry, Mass, Electrospray Ionization | 2005 |
Quantitative acylcarnitine profiling in peripheral blood mononuclear cells using in vitro loading with palmitic and 2-oxoadipic acids: biochemical confirmation of fatty acid oxidation and organic acid disorders.
Topics: Adipates; Carnitine; Child; Child, Preschool; Female; Humans; Infant; Male; Mass Spectrometry; Metabolism, Inborn Errors; Monocytes; Palmitic Acid | 2005 |
Acidified acetonitrile and methanol extractions for quantitative analysis of acylcarnitines in plasma by stable isotope dilution tandem mass spectrometry.
Topics: Acetonitriles; Carnitine; Chemical Fractionation; Glutarates; Humans; Isotope Labeling; Mass Spectrometry; Metabolism, Inborn Errors; Methanol; Reproducibility of Results | 2005 |
Modified and improved method for the measurement of plasma acylcarnitines by online extraction coupled to liquid chromatography-tandem mass spectrometry without derivatization.
Topics: Carnitine; Chromatography, Liquid; Humans; Mass Spectrometry; Reproducibility of Results | 2006 |
Effect of L-carnitine on the kinetics of carnitine, acylcarnitines and butyrobetaine in long-term haemodialysis.
Topics: Adult; Aged; Betaine; Carnitine; Female; Humans; Male; Middle Aged; Renal Dialysis; Time Factors | 2006 |
Medium-chain acyl-CoA dehydrogenase deficiency: genotype-biochemical phenotype correlations.
Topics: Acyl-CoA Dehydrogenase; Carnitine; DNA Mutational Analysis; Fibroblasts; Genetic Testing; Genetic Variation; Genotype; Glycine; Homozygote; Humans; Infant, Newborn; Mass Spectrometry; Phenotype; Statistics as Topic | 2006 |
Differentiation of long-chain fatty acid oxidation disorders using alternative precursors and acylcarnitine profiling in fibroblasts.
Topics: 3-Hydroxyacyl CoA Dehydrogenases; Acetyl-CoA C-Acyltransferase; Acyl-CoA Dehydrogenase, Long-Chain; Adolescent; Carbon-Carbon Double Bond Isomerases; Carnitine; Cells, Cultured; Clinical Enzyme Tests; Diagnosis, Differential; DNA, Complementary; Enoyl-CoA Hydratase; Fatty Acids; Fibroblasts; Genetic Testing; Humans; Infant, Newborn; Lipid Metabolism, Inborn Errors; Mitochondrial Trifunctional Protein; Multienzyme Complexes; Oxidation-Reduction; Racemases and Epimerases | 2006 |
Measurement of stable isotopic enrichment and concentration of long-chain fatty acyl-carnitines in tissue by HPLC-MS.
Topics: Animals; Carbon Isotopes; Carnitine; Chromatography, High Pressure Liquid; Deuterium; Fluorocarbons; Male; Methods; Muscle, Skeletal; Palmitic Acid; Palmitoylcarnitine; Rabbits; Reference Standards; Reproducibility of Results; Spectrometry, Mass, Electrospray Ionization | 2006 |
Carnitine treatment inhibits increases in cerebral carnitine esters and glutamate detected by mass spectrometry after hypoxia-ischemia in newborn rats.
Topics: Animals; Animals, Newborn; Anions; Brain; Cardiolipins; Carnitine; Carnitine O-Acetyltransferase; Glutamates; Glutamic Acid; Glycine; Hypoxia; Hypoxia-Ischemia, Brain; Immunohistochemistry; Lipid Metabolism; Mass Spectrometry; Microscopy, Fluorescence; Mitochondria; Phospholipids; Rats; Rats, Wistar; Superoxides; Time Factors; Vitamin B Complex | 2006 |
Bile acylcarnitine profiles in pediatric liver disease do not interfere with the diagnosis of long-chain fatty acid oxidation defects.
Topics: Bile; Biopsy; Carnitine; Fatty Acids; Humans; Infant; Liver Diseases; Oxidation-Reduction | 2006 |
Rhabdomyolysis in early-onset very long-chain acyl-CoA dehydrogenase deficiency despite normal glucose after fasting.
Topics: Acyl-CoA Dehydrogenase, Long-Chain; Blood Glucose; Carnitine; Fasting; Glucose; Humans; Hypoglycemia; Infant; Metabolism, Inborn Errors; Rhabdomyolysis | 2005 |
Glucose and leucine kinetics in idiopathic ketotic hypoglycaemia.
Topics: Alanine; Amino Acids, Branched-Chain; Basal Metabolism; Calorimetry, Indirect; Carnitine; Case-Control Studies; Child; Child, Preschool; Fasting; Female; Glucose; Humans; Hypoglycemia; Infant; Insulin; Ketosis; Leucine; Male | 2006 |
Carnitine concentrations in term and preterm newborns at birth and during the first days of life.
Topics: Carnitine; Female; Fetal Blood; Humans; Infant, Newborn; Infant, Premature; Male | 2005 |
Two newborns with nutritional vitamin B12 deficiency: challenges in newborn screening for vitamin B12 deficiency.
Topics: Acyl-CoA Dehydrogenase, Long-Chain; Anemia, Pernicious; Autoimmune Diseases; Biomarkers; Carnitine; Citrates; Cystathionine; False Negative Reactions; Female; Gastric Bypass; Heterozygote; Homocysteine; Humans; Hydroxocobalamin; Infant Food; Infant, Newborn; Malabsorption Syndromes; Male; Mass Spectrometry; Maternal-Fetal Exchange; Methylmalonic Acid; Neonatal Screening; Pregnancy; Pregnancy Complications; Vitamin B 12 Deficiency | 2005 |
So doctor, what exactly is wrong with my muscles? Glutaric aciduria type II presenting in a teenager.
Topics: Acyl-CoA Dehydrogenase; Adolescent; Carnitine; DNA Mutational Analysis; Electron-Transferring Flavoproteins; Female; Glutarates; Humans; Iron-Sulfur Proteins; Metabolism, Inborn Errors; Muscular Diseases; Oxidoreductases Acting on CH-NH Group Donors | 2006 |
Functional expression of the organic cation/carnitine transporter 2 in rat astrocytes.
Topics: Animals; Astrocytes; Blotting, Western; Carnitine; Cation Transport Proteins; Cells, Cultured; Dose-Response Relationship, Drug; Drug Interactions; Gene Expression; Glial Fibrillary Acidic Protein; Organic Cation Transport Proteins; Rats; Rats, Sprague-Dawley; RNA, Messenger; RNA, Small Interfering; Solute Carrier Family 22 Member 5; Transfection; Tritium | 2006 |
Relationship between serum carnitine, acylcarnitines, and renal function in patients with chronic renal disease.
Topics: Adult; Carnitine; Cross-Sectional Studies; Female; Glomerular Filtration Rate; Humans; Kidney; Kidney Failure, Chronic; Male; Middle Aged | 2006 |
Intracerebral accumulation of glutaric and 3-hydroxyglutaric acids secondary to limited flux across the blood-brain barrier constitute a biochemical risk factor for neurodegeneration in glutaryl-CoA dehydrogenase deficiency.
Topics: Amino Acids; Animals; Biological Transport; Blood-Brain Barrier; Blotting, Western; Brain; Carnitine; Cells, Cultured; Dicarboxylic Acids; Disease Models, Animal; Endothelial Cells; Glucose; Glutarates; Glutaryl-CoA Dehydrogenase; Heart; Liver; Mice; Mice, Inbred C57BL; Mice, Knockout; Models, Biological; Muscles; Neurodegenerative Diseases; Risk Factors; Statistics, Nonparametric; Swine; Time Factors; Tissue Distribution | 2006 |
Refining the diagnosis of mitochondrial HMG-CoA synthase deficiency.
Topics: Carnitine; DNA Mutational Analysis; Genotype; Heterozygote; Humans; Hydroxymethylglutaryl-CoA Synthase; Infant; Male; Metabolism, Inborn Errors; Mitochondrial Diseases; Mutation | 2006 |
A monotopic membrane protein goes solo.
Topics: Animals; Binding Sites; Carnitine; Carnitine O-Palmitoyltransferase; Catalysis; Cell Membrane; Coenzyme A; Crystallography, X-Ray; Escherichia coli; Fatty Acids; Lipid Bilayers; Molecular Conformation; Protein Binding; Protein Conformation; Protein Structure, Tertiary; Rats; Recombinant Proteins; Solubility; Substrate Specificity | 2006 |
Time course of acylcarnitine elevation in neonatal intrahepatic cholestasis caused by citrin deficiency.
Topics: Alanine; Amino Acid Metabolism, Inborn Errors; Calcium-Binding Proteins; Carnitine; Cholestasis, Intrahepatic; Humans; Infant; Infant, Newborn; Mass Spectrometry; Membrane Transport Proteins; Models, Biological; Neonatal Screening; Organic Anion Transporters; Time Factors | 2006 |
Influence of hematocrit and localisation of punch in dried blood spots on levels of amino acids and acylcarnitines measured by tandem mass spectrometry.
Topics: Amino Acids; Blood Specimen Collection; Blood Stains; Carnitine; Glycine; Hematocrit; Humans; Sensitivity and Specificity; Tandem Mass Spectrometry | 2006 |
Short-term effects of nocturnal haemodialysis on carnitine metabolism.
Topics: Adult; Biological Factors; Carnitine; Circadian Rhythm; Colorimetry; Disease Progression; Female; Follow-Up Studies; Humans; Kidney Failure, Chronic; Male; Middle Aged; Prognosis; Prospective Studies; Renal Dialysis; Time Factors | 2006 |
Pitfalls of neonatal screening for very-long-chain acyl-CoA dehydrogenase deficiency using tandem mass spectrometry.
Topics: Acyl-CoA Dehydrogenase, Long-Chain; Carnitine; Child, Preschool; Female; Genetic Carrier Screening; Humans; Infant, Newborn; Metabolism, Inborn Errors; Mutation, Missense; Neonatal Screening; Spectrometry, Mass, Electrospray Ionization | 2006 |
Effect of temperature on the stability of long-chain acylcarnitines in human blood prior to plasma separation.
Topics: Adult; Blood Preservation; Carnitine; Clinical Laboratory Techniques; Female; Humans; Male; Middle Aged; Temperature | 2007 |
Carnitine transporter defect: diagnosis in asymptomatic adult women following analysis of acylcarnitines in their newborn infants.
Topics: Adult; Carnitine; Consanguinity; Female; Fetal Blood; Humans; Infant, Newborn; Male; Mass Spectrometry; Metabolism, Inborn Errors; Mothers; Organic Cation Transport Proteins; Oxygen; Solute Carrier Family 22 Member 5 | 2006 |
Picolinyl ester fragmentation mechanism studies with application to the identification of acylcarnitine acyl groups following transesterification.
Topics: Acylation; Carnitine; Esters; Gas Chromatography-Mass Spectrometry; Picolinic Acids; Spectrometry, Mass, Electrospray Ionization | 2006 |
Prolonged moderate-intensity exercise without and with L-carnitine supplementation in patients with MCAD deficiency.
Topics: Acyl-CoA Dehydrogenase; Adolescent; Adult; Amino Acid Metabolism, Inborn Errors; Carnitine; Child; Dietary Supplements; Exercise; Fatty Acids; Female; Humans; Male; Time Factors | 2006 |
Total carnitine and acylated carnitine ratio: relationship of free carnitine with lipid parameters in pediatric dialysis patients.
Topics: Adolescent; Body Height; Body Weight; Carnitine; Child; Child, Preschool; Female; Humans; Infant; Lipids; Male; Peritoneal Dialysis; Renal Dialysis | 2006 |
Frequency of low carnitine levels in children on dialysis.
Topics: Adolescent; Carnitine; Child; Female; Humans; Male; Peritoneal Dialysis; Renal Dialysis | 2006 |
Normal muscle respiratory chain enzymes can complicate mitochondrial disease diagnosis.
Topics: Acidosis, Lactic; Atrophy; Biopsy; Blotting, Western; Carnitine; Central Nervous System Cysts; Cerebral Ventricles; Diagnosis, Differential; DNA Mutational Analysis; Electron Transport Complex I; Female; Fibroblasts; Frontal Lobe; Humans; Infant, Newborn; Magnetic Resonance Imaging; Mitochondrial Diseases; Muscle, Skeletal; Nerve Fibers, Myelinated; Point Mutation | 2006 |
Studies on the critical micellar concentration and phase transitions of stearoylcarnitine.
Topics: Biophysics; Calorimetry, Differential Scanning; Carnitine; Hydrogen-Ion Concentration; Micelles; Models, Molecular; Spectrometry, Fluorescence; Stearic Acids; Temperature; Water | 2006 |
Late-onset multiple acyl-CoA dehydrogenase deficiency: a frequently missed diagnosis?
Topics: Acyl-CoA Dehydrogenase; Carnitine; Diagnostic Errors; Electron-Transferring Flavoproteins; Heterozygote; Humans; Iron-Sulfur Proteins; Male; Mass Spectrometry; Metabolism, Inborn Errors; Middle Aged; Muscular Diseases; Mutation; Oxidoreductases Acting on CH-NH Group Donors | 2006 |
Tandem mass neonatal screening in Taiwan--report from one center.
Topics: Amino Acids; Carnitine; Female; Humans; Infant, Newborn; Male; Mass Spectrometry; Metabolism, Inborn Errors; Neonatal Screening; Taiwan | 2006 |
ENU mutagenesis identifies mice with cardiac fibrosis and hepatic steatosis caused by a mutation in the mitochondrial trifunctional protein beta-subunit.
Topics: Adipose Tissue; Animals; Base Sequence; Blotting, Western; Carnitine; Chromosome Mapping; Ethylnitrosourea; Fatty Liver; Female; Fibrosis; Lipid Metabolism Disorders; Male; Mice; Mice, Inbred C57BL; Mitochondrial Trifunctional Protein; Mitochondrial Trifunctional Protein, alpha Subunit; Mitochondrial Trifunctional Protein, beta Subunit; Multienzyme Complexes; Mutagenesis; Myocardium; Point Mutation; Polymerase Chain Reaction; Pregnancy; Tandem Mass Spectrometry | 2006 |
Identification of novel mutations of the HADHA and HADHB genes in patients with mitochondrial trifunctional protein deficiency.
Topics: Amino Acid Metabolism, Inborn Errors; Amino Acid Sequence; Base Sequence; Carnitine; Child; Child, Preschool; DNA Mutational Analysis; Female; Humans; Infant, Newborn; Male; Mitochondrial Trifunctional Protein; Mitochondrial Trifunctional Protein, alpha Subunit; Mitochondrial Trifunctional Protein, beta Subunit; Molecular Sequence Data; Multienzyme Complexes; Mutation; Sequence Homology, Amino Acid; Tandem Mass Spectrometry | 2007 |
Effects of valproate on acylcarnitines in children with epilepsy using ESI-MS/MS.
Topics: Adolescent; Anticonvulsants; Carbamazepine; Carnitine; Chemical and Drug Induced Liver Injury; Child; Child, Preschool; Cross-Sectional Studies; Epilepsy; Female; Humans; Infant; Longitudinal Studies; Male; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry; Valproic Acid | 2007 |
Long-term stability of amino acids and acylcarnitines in dried blood spots.
Topics: Amino Acids; Blood Specimen Collection; Carnitine; Humans; Infant, Newborn; Linear Models; Metabolism, Inborn Errors; Models, Biological; Neonatal Screening; Time Factors | 2007 |
Simultaneous quantification of acylcarnitine isomers containing dicarboxylic acylcarnitines in human serum and urine by high-performance liquid chromatography/electrospray ionization tandem mass spectrometry.
Topics: Adult; Carnitine; Child, Preschool; Female; Humans; Isomerism; Male; Metabolism, Inborn Errors; Methylmalonic Acid; Methylmalonyl-CoA Mutase; Spectrometry, Mass, Electrospray Ionization | 2007 |
ESI-MS/MS study of acylcarnitine profiles in urine from patients with organic acidemias and fatty acid oxidation disorders.
Topics: Carnitine; Fatty Acids; Humans; Infant; Lipid Metabolism, Inborn Errors; Metabolism, Inborn Errors; Methylmalonic Acid; Oxidation-Reduction; Propionates; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry | 2007 |
Development of a newborn screening follow-up algorithm for the diagnosis of isobutyryl-CoA dehydrogenase deficiency.
Topics: Acyl-CoA Dehydrogenases; Algorithms; Carnitine; Diagnosis, Differential; Genetic Testing; Humans; Infant, Newborn; Oxidoreductases Acting on CH-CH Group Donors; United States | 2007 |
Carnitine revisited: potential use as adjunctive treatment in diabetes.
Topics: Animals; Calorimetry; Carnitine; Diabetes Mellitus, Experimental; Fatty Acids; Glucose Tolerance Test; Glycerol; Insulin Resistance; Male; Mass Spectrometry; Mice; Mice, Obese; Pyruvate Dehydrogenase (Lipoamide); Vitamin B Complex | 2007 |
2-methylbutyryl-CoA dehydrogenase deficiency in Hmong infants identified by expanded newborn screen.
Topics: Amino Acid Metabolism, Inborn Errors; Carnitine; Ethnicity; Humans; Infant, Newborn; Mass Spectrometry; Neonatal Screening; Oxidoreductases Acting on CH-CH Group Donors; Vietnam; Wisconsin | 2007 |
Serum carnitine, triglyceride and cholesterol profiles in Korean neonates.
Topics: Birth Weight; Carnitine; Cholesterol; Cholesterol, HDL; Cholesterol, LDL; Female; Gestational Age; Humans; Infant, Low Birth Weight; Infant, Newborn; Korea; Male; Triglycerides | 2007 |
A novel functional assay for simultaneous determination of total fatty acid beta-oxidation flux and acylcarnitine profiling in human skin fibroblasts using (2)H(31)-palmitate by isotope ratio mass spectrometry and electrospray tandem mass spectrometry.
Topics: Carnitine; Cell Line; Deuterium; Fatty Acids; Fibroblasts; Humans; Lipid Metabolism, Inborn Errors; Mitochondria; Multienzyme Complexes; Oxidation-Reduction; Palmitates; Skin; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry | 2007 |
Carnitine, acylcarnitine and amino acid profiles analyzed by tandem mass spectrometry in a surfactant/virus mouse model of acute hepatic encephalopathy.
Topics: Amino Acids; Animals; Carnitine; Disease Models, Animal; Hepatic Encephalopathy; Influenza B virus; Mice; Surface-Active Agents; Tandem Mass Spectrometry; Time Factors | 2007 |
Prospective treatment in carnitine-acylcarnitine translocase deficiency.
Topics: Carnitine; Carnitine Acyltransferases; Dicarboxylic Acids; Diet, Fat-Restricted; Dietary Supplements; Fatty Acids; Humans; Hyperammonemia; Hypoglycemia; Infant; Male; Membrane Transport Proteins; Metabolism, Inborn Errors; Oxidation-Reduction; Pedigree; Phenotype; Severity of Illness Index; Treatment Outcome | 2007 |
ETFDH mutations as a major cause of riboflavin-responsive multiple acyl-CoA dehydrogenation deficiency.
Topics: Acyl-CoA Dehydrogenase; Adolescent; Adult; Brain Diseases, Metabolic; Carnitine; Child; Child, Preschool; Electron Transport; Electron-Transferring Flavoproteins; Fatty Acids; Female; Humans; Iron-Sulfur Proteins; Male; Metabolism, Inborn Errors; Mitochondria, Muscle; Mitochondrial Myopathies; Muscle, Skeletal; Mutation; Oxidation-Reduction; Oxidoreductases Acting on CH-NH Group Donors; Riboflavin | 2007 |
Expanded newborn screening in Europe 2007.
Topics: Amino Acids; Carnitine; Europe; Humans; Infant, Newborn; Metabolism, Inborn Errors; Neonatal Screening; Outcome Assessment, Health Care; Spectrometry, Mass, Electrospray Ionization | 2007 |
cis-3,4-Methylene-heptanoylcarnitine: characterization and verification of the C8:1 acylcarnitine in human urine.
Topics: Carnitine; Chromatography, High Pressure Liquid; Esters; Gas Chromatography-Mass Spectrometry; Humans; Spectrometry, Mass, Electrospray Ionization | 2007 |
Fatty acid chain-elongation in perfused rat heart: synthesis of stearoylcarnitine from perfused palmitate.
Topics: Animals; Carnitine; Chromatography, High Pressure Liquid; Fatty Acids; Glucose; Myocardium; Palmitates; Perfusion; Rats; Rats, Inbred F344 | 2007 |
A new LC-ESI-MS/MS method to measure long-chain acylcarnitine levels in cultured cells.
Topics: Acetonitriles; Animals; Carnitine; Carnitine O-Palmitoyltransferase; Chromatography, High Pressure Liquid; Formates; Mitochondria; Palmitoyl Coenzyme A; PC12 Cells; Rats; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry; Transfection | 2007 |
Choice of oils for essential fat supplements can enhance production of abnormal metabolites in fat oxidation disorders.
Topics: Acyl-CoA Dehydrogenase, Long-Chain; Carnitine; Cell Line; Diet Therapy; Dietary Fats; Energy Intake; Fibroblasts; Lipid Metabolism, Inborn Errors; Multienzyme Complexes; Oils; Oxidation-Reduction; Polyneuropathies | 2007 |
Metabolomics identifies perturbations in human disorders of propionate metabolism.
Topics: Acetylcarnitine; Adult; Amino Acid Metabolism, Inborn Errors; Betaine; Biomarkers; Carnitine; Child; Chromatography, High Pressure Liquid; Humans; Methylmalonic Acid; Plasma; Propionates; Spectrometry, Mass, Electrospray Ionization | 2007 |
Carnitine is associated with fatty acid metabolism in plants.
Topics: Arabidopsis; Brassica rapa; Carnitine; Chromatography, Gas; Chromatography, High Pressure Liquid; Fatty Acids; Flax; Nicotiana; Plants; Tandem Mass Spectrometry | 2007 |
Separation and identification of plasma short-chain acylcarnitine isomers by HPLC/MS/MS for the differential diagnosis of fatty acid oxidation defects and organic acidemias.
Topics: Carnitine; Chromatography, High Pressure Liquid; Female; Humans; Isomerism; Male; Tandem Mass Spectrometry | 2007 |
No mutation was found in the alpha-subunit of the mitochondrial tri-functional protein in one patient with severe acute fatty liver of pregnancy and her relatives.
Topics: 3-Hydroxyacyl CoA Dehydrogenases; Adult; Carnitine; Cytosine; Family; Fatty Liver; Female; Guanine; Humans; Long-Chain-3-Hydroxyacyl-CoA Dehydrogenase; Mass Spectrometry; Mitochondrial Trifunctional Protein; Multienzyme Complexes; Mutation; Polymorphism, Restriction Fragment Length; Pregnancy; Pregnancy Complications; Protein Subunits; Sequence Analysis, DNA | 2007 |
[Application of tandem mass spectrometry on the diagnosis of fatty acid oxidation disorders].
Topics: Adolescent; Amino Acid Metabolism, Inborn Errors; Carnitine; Child; Child, Preschool; Female; Humans; Infant; Infant, Newborn; Lipid Metabolism; Lipid Metabolism, Inborn Errors; Male; Mass Spectrometry; Tandem Mass Spectrometry | 2007 |
Acylcarnitine profiles during carnitine loading and fasting tests in a Japanese patient with medium-chain acyl-CoA dehydrogenase deficiency.
Topics: Acyl-CoA Dehydrogenase; Asian People; Blood Glucose; Carnitine; Child; Child, Preschool; Diagnostic Tests, Routine; DNA Mutational Analysis; Fasting; Female; Humans; Japan; Lipid Metabolism, Inborn Errors | 2007 |
A new case of short-chain acyl-CoA dehydrogenase deficiency: clinical, biochemical, genetic and (1)H-NMR spectroscopic studies.
Topics: Adult; Butyryl-CoA Dehydrogenase; Carnitine; Chromatography, Gas; Humans; Magnetic Resonance Spectroscopy; Male; Metabolism, Inborn Errors | 2007 |
Interaction of mildronate with the mitochondrial carnitine/acylcarnitine transport protein.
Topics: Animals; Antiporters; Biological Transport; Carnitine; Dose-Response Relationship, Drug; Kinetics; Liposomes; Membrane Transport Proteins; Methylhydrazines; Mitochondria, Liver; Protein Binding; Rats; Time Factors | 2008 |
Metabolic testing in the pediatric epilepsy unit.
Topics: Adolescent; Adult; Amino Acids; Ammonia; Carnitine; Child; Child, Preschool; Electroencephalography; Epilepsy; Female; Follow-Up Studies; Humans; Infant; Magnetic Resonance Imaging; Male; Pediatrics; Retrospective Studies | 2008 |
Combined newborn screening for succinylacetone, amino acids, and acylcarnitines in dried blood spots.
Topics: Amino Acids; Blood Specimen Collection; Carnitine; Flow Injection Analysis; Heptanoates; Humans; Infant, Newborn; Neonatal Screening; Retrospective Studies; Tandem Mass Spectrometry; Tyrosinemias | 2008 |
Acylcarnitine profile analysis.
Topics: Biomarkers; Carnitine; Genes, Recessive; Genetics, Medical; Humans; Metabolism, Inborn Errors; Prevalence; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry | 2008 |
Carnitine supplementation induces acylcarnitine production in tissues of very long-chain acyl-CoA dehydrogenase-deficient mice, without replenishing low free carnitine.
Topics: Acyl-CoA Dehydrogenase, Long-Chain; Animals; Betaine; Carnitine; Cell Line, Tumor; Cell Proliferation; Cell Survival; Dietary Supplements; Humans; Lipid Metabolism, Inborn Errors; Liver; Mice; Mice, Knockout; Muscle, Skeletal; Palmitoyl Coenzyme A; Palmitoylcarnitine; Physical Exertion; Time Factors | 2008 |
Enhanced acyl-CoA dehydrogenase activity is associated with improved mitochondrial and contractile function in heart failure.
Topics: Acyl-CoA Dehydrogenase; Adiponectin; Animals; Blood Glucose; Carnitine; Dietary Fats; Disease Models, Animal; Electron Transport Chain Complex Proteins; Fatty Acids, Nonesterified; Heart Failure; Insulin; Leptin; Male; Mitochondria, Heart; Myocardial Contraction; Rats; Rats, Wistar; Triglycerides | 2008 |
Bioinformatics analysis of targeted metabolomics--uncovering old and new tales of diabetic mice under medication.
Topics: Amino Acids; Animals; Carnitine; Computational Biology; Diabetes Mellitus; Gluconeogenesis; Hypoglycemic Agents; Male; Mice; Mice, Inbred C57BL; Models, Biological; Rosiglitazone; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry; Thiazolidinediones | 2008 |
Enhancing newborn screening for tyrosinemia type I.
Topics: Amino Acids; Carnitine; Heptanoates; Humans; Infant, Newborn; Neonatal Screening; Tyrosinemias | 2008 |
Chronic suppression of acetyl-CoA carboxylase 1 in beta-cells impairs insulin secretion via inhibition of glucose rather than lipid metabolism.
Topics: Acetyl-CoA Carboxylase; Adenosine Diphosphate; Adenosine Triphosphate; Animals; Carnitine; Cell Line; Fatty Acids; Gene Expression Regulation, Enzymologic; Glucose; Insulin; Insulin Secretion; Insulin-Secreting Cells; Isoenzymes; Lipid Metabolism; Oxidation-Reduction; Pyruvic Acid; Rats; RNA, Small Interfering; Time Factors | 2008 |
Acquired multiple Acyl-CoA dehydrogenase deficiency in 10 horses with atypical myopathy.
Topics: Acyl-CoA Dehydrogenase; Acyl-CoA Dehydrogenases; Animals; Butyric Acid; Butyryl-CoA Dehydrogenase; Carnitine; Chromatography, High Pressure Liquid; Female; Gas Chromatography-Mass Spectrometry; Glutarates; Horse Diseases; Horses; Isovaleryl-CoA Dehydrogenase; Lactic Acid; Male; Microscopy, Electron; Microscopy, Fluorescence; Muscles; Muscular Diseases; Riboflavin | 2008 |
Impact of short- and medium-chain organic acids, acylcarnitines, and acyl-CoAs on mitochondrial energy metabolism.
Topics: Acids; Acyl Coenzyme A; Animals; Carnitine; Cattle; Electron Transport Complex III; Energy Metabolism; Humans; Mitochondria; Reye Syndrome | 2008 |
[New therapeutic approaches in mitochondrial fatty acid oxidation disorders].
Topics: Carnitine; Citric Acid Cycle; Fatty Acids; Humans; Mitochondrial Diseases; Mitochondrial Trifunctional Protein; Multienzyme Complexes | 2008 |
Identification of new mutations in the ETHE1 gene in a cohort of 14 patients presenting with ethylmalonic encephalopathy.
Topics: Adolescent; Amino Acid Sequence; Base Sequence; Brain Diseases, Metabolic, Inborn; Carnitine; Child; Child, Preschool; Cohort Studies; DNA; Female; Humans; Infant; Male; Mitochondrial Proteins; Models, Molecular; Molecular Sequence Data; Mutation, Missense; Nucleocytoplasmic Transport Proteins; Polymerase Chain Reaction; Polymorphism, Single Nucleotide; Sequence Alignment | 2008 |
Application of metabolomic principles to disorders of nucleotide metabolism reveals new metabolic perturbations.
Topics: Adenine Phosphoribosyltransferase; Adenosine Deaminase; Amino Acids; Carnitine; Dihydropyrimidine Dehydrogenase Deficiency; Dihydrouracil Dehydrogenase (NADP); Genetic Diseases, Inborn; Humans; Hypoxanthine Phosphoribosyltransferase; Metabolic Diseases; Ninhydrin; Nucleotides | 2008 |
[Neonatal onset of organic acidemia (propionic) diagnosed by tandem mass spectrometry].
Topics: Amino Acid Metabolism, Inborn Errors; Carnitine; Consanguinity; Fatal Outcome; Female; Humans; Infant, Newborn; Propionates; Tandem Mass Spectrometry | 2008 |
Determination of the reference range of endogenous plasma carnitines in healthy adults.
Topics: Acetylcarnitine; Adolescent; Adult; Age Factors; Blood Chemical Analysis; Carnitine; Chromatography, High Pressure Liquid; Female; Humans; Male; Reference Values; Sex Characteristics; Spectrometry, Mass, Electrospray Ionization; Young Adult | 2008 |
Urine acylcarnitine analysis by ESI-MS/MS: a new tool for the diagnosis of peroxisomal biogenesis disorders.
Topics: Carnitine; Female; Humans; Infant; Infant, Newborn; Male; Peroxisomal Disorders; Refsum Disease; Reproducibility of Results; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry; Zellweger Syndrome | 2008 |
Liquid chromatography/mass spectrometry determination of endogenous plasma acetyl and palmitoyl carnitines as potential biomarkers of beta-oxidation in mice.
Topics: Animals; Biomarkers; Calibration; Carnitine; Chromatography, Liquid; Isotope Labeling; Male; Mass Spectrometry; Mice; Mice, Inbred Strains; Molecular Structure; Oxidation-Reduction; Palmitoylcarnitine; Reference Standards; Reproducibility of Results; Sensitivity and Specificity | 2008 |
Carnitine-palmitoyltransferase 2 deficiency: novel mutations and relevance of newborn screening.
Topics: Carnitine; Carnitine O-Palmitoyltransferase; Child, Preschool; Humans; Infant, Newborn; Male; Mutation; Mutation, Missense; Neonatal Screening; Phenotype; Sequence Deletion | 2008 |
Muscle acylcarnitines during short-term fasting in lean healthy men.
Topics: Adult; Anthropometry; Blood Glucose; Calorimetry, Indirect; Carnitine; Fasting; Humans; Insulin Resistance; Lipid Metabolism; Male; Muscle, Skeletal; Oxidation-Reduction; Oxygen Consumption; Young Adult | 2009 |
Precursor ion scan profiles of acylcarnitines by atmospheric pressure thermal desorption chemical ionization tandem mass spectrometry.
Topics: Atmospheric Pressure; Carnitine; Humans; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry; Temperature | 2008 |
Plasma acylcarnitine and fatty acid profiles during exercise and training in Standardbreds.
Topics: 3-Hydroxybutyric Acid; Analysis of Variance; Animals; Carnitine; Fatty Acids; Gas Chromatography-Mass Spectrometry; Horses; Lactic Acid; Male; Muscle, Skeletal; Physical Conditioning, Animal | 2008 |
Corresponding increase in long-chain acyl-CoA and acylcarnitine after exercise in muscle from VLCAD mice.
Topics: Acyl Coenzyme A; Acyl-CoA Dehydrogenase, Long-Chain; Animals; Body Weight; Carnitine; Mice; Mice, Inbred C57BL; Mice, Knockout; Mitochondria, Muscle; Muscle, Skeletal; Physical Exertion | 2009 |
Proteomic changes associated with diabetes in the BB-DP rat.
Topics: Animals; Carnitine; Citrate (si)-Synthase; Diabetes Mellitus, Type 1; Disease Models, Animal; Electrophoresis, Gel, Two-Dimensional; Gluconeogenesis; Glycolysis; Liver; Male; Methionine; Muscle, Skeletal; Myocardium; Proteomics; Rats; Rats, Inbred BB; Reactive Oxygen Species | 2009 |
Challenges and developments in tandem mass spectrometry based clinical metabolomics.
Topics: Amino Acids; Biometry; Carnitine; Eicosanoids; Estradiol; Gas Chromatography-Mass Spectrometry; Humans; Infant, Newborn; Macrophages; Metabolome; Metabolomics; Neonatal Screening; Tandem Mass Spectrometry; Testosterone | 2009 |
Changes of the plasma metabolome during an oral glucose tolerance test: is there more than glucose to look at?
Topics: Bile Acids and Salts; Blood; Blood Chemical Analysis; Blood Glucose; Blood Proteins; Carnitine; Fatty Acids, Nonesterified; Glucose; Glucose Tolerance Test; Humans; Insulin; Lysophosphatidylcholines; Metabolome; Middle Aged | 2009 |
Newborn screening of inborn errors of metabolism by capillary electrophoresis-electrospray ionization-mass spectrometry: a second-tier method with improved specificity and sensitivity.
Topics: Adult; Amino Acids; Calibration; Carnitine; Electrophoresis, Capillary; Humans; Infant, Newborn; Mass Screening; Metabolism, Inborn Errors; Reproducibility of Results; Sensitivity and Specificity; Spectrometry, Mass, Electrospray Ionization | 2009 |
Bloodspot acylcarnitine and amino acid analysis in cord blood samples: efficacy and reference data from a large cohort study.
Topics: Amino Acids; Blood Chemical Analysis; Blood Specimen Collection; Carnitine; Cohort Studies; Efficiency; False Negative Reactions; Fetal Blood; Fetal Diseases; Humans; Infant, Newborn; Metabolic Diseases; Mothers; Neonatal Screening; Reference Values; Time Factors | 2009 |
Atypical presentation of VLCAD deficiency associated with a novel ACADVL splicing mutation.
Topics: Acyl-CoA Dehydrogenase, Long-Chain; Calcium Channel Blockers; Carnitine; DNA Mutational Analysis; Female; Humans; Lamotrigine; Lipid Metabolism, Inborn Errors; Muscle, Skeletal; Mutation; Succinate Dehydrogenase; Triazines; Young Adult | 2009 |
Serum metabolomics reveals irreversible inhibition of fatty acid beta-oxidation through the suppression of PPARalpha activation as a contributing mechanism of acetaminophen-induced hepatotoxicity.
Topics: Acetaminophen; Animals; Carnitine; Chemical and Drug Induced Liver Injury; Chromatography, Liquid; Cytochrome P-450 CYP2E1; Fatty Acids; Glutathione; Liver Diseases; Mass Spectrometry; Metabolomics; Mice; Mice, Knockout; PPAR alpha; Time Factors | 2009 |
Site-directed mutagenesis of the His residues of the rat mitochondrial carnitine/acylcarnitine carrier: implications for the role of His-29 in the transport pathway.
Topics: Amino Acid Sequence; Animals; Biological Transport; Carnitine; Carnitine Acyltransferases; Carrier Proteins; Escherichia coli; Histidine; Hydrogen-Ion Concentration; Kinetics; Mitochondrial Proteins; Models, Molecular; Molecular Sequence Data; Mutagenesis, Site-Directed; Rats; Recombinant Proteins; Sequence Alignment | 2009 |
Metabolomic profiling reveals distinct patterns of myocardial substrate use in humans with coronary artery disease or left ventricular dysfunction during surgical ischemia/reperfusion.
Topics: Aged; Anaerobic Threshold; Cardiac Output; Cardiopulmonary Bypass; Carnitine; Coronary Artery Disease; Female; Heart; Heart Arrest, Induced; Heart Diseases; Humans; Intraoperative Complications; Lactic Acid; Male; Metabolome; Middle Aged; Myocardial Reperfusion Injury; Myocardium; Postoperative Complications; Ventricular Dysfunction, Left | 2009 |
Stability of acylcarnitines and free carnitine in dried blood samples: implications for retrospective diagnosis of inborn errors of metabolism and neonatal screening for carnitine transporter deficiency.
Topics: Carnitine; Desiccation; Humans; Infant, Newborn; Linear Models; Metabolism, Inborn Errors; Neonatal Screening; Organic Cation Transport Proteins; Reproducibility of Results; Retrospective Studies; Solute Carrier Family 22 Member 5; Specimen Handling; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry; Temperature | 2009 |
Diagnostic assessment and long-term follow-up of 13 patients with Very Long-Chain Acyl-Coenzyme A dehydrogenase (VLCAD) deficiency.
Topics: Acyl-CoA Dehydrogenase, Long-Chain; Adolescent; Adult; Biomarkers; Carnitine; Cells, Cultured; Child; DNA Mutational Analysis; Exercise Tolerance; Female; Genetic Testing; Genotype; Heterozygote; Homozygote; Humans; Male; Metabolism, Inborn Errors; Middle Aged; Mitochondrial Diseases; Muscle Weakness; Muscular Diseases; Mutation; Rhabdomyolysis; Young Adult | 2009 |
Addition of formic acid improves acetonitrile extraction of dicarboxylic acylcarnitines.
Topics: Acetonitriles; Blood Chemical Analysis; Carnitine; Formates; Humans; Metabolic Diseases; Solvents | 2009 |
High heritability of metabolomic profiles in families burdened with premature cardiovascular disease.
Topics: Age of Onset; Amino Acids; Cardiovascular Diseases; Carnitine; Family Health; Fatty Acids; Female; Humans; Inheritance Patterns; Male; Metabolome; Middle Aged; Principal Component Analysis | 2009 |
Plasma acylcarnitine profiles suggest incomplete long-chain fatty acid beta-oxidation and altered tricarboxylic acid cycle activity in type 2 diabetic African-American women.
Topics: Adult; Aged; Aged, 80 and over; Black or African American; Carnitine; Citric Acid Cycle; Diabetes Mellitus, Type 2; Fatty Acids; Female; Humans; Ion Channels; Middle Aged; Mitochondrial Proteins; Mutation, Missense; NF-kappa B; Obesity; Oxidation-Reduction; Polymorphism, Genetic; Uncoupling Protein 3; Young Adult | 2009 |
Deuterated palmitate-driven acylcarnitine formation by whole-blood samples for a rapid diagnostic exploration of mitochondrial fatty acid oxidation disorders.
Topics: Acyl-CoA Dehydrogenases; Adult; Blood Specimen Collection; Carnitine; Case-Control Studies; Child; Child, Preschool; Deuterium; Fatty Acids; Female; Humans; Infant; Infant, Newborn; Kinetics; Male; Mitochondrial Diseases; Mutation; Oxidation-Reduction; Palmitates; Time Factors | 2009 |
Evidence for the participation of the stimulated sympathetic nervous system in the regulation of carnitine blood levels of soccer players during a game.
Topics: Adolescent; Antioxidants; Biomarkers; Carnitine; Chromatography, High Pressure Liquid; Creatine Kinase; Epinephrine; Humans; L-Lactate Dehydrogenase; Lactic Acid; Male; Norepinephrine; Pyruvic Acid; Soccer; Sympathetic Nervous System; Tandem Mass Spectrometry; Time Factors; Young Adult | 2009 |
Mitochondrial long chain fatty acid beta-oxidation in man and mouse.
Topics: Acyl-CoA Dehydrogenase, Long-Chain; Animals; Carnitine; Cell Line; Chromatography, High Pressure Liquid; Fatty Acids; Fibroblasts; Humans; Mice; Mitochondria; Oxidation-Reduction; Tandem Mass Spectrometry | 2009 |
Relationships between circulating metabolic intermediates and insulin action in overweight to obese, inactive men and women.
Topics: Adolescent; Adult; Aged; Amino Acids; Blood Glucose; Carnitine; Cross-Sectional Studies; Fatty Acids, Nonesterified; Female; Gas Chromatography-Mass Spectrometry; Humans; Insulin Resistance; Male; Middle Aged; Obesity; Overweight; Principal Component Analysis; Tandem Mass Spectrometry; Young Adult | 2009 |
Improved MS/MS analysis of succinylacetone extracted from dried blood spots when combined with amino acids and acylcarnitine butyl esters.
Topics: Amino Acids; Artifacts; Blood Chemical Analysis; Carnitine; Esters; Heptanoates; Humans; Hydrazines; Methanol; Specimen Handling; Tandem Mass Spectrometry | 2009 |
Carnitine insufficiency caused by aging and overnutrition compromises mitochondrial performance and metabolic control.
Topics: Aging; Animals; Biological Transport; Blotting, Western; Carnitine; Carnitine O-Acetyltransferase; Cells, Cultured; Dietary Fats; gamma-Butyrobetaine Dioxygenase; Glucose Intolerance; Glucose Tolerance Test; Humans; Lipid Metabolism; Male; Mitochondria, Muscle; Mixed Function Oxygenases; Overnutrition; Oxidative Phosphorylation; Random Allocation; Rats; Rats, Wistar; Reverse Transcriptase Polymerase Chain Reaction; Vitamin B Complex | 2009 |
Effect of heat stress and bezafibrate on mitochondrial beta-oxidation: comparison between cultured cells from normal and mitochondrial fatty acid oxidation disorder children using in vitro probe acylcarnitine profiling assay.
Topics: Acyl-CoA Dehydrogenase; Acyl-CoA Dehydrogenase, Long-Chain; Bezafibrate; Carnitine; Cells, Cultured; Child; Fatty Acids; Fibroblasts; Hot Temperature; Humans; Hypolipidemic Agents; Lipid Metabolism, Inborn Errors; Mitochondria; Mitochondrial Diseases; Oxidation-Reduction; Stress, Physiological | 2010 |
[Multiple acyl-CoA dehydrogenase deficiency (MADD): a curable cause of genetic muscular lipidosis].
Topics: Acyl-CoA Dehydrogenases; Adult; Biopsy; Brain Diseases, Metabolic; Carnitine; Coloring Agents; DNA Mutational Analysis; Electron Transport; Electron-Transferring Flavoproteins; Female; Humans; Lipid Metabolism, Inborn Errors; Lipidoses; Male; Middle Aged; Muscle Weakness; Muscle, Skeletal; Riboflavin; Tandem Mass Spectrometry; Young Adult | 2010 |
Statins, fibrates and retinoic acid upregulate mitochondrial acylcarnitine carrier gene expression.
Topics: Alitretinoin; Animals; Anticholesteremic Agents; Carnitine; Clofibric Acid; Colforsin; Gene Expression; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Membrane Transport Proteins; Mitochondria; PPAR alpha; Promoter Regions, Genetic; Rats; Tretinoin | 2009 |
A neonatal death due to medium-chain acyl-CoA dehydrogenase deficiency: utilization of the neonatal metabolic screen in a functional approach to sudden unexplained infant death.
Topics: Acyl-CoA Dehydrogenase; Carnitine; Gene Deletion; Humans; Infant, Newborn; Lipid Metabolism, Inborn Errors; Male; Neonatal Screening; Point Mutation; Sudden Infant Death | 2009 |
Searching for the needle in the Haystacks.
Topics: Acyl-CoA Dehydrogenase, Long-Chain; Age of Onset; Biopsy; Carnitine; Creatine Kinase; Creatinine; Histocytochemistry; Humans; Male; Middle Aged; Mitochondrial Myopathies; Prognosis; Rare Diseases; Recurrence; Rhabdomyolysis; Walking | 2009 |
Dissection of biochemical borderline phenotypes in carriers and genetic variants of medium-chain acyl-CoA dehyrogenase deficiency: implications for newborn screening [corrected].
Topics: Carnitine; Case-Control Studies; Heterozygote; Humans; Infant, Newborn; Lipid Metabolism, Inborn Errors; Mutation; Neonatal Screening | 2009 |
Variation in the human lipidome associated with coffee consumption as revealed by quantitative targeted metabolomics.
Topics: Aged; Atherosclerosis; Carnitine; Cholesterol; Coffee; Humans; Male; Metabolomics; Middle Aged; Sphingomyelins; Tandem Mass Spectrometry | 2009 |
Identification of a neonate with hepatorenal tyrosinemia by combined routine newborn screening for succinylacetone, acylcarnitines and amino acids.
Topics: Amino Acids; Carnitine; Heptanoates; Humans; Infant, Newborn; Kidney Diseases; Liver Diseases; Neonatal Screening; Tandem Mass Spectrometry; Tyrosinemias | 2010 |
Newborn screening and early biochemical follow-up in combined methylmalonic aciduria and homocystinuria, cblC type, and utility of methionine as a secondary screening analyte.
Topics: Algorithms; Carnitine; Demography; False Positive Reactions; Female; Follow-Up Studies; Genetic Association Studies; Homocystinuria; Humans; Infant, Newborn; Male; Metabolism, Inborn Errors; Methionine; Methylmalonic Acid; Neonatal Screening; New York; Propionates; Referral and Consultation; Vitamin B 12 | 2010 |
Relationship between plasma free fatty acid, intramyocellular triglycerides and long-chain acylcarnitines in resting humans.
Topics: Adult; Carnitine; Fatty Acids, Nonesterified; Female; Humans; Male; Muscle Fibers, Skeletal; Rest; Triglycerides | 2009 |
Two novel HADHB gene mutations in a Korean patient with mitochondrial trifunctional protein deficiency.
Topics: 3-Hydroxyacyl CoA Dehydrogenases; Cardiomyopathies; Carnitine; DNA Mutational Analysis; Humans; Infant, Newborn; Lipid Metabolism, Inborn Errors; Male; Mitochondria; Mitochondrial Myopathies; Mitochondrial Proteins; Mitochondrial Trifunctional Protein; Mitochondrial Trifunctional Protein, beta Subunit; Multienzyme Complexes; Mutation; Nervous System Diseases; Peripheral Nervous System Diseases; Republic of Korea; Retinitis Pigmentosa; Rhabdomyolysis | 2009 |
Mechanisms underlying metabolic and neural defects in zebrafish and human multiple acyl-CoA dehydrogenase deficiency (MADD).
Topics: Animals; Carboxylic Acids; Carnitine; Cell Proliferation; Cloning, Molecular; Electron-Transferring Flavoproteins; Enzyme Activation; Extracellular Signal-Regulated MAP Kinases; Fibroblasts; Glycolysis; Humans; Infant; Infant, Newborn; Iron-Sulfur Proteins; Mitochondria; Multiple Acyl Coenzyme A Dehydrogenase Deficiency; Mutation; Nervous System; Neurons; Oligonucleotides, Antisense; Oxidoreductases Acting on CH-NH Group Donors; Peroxisome Proliferator-Activated Receptors; Phenotype; Zebrafish | 2009 |
Diagnosis, treatment, and long-term outcomes of late-onset (type III) multiple acyl-CoA dehydrogenase deficiency.
Topics: Brain Diseases, Metabolic; Carnitine; Child; Child, Preschool; Developmental Disabilities; Female; Humans; Male; Mass Screening; Metabolic Diseases; Multiple Acyl Coenzyme A Dehydrogenase Deficiency | 2010 |
Increased mitochondrial content rescues in vivo muscle oxidative capacity in long-term high-fat-diet-fed rats.
Topics: Animals; Carnitine; Diet; Dietary Fats; Insulin Resistance; Male; Mitochondria, Muscle; Muscle, Skeletal; Oxidation-Reduction; Oxygen Consumption; Rats; Rats, Wistar | 2010 |
Study of inborn errors of metabolism in urine from patients with unexplained mental retardation.
Topics: Adenylosuccinate Lyase; Adolescent; Adult; Aged; Carnitine; Child; Child, Preschool; Chromium; Cohort Studies; Creatine; Female; Humans; Intellectual Disability; Male; Metabolism, Inborn Errors; Middle Aged; Phenylketonurias; Purines; Pyrimidines | 2010 |
Acylcarnitine analysis by tandem mass spectrometry.
Topics: Carnitine; Flow Injection Analysis; Humans; Lipid Metabolism, Inborn Errors; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry | 2010 |
Preeclampsia and HELLP syndrome: impaired mitochondrial function in umbilical endothelial cells.
Topics: Adult; Carnitine; Carnitine O-Palmitoyltransferase; Citrate (si)-Synthase; Electron Transport; Endothelial Cells; Energy Metabolism; Fatty Acids; Female; Glycolysis; HELLP Syndrome; Humans; Infant, Newborn; L-Lactate Dehydrogenase; Mitochondria; Mitochondrial Diseases; Multienzyme Complexes; Oxidation-Reduction; Phosphofructokinases; Pre-Eclampsia; Pregnancy; Umbilical Veins | 2010 |
Cardiac and plasma lipid profiles in response to acute hypoxia in neonatal and young adult rats.
Topics: Animals; Carnitine; Dietary Fats; Fatty Acids; Female; Hypoxia; Lipids; Male; Models, Biological; Myocardium; Rats; Rats, Sprague-Dawley; Time Factors | 2010 |
Measurement of plasma/serum acylcarnitines using tandem mass spectrometry.
Topics: Carnitine; Humans; Lipid Metabolism, Inborn Errors; Pediatrics; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry | 2010 |
Comparison of amino acids and acylcarnitines assay methods used in newborn screening assays by tandem mass spectrometry.
Topics: Amino Acids; Butanols; Carnitine; Humans; Infant, Newborn; Leucine; Metabolic Diseases; Methionine; Neonatal Screening; Palmitoylcarnitine; Phenylalanine; Quality Control; Tandem Mass Spectrometry | 2010 |
LMNA mutations, skeletal muscle lipid metabolism, and insulin resistance.
Topics: Adult; Blood Glucose; Carnitine; Cells, Cultured; Energy Metabolism; Female; Glycogen; Humans; Insulin; Insulin Resistance; Lamin Type A; Lipid Metabolism; Lipodystrophy, Familial Partial; Male; Middle Aged; Muscle Fibers, Skeletal; Muscle, Skeletal; Muscular Dystrophies, Limb-Girdle; Mutation; Oligonucleotide Array Sequence Analysis; Oxidation-Reduction; Phenotype | 2010 |
The first case of mitochondrial acetoacetyl-CoA thiolase deficiency identified by expanded newborn metabolic screening in Italy: the importance of an integrated diagnostic approach.
Topics: Acetyl-CoA C-Acetyltransferase; Acetyl-CoA C-Acyltransferase; Amino Acid Metabolism, Inborn Errors; Biomarkers; Carnitine; Chromatography, Liquid; DNA Mutational Analysis; Dried Blood Spot Testing; Genetic Predisposition to Disease; Genetic Testing; Heredity; Humans; Infant, Newborn; Italy; Mutation; Neonatal Screening; Pedigree; Phenotype; Predictive Value of Tests; Tandem Mass Spectrometry | 2010 |
Serum carnitine levels in childhood leukemia.
Topics: Acute Disease; Adolescent; Body Mass Index; Carnitine; Child; Child, Preschool; Female; Humans; Leukemia; Male; Muscle, Skeletal | 2010 |
Four years of expanded newborn screening in Portugal with tandem mass spectrometry.
Topics: Amino Acids; Biomarkers; Carnitine; Early Diagnosis; False Positive Reactions; Genetic Predisposition to Disease; Humans; Infant, Newborn; Metabolism, Inborn Errors; Neonatal Screening; Phenotype; Portugal; Predictive Value of Tests; Prevalence; Prognosis; Program Evaluation; Tandem Mass Spectrometry; Time Factors | 2010 |
SIRT3 regulates mitochondrial fatty-acid oxidation by reversible enzyme deacetylation.
Topics: Acetylation; Acyl-CoA Dehydrogenase, Long-Chain; Adenosine Triphosphate; Adipose Tissue, Brown; Animals; Body Temperature Regulation; Caloric Restriction; Carnitine; Cell Line; Cold Temperature; Fasting; Fatty Acids; Humans; Hypoglycemia; Liver; Male; Mass Spectrometry; Mice; Mitochondria; Oxidation-Reduction; Sirtuin 3; Triglycerides; Up-Regulation | 2010 |
Heat stress deteriorates mitochondrial beta-oxidation of long-chain fatty acids in cultured fibroblasts with fatty acid beta-oxidation disorders.
Topics: Adolescent; Carnitine; Child; Fatty Acids; Female; Fibroblasts; Heat Stress Disorders; Humans; Lipid Metabolism, Inborn Errors; Male; Mitochondria; Oxidation-Reduction; Tandem Mass Spectrometry | 2010 |
Metabolomic analyses of plasma reveals new insights into asphyxia and resuscitation in pigs.
Topics: Animals; Animals, Newborn; Asphyxia; Blood Proteins; Carnitine; Female; Glycine; Hydrogen-Ion Concentration; Hypoxia; Lactates; Male; Metabolomics; Oxygen; Resuscitation; Swine | 2010 |
Hypoketotic hypoglycemia with myolysis and hypoparathyroidism: an unusual association in medium chain acyl-CoA desydrogenase deficiency (MCADD).
Topics: Acute Kidney Injury; Acyl-CoA Dehydrogenase; Carnitine; Child, Preschool; Female; Glucose; Humans; Hypoglycemia; Hypoparathyroidism; Ketones; Lipid Metabolism, Inborn Errors; Mutation, Missense; Vitamin B Complex | 2009 |
Elevated hydroxyacylcarnitines in a carrier of LCHAD deficiency during acute liver disease of pregnancy - a common feature of the pregnancy complication?
Topics: 3-Hydroxyacyl CoA Dehydrogenases; Acute Disease; Adult; Carnitine; Fatty Liver; Female; Humans; Lipid Metabolism, Inborn Errors; Liver Diseases; Long-Chain-3-Hydroxyacyl-CoA Dehydrogenase; Mitochondrial Trifunctional Protein; Multienzyme Complexes; Pregnancy; Pregnancy Complications; Pregnancy Trimester, Third | 2010 |
In vitro probe acylcarnitine profiling assay using cultured fibroblasts and electrospray ionization tandem mass spectrometry predicts severity of patients with glutaric aciduria type 2.
Topics: Carnitine; Case-Control Studies; Cells, Cultured; Fibroblasts; Humans; Molecular Structure; Multiple Acyl Coenzyme A Dehydrogenase Deficiency; Spectrometry, Mass, Electrospray Ionization | 2010 |
Altered brain phospholipid and acylcarnitine profiles in propionic acid infused rodents: further development of a potential model of autism spectrum disorders.
Topics: Animals; Behavior, Animal; Brain; Carnitine; Child; Child Development Disorders, Pervasive; Chromatography, Thin Layer; Disease Models, Animal; Gas Chromatography-Mass Spectrometry; Humans; Injections, Intraventricular; Male; Motor Activity; Phospholipids; Propionates; Rats; Rats, Long-Evans; Spectrometry, Mass, Electrospray Ionization; Stereotyped Behavior | 2010 |
Useful second-tier tests in expanded newborn screening of isovaleric acidemia and methylmalonic aciduria.
Topics: Amino Acid Metabolism, Inborn Errors; Biomarkers; Blood Specimen Collection; Carnitine; Case-Control Studies; Chromatography, Liquid; False Positive Reactions; Gas Chromatography-Mass Spectrometry; Glycine; Humans; Infant, Newborn; Isovaleryl-CoA Dehydrogenase; Japan; Lactic Acid; Metabolism, Inborn Errors; Methylmalonic Acid; Neonatal Screening; Pilot Projects; Predictive Value of Tests; Retrospective Studies; Severity of Illness Index; Tandem Mass Spectrometry | 2010 |
Pre-exercise medium-chain triglyceride application prevents acylcarnitine accumulation in skeletal muscle from very-long-chain acyl-CoA-dehydrogenase-deficient mice.
Topics: Acyl Coenzyme A; Acyl-CoA Dehydrogenase, Long-Chain; Animal Feed; Animals; Carnitine; Lipids; Mice; Mice, Knockout; Muscle, Skeletal; Oxazines; Oxygen; Physical Conditioning, Animal; Triglycerides | 2010 |
Atypical antipsychotics rapidly and inappropriately switch peripheral fuel utilization to lipids, impairing metabolic flexibility in rodents.
Topics: Animals; Antipsychotic Agents; Benzodiazepines; Carnitine; Clozapine; Energy Metabolism; Fatty Acids, Nonesterified; Female; Haloperidol; Insulin Resistance; Lipolysis; Male; Malonyl Coenzyme A; Mice; Olanzapine; Piperazines; Rats; Rats, Sprague-Dawley; Risperidone; Thiazoles; Vitamin B Complex | 2012 |
Metabolic profiling of muscle contraction in lean compared with obese rodents.
Topics: Acetyl-CoA Carboxylase; Animals; Biological Transport; Carnitine; Glucose; Glycogen; Lactic Acid; Lipids; Malonyl Coenzyme A; Muscle Contraction; Muscle, Skeletal; Obesity; Pyruvic Acid; Rats; Rats, Zucker; Sciatic Nerve; Triglycerides | 2010 |
Carnitine palmitoyltransferase 2: New insights on the substrate specificity and implications for acylcarnitine profiling.
Topics: Acyl Coenzyme A; Carnitine; Carnitine O-Palmitoyltransferase; Catalysis; Humans; Kinetics; Metabolome; Organisms, Genetically Modified; Osmolar Concentration; Saccharomyces cerevisiae; Substrate Specificity | 2010 |
Carnitine palmitoyltransferase 2 deficiency: the time-course of blood and urinary acylcarnitine levels during initial L-carnitine supplementation.
Topics: Acetylcarnitine; Amino Acid Metabolism, Inborn Errors; Amino Acids; Blood Chemical Analysis; Carnitine; Carnitine O-Palmitoyltransferase; Child, Preschool; Female; Follow-Up Studies; Humans; Infant; Lipid Metabolism, Inborn Errors; Reye Syndrome; Time Factors; Treatment Outcome; Vitamin B Complex | 2010 |
Tandem mass spectrometry screening for very long-chain acyl-CoA dehydrogenase deficiency: the value of second-tier enzyme testing.
Topics: Acyl-CoA Dehydrogenase, Long-Chain; Carnitine; Clinical Enzyme Tests; Humans; Infant, Newborn; Metabolism, Inborn Errors; Neonatal Screening; Tandem Mass Spectrometry | 2010 |
Rapid determination of C4-acylcarnitine and C5-acylcarnitine isomers in plasma and dried blood spots by UPLC-MS/MS as a second tier test following flow-injection MS/MS acylcarnitine profile analysis.
Topics: Carnitine; Chromatography, Liquid; Humans; Infant, Newborn; Isomerism; Neonatal Screening; Tandem Mass Spectrometry | 2010 |
The effects of long- or medium-chain fat diets on glucose tolerance and myocellular content of lipid intermediates in rats.
Topics: Analysis of Variance; Animals; Blood Glucose; Blotting, Western; Body Weight; Carnitine; Dietary Fats; Diglycerides; Energy Metabolism; Fatty Acids; Glucose Intolerance; Glucose Tolerance Test; Insulin; Insulin Resistance; Lipid Peroxidation; Male; Muscle, Skeletal; Rats; Rats, Wistar; Triglycerides | 2011 |
Postprandial changes of amino acid and acylcarnitine concentrations in dried blood samples.
Topics: Adult; Amino Acids; Biomarkers; Blood Specimen Collection; Carnitine; False Negative Reactions; False Positive Reactions; Humans; Infant, Newborn; Metabolism, Inborn Errors; Middle Aged; Neonatal Screening; Postprandial Period; Predictive Value of Tests; Up-Regulation; Young Adult | 2010 |
Post-mortem MRI reveals CPT2 deficiency after sudden infant death.
Topics: Carnitine; Carnitine O-Palmitoyltransferase; Cause of Death; Diagnosis; Fatty Liver; Hepatomegaly; Humans; Infant; Magnetic Resonance Imaging; Male; Metabolism, Inborn Errors; Postmortem Changes; Sudden Infant Death | 2010 |
Clinical and biochemical improvement of very long-chain acyl-CoA dehydrogenase deficiency in pregnancy.
Topics: Acyl-CoA Dehydrogenase, Long-Chain; Carnitine; Female; Humans; Infant, Newborn; Lipid Metabolism, Inborn Errors; Male; Pregnancy; Pregnancy Complications; Prenatal Care; Rhabdomyolysis; Term Birth; Young Adult | 2010 |
Global analysis of circulating metabolites in hibernating ground squirrels.
Topics: Animals; Carnitine; Cholesterol Esters; Chromatography, Liquid; Female; Hibernation; Lysophospholipids; Male; Mass Spectrometry; Metabolomics; Sciuridae; Seasons; Sphingosine | 2010 |
Genotype-phenotype correlations in a large series of patients with muscle type CPT II deficiency.
Topics: Adolescent; Adult; Carnitine; Carnitine O-Palmitoyltransferase; Child; Child, Preschool; Female; Genetic Association Studies; Humans; Male; Metabolism, Inborn Errors; Middle Aged; Muscle, Skeletal; Mutation | 2011 |
Urgent metabolic service improves survival in long-chain 3-hydroxyacyl-CoA dehydrogenase (LCHAD) deficiency detected by symptomatic identification and pilot newborn screening.
Topics: 3-Hydroxyacyl CoA Dehydrogenases; Adolescent; Carnitine; Child; Child, Preschool; Cohort Studies; Desiccation; DNA Mutational Analysis; Emergency Service, Hospital; Female; Gas Chromatography-Mass Spectrometry; Humans; Infant; Infant, Newborn; Intensive Care Units, Neonatal; Long-Chain-3-Hydroxyacyl-CoA Dehydrogenase; Male; Metabolism, Inborn Errors; Neonatal Screening; Physical Examination; Pilot Projects; Polymorphism, Restriction Fragment Length; Survival; Time Factors; Urinalysis | 2011 |
Role of FOXA and Sp1 in mitochondrial acylcarnitine carrier gene expression in different cell lines.
Topics: Binding Sites; Carnitine; Gene Expression Regulation, Enzymologic; HEK293 Cells; Hepatocyte Nuclear Factor 3-alpha; Humans; Membrane Transport Proteins; Mitochondria; Mutation; Promoter Regions, Genetic; Sp1 Transcription Factor; Transcription, Genetic | 2011 |
A high-fat diet elicits differential responses in genes coordinating oxidative metabolism in skeletal muscle of lean and obese individuals.
Topics: Adolescent; Adult; Blood Glucose; Body Mass Index; Carnitine; Diet; Dietary Fats; Fatty Acids, Nonesterified; Female; Gene Expression Regulation; Humans; Insulin; Ion Channels; Lipid Metabolism; Male; Mitochondrial Proteins; Muscle, Skeletal; Obesity; Oxidation-Reduction; PPAR alpha; Pyruvate Dehydrogenase (Lipoamide); RNA, Messenger; Spectrometry, Mass, Electrospray Ionization; Uncoupling Protein 3; Young Adult | 2011 |
Evaluation of valproate effects on acylcarnitine in epileptic children by LC-MS/MS.
Topics: Adolescent; Anticonvulsants; Carnitine; Child; Child, Preschool; Chromatography, Liquid; Epilepsy; Female; Humans; Infant; Linear Models; Longitudinal Studies; Male; Statistics, Nonparametric; Tandem Mass Spectrometry; Valproic Acid | 2011 |
Long-chain acylcarnitine deficiency in patients with chronic fatigue syndrome. Potential involvement of altered carnitine palmitoyltransferase-I activity.
Topics: Adult; Aged; Carnitine; Carnitine O-Palmitoyltransferase; Epidemiologic Methods; Fatigue Syndrome, Chronic; Female; Humans; Male; Middle Aged | 2011 |
Acylcarnitines: analysis in plasma and whole blood using tandem mass spectrometry.
Topics: Analytic Sample Preparation Methods; Blood Chemical Analysis; Blood Specimen Collection; Carnitine; Esters; Filtration; Humans; Paper; Plasma; Reference Standards; Reproducibility of Results; Tandem Mass Spectrometry; Time Factors | 2011 |
[Blood spot carnitine and acylcarnitine in newborn to adolescence: measured by tandem mass spectrometry].
Topics: Adolescent; Carnitine; Child; Child, Preschool; Female; Humans; Infant; Infant, Newborn; Male; Tandem Mass Spectrometry | 2010 |
Improved tandem mass spectrometry (MS/MS) derivatized method for the detection of tyrosinemia type I, amino acids and acylcarnitine disorders using a single extraction process.
Topics: Amino Acids; Carnitine; Chemical Fractionation; Cost-Benefit Analysis; Heptanoates; Humans; Hydrazones; Infant, Newborn; Tandem Mass Spectrometry; Time Factors; Tyrosinemias | 2011 |
Retrospective review of Japanese sudden unexpected death in infancy: the importance of metabolic autopsy and expanded newborn screening.
Topics: Acyl-CoA Dehydrogenase, Long-Chain; Carnitine; Carnitine Acyltransferases; Carnitine O-Palmitoyltransferase; Case-Control Studies; Female; Haplotypes; Humans; Infant; Infant, Newborn; Japan; Liver; Male; Mitochondrial Trifunctional Protein; Multienzyme Complexes; Mutation, Missense; Neonatal Screening; Retrospective Studies; Sudden Infant Death | 2011 |
Clinical, biochemical and genetic analyses in two Korean patients with medium-chain acyl-CoA dehydrogenase deficiency.
Topics: Acyl-CoA Dehydrogenase; Asian People; Base Sequence; Biomarkers; Carnitine; DNA Mutational Analysis; Exons; Female; Gene Deletion; Heterozygote; Humans; Infant, Newborn; Lipid Metabolism, Inborn Errors; Male; Mutation; Neonatal Screening; Republic of Korea; Tandem Mass Spectrometry | 2011 |
Bioactives from bitter melon enhance insulin signaling and modulate acyl carnitine content in skeletal muscle in high-fat diet-fed mice.
Topics: Animals; Carnitine; Cells, Cultured; Diet, High-Fat; Glucose; Insulin; Male; Mice; Momordica charantia; Muscle Fibers, Skeletal; Muscle, Skeletal; Plant Extracts; Signal Transduction | 2011 |
Mutations of ACADS gene associated with short-chain acyl-coenzyme A dehydrogenase deficiency.
Topics: Acyl-CoA Dehydrogenase; Base Sequence; Carnitine; DNA Mutational Analysis; Female; Genetic Predisposition to Disease; Homozygote; Humans; Infant, Newborn; Lipid Metabolism, Inborn Errors; Molecular Sequence Data; Mutation | 2011 |
Clinical validation of cutoff target ranges in newborn screening of metabolic disorders by tandem mass spectrometry: a worldwide collaborative project.
Topics: Amino Acids; Carnitine; Humans; Infant, Newborn; International Cooperation; Metabolic Diseases; Neonatal Screening; Reference Values; Sensitivity and Specificity; Software; Tandem Mass Spectrometry | 2011 |
Carnitine and coenzyme Q10 levels in individuals with Prader-Willi syndrome.
Topics: Carnitine; Case-Control Studies; Child; Female; Humans; Male; Prader-Willi Syndrome; Siblings; Ubiquinone | 2011 |
Ultra-high performance liquid chromatography tandem mass spectrometry for comprehensive analysis of urinary acylcarnitines.
Topics: Adult; Carnitine; Chromatography, High Pressure Liquid; Humans; Lipid Metabolism; Metabolomics; Microsomes, Liver; Solid Phase Extraction; Tandem Mass Spectrometry; Young Adult | 2011 |
Abnormally low serum acylcarnitine levels in narcolepsy patients.
Topics: Adult; Carnitine; Carnitine O-Palmitoyltransferase; Case-Control Studies; Female; Gene Expression; Genotype; Humans; Male; Middle Aged; Narcolepsy; Polymorphism, Single Nucleotide; Reverse Transcriptase Polymerase Chain Reaction | 2011 |
Plasma acylcarnitines are associated with physical performance in elderly men.
Topics: Aged; Carnitine; Gait; Hand Strength; Humans; Male; Mass Spectrometry; Motor Activity; Overweight | 2011 |
Positive newborn screen in a normal infant of a mother with asymptomatic very long-chain Acyl-CoA dehydrogenase deficiency.
Topics: Acyl-CoA Dehydrogenase, Long-Chain; Carnitine; Congenital Bone Marrow Failure Syndromes; Female; Genotype; Humans; Infant, Newborn; Lipid Metabolism, Inborn Errors; Male; Metabolism, Inborn Errors; Mitochondrial Diseases; Mothers; Muscular Diseases; Neonatal Screening; Phenotype | 2011 |
Capillary electrophoresis with contactless conductivity detection for the determination of carnitine and acylcarnitines in clinical samples.
Topics: Carnitine; Electric Conductivity; Electrophoresis, Capillary; Humans; Hydrogen-Ion Concentration; Linear Models; Reproducibility of Results; Sensitivity and Specificity; Solid Phase Extraction | 2011 |
Postnatal variations in blood free and acylcarnitines.
Topics: Carnitine; Female; Genetic Variation; Gestational Age; Humans; Infant, Newborn; Male; Metabolism, Inborn Errors; Neonatal Screening; Reference Values; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry | 2011 |
Analysis of inborn errors of metabolism: disease spectrum for expanded newborn screening in Hong Kong.
Topics: Acids; Amino Acids; Carnitine; Hong Kong; Humans; Infant, Newborn; Metabolism, Inborn Errors; Neonatal Screening; Tandem Mass Spectrometry | 2011 |
Metabolic remodeling of human skeletal myocytes by cocultured adipocytes depends on the lipolytic state of the system.
Topics: Adipocytes; Carnitine; Coculture Techniques; Fatty Acids, Nonesterified; Female; Gene Expression; Glucose; Humans; Insulin; Insulin Resistance; Lipolysis; Muscle Fibers, Skeletal; Obesity; Thinness; Triglycerides | 2011 |
Expanded molecular features of carnitine acyl-carnitine translocase (CACT) deficiency by comprehensive molecular analysis.
Topics: Adult; Base Sequence; Carnitine; Carnitine Acyltransferases; Child, Preschool; Comparative Genomic Hybridization; Exons; Female; Humans; Infant; Male; Membrane Transport Proteins; Molecular Sequence Data; Mutation | 2011 |
Fatal viral infection-associated encephalopathy in two Chinese boys: a genetically determined risk factor of thermolabile carnitine palmitoyltransferase II variants.
Topics: Amino Acid Substitution; Base Sequence; Carnitine; Carnitine O-Palmitoyltransferase; Child, Preschool; DNA Mutational Analysis; Encephalitis, Viral; Enzyme Stability; Family Health; Fatal Outcome; Female; Genetic Predisposition to Disease; Genotype; Humans; Influenza, Human; Male; Molecular Sequence Data; Mutation; Pedigree; Risk Factors; Temperature | 2011 |
Urinary acylcarnitines are altered in human kidney cancer.
Topics: Animals; Biomarkers, Tumor; Carnitine; Cell Line, Tumor; Humans; Kidney; Kidney Neoplasms; Metabolomics; Mice; Neoplasm Grading; Neoplasm Transplantation; NF-kappa B; Transplantation, Heterologous | 2012 |
Altered carnitine metabolism in dialysis patients with reduced physical function may be due to dysfunctional fatty acid oxidation.
Topics: Activities of Daily Living; Aged; Anemia; Carnitine; Cross-Sectional Studies; Erythrocytes; Erythropoietin; Fatty Acids; Female; Follow-Up Studies; Humans; Lipid Metabolism; Male; Oxidation-Reduction; Prognosis; Quality of Life; Renal Dialysis | 2012 |
Rare magnetic resonance imaging findings in medium-chain acyl-coenzyme A dehydrogenase deficiency.
Topics: Acyl-CoA Dehydrogenase; Anticonvulsants; Basal Ganglia; Brain; Brain Ischemia; Carnitine; Cerebral Infarction; Child, Preschool; Glasgow Coma Scale; Humans; Lipid Metabolism, Inborn Errors; Liver Function Tests; Magnetic Resonance Imaging; Male; Respiration, Artificial; Seizures; Valproic Acid | 2011 |
Discovery of sexual dimorphisms in metabolic and genetic biomarkers.
Topics: Adult; Aged; Aged, 80 and over; Amino Acids; Carnitine; Female; Genetic Markers; Genome-Wide Association Study; Glycine; Humans; Lipids; Male; Metabolome; Middle Aged; Polymorphism, Single Nucleotide; Sex Characteristics | 2011 |
Tandem mass spectrometry findings at autopsy for detection of metabolic disease in infant deaths: postmortem changes and confounding factors.
Topics: Autopsy; Bile; Carnitine; Humans; Infant; Infant, Newborn; Liver; Metabolic Diseases; Organ Size; Postmortem Changes; Sudden Infant Death; Tandem Mass Spectrometry | 2011 |
Cardiac involvement in inflammatory bowel disease: role of acylcarnitine esters.
Topics: Adult; Cardiomyopathy, Dilated; Carnitine; Case-Control Studies; Female; Heart Ventricles; Humans; Inflammatory Bowel Diseases; Malabsorption Syndromes; Male; Middle Aged; Myocardium; Ultrasonography; Young Adult | 2011 |
Severe dysfunction of respiratory chain and cholesterol metabolism in Atp7b(-/-) mice as a model for Wilson disease.
Topics: Aconitate Hydratase; Adenosine Triphosphatases; Alanine; Animals; Brain; Carnitine; Cation Transport Proteins; Cholesterol; Copper; Copper-Transporting ATPases; Disease Models, Animal; Electron Transport; Electron Transport Chain Complex Proteins; Gene Knockout Techniques; Glutathione; Hepatolenticular Degeneration; Humans; Liver; Mice; Mice, 129 Strain; Mice, Knockout; Mitochondria; Oxidative Stress; Superoxide Dismutase | 2011 |
Hepatic and muscular effects of different dietary fat content in VLCAD deficient mice.
Topics: Acyl-CoA Dehydrogenase, Long-Chain; Animals; Carnitine; Congenital Bone Marrow Failure Syndromes; Diet; Dietary Fats; Energy Metabolism; Glycogen; Lipid Metabolism; Lipid Metabolism, Inborn Errors; Lipids; Lipogenesis; Liver; Mice; Mice, 129 Strain; Mice, Inbred C57BL; Mice, Knockout; Mitochondrial Diseases; Muscle, Skeletal; Muscular Diseases; Physical Exertion; Up-Regulation | 2011 |
An improved LC-MS/MS method for the detection of classic and low excretor glutaric acidemia type 1.
Topics: Amino Acid Metabolism, Inborn Errors; Brain Diseases, Metabolic; Carnitine; Case-Control Studies; Chromatography, Liquid; Follow-Up Studies; Glutaryl-CoA Dehydrogenase; Humans; Ions; Predictive Value of Tests; Reproducibility of Results; Tandem Mass Spectrometry | 2012 |
Analysis of plasma ghrelin in patients with medium-chain acyl-CoA dehydrogenase deficiency and glutaric aciduria type II.
Topics: Acyl-CoA Dehydrogenase; Adult; Blood Chemical Analysis; Carnitine; Case-Control Studies; Child; Child, Preschool; Chromatography, High Pressure Liquid; Female; Ghrelin; Humans; Lipid Metabolism, Inborn Errors; Multiple Acyl Coenzyme A Dehydrogenase Deficiency; Protein Processing, Post-Translational; Young Adult | 2012 |
Bile acid sequestration reduces plasma glucose levels in db/db mice by increasing its metabolic clearance rate.
Topics: Animals; Bile Acids and Salts; Blood Glucose; Carbon Isotopes; Carnitine; Diabetes Mellitus, Experimental; Glucose; Liver; Metabolic Clearance Rate; Mice; Mice, Knockout; Muscle, Skeletal | 2011 |
Combined extraction of acyl carnitines and 26:0 lysophosphatidylcholine from dried blood spots: prospective newborn screening for X-linked adrenoleukodystrophy.
Topics: Adrenoleukodystrophy; Carnitine; Chromatography, Liquid; Dried Blood Spot Testing; Humans; Infant, Newborn; Lysophosphatidylcholines; Mass Spectrometry; Molecular Diagnostic Techniques; Neonatal Screening; Peroxisomal Disorders; Peroxisomes | 2012 |
Brown adipose tissue mitochondria oxidizing fatty acids generate high levels of reactive oxygen species irrespective of the uncoupling protein-1 activity state.
Topics: Adipose Tissue, Brown; Animals; Carnitine; Fatty Acids; Hydrogen Peroxide; Ion Channels; Membrane Potential, Mitochondrial; Mitochondria; Mitochondrial Proteins; Nigericin; Onium Compounds; Oxidation-Reduction; Rats; Reactive Oxygen Species; Rotenone; Uncoupling Protein 1 | 2012 |
Deletion of CaMKK2 from the liver lowers blood glucose and improves whole-body glucose tolerance in the mouse.
Topics: Adenylate Kinase; Animals; Antigens, Neoplasm; Blood Glucose; Calcium-Calmodulin-Dependent Protein Kinase Kinase; Carnitine; Catecholamines; Cells, Cultured; Diet, High-Fat; Eating; Fatty Liver; Gene Knockout Techniques; Gluconeogenesis; Glucose; Glucose Intolerance; Hepatocytes; Homeostasis; Intra-Abdominal Fat; Lipid Metabolism; Liver; Mice; Mice, Knockout; Phospholipases A1; Primary Cell Culture; Signal Transduction | 2012 |
Postmortem tandem mass spectrometry profiling for detection of infection in unexpected infant death.
Topics: Autopsy; Bile; Biomarkers; Carnitine; Cause of Death; Communicable Diseases; Forensic Toxicology; Humans; Infant; Infant Mortality; Infant, Newborn; Linear Models; London; Postmortem Changes; Predictive Value of Tests; Reference Standards; Retrospective Studies; Risk Factors; Sudden Infant Death; Tandem Mass Spectrometry | 2012 |
Metabolic decompensation in methylmalonic aciduria: which biochemical parameters are discriminative?
Topics: Acid-Base Equilibrium; Acidosis; Adolescent; Adult; Amino Acid Metabolism, Inborn Errors; Ammonia; Bicarbonates; Carnitine; Child; Child, Preschool; Female; Follow-Up Studies; Humans; Infant; Infant, Newborn; Male; Young Adult | 2012 |
Analysis of acylcarnitine levels by tandem mass spectrometry in epileptic children receiving valproate and oxcarbazepine.
Topics: Adolescent; Anticonvulsants; Carbamazepine; Carnitine; Child; Child, Preschool; Chromatography, High Pressure Liquid; Epilepsy; Female; Humans; Male; Oxcarbazepine; Prospective Studies; Seizures; Tandem Mass Spectrometry; Valproic Acid | 2011 |
Quantification of acylglycines in human urine by HPLC electrospray ionization-tandem mass spectrometry and the establishment of pediatric reference interval in local Chinese.
Topics: 1-Butanol; Acylation; Adolescent; Asian People; Calibration; Carnitine; Child; Child, Preschool; Chromatography, High Pressure Liquid; Deuterium; Female; Glycine; Humans; Infant; Infant, Newborn; Male; Metabolism, Inborn Errors; Reference Values; Sensitivity and Specificity; Solid Phase Extraction; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry | 2012 |
Metabolomic profiling of fatty acid and amino acid metabolism in youth with obesity and type 2 diabetes: evidence for enhanced mitochondrial oxidation.
Topics: Absorptiometry, Photon; Adolescent; Amino Acids; Carnitine; Diabetes Mellitus, Type 2; Fasting; Fatty Acids; Female; Humans; Male; Obesity | 2012 |
Metabolic profiles predict adverse events after coronary artery bypass grafting.
Topics: Aged; Biomarkers; Carnitine; Coronary Artery Bypass; Coronary Artery Disease; Energy Metabolism; Female; Humans; Kaplan-Meier Estimate; Ketones; Male; Mass Spectrometry; Metabolomics; Middle Aged; Multivariate Analysis; Myocardial Infarction; North Carolina; Odds Ratio; Principal Component Analysis; Proportional Hazards Models; Reoperation; Risk Assessment; Risk Factors; Time Factors; Treatment Outcome | 2012 |
Serum metabolomics reveals the deregulation of fatty acids metabolism in hepatocellular carcinoma and chronic liver diseases.
Topics: Carcinoma, Hepatocellular; Carnitine; Chromatography, Liquid; Chronic Disease; Fatty Acids; Humans; Liver Diseases; Liver Neoplasms; Mass Spectrometry; Metabolomics | 2012 |
Identification by site-directed mutagenesis of a hydrophobic binding site of the mitochondrial carnitine/acylcarnitine carrier involved in the interaction with acyl groups.
Topics: Acylation; Animals; Binding Sites; Carnitine; Carnitine Acyltransferases; Computational Biology; Enzyme Inhibitors; Hydrophobic and Hydrophilic Interactions; Kinetics; Mitochondria; Models, Molecular; Mutagenesis, Site-Directed; Mutant Proteins; Palmitoylcarnitine; Protein Binding; Rats; Time Factors | 2012 |
Long-term correction of very long-chain acyl-coA dehydrogenase deficiency in mice using AAV9 gene therapy.
Topics: Acyl-CoA Dehydrogenase, Long-Chain; Animals; Carnitine; Congenital Bone Marrow Failure Syndromes; Dependovirus; Gene Expression; Genetic Therapy; Genetic Vectors; Lipid Metabolism; Lipid Metabolism, Inborn Errors; Liver; Mice; Mice, Knockout; Mitochondrial Diseases; Muscle, Skeletal; Muscular Diseases; Phenotype; Tissue Distribution; Transduction, Genetic | 2012 |
Intrahepatic diacylglycerol content is associated with hepatic insulin resistance in obese subjects.
Topics: Adult; Carnitine; Ceramides; Diglycerides; Female; Glucose; Humans; Insulin Resistance; Liver; Male; Obesity, Morbid | 2012 |
Serum metabolomic profiles from patients with acute kidney injury: a pilot study.
Topics: Acute Kidney Injury; Adult; Amino Acids; Biomarkers; Carnitine; Case-Control Studies; Chromatography, High Pressure Liquid; Discriminant Analysis; Female; Humans; Male; Mass Spectrometry; Metabolic Networks and Pathways; Metabolome; Metabolomics; Pilot Projects | 2012 |
Serum metabolite concentrations and decreased GFR in the general population.
Topics: Carnitine; Creatinine; Cross-Sectional Studies; Cystatin C; Female; Glomerular Filtration Rate; Humans; Kidney Function Tests; Male; Metabolomics; Middle Aged; Reference Values; Renal Insufficiency, Chronic | 2012 |
Tissue-specific splicing of an Ndufs6 gene-trap insertion generates a mitochondrial complex I deficiency-specific cardiomyopathy.
Topics: Adenosine Triphosphate; Animals; Animals, Newborn; Blotting, Western; Cardiomyopathies; Carnitine; Cell Line; Electron Transport Complex I; Female; Gene Expression Profiling; Heart; Humans; In Vitro Techniques; Kaplan-Meier Estimate; Male; Mice; Mice, 129 Strain; Mice, Inbred C57BL; Mice, Knockout; Microscopy, Electron; Mitochondria; Mitochondrial Diseases; Mutagenesis, Insertional; Myocardium; NADH Dehydrogenase; Reverse Transcriptase Polymerase Chain Reaction; RNA Splicing | 2012 |
Analysis of acylcarnitine profiles in umbilical cord blood and during the early neonatal period by electrospray ionization tandem mass spectrometry.
Topics: Brazil; Breast Feeding; Carnitine; Dried Blood Spot Testing; Fatty Acids; Female; Fetal Blood; Humans; Infant, Newborn; Male; Neonatal Screening; Spectrometry, Mass, Electrospray Ionization; Statistics, Nonparametric; Tandem Mass Spectrometry | 2012 |
Changing metabolic signatures of amino acids and lipids during the prediabetic period in a pig model with impaired incretin function and reduced β-cell mass.
Topics: Aging; Amino Acids; Animals; Animals, Genetically Modified; Biomarkers; Carnitine; Diglycerides; Disease Progression; Glucose Tolerance Test; Incretins; Insulin; Insulin Secretion; Insulin-Secreting Cells; Lipids; Lysophosphatidylcholines; Phospholipid Ethers; Prediabetic State; Receptors, Gastrointestinal Hormone; Sphingomyelins; Swine; Transcriptome | 2012 |
MCAD deficiency in Denmark.
Topics: Acyl-CoA Dehydrogenase; Alleles; Base Sequence; Carnitine; Denmark; Family; Female; Genetic Association Studies; Genotype; Humans; Incidence; Infant; Infant, Newborn; Lipid Metabolism, Inborn Errors; Male; Mutation; Neonatal Screening; Phenotype; Tandem Mass Spectrometry | 2012 |
Muscle-specific deletion of carnitine acetyltransferase compromises glucose tolerance and metabolic flexibility.
Topics: Acetyl Coenzyme A; Acetylcarnitine; Animals; Carbon; Carnitine; Carnitine O-Acetyltransferase; Cells, Cultured; Energy Metabolism; Fatty Acids; Glucose; Glucose Tolerance Test; Humans; Insulin; Insulin Resistance; Mice; Mice, Knockout; Mitochondria; Muscle Fibers, Skeletal | 2012 |
Diagnosis of a patient with a kinetic variant of medium and short-chain 3-hydroxyacyl-CoA dehydrogenase deficiency by newborn screening.
Topics: 3-Hydroxyacyl CoA Dehydrogenases; Carnitine; Child, Preschool; Genetic Variation; Humans; Infant, Newborn; Metabolism, Inborn Errors; Molecular Sequence Data; Mutation; Neonatal Screening | 2012 |
Mutations at the flavin binding site of ETF:QO yield a MADD-like severe phenotype in Drosophila.
Topics: Alleles; Amino Acid Sequence; Animals; Binding Sites; Carnitine; Drosophila; Electron-Transferring Flavoproteins; Flavin-Adenine Dinucleotide; Flavins; Genotype; Models, Molecular; Molecular Sequence Data; Multiple Acyl Coenzyme A Dehydrogenase Deficiency; Mutation; Phenotype | 2012 |
Muscle or liver-specific Sirt3 deficiency induces hyperacetylation of mitochondrial proteins without affecting global metabolic homeostasis.
Topics: Acetylation; Adenosine Triphosphate; Animals; Blotting, Western; Carnitine; Energy Metabolism; Female; Gene Expression; Glutathione; Homeostasis; Liver; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Mitochondria; Mitochondrial Proteins; Muscle, Skeletal; Oxidation-Reduction; Reactive Oxygen Species; Reverse Transcriptase Polymerase Chain Reaction; Sirtuin 3; Superoxide Dismutase | 2012 |
Metabolic autopsy with postmortem cultured fibroblasts in sudden unexpected death in infancy: diagnosis of mitochondrial respiratory chain disorders.
Topics: Autopsy; Carnitine; Cells, Cultured; Electron Transport; Enzyme Assays; Female; Fibroblasts; Humans; Infant; Infant, Newborn; Liver; Male; Mitochondrial Diseases; Myocardium; Postmortem Changes; Sudden Infant Death | 2012 |
Increases in bioavailability of poorly absorbed drug by acylcarnitine.
Topics: Administration, Oral; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Availability; Carnitine; Claudin-4; Colon; Fluorescent Dyes; Injections, Intravenous; Intestinal Absorption; Isoquinolines; Jejunum; L-Lactate Dehydrogenase; Laurates; Male; Palmitoylcarnitine; Rats; Rats, Wistar | 2012 |
[Hepatotoxicity of perfluorooctanoic acid in human hepatocytes using metabonomics].
Topics: Caprylates; Carnitine; Cell Line; Chromatography, High Pressure Liquid; Fluorocarbons; Hepatocytes; Humans; Mass Spectrometry; Metabolomics | 2012 |
Characterization of the molecular spectrum of Medium-Chain Acyl-CoA Dehydrogenase Deficiency in a Greek newborns cohort: identification of a novel variant.
Topics: Acyl-CoA Dehydrogenase; Alleles; Base Sequence; Carnitine; Genetic Association Studies; Greece; Humans; Infant, Newborn; Mitochondrial Diseases; Molecular Sequence Data; Neonatal Screening; Polymorphism, Restriction Fragment Length; Prevalence; Sequence Analysis, DNA | 2012 |
Thyroid hormone stimulates hepatic lipid catabolism via activation of autophagy.
Topics: Animals; Autophagy; Autophagy-Related Protein 5; Carnitine; Cell Line, Tumor; Fatty Acids; Gene Expression Profiling; Gene Knockdown Techniques; Hepatocytes; Histone Deacetylases; Humans; Ketone Bodies; Lipid Metabolism; Liver; Male; Metabolic Networks and Pathways; Metabolome; Mice; Mice, Inbred C57BL; Microtubule-Associated Proteins; Nuclear Receptor Co-Repressor 1; Oligonucleotide Array Sequence Analysis; Oxidation-Reduction; Phagosomes; Protein Binding; Receptors, Thyroid Hormone; RNA Interference; Triiodothyronine | 2012 |
A compendium of inborn errors of metabolism mapped onto the human metabolic network.
Topics: Acetyl Coenzyme A; Amino Acids; Brain; Carbohydrate Metabolism; Carnitine; Dried Blood Spot Testing; Fatty Acids; Genome, Human; Humans; Infant, Newborn; Lipid Metabolism; Metabolic Networks and Pathways; Metabolism, Inborn Errors; Metabolomics; Oxidation-Reduction; Tandem Mass Spectrometry | 2012 |
Metabolomic profiling reveals mitochondrial-derived lipid biomarkers that drive obesity-associated inflammation.
Topics: Adipose Tissue; Amino Acids; Analysis of Variance; Animals; Biomarkers; Blotting, Western; Carnitine; Chromatography, Liquid; Cluster Analysis; Computational Biology; Diet; Fatty Acids; Gene Expression Regulation; Inflammation; Laurates; Macrophages; Metabolic Syndrome; Metabolomics; Mitochondria; Obesity; Principal Component Analysis; Rats; Tandem Mass Spectrometry | 2012 |
Decreased expression of adipose CD36 and FATP1 are associated with increased plasma non-esterified fatty acids during prolonged fasting in northern elephant seal pups (Mirounga angustirostris).
Topics: Adipose Tissue; Animals; Animals, Newborn; Blotting, Western; Body Weight; Carnitine; Carnitine O-Palmitoyltransferase; CD36 Antigens; Fasting; Fatty Acid Transport Proteins; Fatty Acids, Nonesterified; Glucose; Glycerol; Intercellular Signaling Peptides and Proteins; Lipase; Lipid Metabolism; Phosphoenolpyruvate Carboxykinase (ATP); Seals, Earless; Time Factors; Triglycerides | 2012 |
Cardiac-specific deletion of acetyl CoA carboxylase 2 prevents metabolic remodeling during pressure-overload hypertrophy.
Topics: Acetyl-CoA Carboxylase; Animals; Aorta; Blotting, Western; Cardiomegaly; Carnitine; Constriction, Pathologic; Fatty Acids; Female; Fibrosis; Heart; In Vitro Techniques; Male; Malonyl Coenzyme A; Mice; Mice, 129 Strain; Mice, Inbred C57BL; Mice, Knockout; Mitochondria, Heart; Myocardium; Oxidation-Reduction; Pressure; Ventricular Remodeling | 2012 |
Analysis of serum metabolic profiles in women with endometrial cancer and controls in a population-based case-control study.
Topics: Adult; Aged; Aging; Algorithms; Amino Acids; Body Mass Index; Body Weight; Carnitine; Case-Control Studies; Data Interpretation, Statistical; Endometrial Neoplasms; Fatty Acids; Female; Humans; Male; Middle Aged; Poland; Population; Quality Control | 2012 |
Rapid and weight-independent improvement of glucose tolerance induced by a peptide designed to elicit apoptosis in adipose tissue endothelium.
Topics: Adipose Tissue, White; Animals; Apoptosis; Blood Glucose; Carnitine; Diet, High-Fat; Energy Intake; Glucose Tolerance Test; Homeostasis; Intercellular Signaling Peptides and Proteins; Lipid Metabolism; Male; Metabolic Networks and Pathways; Mice; Mice, Inbred C57BL; Mitochondria; Peptides; Triglycerides | 2012 |
Direct and quantitative analysis of underivatized acylcarnitines in serum and whole blood using paper spray mass spectrometry.
Topics: Carnitine; Dried Blood Spot Testing; Humans; Infant, Newborn; Limit of Detection; Lipid Metabolism, Inborn Errors; Mass Spectrometry; Reproducibility of Results; Time Factors | 2012 |
A rapid UPLC-MS/MS method for simultaneous separation of 48 acylcarnitines in dried blood spots and plasma useful as a second-tier test for expanded newborn screening.
Topics: Calibration; Carnitine; Chromatography, Liquid; Dried Blood Spot Testing; Flow Injection Analysis; Humans; Infant, Newborn; Isomerism; Limit of Detection; Metabolism, Inborn Errors; Neonatal Screening; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry | 2012 |
Functional redundancy of mitochondrial enoyl-CoA isomerases in the oxidation of unsaturated fatty acids.
Topics: Animals; Blood Glucose; Carbon-Carbon Double Bond Isomerases; Carnitine; Cells, Cultured; Chromatography, High Pressure Liquid; Dodecenoyl-CoA Isomerase; Fatty Acids, Unsaturated; Immunoblotting; Mass Spectrometry; Mice; Mice, Knockout; Mitochondria; Oxidation-Reduction; Real-Time Polymerase Chain Reaction | 2012 |
Measurement of acylcarnitine substrate to product ratios specific to biotin-dependent carboxylases offers a combination of indicators of biotin status in humans.
Topics: Acetyl-CoA Carboxylase; Biomarkers; Biotin; Carbon-Carbon Ligases; Carbon-Nitrogen Ligases; Carnitine; Chromatography, Liquid; Deficiency Diseases; Glutarates; Humans; Methylmalonyl-CoA Decarboxylase; Reproducibility of Results; Substrate Specificity; Tandem Mass Spectrometry | 2012 |
Bezafibrate can be a new treatment option for mitochondrial fatty acid oxidation disorders: evaluation by in vitro probe acylcarnitine assay.
Topics: Bezafibrate; Carboxylic Acids; Carnitine; Cells, Cultured; Fatty Acids; Fibroblasts; Humans; Mitochondrial Diseases; Oxidation-Reduction | 2012 |
A quantitative method for acylcarnitines and amino acids using high resolution chromatography and tandem mass spectrometry in newborn screening dried blood spot analysis.
Topics: Amino Acids; Carnitine; Chromatography, High Pressure Liquid; Dried Blood Spot Testing; Humans; Infant, Newborn; Linear Models; Neonatal Screening; Reproducibility of Results; Sensitivity and Specificity; Tandem Mass Spectrometry | 2012 |
Long-chain acylcarnitines regulate the hERG channel.
Topics: Carnitine; Dose-Response Relationship, Drug; Electrophysiological Phenomena; Ether-A-Go-Go Potassium Channels; Extracellular Space; HEK293 Cells; Humans; Intracellular Space | 2012 |
Mass spectrometry images acylcarnitines, phosphatidylcholines, and sphingomyelin in MDA-MB-231 breast tumor models.
Topics: Animals; Breast Neoplasms; Carnitine; Cell Line, Tumor; Cell Transformation, Neoplastic; Humans; Mass Spectrometry; Mice; Molecular Imaging; Phosphatidylcholines; Sphingomyelins | 2013 |
Abnormal newborn screens and acylcarnitines in HIV-exposed and ARV-exposed infants.
Topics: Anti-Retroviral Agents; Carnitine; Case-Control Studies; HIV Infections; Humans; Infant, Newborn; Infant, Newborn, Diseases; Neonatal Screening; New York | 2013 |
Expanded newborn screening of inborn errors of metabolism by capillary electrophoresis-electrospray ionization-mass spectrometry (CE-ESI-MS).
Topics: Amino Acids; Carnitine; Dried Blood Spot Testing; Electrophoresis, Capillary; Humans; Infant, Newborn; Maleimides; Metabolism, Inborn Errors; Neonatal Screening; Spectrometry, Mass, Electrospray Ionization; Sulfhydryl Compounds | 2013 |
Feasibility of electroextraction as versatile sample preconcentration for fast and sensitive analysis of urine metabolites, demonstrated on acylcarnitines.
Topics: Carnitine; Chemical Fractionation; Chromatography, Liquid; Electrophoresis, Capillary; Equipment Design; Feasibility Studies; Humans; Limit of Detection; Linear Models; Mass Spectrometry; Metabolomics; Reproducibility of Results; Urinalysis | 2012 |
Extraction and analysis of carnitine and acylcarnitines by electrospray ionization tandem mass spectrometry directly from dried blood and plasma spots using a novel autosampler.
Topics: Automation; Carnitine; Dried Blood Spot Testing; Humans; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry | 2012 |
PGC-1α improves glucose homeostasis in skeletal muscle in an activity-dependent manner.
Topics: Animals; Carnitine; Cells, Cultured; Citric Acid Cycle; Fatty Acid Synthases; Glucose; Homeostasis; Lipogenesis; Male; Mice; Muscle, Skeletal; Oxidative Phosphorylation; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; Physical Conditioning, Animal; Sphingosine; Trans-Activators; Transcription Factors | 2013 |
Acylcarnitine profile in thyroid disease.
Topics: Adult; Aged; Carnitine; Female; Humans; Hyperthyroidism; Hypothyroidism; Male; Middle Aged; Reference Values; Thyroxine | 2013 |
L-carnitine and long-chain acylcarnitines are positively correlated with ambulatory blood pressure in humans: the SABPA study.
Topics: Adult; Black People; Blood Pressure; Blood Pressure Monitoring, Ambulatory; Carnitine; Cross-Sectional Studies; Humans; Hypertension; Male; Middle Aged; White People | 2013 |
Intracellular in vitro probe acylcarnitine assay for identifying deficiencies of carnitine transporter and carnitine palmitoyltransferase-1.
Topics: Biological Transport; Cardiomyopathies; Carnitine; Carnitine Acyltransferases; Carnitine O-Palmitoyltransferase; Cells, Cultured; Fatty Acids; Fibroblasts; Humans; Hyperammonemia; Hypoglycemia; Lipid Metabolism, Inborn Errors; Mitochondria; Muscular Diseases; Oxidation-Reduction; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry | 2013 |
The heritability of metabolic profiles in newborn twins.
Topics: Birth Weight; Carnitine; Female; Gestational Age; Humans; Infant, Newborn; Inheritance Patterns; Linear Models; Male; Metabolome; Neonatal Screening; Thyrotropin; Trypsinogen; Twins, Dizygotic; Twins, Monozygotic | 2013 |
Consumption of a high β-glucan barley flour improves glucose control and fatty liver and increases muscle acylcarnitines in the Zucker diabetic fatty rat.
Topics: Adiponectin; Animals; beta-Glucans; Blood Glucose; Body Weight; Carnitine; Cholesterol; Diabetes Mellitus, Type 2; Dietary Fiber; Disease Models, Animal; Fatty Acids, Nonesterified; Fatty Liver; Flour; Glucose Tolerance Test; Hordeum; Insulin; Insulin Resistance; Intestine, Small; Ketones; Liver; Obesity; Organ Size; Postprandial Period; Rats; Rats, Zucker; Thiobarbituric Acid Reactive Substances; Triglycerides | 2013 |
Similarities in serum acylcarnitine patterns in type 1 and type 2 diabetes mellitus and in metabolic syndrome.
Topics: Adult; Aged; Body Mass Index; Carnitine; Case-Control Studies; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Fasting; Female; Humans; Male; Metabolic Syndrome; Middle Aged; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry; Young Adult | 2013 |
Performance of serum and dried blood spot acylcarnitine profiles for detection of fatty acid β-oxidation disorders in adult patients with rhabdomyolysis.
Topics: Adolescent; Adult; Biopsy; Carnitine; Carnitine O-Palmitoyltransferase; Dried Blood Spot Testing; Fatty Acids; Female; Humans; Lipid Metabolism, Inborn Errors; Male; Middle Aged; Mitochondrial Diseases; Oxidation-Reduction; Retrospective Studies; Rhabdomyolysis; Young Adult | 2014 |
New autosampler allows quicker, easier dried blood spot analysis.
Topics: Automation; Carnitine; Dried Blood Spot Testing; Humans; Reproducibility of Results; Spectrometry, Mass, Electrospray Ionization | 2012 |
Long-term dietary effects on substrate selection and muscle fiber type in very-long-chain acyl-CoA dehydrogenase deficient (VLCAD(-/-)) mice.
Topics: Acyl-CoA Dehydrogenase, Long-Chain; Animals; Carnitine; Diet, Fat-Restricted; Dietary Fats; Energy Metabolism; Lipids; Lipogenesis; Liver; Mice; Mice, Transgenic; Muscle Fibers, Skeletal; Substrate Specificity; Triglycerides | 2013 |
Sodium oxybate intolerance associated with familial serum acylcarnitine elevation.
Topics: Acyl-CoA Dehydrogenase; Carnitine; Child; Female; Humans; Hypnotics and Sedatives; Male; Middle Aged; Narcolepsy; Polymorphism, Single Nucleotide; Sleep Initiation and Maintenance Disorders; Sodium Oxybate | 2013 |
Carnitine palmitoyltransferase 2 and carnitine/acylcarnitine translocase are involved in the mitochondrial synthesis and export of acylcarnitines.
Topics: Acyl-CoA Dehydrogenase; Carnitine; Carnitine Acyltransferases; Carnitine O-Palmitoyltransferase; Gene Knockdown Techniques; Humans; Membrane Transport Proteins; Mitochondria; Mitochondrial Diseases; Organic Cation Transport Proteins; Solute Carrier Family 22 Member 5 | 2013 |
Nutritional and metabolic findings in patients with Prader-Willi syndrome diagnosed in early infancy.
Topics: Arginine; Carboxylic Acids; Carnitine; Chromosomes, Human, Pair 15; Diet Therapy; Early Diagnosis; Failure to Thrive; Female; Gene Deletion; Humans; In Situ Hybridization, Fluorescence; Infant; Infant Nutrition Disorders; Infant, Newborn; Male; Prader-Willi Syndrome; Time-to-Treatment | 2012 |
Rapid quantitative analysis of carnitine and acylcarnitines by ultra-high performance-hydrophilic interaction liquid chromatography-tandem mass spectrometry.
Topics: Animals; Carnitine; Chromatography, High Pressure Liquid; Humans; Infant, Newborn; Liver; Muscle, Skeletal; Myocardium; Rats; Tandem Mass Spectrometry | 2013 |
Unique acyl-carnitine profiles are potential biomarkers for acquired mitochondrial disease in autism spectrum disorder.
Topics: Biomarkers; Carnitine; Child; Child Development Disorders, Pervasive; Cohort Studies; DNA, Mitochondrial; Electron Transport; Fatty Acids; Female; Humans; Male; Mitochondrial Diseases; Muscle, Skeletal; Propionates | 2013 |
Metabolomic distinction of microvascular effects of lipoprotein apheresis--a pilot study.
Topics: Adult; Aged; Biomarkers; Blood Component Removal; Carnitine; Chi-Square Distribution; Decision Trees; Female; Humans; Hyperlipidemias; Lipoproteins; Lysophosphatidylcholines; Male; Metabolomics; Methionine; Microvessels; Middle Aged; Ornithine; Photic Stimulation; Pilot Projects; Retinal Vessels; Risk Assessment; Risk Factors; ROC Curve; Serine; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry; Treatment Outcome | 2013 |
Metabolomic analyses of faeces reveals malabsorption in cirrhotic patients.
Topics: Adult; Amino Acids, Aromatic; Bile Acids and Salts; Bile Pigments; Carnitine; Case-Control Studies; Chromatography, Liquid; Fatty Acids; Feces; Female; Humans; Lipid Metabolism; Liver Cirrhosis; Lysophosphatidylcholines; Malabsorption Syndromes; Male; Mass Spectrometry; Metabolome; Middle Aged | 2013 |
Amino acid and acylcarnitine profiles in premature neonates: a pilot study.
Topics: Amino Acids; Carnitine; Dried Blood Spot Testing; Female; Gestational Age; Humans; Infant, Newborn; Infant, Premature, Diseases; Longitudinal Studies; Male; Metabolism, Inborn Errors; Neonatal Screening; Reference Values; Spectrometry, Mass, Electrospray Ionization | 2013 |
Aberrant Schwann cell lipid metabolism linked to mitochondrial deficits leads to axon degeneration and neuropathy.
Topics: Aniline Compounds; Animals; Axons; Blotting, Western; Carnitine; Cells, Cultured; Fatty Acids; Fluorescent Dyes; Ganglia, Spinal; Lipid Metabolism; Mice; Mice, Knockout; Mice, Transgenic; Microarray Analysis; Mitochondrial Encephalomyopathies; Nerve Degeneration; Peripheral Nervous System Diseases; Protein Serine-Threonine Kinases; Schwann Cells; Xanthenes | 2013 |
UPLC-MS/MS analysis of C5-acylcarnitines in dried blood spots.
Topics: Amino Acid Metabolism, Inborn Errors; Carnitine; Chromatography, High Pressure Liquid; Diagnosis, Differential; Dried Blood Spot Testing; Humans; Infant, Newborn; Isovaleryl-CoA Dehydrogenase; Limit of Detection; Neonatal Screening; Reproducibility of Results; Tandem Mass Spectrometry | 2013 |
Thymidine kinase 2 deficiency-induced mtDNA depletion in mouse liver leads to defect β-oxidation.
Topics: Adenosine Triphosphate; Animals; Carboxypeptidases; Carnitine; Cholesterol; DNA, Mitochondrial; Fatty Acids, Nonesterified; Gene Expression Regulation; Lipid Metabolism; Liver; Mice; Mice, Knockout; Mitochondria, Liver; Oxidation-Reduction; Thymidine Kinase; Transcriptome | 2013 |
Characterization of Pseudomonas aeruginosa growth on O-acylcarnitines and identification of a short-chain acylcarnitine hydrolase.
Topics: Blotting, Western; Carboxylic Ester Hydrolases; Carnitine; Computational Biology; DNA Primers; Electrophoresis, Polyacrylamide Gel; Enzyme Induction; Genetic Vectors; Hydrolysis; Polymerase Chain Reaction; Pseudomonas aeruginosa; Type C Phospholipases | 2013 |
Leucine and protein metabolism in obese Zucker rats.
Topics: 3-Methyl-2-Oxobutanoate Dehydrogenase (Lipoamide); Adipose Tissue; Amino Acids, Branched-Chain; Animals; Biomarkers; Body Weight; Carbon Radioisotopes; Carnitine; Chromatography, Liquid; Creatinine; Leucine; Liver; Male; Metabolomics; Muscle, Skeletal; Obesity; Organ Size; Proteins; Rats; Rats, Zucker; Tandem Mass Spectrometry | 2013 |
Metabolomic profiling reveals a role for caspase-2 in lipoapoptosis.
Topics: Aminooxyacetic Acid; Animals; Apoptosis; Carnitine; Caspase 2; Cell Death; Chromatography, Gel; Enzyme Activation; Fatty Acids; Gene Expression Regulation, Enzymologic; HEK293 Cells; Hepatocytes; Humans; Metabolomics; Palmitates; RNA, Small Interfering; Xenopus laevis | 2013 |
Carnitine supplementation attenuates myocardial lipid accumulation in long-chain acyl-CoA dehydrogenase knockout mice.
Topics: Acyl-CoA Dehydrogenase, Long-Chain; Animals; Carnitine; Dietary Supplements; Disease Models, Animal; Drug Evaluation, Preclinical; Heart; Lipid Metabolism; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Myocardium; Triglycerides | 2013 |
Recurrent myoglobinuria and deranged acylcarnitines due to a mutation in the mtDNA MT-CO2 gene.
Topics: Adult; Carnitine; DNA, Mitochondrial; Electron Transport Complex IV; Humans; Male; Mutation; Myoglobinuria; Recurrence | 2013 |
Production and release of acylcarnitines by primary myotubes reflect the differences in fasting fat oxidation of the donors.
Topics: Acyl-CoA Dehydrogenase; Adult; Carnitine; Fasting; Female; Humans; Lipid Metabolism; Male; Muscle Fibers, Skeletal; Oxidation-Reduction | 2013 |
Differential effects of central ghrelin on fatty acid metabolism in hypothalamic ventral medial and arcuate nuclei.
Topics: Acyl Coenzyme A; AMP-Activated Protein Kinases; Animals; Arcuate Nucleus of Hypothalamus; Blotting, Western; Carboxy-Lyases; Carnitine; Carnitine O-Palmitoyltransferase; Fatty Acids; Ghrelin; Injections, Intraventricular; Lipid Metabolism; Male; Malonyl Coenzyme A; Rats; Rats, Sprague-Dawley; Real-Time Polymerase Chain Reaction; RNA, Messenger; Ventromedial Hypothalamic Nucleus | 2013 |
Matrix-assisted laser desorption/ionization for simultaneous quantitation of (acyl-)carnitines and organic acids in dried blood spots.
Topics: Carnitine; Dried Blood Spot Testing; Female; Humans; Infant, Newborn; Male; Mass Spectrometry; Metabolism, Inborn Errors; Neonatal Screening; Organic Chemicals; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization | 2013 |
Important role of ventromedial hypothalamic carnitine palmitoyltransferase-1a in the control of food intake.
Topics: Acyl Coenzyme A; Animals; Appetite Depressants; Arcuate Nucleus of Hypothalamus; Blotting, Western; Body Weight; Carnitine; Carnitine O-Palmitoyltransferase; Dependovirus; Eating; Enzyme Activation; Epoxy Compounds; Fasting; Genetic Vectors; Hypoglycemic Agents; Injections, Intraventricular; Male; Malonyl Coenzyme A; Rats; Rats, Sprague-Dawley; Ventromedial Hypothalamic Nucleus | 2013 |
Plasma carnitine concentrations after chronic alcohol intoxication.
Topics: Adult; Alcoholic Intoxication; Alcoholism; Carnitine; Female; Humans; Male; Middle Aged; Plasma; Reference Values; Vitamin B Deficiency; Young Adult | 2013 |
Measurement of free carnitine and acylcarnitines in plasma by HILIC-ESI-MS/MS without derivatization.
Topics: Carnitine; Chromatography, Liquid; Humans; Hydrophobic and Hydrophilic Interactions; Isomerism; Sensitivity and Specificity; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry | 2013 |
Fish oil and the pan-PPAR agonist tetradecylthioacetic acid affect the amino acid and carnitine metabolism in rats.
Topics: Amino Acids; Ammonium Compounds; Animals; Body Weight; Carnitine; Diet; Feeding Behavior; Fish Oils; Gene Expression Regulation; Liver; Male; Peroxisome Proliferator-Activated Receptors; Rats; Rats, Wistar; Sulfides; Urea | 2013 |
Impaired mitochondrial β-oxidation in patients with chronic hepatitis C: relation with viral load and insulin resistance.
Topics: Adult; Aged; Carnitine; Fasting; Fatty Acids; Fatty Liver; Female; Hepatitis C, Chronic; Homeostasis; Humans; Insulin; Insulin Resistance; Ketone Bodies; Male; Middle Aged; Mitochondria; Oxidation-Reduction; Viral Core Proteins; Viral Load; Young Adult | 2013 |
Newborn screening for medium-chain acyl-CoA dehydrogenase deficiency: regional experience and high incidence of carnitine deficiency.
Topics: Acyl-CoA Dehydrogenase; Cardiomyopathies; Carnitine; Dietary Supplements; Female; Genetic Association Studies; Genotype; Homozygote; Humans; Hyperammonemia; Incidence; Infant, Newborn; Lipid Metabolism, Inborn Errors; Male; Muscular Diseases; Neonatal Screening; Phenotype; Prevalence; Spain; Vitamin B Complex | 2013 |
Peroxisomes contribute to the acylcarnitine production when the carnitine shuttle is deficient.
Topics: Carnitine; Carnitine Acyltransferases; Carnitine O-Palmitoyltransferase; Cells, Cultured; Fibroblasts; Fluorescent Antibody Technique; Humans; Lauric Acids; Lipid Metabolism, Inborn Errors; Oxidation-Reduction; Peroxisomes; Skin | 2013 |
Five novel mutations in ARG1 gene in Chinese patients of argininemia.
Topics: Amino Acids; Arginase; Asian People; Carnitine; Child; Child, Preschool; DNA Mutational Analysis; Female; Gas Chromatography-Mass Spectrometry; Humans; Hyperargininemia; Male; Mutation | 2013 |
Acylcarnitine esters profiling of serum and follicular fluid in patients undergoing in vitro fertilization.
Topics: Adult; Carnitine; Case-Control Studies; Embryo Transfer; Esters; Female; Fertilization in Vitro; Follicular Fluid; Humans; Male; Oocytes; Pregnancy; Pregnancy Rate; Spectrometry, Mass, Electrospray Ionization; Sperm Injections, Intracytoplasmic; Young Adult | 2013 |
Elaidate, an 18-carbon trans-monoenoic fatty acid, inhibits β-oxidation in human peripheral blood macrophages.
Topics: Carnitine; Cells, Cultured; Fatty Acids; Humans; Macrophages; Oleic Acid; Oleic Acids; Oxidation-Reduction; Plant Oils; Stearates; Tandem Mass Spectrometry | 2014 |
Identification and assay of underivatized urinary acylcarnitines by paper spray tandem mass spectrometry.
Topics: Adult; Calibration; Carnitine; Humans; Limit of Detection; Paper; Reproducibility of Results; Tandem Mass Spectrometry; Young Adult | 2013 |
Variation of serum metabolites related to habitual diet: a targeted metabolomic approach in EPIC-Potsdam.
Topics: Adult; Amino Acids; Carnitine; Chronic Disease; Cross-Sectional Studies; Diabetes Mellitus, Type 2; Diet; Feeding Behavior; Female; Hexoses; Humans; Male; Metabolome; Metabolomics; Middle Aged; Phosphatidylcholines; Risk Factors; Surveys and Questionnaires | 2013 |
Glutathione controls the redox state of the mitochondrial carnitine/acylcarnitine carrier Cys residues by glutathionylation.
Topics: Animals; Biological Transport; Carnitine; Carrier Proteins; Cysteine; Glutaredoxins; Glutathione; Glutathione Disulfide; Mitochondria, Liver; Mutagenesis, Site-Directed; Oxidation-Reduction; Proteolipids; Rats | 2013 |
Biochemical competition makes fatty-acid β-oxidation vulnerable to substrate overload.
Topics: Animals; Carnitine; Fatty Acids; Female; Kinetics; Liver; Metabolic Networks and Pathways; Mitochondria; Models, Biological; NAD; Obesity; Oxidation-Reduction; Palmitoyl Coenzyme A; Palmitoylcarnitine; Rats; Rats, Wistar; Reproducibility of Results | 2013 |
Circulating acylcarnitines as biomarkers of mitochondrial dysfunction after acetaminophen overdose in mice and humans.
Topics: Acetaminophen; Acetylcysteine; Animals; Antidotes; Biomarkers; Carnitine; Chemical and Drug Induced Liver Injury; Drug Overdose; Humans; Male; Metabolomics; Mice; Mice, Inbred C57BL; Mitochondria | 2014 |
Biotinidase knockout mice show cellular energy deficit and altered carbon metabolism gene expression similar to that of nutritional biotin deprivation: clues for the pathogenesis in the human inherited disorder.
Topics: Animals; Biotin; Biotinidase Deficiency; Blood Glucose; Body Weight; Carbon; Carnitine; Diet; Disease Models, Animal; Energy Metabolism; Gene Expression; Humans; Liver; Mice; Mice, Knockout; RNA, Messenger | 2013 |
Daily non-soy legume consumption reverses vascular impairment due to peripheral artery disease.
Topics: Aged; Aged, 80 and over; Ankle Brachial Index; Atherosclerosis; Biomarkers; Carnitine; Carotid Stenosis; Cholesterol; Cholesterol, LDL; Cohort Studies; Diabetes Mellitus, Type 2; Diet; Endothelium, Vascular; Fabaceae; Female; Humans; Hyperlipidemias; Hypertension; Inflammation; Isoflavones; Male; Middle Aged; Muscle, Skeletal; Peripheral Arterial Disease; Time Factors | 2013 |
A fish protein hydrolysate alters fatty acid composition in liver and adipose tissue and increases plasma carnitine levels in a mouse model of chronic inflammation.
Topics: Adipose Tissue; Animals; Carnitine; Caseins; Chronic Disease; Diet, High-Fat; Fatty Acids, Omega-3; Fatty Acids, Omega-6; Female; Fish Proteins; Fishes; Gene Expression; Humans; Inflammation; Liver; Mice; Mice, Transgenic; Ovary; Proteolysis; Tumor Necrosis Factor-alpha | 2013 |
Race and sex differences in small-molecule metabolites and metabolic hormones in overweight and obese adults.
Topics: Aged; Amino Acids, Branched-Chain; Black or African American; Carnitine; Cross-Sectional Studies; Female; Hormones; Humans; Ketones; Male; Metabolome; Middle Aged; Obesity; Overweight; Principal Component Analysis; Sex Characteristics; White People | 2013 |
Identification of biomarkers for apoptosis in cancer cell lines using metabolomics: tools for individualized medicine.
Topics: Alanine; Amino Acids; Apoptosis; Biomarkers; Carnitine; Caspase 3; Caspase 7; Cell Line, Tumor; Etoposide; Flow Injection Analysis; Fluorouracil; Glutamic Acid; HEK293 Cells; Hep G2 Cells; Humans; Metabolomics; Precision Medicine | 2013 |
Separation and identification of underivatized plasma acylcarnitine isomers using liquid chromatography-tandem mass spectrometry for the differential diagnosis of organic acidemias and fatty acid oxidation defects.
Topics: Carnitine; Chromatography, High Pressure Liquid; Diagnosis, Differential; Fatty Acids; Humans; Isomerism; Metabolism, Inborn Errors; Oxidation-Reduction; Reference Standards; Reproducibility of Results; Tandem Mass Spectrometry | 2013 |
Treatable childhood neuronopathy caused by mutations in riboflavin transporter RFVT2.
Topics: Adolescent; Brain; Bulbar Palsy, Progressive; Carnitine; Child; Child, Preschool; Exome; Female; Genotype; Hearing Loss, Sensorineural; Humans; Image Processing, Computer-Assisted; Magnetic Resonance Imaging; Male; Microarray Analysis; Motor Neuron Disease; Mutation; Neurologic Examination; Pedigree; Receptors, G-Protein-Coupled; Riboflavin; RNA; Sequence Analysis, DNA; Sural Nerve; Vitamins; Young Adult | 2014 |
Kinetics of carnitine palmitoyltransferase I (CPT I) in Chinese sucker (Myxocyprinus asiaticus) change with its development.
Topics: Animals; Carnitine; Carnitine O-Palmitoyltransferase; Cypriniformes; Fish Proteins; Kinetics; Liver; Muscle, Skeletal | 2014 |
Effect of Allium macrostemon on a rat model of depression studied by using plasma lipid and acylcarnitine profiles from liquid chromatography/mass spectrometry.
Topics: Allium; Animals; Antidepressive Agents; Carnitine; Chromatography, High Pressure Liquid; Depression; Disease Models, Animal; Lipids; Male; Mass Spectrometry; Medicine, Chinese Traditional; Metabolome; Principal Component Analysis; Rats; Rats, Wistar | 2014 |
A plasma long-chain acylcarnitine predicts cardiovascular mortality in incident dialysis patients.
Topics: Aged; Aged, 80 and over; Biomarkers; Cardiovascular Diseases; Carnitine; Case-Control Studies; Chi-Square Distribution; Chromatography, Liquid; Female; Humans; Kidney Failure, Chronic; Logistic Models; Male; Mass Spectrometry; Metabolomics; Middle Aged; Multivariate Analysis; Odds Ratio; Prospective Studies; Renal Dialysis; Risk Factors; Time Factors; Treatment Outcome; Uremia | 2013 |
Serum metabolic profiles of pregnant women with burdened obstetrical history.
Topics: Abortion, Spontaneous; Amino Acids; Biomarkers; Carnitine; Case-Control Studies; Female; Hexoses; Humans; Phosphatidylcholines; Pregnancy; Sphingomyelins | 2013 |
Effect of carnitine, acetyl-, and propionylcarnitine supplementation on the body carnitine pool, skeletal muscle composition, and physical performance in mice.
Topics: Acetylcarnitine; Administration, Oral; Animals; Biological Availability; Biomarkers; Carnitine; Dietary Supplements; Energy Metabolism; Liver; Male; Mice; Mice, Inbred C57BL; Muscle, Skeletal; Oxidative Stress; Oxygen Consumption; Physical Conditioning, Animal | 2014 |
Changes in mitochondrial carriers exhibit stress-specific signatures in INS-1Eβ-cells exposed to glucose versus fatty acids.
Topics: Animals; Apoptosis; Biological Transport; Carnitine; Cell Line; Cell Survival; DNA; Electron Transport; Energy Metabolism; Fatty Acids; Gene Expression Profiling; Glucose; Insulin; Lipid Metabolism; Mitochondria; Mitochondrial Proteins; Oxidative Phosphorylation; Protein Subunits; Proteome; Rats; Stress, Physiological; Transcription Factors; Transcriptome | 2013 |
Serum levels of acylcarnitines are altered in prediabetic conditions.
Topics: Adult; Aged; Blood Glucose; Body Composition; Carnitine; Diabetes Mellitus, Type 2; Female; Glucose Intolerance; Glucose Tolerance Test; Humans; Male; Middle Aged; Prediabetic State | 2013 |
Obesity and lipid stress inhibit carnitine acetyltransferase activity.
Topics: Acetyl Coenzyme A; Animals; Carnitine; Carnitine O-Acetyltransferase; Carnitine O-Palmitoyltransferase; Cells, Cultured; Diabetes Mellitus; Humans; Lipid Metabolism; Male; Muscle Fibers, Skeletal; Obesity; Pyruvate Dehydrogenase Complex; Rats, Wistar; Rats, Zucker | 2014 |
Identification of the plasma metabolomics as early diagnostic markers between biliary atresia and neonatal hepatitis syndrome.
Topics: Amino Acids; Biliary Atresia; Biomarkers; Carnitine; Chromatography, Liquid; Demography; Discriminant Analysis; Dried Blood Spot Testing; Early Diagnosis; Female; Hepatitis; Humans; Infant, Newborn; Infant, Newborn, Diseases; Least-Squares Analysis; Male; Mass Spectrometry; Metabolomics; Syndrome | 2014 |
Early mitochondrial dysfunction in glycolytic muscle, but not oxidative muscle, of the fructose-fed insulin-resistant rat.
Topics: Aconitate Hydratase; Animals; Carnitine; Diabetes Mellitus, Type 2; Dietary Carbohydrates; Disease Progression; Energy Metabolism; Fatty Acids; Fructose; Glutamic Acid; Glycolysis; Insulin Resistance; Male; Mitochondria, Muscle; Muscle, Skeletal; Oxidative Phosphorylation; Prediabetic State; Pyruvate Dehydrogenase Complex; Pyruvic Acid; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species | 2014 |
Glutaric aciduria type II presenting as myopathy and rhabdomyolysis in a teenager.
Topics: Adolescent; Carnitine; Humans; Male; Multiple Acyl Coenzyme A Dehydrogenase Deficiency; Muscular Diseases; Rhabdomyolysis | 2015 |
Metabolomics signature improves the prediction of cardiovascular events in elderly subjects.
Topics: Aged; Aged, 80 and over; Aging; Biomarkers; Cardiovascular Diseases; Carnitine; Cellular Senescence; Female; Follow-Up Studies; Humans; Male; Metabolic Networks and Pathways; Metabolomics; Myocardial Infarction; Principal Component Analysis; Proportional Hazards Models; Reproducibility of Results; Stroke | 2014 |
Impact of sleep-disordered breathing on myocardial damage and metabolism in patients with chronic heart failure.
Topics: Adult; Aged; Biomarkers; Carnitine; Chronic Disease; Female; Heart Failure; Humans; Male; Middle Aged; Myocardium; Polysomnography; Predictive Value of Tests; Risk Factors; Severity of Illness Index; Sleep Apnea Syndromes; Troponin T; Up-Regulation | 2015 |
The mechanism of Intralipid®-mediated cardioprotection complex IV inhibition by the active metabolite, palmitoylcarnitine, generates reactive oxygen species and activates reperfusion injury salvage kinases.
Topics: Animals; Cardiotonic Agents; Carnitine; Electron Transport Complex IV; Emulsions; Heart; Male; MAP Kinase Signaling System; Mitochondria, Heart; Myocardial Reperfusion Injury; Palmitoylcarnitine; Phospholipids; Proto-Oncogene Proteins c-akt; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Soybean Oil; Ventricular Function, Left | 2014 |
Infants suspected to have very-long chain acyl-CoA dehydrogenase deficiency from newborn screening.
Topics: Acyl-CoA Dehydrogenase, Long-Chain; Carnitine; Congenital Bone Marrow Failure Syndromes; Demography; DNA Mutational Analysis; Fatty Acids; Female; Genotype; Humans; Infant; Infant, Newborn; Lipid Metabolism, Inborn Errors; Male; Mitochondrial Diseases; Muscular Diseases; Neonatal Screening; Phenotype; Reproducibility of Results | 2014 |
Targeted liquid chromatography-mass spectrometry analysis of serum acylcarnitines in acetaminophen toxicity in children.
Topics: Acetaminophen; Acetylcysteine; Adolescent; Age Factors; Alanine Transaminase; Biomarkers; Carnitine; Chemical and Drug Induced Liver Injury; Child; Child, Preschool; Chromatography, High Pressure Liquid; Discriminant Analysis; Female; Humans; Least-Squares Analysis; Male; Mass Spectrometry; Metabolomics; Sex Factors | 2014 |
The molecular and metabolic influence of long term agmatine consumption.
Topics: Agmatine; Animals; Biological Transport, Active; Carnitine; Cyclic AMP; Dietary Fats; Fatty Acids; Gene Expression Regulation; Gluconeogenesis; Humans; Liver; Male; Metabolome; Obesity; Oxidation-Reduction; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; PPAR gamma; Rats; Rats, Sprague-Dawley; Time Factors; Transcription Factors | 2014 |
Short-term stability of amino acids and acylcarnitines in the dried blood spots used to screen newborns for metabolic disorders.
Topics: Amino Acids; Blood Specimen Collection; Carnitine; Dried Blood Spot Testing; Humans; Infant, Newborn; Neonatal Screening; Reproducibility of Results; Sensitivity and Specificity; Specimen Handling; Tandem Mass Spectrometry; Temperature; Time Factors | 2014 |
Linking diet, physical activity, cardiorespiratory fitness and obesity to serum metabolite networks: findings from a population-based study.
Topics: Amino Acids; Biomarkers; Body Mass Index; Carbohydrates; Carnitine; Coffee; Diet; Energy Metabolism; Exercise; Feeding Behavior; Female; Germany; Humans; Life Style; Male; Metabolome; Middle Aged; Obesity; Phospholipids; Physical Fitness; Population Surveillance; Prospective Studies; Risk Factors; Waist Circumference | 2014 |
Fish oil omega-3 fatty acids partially prevent lipid-induced insulin resistance in human skeletal muscle without limiting acylcarnitine accumulation.
Topics: Adult; Carnitine; Fatty Acids, Omega-3; Fish Oils; Glycogen; Humans; Insulin; Insulin Resistance; Lipids; Male; Muscle, Skeletal; Triglycerides | 2014 |
First experience with a fully automated extraction system for simultaneous on-line direct tandem mass spectrometric analysis of amino acids and (acyl-)carnitines in a newborn screening setting.
Topics: Amino Acids; Carnitine; Dried Blood Spot Testing; Equipment Design; Humans; Infant, Newborn; Neonatal Screening; Tandem Mass Spectrometry | 2014 |
Plasma acylcarnitines inadequately reflect tissue acylcarnitine metabolism.
Topics: Adipose Tissue, Brown; Adipose Tissue, White; Algorithms; Animals; Carnitine; Cluster Analysis; Fasting; Fatty Acids; Insulin Resistance; Liver; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Muscle, Skeletal; Myocardium; Predictive Value of Tests; Tandem Mass Spectrometry | 2014 |
Acylcarnitines activate proinflammatory signaling pathways.
Topics: Animals; Carnitine; Cell Line, Transformed; Cell Line, Tumor; Cyclooxygenase 2; Cytokines; Diabetes Mellitus, Type 2; Docosahexaenoic Acids; Enzyme Induction; Gene Silencing; Humans; Macrophage Activation; Macrophages; MAP Kinase Signaling System; Mice; Myeloid Differentiation Factor 88; Myristic Acids; Phosphorylation; Protein Processing, Post-Translational; Receptors, Pattern Recognition; Recombinant Proteins; Toll-Like Receptor 2 | 2014 |
Limited brain metabolism changes differentiate between the progression and clearance of rabies virus.
Topics: 3-Hydroxybutyric Acid; Adaptive Immunity; Animals; Antiviral Agents; Brain; Carnitine; Corticosterone; Disease Progression; Energy Metabolism; Female; Gene Expression; Host-Pathogen Interactions; Hypothalamo-Hypophyseal System; Mice; Pituitary-Adrenal System; Pyridines; Rabies; Rabies virus; Viral Load; Viral Proteins; Viral Vaccines | 2014 |
Urinary metabolomic study of non-small cell lung carcinoma based on ultra high performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry.
Topics: Adult; Aged; Carnitine; Chromatography, High Pressure Liquid; Female; Humans; Lung Neoplasms; Male; Mass Spectrometry; Metabolomics; Middle Aged; Small Cell Lung Carcinoma; Urine | 2014 |
Functional analysis of iPSC-derived myocytes from a patient with carnitine palmitoyltransferase II deficiency.
Topics: Bezafibrate; Carnitine; Carnitine O-Palmitoyltransferase; Cell Differentiation; Cells, Cultured; Fibroblasts; Gene Expression Regulation; Humans; Male; Metabolism, Inborn Errors; Muscle Cells; Palmitoylcarnitine; Pluripotent Stem Cells; Young Adult | 2014 |
Modelling of UPLC behaviour of acylcarnitines by quantitative structure-retention relationships.
Topics: Algorithms; Calibration; Carnitine; Chromatography, High Pressure Liquid; Least-Squares Analysis; Linear Models; Models, Theoretical; Principal Component Analysis; Quantitative Structure-Activity Relationship; Reproducibility of Results | 2014 |
Spectrum analysis of common inherited metabolic diseases in Chinese patients screened and diagnosed by tandem mass spectrometry.
Topics: Acyl-CoA Dehydrogenase; Adolescent; Adult; Amino Acid Metabolism, Inborn Errors; Amino Acids; Carboxylic Acids; Carnitine; Child; Child, Preschool; China; Fatty Acids; Female; Humans; Infant; Infant, Newborn; Lipid Metabolism, Inborn Errors; Male; Metabolic Diseases; Middle Aged; Oxidation-Reduction; Phenylketonurias; Tandem Mass Spectrometry | 2015 |
Human serum acylcarnitine profiles in different glucose tolerance states.
Topics: Biomarkers; Blood Glucose; Carnitine; Chromatography, Liquid; Diabetes Mellitus, Type 2; Fasting; Female; Glucose Intolerance; Glucose Tolerance Test; Humans; Male; Middle Aged; Oxidation-Reduction; Prediabetic State; Spectrometry, Mass, Electrospray Ionization | 2014 |
Metabolic heritability at birth: implications for chronic disease research.
Topics: Acyl-CoA Dehydrogenase; Acyl-CoA Dehydrogenases; Adult; Carnitine; Chronic Disease; Female; Humans; Infant, Newborn; Lipid Metabolism, Inborn Errors; Male; Metabolism, Inborn Errors; Organic Cation Transport Proteins; Symporters; Tandem Mass Spectrometry | 2014 |
Postanalytical tools improve performance of newborn screening by tandem mass spectrometry.
Topics: Amino Acids; California; Carnitine; Computational Biology; False Positive Reactions; Female; Humans; Infant, Newborn; Internet; Male; Minnesota; Neonatal Screening; Predictive Value of Tests; Retrospective Studies; Software; Tandem Mass Spectrometry | 2014 |
Long-chain acylcarnitine content determines the pattern of energy metabolism in cardiac mitochondria.
Topics: Animals; Carnitine; Energy Metabolism; Fasting; Fatty Acids; Glucose; Male; Mice; Mice, Inbred ICR; Mitochondria, Heart; Models, Animal; Palmitoylcarnitine; Rats; Rats, Wistar | 2014 |
Development of an assay to simultaneously measure orotic acid, amino acids, and acylcarnitines in dried blood spots.
Topics: Amino Acids; Carnitine; Dried Blood Spot Testing; Female; Flow Injection Analysis; Humans; Infant; Infant, Newborn; Male; Orotic Acid; Reproducibility of Results; Tandem Mass Spectrometry; Time Factors; Urea Cycle Disorders, Inborn | 2014 |
[C5-carnitine false positive results in newborn screening: what is the cause?].
Topics: Amino Acid Metabolism, Inborn Errors; Biotransformation; Breast Feeding; Carnitine; Coenzyme A Ligases; Cosmetics; False Positive Reactions; Female; Humans; Infant, Newborn; Isovaleryl-CoA Dehydrogenase; Maternal-Fetal Exchange; Neonatal Screening; Ointments; Pentanoic Acids; Pregnancy; Tandem Mass Spectrometry | 2015 |
Continuous-flow microelectroextraction for enrichment of low abundant compounds.
Topics: Carnitine; Chromatography, Reverse-Phase; Electrochemical Techniques; Equipment Design; Humans; Laurates; Limit of Detection; Mass Spectrometry; Solid Phase Extraction | 2014 |
The effect of long-term oral L-carnitine administration on insulin sensitivity, glucose disposal, plasma concentrations of leptin and acylcarnitines, and urinary acylcarnitine excretion in warmblood horses.
Topics: Animals; Carnitine; Glucose Clamp Technique; Horses; Insulin Resistance; Leptin; Male; Plasma; Radioimmunoassay; Vitamin B Complex | 2014 |
Carnitine/acylcarnitine translocase and carnitine palmitoyltransferase 2 form a complex in the inner mitochondrial membrane.
Topics: Animals; Blotting, Western; Carnitine; Carnitine Acyltransferases; Carnitine O-Palmitoyltransferase; Cross-Linking Reagents; Formaldehyde; Immunoprecipitation; Membrane Transport Proteins; Mitochondria, Liver; Mitochondrial Membranes; Models, Molecular; Native Polyacrylamide Gel Electrophoresis; Protein Binding; Protein Conformation; Rats | 2014 |
Gestational age and age at sampling influence metabolic profiles in premature infants.
Topics: Age Factors; Amino Acids; Carnitine; Female; Gestational Age; Humans; Infant, Newborn; Infant, Premature; Male; Metabolome | 2014 |
Hepatic metabolite profiles in mice with a suboptimal selenium status.
Topics: Animals; Carnitine; Chromatography, Liquid; Gas Chromatography-Mass Spectrometry; Glycogen; Lipid Peroxidation; Liver; Male; Membrane Lipids; Mice; Mice, Inbred C57BL; Selenium; Tandem Mass Spectrometry; Triiodothyronine | 2014 |
[Carnitine and acylcarnitine percentiles in very low birth weight premature newborn screening samples].
Topics: Carnitine; Female; Humans; Infant, Newborn; Infant, Premature; Infant, Very Low Birth Weight; Male; Neonatal Screening; Reference Values; Retrospective Studies | 2015 |
Metabolite signatures of exercise training in human skeletal muscle relate to mitochondrial remodelling and cardiometabolic fitness.
Topics: Adolescent; Adult; Aged; Amino Acids, Branched-Chain; Carnitine; Exercise; Female; Humans; Male; Metabolomics; Middle Aged; Mitochondria, Muscle; Muscle, Skeletal; Succinic Acid; Young Adult | 2014 |
Increased and early lipolysis in children with long-chain 3-hydroxyacyl-CoA dehydrogenase (LCHAD) deficiency during fast.
Topics: 3-Hydroxyacyl CoA Dehydrogenases; Age Factors; Biomarkers; Blood Glucose; Calorimetry, Indirect; Cardiomyopathies; Carnitine; Child; Child, Preschool; Energy Metabolism; Fasting; Female; Glycerol; Humans; Hyperglycemia; Isotope Labeling; Lipid Metabolism, Inborn Errors; Lipolysis; Male; Microdialysis; Mitochondrial Myopathies; Mitochondrial Trifunctional Protein; Nervous System Diseases; Postprandial Period; Rhabdomyolysis; Time Factors | 2015 |
Disorders associated with abnormal acylcarnitine profile among high risk Egyptian children.
Topics: Biomarkers; Carnitine; Child, Preschool; Chromatography, High Pressure Liquid; Egypt; Female; Humans; Infant; Infant, Newborn; Male; Metabolism, Inborn Errors; Risk Factors; Spectrometry, Mass, Electrospray Ionization | 2014 |
Evidence that multiple defects in lipid regulation occur before hyperglycemia during the prodrome of type-2 diabetes.
Topics: Adiponectin; Adipose Tissue; Adult; Blood Glucose; Carnitine; Diabetes Mellitus, Type 2; Diabetes, Gestational; Diglycerides; Fasting; Female; Follow-Up Studies; Glucose Tolerance Test; Humans; Hyperglycemia; Insulin; Lipid Metabolism; Metabolome; Phospholipids; Prediabetic State; Pregnancy; Principal Component Analysis | 2014 |
Pioglitazone treatment restores in vivo muscle oxidative capacity in a rat model of diabetes.
Topics: Animals; Biomarkers; Carnitine; Diabetes Mellitus, Type 2; Hypertriglyceridemia; Hypoglycemic Agents; Hypolipidemic Agents; Lipid Metabolism; Male; Mitochondria, Muscle; Mitochondrial Diseases; Mitochondrial Turnover; Muscle, Skeletal; Obesity; Oxidative Phosphorylation; Oxidative Stress; Pioglitazone; PPAR gamma; Rats, Zucker; Thiazolidinediones | 2015 |
Amelioration of acylcarnitine profile using bezafibrate and riboflavin in a case of adult-onset glutaric acidemia type 2 with novel mutations of the electron transfer flavoprotein dehydrogenase (ETFDH) gene.
Topics: Adult; Bezafibrate; Carnitine; Drug Therapy, Combination; Electron-Transferring Flavoproteins; Humans; Hypolipidemic Agents; Iron-Sulfur Proteins; Multiple Acyl Coenzyme A Dehydrogenase Deficiency; Mutation; Oxidoreductases Acting on CH-NH Group Donors; Riboflavin; Treatment Outcome | 2014 |
The first case in Asia of 2-methyl-3-hydroxybutyryl-CoA dehydrogenase deficiency (HSD10 disease) with atypical presentation.
Topics: 3-Hydroxyacyl CoA Dehydrogenases; Acetyl-CoA C-Acetyltransferase; Base Sequence; Carnitine; Child; Diagnosis, Differential; DNA Mutational Analysis; Dyskinesias; Fibroblasts; Glycine; Humans; Hydroxybutyrates; Immunoblotting; Lipid Metabolism, Inborn Errors; Male; Mental Retardation, X-Linked; Mitochondria; Models, Molecular; Point Mutation; Protein Structure, Tertiary | 2014 |
Analysis and interpretation of acylcarnitine profiles in dried blood spot and plasma of preterm and full-term newborns.
Topics: Amino Acids, Branched-Chain; Birth Weight; Bronchopulmonary Dysplasia; Carnitine; Dried Blood Spot Testing; Fatty Acids; Female; Gestational Age; Humans; Infant, Newborn; Infant, Premature; Male; Pulmonary Surfactants; Reference Values; Respiration, Artificial; Respiratory Distress Syndrome, Newborn | 2015 |
Familial very long chain acyl-CoA dehydrogenase deficiency as a cause of neonatal sudden infant death: improved survival by prompt diagnosis.
Topics: Acyl-CoA Dehydrogenase, Long-Chain; Carnitine; Child; Family; Female; Fibroblasts; Humans; Infant; Infant, Newborn; Lipid Metabolism, Inborn Errors; Lymphocytes; Male; Oxidation-Reduction; Palmitates; Perinatal Death; Siblings; Sudden Infant Death; Survival Analysis | 2015 |
Acylcarnitines: potential implications for skeletal muscle insulin resistance.
Topics: Adult; Animals; Antioxidants; Carnitine; Case-Control Studies; Cell Line; Cells, Cultured; Cytokines; Fatty Acids; Female; Humans; Inflammation; Insulin Resistance; Mice; Middle Aged; Muscle Fibers, Skeletal; Muscle, Skeletal; Obesity; Oxidation-Reduction; Oxidative Stress | 2015 |
Genetic activation of pyruvate dehydrogenase alters oxidative substrate selection to induce skeletal muscle insulin resistance.
Topics: Animals; Carnitine; Citric Acid Cycle; Dietary Fats; Enzyme Activation; Fatty Acids; Glucose; Glycogen; Hyperinsulinism; Insulin Resistance; Isoenzymes; Mice; Mice, Inbred C57BL; Mice, Knockout; Models, Biological; Muscle, Skeletal; Nuclear Magnetic Resonance, Biomolecular; Oxidation-Reduction; Oxidative Stress; Phosphorylation; Protein Kinase C; Protein Kinase C-theta; Protein Processing, Post-Translational; Protein Serine-Threonine Kinases; Pyruvate Dehydrogenase Acetyl-Transferring Kinase; Pyruvate Dehydrogenase Complex; Reactive Oxygen Species; RNA, Messenger; Substrate Specificity | 2014 |
Plasma metabolomic profiles of breast cancer patients after short-term limonene intervention.
Topics: Amino Acids; Anticarcinogenic Agents; Antineoplastic Agents; Bile Acids and Salts; Breast Neoplasms; Carnitine; Cell Cycle; Collagen; Cyclin D1; Cyclohexenes; Female; Gas Chromatography-Mass Spectrometry; Glucose; Humans; Limonene; Metabolome; Metabolomics; Plasma; Terpenes | 2015 |
Newborn screening for medium chain acyl-CoA dehydrogenase deficiency: performance improvement by monitoring a new ratio.
Topics: Acyl-CoA Dehydrogenase; Acyl-CoA Dehydrogenases; Biomarkers; Carnitine; False Positive Reactions; Heterozygote; Humans; Infant; Infant, Newborn; Infant, Very Low Birth Weight; Lipid Metabolism, Inborn Errors; Neonatal Screening; United States | 2014 |
Carnitine-acylcarnitine translocase deficiency: Two neonatal cases with common splicing mutation and in vitro bezafibrate response.
Topics: Bezafibrate; Carnitine; Carnitine Acyltransferases; Cells, Cultured; Child, Preschool; Fatal Outcome; Female; Fibroblasts; Genes, Lethal; Humans; Hypolipidemic Agents; In Vitro Techniques; Infant; Infant, Newborn; Lipid Metabolism, Inborn Errors; Male; Membrane Transport Proteins; Mitochondrial Diseases; Mutation; Treatment Outcome | 2015 |
Mitochondrial remodeling in mice with cardiomyocyte-specific lipid overload.
Topics: Adenosine Triphosphate; Animals; Carnitine; Catalase; Ceramides; Cyclic AMP Response Element-Binding Protein; Diglycerides; Electron Transport Complex II; Fatty Acid Transport Proteins; Gene Expression Regulation; Hydrogen Peroxide; Lipids; Mice; Mitochondria, Heart; Models, Biological; Myocardium; Myocytes, Cardiac; Organ Specificity; Oxygen Consumption; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; Phosphorylation; PPAR alpha; Protein Kinase C; Proto-Oncogene Proteins c-akt; RNA, Messenger; Sphingomyelins; Transcription Factors | 2015 |
Fiber-type-specific sensitivities and phenotypic adaptations to dietary fat overload differentially impact fast- versus slow-twitch muscle contractile function in C57BL/6J mice.
Topics: Acyl-CoA Dehydrogenase; Allostasis; Animals; Carnitine; Diet, Fat-Restricted; Diet, High-Fat; Electron Transport Chain Complex Proteins; Fatty Acids; Glycogen; Male; Mice, Inbred C57BL; Mitochondria, Muscle; Muscle Contraction; Muscle Fibers, Fast-Twitch; Muscle Fibers, Slow-Twitch; Muscle Relaxation; Obesity; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; Random Allocation; Transcription Factors; Troponin T | 2015 |
In HepG2 cells, coexisting carnitine deficiency masks important indicators of marginal biotin deficiency.
Topics: Acyl Coenzyme A; Biomarkers; Biotin; Carnitine; Chromatography, Liquid; Culture Media; False Negative Reactions; Female; Hep G2 Cells; Humans; Pregnancy; Tandem Mass Spectrometry | 2015 |
Sodium butyrate epigenetically modulates high-fat diet-induced skeletal muscle mitochondrial adaptation, obesity and insulin resistance through nucleosome positioning.
Topics: Adaptation, Physiological; Adiposity; Animals; Blood Glucose; Body Weight; Butyric Acid; Carnitine; Diet, High-Fat; Eating; Energy Metabolism; Epigenesis, Genetic; Insulin Resistance; Mice; Mice, Inbred C57BL; Mitochondria; Mitochondria, Muscle; Muscle Fibers, Slow-Twitch; Muscle, Skeletal; Nucleosomes; Obesity | 2015 |
An audit of newborn screening procedure: impact on infants presenting clinically before results are available.
Topics: Amino Acid Metabolism, Inborn Errors; Australia; Carnitine; Female; Health Personnel; Humans; Infant, Newborn; Lipid Metabolism, Inborn Errors; Male; Medical Audit; Neonatal Screening; Retrospective Studies; Tandem Mass Spectrometry; Time Factors | 2015 |
Carnitine supplementation alleviates lipid metabolism derangements and protects against oxidative stress in non-obese hereditary hypertriglyceridemic rats.
Topics: Animals; Carnitine; Dietary Supplements; DNA, Mitochondrial; Gene Expression Regulation; Genetic Predisposition to Disease; Homeostasis; Hypertriglyceridemia; Insulin Resistance; Kidney; Lipid Metabolism; Liver; Male; Muscle, Skeletal; Oxidative Stress; Rats | 2015 |
Lipid mediators of inflammation as novel plasma biomarkers to identify patients with bacteremia.
Topics: Adult; Aged; Aged, 80 and over; Bacteremia; Biomarkers; Carnitine; Chromatography, High Pressure Liquid; Fatty Acids; Female; Humans; Inflammation Mediators; Lipids; Male; Metabolomics; Middle Aged; Prognosis; ROC Curve; Sphingolipids | 2015 |
Strategies for correcting very long chain acyl-CoA dehydrogenase deficiency.
Topics: Acetylcysteine; Acyl-CoA Dehydrogenase; Acyl-CoA Dehydrogenase, Long-Chain; Amino Acid Sequence; Carnitine; Congenital Bone Marrow Failure Syndromes; Cysteine; Dose-Response Relationship, Drug; Fatty Acids; Fibroblasts; Genetic Therapy; Humans; Kinetics; Lipid Metabolism, Inborn Errors; Mitochondrial Diseases; Molecular Sequence Data; Muscular Diseases; Mutation; Oxidation-Reduction; Primary Cell Culture; Skin | 2015 |
[Acute encephalopathy induced by vaccination in an infant with methylmalonic aciduria cblA].
Topics: Amino Acid Metabolism, Inborn Errors; Brain Diseases; Carnitine; Diet, Protein-Restricted; Hepatitis B Vaccines; Humans; Infant; Male; Methylmalonic Acid; Mutation; Vaccination; Vitamin B Complex; Vomiting | 2015 |
Determination of carnitine and acylcarnitines in human urine by means of microextraction in packed sorbent and hydrophilic interaction chromatography-ultra-high-performance liquid chromatography-tandem mass spectrometry.
Topics: Biomarkers; Calibration; Carnitine; Chromatography, High Pressure Liquid; Humans; Hydrophobic and Hydrophilic Interactions; Indicators and Reagents; Quality Control; Reference Standards; Reproducibility of Results; Solid Phase Microextraction; Tandem Mass Spectrometry | 2015 |
Urinary F2-isoprostanes and metabolic markers of fat oxidation.
Topics: Carnitine; Chromatography, High Pressure Liquid; Cross-Sectional Studies; Diabetes Mellitus, Type 2; F2-Isoprostanes; Fatty Acids; Female; Humans; Logistic Models; Male; Middle Aged; Odds Ratio; Oxidation-Reduction; Risk Factors; Tandem Mass Spectrometry | 2015 |
A case of sudden death after Japanese encephalitis vaccination.
Topics: Anaphylaxis; Arrhythmias, Cardiac; Autopsy; C-Reactive Protein; Carnitine; Cause of Death; Child; Death, Sudden; Encephalitis, Japanese; Fatal Outcome; Heart Arrest; Humans; Japanese Encephalitis Vaccines; Male; Non-alcoholic Fatty Liver Disease; Psychotropic Drugs; Tandem Mass Spectrometry; Uncertainty | 2015 |
Multiple acyl-CoA dehydrogenation deficiency as decreased acyl-carnitine profile in serum.
Topics: Acyl Coenzyme A; Carnitine; DNA Mutational Analysis; Electron-Transferring Flavoproteins; Humans; Iron-Sulfur Proteins; Male; Multiple Acyl Coenzyme A Dehydrogenase Deficiency; Muscle, Skeletal; Mutation; Oxidoreductases Acting on CH-NH Group Donors; Young Adult | 2015 |
Acylcarnitine ester utilization by the hindlimb of warmblood horses at rest and following low intensity exercise and carnitine supplementation.
Topics: Animals; Carnitine; Dietary Supplements; Female; Hindlimb; Horses; Linear Models; Mass Spectrometry; Motor Activity; Rest | 2015 |
A heterozygous missense mutation in adolescent-onset very long-chain acyl-CoA dehydrogenase deficiency with exercise-induced rhabdomyolysis.
Topics: Acyl-CoA Dehydrogenase, Long-Chain; Adolescent; Amino Acid Sequence; Base Sequence; Carnitine; Congenital Bone Marrow Failure Syndromes; Exercise; Heterozygote; Humans; Infant, Newborn; Lipid Metabolism, Inborn Errors; Male; Mitochondrial Diseases; Models, Molecular; Molecular Sequence Data; Muscular Diseases; Mutation, Missense; Protein Structure, Tertiary; Rhabdomyolysis; Sequence Alignment | 2015 |
Long-chain acylcarnitines activate cell stress and myokine release in C2C12 myotubes: calcium-dependent and -independent effects.
Topics: Animals; Calcium; Carnitine; Cell Death; Cell Line; Dose-Response Relationship, Drug; Endoplasmic Reticulum Stress; Interleukin-6; MAP Kinase Signaling System; Mice; Muscle Fibers, Skeletal; Stress, Physiological; Structure-Activity Relationship | 2015 |
Metabolomic analysis reveals altered skeletal muscle amino acid and fatty acid handling in obese humans.
Topics: Adult; Amino Acids; Carnitine; Diet, High-Fat; Energy Metabolism; Fatty Acids; Humans; Lipid Metabolism; Male; Metabolomics; Muscle, Skeletal; Obesity; Oxidation-Reduction; Postprandial Period | 2015 |
Medium-chain dicarboxylic acylcarnitines as markers of n-3 PUFA-induced peroxisomal oxidation of fatty acids.
Topics: Animals; Biomarkers; Carnitine; Diet, High-Fat; Dietary Fats; Dietary Fats, Unsaturated; Fatty Acids, Omega-3; Fish Oils; Gene Expression Regulation; Glucose Intolerance; Hyperlipidemias; Liver; Male; Mice, Inbred C57BL; Molecular Weight; Overweight; Oxidation-Reduction; Peroxisome Proliferators; Peroxisomes; Pyrimidines | 2015 |
Altered Monoamine and Acylcarnitine Metabolites in HIV-Positive and HIV-Negative Subjects With Depression.
Topics: Adult; Biogenic Monoamines; Carnitine; Cohort Studies; Depression; Female; HIV Infections; Humans; Male; Metabolome; Middle Aged; Plasma | 2015 |
Dynamic biological changes in metabolic disease biomarkers in childhood and adolescence: A CALIPER study of healthy community children.
Topics: Adolescent; Amino Acids; Biomarkers; Carnitine; Child; Child, Preschool; Cohort Studies; Female; Health; Humans; Infant, Newborn; Male; Metabolism, Inborn Errors; Reference Values; Residence Characteristics; Young Adult | 2015 |
Neonatal Intrahepatic Cholestasis Caused by Citrin Deficiency Differentiated from Biliary Atresia.
Topics: Amino Acids; Analysis of Variance; Biliary Atresia; Bilirubin; Calcium-Binding Proteins; Carnitine; Case-Control Studies; Cholestasis, Intrahepatic; Hexoses; Humans; Infant; Infant, Newborn; Organic Anion Transporters; Retrospective Studies; Sensitivity and Specificity; Tandem Mass Spectrometry | 2016 |
Methyl-γ-butyrobetaine decreases levels of acylcarnitines and attenuates the development of atherosclerosis.
Topics: Animals; Aorta; Apolipoproteins E; Atherosclerosis; Betaine; Carnitine; Disease Progression; Female; Male; Mice | 2015 |
Transorgan fluxes in a porcine model reveal a central role for liver in acylcarnitine metabolism.
Topics: Acetylcarnitine; Animals; Carnitine; Catheters, Indwelling; Crosses, Genetic; Female; Intestinal Mucosa; Intestines; Kidney; Lipid Metabolism; Liver; Models, Biological; Olive Oil; Organ Specificity; Palmitoylcarnitine; Plant Oils; Postprandial Period; Sus scrofa | 2015 |
Inherited metabolic disorders in Turkish patients with autism spectrum disorders.
Topics: Adolescent; Adult; Amino Acids; Ammonia; Autism Spectrum Disorder; Blood Gas Analysis; Carnitine; Child; Child, Preschool; Comorbidity; Female; Glycosaminoglycans; Homocysteine; Humans; Infant; Lactic Acid; Male; Metabolism, Inborn Errors; Prevalence; Retrospective Studies; Tandem Mass Spectrometry; Turkey; Young Adult | 2016 |
Metabolism alteration in follicular niche: The nexus among intermediary metabolism, mitochondrial function, and classic polycystic ovary syndrome.
Topics: Adult; Amino Acids, Branched-Chain; Carnitine; Case-Control Studies; Female; Glycolysis; Humans; Ketone Bodies; Mitochondria; Mitophagy; Organelle Biogenesis; Ovarian Follicle; Oxidation-Reduction; Oxidative Stress; Polycystic Ovary Syndrome; Pregnancy; Pregnancy Rate; Reproductive Techniques, Assisted; Treatment Outcome | 2015 |
Female and male human babies have distinct blood metabolomic patterns.
Topics: Age Factors; Amino Acids; Carnitine; Dried Blood Spot Testing; Female; Humans; Infant; Infant, Newborn; Male; Metabolome; Metabolomics; Sex Factors; Tandem Mass Spectrometry | 2015 |
First-Trimester Serum Acylcarnitine Levels to Predict Preeclampsia: A Metabolomics Approach.
Topics: Adult; Biomarkers; Carnitine; Case-Control Studies; Female; Humans; Metabolomics; Pre-Eclampsia; Pregnancy; Pregnancy Trimester, First; Tandem Mass Spectrometry | 2015 |
Carnitine Acetyltransferase Mitigates Metabolic Inertia and Muscle Fatigue during Exercise.
Topics: Acetyl Coenzyme A; Animals; Carnitine; Carnitine O-Acetyltransferase; Exercise; Humans; Mice, Inbred C57BL; Muscle Fatigue; Muscles; Physical Conditioning, Animal | 2015 |
Effects of waterborne copper exposure on carnitine composition, kinetics of carnitine palmitoyltransferases I (CPT I) and mRNA levels of CPT I isoforms in yellow catfish Pelteobagrus fulvidraco.
Topics: Animals; Carnitine; Carnitine O-Palmitoyltransferase; Catfishes; Copper; Environmental Monitoring; Isoenzymes; Kinetics; Lipid Metabolism; Liver; Muscles; RNA, Messenger; Water Pollutants, Chemical | 2015 |
Acylcarnitines are anticoagulants that inhibit factor Xa and are reduced in venous thrombosis, based on metabolomics data.
Topics: Adult; Aged; Aged, 80 and over; Anticoagulants; Carnitine; Case-Control Studies; Factor Xa; Factor Xa Inhibitors; Female; Humans; Male; Metabolomics; Middle Aged; Protein Binding; Protein Structure, Tertiary; Risk Factors; Venous Thrombosis; Warfarin | 2015 |
Undernutrition during pregnancy in mice leads to dysfunctional cardiac muscle respiration in adult offspring.
Topics: Animals; Birth Weight; Carnitine; Energy Metabolism; Female; Heart; Liver; Malnutrition; Mice, Inbred ICR; Mitochondria, Heart; Myocardium; Pregnancy; Prenatal Nutritional Physiological Phenomena | 2015 |
An LC-MS/MS method to quantify acylcarnitine species including isomeric and odd-numbered forms in plasma and tissues.
Topics: Amino Acids; Animals; Carnitine; Chromatography, Liquid; Diabetes Mellitus, Experimental; Fatty Acids; Isomerism; Liver; Mice; Mice, Inbred C57BL; Oxidation-Reduction; Tandem Mass Spectrometry | 2015 |
Long-chain Acylcarnitines Reduce Lung Function by Inhibiting Pulmonary Surfactant.
Topics: Acyl-CoA Dehydrogenase, Long-Chain; Animals; Carnitine; Humans; Lung; Lung Injury; Mice; Mice, Knockout; Phospholipids; Pulmonary Surfactants | 2015 |
Choline supplementation restores substrate balance and alleviates complications of Pcyt2 deficiency.
Topics: Acylation; Adipose Tissue; AMP-Activated Protein Kinases; Animals; Carnitine; Choline; Dietary Supplements; Fatty Acids; Gene Expression Regulation; Liver; Mice, Mutant Strains; Phosphatidylcholines; Phosphatidylserines; RNA Nucleotidyltransferases; Triglycerides; Weight Gain | 2015 |
Validated method for the quantification of free and total carnitine, butyrobetaine, and acylcarnitines in biological samples.
Topics: Animals; Betaine; Carnitine; Chromatography, High Pressure Liquid; Diabetes Mellitus, Experimental; Humans; Mesylates; Muscle, Skeletal; Rats; Solid Phase Extraction; Spectrometry, Mass, Electrospray Ionization; Trimethylsilyl Compounds | 2015 |
Carnitine supplementation in high-fat diet-fed rats does not ameliorate lipid-induced skeletal muscle mitochondrial dysfunction in vivo.
Topics: Animals; Carnitine; Diet, High-Fat; Dietary Supplements; Lipid Metabolism; Lipids; Male; Mitochondria, Muscle; Mitochondrial Diseases; Muscle, Skeletal; Rats; Rats, Wistar | 2015 |
Hypoglycin A Content in Blood and Urine Discriminates Horses with Atypical Myopathy from Clinically Normal Horses Grazing on the Same Pasture.
Topics: Acer; Animals; Carnitine; Disease Outbreaks; Horse Diseases; Horses; Hypoglycins; Muscular Diseases; Plant Poisoning; Plants, Toxic; Seeds; Tandem Mass Spectrometry | 2015 |
Recurrent ACADVL molecular findings in individuals with a positive newborn screen for very long chain acyl-coA dehydrogenase (VLCAD) deficiency in the United States.
Topics: Acyl-CoA Dehydrogenase, Long-Chain; Alleles; Carnitine; Computer Simulation; Congenital Bone Marrow Failure Syndromes; Exons; Female; Genetic Carrier Screening; Genotype; Humans; Hypoglycemia; Infant, Newborn; Lipid Metabolism, Inborn Errors; Male; Mitochondrial Diseases; Muscular Diseases; Mutation, Missense; Neonatal Screening; Oligonucleotide Array Sequence Analysis; Sequence Analysis, DNA; Tandem Mass Spectrometry; United States | 2015 |
Integration of Genome-Wide SNP Data and Gene-Expression Profiles Reveals Six Novel Loci and Regulatory Mechanisms for Amino Acids and Acylcarnitines in Whole Blood.
Topics: Amino Acids; Carnitine; Cohort Studies; Disease; Gene Expression Profiling; Genome-Wide Association Study; Humans; Polymorphism, Single Nucleotide; Quantitative Trait Loci | 2015 |
Clinical, biochemical and molecular investigation of adult-onset glutaric acidemia type II: Characteristics in comparison with pediatric cases.
Topics: Adult; Age Factors; Carnitine; Humans; Male; Multiple Acyl Coenzyme A Dehydrogenase Deficiency; Muscle Weakness; Muscular Diseases | 2016 |
Reference values for amino acids and acylcarnitines in peripheral blood in Quarter horses and American Miniature horses.
Topics: Amino Acids; Animals; Carnitine; Female; Horses; Male; Mexico; Reference Values; Tandem Mass Spectrometry | 2015 |
Elevation of pivaloylcarnitine by sivelestat sodium in two children.
Topics: Amino Acid Metabolism, Inborn Errors; Cardiomyopathies; Carnitine; Child, Preschool; Chromatography, Liquid; Female; Glycine; Humans; Hyperammonemia; Infant, Newborn; Isovaleryl-CoA Dehydrogenase; Muscular Diseases; Neonatal Screening; Serine Proteinase Inhibitors; Sulfonamides; Tandem Mass Spectrometry | 2015 |
Simultaneous quantitation of hexacosanoyl lysophosphatidylcholine, amino acids, acylcarnitines, and succinylacetone during FIA-ESI-MS/MS analysis of dried blood spot extracts for newborn screening.
Topics: Calibration; Carnitine; Chromatography, High Pressure Liquid; Flow Injection Analysis; Heptanoates; Humans; Infant, Newborn; Lysophosphatidylcholines; Neonatal Screening; Quality Control; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry | 2016 |
Quantitative acylcarnitine determination by UHPLC-MS/MS--Going beyond tandem MS acylcarnitine "profiles".
Topics: Acetyl-CoA C-Acyltransferase; Acyl-CoA Dehydrogenase; Amino Acid Metabolism, Inborn Errors; Betaine; Carbon-Carbon Ligases; Carnitine; Chromatography, High Pressure Liquid; Female; Humans; Infant, Newborn; Isomerism; Lipid Metabolism, Inborn Errors; Male; Neonatal Screening; Reproducibility of Results; Sensitivity and Specificity; Tandem Mass Spectrometry; Urea Cycle Disorders, Inborn | 2015 |
Metabolic Dysfunction Is Restricted to the Sciatic Nerve in Experimental Diabetic Neuropathy.
Topics: Animals; Carnitine; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Disease Models, Animal; Energy Metabolism; Fructose; Ganglia, Spinal; Glucose; Homeostasis; Inositol; Lipid Metabolism; Lumbar Vertebrae; Metabolomics; Mitochondria; Neural Conduction; Oxidative Phosphorylation; Oxidative Stress; Polymers; Rats; Rats, Sprague-Dawley; Sciatic Nerve; Sorbitol; Trigeminal Ganglion | 2016 |
Accurate prediction of gestational age using newborn screening analyte data.
Topics: 17-alpha-Hydroxyprogesterone; Algorithms; Amino Acids; Biomarkers; Biotinidase; Birth Weight; Carnitine; Cross-Sectional Studies; Fatty Acids; Female; Gestational Age; Humans; Infant, Newborn; Logistic Models; Male; Neonatal Screening; Ontario; Oxidation-Reduction; Pregnancy; Thyrotropin; UTP-Hexose-1-Phosphate Uridylyltransferase | 2016 |
Metabolomic Quantitative Trait Loci (mQTL) Mapping Implicates the Ubiquitin Proteasome System in Cardiovascular Disease Pathogenesis.
Topics: Cardiovascular Diseases; Carnitine; DNA Methylation; Endoplasmic Reticulum Stress; Humans; Metabolomics; Polymorphism, Single Nucleotide; Proteasome Endopeptidase Complex; Quantitative Trait Loci; Risk Factors; Ubiquitin | 2015 |
Anaplerotic treatment of long-chain fat oxidation disorders with triheptanoin: Review of 15 years Experience.
Topics: Administration, Oral; Adolescent; Adult; Carnitine; Child; Child, Preschool; Citric Acid; Fatty Acids; Female; Humans; Infant; Infant, Newborn; Lactic Acid; Lipid Metabolism, Inborn Errors; Malates; Male; Middle Aged; Mitochondrial Diseases; Oxidation-Reduction; Succinic Acid; Survival Analysis; Treatment Outcome; Triglycerides | 2015 |
Acylcarnitine Profiles in HIV-Exposed, Uninfected Neonates in the United States.
Topics: Adult; Anti-HIV Agents; Carnitine; Child Development; Child, Preschool; Cohort Studies; Female; HIV Infections; Humans; Infant; Infant, Newborn; Male; Maternal Exposure; Pregnancy; Pregnancy Complications, Infectious; United States; Young Adult | 2016 |
MK2 Deletion in Mice Prevents Diabetes-Induced Perturbations in Lipid Metabolism and Cardiac Dysfunction.
Topics: Animals; Carnitine; Diabetes Mellitus, Experimental; Diabetic Cardiomyopathies; Fatty Acids, Nonesterified; Gene Deletion; Hyperglycemia; Insulin; Insulin Resistance; Intracellular Signaling Peptides and Proteins; Ketone Bodies; Lipid Metabolism; Mice; Muscle Contraction; Protein Serine-Threonine Kinases; Streptozocin; Triglycerides | 2016 |
Kinetic and molecular orbital analyses of dicarboxylic acylcarnitine methylesterification show that derivatization may affect the screening of newborns by tandem mass spectrometry.
Topics: Carnitine; Dicarboxylic Acids; Esterification; Humans; Infant, Newborn; Kinetics; Methylation; Molecular Structure; Neonatal Screening; Quantum Theory; Tandem Mass Spectrometry | 2016 |
Elevations of C14:1 and C14:2 Plasma Acylcarnitines in Fasted Children: A Diagnostic Dilemma.
Topics: Acyl-CoA Dehydrogenase, Long-Chain; Adolescent; Carnitine; Child; Child, Preschool; Congenital Bone Marrow Failure Syndromes; Fasting; Female; Humans; Infant; Lipid Metabolism, Inborn Errors; Male; Mitochondrial Diseases; Muscular Diseases; Retrospective Studies | 2016 |
Quantification of Free Carnitine and Acylcarnitines in Plasma or Serum Using HPLC/MS/MS.
Topics: Blood Chemical Analysis; Carnitine; Chromatography, High Pressure Liquid; Humans; Reference Standards; Tandem Mass Spectrometry | 2016 |
Decreased acylcarnitine content improves insulin sensitivity in experimental mice models of insulin resistance.
Topics: Animals; Blood Glucose; Carnitine; Diabetes Mellitus; Diabetes Mellitus, Experimental; Diet, High-Fat; Disease Models, Animal; Fatty Acids; gamma-Aminobutyric Acid; Gene Expression; Glucose; Insulin; Insulin Resistance; Lipid Metabolism; Male; Mice; Mice, Inbred C57BL; Muscles; Physical Conditioning, Animal; PPAR alpha; Quaternary Ammonium Compounds; Signal Transduction | 2016 |
Predicting gestational age using neonatal metabolic markers.
Topics: 17-alpha-Hydroxyprogesterone; Amino Acids; Biomarkers; Birth Weight; Carnitine; Fatty Acids; Female; Gestational Age; Humans; Infant, Newborn; Logistic Models; Male; Neonatal Screening; Pregnancy; Retrospective Studies; Thyrotropin; UTP-Hexose-1-Phosphate Uridylyltransferase | 2016 |
Metabolic changes in serum metabolome in response to a meal.
Topics: Aged; Amino Acids; Blood Glucose; Bread; Carnitine; Dietary Carbohydrates; Dietary Fats; Dietary Fiber; Dietary Proteins; Energy Metabolism; Fasting; Female; Glycolysis; Humans; Insulin; Ketone Bodies; Leucine; Meals; Metabolome; Middle Aged; Phospholipids; Postmenopause; Postprandial Period; Triticum | 2017 |
Gestational dating by metabolic profile at birth: a California cohort study.
Topics: 17-alpha-Hydroxyprogesterone; Algorithms; Amino Acids; Biomarkers; California; Carnitine; Cohort Studies; Discriminant Analysis; Female; Gestational Age; Humans; Infant, Newborn; Male; Metabolomics; Multivariate Analysis; Pregnancy; Thyrotropin; Ultrasonography, Prenatal; UTP-Hexose-1-Phosphate Uridylyltransferase | 2016 |
Longitudinal Metabolomic Profiling of Amino Acids and Lipids across Healthy Pregnancy.
Topics: Acetylcarnitine; Adult; Amino Acids; Carnitine; Citric Acid Cycle; Fasting; Fatty Acids; Female; Humans; Lipid Metabolism; Lipids; Longitudinal Studies; Metabolomics; Oxidation-Reduction; Placenta; Pregnancy; Prospective Studies | 2015 |
Simultaneous quantification of cardiovascular disease related metabolic risk factors using liquid chromatography tandem mass spectrometry in human serum.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Amino Acids; Cardiovascular Diseases; Carnitine; Chromatography, Liquid; Female; Humans; Male; Metabolome; Metabolomics; Middle Aged; Risk Factors; Tandem Mass Spectrometry; Young Adult | 2016 |
Acylcarnitines participate in developmental processes associated to lipid metabolism in plants.
Topics: Acyl Coenzyme A; Arabidopsis; Arabidopsis Proteins; Brassica napus; Carnitine; Gene Expression Regulation, Plant; Germination; Lipid Metabolism; Plants; Seeds | 2016 |
Lipotoxicity in steatohepatitis occurs despite an increase in tricarboxylic acid cycle activity.
Topics: Animals; Carbon Isotopes; Carnitine; Ceramides; Chromatography, Liquid; Citric Acid Cycle; Dietary Fats; Dietary Sucrose; Diglycerides; Disease Models, Animal; Fatty Acids, Nonesterified; Fructose; Glucose Clamp Technique; Inflammation; Insulin Resistance; Liver; Magnetic Resonance Spectroscopy; Metabolome; Mice; Mitochondria, Liver; Non-alcoholic Fatty Liver Disease; Oxidation-Reduction; Real-Time Polymerase Chain Reaction; RNA, Messenger; Severity of Illness Index; Tandem Mass Spectrometry; Trans Fatty Acids; Transcriptome | 2016 |
Higher plasma levels of lysophosphatidylcholine 18:0 are related to a lower risk of common cancers in a prospective metabolomics study.
Topics: Biomarkers, Tumor; Breast Neoplasms; Carnitine; Cohort Studies; Colorectal Neoplasms; Female; Humans; Lipid Metabolism; Lipids; Lysophosphatidylcholines; Male; Middle Aged; Neoplasms; Prospective Studies; Prostatic Neoplasms | 2016 |
Alzheimer's disease-like pathology has transient effects on the brain and blood metabolome.
Topics: Aging; Alzheimer Disease; Amino Acids, Branched-Chain; Amino Acids, Essential; Animals; Biogenic Polyamines; Brain; Carnitine; Disease Models, Animal; Male; Metabolome; Mice, Transgenic; Phospholipids; Serotonin | 2016 |
Longitudinal metabolic imaging of hepatocellular carcinoma in transgenic mouse models identifies acylcarnitine as a potential biomarker for early detection.
Topics: Animals; Biomarkers; Carcinoma, Hepatocellular; Carnitine; Diffusion Magnetic Resonance Imaging; Disease Models, Animal; Early Detection of Cancer; Gene Expression Profiling; Humans; Liver Neoplasms; Mice; Mice, Transgenic; Molecular Imaging; Tumor Burden | 2016 |
Absolute and Relative Carnitine Deficiency in Patients on Hemodialysis and Peritoneal Dialysis.
Topics: Adolescent; Blood Urea Nitrogen; Carnitine; Child; Female; Humans; Male; Peritoneal Dialysis, Continuous Ambulatory; Renal Dialysis; Renal Insufficiency, Chronic; Young Adult | 2016 |
The Gut Microbiota Modulates Energy Metabolism in the Hibernating Brown Bear Ursus arctos.
Topics: Actinobacteria; Adaptation, Physiological; Adiposity; Animals; Bacteroidetes; Bile Acids and Salts; Blood Glucose; Carnitine; Cholesterol; Energy Metabolism; Fecal Microbiota Transplantation; Feces; Firmicutes; Gastrointestinal Microbiome; Germ-Free Life; Hibernation; Mice; Principal Component Analysis; Seasons; Triglycerides; Ursidae | 2016 |
Metabolomics Study of Roux-en-Y Gastric Bypass Surgery (RYGB) to Treat Type 2 Diabetes Patients Based on Ultraperformance Liquid Chromatography-Mass Spectrometry.
Topics: Adult; Amino Acids; Bile Acids and Salts; Bilirubin; Biomarkers; Carnitine; Chromatography, High Pressure Liquid; Diabetes Mellitus, Type 2; Energy Metabolism; Fatty Acids, Nonesterified; Female; Gastric Bypass; Hippurates; Humans; Indican; Insulin Resistance; Male; Mass Spectrometry; Metabolomics; Middle Aged; Obesity, Morbid; Oxidative Stress; Prognosis; Remission Induction; Treatment Outcome; Tryptophan; Weight Loss | 2016 |
Unique plasma metabolomic signatures of individuals with inherited disorders of long-chain fatty acid oxidation.
Topics: Acyl-CoA Dehydrogenase, Long-Chain; Adolescent; Carnitine; Carnitine O-Palmitoyltransferase; Case-Control Studies; Ceramides; Fatty Acids; Female; Humans; Lipid Metabolism; Lipid Metabolism, Inborn Errors; Male; Metabolic Networks and Pathways; Metabolism, Inborn Errors; Oxidation-Reduction; Phosphatidylcholines; Phosphatidylethanolamines; Plasma; Sphingomyelins; Triglycerides | 2016 |
Low levels of short- and medium-chain acylcarnitines in HIV-infected patients.
Topics: Adult; Antiretroviral Therapy, Highly Active; Carnitine; Case-Control Studies; Disease Progression; Female; HIV Infections; Humans; Interferon-gamma; Interferon-gamma Release Tests; Longitudinal Studies; Male; Mycobacterium avium Complex; Mycobacterium avium-intracellulare Infection; Tumor Necrosis Factor-alpha | 2016 |
Muscle and liver-specific alterations in lipid and acylcarnitine metabolism after a single bout of exercise in mice.
Topics: Animals; Carnitine; Glycolysis; Lipid Metabolism; Liver; Lysophospholipids; Mice; Muscle, Skeletal; Organ Specificity; Oxidation-Reduction; Physical Conditioning, Animal; Plasmalogens | 2016 |
Altered levels of acylcarnitines, phosphatidylcholines, and sphingomyelins in peritoneal fluid from ovarian endometriosis patients.
Topics: Adult; Area Under Curve; Biomarkers; Carnitine; Case-Control Studies; Endometriosis; Female; Humans; Peritoneum; Phosphatidylcholines; ROC Curve; Sphingomyelins | 2016 |
Metabolomic Profiling of Plasma from Melioidosis Patients Using UHPLC-QTOF MS Reveals Novel Biomarkers for Diagnosis.
Topics: Bacteremia; Biomarkers; Carnitine; Case-Control Studies; Humans; Melioidosis; Metabolome; Phosphatidylcholines; Sphingomyelins | 2016 |
Long-chain acylcarnitines determine ischaemia/reperfusion-induced damage in heart mitochondria.
Topics: Animals; Carnitine; Carnitine O-Palmitoyltransferase; Male; Mitochondria, Heart; Myocardial Reperfusion Injury; Oxidative Phosphorylation; Rats; Rats, Wistar | 2016 |
To treat or not to treat: metabolomics reveals biomarkers for treatment indication in chronic lymphocytic leukaemia patients.
Topics: Biomarkers, Tumor; Carnitine; Female; Humans; Leukemia, Lymphocytic, Chronic, B-Cell; Linoleic Acids; Male; Metabolomics; Middle Aged | 2016 |
High incorporation of long-chain fatty acids contributes to the efficient production of acylated ghrelin in ghrelin-producing cells.
Topics: Acylation; Acyltransferases; Animals; Carnitine; Cell Line; Coenzyme A Ligases; Enteroendocrine Cells; Enzyme Inhibitors; Fatty Acids, Nonesterified; Gene Expression Profiling; Gene Expression Regulation; Ghrelin; Insulin-Secreting Cells; Lipoylation; Membrane Proteins; Mice, Transgenic; Molecular Weight; Protein Processing, Post-Translational; Recombinant Fusion Proteins; RNA Interference; Triazenes | 2016 |
Significant clinical heterogeneity with similar ETFDH genotype in three Chinese patients with late-onset multiple acyl-CoA dehydrogenase deficiency.
Topics: Adolescent; Adult; Aged; Carnitine; Computational Biology; DNA Mutational Analysis; Electron-Transferring Flavoproteins; Genotype; Humans; Iron-Sulfur Proteins; Magnetic Resonance Imaging; Male; Multiple Acyl Coenzyme A Dehydrogenase Deficiency; Muscle Weakness; Muscular Diseases; Mutation; Oxidoreductases Acting on CH-NH Group Donors | 2016 |
Multiple acyl-CoA dehydrogenase deficiency (MADD) as a cause of late-onset treatable metabolic disease.
Topics: Adult; Age of Onset; Biopsy; Carnitine; Electromyography; Electron-Transferring Flavoproteins; Exercise; Female; France; Humans; Iron-Sulfur Proteins; Lipid Metabolism, Inborn Errors; Male; Middle Aged; Multiple Acyl Coenzyme A Dehydrogenase Deficiency; Muscle, Skeletal; Mutation; Neuromuscular Diseases; Oxidation-Reduction; Oxidoreductases Acting on CH-NH Group Donors; Rhabdomyolysis; Young Adult | 2016 |
Systems biology analysis of hepatitis C virus infection reveals the role of copy number increases in regions of chromosome 1q in hepatocellular carcinoma metabolism.
Topics: Acyl Coenzyme A; Acyltransferases; Carcinoma, Hepatocellular; Carnitine; Chromosomes, Human, Pair 1; Collagen; Diglycerides; DNA Copy Number Variations; Hepacivirus; Hepatitis C; Humans; Keratan Sulfate; Lipid Metabolism; Liver Cirrhosis; Liver Neoplasms; Models, Biological; S-Adenosylmethionine; Systems Biology; Transaminases; Virus Assembly | 2016 |
Clinical Features of Carnitine Deficiency Secondary to Pivalate-Conjugated Antibiotic Therapy.
Topics: Adolescent; Adult; Anti-Bacterial Agents; Brain Diseases; Carnitine; Child; Child, Preschool; Female; Humans; Hypoglycemia; Infant; Male; Retrospective Studies; Tandem Mass Spectrometry; Young Adult | 2016 |
The impact of altered carnitine availability on acylcarnitine metabolism, energy expenditure and glucose tolerance in diet-induced obese mice.
Topics: Animals; Betaine; Carnitine; Dietary Fats; Energy Metabolism; Glucose Intolerance; Insulin Resistance; Liver; Mice; Mice, Obese; Muscle, Skeletal; Obesity | 2016 |
Metabolomic Research on Newborn Infants With Intrauterine Growth Restriction.
Topics: Amino Acids; Carnitine; Female; Fetal Growth Retardation; Gestational Age; Humans; Infant, Newborn; Intensive Care Units, Neonatal; Male; Metabolic Diseases; Metabolomics; Neonatal Screening; Reference Values; Research | 2016 |
C26:0-Carnitine Is a New Biomarker for X-Linked Adrenoleukodystrophy in Mice and Man.
Topics: Acetyltransferases; Adrenoleukodystrophy; Animals; ATP Binding Cassette Transporter, Subfamily D, Member 1; ATP-Binding Cassette Transporters; Biomarkers; Brain; Carnitine; Early Diagnosis; Fatty Acid Elongases; Fatty Acids; Gene Knock-In Techniques; Humans; Lysophosphatidylcholines; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Oligodendroglia; Spinal Cord | 2016 |
Simultaneous determination of thirteen kinds of amino acid and eight kinds of acylcarnitine in human serum by LC-MS/MS and its application to measure the serum concentration of lung cancer patients.
Topics: Aged; Aged, 80 and over; Amino Acids; Carnitine; Chromatography, High Pressure Liquid; Female; Humans; Limit of Detection; Lung Neoplasms; Male; Middle Aged; Tandem Mass Spectrometry | 2016 |
Influence of moderate maternal nutrition restriction on the fetal baboon metabolome at 0.5 and 0.9 gestation.
Topics: Adaptation, Physiological; Animals; Biomarkers; Caloric Restriction; Carnitine; Chromatography, Liquid; Disease Models, Animal; Fatty Acids, Nonesterified; Female; Fetus; Gestational Age; Gluconeogenesis; Humans; Liver; Malnutrition; Mass Spectrometry; Maternal Nutritional Physiological Phenomena; Metabolome; Metabolomics; Papio; Phospholipids; Pregnancy | 2016 |
Superior Glucose Tolerance and Metabolomic Profiles, Independent of Adiposity, in HIV-Infected Women Compared With Men on Antiretroviral Therapy.
Topics: Absorptiometry, Photon; Adipose Tissue; Adiposity; Adult; Amino Acids, Branched-Chain; Anti-Retroviral Agents; Blood Glucose; Carnitine; Case-Control Studies; CD4 Lymphocyte Count; Diabetes Mellitus; Fasting; Female; HIV Infections; HIV Seronegativity; Humans; Insulin Resistance; Male; Metabolome; Middle Aged; Obesity; Regression Analysis; Reverse Transcriptase Inhibitors; Risk Factors; Sex Factors; Time Factors | 2016 |
Plasma Acylcarnitines and Amino Acid Levels As an Early Complex Biomarker of Propensity to High-Fat Diet-Induced Obesity in Mice.
Topics: Amino Acids; Analysis of Variance; Animals; Biomarkers; Blood Glucose; Carnitine; Cluster Analysis; Diet, High-Fat; Disease Models, Animal; Female; Glucose Intolerance; Glucose Tolerance Test; Insulin Resistance; Male; Metabolome; Metabolomics; Mice; Obesity; Phenotype; Prognosis; Propensity Score | 2016 |
Metabolic Pathway Signatures Associated with Urinary Metabolite Biomarkers Differentiate Bladder Cancer Patients from Healthy Controls.
Topics: Aged; Biomarkers; Carcinoma, Transitional Cell; Carnitine; Case-Control Studies; Female; Humans; Male; Metabolic Networks and Pathways; Middle Aged; Real-Time Polymerase Chain Reaction; RNA, Messenger; Urinary Bladder Neoplasms | 2016 |
Serum Levels of Acyl-Carnitines along the Continuum from Normal to Alzheimer's Dementia.
Topics: Aged; Alzheimer Disease; Analysis of Variance; Biomarkers; Body Mass Index; Calibration; Carnitine; Case-Control Studies; Cognition Disorders; Dementia; Female; Healthy Volunteers; Humans; Male; Middle Aged; Phenotype; Risk | 2016 |
Effect of Exercise and Calorie Restriction on Tissue Acylcarnitines, Tissue Desaturase Indices, and Fat Accumulation in Diet-Induced Obese Rats.
Topics: Animals; Caloric Restriction; Carnitine; Diet, High-Fat; Disease Models, Animal; Fatty Acid Desaturases; Humans; Insulin Resistance; Liver; Male; Muscle, Skeletal; Obesity; Physical Conditioning, Animal; Rats; Rats, Inbred F344; Treatment Outcome | 2016 |
Outcomes and genotype-phenotype correlations in 52 individuals with VLCAD deficiency diagnosed by NBS and enrolled in the IBEM-IS database.
Topics: Acyl-CoA Dehydrogenase, Long-Chain; Adolescent; Carnitine; Child; Child, Preschool; Congenital Bone Marrow Failure Syndromes; Creatine Kinase; Female; Genetic Association Studies; Genotype; Humans; Infant; Infant, Newborn; Lipid Metabolism, Inborn Errors; Male; Mitochondrial Diseases; Muscular Diseases; Mutation; Neonatal Screening; Retrospective Studies | 2016 |
Quantitative analysis of amino acids and acylcarnitines combined with untargeted metabolomics using ultra-high performance liquid chromatography and quadrupole time-of-flight mass spectrometry.
Topics: Aged; Amino Acids; Biomarkers; Carnitine; Chromatography, High Pressure Liquid; Female; Humans; Limit of Detection; Male; Metabolomics; Middle Aged; Spectrometry, Mass, Electrospray Ionization | 2016 |
Association between Metabolite Profiles, Metabolic Syndrome and Obesity Status.
Topics: Adult; Amino Acids; Body Mass Index; Cardiovascular Diseases; Carnitine; Cholesterol; Cholesterol, HDL; Female; Glycerophospholipids; Humans; Hyperlipidemias; Male; Metabolic Syndrome; Metabolomics; Middle Aged; Obesity; Overweight; Principal Component Analysis; Quebec; Risk Factors; Triglycerides; Waist Circumference | 2016 |
Medium-chain plasma acylcarnitines, ketone levels, cognition, and gray matter volumes in healthy elderly, mildly cognitively impaired, or Alzheimer's disease subjects.
Topics: Aged; Aging; Alzheimer Disease; Carnitine; Cognition; Cognitive Dysfunction; Cohort Studies; Female; Gray Matter; Humans; Hydroxybutyrates; Ketone Bodies; Male | 2016 |
Hepatic Fatty Acid Oxidation Restrains Systemic Catabolism during Starvation.
Topics: Adipose Tissue; Animals; Blood Glucose; Body Weight; Carnitine; Carnitine O-Palmitoyltransferase; Diet, Ketogenic; Dyslipidemias; Fasting; Fatty Acids; Gene Expression Regulation; Lipogenesis; Liver; Mice, Knockout; Organ Specificity; Oxidation-Reduction; Oxidative Stress; PPAR alpha; Starvation; Triglycerides | 2016 |
Fermentable soluble fibres spare amino acids in healthy dogs fed a low-protein diet.
Topics: Acetic Acid; Amino Acids; Animals; Carnitine; Cross-Over Studies; Diet; Dietary Fiber; Dogs; Fatty Acids, Volatile; Feces; Propionates; Random Allocation | 2016 |
Untargeted mass spectrometric approach in metabolic healthy offspring of patients with type 2 diabetes reveals medium-chain acylcarnitine as potential biomarker for lipid induced glucose intolerance (LGIT).
Topics: Adolescent; Adult; Aged; Biomarkers; Blood Glucose; Carnitine; Case-Control Studies; Chromatography, Liquid; Diabetes Mellitus, Type 2; Female; Glucose Intolerance; Glucose Tolerance Test; Humans; Lipids; Male; Mass Spectrometry; Metabolome; Middle Aged; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Young Adult | 2016 |
Mitochondrial function is altered in horse atypical myopathy.
Topics: Acer; Animal Feed; Animals; Carnitine; Europe; Female; Horse Diseases; Horses; Hypoglycins; Male; Mitochondrial Diseases; Muscles; Muscular Diseases; Oxidative Phosphorylation | 2016 |
Early Prediction of Developing Type 2 Diabetes by Plasma Acylcarnitines: A Population-Based Study.
Topics: Aged; Biomarkers; Blood Glucose; Carnitine; China; Chromatography, Liquid; Diabetes Mellitus, Type 2; Fasting; Female; Glycated Hemoglobin; Humans; Insulin; Lipid Metabolism; Logistic Models; Male; Metabolomics; Middle Aged; Mitochondria; Prospective Studies; Risk Factors; ROC Curve; Tandem Mass Spectrometry | 2016 |
2-Ethylhexanoic acid, found in common plasticizers, leads to an artificial increase in C8 acylcarnitine levels in two neonates treated with extracorporeal membrane oxygenation (ECMO).
Topics: Caproates; Carnitine; Extracorporeal Membrane Oxygenation; Humans; Infant, Newborn; Male; Plasticizers | 2016 |
Two transgenic mouse models for β-subunit components of succinate-CoA ligase yielding pleiotropic metabolic alterations.
Topics: Alleles; Animals; Blotting, Western; Carnitine; Cells, Cultured; DNA, Mitochondrial; Heterozygote; Humans; In Vitro Techniques; Membrane Potential, Mitochondrial; Mice; Mice, Knockout; Mice, Mutant Strains; Mitochondria; Phosphorylation; RNA, Messenger; Succinate-CoA Ligases | 2016 |
Efficacy of bezafibrate on fibroblasts of glutaric acidemia type II patients evaluated using an in vitro probe acylcarnitine assay.
Topics: Adolescent; Adult; Age of Onset; Bezafibrate; Carnitine; Cell Survival; Cells, Cultured; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Enzyme Activators; Female; Fibroblasts; Humans; Infant; Infant, Newborn; Lipid Regulating Agents; Male; Multiple Acyl Coenzyme A Dehydrogenase Deficiency; Palmitoylcarnitine; Peroxisome Proliferator-Activated Receptors; Skin | 2017 |
Aerobic capacity and hepatic mitochondrial lipid oxidation alters susceptibility for chronic high-fat diet-induced hepatic steatosis.
Topics: Aerobiosis; Animals; Carnitine; Citric Acid Cycle; Diet, High-Fat; Disease Susceptibility; Fatty Acids; Lipid Metabolism; Liver; Male; Mitochondria, Liver; Non-alcoholic Fatty Liver Disease; Oxidation-Reduction; Oxidative Stress; Pyruvic Acid; Rats; Triglycerides | 2016 |
Palmitoyl-carnitine production by blood cells associates with the concentration of circulating acyl-carnitines in healthy overweight women.
Topics: Adult; Aged; Blood Cells; Blood Glucose; Body Mass Index; Carnitine; Diabetes Mellitus, Type 2; Female; Humans; Hyperinsulinism; Insulin; Insulin Resistance; Lipid Metabolism; Middle Aged; Overweight; Oxidation-Reduction; Palmitates; Palmitoylcarnitine | 2017 |
Liver and Muscle Contribute Differently to the Plasma Acylcarnitine Pool During Fasting and Exercise in Humans.
Topics: Adult; Carnitine; Exercise; Fasting; Humans; Leg; Liver; Male; Muscle, Skeletal; Young Adult | 2016 |
Increased C3 Acylcarnitine Concentration in a Newborn.
Topics: Amino Acid Metabolism, Inborn Errors; Carnitine; Female; Humans; Hydroxocobalamin; Infant, Newborn; Mitochondrial Membrane Transport Proteins; Mutation; Neonatal Screening; Treatment Outcome | 2016 |
Plasma acylcarnitines during insulin stimulation in humans are reflective of age-related metabolic dysfunction.
Topics: Acetyl-CoA Carboxylase; Adult; Aged; Aged, 80 and over; Aging; Amino Acids; Carnitine; Female; Glucose; Glucose Clamp Technique; Humans; Insulin; Insulin Resistance; Male; Middle Aged; Muscle, Skeletal; Oxidation-Reduction; Phosphorylation; Young Adult | 2016 |
Plasma acylcarnitine profiling indicates increased fatty acid oxidation relative to tricarboxylic acid cycle capacity in young, healthy low birth weight men.
Topics: Adult; Birth Weight; Carnitine; Citric Acid Cycle; Cross-Over Studies; Denmark; Diabetes Mellitus, Type 2; Diet, High-Fat; Dietary Fats; Energy Intake; Fasting; Fatty Acids; Humans; Infant, Low Birth Weight; Insulin; Insulin Resistance; Lipid Metabolism; Male; Mitochondria; Oxidation-Reduction; Randomized Controlled Trials as Topic | 2016 |
Oleate dose-dependently regulates palmitate metabolism and insulin signaling in C2C12 myotubes.
Topics: Animals; Carnitine; Cell Line; Ceramides; Diglycerides; Fatty Acids; Insulin; Insulin Resistance; Mice; Muscle Fibers, Skeletal; Muscle, Skeletal; NF-kappa B; Oleic Acid; Oxidation-Reduction; p38 Mitogen-Activated Protein Kinases; Palmitates; Phosphorylation; Proto-Oncogene Proteins c-akt; Signal Transduction; Triglycerides | 2016 |
Acylcarnitines as markers of exercise-associated fuel partitioning, xenometabolism, and potential signals to muscle afferent neurons.
Topics: Adenosine Triphosphate; Adult; Amino Acids, Branched-Chain; Biomarkers; Carnitine; Citric Acid Cycle; Diabetes Mellitus, Type 2; Exercise; Fatty Acids; Female; Humans; Insulin Resistance; Middle Aged; Mitochondria, Muscle; Muscle, Skeletal; Neurons, Afferent; Obesity; Oxidation-Reduction; Oxidative Phosphorylation; Oxygen Consumption; Weight Loss | 2017 |
[An analysis of clinical characteristics and gene mutation in two patients with medium- and short-chain acyl-CoA dehydrogenase deficiency].
Topics: Acyl-CoA Dehydrogenase; Carnitine; Female; Humans; Infant; Infant, Newborn; Lipid Metabolism, Inborn Errors; Male; Mutation; Urea | 2016 |
Metabolite and Lipid Profiling of Biobank Plasma Samples Collected Prior to Onset of Rheumatoid Arthritis.
Topics: Adult; Area Under Curve; Arthritis, Rheumatoid; Biological Specimen Banks; Biomarkers; Body Mass Index; Carnitine; Chromatography, High Pressure Liquid; Discriminant Analysis; Fatty Acids; Female; Humans; Least-Squares Analysis; Lipids; Lysophosphatidylcholines; Metabolomics; Middle Aged; Principal Component Analysis; ROC Curve; Tryptophan | 2016 |
Novel Molecular Interactions of Acylcarnitines and Fatty Acids with Myoglobin.
Topics: Animals; Carnitine; Fatty Acids; Horses; Models, Chemical; Myoglobin | 2016 |
Cardiovascular Risk Factors Associated With Blood Metabolite Concentrations and Their Alterations During a 4-Year Period in a Population-Based Cohort.
Topics: Aged; Aged, 80 and over; Alcohol Drinking; Amino Acids; Biomarkers; Body Mass Index; Cardiovascular Diseases; Carnitine; Cross-Sectional Studies; Female; Germany; Hexoses; Humans; Linear Models; Lipids; Longitudinal Studies; Male; Metabolomics; Middle Aged; Multivariate Analysis; Obesity; Risk Assessment; Risk Factors; Sex Factors; Smoking; Time Factors | 2016 |
Acylcarnitine Profiles Reflect Metabolic Vulnerability for Necrotizing Enterocolitis in Newborns Born Premature.
Topics: Biomarkers; California; Carnitine; Cohort Studies; Confidence Intervals; Enterocolitis, Necrotizing; Female; Follow-Up Studies; Gestational Age; Humans; Incidence; Infant, Newborn; Infant, Premature; Intensive Care Units, Neonatal; Male; Multivariate Analysis; Neonatal Screening; Odds Ratio; Reproducibility of Results; Retrospective Studies; Risk Assessment; Vulnerable Populations | 2017 |
Analysis of amino acids and acyl carnitine profiles in low birth weight, preterm, and small for gestational age neonates.
Topics: Amino Acids; Carnitine; Dried Blood Spot Testing; Female; Gestational Age; Humans; Infant, Low Birth Weight; Infant, Newborn; Infant, Premature; Infant, Small for Gestational Age; Male; Metabolome; Retrospective Studies | 2017 |
Living on the edge: substrate competition explains loss of robustness in mitochondrial fatty-acid oxidation disorders.
Topics: Acyl-CoA Dehydrogenase; Animals; Carnitine; Computational Biology; Computer Simulation; Disease Models, Animal; Fatty Acids; Humans; Lipid Metabolism; Lipid Metabolism, Inborn Errors; Male; Metabolic Networks and Pathways; Mice; Mice, Inbred C57BL; Mice, Knockout; Mitochondria; Oxidation-Reduction; Proteomics; Substrate Specificity | 2016 |
Study of Carnitine/Acylcarnitine and Amino Acid Profile in Children and Adults With Acute Liver Failure.
Topics: Adolescent; Adult; Amino Acids; Biomarkers; Carnitine; Carnitine O-Palmitoyltransferase; Child; Child, Preschool; Female; Follow-Up Studies; Humans; Hypoglycemia; Infant; Lipid Metabolism, Inborn Errors; Liver Failure, Acute; Liver Transplantation; Male; Patient Acuity; Prospective Studies | 2017 |
Change of the metabolomic profile during short-term mononuclear cell storage.
Topics: Amines; Amino Acids; Apoptosis; Blood Preservation; Carnitine; CD4-Positive T-Lymphocytes; Chromatography, High Pressure Liquid; Glucose; Humans; Leukapheresis; Leukocytes, Mononuclear; Metabolomics; Phospholipids; Sphingolipids; Tandem Mass Spectrometry; Time Factors | 2017 |
A 61-Year-Old Woman with Muscle Fatigue and Increased Cardiac Troponin.
Topics: Carnitine; Creatine Kinase; Female; Humans; Lipid Metabolism, Inborn Errors; Middle Aged; Multiple Acyl Coenzyme A Dehydrogenase Deficiency; Muscle Fatigue; Muscle, Skeletal; Muscular Dystrophies; Necrosis; Troponin I; Troponin T | 2017 |
Profiles of Amino Acids and Acylcarnitines Related with Insecticide Exposure in Culex quinquefasciatus (Say).
Topics: Amino Acids; Animals; Carnitine; Culex; Insecticides; Larva; Metabolome; Tandem Mass Spectrometry | 2017 |
Mitochondrial trifunctional protein deficiency: an adult patient with similar progress to Charcot-Marie-Tooth disease.
Topics: Biomarkers; Cardiomyopathies; Carnitine; Charcot-Marie-Tooth Disease; Diagnosis, Differential; Disease Progression; Genetic Testing; Humans; Lipid Metabolism, Inborn Errors; Male; Middle Aged; Mitochondrial Myopathies; Mitochondrial Trifunctional Protein; Mitochondrial Trifunctional Protein, beta Subunit; Mutation; Nervous System Diseases; Peripheral Nervous System Diseases; Recurrence; Rhabdomyolysis | 2017 |
Serum Acylcarnitines and Risk of Cardiovascular Death and Acute Myocardial Infarction in Patients With Stable Angina Pectoris.
Topics: Aged; Angina Pectoris; Biomarkers; Carnitine; Cause of Death; Follow-Up Studies; Heart Arrest; Humans; Middle Aged; Myocardial Infarction; Norway; Prognosis; Prospective Studies; Risk Assessment; Risk Factors; Survival Rate | 2017 |
Specific circulating phospholipids, acylcarnitines, amino acids and biogenic amines are aerobic exercise markers.
Topics: Amino Acids; Biogenic Amines; Biomarkers; Carnitine; Chromatography, Liquid; Cross-Sectional Studies; Exercise; Humans; Male; Middle Aged; Phospholipids; Tandem Mass Spectrometry | 2017 |
Impact of a cafeteria diet and daily physical training on the rat serum metabolome.
Topics: Animals; Bile Acids and Salts; C-Reactive Protein; Carnitine; Chromatography, Liquid; Diet; Fatty Acids, Unsaturated; Female; Glycerophospholipids; Leptin; Metabolome; Metabolomics; Physical Conditioning, Animal; Rats, Sprague-Dawley; Tandem Mass Spectrometry; Time Factors; Vitamin A; Vitamin E | 2017 |
Decrease in Long-Chain Acylcarnitine Tissue Content Determines the Duration of and Correlates with the Cardioprotective Effect of Methyl-GBB.
Topics: Animals; Betaine; Biotransformation; Cardiotonic Agents; Carnitine; Down-Regulation; gamma-Aminobutyric Acid; Half-Life; Heart; Male; Membrane Transport Modulators; Molecular Weight; Myocardial Infarction; Myocardium; Perfusion; Quaternary Ammonium Compounds; Random Allocation; Rats, Wistar; Solute Carrier Family 22 Member 5; Time Factors; Tissue Distribution | 2017 |
Endometriosis is associated with aberrant metabolite profiles in plasma.
Topics: Adult; Area Under Curve; Belgium; Biomarkers; Carnitine; Case-Control Studies; Chromatography, High Pressure Liquid; Endometriosis; Female; Hospitals, University; Humans; Laparoscopy; Lipids; Metabolomics; Pilot Projects; Predictive Value of Tests; ROC Curve; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry | 2017 |
Matrix effect-corrected liquid chromatography/tandem mass-spectrometric method for determining acylcarnitines in human urine.
Topics: Adult; Calibration; Carnitine; Child; Chromatography, Liquid; Humans; Reproducibility of Results; Tandem Mass Spectrometry; Urinalysis | 2017 |
Microbiome and metabolome modifying effects of several cardiovascular disease interventions in apo-E
Topics: Acetates; Animals; Apolipoproteins E; Atherosclerosis; Atorvastatin; beta-Glucans; Butyrates; Cardiovascular Diseases; Carnitine; Cholesterol; Cholesterol, Dietary; Diet, High-Fat; Dietary Supplements; Feces; Gastrointestinal Microbiome; Hemiterpenes; Limosilactobacillus reuteri; Male; Metabolome; Mice; Obesity; Pentanoic Acids; Probiotics | 2017 |
Rapid differentiating colorectal cancer and colorectal polyp using dried blood spot mass spectrometry metabolomic approach.
Topics: Adult; Aged; Aged, 80 and over; Amino Acids; Carnitine; Colonic Polyps; Colorectal Neoplasms; Dried Blood Spot Testing; Female; Humans; Male; Metabolomics; Middle Aged; Reproducibility of Results | 2017 |
Systems characterization of differential plasma metabolome perturbations following thrombotic and non-thrombotic myocardial infarction.
Topics: Adult; Aged; Blood; Carnitine; Coronary Thrombosis; Female; Gas Chromatography-Mass Spectrometry; Glucocorticoids; Humans; Hypoxia; Male; Metabolome; Metabolomics; Middle Aged; Monoglycerides; Myocardial Infarction; Oxygen Consumption; Pregnenolone; Tandem Mass Spectrometry | 2017 |
Increased urine acylcarnitines in diabetic ApoE-/- mice: Hydroxytetradecadienoylcarnitine (C14:2-OH) reflects diabetic nephropathy in a context of hyperlipidemia.
Topics: Animals; Apolipoproteins E; Biomarkers; Carnitine; Diabetic Nephropathies; Hyperlipidemias; Male; Mice; Mice, Knockout; Up-Regulation | 2017 |
Amino acid and acylcarnitine profiles in perinatal asphyxia: a case-control study.
Topics: Amino Acids; Asphyxia Neonatorum; Carnitine; Case-Control Studies; Chromatography, Liquid; Female; Humans; Hypoxia-Ischemia, Brain; Infant, Newborn; Male; Mass Spectrometry; Metabolome | 2018 |
Dynamics of L-Carnitine in Plasma and Urine in Patients Undergoing Cisplatin Chemotherapy.
Topics: Antineoplastic Agents; Body Mass Index; Carnitine; Cisplatin; Female; Glomerular Filtration Rate; Humans; Male; Middle Aged; Muscle, Skeletal; Neoplasms | 2017 |
Nitric oxide inhibits the mitochondrial carnitine/acylcarnitine carrier through reversible S-nitrosylation of cysteine 136.
Topics: Amino Acid Sequence; Animals; Biological Transport; Carnitine; Carnitine Acyltransferases; Conserved Sequence; Cysteine; Dithioerythritol; Liposomes; Mitochondria; Models, Molecular; Nitric Oxide; Nitric Oxide Donors; Nitrogen; Oxidation-Reduction; Protein Conformation; Protein Processing, Post-Translational; Rats; S-Nitrosoglutathione; Sequence Alignment; Sequence Homology, Amino Acid | 2017 |
Changes in Hepatic TRβ Protein Expression, Lipogenic Gene Expression, and Long-Chain Acylcarnitine Levels During Chronic Hyperthyroidism and Triiodothyronine Withdrawal in a Mouse Model.
Topics: Adipogenesis; Animals; Body Weight; Carnitine; Chronic Disease; Disease Models, Animal; Gene Expression Regulation; Hyperthyroidism; Lipogenesis; Liver; Male; Metabolomics; Mice; Mice, Inbred C57BL; Mice, Knockout; Thyroid Hormone Receptors beta; Thyroid Hormones; Time Factors; Triiodothyronine | 2017 |
Metabolomic profiling of ascending thoracic aortic aneurysms and dissections - Implications for pathophysiology and biomarker discovery.
Topics: Adult; Aged; Amino Acids; Aorta, Thoracic; Aortic Aneurysm, Thoracic; Aortic Dissection; Biomarkers; Carnitine; Case-Control Studies; Ceramides; Female; Hexoses; Humans; Lysophosphatidylcholines; Male; Metabolomics; Middle Aged; Phosphatidylcholines; Sphingomyelins; Young Adult | 2017 |
Developmental regulation and localization of carnitine palmitoyltransferases (CPTs) in rat brain.
Topics: Acyl Coenzyme A; Animals; Brain; Carnitine; Carnitine O-Palmitoyltransferase; Fatty Acids; Liver; Male; Mitochondria; Oleic Acid; Rats, Sprague-Dawley | 2017 |
Sustained NFκB inhibition improves insulin sensitivity but is detrimental to muscle health.
Topics: Aging; Animals; Blood Glucose; Carnitine; Cell Line; Ceramides; Female; Gene Expression Regulation; Humans; Insulin Resistance; Male; Mice; Mice, Inbred C57BL; Muscle, Skeletal; Muscular Atrophy; Myoblasts; Myostatin; NF-kappa B; NF-KappaB Inhibitor alpha; Sarcopenia | 2017 |
Identification and diagnostic value of phytanoyl- and pristanoyl-carnitine in plasma from patients with peroxisomal disorders.
Topics: Carnitine; Cells, Cultured; Diterpenes; Fatty Acids; Humans; Oxidation-Reduction; Peroxisomal Disorders; Phytanic Acid; Refsum Disease | 2017 |
Development of a Data-Independent Targeted Metabolomics Method for Relative Quantification Using Liquid Chromatography Coupled with Tandem Mass Spectrometry.
Topics: Biomarkers; Carnitine; Chromatography, Liquid; Humans; Male; Metabolome; Metabolomics; Middle Aged; Tandem Mass Spectrometry | 2017 |
N-acyl Taurines and Acylcarnitines Cause an Imbalance in Insulin Synthesis and Secretion Provoking β Cell Dysfunction in Type 2 Diabetes.
Topics: Animals; Carnitine; Diabetes Mellitus, Type 2; Humans; Insulin; Insulin Secretion; Insulin-Secreting Cells; Mice; Taurine | 2017 |
[Fat emulsion tolerance in preterm infants of different gestational ages in the early stage after birth].
Topics: Carnitine; Fat Emulsions, Intravenous; Gestational Age; Humans; Infant, Newborn; Infant, Premature | 2017 |
Association between resistance to erythropoiesis-stimulating agents and carnitine profile in patients on maintenance haemodialysis.
Topics: Adult; Aged; Anemia; Biomarkers; Carnitine; Chromatography, Liquid; Cross-Sectional Studies; Drug Resistance; Female; Hematinics; Humans; Kidney Failure, Chronic; Male; Middle Aged; Renal Dialysis; Retrospective Studies; Risk Factors; Tandem Mass Spectrometry; Treatment Outcome | 2018 |
Targeted Metabolomics Demonstrates Distinct and Overlapping Maternal Metabolites Associated With BMI, Glucose, and Insulin Sensitivity During Pregnancy Across Four Ancestry Groups.
Topics: Amino Acids; Blood Glucose; Body Mass Index; Carnitine; Cohort Studies; Female; Gestational Age; Glucose Tolerance Test; Humans; Hyperglycemia; Insulin Resistance; Metabolomics; Pregnancy; Pregnancy Complications; Pregnancy Outcome; Racial Groups | 2017 |
Early Postnatal Diets Affect the Bioregional Small Intestine Microbiome and Ileal Metabolome in Neonatal Pigs.
Topics: Aminoisobutyric Acids; Animals; Animals, Newborn; Bacteria; Carnitine; Diet; Duodenum; Feeding Behavior; Female; Food, Formulated; Gastrointestinal Microbiome; Humans; Ileum; Intestine, Small; Male; Metabolome; Milk Proteins; Soybean Proteins; Swine | 2017 |
The metabolic analysis of psoriasis identifies the associated metabolites while providing computational models for the monitoring of the disease.
Topics: Adult; Aged; Alkanes; Amino Acids; Carnitine; Computer Simulation; Dicarboxylic Acids; Female; Humans; Male; Metabolome; Middle Aged; Phosphatidylcholines; Phytol; Psoriasis; Urea; Young Adult | 2017 |
DGAT1-Dependent Lipid Droplet Biogenesis Protects Mitochondrial Function during Starvation-Induced Autophagy.
Topics: Amino Acids; Animals; Autophagy; Carnitine; Diacylglycerol O-Acyltransferase; Humans; Isotope Labeling; Lipid Droplets; Mechanistic Target of Rapamycin Complex 1; Mice; Mitochondria; Models, Biological; Multiprotein Complexes; Palmitic Acid; TOR Serine-Threonine Kinases; Triglycerides | 2017 |
Selective and accurate C5 acylcarnitine quantitation by UHPLC-MS/MS: Distinguishing true isovaleric acidemia from pivalate derived interference.
Topics: Amino Acid Metabolism, Inborn Errors; Carnitine; Chromatography, High Pressure Liquid; Humans; Isovaleryl-CoA Dehydrogenase; Limit of Detection; Reproducibility of Results; Tandem Mass Spectrometry | 2017 |
Blood Metabolic Signatures of Body Mass Index: A Targeted Metabolomics Study in the EPIC Cohort.
Topics: Adult; Amino Acids; Bile Duct Neoplasms; Biogenic Amines; Blood Proteins; Body Mass Index; Carcinoma; Carnitine; Case-Control Studies; Diabetes Mellitus; Europe; Gene Expression; Hexoses; Humans; Linear Models; Liver Neoplasms; Longitudinal Studies; Male; Metabolome; Middle Aged; Nutrition Assessment; Obesity; Phosphatidylcholines; Risk Factors; Sphingomyelins | 2017 |
Acute and long-term administration of palmitoylcarnitine induces muscle-specific insulin resistance in mice.
Topics: Animals; Blood Glucose; Carbohydrate Metabolism; Carnitine; Dietary Fats; Energy Metabolism; Glucose; Humans; Insulin; Insulin Resistance; Lipid Metabolism; Mice; Muscle, Skeletal; Palmitoylcarnitine | 2017 |
Decreased long-chain acylcarnitines from insufficient β-oxidation as potential early diagnostic markers for Parkinson's disease.
Topics: Aged; Biomarkers; Carnitine; Cohort Studies; Fatty Acids; Female; Humans; Male; Metabolome; Metabolomics; Middle Aged; Mitochondria; Models, Biological; Muscle, Skeletal; Oxidation-Reduction; Parkinson Disease; ROC Curve; Severity of Illness Index | 2017 |
Profiling of Acylcarnitines in First Episode Psychosis before and after Antipsychotic Treatment.
Topics: Adolescent; Adult; Antipsychotic Agents; Biomarkers; Body Mass Index; Carnitine; Chromatography, Liquid; Female; Humans; Insulin Resistance; Interleukin-2; Interleukin-6; Male; Metabolomics; Middle Aged; Psychotic Disorders; Tandem Mass Spectrometry; Young Adult | 2017 |
Acylcarnitines profile best predicts survival in horses with atypical myopathy.
Topics: Animals; Carnitine; Horse Diseases; Horses; Muscular Diseases; Prognosis; Survival Rate | 2017 |
Comprehensive Analysis of Acylcarnitine Species in db/db Mouse Using a Novel Method of High-Resolution Parallel Reaction Monitoring Reveals Widespread Metabolic Dysfunction Induced by Diabetes.
Topics: Animals; Carnitine; Chromatography, High Pressure Liquid; Diabetes Mellitus, Experimental; Limit of Detection; Male; Mice; Mice, Inbred C57BL; Principal Component Analysis; Tandem Mass Spectrometry | 2017 |
The Liver as a Hub in Thermogenesis.
Topics: Adipose Tissue, Brown; Animals; Carnitine; Energy Metabolism; Lipids; Liver; Mice; Thermogenesis | 2017 |
Global Analysis of Plasma Lipids Identifies Liver-Derived Acylcarnitines as a Fuel Source for Brown Fat Thermogenesis.
Topics: Adipose Tissue, Brown; Aging; Animals; Body Temperature; Carnitine; Carnitine O-Palmitoyltransferase; Citric Acid Cycle; Cold Temperature; Fatty Acids; Gene Expression Regulation; Gene Knockdown Techniques; Hepatocyte Nuclear Factor 4; Lipids; Lipolysis; Liver; Mice; Phenotype; Thermogenesis; Time Factors | 2017 |
Lower mitochondrial DNA and altered mitochondrial fuel metabolism in HIV-exposed uninfected infants in Cameroon.
Topics: Amino Acids, Branched-Chain; Anti-Retroviral Agents; Cameroon; Carnitine; DNA, Mitochondrial; Energy Metabolism; HIV Infections; Humans; Infant; Mitochondria; Nevirapine; Real-Time Polymerase Chain Reaction; Tandem Mass Spectrometry; Zidovudine | 2017 |
Fine Mapping and Functional Analysis Reveal a Role of SLC22A1 in Acylcarnitine Transport.
Topics: Alleles; Alternative Splicing; Animals; Biological Transport; Carnitine; Cells, Cultured; Cohort Studies; CRISPR-Cas Systems; Female; Gene Expression Regulation; Genome-Wide Association Study; High-Throughput Nucleotide Sequencing; Humans; Liver; Male; Metabolic Diseases; Metabolomics; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Knockout; Organic Cation Transporter 1; Polymorphism, Single Nucleotide; Tissue Distribution | 2017 |
Metabolomic profile of arterial stiffness in aged adults.
Topics: Age Factors; Aged; Aged, 80 and over; Aging; Amino Acids; Arterial Pressure; Biomarkers; Cardiovascular Diseases; Carnitine; Chromatography, High Pressure Liquid; Female; Gas Chromatography-Mass Spectrometry; Humans; Male; Manometry; Metabolomics; Middle Aged; Predictive Value of Tests; Prospective Studies; Pulse Wave Analysis; Risk Factors; Vascular Stiffness | 2018 |
Effects of birth weight on profiles of dried blood amino-acids and acylcarnitines.
Topics: Amino Acids; Birth Weight; Carnitine; False Positive Reactions; Humans; Infant, Newborn; Neonatal Screening | 2018 |
Maternal obesity and increased neonatal adiposity correspond with altered infant mesenchymal stem cell metabolism.
Topics: Adiposity; Amino Acids; Biomarkers; Carnitine; Colorado; Electron Transport; Energy Metabolism; Fatty Acids; Female; Gene Expression Regulation, Developmental; Humans; Infant; Infant, Newborn; Insulin; Lipid Metabolism; Lipids; Longitudinal Studies; Male; Maternal Nutritional Physiological Phenomena; Mesenchymal Stem Cells; Mitochondria; Mitochondrial Diseases; Muscle Cells; Obesity; Pregnancy | 2017 |
Short communication: Circulating fatty acylcarnitines are elevated in overweight periparturient dairy cows in association with sphingolipid biomarkers of insulin resistance.
Topics: Animals; Biomarkers; Carnitine; Cattle; Cattle Diseases; Ceramides; Fatty Acids; Female; Insulin Resistance; Lactation; Lipid Metabolism; Overweight; Peripartum Period; Pregnancy; Sphingolipids | 2018 |
[Rhabdomyolysis - may it be a metabolic myopathy? Case report and diagnostic algorithm].
Topics: Algorithms; Carnitine; Diagnosis, Differential; Female; Humans; Middle Aged; Muscular Diseases; Rhabdomyolysis | 2017 |
Similarities between acylcarnitine profiles in large for gestational age newborns and obesity.
Topics: Cardiomyopathies; Carnitine; Female; Gestational Age; Humans; Hyperammonemia; Infant, Newborn; Infant, Small for Gestational Age; Male; Muscular Diseases; Obesity; Pregnancy | 2017 |
Serum metabolites and risk of myocardial infarction and ischemic stroke: a targeted metabolomic approach in two German prospective cohorts.
Topics: Aged; Amino Acids; Biomarkers; Brain Ischemia; Carnitine; Female; Germany; Humans; Incidence; Male; Metabolomics; Middle Aged; Myocardial Infarction; Phosphatidylcholines; Prospective Studies; Risk Factors; Serum; Stroke; Triglycerides | 2018 |
Reference values of amino acids, acylcarnitines and succinylacetone by tandem mass spectrometry for use in newborn screening in southwest Colombia.
Topics: Amino Acids; Biomarkers; Carnitine; Colombia; Cross-Sectional Studies; False Positive Reactions; Heptanoates; Humans; Infant, Newborn; Metabolism, Inborn Errors; Reference Values; Sensitivity and Specificity; Tandem Mass Spectrometry | 2017 |
Plasma acylcarnitine concentrations reflect the acylcarnitine profile in cardiac tissues.
Topics: Animals; Blood Glucose; Carnitine; Glucose Tolerance Test; Insulin; Liver; Male; Metabolic Diseases; Mice; Muscle, Skeletal; Myocardium; Random Allocation; Rats, Wistar; Running | 2017 |
Propofol Related Infusion Syndrome: Ultrastructural Evidence for a Mitochondrial Disorder.
Topics: Carnitine; Craniotomy; Hematoma, Subdural, Intracranial; Humans; Infusions, Intravenous; Male; Microscopy, Electron; Mitochondria, Heart; Mitochondria, Liver; Mitochondria, Muscle; Mitochondrial Diseases; Postoperative Complications; Propofol Infusion Syndrome; Young Adult | 2018 |
Mice with an Oncogenic HRAS Mutation are Resistant to High-Fat Diet-Induced Obesity and Exhibit Impaired Hepatic Energy Homeostasis.
Topics: Animals; Carnitine; Diet, High-Fat; Energy Metabolism; Face; Fatty Acids; Female; Gene Expression Regulation; Gene Knock-In Techniques; Glucose; Glutamine; Homeostasis; Hypertrophy; Kidney; Liver; Mice; Mitochondria; Mutation; Myocytes, Cardiac; Obesity; Oncogenes; Oxidation-Reduction; Phenotype; Proto-Oncogene Proteins p21(ras); ras Proteins; Weight Gain | 2018 |
Non-invasive test using palmitate in patients with suspected fatty acid oxidation defects: disease-specific acylcarnitine patterns can help to establish the diagnosis.
Topics: Acyl-CoA Dehydrogenase; Adolescent; Analysis of Variance; Carnitine; Child; Child, Preschool; Fatty Acids; Female; Humans; Infant; Infant, Newborn; Lipid Metabolism, Inborn Errors; Male; Neonatal Screening; Palmitates; Reproducibility of Results; Tandem Mass Spectrometry | 2017 |
Metabolomic analysis of 92 pulmonary embolism patients from a nested case-control study identifies metabolites associated with adverse clinical outcomes.
Topics: Adolescent; Adult; Aged; Carnitine; Case-Control Studies; Fatty Acids; Female; Hemoglobins; Humans; Hypoxanthine; Inosine; Male; Metabolome; Middle Aged; Porphyrins; Prospective Studies; Pulmonary Embolism; Purines; Risk Assessment; Treatment Outcome; Tricarboxylic Acids; Young Adult | 2018 |
Association of Acylcarnitines With Left Ventricular Remodeling in Patients With Severe Aortic Stenosis Undergoing Transcatheter Aortic Valve Replacement.
Topics: Aged, 80 and over; Aortic Valve Stenosis; Biomarkers; Carnitine; Choline; Diabetes Complications; Female; Humans; Hypertension; Kynurenine; Male; Renal Insufficiency, Chronic; Stroke Volume; Transcatheter Aortic Valve Replacement; Ventricular Remodeling | 2018 |
A quantitative multimodal metabolomic assay for colorectal cancer.
Topics: Adenoma; Aged; Amino Acids; Biomarkers, Tumor; Carnitine; Colorectal Neoplasms; Early Detection of Cancer; Female; Humans; Male; Mass Spectrometry; Metabolome; Metabolomics; Middle Aged; Phosphatidylcholines; Sphingomyelins | 2018 |
Biochemical signatures mimicking multiple carboxylase deficiency in children with mutations in MT-ATP6.
Topics: Adolescent; Carnitine; Child; Child, Preschool; Cohort Studies; Female; Genetic Testing; Humans; Infant; Infant, Newborn; Male; Mitochondrial Proton-Translocating ATPases; Multiple Carboxylase Deficiency; Mutation; Retrospective Studies; Young Adult | 2019 |
Medium- and long-chain acylcarnitines are associated with osteoarthritis severity and arterial stiffness in end-stage osteoarthritis patients: a case-control study.
Topics: Aged; Biomarkers; Carnitine; Case-Control Studies; Down-Regulation; Female; Humans; Male; Metabolomics; Middle Aged; Osteoarthritis, Hip; Osteoarthritis, Knee; Principal Component Analysis; Prospective Studies; Pulse Wave Analysis; Severity of Illness Index; Vascular Stiffness | 2018 |
Medium-chain acyl-CoA dehydrogenase deficiency: Two novel ACADM mutations identified in a retrospective screening.
Topics: Acyl-CoA Dehydrogenase; Carboxylic Acids; Carnitine; Dried Blood Spot Testing; Female; Humans; Infant; Infant, Newborn; Lipid Metabolism, Inborn Errors; Male; Mutation; Neonatal Screening; Retrospective Studies | 2018 |
Lysosomal acid lipase regulates fatty acid channeling in brown adipose tissue to maintain thermogenesis.
Topics: Acetyl Coenzyme A; Adipocytes, Brown; Adipose Tissue, Brown; Animals; Autophagy; Body Temperature; Carnitine; Cold Temperature; Disease Progression; Dyslipidemias; Energy Metabolism; Fatty Acids; Glucose; Hypothermia, Induced; Lipid Droplets; Lipolysis; Male; Mice, Inbred C57BL; Muscles; Oxidation-Reduction; Oxygen Consumption; Sterol Esterase; Thermogenesis; Uncoupling Protein 1 | 2018 |
Septic Shock Nonsurvivors Have Persistently Elevated Acylcarnitines Following Carnitine Supplementation.
Topics: Aged; Carnitine; Fatty Acids; Female; Humans; Insulin; Magnetic Resonance Spectroscopy; Male; Middle Aged; Shock, Septic | 2018 |
Lipidomic analysis of serum samples from migraine patients.
Topics: Adult; Biomarkers; Carnitine; Ceramides; Chromatography, Liquid; Female; Humans; Lipids; Lysophosphatidylcholines; Lysophospholipids; Male; Mass Spectrometry; Migraine Disorders | 2018 |
Metabolomics signatures associated with an oral glucose challenge in pregnant women.
Topics: Adolescent; Adult; Bile Acids and Salts; Blood Glucose; Carnitine; Diabetes, Gestational; Diglycerides; Fatty Acids; Female; Glucose; Glucose Tolerance Test; Humans; Lipid Metabolism; Metabolomics; Pregnancy; Young Adult | 2019 |
Cord Blood Metabolic Signatures of Birth Weight: A Population-Based Study.
Topics: Birth Weight; Carnitine; Chromatography, High Pressure Liquid; Cohort Studies; Docosahexaenoic Acids; Environmental Exposure; Europe; Female; Fetal Blood; Fetal Development; Fetus; Humans; Indoles; Infant, Newborn; Male; Mass Spectrometry; Metabolome; Particulate Matter; Phosphatidylcholines; Pregnancy; Progesterone; Prostaglandins; Reference Standards; Tryptophan; Vitamin A | 2018 |
Kruppel-like factor 15 is required for the cardiac adaptive response to fasting.
Topics: Adaptation, Physiological; Animals; Carnitine; DNA-Binding Proteins; Echocardiography; Fasting; Heart; Kruppel-Like Transcription Factors; Lipid Metabolism; Male; Mice; Mice, Knockout; Mitochondria, Heart; Transcription Factors | 2018 |
Interventional Left Atrial Appendage Closure Affects the Metabolism of Acylcarnitines.
Topics: Aged; Aged, 80 and over; Atrial Appendage; Atrial Fibrillation; Biomarkers; Carnitine; Cohort Studies; Endovascular Procedures; Female; Humans; Male; Metabolomics; Prospective Studies; Regression Analysis; Stroke; Vascular Closure Devices | 2018 |
Insulin-resistance in glycogen storage disease type Ia: linking carbohydrates and mitochondria?
Topics: Acids; Adolescent; Adult; Antiporters; Biomarkers; Carnitine; Case-Control Studies; Child; Child, Preschool; Female; Glucose-6-Phosphatase; Glycogen Storage Disease Type I; Humans; Insulin; Insulin Resistance; Linear Models; Male; Mitochondrial Diseases; Monosaccharide Transport Proteins; Multivariate Analysis; Urinalysis; Young Adult | 2018 |
Elevated Medium-Chain Acylcarnitines Are Associated With Gestational Diabetes Mellitus and Early Progression to Type 2 Diabetes and Induce Pancreatic β-Cell Dysfunction.
Topics: Adult; Animals; Carnitine; Case-Control Studies; Cell Respiration; Diabetes Mellitus, Type 2; Diabetes, Gestational; Disease Progression; Female; Glucose Intolerance; Humans; Insulin; Insulin Secretion; Insulin-Secreting Cells; Islets of Langerhans; Mice; Postpartum Period; Pregnancy | 2018 |
CPT2 downregulation adapts HCC to lipid-rich environment and promotes carcinogenesis via acylcarnitine accumulation in obesity.
Topics: Adult; Aged; Animals; Carcinoma, Hepatocellular; Carnitine; Carnitine O-Palmitoyltransferase; Case-Control Studies; Disease Models, Animal; Female; Humans; Liver Neoplasms; Male; Mice; Middle Aged; Non-alcoholic Fatty Liver Disease; Obesity | 2018 |
A Plasma Metabolomic Signature of the Exfoliation Syndrome Involves Amino Acids, Acylcarnitines, and Polyamines.
Topics: Aged; Amino Acids; Biomarkers; Carnitine; Exfoliation Syndrome; Female; Glaucoma, Open-Angle; Humans; Male; Mass Spectrometry; Metabolome; Metabolomics; Polyamines | 2018 |
Obesity-Related Metabolomic Profiles and Discrimination of Metabolically Unhealthy Obesity.
Topics: Adolescent; Adult; Carnitine; Case-Control Studies; Humans; Iran; Lysophosphatidylcholines; Metabolomics; Middle Aged; Obesity; Phenotype; Risk Assessment; Young Adult | 2018 |
Arsenic induces cardiac rhythm dysfunction and acylcarnitines metabolism perturbation in rats.
Topics: Animals; Arsenites; Carnitine; Dose-Response Relationship, Drug; Electrocardiography; Environmental Pollutants; Heart Rate; Long QT Syndrome; Male; Rats, Sprague-Dawley; Sodium Compounds | 2018 |
Differential requirements for processing and transport of short-chain versus long-chain O-acylcarnitines in Pseudomonas aeruginosa.
Topics: ATP-Binding Cassette Transporters; Biological Transport, Active; Carnitine; Carrier Proteins; Extracellular Space; Hydrolases; Hydrolysis; Models, Biological; Mutation; Pseudomonas aeruginosa | 2018 |
Use of Metabolomics as a Complementary Omic Approach to Implement Risk Criteria for First-Degree Relatives of Gastric Cancer Patients.
Topics: Age Factors; Biomarkers, Tumor; Carnitine; Computational Biology; Early Detection of Cancer; Family; Female; Helicobacter Infections; Humans; Male; Metabolome; Metabolomics; Risk Assessment; ROC Curve; Sphingomyelins; Stomach Neoplasms | 2018 |
Adaptive remodeling of skeletal muscle energy metabolism in high-altitude hypoxia: Lessons from AltitudeOmics.
Topics: Acclimatization; Altitude; Altitude Sickness; Amino Acids; Carnitine; Energy Metabolism; Fatty Acids; Female; Glycolysis; Healthy Volunteers; Humans; Male; Metabolome; Mitochondria, Muscle; Muscle Proteins; Muscle, Skeletal; Oxidation-Reduction; Pentose Phosphate Pathway; Phosphorylation; Proteolysis; Proteomics; Purine Nucleotides; Random Allocation; Stress, Physiological; Young Adult | 2018 |
Targeted metabolomic profiling in rat tissues reveals sex differences.
Topics: Amino Acids; Animals; Carnitine; Cluster Analysis; Discriminant Analysis; Female; Kidney; Liver; Male; Metabolomics; Multivariate Analysis; Myocardium; Organ Specificity; Principal Component Analysis; Rats; Rats, Sprague-Dawley; Sex Characteristics | 2018 |
Phosphorylation of MCAD selectively rescues PINK1 deficiencies in behavior and metabolism.
Topics: Acyl-CoA Dehydrogenase; Adenosine Triphosphate; Amino Acid Sequence; Amino Acids; Animals; Animals, Genetically Modified; Carnitine; Drosophila melanogaster; Drosophila Proteins; Oxidation-Reduction; Phenotype; Phosphorylation; Phosphoserine; Protein Serine-Threonine Kinases | 2018 |
Orange juice affects acylcarnitine metabolism in healthy volunteers as revealed by a mass-spectrometry based metabolomics approach.
Topics: Adult; Carnitine; Chromatography, Liquid; Citrus sinensis; Female; Fruit and Vegetable Juices; Gas Chromatography-Mass Spectrometry; Humans; Male; Mass Spectrometry; Metabolomics; Middle Aged; Reference Values; Young Adult | 2018 |
Risk of gestational diabetes mellitus in relation to plasma concentrations of amino acids and acylcarnitines: A nested case-control study.
Topics: Adult; Amino Acids; Biomarkers; Carnitine; Case-Control Studies; Diabetes, Gestational; Female; Humans; Pregnancy | 2018 |
Carnitine Deficiency in Chinese Children with Epilepsy on Valproate Monotherapy.
Topics: Anticonvulsants; Beijing; Carnitine; Case-Control Studies; Child, Preschool; Deficiency Diseases; Epilepsy; Female; Humans; Infant; Male; Valproic Acid | 2018 |
Strategy for Comprehensive Identification of Acylcarnitines Based on Liquid Chromatography-High-Resolution Mass Spectrometry.
Topics: Adult; Animals; Carnitine; Chromatography, Liquid; Humans; Molecular Structure; Rats; Tandem Mass Spectrometry | 2018 |
PPARα Mediates the Hepatoprotective Effects of Nutmeg.
Topics: Animals; Carnitine; Chemical and Drug Induced Liver Injury; Lipids; Metabolomics; Mice; Mice, Knockout; Myristica; Oxidative Stress; PPAR alpha; Protective Agents; Thioacetamide | 2018 |
An unusually high frequency of SCAD deficiency caused by two pathogenic variants in the ACADS gene and its relationship to the ethnic structure in Slovakia.
Topics: Acyl-CoA Dehydrogenase; Butyryl-CoA Dehydrogenase; Carnitine; Ethnicity; Female; Gene Frequency; Genetic Testing; Humans; Infant, Newborn; Lipid Metabolism, Inborn Errors; Male; Mutation; Neonatal Screening; Polymorphism, Restriction Fragment Length; Sequence Analysis, DNA; Slovakia | 2018 |
Theacrine protects against nonalcoholic fatty liver disease by regulating acylcarnitine metabolism.
Topics: Animals; Apolipoproteins E; Carnitine; Diet, High-Fat; Energy Metabolism; Male; Mice; Mice, Knockout; Non-alcoholic Fatty Liver Disease; Oleic Acid; Plant Extracts; Protective Agents; Signal Transduction; Uric Acid | 2018 |
Mutations in PPCS, Encoding Phosphopantothenoylcysteine Synthetase, Cause Autosomal-Recessive Dilated Cardiomyopathy.
Topics: Amino Acid Sequence; Animals; Biosynthetic Pathways; Cardiomyopathy, Dilated; Carnitine; Child, Preschool; Coenzyme A; Demography; Drosophila; Enzyme Stability; Female; Fibroblasts; Genes, Recessive; Heart; High-Throughput Nucleotide Sequencing; Homozygote; Humans; Infant; Infant, Newborn; Magnetic Resonance Imaging; Male; Mutation; Pantetheine; Pedigree; Peptide Synthases; Reproducibility of Results; Saccharomyces cerevisiae | 2018 |
Atypical myopathy in Père David's deer (Elaphurus davidianus) associated with ingestion of hypoglycin A.
Topics: Acer; Animal Husbandry; Animals; Austria; Carnitine; Deer; Eating; Female; Germany; Hypoglycins; Male; Muscular Diseases; Seasons | 2018 |
Evaluation ofserum free carnitine/acylcarnitine levels and left ventricular systolic functions in children with idiopathic epilepsy receiving valproic acid.
Topics: Adolescent; Anticonvulsants; Biomarkers; Carnitine; Child; Child, Preschool; Electrocardiography; Epilepsy; Female; Humans; Male; Valproic Acid; Ventricular Function, Left | 2018 |
Remodeling of skeletal muscle mitochondrial proteome with high-fat diet involves greater changes to β-oxidation than electron transfer proteins in mice.
Topics: Adenosine Triphosphate; Animals; Carnitine; Cell Respiration; Chromatography, Liquid; Diet, Fat-Restricted; Diet, High-Fat; Electron Transport; Electron-Transferring Flavoproteins; Insulin Resistance; Lipid Metabolism; Male; Mass Spectrometry; Mice; Mice, Inbred C57BL; Mitochondria, Muscle; Mitochondrial Proteins; Muscle, Skeletal; Oxidation-Reduction; Oxygen Consumption; Protein Processing, Post-Translational; Proteome; Proteomics; Tandem Mass Spectrometry | 2018 |
An Exploratory Analysis of Potential New Biomarkers of Cognitive Function.
Topics: Aged; Amino Acids; Biomarkers; Carnitine; Cognitive Dysfunction; Cross-Sectional Studies; Female; Geriatric Assessment; Humans; Hydroxybutyrates; Longitudinal Studies; Male; Middle Aged; Neuropsychological Tests | 2019 |
Acylcarnitine Profiles in Plasma and Tissues of Hyperglycemic NZO Mice Correlate with Metabolite Changes of Human Diabetes.
Topics: Adipose Tissue; Animals; Blood Glucose; Carnitine; Fatty Acids, Nonesterified; Female; Hyperglycemia; Insulin; Kidney; Liver; Male; Mice; Mice, Obese; Muscle, Skeletal; Myocardium; Obesity; Triglycerides | 2018 |
Glucose challenge metabolomics implicates medium-chain acylcarnitines in insulin resistance.
Topics: 3T3-L1 Cells; Aged; Animals; Carnitine; Diabetes Mellitus, Type 2; Glucose; Glucose Tolerance Test; Humans; Insulin Resistance; Lipolysis; Male; Metabolomics; Mice | 2018 |
A pilot data analysis of a metabolomic HPLC-MS/MS study of patients with COPD.
Topics: Amino Acids; Carnitine; Case-Control Studies; Chromatography, High Pressure Liquid; Data Analysis; Humans; Pulmonary Disease, Chronic Obstructive; Tandem Mass Spectrometry | 2018 |
Acyl-carnitine, C5DC, and C26 as potential biomarkers for diagnosis of autism spectrum disorder in children.
Topics: Autism Spectrum Disorder; Biomarkers; Carnitine; Child; Child, Preschool; China; Female; Humans; Intelligence; Male; Neurodevelopmental Disorders | 2018 |
Persistent hypoglycemia associated with lipid storage myopathy in a paint foal.
Topics: Animals; Carnitine; Diagnosis, Differential; Fatal Outcome; Female; Horse Diseases; Horses; Hypoglycemia; Lipid Metabolism, Inborn Errors; Multiple Acyl Coenzyme A Dehydrogenase Deficiency; Muscular Dystrophies | 2018 |
Carnitine Precursors and Short-Chain Acylcarnitines in Water Buffalo Milk.
Topics: Animals; Buffaloes; Carnitine; Cattle; Female; Milk; Tandem Mass Spectrometry | 2018 |
Clinical Features of Multiple Acyl-CoA Dehydrogenase Deficiency With ETFDH Variants in the First Korean Cases.
Topics: Asian People; Base Sequence; Carnitine; Dietary Supplements; DNA Mutational Analysis; Electron-Transferring Flavoproteins; Gene Deletion; Humans; Infant, Newborn; Iron-Sulfur Proteins; Male; Multiple Acyl Coenzyme A Dehydrogenase Deficiency; Oxidoreductases Acting on CH-NH Group Donors; Pedigree; Republic of Korea; Riboflavin; Tandem Mass Spectrometry | 2018 |
Tissue acylcarnitine status in a mouse model of mitochondrial β-oxidation deficiency during metabolic decompensation due to influenza virus infection.
Topics: Acyl-CoA Dehydrogenase, Long-Chain; Animals; Cardiomyopathies; Carnitine; Congenital Bone Marrow Failure Syndromes; Disease Models, Animal; Fatty Acids; Female; Humans; Hypoglycemia; Lipid Metabolism, Inborn Errors; Lipid Peroxidation; Liver; Liver Failure; Metabolic Diseases; Mice; Mitochondrial Diseases; Muscle, Skeletal; Muscular Diseases; Myocardium; Oxidation-Reduction | 2018 |
The effect of high-fat diet and inhibition of ceramide production on insulin action in liver.
Topics: Animals; Biomarkers; Blood Glucose; Carnitine; Carnitine O-Palmitoyltransferase; Ceramides; Diet, High-Fat; Enzyme Inhibitors; Fatty Acids, Monounsaturated; Humans; Insulin; Insulin Resistance; Liver; Nerve Tissue Proteins; Rats, Wistar; Serine C-Palmitoyltransferase; Signal Transduction | 2019 |
Metabolite profiling of plasma in patients with ossification of the posterior longitudinal ligament.
Topics: Aged; Carnitine; Case-Control Studies; Cervical Vertebrae; Fatty Acids; Humans; Male; Metabolome; Middle Aged; Ossification of Posterior Longitudinal Ligament; Palmitoylcarnitine; Thiazolidines; Thyroxine | 2018 |
Alterations in plasma acylcarnitine and amino acid profiles may indicate poor nutrition during the suckling period due to maternal intake of an unbalanced diet and may predict later metabolic dysfunction.
Topics: Amino Acids; Animals; Animals, Suckling; Carnitine; Diet; Female; Lactation; Lipid Metabolism; Liver; Male; Maternal Nutritional Physiological Phenomena; Metabolic Diseases; Models, Animal; Multivariate Analysis; Nutritional Status; Pregnancy; Prenatal Exposure Delayed Effects; Rats | 2019 |
Dietary stearic acid regulates mitochondria in vivo in humans.
Topics: Adult; Beverages; Carnitine; Case-Control Studies; Cross-Over Studies; Diabetes Mellitus; Diet; Fatty Acids; Female; Humans; Male; Middle Aged; Mitochondria; Mitochondrial Dynamics; Musa; Oxygen; Stearic Acids | 2018 |
Selective Screening of Fatty Acids Oxidation Defects and Organic Acidemias by Liquid Chromatography/tandem Mass Spectrometry Acylcarnitine Analysis in Brazilian Patients.
Topics: Acyl-CoA Dehydrogenase; Amino Acid Metabolism, Inborn Errors; Brain Diseases, Metabolic; Brazil; Carnitine; Child, Preschool; Chromatography, Liquid; Fatty Acids; Female; Glutarates; Glutaryl-CoA Dehydrogenase; Humans; Infant, Newborn; Lipid Metabolism, Inborn Errors; Male; Mass Screening; Oxidation-Reduction; Prevalence; Tandem Mass Spectrometry; Young Adult | 2018 |
Clinical, Biochemical, and Genetic Findings of Cystinuria in Chinese Children.
Topics: Adolescent; Amino Acid Transport Systems, Basic; Amino Acid Transport Systems, Neutral; Amino Acids; Asian People; Carnitine; Child; Child, Preschool; China; Cystinuria; Family Health; Female; Humans; Infant; Infant, Newborn; Male; Mutation | 2018 |
Biochemical profile in an infant with neonatal hemochromatosis shows evidence of impairment of mitochondrial long-chain fatty acid oxidation.
Topics: Amino Acids; Carnitine; Cluster Analysis; Fatty Acids; Hemochromatosis; Humans; Infant; Lipid Peroxidation; Liver; Male; Mass Spectrometry; Mitochondria | 2019 |
Alterations in levels of intermediate-chained acylcarnitines associate with weight-gain following reestablishment of euthyroidism in Graves' disease.
Topics: Adult; Antithyroid Agents; Carnitine; Female; Graves Disease; Humans; Iodine Radioisotopes; Male; Middle Aged; Predictive Value of Tests; Weight Gain | 2019 |
Nonhuman Primates with Acute Radiation Syndrome: Results from a Global Serum Metabolomics Study after 7.2 Gy Total-Body Irradiation.
Topics: Acute Radiation Syndrome; Amino Acids; Animals; Carnitine; Cytokines; Humans; Lipids; Macaca mulatta; Mass Spectrometry; Metabolome; Metabolomics; Primates; Purines; Radiation, Ionizing; Whole-Body Irradiation | 2018 |
Dysregulated serum metabolites in staging of hepatocellular carcinoma.
Topics: Adult; Aged; Biomarkers, Tumor; Carcinoma, Hepatocellular; Carnitine; China; Cohort Studies; Docosahexaenoic Acids; Female; Humans; Linolenic Acids; Liver Neoplasms; Lymphatic Metastasis; Lysophosphatidylcholines; Male; Middle Aged; Neoplasm Grading; Neoplasm Staging; Principal Component Analysis; Prognosis; Proof of Concept Study; Sensitivity and Specificity; Up-Regulation; Young Adult | 2018 |
The saturation degree of fatty acids and their derived acylcarnitines determines the direct effect of metabolically active thyroid hormones on insulin sensitivity in skeletal muscle cells.
Topics: Animals; Biological Transport; Carnitine; Cell Line; Fatty Acids; Glycolysis; Insulin; Insulin Resistance; Mitochondria, Muscle; Muscle, Skeletal; Oxidation-Reduction; Rats; Signal Transduction; Thyroid Hormones | 2019 |
Cord Blood Metabolites Associated with Newborn Adiposity and Hyperinsulinemia.
Topics: Adiposity; Adult; Amino Acids; C-Peptide; Carnitine; Cross-Sectional Studies; Female; Fetal Blood; Humans; Hyperinsulinism; Infant, Newborn; Leptin; Male; Multivariate Analysis; Principal Component Analysis | 2018 |
Urinary and plasma metabolite differences detected by HPLC-ESI-QTOF-MS in systemic sclerosis patients.
Topics: Acylation; Adult; Aged; Arachidonic Acids; Biomarkers; Carnitine; Case-Control Studies; Chromatography, High Pressure Liquid; Endocannabinoids; Female; Glycerides; Glycine; Humans; Male; Metabolomics; Middle Aged; Predictive Value of Tests; Prognosis; Reproducibility of Results; Scleroderma, Systemic; Spectrometry, Mass, Electrospray Ionization; Urinalysis | 2019 |
Performance of LC/MS/MS in Analyzing Multiple Amino Acids and Acylcarnitines in Dried Blood Spot of Very Low Birth Weight, Low Birth Weight, and Normal Weight Neonates.
Topics: Amino Acids; Biomarkers; Birth Weight; Carnitine; Case-Control Studies; Chromatography, High Pressure Liquid; Dried Blood Spot Testing; Female; Humans; Infant Nutritional Physiological Phenomena; Infant, Newborn; Infant, Very Low Birth Weight; Male; Neonatal Screening; Nutritional Status; Predictive Value of Tests; Reproducibility of Results; Tandem Mass Spectrometry | 2018 |
A Non-Targeted LC-MS Profiling Reveals Elevated Levels of Carnitine Precursors and Trimethylated Compounds in the Cord Plasma of Pre-Eclamptic Infants.
Topics: Adult; Biomarkers; Carnitine; Case-Control Studies; Chromatography, Liquid; Creatine; Cross-Sectional Studies; Female; Fetal Blood; Humans; Infant, Newborn; Metabolomics; Phosphatidylcholines; Pre-Eclampsia; Pregnancy; Principal Component Analysis; Putrescine; Pyridoxic Acid; Tandem Mass Spectrometry; Tryptophan; Urea | 2018 |
Metabolomic profiles and development of metabolic risk during the pubertal transition: a prospective study in the ELEMENT Project.
Topics: Acetylcarnitine; Adolescent; Amino Acids, Branched-Chain; Aminoisobutyric Acids; Asparagine; Biomarkers; Blood Glucose; Body Composition; Body Mass Index; C-Peptide; Carnitine; Child; Cholesterol; Female; Humans; Hydroxyproline; Hyperglycemia; Insulin Resistance; Leptin; Male; Metabolome; Ornithine; Prospective Studies; Puberty; Regression Analysis; Risk Factors | 2019 |
Mitochondrial complex IV deficiency caused by a novel frameshift variant in MT-CO2 associated with myopathy and perturbed acylcarnitine profile.
Topics: Adolescent; Carnitine; Codon, Terminator; Electron Transport Complex IV; Female; Frameshift Mutation; Humans; Mitochondria, Muscle; Mitochondrial Diseases; Muscular Diseases | 2019 |
The Carnitine Shuttle Pathway is Altered in Patients With Neovascular Age-Related Macular Degeneration.
Topics: Aged; Carnitine; Choroidal Neovascularization; Chromatography, Liquid; Fatty Acids; Female; Humans; Male; Metabolic Networks and Pathways; Metabolomics; Tandem Mass Spectrometry; Wet Macular Degeneration | 2018 |
Acylcarnitine profiles in serum and muscle of dairy cows receiving conjugated linoleic acids or a control fat supplement during early lactation.
Topics: Animals; Carnitine; Cattle; Dietary Supplements; Fatty Acids; Female; Lactation; Linoleic Acids, Conjugated; Milk; Muscle, Skeletal; Parturition; Pregnancy | 2019 |
3D MALDI mass spectrometry imaging reveals specific localization of long-chain acylcarnitines within a 10-day time window of spinal cord injury.
Topics: Animals; Carnitine; Image Processing, Computer-Assisted; Imaging, Three-Dimensional; Macrophages; Male; Microglia; Rats; Rats, Wistar; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Spinal Cord Injuries | 2018 |
Plasma Acylcarnitines and Risk of Type 2 Diabetes in a Mediterranean Population at High Cardiovascular Risk.
Topics: Aged; Aged, 80 and over; Biomarkers; Cardiovascular Diseases; Carnitine; Case-Control Studies; Diabetes Mellitus, Type 2; Diet, Mediterranean; Female; Follow-Up Studies; Humans; Incidence; Male; Metabolomics; Middle Aged; Prognosis; Prospective Studies; Risk Factors; ROC Curve | 2019 |
Metabolomic Signature in Sera of Multiple Sclerosis Patients during Pregnancy.
Topics: Adult; Amino Acids; Biomarkers; Carnitine; Case-Control Studies; Female; Gonadal Steroid Hormones; Humans; Hydrocortisone; Metabolome; Multiple Sclerosis; Pregnancy; Pregnancy Complications; Sphingolipids | 2018 |
Plasma metabolites in first episode psychoses.
Topics: Adolescent; Adult; Biomarkers; Bipolar Disorder; Carnitine; Female; Humans; Lysophosphatidylcholines; Male; Phosphatidylcholines; Psychiatric Status Rating Scales; Psychotic Disorders; Schizophrenia; Young Adult | 2019 |
Yield of laboratory testing in pediatric ketogenic diet patients: Critical assessment of abnormal results and impact on clinical care.
Topics: Adolescent; Carnitine; Child; Child, Preschool; Clinical Laboratory Techniques; Cohort Studies; Critical Care Outcomes; Diet, Ketogenic; Epilepsy; Female; Humans; Infant; Male; Phosphorus | 2019 |
Effects of caloric restriction on neuropathic pain, peripheral nerve degeneration and inflammation in normometabolic and autophagy defective prediabetic Ambra1 mice.
Topics: Adaptor Proteins, Signal Transducing; Amino Acids; AMP-Activated Protein Kinases; Animals; Autophagy; Caloric Restriction; Carnitine; Cytokines; Energy Metabolism; Glucose; Heterozygote; Inflammation; Insulin Resistance; Male; Mice; Mice, Transgenic; Nerve Degeneration; Neuralgia; Prediabetic State; Schwann Cells | 2018 |
Peroxisomes can oxidize medium- and long-chain fatty acids through a pathway involving ABCD3 and HSD17B4.
Topics: Animals; ATP-Binding Cassette Transporters; Carnitine; Carnitine O-Palmitoyltransferase; CRISPR-Cas Systems; Fatty Acids; HEK293 Cells; Humans; Lauric Acids; Membrane Proteins; Mice; Mice, Knockout; Mitochondria; Oxidation-Reduction; Palmitic Acid; Peroxisomal Bifunctional Enzyme; Peroxisomal Multifunctional Protein-2; Peroxisomes; Recombinant Proteins | 2019 |
Erythrocyte PUFAs, circulating acylcarnitines, and metabolic syndrome risk: a prospective study in Chinese.
Topics: Aged; Carnitine; China; Erythrocytes; Fatty Acids, Unsaturated; Female; Humans; Male; Metabolic Syndrome; Middle Aged; Prospective Studies; Risk Factors | 2019 |
Analysis of amino acid and acyl carnitine profiles in maternal and fetal serum from preeclampsia patients.
Topics: Adult; Amino Acids; Biomarkers; Carnitine; Case-Control Studies; Chromatography, High Pressure Liquid; Female; Fetal Blood; Humans; Infant, Newborn; Pre-Eclampsia; Pregnancy; Retrospective Studies | 2020 |
Zonisamide Administration Improves Fatty Acid β-Oxidation in Parkinson's Disease.
Topics: Aged; Aged, 80 and over; Antiparkinson Agents; Carnitine; Fatty Acids; Female; Humans; Levodopa; Male; Mental Status and Dementia Tests; Metabolome; Middle Aged; Mitochondria; Oxidation-Reduction; Parkinson Disease; Pilot Projects; Severity of Illness Index; Zonisamide | 2018 |
Metabolic profiling analysis upon acylcarnitines in tissues of hepatocellular carcinoma revealed the inhibited carnitine shuttle system caused by the downregulated carnitine palmitoyltransferase 2.
Topics: Apoptosis; Biomarkers, Tumor; Carcinoma, Hepatocellular; Carnitine; Carnitine O-Palmitoyltransferase; Case-Control Studies; Cell Proliferation; Follow-Up Studies; Humans; Liver Neoplasms; Metabolome; Prognosis; RNA, Small Interfering; Tumor Cells, Cultured | 2019 |
Frontline Science: Monocytes sequentially rewire metabolism and bioenergetics during an acute inflammatory response.
Topics: Amino Acids; Carbohydrate Metabolism; Carnitine; Energy Metabolism; Humans; Inflammation; Lipid Metabolism; Lipopolysaccharides; Metabolome; Monocytes; Nucleotides; Principal Component Analysis; THP-1 Cells | 2019 |
Isotope Labeling Strategies for Acylcarnitines Profile in Biological Samples by Liquid Chromatography-Mass Spectrometry.
Topics: Biomarkers; Butylamines; Carnitine; Chromatography, Liquid; Deuterium; Humans; Isotope Labeling; Pyridinium Compounds; Tandem Mass Spectrometry | 2019 |
Characterizing acyl-carnitine biosignatures for schizophrenia: a longitudinal pre- and post-treatment study.
Topics: Adult; Biomarkers; Carnitine; Case-Control Studies; China; Chromatography, Liquid; Energy Metabolism; Female; Humans; Logistic Models; Male; Middle Aged; Multivariate Analysis; Schizophrenia; Tandem Mass Spectrometry | 2019 |
Clinical and muscle magnetic resonance image findings in patients with late-onset multiple acyl-CoA dehydrogenase deficiency.
Topics: Adolescent; Adult; Biopsy; Carnitine; Electron-Transferring Flavoproteins; Female; Hamstring Muscles; Humans; Iron-Sulfur Proteins; Magnetic Resonance Imaging; Male; Middle Aged; Multiple Acyl Coenzyme A Dehydrogenase Deficiency; Muscle, Skeletal; Oxidoreductases Acting on CH-NH Group Donors; Retrospective Studies; Young Adult | 2019 |
Metabolomic Profiling of Aqueous Humor in Glaucoma Points to Taurine and Spermine Deficiency: Findings from the Eye-D Study.
Topics: Aged; Aged, 80 and over; Amino Acids; Aqueous Humor; Carnitine; Cataract Extraction; Female; Glaucoma, Open-Angle; Humans; Hydroxyproline; Male; Metabolomics; Middle Aged; Spermine; Taurine | 2019 |
Pilot study of myocardial ischemia-induced metabolomic changes in emergency department patients undergoing stress testing.
Topics: Acute Coronary Syndrome; Adult; Aged; Amino Acids; Carnitine; Emergency Service, Hospital; Exercise Test; Female; Humans; Male; Middle Aged; Pilot Projects; Prospective Studies | 2019 |
Age-Specific Cut-off Values of Amino Acids and Acylcarnitines for Diagnosis of Inborn Errors of Metabolism Using Liquid Chromatography Tandem Mass Spectrometry.
Topics: Adolescent; Age Factors; Amino Acids; Carnitine; Child; Child, Preschool; Chromatography, Liquid; Female; Humans; Infant; Infant, Newborn; Male; Metabolism, Inborn Errors; Tandem Mass Spectrometry | 2019 |
Amino acid and fatty acid metabolomic profile during fasting and hyperinsulinemia in girls with polycystic ovarian syndrome.
Topics: Absorptiometry, Photon; Adipose Tissue; Adolescent; Amino Acids; Blood Glucose; Body Composition; Calorimetry, Indirect; Carnitine; Case-Control Studies; Child; Estradiol; Fasting; Fatty Acids; Female; Glucose Clamp Technique; Humans; Hyperinsulinism; Insulin Resistance; Liver; Metabolome; Metabolomics; Mitochondria, Muscle; Muscle, Skeletal; Obesity; Polycystic Ovary Syndrome; Sedentary Behavior; Sex Hormone-Binding Globulin; Testosterone | 2019 |
Metabolomic profiling reveals correlations between spermiogram parameters and the metabolites present in human spermatozoa and seminal plasma.
Topics: Adult; Amino Acids; Biogenic Amines; Carnitine; Centrifugation, Density Gradient; Gas Chromatography-Mass Spectrometry; Humans; Lysophosphatidylcholines; Male; Metabolome; Phosphatidylcholines; Semen; Semen Analysis; Spermatozoa; Sphingomyelins; Sugars | 2019 |
Serum carnitine levels of children with epilepsy: Related factors including valproate.
Topics: Adolescent; Body Mass Index; Carnitine; Child; Child, Preschool; Cognitive Dysfunction; Epilepsy; Female; Humans; Infant; Male; Retrospective Studies; Valproic Acid; Young Adult | 2019 |
Berberine alleviates nonalcoholic fatty liver induced by a high-fat diet in mice by activating SIRT3.
Topics: Acetylation; Acyl-CoA Dehydrogenase, Long-Chain; Animals; Berberine; Carnitine; Diet, High-Fat; Drug Evaluation, Preclinical; Enzyme Activation; Fatty Acids; Glucose; Insulin Resistance; Lipid Metabolism; Male; Metabolome; Mice; Mice, Inbred C57BL; Mice, Knockout; Mitochondria, Liver; Non-alcoholic Fatty Liver Disease; Obesity; Oxidation-Reduction; Protein Processing, Post-Translational; Sirtuin 3 | 2019 |
Subchronic low-dose 2,4-D exposure changed plasma acylcarnitine levels and induced gut microbiome perturbations in mice.
Topics: 2,4-Dichlorophenoxyacetic Acid; Animals; Carnitine; Computational Biology; Environmental Exposure; Gastrointestinal Microbiome; Herbicides; Metabolome; Metabolomics; Metagenome; Mice | 2019 |
Integrated Lipidomics and Metabolomics Analysis of Tears in Multiple Sclerosis: An Insight into Diagnostic Potential of Lacrimal Fluid.
Topics: Adult; Amino Acids; Biomarkers; Carnitine; Central Nervous System; Chromatography, Liquid; Female; Humans; Lacrimal Apparatus; Lipids; Metabolomics; Middle Aged; Multiple Sclerosis; Phospholipids; Tandem Mass Spectrometry; Tears | 2019 |
Peripheral blood metabolite profiles associated with new onset atrial fibrillation.
Topics: Aged; Amino Acids; Atrial Fibrillation; Biomarkers; Carbohydrates; Carnitine; Coronary Angiography; Fatty Acids; Female; Follow-Up Studies; Humans; Male; Middle Aged; Mitochondria, Heart; Principal Component Analysis; Proportional Hazards Models; Risk Factors | 2019 |
Metabolite aberrations in early diabetes detected in rat kidney using mass spectrometry imaging.
Topics: Amino Acids, Branched-Chain; Animals; Carnitine; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Diglycerides; Fatty Acids; Kidney; Lipids; Male; Monoglycerides; Oxidation-Reduction; Rats; Rats, Sprague-Dawley; Spectrometry, Mass, Electrospray Ionization | 2019 |
Plasma acylcarnitines and progression of carotid artery atherosclerosis in HIV infection.
Topics: Adult; Atherosclerosis; Carnitine; Carotid Arteries; Carotid Artery Diseases; Female; HIV Infections; Humans; Longitudinal Studies; Male; Middle Aged; Plasma; Prospective Studies; Risk Factors; Ultrasonography | 2019 |
Implementation of a fast method for the measurement of carnitine palmitoyltransferase 2 activity in lymphocytes by tandem mass spectrometry as confirmation for newborn screening.
Topics: Carnitine; Carnitine O-Palmitoyltransferase; Case-Control Studies; Humans; Infant, Newborn; Lymphocytes; Metabolism, Inborn Errors; Mutation; Neonatal Screening; Tandem Mass Spectrometry | 2019 |
Plasma metabolomic profiling of amino acids and polar lipids in Iranian obese adults.
Topics: Adult; Alcohol Drinking; Amino Acids; Biomarkers; Body Mass Index; Carnitine; Case-Control Studies; Chromatography, Liquid; Exercise; Female; Humans; Iran; Linear Models; Lysophospholipids; Male; Metabolome; Metabolomics; Obesity; Phosphatidylcholines; Smoking; Sphingomyelins; Tandem Mass Spectrometry | 2019 |
Western diet consumption through early life induces microvesicular hepatic steatosis in association with an altered metabolome in low birth weight Guinea pigs.
Topics: Animals; Animals, Newborn; Birth Weight; Carnitine; Diet, Western; Fatty Acids; Female; Guinea Pigs; Lipogenesis; Liver; Metabolome; Non-alcoholic Fatty Liver Disease; Placental Insufficiency; Pregnancy; Weight Gain | 2019 |
Flavin adenine dinucleotide synthase deficiency due to FLAD1 mutation presenting as multiple acyl-CoA dehydrogenation deficiency-like disease: A case report.
Topics: Acyl Coenzyme A; Carnitine; Child, Preschool; Codon, Nonsense; Electron-Transferring Flavoproteins; Flavin-Adenine Dinucleotide; Humans; Male; Membrane Transport Proteins; Multiple Acyl Coenzyme A Dehydrogenase Deficiency; Mutation; Receptors, G-Protein-Coupled; Riboflavin | 2019 |
Acylcarnitine profile in neonatal hypoxic-ischemic encephalopathy: The value of butyrylcarnitine as a prognostic marker.
Topics: Biomarkers; Brain; Carnitine; Female; Humans; Hypoxia-Ischemia, Brain; Infant, Newborn; Male; Phosphopyruvate Hydratase; Prognosis; Retrospective Studies | 2019 |
A nationwide retrospective observational study of population newborn screening for medium-chain acyl-CoA dehydrogenase (MCAD) deficiency in the Netherlands.
Topics: Acyl-CoA Dehydrogenase; Carnitine; Female; Genotype; Humans; Infant, Newborn; Lipid Metabolism, Inborn Errors; Male; Neonatal Screening; Netherlands; Prevalence; Retrospective Studies | 2019 |
The Impact of OMEGA-3 Fatty Acids Supplementation on Insulin Resistance and Content of Adipocytokines and Biologically Active Lipids in Adipose Tissue of High-Fat Diet Fed Rats.
Topics: Adiponectin; Adipose Tissue; Animals; Blood Glucose; Carnitine; Carnitine O-Palmitoyltransferase; Ceramides; Diet, High-Fat; Dietary Supplements; Diglycerides; Enzyme-Linked Immunosorbent Assay; Fatty Acids, Omega-3; Fish Oils; Insulin; Insulin Resistance; Intra-Abdominal Fat; Lipid Metabolism; Male; Obesity; Polymerase Chain Reaction; Random Allocation; Rats, Wistar; Subcutaneous Fat | 2019 |
The association between newborn screening analytes and childhood autism in a Texas Medicaid population, 2010-2012.
Topics: 17-alpha-Hydroxyprogesterone; Autism Spectrum Disorder; Autistic Disorder; Carnitine; Case-Control Studies; Child, Preschool; Female; Humans; Infant; Infant, Newborn; Male; Medicaid; Neonatal Screening; Pilot Projects; Texas; United States | 2019 |
Effect of Acetyl-L-carnitine Used for Protection of Neonatal Hypoxic-Ischemic Brain Injury on Acute Kidney Changes in Male and Female Rats.
Topics: Acetylcarnitine; Animals; Animals, Newborn; Biological Transport; Brain; Brain Injuries; Carnitine; Female; Hypoxia; Hypoxia-Ischemia, Brain; Kidney; Male; Rats, Sprague-Dawley | 2019 |
SIRT3 controls brown fat thermogenesis by deacetylation regulation of pathways upstream of UCP1.
Topics: 3-Hydroxyacyl CoA Dehydrogenases; Acetyl-CoA C-Acyltransferase; Acetylation; Adipose Tissue, Brown; Adrenergic beta-3 Receptor Antagonists; Animals; Body Composition; Body Temperature Regulation; Carbon-Carbon Double Bond Isomerases; Carnitine; Enoyl-CoA Hydratase; HEK293 Cells; Humans; Male; Mice; Mice, Knockout; Mitochondria; Mitochondrial Proteins; Models, Animal; Mutagenesis; Oxidative Phosphorylation; Proteomics; Racemases and Epimerases; Sirtuin 3; Thermogenesis; Uncoupling Protein 1 | 2019 |
Dynamic modelling of an ACADS genotype in fatty acid oxidation - Application of cellular models for the analysis of common genetic variants.
Topics: Acyl-CoA Dehydrogenase; Carnitine; Cell Line, Tumor; Fatty Acids; Female; Genetic Variation; Genome-Wide Association Study; Genotype; Hepatocytes; Humans; Male; Middle Aged; Mitochondria; Oxidation-Reduction; Phenotype | 2019 |
A comprehensive protocol for multiplatform metabolomics analysis in patient-derived skin fibroblasts.
Topics: Amino Acids; Carnitine; Cells, Cultured; Chromatography, Liquid; Citric Acid Cycle; Fibroblasts; Gas Chromatography-Mass Spectrometry; Humans; Metabolome; Metabolomics; Skin | 2019 |
Seminal plasma metabolome in relation to semen quality and urinary phthalate metabolites among Chinese adult men.
Topics: Adult; Asian People; Carnitine; Chromatography, Liquid; Cross-Sectional Studies; Diethylhexyl Phthalate; Humans; Male; Metabolome; Phthalic Acids; Semen; Semen Analysis; Spermatozoa; Tandem Mass Spectrometry | 2019 |
External Quality Assessment Program for Newborn Screening of Acylcarnitine in China, 2018.
Topics: Carnitine; China; Humans; Infant, Newborn; Laboratories; Neonatal Screening; Quality Assurance, Health Care; Quality Control; Reference Values; Reproducibility of Results; Tandem Mass Spectrometry | 2019 |
Associations of Amino Acid and Acylcarnitine Profiles With Incident Hyperuricemia in Middle-Aged and Older Chinese Individuals.
Topics: Aged; Amino Acids; Carnitine; China; Female; Humans; Hyperuricemia; Incidence; Male; Middle Aged; Risk Factors; Uric Acid | 2020 |
Carnitine palmitoyl transferase 1A deficiency in an adult with recurrent severe steato hepatitis aggravated by high pathologic or physiologic demands: A roller-coaster for internists.
Topics: Adult; Anti-Bacterial Agents; Carnitine; Carnitine O-Palmitoyltransferase; Escherichia coli Infections; Humans; Hypoglycemia; Lipid Metabolism, Inborn Errors; Liver; Male; Mutation, Missense; Non-alcoholic Fatty Liver Disease; Recurrence; Severity of Illness Index | 2019 |
Prediction of disease severity in multiple acyl-CoA dehydrogenase deficiency: A retrospective and laboratory cohort study.
Topics: Carnitine; Fatty Acids; Female; Humans; Infant, Newborn; Male; Multiple Acyl Coenzyme A Dehydrogenase Deficiency; Retrospective Studies; Severity of Illness Index | 2019 |
Lipid Emulsion Containing High Amounts of n3 Fatty Acids (Omegaven) as Opposed to n6 Fatty Acids (Intralipid) Preserves Insulin Signaling and Glucose Uptake in Perfused Rat Hearts.
Topics: Animals; Carnitine; Emulsions; Energy Metabolism; Fat Emulsions, Intravenous; Fish Oils; Glucose; Insulin; Isolated Heart Preparation; Myocytes, Cardiac; NF-kappa B; Oxidation-Reduction; Phosphofructokinase-1; Phosphofructokinase-2; Phospholipids; Phosphorylation; Protein Phosphatase 2; Proto-Oncogene Proteins c-akt; Rats, Sprague-Dawley; Signal Transduction; Soybean Oil; Triglycerides | 2020 |
Comprehensive Metabolomic Analysis of IDH1
Topics: Adult; Aged; Biomarkers, Tumor; Brain Neoplasms; Carnitine; Cell Division; Cell Line, Tumor; Female; Glioblastoma; Glutarates; Humans; Isocitrate Dehydrogenase; Male; Metabolomics; Middle Aged; Mutation; Oxidation-Reduction; Prognosis; Signal Transduction; Transfection | 2019 |
Changes in pediatric plasma acylcarnitines upon fasting for refined interpretation of metabolic stress.
Topics: Blood Glucose; Carnitine; Child; Child, Preschool; Fasting; Female; Homeostasis; Humans; Hypoglycemia; Infant; Lipid Metabolism, Inborn Errors; Male; Retrospective Studies; Stress, Physiological | 2019 |
Hydroxylated Long-Chain Acylcarnitines are Biomarkers of Mitochondrial Myopathy.
Topics: Acyl Coenzyme A; Acyl-CoA Dehydrogenase; Adult; Biomarkers; Carnitine; Cohort Studies; Denmark; Female; Humans; Hydroxylation; Male; Middle Aged; Mitochondrial Myopathies; Mixed Function Oxygenases; Oxidation-Reduction; Prospective Studies | 2019 |
Metabolomic Studies of Tissue Injury in Nonhuman Primates Exposed to Gamma-Radiation.
Topics: Animals; Biomarkers; Carnitine; Female; Gamma Rays; Gene Expression; In Vitro Techniques; Kidney; Lipidomics; Macaca mulatta; Male; Metabolomics; Primates; Radiation, Ionizing | 2019 |
Inter-generational link of obesity in term and preterm births: role of maternal plasma acylcarnitines.
Topics: Adolescent; Adult; Biomarkers; Body Mass Index; Boston; Carnitine; Child; Child, Preschool; Female; Humans; Infant; Infant, Newborn; Male; Mothers; Obesity; Pediatric Obesity; Pregnancy; Premature Birth; Prenatal Exposure Delayed Effects; Prospective Studies | 2019 |
Altered serum acylcarnitine profile is associated with the status of nonalcoholic fatty liver disease (NAFLD) and NAFLD-related hepatocellular carcinoma.
Topics: Adult; Age Factors; Aged; Carcinoma, Hepatocellular; Carnitine; Disease Progression; Female; Humans; Liver; Liver Cirrhosis; Liver Neoplasms; Male; Middle Aged; Non-alcoholic Fatty Liver Disease | 2019 |
Tryptophan 224 of the rat mitochondrial carnitine/acylcarnitine carrier is crucial for the antiport mechanism.
Topics: Amino Acid Sequence; Animals; Antiporters; Aspergillus nidulans; Biological Transport; Carnitine; Carnitine Acyltransferases; Models, Molecular; Mutagenesis, Site-Directed; Mutant Proteins; Mutation; Protein Conformation; Rats; Recombinant Proteins; Sequence Homology; Tryptophan | 2019 |
Lipidomics unveils lipid dyshomeostasis and low circulating plasmalogens as biomarkers in a monogenic mitochondrial disorder.
Topics: Adolescent; Animals; Bile Acids and Salts; Biomarkers; Carnitine; Case-Control Studies; Disease Models, Animal; Female; Humans; Leigh Disease; Lipid Metabolism; Lipidomics; Liver; Male; Mice; Mice, Knockout; Mitochondria; Mutation; Neoplasm Proteins; Peroxisomes; Plasmalogens; Prospective Studies; Young Adult | 2019 |
Novel Markers of the Metabolic Impact of Exogenous Retinoic Acid with A Focus on Acylcarnitines and Amino Acids.
Topics: Adipose Tissue; Amino Acids; Animals; Carnitine; Gene Expression Profiling; Leukocytes, Mononuclear; Lipid Metabolism; Lipids; Male; Metabolome; Metabolomics; Mice; Models, Biological; Oxidation-Reduction; Tretinoin | 2019 |
Fatty Acid Metabolites Combine with Reduced β Oxidation to Activate Th17 Inflammation in Human Type 2 Diabetes.
Topics: Adult; Aged; Carnitine; Carnitine O-Palmitoyltransferase; Cells, Cultured; Cross-Sectional Studies; Cytokines; Diabetes Mellitus, Type 2; Fatty Acids; Female; Gene Knockdown Techniques; Glycolysis; Humans; Inflammation; Lymphocyte Activation; Male; Membrane Transport Proteins; Middle Aged; Obesity; Oxidation-Reduction; Th17 Cells; Transfection; Young Adult | 2019 |
FLAD1-associated multiple acyl-CoA dehydrogenase deficiency identified by newborn screening.
Topics: Carnitine; Female; Humans; Infant, Newborn; Multiple Acyl Coenzyme A Dehydrogenase Deficiency; Mutation; Nucleotidyltransferases; Riboflavin | 2019 |
Merged Targeted Quantification and Untargeted Profiling for Comprehensive Assessment of Acylcarnitine and Amino Acid Metabolism.
Topics: Amino Acids; Brain; Brain Chemistry; Calibration; Carnitine; Chromatography, Liquid; Humans; Hydrophobic and Hydrophilic Interactions; Isotope Labeling; Limit of Detection; Mass Spectrometry; Metabolome; Reproducibility of Results | 2019 |
Matrix-Assisted Laser Desorption/Ionization-Mass Spectrometry Imaging of Lipids in Experimental Model of Traumatic Brain Injury Detecting Acylcarnitines as Injury Related Markers.
Topics: Animals; Biomarkers; Brain; Brain Injuries, Traumatic; Carnitine; Disease Models, Animal; Image Processing, Computer-Assisted; Lipid Metabolism; Lipids; Male; Microglia; Palmitoylcarnitine; Rats, Sprague-Dawley; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Tandem Mass Spectrometry | 2019 |
Acylcarnitine profiling by low-resolution LC-MS.
Topics: Animals; Carnitine; Chromatography, Liquid; Mass Spectrometry; Mice | 2019 |
Mass Spectrometry Fingerprints of Small-Molecule Metabolites in Biofluids: Building a Spectral Library of Recurrent Spectra for Urine Analysis.
Topics: Body Fluids; Carnitine; Chromatography, Liquid; Humans; Mass Spectrometry; Neoplasms; Small Molecule Libraries; Software | 2019 |
Effect of high-fat diet on peripheral blood mononuclear cells and adipose tissue in early stages of diet-induced weight gain.
Topics: Animals; Autophagy; Carnitine; Diet, High-Fat; Homeostasis; Inflammation; Insulin; Insulin Resistance; Leukocytes, Mononuclear; Lipid Metabolism; Liver; Male; Obesity; Rabbits; Subcutaneous Fat; Weight Gain | 2019 |
Diagnostic contribution of metabolic workup for neonatal inherited metabolic disorders in the absence of expanded newborn screening.
Topics: Amino Acids; Carnitine; Female; Humans; Infant; Infant, Newborn; Infant, Newborn, Diseases; Intensive Care Units, Neonatal; Male; Maple Syrup Urine Disease; Metabolic Diseases; Neonatal Screening; Paris; Phenylketonurias; Propionic Acidemia | 2019 |
Metabolism of fatty acids and bile acids in plasma is associated with overactive bladder in males: potential biomarkers and targets for novel treatments in a metabolomics analysis.
Topics: Aged; Biomarkers; Carnitine; Case-Control Studies; Cholic Acid; Erucic Acids; Fatty Acids; Fatty Acids, Monounsaturated; Humans; Male; Metabolomics; Nocturia; Urinary Bladder, Overactive; Urine | 2020 |
Exogenous carnitine application augments transport of fatty acids into mitochondria and stimulates mitochondrial respiration in maize seedlings grown under normal and cold conditions.
Topics: Animals; Biological Transport; Carnitine; Carnitine O-Palmitoyltransferase; Citrate (si)-Synthase; Cold Temperature; Cold-Shock Response; Cryopreservation; Electron Transport Complex IV; Fatty Acids; Laurates; Mitochondria; Oxidation-Reduction; Seedlings; Zea mays | 2019 |
Severe clinical manifestation of mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase deficiency associated with two novel mutations: a case report.
Topics: Acidosis; Acyl Coenzyme A; Adipates; Carnitine; Diarrhea; Dicarboxylic Acids; Exome Sequencing; Fatal Outcome; Frameshift Mutation; Glutarates; Humans; Hydroxymethylglutaryl-CoA Synthase; Infant; Male; Mitochondria; Multiple Organ Failure; Mutation; Respiratory Tract Infections | 2019 |
Associations with metabolites in Chinese suggest new metabolic roles in Alzheimer's and Parkinson's diseases.
Topics: Alzheimer Disease; Asian People; ATP-Binding Cassette Transporters; Carnitine; China; DNA-Binding Proteins; Female; Galactosyltransferases; Genetic Loci; Genetic Predisposition to Disease; Genome-Wide Association Study; Glutathione Transferase; Glycosphingolipids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Liver-Specific Organic Anion Transporter 1; Lysophospholipids; Male; Membrane Proteins; Middle Aged; Parkinson Disease; Phosphoric Monoester Hydrolases; Serine; Serine C-Palmitoyltransferase; Sphingolipids; Sphingosine; Tandem Mass Spectrometry; Transcription Factors | 2020 |
Clinical and lifestyle related factors influencing whole blood metabolite levels - A comparative analysis of three large cohorts.
Topics: Adult; Aged; Amino Acids; Carnitine; Chromatography, High Pressure Liquid; Cohort Studies; Coronary Artery Disease; Female; Humans; Life Style; Linear Models; Male; Metabolic Networks and Pathways; Metabolome; Middle Aged; Tandem Mass Spectrometry | 2019 |
MET Inhibition Elicits PGC1α-Dependent Metabolic Reprogramming in Glioblastoma.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Carnitine; Cell Line, Tumor; Cell Proliferation; Cell Respiration; Crizotinib; Drug Synergism; Epoxy Compounds; Fatty Acids; Gene Expression Profiling; Glioblastoma; Glycolysis; Guanidines; Humans; Lactams, Macrocyclic; Metabolomics; Mice; Mitochondria; Mitochondrial Dynamics; Oxidative Phosphorylation; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; Proteomics; Proto-Oncogene Proteins c-met; Reactive Oxygen Species; Xenograft Model Antitumor Assays | 2020 |
Knockout of the non-essential gene SUGCT creates diet-linked, age-related microbiome disbalance with a diabetes-like metabolic syndrome phenotype.
Topics: Aging; Animals; Anti-Bacterial Agents; Bacteria; Carnitine; Coenzyme A-Transferases; Dietary Supplements; Feces; Gastrointestinal Microbiome; Humans; Kidney; Lipid Metabolism; Liver; Lysine; Metabolic Syndrome; Metabolome; Mice; Mice, Knockout; Obesity; Tryptophan | 2020 |
The Use of DMS-MS for the Quantitative Analysis of Acylcarnitines.
Topics: Carnitine; Humans; Ion Mobility Spectrometry; Mass Spectrometry | 2020 |
A Prospective Repurposing of Dantrolene as a Multitarget Agent for Alzheimer's Disease.
Topics: Acetylcholinesterase; Alzheimer Disease; Calcium; Calcium Channel Blockers; Carnitine; Cell Line; Cholinesterase Inhibitors; Dantrolene; Drug Repositioning; Humans; Malignant Hyperthermia; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Neuroprotective Agents | 2019 |
Systemic and central nervous system metabolic alterations in Alzheimer's disease.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Amyloid beta-Peptides; Biomarkers; Brain; Carnitine; Case-Control Studies; Energy Metabolism; Female; Humans; Male; Metabolomics; Middle Aged; Phosphorylation; tau Proteins; Tryptophan | 2019 |
Adolescent Hyperuricemia with Lipid Storage Myopathy: A Clinical Study.
Topics: Adolescent; Adult; Carnitine; Child; China; Electron-Transferring Flavoproteins; Female; Humans; Hyperuricemia; Iron-Sulfur Proteins; Lipid Metabolism, Inborn Errors; Male; Muscle Weakness; Muscle, Skeletal; Muscular Diseases; Muscular Dystrophies; Oxidoreductases Acting on CH-NH Group Donors; Quality of Life; Riboflavin; Young Adult | 2019 |
Brain and blood metabolome for Alzheimer's dementia: findings from a targeted metabolomics analysis.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Biomarkers; Brain; Carnitine; Cognition; Cohort Studies; Female; Follow-Up Studies; Humans; Longitudinal Studies; Male; Metabolome; Metabolomics; Middle Aged; Risk | 2020 |
One potential hotspot ACADVL mutation in Chinese patients with very-long-chain acyl-coenzyme A dehydrogenase deficiency.
Topics: Acyl-CoA Dehydrogenase, Long-Chain; Asian People; Carnitine; China; Congenital Bone Marrow Failure Syndromes; Female; Humans; Hypoglycemia; Infant, Newborn; Lipid Metabolism, Inborn Errors; Liver Diseases; Male; Mitochondrial Diseases; Muscular Diseases; Mutation | 2020 |
Homozygous B4GALNT1 mutation and biochemical glutaric acidemia type II: A case report.
Topics: Adult; Carnitine; Epilepsy, Temporal Lobe; Female; Frameshift Mutation; Homozygote; Humans; Intellectual Disability; Multiple Acyl Coenzyme A Dehydrogenase Deficiency; N-Acetylgalactosaminyltransferases; Spastic Paraplegia, Hereditary | 2020 |
Plasma metabolomics in tuberculosis patients with and without concurrent type 2 diabetes at diagnosis and during antibiotic treatment.
Topics: Adult; Amines; Anti-Bacterial Agents; Blood Proteins; Body Weight; Carnitine; Chromatography, Liquid; Diabetes Mellitus, Type 2; Female; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Indonesia; Least-Squares Analysis; Male; Metabolomics; Middle Aged; Nitric Oxide Synthase; Principal Component Analysis; ROC Curve; Tandem Mass Spectrometry; Tuberculosis, Pulmonary; Young Adult | 2019 |
Preoperative plasma fatty acid metabolites inform risk of prostate cancer progression and may be used for personalized patient stratification.
Topics: Aged; Carnitine; Case-Control Studies; Chromatography, Liquid; Disease Progression; Fatty Acids; Humans; Male; Mass Spectrometry; Metabolomics; Middle Aged; Prognosis; Prostatic Neoplasms; White People | 2019 |
Slc22a5 haploinsufficiency does not aggravate the phenotype of the long-chain acyl-CoA dehydrogenase KO mouse.
Topics: Acyl-CoA Dehydrogenase, Long-Chain; Animals; Cardiomyopathies; Carnitine; Disease Models, Animal; Fatty Acids; Female; Haploinsufficiency; Hyperammonemia; Lipid Metabolism; Liver; Male; Mice; Mice, Knockout; Muscular Diseases; Myocardium; Phenotype; Solute Carrier Family 22 Member 5 | 2020 |
Metabolic and lipidomic characterization of malignant pleural effusion in human lung cancer.
Topics: Adenocarcinoma; Biomarkers, Tumor; Carnitine; Chromatography, Liquid; Down-Regulation; Fatty Acids, Unsaturated; Female; Humans; Lipid Metabolism; Lipidomics; Lung Neoplasms; Male; Mass Spectrometry; Metabolome; Metabolomics; Middle Aged; Multivariate Analysis; Pleural Effusion, Malignant; Up-Regulation | 2020 |
Stimulating pyruvate dehydrogenase complex reduces itaconate levels and enhances TCA cycle anabolic bioenergetics in acutely inflamed monocytes.
Topics: Algorithms; Amino Acids; Carnitine; Citric Acid Cycle; Cytokines; Energy Metabolism; Humans; Inflammation; Ketones; Lipopolysaccharides; Metabolome; Monocytes; Principal Component Analysis; Pyruvate Dehydrogenase Complex; Succinates; THP-1 Cells | 2020 |
Genetic deletion of gpr27 alters acylcarnitine metabolism, insulin sensitivity, and glucose homeostasis in zebrafish.
Topics: Animals; Carnitine; Carnitine O-Palmitoyltransferase; Gene Deletion; Glucose; Homeostasis; Insulin; Insulin Resistance; Proto-Oncogene Proteins c-akt; Receptors, G-Protein-Coupled; Signal Transduction; Zebrafish | 2020 |
Loss of function in the Drosophila clock gene period results in altered intermediary lipid metabolism and increased susceptibility to starvation.
Topics: Animals; Biomarkers; Carnitine; Circadian Clocks; Circadian Rhythm; Drosophila melanogaster; Drosophila Proteins; Feeding Behavior; Lipid Metabolism; Lipids; Loss of Function Mutation; Male; Metabolome; Motor Activity; Period Circadian Proteins; Starvation; Stress, Physiological; Tryptophan | 2020 |
Potential osteomyelitis biomarkers identified by plasma metabolome analysis in mice.
Topics: Animals; Biomarkers; Carnitine; Citric Acid Cycle; Disease Models, Animal; Fatty Acids; Ketoglutaric Acids; Luminescent Measurements; Male; Metabolome; Mice, Inbred BALB C; Osteomyelitis; Sphingolipids; Sphingosine; Staphylococcal Infections; Staphylococcus aureus; Succinic Acid; Surgical Wound Infection | 2020 |
Evaluation of a panel of very long-chain lysophosphatidylcholines and acylcarnitines for screening of X-linked adrenoleukodystrophy in China.
Topics: Adrenoleukodystrophy; Age Factors; Biomarkers; Carnitine; Case-Control Studies; Child; Dried Blood Spot Testing; Female; Genetic Diseases, X-Linked; Humans; Infant, Newborn; Lysophosphatidylcholines; Male; Mass Screening; Tandem Mass Spectrometry | 2020 |
Serum acylcarnitine profile in endurance horses with and without metabolic dysfunction.
Topics: Animals; Carnitine; Fatty Acids; Female; Horses; Male; Metabolic Diseases; Mitochondria; Oxidation-Reduction; Physical Endurance; Running; Tandem Mass Spectrometry | 2020 |
Quantitation of Urinary Acylcarnitines by DMS-MS/MS Uncovers the Effects of Total Body Irradiation in Cancer Patients.
Topics: Animals; Biomarkers; Carnitine; Humans; Neoplasms; Pilot Projects; Rats, Sprague-Dawley; Tandem Mass Spectrometry; Whole-Body Irradiation | 2020 |
Metabolomic Analysis of the Liver of a Dextran Sodium Sulfate-Induced Acute Colitis Mouse Model: Implications of the Gut-Liver Connection.
Topics: Acute Disease; Animals; Body Weight; Carnitine; Colitis; Colon; Discriminant Analysis; Disease Models, Animal; Gastrointestinal Tract; Least-Squares Analysis; Liver; Male; Metabolome; Metabolomics; Mice, Inbred BALB C; Multivariate Analysis; Proton Magnetic Resonance Spectroscopy; Rats; Sulfates | 2020 |
Acylcarnitines at the Membrane Surface: Insertion Parameters for a Mitochondrial Leaflet Model.
Topics: Carnitine; Membranes; Mitochondrial Membranes; Static Electricity | 2020 |
Exercise with food withdrawal at thermoneutrality impacts fuel use, the microbiome, AMPK phosphorylation, muscle fibers, and thyroid hormone levels in rats.
Topics: AMP-Activated Protein Kinase Kinases; Animals; Carnitine; Energy Metabolism; Fasting; Gastrointestinal Microbiome; Ketone Bodies; Lipid Metabolism; Liver; Male; Motor Activity; Muscle Fibers, Skeletal; Phosphorylation; Protein Kinases; Rats; Rats, Wistar; Temperature; Thyroid Hormones | 2020 |
Analysis of amino acids and acylcarnitines profiles in small, appropriate, and large for gestational age neonates.
Topics: Amino Acids; Birth Weight; Carnitine; Gestational Age; Humans; Infant, Newborn; Infant, Newborn, Diseases; Infant, Small for Gestational Age | 2022 |
Increased antioxidant response in medium-chain acyl-CoA dehydrogenase deficiency: does lipoic acid have a protective role?
Topics: Acyl-CoA Dehydrogenase; Antioxidants; Caprylates; Carnitine; Cell Death; Fibroblasts; Genotype; Glycolysis; Humans; Lipid Metabolism, Inborn Errors; Lipid Peroxidation; Mitochondria; Oxidative Stress; Phenotype; Superoxides; Thioctic Acid | 2020 |
Acylcarnitine metabolomic profiles inform clinically-defined major depressive phenotypes.
Topics: Carnitine; Depressive Disorder, Major; Humans; Phenotype; Retrospective Studies | 2020 |
Effects of the Menstrual Cycle on Serum Carnitine and Endurance Performance of Women.
Topics: Carnitine; Estradiol; Exercise; Exercise Test; Female; Follicular Phase; Humans; Luteal Phase; Physical Endurance; Progesterone; Young Adult | 2020 |
Targeted Metabolomics Analysis Reveals that Dietary Supranutritional Selenium Regulates Sugar and Acylcarnitine Metabolism Homeostasis in Pig Liver.
Topics: Animals; Carnitine; Diabetes Mellitus, Type 2; Diet; Dietary Supplements; Dose-Response Relationship, Drug; Homeostasis; Hyperglycemia; Hyperinsulinism; Lipids; Liver; Male; Metabolomics; Models, Animal; Oxidation-Reduction; RNA, Messenger; Selenium; Selenomethionine; Selenoproteins; Sugars; Sus scrofa | 2020 |
Prediction of VLCAD deficiency phenotype by a metabolic fingerprint in newborn screening bloodspots.
Topics: Acyl-CoA Dehydrogenase, Long-Chain; Carnitine; Child; Child, Preschool; Congenital Bone Marrow Failure Syndromes; Dried Blood Spot Testing; Female; Humans; Infant; Infant, Newborn; Lipid Metabolism, Inborn Errors; Male; Mass Spectrometry; Metabolomics; Mitochondrial Diseases; Muscular Diseases; Neonatal Screening; Phenotype | 2020 |
Blood carnitine profiling on tandem mass spectrometry in liver cirrhotic patients.
Topics: Adult; Aged; Aged, 80 and over; Carnitine; Female; Humans; Liver Cirrhosis; Male; Middle Aged; Surveys and Questionnaires; Tandem Mass Spectrometry | 2020 |
Simultaneous quantification of free fatty acids and acylcarnitines in plasma samples using dansylhydrazine labeling and liquid chromatography-triple quadrupole mass spectrometry.
Topics: Carbon Isotopes; Carnitine; Chromatography, Liquid; Dansyl Compounds; Humans; Hydrazines; Isotope Labeling; Tandem Mass Spectrometry | 2020 |
Identification and regulation of the xenometabolite derivatives
Topics: Carnitine; Exercise; Humans; Male; Muscle, Skeletal; Young Adult | 2020 |
Neonatal Macrosomia is an Interfering Factor for Analytes on the Colorado State Newborn Screen.
Topics: Adult; Amino Acid Metabolism, Inborn Errors; Carnitine; Carnitine O-Palmitoyltransferase; Colorado; False Positive Reactions; Female; Fetal Macrosomia; Humans; Infant, Newborn; Infant, Newborn, Diseases; Male; Metabolism, Inborn Errors; Neonatal Screening; Pediatric Obesity; Pregnancy; Propionic Acidemia; Tandem Mass Spectrometry | 2020 |
Rare variants and biological pathways identified in treatment-refractory depression.
Topics: Adolescent; Adult; Alleles; Biopterins; Carnitine; Computer Simulation; Depressive Disorder, Treatment-Resistant; Exome Sequencing; Female; Genetic Predisposition to Disease; Humans; Male; Phenotype; Polymorphism, Single Nucleotide; Tetrahydrofolates; Young Adult | 2020 |
Post-mortem tissue analyses in a patient with succinic semialdehyde dehydrogenase deficiency (SSADHD). I. Metabolomic outcomes.
Topics: Adult; Amino Acid Metabolism, Inborn Errors; Amino Acids; Brain; Carnitine; Creatine; Creatinine; Developmental Disabilities; gamma-Aminobutyric Acid; Glycine; Humans; Male; Metabolomics; Succinate-Semialdehyde Dehydrogenase | 2020 |
Metabolic profiling by reversed-phase/ion-exchange mass spectrometry.
Topics: Amino Acids; Bile Acids and Salts; Carnitine; Chromatography, High Pressure Liquid; Chromatography, Ion Exchange; Chromatography, Reverse-Phase; Hormones; Humans; Hydrophobic and Hydrophilic Interactions; Isoleucine; Metabolome; Metabolomics; Methylmalonic Acid; Nucleosides; Small Molecule Libraries; Succinic Acid; Tandem Mass Spectrometry; Vitamins | 2020 |
Plasma Metabolomic Markers of Insulin Resistance and Diabetes and Rate of Incident Parkinson's Disease.
Topics: Adult; Aged; Biomarkers; Carnitine; Diabetes Mellitus; Female; Humans; Insulin Resistance; Male; Metabolomics; Middle Aged; Parkinson Disease; Plasma; Risk Factors | 2020 |
Carnitine palmitoyltransferase 1C contributes to progressive cellular senescence.
Topics: Animals; Carcinogenesis; Carcinoma; Carnitine; Carnitine O-Palmitoyltransferase; Cell Line, Tumor; Cell Movement; Cell Proliferation; Cell Survival; Cellular Senescence; Cyclin-Dependent Kinase Inhibitor p21; DNA-Binding Proteins; Gene Expression Regulation; Genetic Vectors; Humans; Male; Metabolomics; Mice; Mitochondria; Mitochondrial Proteins; Mitophagy; Neoplasm Transplantation; Nuclear Respiratory Factor 1; Pancreatic Neoplasms; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; PPAR alpha; Protein Transport; RNA, Messenger; Signal Transduction; Telomere Shortening; Transcription Factors; Tumor Suppressor Proteins | 2020 |
Inborn errors of metabolism detectable by tandem mass spectrometry in Beijing.
Topics: Amino Acids; Beijing; Carnitine; Female; Humans; Infant, Newborn; Male; Metabolism, Inborn Errors; Neonatal Screening; Tandem Mass Spectrometry | 2020 |
Relationship between the plasma acylcarnitine profile and cardiometabolic risk factors in adults diagnosed with cardiovascular diseases.
Topics: Adult; Aged; Cardiometabolic Risk Factors; Cardiovascular Diseases; Carnitine; Female; Humans; Male; Middle Aged | 2020 |
Contributions of amino acid, acylcarnitine and sphingolipid profiles to type 2 diabetes risk among South-Asian Surinamese and Dutch adults.
Topics: Adult; Amino Acids; Carnitine; Diabetes Mellitus, Type 2; Ethnicity; Humans; Netherlands; Sphingolipids | 2020 |
The Association Between Acylcarnitine Metabolites and Cardiovascular Disease in Chinese Patients With Type 2 Diabetes Mellitus.
Topics: Aged; Biomarkers; Cardiovascular Diseases; Carnitine; Cross-Sectional Studies; Diabetes Mellitus, Type 2; Female; Follow-Up Studies; Humans; Male; Metabolome; Middle Aged; Prognosis | 2020 |
Sexual Dimorphism in Energy Metabolism of Wistar Rats Using Data Analysis.
Topics: Amino Acids; Animals; Biomarkers; Carnitine; Data Analysis; Discriminant Analysis; Energy Metabolism; Female; Male; Metabolome; Metabolomics; Phenylalanine; Rats; Sex Characteristics; Tyrosine | 2020 |
Metabolomics of a mouse model of preeclampsia induced by overexpressing soluble fms-like tyrosine kinase 1.
Topics: Animals; Carnitine; Cell Line; Disease Models, Animal; Fatty Acids; Female; Fetal Growth Retardation; Glycolysis; Humans; Metabolomics; Mice; Mice, Inbred ICR; Placenta; Pre-Eclampsia; Pregnancy; Up-Regulation; Vascular Endothelial Growth Factor Receptor-1 | 2020 |
Determination of carnitine ester profile in the children with type 1 diabetes: a valuable step towards a better management.
Topics: Amino Acids; Carnitine; Child; Coenzyme A; Diabetes Mellitus, Type 1; Esters; Fatty Acids; Female; Glycated Hemoglobin; Humans; Isotopes; Male | 2022 |
Association Between the Serum Carnitine Level and Ammonia and Valproic Acid Levels in Patients with Bipolar Disorder.
Topics: Ammonia; Anticonvulsants; Bipolar Disorder; Carnitine; Epilepsy; Female; Humans; Male; Middle Aged; Retrospective Studies; Valproic Acid | 2020 |
Metabolic Effects of Gastric Bypass Surgery: Is It All About Calories?
Topics: Adult; Blood Glucose; Caloric Restriction; Carnitine; Diabetes Mellitus, Type 2; Fasting; Female; Gastric Bypass; Humans; Insulin; Insulin Resistance; Middle Aged; Obesity, Morbid; Postprandial Period | 2020 |
Targeted Metabolomic Analysis of a Mucopolysaccharidosis IIIB Mouse Model Reveals an Imbalance of Branched-Chain Amino Acid and Fatty Acid Metabolism.
Topics: Amino Acids, Aromatic; Amino Acids, Branched-Chain; Animals; Carnitine; Disease Models, Animal; Humans; Lipid Metabolism; Liver; Male; Metabolomics; Mice; Mucopolysaccharidosis III; Myocardium | 2020 |
Plasma acylcarnitine levels increase with healthy aging.
Topics: Adult; Age Factors; Aged; Aged, 80 and over; Carnitine; Cross-Sectional Studies; Energy Metabolism; Fasting; Feasibility Studies; Female; Healthy Aging; Healthy Volunteers; Humans; Male; Metabolomics; Middle Aged; Mitochondria; Oxidation-Reduction; Sex Factors; Young Adult | 2020 |
HDAC11 is a novel regulator of fatty acid oxidative metabolism in skeletal muscle.
Topics: AMP-Activated Protein Kinases; Animals; Carnitine; Energy Metabolism; Fatty Acids; Gene Expression Regulation; Glycolysis; Histone Deacetylases; Mice, Inbred C57BL; Mice, Knockout; Mitochondria, Muscle; Muscle Fibers, Skeletal; Muscle, Skeletal; Oxidation-Reduction | 2021 |
Does metabolomic profile differ with regard to birth weight?
Topics: Birth Weight; Carnitine; Female; Humans; Iceland; Infant, Newborn; Male; Metabolomics; Neonatal Screening | 2021 |
Intramuscular short-chain acylcarnitines in elderly people are decreased in (pre-)frail females, but not in males.
Topics: Aged; Aged, 80 and over; Aging; Carnitine; Cross-Sectional Studies; Female; Frail Elderly; Frailty; Hand Strength; Humans; Male; Muscles; Physical Fitness; Sex Factors; Walking | 2020 |
Relationship between fermented dairy consumption, circulating short-chain acylcarnitines and angiographic severity of coronary artery disease.
Topics: Aged; Biomarkers; Carnitine; Coronary Angiography; Coronary Artery Disease; Coronary Stenosis; Cross-Sectional Studies; Cultured Milk Products; Female; Germany; Humans; Male; Middle Aged; Predictive Value of Tests; Prevalence; Protective Factors; Risk Factors; Severity of Illness Index | 2020 |
A targeted metabolomic profiling of plasma acylcarnitines in nonalcoholic fatty liver disease.
Topics: Adult; Biomarkers; Carnitine; Case-Control Studies; Chromatography, High Pressure Liquid; Female; Humans; Male; Metabolome; Metabolomics; Middle Aged; Non-alcoholic Fatty Liver Disease; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry | 2020 |
Metabolomic signature of the seminal plasma in men with severe oligoasthenospermia.
Topics: Adult; Amines; Amino Acids; Carnitine; Fatty Acids, Unsaturated; Humans; Male; Metabolome; Metabolomics; Oligospermia; Phosphatidylcholines; Prospective Studies; Semen; Semen Analysis; Sperm Motility; Spermatozoa; Sphingomyelins | 2020 |
Perinatal free carnitine and short chain acylcarnitine blood concentrations in 12,000 full-term breastfed newborns in relation to their birth weight.
Topics: Biomarkers; Birth Weight; Breast Feeding; Carnitine; Chromatography, Liquid; Fatty Acids; Female; Humans; Infant; Infant, Newborn; Male; Neonatal Screening; Reference Values; Tandem Mass Spectrometry | 2020 |
Quantitative Metabolomics Reveals Heart Failure With Midrange Ejection Fraction as a Distinct Phenotype of Heart Failure.
Topics: Amino Acids; Analysis of Variance; Biomarkers; Carnitine; China; Female; Heart Failure; Humans; Kaplan-Meier Estimate; Male; Metabolome; Metabolomics; Middle Aged; Patient Acuity; Phenotype; Predictive Value of Tests; Prognosis; ROC Curve; Stroke Volume | 2021 |
Kinetics of Serum Carnitine Fractions in Patients with Chronic Kidney Disease Not on Dialysis.
Topics: Adult; Aged; Amino Acids; Carnitine; Female; Glomerular Filtration Rate; Humans; Kidney; Kidney Failure, Chronic; Kinetics; Male; Middle Aged; Renal Insufficiency, Chronic; Urea; Uric Acid | 2021 |
Decreases in Circulating Concentrations of Short-Chain Acylcarnitines are Associated with Systolic Function Improvement After Decompensated Heart Failure.
Topics: Aged; Carnitine; Case-Control Studies; Esters; Fatty Acids; Female; Heart Failure; Humans; Male; Mass Spectrometry; Metabolomics; Middle Aged; Prognosis; Stroke Volume; Systole | 2020 |
Distinct lipid signatures are identified in the plasma of rats with chronic inflammation induced by estradiol benzoate and sex hormones.
Topics: Amino Acids; Animals; Biomarkers; Carnitine; Estradiol; Glycerophospholipids; Glycine; Gonadal Steroid Hormones; Humans; Inflammation; Lipids; Male; Metabolomics; Plasma; Prostatic Neoplasms; Prostatitis; Rats; Rats, Sprague-Dawley; Sphingomyelins | 2020 |
Untargeted lipidomics reveals specific lipid abnormalities in Sjögren's syndrome.
Topics: Biomarkers; Carnitine; Case-Control Studies; Chromatography, High Pressure Liquid; Discriminant Analysis; Female; Humans; Lipidomics; Male; Mass Spectrometry; Phosphatidylcholines; Sensitivity and Specificity; Sjogren's Syndrome; Triglycerides | 2021 |
Untargeted metabolomics yields insight into ALS disease mechanisms.
Topics: Aged; Amyotrophic Lateral Sclerosis; Benzoates; Carnitine; Case-Control Studies; Ceramides; Creatine; Discriminant Analysis; Fatty Acids; Fatty Acids, Unsaturated; Female; Humans; Least-Squares Analysis; Logistic Models; Machine Learning; Male; Metabolic Networks and Pathways; Metabolomics; Middle Aged | 2020 |
[Recommendations for acylcarnitine profile analysis].
Topics: Accreditation; Adult; Amniocentesis; Amniotic Fluid; Blood Chemical Analysis; Blood Specimen Collection; Carnitine; Child; Chromatography, Paper; Clinical Laboratory Services; Diagnostic Tests, Routine; Female; Humans; Infant, Newborn; Male; Metabolism, Inborn Errors; Neonatal Screening; Pre-Analytical Phase; Pregnancy; Prenatal Diagnosis; Urinalysis; Urine Specimen Collection | 2020 |
Proteinuria as a presenting sign of combined methylmalonic acidemia and homocysteinemia: case report.
Topics: Adolescent; Amino Acid Metabolism, Inborn Errors; Amino Acids; Base Sequence; Carnitine; Child, Preschool; DNA; Gas Chromatography-Mass Spectrometry; Homocysteine; Humans; Hyperhomocysteinemia; Male; Methylmalonic Acid; Proteinuria | 2020 |
Acyl-Carnitine plasma levels and their association with metabolic syndrome in individuals with schizophrenia.
Topics: Adult; Biomarkers; Carnitine; Case-Control Studies; Female; Humans; Male; Metabolic Syndrome; Plasma; Schizophrenia; Schizophrenic Psychology | 2020 |
Serum acylcarnitines and amino acids and risk of type 2 diabetes in a multiethnic Asian population.
Topics: Amino Acids; Carnitine; Diabetes Mellitus, Type 2; Female; Humans; Male; Prospective Studies; Risk Factors; Singapore | 2020 |
Laboratory analysis of acylcarnitines, 2020 update: a technical standard of the American College of Medical Genetics and Genomics (ACMG).
Topics: Carnitine; Genetics, Medical; Genomics; Humans; Infant, Newborn; Laboratories; United States | 2021 |
Testosterone replacement therapy in blood donors modulates erythrocyte metabolism and susceptibility to hemolysis in cold storage.
Topics: Animals; Arginine; Blood Donors; Blood Preservation; Carnitine; Chromatography, High Pressure Liquid; Cohort Studies; Correlation of Data; Dopamine; Erucic Acids; Erythrocytes; Fatty Acids; Female; Glutathione; Hemolysis; Hormone Replacement Therapy; Humans; Male; Mass Spectrometry; Metabolic Networks and Pathways; Mice; Mice, Inbred Strains; Oxidation-Reduction; Pentose Phosphate Pathway; Purines; Testosterone; Tumor Protein, Translationally-Controlled 1 | 2021 |
Altered Acylcarnitine Metabolism Is Associated With an Increased Risk of Atrial Fibrillation.
Topics: Aged; Atrial Fibrillation; Carnitine; Cohort Studies; Female; Humans; Incidence; Male; Metabolomics; Middle Aged; Proportional Hazards Models; Risk Factors | 2020 |
Association of cardiac autonomic dysfunction with higher levels of plasma lipid metabolites in recent-onset type 2 diabetes.
Topics: Adult; Autonomic Nervous System Diseases; Carnitine; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Diabetic Neuropathies; Dyslipidemias; Fatty Acids, Nonesterified; Female; Glucose Clamp Technique; Heart Rate; Humans; Insulin Resistance; Lipid Metabolism; Lipidomics; Lysophosphatidylcholines; Male; Middle Aged; Obesity; Phosphatidylcholines; Sphingomyelins; Young Adult | 2021 |
Liraglutide treatment and acylcarnitine profiles in Egyptian obese insulin-resistant females.
Topics: Adult; Anti-Obesity Agents; Biomarkers; Blood Glucose; Carnitine; Case-Control Studies; Egypt; Female; Glycated Hemoglobin; Humans; Hypoglycemic Agents; Insulin Resistance; Liraglutide; Metabolomics; Middle Aged; Mitochondria; Obesity; Time Factors; Treatment Outcome; Weight Loss | 2021 |
Macrophages and acylcarnitines: New players in aspirin-exacerbated respiratory disease?
Topics: Aspirin; Asthma, Aspirin-Induced; Carnitine; Humans; Macrophages | 2021 |
Altered Serum Amino Acid and Acylcarnitine Profiles in Hyperinsulinemic Hypoglycemia and Ketotic Hypoglycemia.
Topics: Amino Acids; Biomarkers; Carnitine; Case-Control Studies; Child, Preschool; Congenital Hyperinsulinism; Female; Follow-Up Studies; Humans; Hypoglycemia; Infant; Ketosis; Male; Prognosis; Retrospective Studies | 2020 |
Mitochondrial dysfunction in inflammatory bowel disease alters intestinal epithelial metabolism of hepatic acylcarnitines.
Topics: Animals; Caco-2 Cells; Carnitine; Citrobacter rodentium; Enterobacteriaceae Infections; Female; Humans; Inflammatory Bowel Diseases; Intestinal Mucosa; Liver; Male; Mice; Mice, Inbred BALB C; Mitochondria | 2021 |
Loss of Muscle Carnitine Palmitoyltransferase 2 Prevents Diet-Induced Obesity and Insulin Resistance despite Long-Chain Acylcarnitine Accumulation.
Topics: Animals; Carnitine; Carnitine O-Palmitoyltransferase; Female; Humans; Insulin Resistance; Mice; Obesity | 2020 |
Plasma metabolomics supports the use of long-duration cardiac arrest rodent model to study human disease by demonstrating similar metabolic alterations.
Topics: Animals; Biomarkers; Cardiopulmonary Resuscitation; Carnitine; Disease Models, Animal; Fatty Acids; Heart Arrest; Humans; Kynurenic Acid; Male; Metabolomics; Phospholipids; Rats; Rats, Sprague-Dawley; Severity of Illness Index; Tryptophan | 2020 |
Novel metabolomics markers are associated with pre-clinical decline in hand grip strength in community-dwelling older adults.
Topics: Aged; Aging; Asymptomatic Diseases; Biomarkers; Carnitine; Energy Metabolism; Fatty Acids; Female; Frailty; Geriatric Assessment; Hand Strength; Humans; Independent Living; Longitudinal Studies; Male; Metabolomics; Mitochondria, Muscle; Prognosis; Sarcopenia | 2021 |
Enhancing confidence of metabolite annotation in Capillary Electrophoresis-Mass Spectrometry untargeted metabolomics with relative migration time and in-source fragmentation.
Topics: Animals; Carnitine; Electrophoresis, Capillary; Humans; Metabolomics; Rabbits; Rats; Tandem Mass Spectrometry; Time Factors | 2021 |
Carnitine Serum Levels in Frail Older Subjects.
Topics: Aged; Aged, 80 and over; Carnitine; Cross-Sectional Studies; Female; Frail Elderly; Frailty; Geriatric Assessment; Humans; Male; Nutritional Status | 2020 |
[Newborn Screening Program in the Community of Madrid: evaluation of positive cases.]
Topics: Acyl-CoA Dehydrogenase; Amino Acid Metabolism, Inborn Errors; Carnitine; Cities; Female; Humans; Infant, Newborn; Lipid Metabolism, Inborn Errors; Male; Neonatal Screening; Predictive Value of Tests; Prevalence; Spain; Tandem Mass Spectrometry | 2020 |
The Acylcarnitine Profile in Dried Blood Spots is Affected by Hematocrit: A Study of Newborn Screening Samples in Very-Low-Birth-Weight Infants.
Topics: Carnitine; Hematocrit; Humans; Infant; Infant, Newborn; Infant, Very Low Birth Weight; Neonatal Screening | 2022 |
An Examination of Serum Acylcarnitine and Amino Acid Profiles at Different Time Point of Ketogenic Diet Therapy and Their Association of Ketogenic Diet Effectiveness.
Topics: 3-Hydroxybutyric Acid; Adolescent; Amino Acids; Carnitine; Case-Control Studies; Child; Child, Preschool; Diet, Ketogenic; Drug Resistant Epilepsy; Female; Humans; Infant; Male; Prospective Studies; Tandem Mass Spectrometry; Treatment Outcome; Young Adult | 2020 |
Walnut Consumption, Plasma Metabolomics, and Risk of Type 2 Diabetes and Cardiovascular Disease.
Topics: Amino Acids; Biomarkers; Cardiovascular Diseases; Carnitine; Diabetes Mellitus, Type 2; Humans; Juglans; Lipids; Metabolomics; Nuts; Purines; Risk Factors | 2021 |
Hyperammonemia, Lactic Acidosis, and Arrhythmia in a Newborn.
Topics: Acidosis, Lactic; Arrhythmias, Cardiac; Carnitine; Female; Humans; Hyperammonemia; Infant, Newborn; Lipid Metabolism, Inborn Errors; Membrane Transport Proteins; Mutation | 2021 |
Exercise modifies glutamate and other metabolic biomarkers in cerebrospinal fluid from Gulf War Illness and Myalgic encephalomyelitis / Chronic Fatigue Syndrome.
Topics: Adult; Biomarkers; Carnitine; Case-Control Studies; Exercise Test; Fatigue Syndrome, Chronic; Female; Glutamic Acid; Humans; Male; Metabolomics; Middle Aged; Persian Gulf Syndrome; Phospholipases | 2021 |
Untargeted Metabolomics Reveals Elevated L-Carnitine Metabolism in Pig and Rat Colon Tissue Following Red Versus White Meat Intake.
Topics: Animals; Carnitine; Chickens; Colon; Diet, Western; HT29 Cells; Humans; Lipid Metabolism; Male; Metabolomics; Rats, Sprague-Dawley; Red Meat; Swine | 2021 |
Gene spectrum and clinical traits of 10 patients with primary carnitine deficiency.
Topics: Adult; Cardiomyopathies; Carnitine; Female; Gene Frequency; Humans; Hyperammonemia; Infant; Male; Muscular Diseases; Mutation; Phenotype; Solute Carrier Family 22 Member 5 | 2021 |
Partial Biotinidase Deficiency Revealed Imbalances in Acylcarnitines Profile at Tandem Mass Spectrometry Newborn Screening.
Topics: Biotinidase; Biotinidase Deficiency; Carnitine; Female; Humans; Infant; Infant, Newborn; Neonatal Screening; Tandem Mass Spectrometry | 2021 |
Circulating metabolites and lipids are associated with glycaemic measures in South Asians.
Topics: Adult; Aged; Aged, 80 and over; Asia, Western; Betaine; Blood Glucose; Carnitine; Chromatography, Liquid; Cohort Studies; Diabetes Mellitus; Diglycerides; Female; Glycated Hemoglobin; Humans; Linear Models; Lipidomics; Logistic Models; Male; Mass Spectrometry; Metabolomics; Middle Aged; Proline; Sphingomyelins; Triglycerides; United States | 2021 |
Sex Differences in Insulin Sensitivity are Related to Muscle Tissue Acylcarnitine But Not Subcellular Lipid Distribution.
Topics: Adult; Carnitine; Citric Acid Cycle; Cohort Studies; Female; Glucose Clamp Technique; Glucose Tolerance Test; Humans; Insulin; Insulin Resistance; Lipid Metabolism; Male; Mitochondria, Muscle; Muscle, Skeletal; Obesity; Oxidation-Reduction; Sex Characteristics; Sphingolipids; Subcellular Fractions | 2021 |
Novel Strategy for Mining and Identification of Acylcarnitines Using Data-Independent-Acquisition-Based Retention Time Prediction Modeling and Pseudo-Characteristic Fragmentation Ion Matching.
Topics: Carnitine; Chromatography, Liquid; Linear Models; Mass Spectrometry | 2021 |
Rhodiola crenulata extract decreases fatty acid oxidation and autophagy to ameliorate pulmonary arterial hypertension by targeting inhibiton of acylcarnitine in rats.
Topics: Animals; Autophagy; Carnitine; Fatty Acids; Lipid Metabolism; Plant Extracts; Pulmonary Arterial Hypertension; Rats; Rhodiola | 2021 |
Alterations in acylcarnitines, amines, and lipids inform about the mechanism of action of citalopram/escitalopram in major depression.
Topics: Amines; Antidepressive Agents; Carnitine; Citalopram; Depression; Depressive Disorder, Major; Humans; Lipids; Selective Serotonin Reuptake Inhibitors | 2021 |
Serum carnitine concentration and the acyl to free carnitine ratio in nondialysis chronic kidney disease and hemodialysis patients.
Topics: Aged; Carnitine; Female; Humans; Male; Middle Aged; Renal Dialysis; Renal Insufficiency, Chronic | 2022 |
Plasma Targeted Metabolomics Analysis for Amino Acids and Acylcarnitines in Patients with Prediabetes, Type 2 Diabetes Mellitus, and Diabetic Vascular Complications.
Topics: Amino Acids; Carnitine; Diabetes Mellitus, Type 2; Diabetic Angiopathies; Humans; Metabolomics; Prediabetic State | 2021 |
Cell metabolomics analyses revealed a role of altered fatty acid oxidation in neurotoxicity pattern difference between nab-paclitaxel and solvent-based paclitaxel.
Topics: Acyl-CoA Dehydrogenase; Albumin-Bound Paclitaxel; Albumins; Carnitine; Cell Differentiation; Cell Line, Tumor; Cell Survival; Fatty Acids; Humans; Metabolomics; Neurotoxins; Oxidation-Reduction; Paclitaxel; Solvents | 2021 |
Changes in the metabolic profile of human male postmortem frontal cortex and cerebrospinal fluid samples associated with heavy alcohol use.
Topics: Adult; Aged; Alcoholism; Autopsy; Body Mass Index; Carnitine; Cerebrospinal Fluid; Chromatography, Liquid; Frontal Lobe; Humans; Male; Mass Spectrometry; Middle Aged; Neurotransmitter Agents; Patient Acuity | 2021 |
Perilipin 2 downregulation in β cells impairs insulin secretion under nutritional stress and damages mitochondria.
Topics: Animals; Carnitine; Diet, High-Fat; Down-Regulation; Glucose; Humans; In Vitro Techniques; Insulin Secretion; Insulin-Secreting Cells; Islets of Langerhans; Lipid Droplets; Mice; Mice, Knockout; Mitochondria; Oleic Acid; Oxidative Phosphorylation; Oxidative Stress; Oxygen Consumption; Perilipin-2; Rats; Stress, Physiological | 2021 |
Newborn screening and molecular features of patients with multiple acyl-CoA dehydrogenase deficiency in Quanzhou, China.
Topics: Acyl-CoA Dehydrogenase; Asian People; Carnitine; China; Female; Follow-Up Studies; Genetic Testing; Genotype; Humans; Infant, Newborn; Male; Multiple Acyl Coenzyme A Dehydrogenase Deficiency; Mutation; Neonatal Screening; Prognosis | 2021 |
SLC22A14 is a mitochondrial riboflavin transporter required for sperm oxidative phosphorylation and male fertility.
Topics: Animals; Carnitine; Citric Acid Cycle; Diet; Fatty Acids; Female; Fertility; Fertilization in Vitro; Gene Expression; Humans; Infertility, Male; Male; Metabolome; Mice; Mice, Inbred C57BL; Mice, Knockout; Mitochondria; Mitochondrial Membranes; Models, Molecular; Organic Cation Transport Proteins; Oxidative Phosphorylation; Riboflavin; Sperm Motility; Spermatozoa | 2021 |
Post-Mortem Metabolomics: A Novel Approach in Clinical Biomarker Discovery and a Potential Tool in Death Investigations.
Topics: Amino Acids; Biomarkers; Carnitine; Chromatography, High Pressure Liquid; Discriminant Analysis; Humans; Lipids; Metabolomics; Niacinamide; Nucleotides; Principal Component Analysis; Steroids | 2021 |
Association of plasma acylcarnitines with insulin sensitivity, insulin secretion, and prediabetes in a biracial cohort.
Topics: Adult; Blood Glucose; Carnitine; Cross-Sectional Studies; Glucose Intolerance; Humans; Insulin Resistance; Insulin Secretion; Insulins; Male; Middle Aged; Prediabetic State | 2021 |
An Unusual Peak in a Common Clinical Presentation.
Topics: Carnitine; Diagnosis, Differential; Female; Glutamate Formimidoyltransferase; Humans; Infant; Leukomalacia, Periventricular; Metabolism, Inborn Errors | 2021 |
Increasing fatty acid oxidation elicits a sex-dependent response in failing mouse hearts.
Topics: Acetyl-CoA Carboxylase; Animals; Carnitine; Disease Models, Animal; Energy Metabolism; Fatty Acids; Female; Gene Deletion; Heart Failure; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Myocardium; Oxidation-Reduction; PPAR alpha; Sex Factors; Signal Transduction; Tamoxifen | 2021 |
Metabolomics Profiling of Patients With A-β+ Ketosis-Prone Diabetes During Diabetic Ketoacidosis.
Topics: Adult; Amino Acids, Branched-Chain; Autoantibodies; Carnitine; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Diabetic Ketoacidosis; Female; Humans; Male; Metabolome; Metabolomics; Middle Aged | 2021 |
Topics: Adrenergic beta-2 Receptor Agonists; Animals; Carnitine; Fatty Liver; Formoterol Fumarate; Gene Expression; Hepatic Stellate Cells; Lipid Metabolism; Lipogenesis; Liver; Male; Mice; Mice, Inbred C57BL; Non-alcoholic Fatty Liver Disease; Phosphatidate Phosphatase; Receptors, Adrenergic, beta-2; Triglycerides | 2021 |
Long-chain acylcarnitine 18:1 acutely increases human atrial myocardial contractility and arrhythmia susceptibility.
Topics: Aged; Aged, 80 and over; Calcium Signaling; Carnitine; Female; Heart Atria; Humans; Male; Middle Aged; Myocardial Contraction; Myocytes, Cardiac | 2021 |
Exacerbation of cardiovascular ageing by diabetes mellitus and its associations with acyl-carnitines.
Topics: Aged; Aging; Cardiovascular System; Carnitine; Diabetes Mellitus; Female; Humans; Male; Middle Aged | 2021 |
Quantitation and evaluation of perinatal medium-chain and long-chain acylcarnitine blood concentrations in 12,000 full-term breastfed newborns.
Topics: Biomarkers; Birth Weight; Breast Feeding; Carnitine; Female; Follow-Up Studies; Humans; Infant, Newborn; Lipid Metabolism, Inborn Errors; Male; Neonatal Screening; Prognosis | 2021 |
Long-Chain Acylcarnitines Decrease the Phosphorylation of the Insulin Receptor at Tyr1151 Through a PTP1B-Dependent Mechanism.
Topics: Animals; Carnitine; CHO Cells; Cricetulus; Cyclic AMP-Dependent Protein Kinases; Insulin; Insulin Resistance; Models, Biological; Phosphorylation; Protein Phosphatase 2; Protein Tyrosine Phosphatase, Non-Receptor Type 1; Proto-Oncogene Proteins c-akt; Receptor, Insulin; Tyrosine | 2021 |
Longitudinal associations of physical activity with plasma metabolites among colorectal cancer survivors up to 2 years after treatment.
Topics: Aged; Arginine; Cancer Survivors; Carnitine; Citrulline; Colorectal Neoplasms; Exercise; Female; Histidine; Humans; Longitudinal Studies; Lysophosphatidylcholines; Male; Metabolome; Middle Aged; Quality of Life; Self Report; Sphingomyelins; Tandem Mass Spectrometry | 2021 |
The metabolic landscape of decidua in recurrent pregnancy loss using a global metabolomics approach.
Topics: Abortion, Habitual; Adult; Carnitine; Case-Control Studies; Decidua; Female; Glycerophospholipids; Group II Phospholipases A2; Humans; Lipidomics; Metabolome; Pregnancy; Sphingolipids; Transferases (Other Substituted Phosphate Groups) | 2021 |
Increased plasma and milk short-chain acylcarnitine concentrations reflect systemic LPS response in mid-lactation dairy cows.
Topics: Animals; Carnitine; Cattle; Diet; Dietary Supplements; Energy Metabolism; Fatty Acids; Lactation; Lipopolysaccharides; Metabolomics; Milk | 2021 |
Circulating long chain acylcarnitines and outcomes in diabetic heart failure: an HF-ACTION clinical trial substudy.
Topics: Aged; Biomarkers; Carnitine; Clinical Trials as Topic; Diabetic Cardiomyopathies; Exercise Tolerance; Female; Health Status; Heart Failure; Hospitalization; Humans; Male; Metabolome; Metabolomics; Middle Aged; Prognosis; Risk Assessment; Risk Factors; Tandem Mass Spectrometry; Time Factors | 2021 |
A longitudinal study of plasma acylcarnitines throughout pregnancy and associations with risk of gestational diabetes mellitus.
Topics: Adult; Biomarkers; Carnitine; Case-Control Studies; Diabetes, Gestational; Female; Gestational Age; Humans; Longitudinal Studies; Pregnancy; Pregnancy Trimesters; Prospective Studies; Risk Factors | 2021 |
Acylcarnitine profile in Alaskan sled dogs during submaximal multiday exercise points out metabolic flexibility and liver role in energy metabolism.
Topics: Animals; Carnitine; Dogs; Energy Metabolism; Gluconeogenesis; Glycogen; Liver; Muscle, Skeletal; Physical Conditioning, Animal | 2021 |
Association Between Graft Function and Urine CXCL10 and Acylcarnitines Levels in Kidney Transplant Recipients.
Topics: Carnitine; Chemokine CXCL10; Creatinine; Cystatin C; Graft Rejection; Humans; Kidney; Kidney Transplantation; Transplant Recipients | 2022 |
The effect of combined oral contraceptives containing drospirenone and ethinylestradiol on serum levels of amino acids and acylcarnitines.
Topics: Amino Acids; Androstenes; Carnitine; Contraceptives, Oral, Combined; Ethinyl Estradiol; Female; Humans | 2021 |
Nutrient-related metabolite profiles explain differences in body composition and size in Nile tilapia (Oreochromis niloticus) from different lakes.
Topics: Amino Acids; Animals; Body Composition; Body Size; Carnitine; Chemical Phenomena; Cichlids; Fish Proteins; Food; Geography; Lakes; Lipids; Metabolomics | 2021 |
Diminished retinal complex lipid synthesis and impaired fatty acid β-oxidation associated with human diabetic retinopathy.
Topics: Adult; Aged; American Indian or Alaska Native; Arizona; Black or African American; Carnitine; Case-Control Studies; Ceramides; Diabetes Mellitus, Type 2; Diabetic Retinopathy; Diglycerides; Disease Progression; Esters; Female; Hispanic or Latino; Humans; Lipidomics; Male; Mass Spectrometry; Middle Aged; Mitochondria; Phosphatidylcholines; Retina; Triglycerides; White People | 2021 |
Long-Chain Acyl-Carnitines Interfere with Mitochondrial ATP Production Leading to Cardiac Dysfunction in Zebrafish.
Topics: Adenosine Triphosphate; Animals; Carnitine; Disease Models, Animal; Fatty Acids; Heart; Heart Diseases; Humans; Mitochondria, Heart; Myocytes, Cardiac; Oxidation-Reduction; Zebrafish | 2021 |
Absolute Quantification of Acylcarnitines Using Integrated Tmt-PP Derivatization-Based LC-MS/MS and Quantitative Analysis of Multi-Components by a Single Marker Strategy.
Topics: Animals; Carnitine; Chromatography, Liquid; Metabolomics; Mice; Tandem Mass Spectrometry | 2021 |
Biological and Clinical Factors Contributing to the Metabolic Heterogeneity of Hospitalized Patients with and without COVID-19.
Topics: Acute Disease; Adult; Amino Acids; Body Mass Index; Carnitine; Cohort Studies; COVID-19; Fatty Acids; Female; Humans; Kynurenine; Machine Learning; Metabolomics; Middle Aged; Prognosis; Prospective Studies; SARS-CoV-2; Severity of Illness Index; Tryptophan | 2021 |
Impact of Newborn Screening and Early Dietary Management on Clinical Outcome of Patients with Long Chain 3-Hydroxyacyl-CoA Dehydrogenase Deficiency and Medium Chain Acyl-CoA Dehydrogenase Deficiency-A Retrospective Nationwide Study.
Topics: 3-Hydroxyacyl CoA Dehydrogenases; Acyl-CoA Dehydrogenase; Cardiomyopathies; Carnitine; Child; Child, Preschool; Czech Republic; Female; Humans; Incidence; Infant; Infant, Newborn; Lipid Metabolism, Inborn Errors; Male; Metabolism, Inborn Errors; Mitochondrial Myopathies; Mitochondrial Trifunctional Protein; Neonatal Screening; Nervous System Diseases; Outcome Assessment, Health Care; Retrospective Studies; Rhabdomyolysis; Severity of Illness Index | 2021 |
Longitudinal Plasma Metabolomics Profile in Pregnancy-A Study in an Ethnically Diverse U.S. Pregnancy Cohort.
Topics: Adolescent; Adult; Amino Acids; Body Mass Index; Carnitine; Fatty Acids; Female; Humans; Male; Metabolomics; Pregnancy; Pregnancy Trimesters; Prospective Studies; Racial Groups; United States; Young Adult | 2021 |
Untargeted metabolomic analysis of urine samples for diagnosis of inherited metabolic disorders.
Topics: Amino Acids; Biomarkers; Carnitine; Child; Humans; Mass Spectrometry; Metabolic Diseases; Metabolomics; Nucleosides | 2021 |
Spatial metabolomics identifies localized chemical changes in heart tissue during chronic cardiac Chagas Disease.
Topics: Animals; Carnitine; Chagas Cardiomyopathy; Chronic Disease; Heart; Humans; Male; Metabolomics; Mice; Mice, Inbred C3H; Myocardium; Phosphorylcholine; Trypanosoma cruzi | 2021 |
Impaired beta-oxidation increases vulnerability to influenza A infection.
Topics: Amino Acids, Branched-Chain; Animals; Carnitine; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Influenza A virus; Mice; Orthomyxoviridae Infections; Oxidation-Reduction | 2021 |
Plasma acyl-carnitines, bilirubin, tyramine and tetrahydro-21-deoxycortisol in Parkinson's disease and essential tremor. A case control biomarker study.
Topics: Aged; Bilirubin; Biomarkers; Carnitine; Case-Control Studies; Cognition; Cortodoxone; Diagnosis, Differential; Essential Tremor; Female; Humans; Male; Middle Aged; Parkinson Disease; Tyramine | 2021 |
Very long chain acylcarnitines and lysophosphatidylcholines in screening of peroxisomal disease in children by tandem mass spectrometry.
Topics: Carnitine; Child; Dried Blood Spot Testing; Humans; Lysophosphatidylcholines; Tandem Mass Spectrometry | 2021 |
Medium & long-chain acylcarnitine's relation to lipid metabolism as potential predictors for diabetic cardiomyopathy: a metabolomic study.
Topics: Adult; Aminoimidazole Carboxamide; Animals; Biomarkers; Carnitine; Cell Line; Diabetes Mellitus, Type 2; Diabetic Cardiomyopathies; Female; Humans; Lipid Metabolism; Male; Mass Spectrometry; Middle Aged; Myoblasts, Cardiac; Myristic Acids; Rats; Retrospective Studies; Ribonucleosides; Risk Factors | 2021 |
Low cardiac content of long-chain acylcarnitines in TMLHE knockout mice prevents ischaemia-reperfusion-induced mitochondrial and cardiac damage.
Topics: Animals; Carnitine; Ischemia; Male; Mice; Mice, Knockout; Mitochondria, Heart; Reperfusion | 2021 |
Revealing potential lipid biomarkers in clear cell renal cell carcinoma using targeted quantitative lipidomics.
Topics: Adult; Biomarkers, Tumor; Carcinoma, Renal Cell; Carnitine; Cholesterol Esters; Chromatography, High Pressure Liquid; Diglycerides; Female; Humans; Kidney Neoplasms; Lipidomics; Lipids; Male; Middle Aged; Tandem Mass Spectrometry | 2021 |
Intrauterine growth restriction elevates circulating acylcarnitines and suppresses fatty acid metabolism genes in the fetal sheep heart.
Topics: Animals; Carnitine; Fatty Acids; Female; Fetal Growth Retardation; Fetal Heart; Placenta; Pregnancy; Sheep | 2022 |
Plasma Metabolomics of Intermediate and Neovascular Age-Related Macular Degeneration Patients.
Topics: Aged; Carnitine; Case-Control Studies; Discriminant Analysis; Female; Humans; Least-Squares Analysis; Linear Models; Lipids; Macular Degeneration; Male; Metabolic Networks and Pathways; Metabolome; Metabolomics; Middle Aged; Neovascularization, Pathologic | 2021 |
Heterogenous Clinical Landscape in a Consanguineous Malonic Aciduria Family.
Topics: Carboxy-Lyases; Carnitine; Child, Preschool; Consanguinity; Homozygote; Humans; Male; Malonates; Malonyl Coenzyme A; Metabolism, Inborn Errors; Methylmalonic Acid; Pedigree; Point Mutation | 2021 |
A clinically validated method to separate and quantify underivatized acylcarnitines and carnitine metabolic intermediates using mixed-mode chromatography with tandem mass spectrometry.
Topics: Carnitine; Chromatography, Liquid; Humans; Isomerism; Tandem Mass Spectrometry | 2022 |
Differential and Synergistic Effects of Low Birth Weight and Western Diet on Skeletal Muscle Vasculature, Mitochondrial Lipid Metabolism and Insulin Signaling in Male Guinea Pigs.
Topics: Animal Nutritional Physiological Phenomena; Animals; Animals, Newborn; Birth Weight; Blood Glucose; Carnitine; Diet, Western; Disease Models, Animal; Female; Fetal Growth Retardation; Guinea Pigs; Insulin; Lipid Metabolism; Male; Mitochondria; Muscle, Skeletal; Placental Insufficiency; Pregnancy; Signal Transduction | 2021 |
Gene and metabolite expression dependence on body mass index in human myocardium.
Topics: Aged; Aged, 80 and over; Body Mass Index; Carnitine; Case-Control Studies; Cholesterol; Cohort Studies; Coronary Artery Bypass; Coronary Artery Disease; Female; Gene Expression Profiling; Humans; Immunity, Innate; Ketoglutaric Acids; Lipid Metabolism; Male; Metabolome; Middle Aged; Muscle Contraction; Myocardium; Obesity; Risk Factors; RNA, Messenger; Survival Analysis; Time Factors; Transcriptome | 2022 |
A HILIC-MS/MS method development and validation for the quantitation of 13 acylcarnitines in human serum.
Topics: Cardiovascular Diseases; Carnitine; Humans; Tandem Mass Spectrometry | 2022 |
Correlation between Acylcarnitine and Peripheral Neuropathy in Type 2 Diabetes Mellitus.
Topics: Adult; Aged; Body Mass Index; Carnitine; China; Cross-Sectional Studies; Diabetes Mellitus, Type 2; Female; Humans; Male; Middle Aged; Peripheral Nervous System Diseases; Risk Factors | 2022 |
Plasma acylcarnitine, risk for heart failure or atrial fibrillation, and effects of the Mediterranean diet or obesity.
Topics: Atrial Fibrillation; Carnitine; Diet, Mediterranean; Heart Failure; Humans; Obesity | 2022 |
Integrative metabolomic profiling reveals aberrations in myometrium associated with adenomyosis: a pilot study.
Topics: Adenomyosis; Adult; Amino Acids; Carbohydrate Metabolism; Carnitine; Chromatography, High Pressure Liquid; Female; Gas Chromatography-Mass Spectrometry; Humans; Lipid Metabolism; Mass Spectrometry; Metabolome; Metabolomics; Middle Aged; Myometrium; Nucleotides; Pilot Projects; Premenopause | 2022 |
Altered Serum Acylcarnitines Profile after a Prolonged Stay in Intensive Care.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Carnitine; Chromatography, Liquid; Critical Care; Female; Humans; Male; Middle Aged; Tandem Mass Spectrometry; Young Adult | 2022 |
Correlation of Serum Acylcarnitines with Clinical Presentation and Severity of Coronary Artery Disease.
Topics: Biomarkers; Carnitine; Coronary Artery Disease; Humans; Prospective Studies; ST Elevation Myocardial Infarction; Stroke Volume; Tandem Mass Spectrometry; Ventricular Function, Left | 2022 |
Specific lysophosphatidylcholine and acylcarnitine related to sarcopenia and its components in older men.
Topics: Aged; Amino Acids; Carnitine; Cross-Sectional Studies; Female; Hand Strength; Humans; Lysophosphatidylcholines; Male; Muscle, Skeletal; Sarcopenia | 2022 |
Relationship Between Acylcarnitine and the Risk of Retinopathy in Type 2 Diabetes Mellitus.
Topics: Biomarkers; Carnitine; Diabetes Mellitus, Type 2; Diabetic Retinopathy; Humans; ROC Curve | 2022 |
NMR Characterization of Long-Chain Fatty Acylcarnitine Binding to the Mitochondrial Carnitine/Acylcarnitine Carrier.
Topics: Carnitine; Carnitine Acyltransferases; Magnetic Resonance Spectroscopy; Mitochondria | 2022 |
Targeted metabolomics analysis of amino acids and acylcarnitines as risk markers for diabetes by LC-MS/MS technique.
Topics: Amino Acids; Carnitine; Chromatography, Liquid; Diabetes Mellitus; Female; Humans; Male; Metabolomics; Tandem Mass Spectrometry | 2022 |
Acylcarnitines and Genetic Variation in Fat Oxidation Genes in HIV-infected, Antiretroviral-treated Children With and Without Myopathy.
Topics: Anti-HIV Agents; Anti-Retroviral Agents; Carnitine; Child; Genetic Variation; HIV Infections; Humans; Muscular Diseases; Oxidation-Reduction; Reverse Transcriptase Inhibitors; Solute Carrier Family 22 Member 5 | 2022 |
Determinants of blood acylcarnitine concentrations in healthy individuals of the European Prospective Investigation into Cancer and Nutrition.
Topics: Carnitine; Diabetes Mellitus, Type 2; Fatty Acids; Humans; Neoplasms; Prospective Studies | 2022 |
Inhibition of the carnitine acylcarnitine carrier by carbon monoxide reveals a novel mechanism of action with non-metal-containing proteins.
Topics: Carbon Monoxide; Carnitine; Heme; Membrane Transport Proteins; Mitochondria; Organometallic Compounds | 2022 |
Low carnitine palmitoyltransferase 1 activity is a risk factor for narcolepsy type 1 and other hypersomnia.
Topics: Carnitine; Carnitine Acyltransferases; Carnitine O-Palmitoyltransferase; Disorders of Excessive Somnolence; Fatty Acids; Humans; Narcolepsy; Risk Factors | 2022 |
Combining data acquisition modes in liquid-chromatography-tandem mass spectrometry for comprehensive determination of acylcarnitines in human serum.
Topics: Carnitine; Chromatography, Liquid; Humans; Metabolomics; Tandem Mass Spectrometry | 2022 |
Circulating amino acids and acylcarnitines correlated with different CAC score ranges in diabetic postmenopausal women using LC-MS/MS based metabolomics approach.
Topics: Amino Acids; Cardiovascular Diseases; Carnitine; Chromatography, Liquid; Cross-Sectional Studies; Diabetes Mellitus; Female; Humans; Postmenopause; Tandem Mass Spectrometry | 2022 |
Effects of propofol and dexmedetomidine on carnitine metabolism in normal human bronchial epithelial cells.
Topics: Carnitine; Dexmedetomidine; Epithelial Cells; Humans; Propofol | 2023 |
Effects of dietary branched-chain amino acid supplementation on serum and milk metabolome profiles in dairy cows during early lactation.
Topics: Amino Acids, Branched-Chain; Animals; Antioxidants; Carnitine; Cattle; Choline; Diet; Dietary Supplements; Fatty Acids; Female; Glucose; Glutathione; Humans; Insulins; Lactation; Lipids; Metabolome; Milk; Nitrogen; Phosphorylcholine; Urea | 2022 |
Evaluating the association between amino acid and acylcarnitine profiles and different levels of coronary artery disease risk in postmenopausal women using targeted metabolomics technique.
Topics: Amino Acids; Biomarkers; Carnitine; Coronary Angiography; Coronary Artery Disease; Cross-Sectional Studies; Female; Humans; Phenylalanine; Postmenopause; Risk Factors; Vascular Calcification | 2022 |
Tandem Mass Analysis of Amino Acids and Acylcarnitine Profiles in Neonates with Congenital Hypothyroidism.
Topics: Amino Acids; Carnitine; Case-Control Studies; Child; Congenital Hypothyroidism; Female; Humans; Infant, Newborn; Male | 2023 |
Long time stability of 35 small endogenous biomolecules in dried urine spotted on various surfaces and environmental conditions.
Topics: Amino Acids; Body Fluids; Carnitine; Specimen Handling | 2022 |
Melatonin Regulates the Daily Levels of Plasma Amino Acids, Acylcarnitines, Biogenic Amines, Sphingomyelins, and Hexoses in a Xenograft Model of Triple Negative Breast Cancer.
Topics: Amino Acids; Animals; Biogenic Amines; Carnitine; Heterografts; Hexoses; Humans; Melatonin; Mice; Sphingomyelins; Triple Negative Breast Neoplasms | 2022 |
Identifying a metabolomics profile associated with masked hypertension in two independent cohorts: Data from the African-PREDICT and SABPA studies.
Topics: Amino Acids; Carnitine; Humans; Isoleucine; Leucine; Masked Hypertension; Metabolomics; Methionine; Phenylalanine; Valine | 2022 |
Dynamics of acylcarnitines, hypoglycin A, méthylènecyclopropylglycine and their metabolites in a Kladruber stallion with atypical myopathy.
Topics: Acyl-CoA Dehydrogenases; Animals; Carnitine; Creatine Kinase; Cyclopropanes; Fatty Acids; Glycine; Horse Diseases; Horses; Hypoglycins; Male; Muscular Diseases | 2022 |
Proline/Glycine residues of the PG-levels guide conformational changes along the transport cycle in the mitochondrial carnitine/acylcarnitine carrier (SLC25A20).
Topics: Alanine; Carnitine; Carnitine Acyltransferases; Glycine; Proline | 2022 |
Tandem Mass Spectrometry for the Analysis of Plasma/Serum Acylcarnitines for the Diagnosis of Certain Organic Acidurias and Fatty Acid Oxidation Disorders.
Topics: Carnitine; Carnitine Acyltransferases; Fatty Acids; Humans; Lipid Metabolism, Inborn Errors; Tandem Mass Spectrometry | 2022 |
Quantitation of Butyrylcarnitine, Isobutyrylcarnitine, and Glutarylcarnitine in Urine Using Ultra-Performance Liquid Chromatography-Tandem Mass Spectrometry (UPLC-MS/MS).
Topics: Carnitine; Chromatography, High Pressure Liquid; Chromatography, Liquid; Coenzyme A; Fatty Acids; Tandem Mass Spectrometry | 2022 |
Quantification of Free and Total Carnitine in Serum Using Liquid Chromatography Tandem Mass Spectrometry.
Topics: Carnitine; Chromatography, Liquid; Fatty Acids; Hydrochloric Acid; Tandem Mass Spectrometry | 2022 |
Targeted Metabolomics Revealed a Sex-Dependent Signature for Metabolic Syndrome in the Mexican Population.
Topics: Carnitine; Citrulline; Cohort Studies; Female; Glycine; Humans; Male; Metabolic Syndrome; Metabolomics | 2022 |
Cross-generational effects of maternal exposure to imazalil on anaerobic components and carnitine absorption associated with OCTN2 expression in mice.
Topics: Anaerobiosis; Animals; Caco-2 Cells; Carnitine; Cations; Female; Fungicides, Industrial; Humans; Imidazoles; Maternal Exposure; Mice; Mice, Inbred C57BL; Pregnancy; Solute Carrier Family 22 Member 5 | 2022 |
Early postnatal metabolic profile in neonates with critical CHDs.
Topics: Amino Acids; Carnitine; Case-Control Studies; Humans; Infant; Infant, Newborn; Metabolome | 2023 |
Targeted metabolomic profiles of serum amino acids and acylcarnitines related to gastric cancer.
Topics: Amino Acids; Arginine; Carnitine; Chromatography, Liquid; Gastritis; Gastritis, Atrophic; Humans; Stomach Neoplasms; Tandem Mass Spectrometry | 2022 |
Evaluation of plasma carnitine status in patients diagnosed with juvenile idiopathic arthritis.
Topics: Amino Acids; Arthritis, Juvenile; Carnitine; Child; Fasting; Humans; Tandem Mass Spectrometry | 2022 |
[Analysis of IVD gene variants in four children with isovalerate acidemia].
Topics: Acidosis; Carnitine; Child; Erythrocytes; High-Throughput Nucleotide Sequencing; Humans; Infant, Newborn | 2022 |
Long-Chain Acylcarnitines Induce Senescence of Invariant Natural Killer T Cells in Hepatocellular Carcinoma.
Topics: Antigens, CD1d; Carcinoma, Hepatocellular; Carnitine; Cellular Senescence; Galactosylceramides; Humans; Liver Neoplasms; Natural Killer T-Cells | 2023 |
Determination of Serum Differential Carnitine Ester Levels in HIV(+) Patients: A Cross-Sectional Study.
Topics: Carnitine; Chromatography, Liquid; Cross-Sectional Studies; Esters; HIV Infections; Humans; Tandem Mass Spectrometry | 2023 |
Sphingolipids and acylcarnitines are altered in placentas from women with gestational diabetes mellitus.
Topics: Carnitine; Ceramides; Diabetes, Gestational; Female; Humans; Placenta; Pregnancy; Sphingolipids | 2023 |
Metabolomics of a neonatal cohort from the Alliance for Maternal and Newborn Health Improvement biorepository: Effect of preanalytical variables on reference intervals.
Topics: Amines; Amino Acids; Carnitine; Female; Humans; Infant; Infant Health; Infant, Low Birth Weight; Infant, Newborn; Male | 2023 |
Free amino acid and acylcarnitine values in Ursus americanus Pallas 1780 (black bear) from Northeastern Mexico.
Topics: Amino Acids; Animals; Carnitine; Mexico; Ursidae | 2023 |
The association between acylcarnitine and amino acids profile and metabolic syndrome and its components in Iranian adults: Data from STEPs 2016.
Topics: Adult; Carnitine; Chromatography, Liquid; Citrulline; Cross-Sectional Studies; Diabetes Mellitus, Type 2; Humans; Iran; Metabolic Syndrome; Tandem Mass Spectrometry; Trypsin | 2023 |
Vitreous Fatty Amides and Acyl Carnitines Are Altered in Intermediate Age-Related Macular Degeneration.
Topics: Amides; Carnitine; Humans; Macular Degeneration; Niacinamide; Succinates; Vitreous Body | 2023 |
A case of Fukuyama-type congenital muscular dystrophy with acute carnitine deficiency triggered by fever, vomiting, and gastrointestinal bleeding.
Topics: Amino Acids; Carnitine; Fatty Acids; Gastrointestinal Hemorrhage; Humans; Male; Muscular Atrophy; Muscular Dystrophies; Vomiting | 2023 |
Heart-Type Fatty Acid Binding Protein Binds Long-Chain Acylcarnitines and Protects against Lipotoxicity.
Topics: Carnitine; Fatty Acid Binding Protein 3; Fatty Acid-Binding Proteins; Fatty Acids; Myocytes, Cardiac | 2023 |
Modulation of sleep by trafficking of lipids through the
Topics: Animals; Blood-Brain Barrier; Carnitine; Drosophila; Drosophila melanogaster; Drosophila Proteins; Lipids; Membrane Transport Proteins; Sleep | 2023 |
Predictive value of presepsin and acylcarnitines for severity and biliary drainage in acute cholangitis.
Topics: Acetylcarnitine; Biomarkers; C-Reactive Protein; Carnitine; Cholangitis; Drainage; Humans; Lipopolysaccharide Receptors; Peptide Fragments; Procalcitonin; Sepsis | 2023 |
Topics: Animals; Anterior Chamber; Carnitine; Swine | 2023 |
High-Throughput Analysis of Underivatized Amino Acids and Acylcarnitines in Infant Serum: A Micromethod Based on Stable Isotope Dilution Targeted HILIC-ESI-MS/MS.
Topics: Amino Acids; Carnitine; Child; Child, Preschool; Humans; Infant; Reproducibility of Results; Tandem Mass Spectrometry | 2023 |
Carnitine supplementation increases serum concentrations of free carnitine and total acylcarnitine in preterm neonates: A retrospective cohort study.
Topics: Amino Acids; Carnitine; Dietary Supplements; Humans; Infant; Infant, Newborn; Lipids; Retrospective Studies | 2023 |
Inhibition of the Mitochondrial Carnitine/Acylcarnitine Carrier by Itaconate through Irreversible Binding to Cysteine 136: Possible Pathophysiological Implications.
Topics: Carnitine; Cysteine; HeLa Cells; Humans; Membrane Transport Modulators; Membrane Transport Proteins; Mitochondria | 2023 |
Short and medium chain acylcarnitines as markers of outcome in diabetic and non-diabetic subjects with acute coronary syndromes.
Topics: Acetylcarnitine; Acute Coronary Syndrome; Carnitine; Clinical Studies as Topic; Cohort Studies; Diabetes Mellitus; Humans; Multicenter Studies as Topic; Prospective Studies | 2023 |
Metabolomic analysis of pig spleen reveals African swine fever virus infection increased acylcarnitine levels to facilitate viral replication.
Topics: African Swine Fever; African Swine Fever Virus; Animals; Carnitine; Fatty Acids; Metabolomics; Spleen; Swine; Virus Replication | 2023 |
Study of amphipathic metabolites in cardiac pathophysiology: Insights gained from long-chain acylcarnitines and calcium handling.
Topics: Calcium; Carnitine; Heart; Ryanodine Receptor Calcium Release Channel; Sarcoplasmic Reticulum | 2023 |
Altered markers of mitochondrial function in adults with autism spectrum disorder.
Topics: Adult; Autism Spectrum Disorder; Carnitine; Fatty Acids; Female; Humans; Lactic Acid; Male; Mitochondria; Pyruvic Acid | 2023 |
[A case of very long chain acyl-CoA dehydrogenase deficiency diagnosed due to a trigger of hyperemesis gravidarum during pregnancy].
Topics: Acyl-CoA Dehydrogenase, Long-Chain; Adult; Carnitine; Fatty Acids; Female; Humans; Hyperemesis Gravidarum; Infant, Newborn; Lipid Metabolism, Inborn Errors; Pregnancy; Rhabdomyolysis | 2023 |
Purification of S-adenosylmethionine: epsilon-N-L-lysine methyltransferase. The first enzyme in carnitine biosynthesis.
Topics: Amino Acids; Carnitine; Lysine; Methyltransferases; Molecular Weight; Neurospora crassa; S-Adenosylmethionine; Spectrophotometry; Spectrophotometry, Ultraviolet | 1977 |
Effects of long-term organ culture on neurotransmitter metabolism in the ganglia of Aplysia californica.
Topics: Acetylcholinesterase; Acetyltransferases; Action Potentials; Amino Acids; Animals; Carboxy-Lyases; Carnitine; Catechol O-Methyltransferase; Choline; Electrophysiology; Evoked Potentials; Ganglia; Glucosephosphate Dehydrogenase; Nerve Tissue Proteins; Neurotransmitter Agents; Organ Culture Techniques; S-Adenosylmethionine; Synaptic Transmission; Time Factors | 1974 |
Liquid cation exchange--a basis for sensitive radiometric assays for aromatic amino acid decarboxylases.
Topics: Aminobutyrates; Animals; Carbon Isotopes; Carboxy-Lyases; Carnitine; Choline; Dihydroxyphenylalanine; Dopa Decarboxylase; Dopamine; Drosophila melanogaster; Glutamates; Histamine; Histidine; Hydrogen-Ion Concentration; Ion Exchange; Methods; Norepinephrine; Organophosphorus Compounds; Phenethylamines; S-Adenosylmethionine; Serotonin; Tritium; Tyramine; Tyrosine; Tyrosine Decarboxylase | 1972 |