Compounds > carmustine

carmustine and o-(6)-methylguanine

carmustine has been researched along with o-(6)-methylguanine in 14 studies

Research

Studies (14)

TimeframeStudies, this research(%)All Research%
pre-19906 (42.86)18.7374
1990's6 (42.86)18.2507
2000's0 (0.00)29.6817
2010's2 (14.29)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Bigner, DD; Dolan, ME; Felker, GM; Friedman, HS; Moschel, RC; Pegg, AE; Rich, J; Schold, SC1
Arce, C; Berger, NA; Gerson, SL; Petzold, SJ; Willson, JK1
Elksne, SJ; Gorbacheva, LB; Kukushkina, GV; Miniker, TD; Preobrazhenskaya, MN1
Brent, TP; Gonzaga, PE; Harris, L; Margison, GP1
Barnes, DM; Erickson, LC; Fisher, RI; Futscher, BW; Micetich, KC1
Gerson, SL; Trey, JE2
Clyde, C; Dolan, ME; Erickson, LC; Hora, NK; Norbeck, L; Pegg, AE1
Barrows, LR; Borchers, AH; Paxton, MB1
Aida, T; Berger, MS; Bodell, WJ; Rosenblum, ML1
Berger, SJ; Donovan, C; Gerson, SL; Varnes, ME1
Gerson, SL; Liu, L; Markowitz, S1
Baumann, RP; Ishiguro, K; Penketh, PG; Sartorelli, AC; Shyam, K; Zhu, YL1
Blumenthal, DT; Moore, DF; Padula, GD; Rankin, C; Rushing, EJ; Schulman, SB; Sloan, AE; Spence, AM; Stelzer, KJ; Wade, ML1

Trials

1 trial(s) available for carmustine and o-(6)-methylguanine

ArticleYear
A Phase III study of radiation therapy (RT) and O⁶-benzylguanine + BCNU versus RT and BCNU alone and methylation status in newly diagnosed glioblastoma and gliosarcoma: Southwest Oncology Group (SWOG) study S0001.
    International journal of clinical oncology, 2015, Volume: 20, Issue:4

    Topics: Adult; Aged; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Carmustine; Combined Modality Therapy; DNA Methylation; Female; Glioblastoma; Gliosarcoma; Guanine; Humans; Male; Middle Aged; Radiotherapy; Young Adult

2015

Other Studies

13 other study(ies) available for carmustine and o-(6)-methylguanine

ArticleYear
Enhancement of nitrosourea activity in medulloblastoma and glioblastoma multiforme.
    Journal of the National Cancer Institute, 1992, Dec-16, Volume: 84, Issue:24

    Topics: Animals; Carmustine; Drug Resistance; Female; Glioblastoma; Guanine; Humans; Male; Medulloblastoma; Methyltransferases; Mice; Mice, Inbred BALB C; Neoplasm Transplantation; O(6)-Methylguanine-DNA Methyltransferase; Streptozocin; Transplantation, Heterologous

1992
Modulation of nitrosourea resistance in human colon cancer by O6-methylguanine.
    Biochemical pharmacology, 1992, Mar-03, Volume: 43, Issue:5

    Topics: Carmustine; Colonic Neoplasms; DNA Repair; Drug Resistance; Guanine; Humans; Methyltransferases; O(6)-Methylguanine-DNA Methyltransferase; Tumor Cells, Cultured

1992
O6-methylguanine as a modulator of antitumor activity of N-alkyl-N-nitrosoureas in vivo.
    Anti-cancer drugs, 1991, Volume: 2, Issue:2

    Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Carmustine; DNA Damage; DNA, Neoplasm; Drug Interactions; Drug Resistance; Guanine; Leukemia L1210; Methylnitrosourea; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Neoplasm Transplantation; Nucleic Acid Conformation; Time Factors

1991
Evidence that covalent complex formation between BCNU-treated oligonucleotides and E. coli alkyltransferases requires the O6-alkylguanine function.
    Nucleic acids research, 1990, Jul-11, Volume: 18, Issue:13

    Topics: Base Sequence; Carmustine; Electrophoresis, Polyacrylamide Gel; Escherichia coli; Guanine; Humans; Methyltransferases; Molecular Sequence Data; O(6)-Methylguanine-DNA Methyltransferase; Oligodeoxyribonucleotides

1990
Inhibition of a specific DNA repair system and nitrosourea cytotoxicity in resistant human cancer cells.
    Cancer communications, 1989, Volume: 1, Issue:1

    Topics: Carmustine; Cell Line; Cell Survival; DNA Probes; DNA Repair; DNA, Neoplasm; Drug Resistance; Guanine; Humans; Methyltransferases; O(6)-Methylguanine-DNA Methyltransferase; Restriction Mapping; Streptozocin; Tumor Cells, Cultured; Tumor Stem Cell Assay

1989
The role of O6-alkylguanine DNA alkyltransferase in limiting nitrosourea-induced sister chromatid exchanges in proliferating human lymphocytes.
    Cancer research, 1989, Apr-15, Volume: 49, Issue:8

    Topics: Carmustine; Cell Cycle; DNA Damage; DNA Repair; Guanine; Humans; Lymphocyte Activation; Lymphocytes; Methyltransferases; O(6)-Methylguanine-DNA Methyltransferase; Phytohemagglutinins; Sister Chromatid Exchange

1989
Expression of mammalian O6-alkylguanine-DNA alkyltransferase in a cell line sensitive to alkylating agents.
    Carcinogenesis, 1989, Volume: 10, Issue:9

    Topics: Alkylating Agents; Animals; Carmustine; Cell Division; Cell Line; Cricetinae; Cricetulus; Female; Guanine; Kinetics; Lomustine; Methylnitronitrosoguanidine; Methylnitrosourea; Methyltransferases; Mitoguazone; O(6)-Methylguanine-DNA Methyltransferase; Ovary; Transfection

1989
Transfectant CHO cells expressing O6-alkylguanine-DNA-alkyltransferase display increased resistance to DNA damage other than O6-guanine alkylation.
    Carcinogenesis, 1987, Volume: 8, Issue:12

    Topics: Alkylation; Animals; Carmustine; Cell Survival; Cricetinae; Cricetulus; Deoxyribonuclease BamHI; Deoxyribonuclease EcoRI; DNA Damage; DNA Restriction Enzymes; Guanine; Methylnitronitrosoguanidine; Methyltransferases; O(6)-Methylguanine-DNA Methyltransferase; Sulfuric Acid Esters; Thioguanine; Transfection; Ultraviolet Rays

1987
Modulation of nitrosourea resistance in myeloid leukemias.
    Blood, 1988, Volume: 71, Issue:5

    Topics: Carmustine; Cell Differentiation; Colony-Stimulating Factors; DNA Repair; Drug Resistance; Guanine; Hematopoietic Stem Cells; Humans; Leukemia, Myeloid; Leukemia, Myeloid, Acute; Methyltransferases; Neoplasm Proteins; Neoplastic Stem Cells; O(6)-Methylguanine-DNA Methyltransferase; Tumor Cells, Cultured

1988
Increased repair of O6-alkylguanine DNA adducts in glioma-derived human cells resistant to the cytotoxic and cytogenetic effects of 1,3-bis(2-chloroethyl)-1-nitrosourea.
    Carcinogenesis, 1986, Volume: 7, Issue:6

    Topics: Alkylation; Carmustine; Cell Line; Cell Survival; DNA; DNA Repair; Dose-Response Relationship, Drug; Drug Resistance; Glioma; Guanine; Humans; Methylnitrosourea; Methyltransferases; Nitroso Compounds; O(6)-Methylguanine-DNA Methyltransferase; Sister Chromatid Exchange; Tritium

1986
Combined depletion of O6-alkylguanine-DNA alkyltransferase and glutathione to modulate nitrosourea resistance in breast cancer.
    Biochemical pharmacology, 1994, Aug-03, Volume: 48, Issue:3

    Topics: Breast Neoplasms; Carmustine; Cell Line; Cell Survival; Drug Resistance; Ethylnitrosourea; Glutathione; Glutathione Transferase; Guanine; Humans; Methyltransferases; O(6)-Methylguanine-DNA Methyltransferase

1994
Mismatch repair mutations override alkyltransferase in conferring resistance to temozolomide but not to 1,3-bis(2-chloroethyl)nitrosourea.
    Cancer research, 1996, Dec-01, Volume: 56, Issue:23

    Topics: Antineoplastic Agents, Alkylating; Carmustine; Colonic Neoplasms; Dacarbazine; DNA Adducts; DNA Damage; DNA Repair; Drug Resistance, Neoplasm; Enzyme Inhibitors; Guanine; Humans; Methylation; Methyltransferases; Microsatellite Repeats; Mutation; O(6)-Methylguanine-DNA Methyltransferase; Phenotype; Temozolomide; Tumor Cells, Cultured; Tumor Stem Cell Assay

1996
Quantitative relationship between guanine O(6)-alkyl lesions produced by Onrigin™ and tumor resistance by O(6)-alkylguanine-DNA alkyltransferase.
    Biochemical pharmacology, 2010, Nov-01, Volume: 80, Issue:9

    Topics: Animals; Antineoplastic Agents; Carmustine; Cell Line, Tumor; Dacarbazine; DNA Damage; DNA Methylation; DNA Repair; Drug Resistance, Neoplasm; Guanine; Humans; Hydrazines; Mice; O(6)-Methylguanine-DNA Methyltransferase; Sulfonamides; Temozolomide

2010