Compounds > carmustine

carmustine and o(6)-benzylguanine

carmustine has been researched along with o(6)-benzylguanine in 107 studies

Research

Studies (107)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's48 (44.86)18.2507
2000's52 (48.60)29.6817
2010's7 (6.54)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Bellows, DS; Clarke, ID; Diamandis, P; Dirks, PB; Graham, J; Jamieson, LG; Ling, EK; Sacher, AG; Tyers, M; Ward, RJ; Wildenhain, J1
Bigner, DD; Dolan, ME; Felker, GM; Friedman, HS; Moschel, RC; Pegg, AE; Rich, J; Schold, SC1
Berger, MS; Bobola, MS; Ewers, TG; Muramoto, M; Silber, JR1
Dolan, ME; Mitchell, RB; Moschel, RC; Mummert, C; Pegg, AE1
Dolan, ME; Mitchell, RB; Moschel, RC1
Chae, MY; Dolan, ME; Moschel, RC; Pegg, AE; Swenn, K1
Gerson, SL; Willson, JK1
Magull-Seltenreich, A; Zeller, WJ2
Bigner, DD; Catino, JJ; Dolan, ME; Friedman, HS; Keir, S; Marcelli, S; Pegg, AE; Schold, SC1
Dolan, ME; Erickson, LC; Marathi, UK2
Dolan, ME; Flora, KP; Friedman, HS; Grever, MR; Moschel, RC; Pegg, AE; Vishnuvajjala, BR1
Berger, SJ; Donovan, C; Gerson, SL; Varnes, ME1
Dolan, ME; Felker, GM; Friedman, HS; Moschel, RC; Schold, C1
Deen, DF; Dolan, ME; Gonzalez, GG; Marton, LJ; Pegg, AE; Sarkar, A1
Dolan, ME; Grindey, GB; Moschel, RC; Pegg, AE1
Dolan, ME; Erickson, LC; Kroes, RA; Marathi, UK1
Gerson, SL; Gordon, NH; Norton, K; Willson, JK; Zborowska, E1
Biser, ND; Dolan, ME; English, HF; Moschel, RC; Pegg, AE1
Chen, JM; Ikenaga, M; Moschel, RC; Zhang, YP1
Ali-Osman, F; Friedman, HS; Srivenugopal, KS; Yuan, XH1
May, BL; Newlands, ES; Porteus, JK; Wedge, SR1
Loktionova, NA; Pegg, AE1
Gerson, SL; Lee, K; Liu, L; Wasan, E1
Newlands, ES; Wedge, SR1
Ali-Osman, F; Bigner, DD; Elion, GB; Friedman, HS; Keir, S; Marcelli, S; Moynihan, K1
Donovan, C; Dumenco, LL; Gerson, SL; Kastan, M; Phillips, W1
Kohda, K; Terashima, I1
Newlands, ES; Porteous, JK; Wedge, SR1
Allay, JA; Gerson, SL; Koç, ON; Lee, KM; Liu, L; Phillips, WP; Reese, JS1
Gerson, SL; Liu, L; Markowitz, S1
Archer, GE; Bigner, DD; Dolan, ME; Friedman, HS; Kurpad, SN; McLendon, RE; Moschel, RC; Pegg, AE1
Ashby, J; Chinnasamy, N; Dexter, TM; Fairbairn, LJ; Hickson, I; Margison, GP; Rafferty, JA; Tinwell, H1
Edgren, MR; Egyházi, S; Hansson, J; Kröckel, D; Mannervik, B; Ringborg, U1
Gerson, SL; Gordon, NH; Liu, L; Markowitz, SD; Phillips, WP; Willson, JK; Zaidi, NH; Zborowska, E1
Davis, BM; Gerson, SL; Koç, ON; Lee, K; Reese, JS; Schupp, JE1
Brent, TP; Harris, LC; Marathi, UK; Venable, CC1
Dolan, ME; Pegg, AE1
Brent, TP; Edwards, CC; Harris, LC; Houghton, PJ; Marathi, UK; Sorrentino, BP; Srivastava, DK; Vanin, EF1
Davis, BM; Gerson, SL; Liu, L; Reese, JS1
Bibby, MC; Margison, GP; McElhinney, RS; Rafferty, JA; Thompson, MJ1
Davis, BM; Gerson, SL; Koç, ON; Liu, L; Majczenko, KJ; Reese, JS1
Gerson, SL; Haaga, J; Hoppel, CL; Ingalls, ST; Liu, L; Majka, S; Pluda, JM; Spiro, TP; Willson, JK1
Crone, TM; Kanugula, S; Loktionova, NA; Pegg, AE; Xu-Welliver, M2
Gerson, SL; Phillips, WP1
Chinnasamy, D; Chinnasamy, N; Dexter, T; Fairbairn, L; Lashford, L; Margison, G; Rafferty, J; Thatcher, N1
Erickson, LC; Kreklau, EL; Kurpad, C; Williams, DA1
Davis, BM; Gerson, SL; Liu, L; Pegg, AE; Roth, JC; Xu-Welliver, M1
Kokkinakis, DM; Moschel, RC; Pegg, AE; Schold, SC1
Davis, BM; Gerson, SL; Koç, ON1
Bigner, DD; Dolan, ME; Friedman, HS; Keir, ST; Lawless, A; Moschel, RC; Pegg, AE1
Abdul-Rahman, S; Baker, TG; Bibby, MC; Margison, GP; Rafferty, JA; Thompson, MJ1
Gao, H; Lu, H; Wan, Y; Wu, D1
Erickson, LC; Kurpad, C; Maze, R; Pegg, A; Williams, DA1
Friedman, HS1
Bertucci, D; Dolan, ME; Ewesuedo, RB; Mani, S; Ratain, MJ; Schilsky, RL; Vogelzang, NJ; Wilson, LR1
Bailey, J; Chandra, S; Cooper, R; D'Souza, M; Pegg, AE; Ragg, S; Seshadri, R; Williams, DA; Xu-Welliver, M1
Ashley, DM; Bigner, DD; Cokgor, I; Colvin, OM; Dolan, ME; Ewesuedo, RB; Friedman, AH; Friedman, HS; Garcia-Turner, AM; Haglund, MM; Herndon, JE; Long, L; McLendon, RE; Moschel, RC; Pegg, AE; Pluda, J; Provenzale, JM; Quinn, JA; Rich, JN; Sampson, J; Stewart, ES; Tourt-Uhlig, S1
Cai, Y; Dolan, ME; Ludeman, SM; Pegg, AE; Wu, MH; Xu-Welliver, M1
Brem, H; Dolan, ME; Rhines, LD; Sampath, P; Tyler, BM; Weingart, J1
Goodtzova, K; Kanugula, S; Loktionova, NA; Moschel, RC; Pauly, GT; Pegg, AE1
Bocangel, DB; Kokkinakis, DM; Moschel, RC; Pegg, AE; Schold, SC1
Christians, FC; Davis, BM; Encell, LP; Friebert, SE; Gerson, SL; Liu, L; Loeb, LA; Zielske, SP1
Blokland, I; Boudewijn, A; Down, JD; Margison, GP; McGown, AT; Ploemacher, RE; Watson, AJ; Westerhof, GR; Wood, M1
Berger, NA; Berger, SJ; Dowlati, A; Gerson, SL; Haaga, J; Liu, L; Remick, SC; Spiro, TP; Willson, JK1
Gerson, SL; Koç, ON; Lee, K; Maitra, B1
Dolan, ME; Long, L1
Bigner, DD; Colvin, OM; Delaney, S; Dolan, ME; Friedman, AH; Friedman, HS; Gururangan, S; Haglund, MM; Herndon, JE; Kaplan, R; McLendon, RE; Moschel, RC; Pegg, AE; Pluda, J; Provenzale, JM; Quinn, JA; Reardon, DA; Rich, JN; Sampson, JH; Tourt-Uhlig, S1
Davis, BM; Gerson, SL; Liu, L; Schwartz, S1
Biser-Rohrbaugh, A; Bunton, TE; Carson, BS; Gabikian, P; Guarnieri, M; Tyler, BM; Weingart, J; Wu, QZ1
Bigner, DD; Colvin, OM; Dolan, ME; Friedman, HS; Houghton, PJ; Keir, S; Moschel, RC; Pegg, AE1
Bowman, JE; Gerson, SL; Lingas, KT; Reese, JS1
Cupissol, D; Cuq, P; Depeille, P; Evrard, A; Montero, JL; Passagne, I; Vian, L; Winum, JY1
Ahmed, MM; Chendil, D; Kokkinakis, DM; Moschel, RC; Pegg, AE1
Donze, JR; Gerson, SL; Lingas, KT; Reese, JS; Zielske, SP1
Bailey, BJ; Erickson, LC; Hartwell, JR; Kreklau, EL; Liu, N; Pollok, KE; Williams, DA1
Davis, BM; Dropulic, B; Humeau, L1
Dunkel, IJ; Edgar, MA; Mark, EB; Occhiogrosso, G; Souweidane, MM1
Cario-André, M; de Verneuil, H; Ged, C; Géronimi, F; Gerson, SL; Moreau-Gaudry, F; Richard, E; Robert, E1
Bacolod, MD; Bigner, DD; Bullock, NS; Colvin, OM; Dolan, ME; Fang, Q; Friedman, HS; Johnson, SP; Modrich, P; Moschel, RC; Pegg, AE1
Loktionova, NA; Moschel, RC; Pegg, AE; Wei, G1
Donze, JR; Liu, L; Yan, L1
Blank, A; Bobola, MS; Ellenbogen, RG; Geyer, JR; Goff, RD; Silber, JR1
Cai, S; Cooper, RJ; Ferkowicz, MJ; Hartwell, JR; Kelley, MR; Pollok, KE; Xu, Y1
Dolan, E; Gajewski, TF; Gerson, SL; Lin, S; Liu, L; Sosman, J; Vokes, EE1
Covas, DT; Davis, BM; Encell, LP; Fontes, AM; Gerson, SL; Lingas, K; Loeb, LA; Pegg, AE; Zago, MA1
Agamah, ES; Brockstein, BB; Delaney, SM; Dolan, ME; McLendon, R; Ryan, CW; Samuels, BL; Vokes, EE1
Delaney, SM; Dolan, ME; Hansen, RJ; Nagasubramanian, R; Samson, LD1
Chen, CC; D'Andrea, A; Taniguchi, T1
Carson, KA; Delaney, SM; Dolan, ME; Fisher, JD; Grossman, SA; Judy, K; Olivi, A; Rosenblum, ML; Tatter, SB; Weingart, J1
Bahlis, N; Batts, ED; Fu, P; Gerson, SL; Kane, D; Liu, L; Maisel, C; O'Brien, T; Remick, S1
Ball, CR; Fessler, S; Glimm, H; Pilz, IH; Schmidt, M; von Kalle, C; Williams, DA1
Adams, DM; Berg, SL; Bernstein, M; Blaney, SM; Neville, K; Zhou, T1
Ogawa, M; Ueda, T; Yamauchi, T1
Benhattar, J; Bernasconi, CC; Bricod, C; Gros, S; Janzer, RC; Juillerat-Jeanneret, L; Trepey, S1
Bigner, DD; Carter, J; Desjardins, A; Friedman, AH; Friedman, HS; Gururangan, S; Herndon, JE; Jiang, SX; McLendon, RE; Quinn, JA; Reardon, DA; Rich, JN; Sampson, JH; Threatt, S; Vredenburgh, JJ1
Alexander, IE; Gunning, PW; Hardeman, EC; Hook, J; Joya, JE; Kahatapitiya, P; Kramer, B; Lee, AS; Liu, R; McCowage, G; Montarras, D; Schevzov, G1
Choi, U; Clevenger, JR; Donahue, RE; Dunbar, CE; Kang, E; Krouse, A; Larochelle, A; Loktionova, NA; Malech, HL; Metzger, M; Naumann, N; Persons, D; Shou, Y; Sorrentino, BP; Stewart, C1
Cruz-Vallejo, VL; Morales-Ramírez, P; Vallarino-Kelly, T1
Adair, JE; Beard, BC; Ironside, C; Kiem, HP; McCune, JS; Trobridge, GD1
Apisarnthanarax, N; Carlson, S; Chan, DV; Cooper, KD; Fu, P; Gerson, SL; Gilliam, AC; Liu, L; Remick, SC; Stevens, SR; Szabo, SK; Wood, GS1
Huang, F; Jiang, Y; Pei, Y; Qian, L; Tang, Y; Wang, K; Zhang, H; Zhang, X; Zheng, J1
Adair, JE; Baldock, AL; Beard, BC; Born, DE; Bridge, CA; Gonzalez-Cuyar, LF; Gori, JL; Guyman, LA; Hawkins-Daarud, A; Johnston, SK; Kiem, HP; Mrugala, MM; Rockhill, JK; Rockne, RC; Silbergeld, DL; Storer, BE; Swanson, KR1
Jiang, Y; Li, X; Liu, C; Wang, F; Yao, S1
Carlson, S; Chan, DV; Cooper, KD; Dowlati, A; Fu, P; Gerson, SL; Groft, S; Honda, K; Lu, K; McCormick, TS; Rosenjack, J; Tacastacas, JD1

Reviews

2 review(s) available for carmustine and o(6)-benzylguanine

ArticleYear
O6-alkylguanine-DNA alkyltransferase. A target for the modulation of drug resistance.
    Hematology/oncology clinics of North America, 1995, Volume: 9, Issue:2

    Topics: Alkylating Agents; Biological Transport; Carmustine; Clinical Trials as Topic; DNA Damage; DNA Repair; DNA, Neoplasm; Drug Resistance; Guanine; Humans; Inactivation, Metabolic; Methyltransferases; Neoplasm Proteins; Neoplasms; O(6)-Methylguanine-DNA Methyltransferase

1995
O6-benzylguanine and its role in chemotherapy.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 1997, Volume: 3, Issue:6

    Topics: Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Carmustine; DNA Repair; Enzyme Inhibitors; Guanine; Humans; Neoplasms; O(6)-Methylguanine-DNA Methyltransferase; Transplantation, Heterologous

1997

Trials

13 trial(s) available for carmustine and o(6)-benzylguanine

ArticleYear
O6-benzylguanine: a clinical trial establishing the biochemical modulatory dose in tumor tissue for alkyltransferase-directed DNA repair.
    Cancer research, 1999, May-15, Volume: 59, Issue:10

    Topics: Adult; Aged; Antineoplastic Agents, Alkylating; Biopsy; Biotransformation; Breast Neoplasms; Carmustine; Digestive System Neoplasms; DNA Repair; DNA, Neoplasm; Drug Resistance, Neoplasm; Female; Guanine; Humans; Lung Neoplasms; Male; Middle Aged; Neoplasm Proteins; Neoplasms; O(6)-Methylguanine-DNA Methyltransferase; Prodrugs; Safety; Tomography, X-Ray Computed

1999
Phase I clinical and pharmacological study of O6-benzylguanine followed by carmustine in patients with advanced cancer.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2000, Volume: 6, Issue:8

    Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Carmustine; Dose-Response Relationship, Drug; Female; Guanine; Humans; Male; Middle Aged; Neoplasms; O(6)-Methylguanine-DNA Methyltransferase

2000
Phase I trial of carmustine plus O6-benzylguanine for patients with recurrent or progressive malignant glioma.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2000, Oct-15, Volume: 18, Issue:20

    Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Astrocytoma; Carmustine; Central Nervous System Neoplasms; Drug Administration Schedule; Glioblastoma; Guanine; Humans; Middle Aged; Neoplasm Recurrence, Local

2000
Phase II trial of carmustine plus O(6)-benzylguanine for patients with nitrosourea-resistant recurrent or progressive malignant glioma.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2002, May-01, Volume: 20, Issue:9

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Area Under Curve; Brain Neoplasms; Carmustine; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Resistance, Neoplasm; Female; Glioma; Guanine; Humans; Male; Middle Aged; Nitrosourea Compounds; Treatment Outcome

2002
Phase II trial of the O6-alkylguanine DNA alkyltransferase inhibitor O6-benzylguanine and 1,3-bis(2-chloroethyl)-1-nitrosourea in advanced melanoma.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2005, Nov-01, Volume: 11, Issue:21

    Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Antineoplastic Agents, Alkylating; Antineoplastic Combined Chemotherapy Protocols; Carbon Monoxide; Carmustine; Cohort Studies; Disease Progression; Female; Guanine; Humans; Leukocytes, Mononuclear; Male; Melanoma; Middle Aged; Neoplasm Metastasis; O(6)-Methylguanine-DNA Methyltransferase; Time Factors; Treatment Outcome

2005
A phase II trial of O6-benzylguanine and carmustine in patients with advanced soft tissue sarcoma.
    Cancer chemotherapy and pharmacology, 2006, Volume: 58, Issue:5

    Topics: Adult; Aged; Anemia; Antineoplastic Combined Chemotherapy Protocols; Carmustine; Enzyme Inhibitors; Female; Gastrointestinal Stromal Tumors; Guanine; Humans; Immunohistochemistry; Infant; Injections, Intravenous; Leiomyosarcoma; Male; Middle Aged; O(6)-Methylguanine-DNA Methyltransferase; Sarcoma; Survival Analysis; Tachycardia, Supraventricular; Thrombocytopenia; Treatment Outcome

2006
Phase I trial of polifeprosan 20 with carmustine implant plus continuous infusion of intravenous O6-benzylguanine in adults with recurrent malignant glioma: new approaches to brain tumor therapy CNS consortium trial.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2007, Feb-01, Volume: 25, Issue:4

    Topics: Adult; Aged; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Carmustine; Drug Delivery Systems; Female; Glioma; Guanine; Humans; Infusions, Intravenous; Male; Middle Aged; Neoplasm Recurrence, Local; O(6)-Methylguanine-DNA Methyltransferase

2007
O6-benzylguanine and BCNU in multiple myeloma: a phase II trial.
    Cancer chemotherapy and pharmacology, 2007, Volume: 60, Issue:3

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Carmustine; DNA; Drug Administration Schedule; Female; Follow-Up Studies; Guanine; Humans; Male; Middle Aged; Multiple Myeloma; Patient Selection; Reference Values

2007
Phase 1 trial of O6-benzylguanine and BCNU in children with CNS tumors: a Children's Oncology Group study.
    Pediatric blood & cancer, 2008, Volume: 50, Issue:3

    Topics: Adolescent; Antineoplastic Agents, Alkylating; Antineoplastic Combined Chemotherapy Protocols; Bone Marrow Diseases; Carmustine; Central Nervous System Neoplasms; Child; Child, Preschool; Cohort Studies; Combined Modality Therapy; DNA Repair; DNA, Neoplasm; Enzyme Inhibitors; Female; Guanine; Humans; Male; Maximum Tolerated Dose; Neoplasm Proteins; O(6)-Methylguanine-DNA Methyltransferase; Salvage Therapy

2008
Phase II trial of Gliadel plus O6-benzylguanine in adults with recurrent glioblastoma multiforme.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2009, Feb-01, Volume: 15, Issue:3

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Carmustine; Decanoic Acids; Female; Glioblastoma; Guanine; Humans; Male; Middle Aged; O(6)-Methylguanine-DNA Methyltransferase; Polyesters; Recurrence; Survival Analysis

2009
Phase I clinical trial of O6-benzylguanine and topical carmustine in the treatment of cutaneous T-cell lymphoma, mycosis fungoides type.
    Archives of dermatology, 2012, Volume: 148, Issue:5

    Topics: Administration, Topical; Adult; Aged; Aged, 80 and over; Antineoplastic Agents, Alkylating; Biomarkers, Tumor; Biopsy; Carmustine; Dose-Response Relationship, Drug; Drug Therapy, Combination; Enzyme Inhibitors; Female; Follow-Up Studies; Guanine; Humans; Infusions, Intravenous; Male; Middle Aged; Mycosis Fungoides; O(6)-Methylguanine-DNA Methyltransferase; Skin Neoplasms; Treatment Outcome

2012
Gene therapy enhances chemotherapy tolerance and efficacy in glioblastoma patients.
    The Journal of clinical investigation, 2014, Volume: 124, Issue:9

    Topics: Adult; Bone Marrow; Brain Neoplasms; Carmustine; Combined Modality Therapy; Dacarbazine; DNA Modification Methylases; DNA Repair Enzymes; Drug Resistance, Neoplasm; Female; Genetic Therapy; Glioblastoma; Guanine; Hematopoietic Stem Cell Transplantation; Humans; Male; Middle Aged; Models, Biological; Prospective Studies; Temozolomide; Tumor Suppressor Proteins

2014
Evaluation of O6-Benzylguanine-Potentiated Topical Carmustine for Mycosis Fungoides: A Phase 1-2 Clinical Trial.
    JAMA dermatology, 2017, 05-01, Volume: 153, Issue:5

    Topics: Administration, Cutaneous; Administration, Intravenous; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Carmustine; Female; Guanine; Hospitals, University; Humans; Lymphoma, T-Cell, Cutaneous; Male; Maximum Tolerated Dose; Middle Aged; Mycosis Fungoides; Neoplasm Staging; O(6)-Methylguanine-DNA Methyltransferase; Skin Neoplasms; Treatment Outcome

2017

Other Studies

92 other study(ies) available for carmustine and o(6)-benzylguanine

ArticleYear
Chemical genetics reveals a complex functional ground state of neural stem cells.
    Nature chemical biology, 2007, Volume: 3, Issue:5

    Topics: Animals; Cell Survival; Cells, Cultured; Mice; Molecular Structure; Neoplasms; Neurons; Pharmaceutical Preparations; Sensitivity and Specificity; Stem Cells

2007
Enhancement of nitrosourea activity in medulloblastoma and glioblastoma multiforme.
    Journal of the National Cancer Institute, 1992, Dec-16, Volume: 84, Issue:24

    Topics: Animals; Carmustine; Drug Resistance; Female; Glioblastoma; Guanine; Humans; Male; Medulloblastoma; Methyltransferases; Mice; Mice, Inbred BALB C; Neoplasm Transplantation; O(6)-Methylguanine-DNA Methyltransferase; Streptozocin; Transplantation, Heterologous

1992
O6-alkylguanine DNA-alkyltransferase is not a major determinant of sensitivity to 1,3-bis(2-chloroethyl)-1-nitrosourea in four medulloblastoma cell lines.
    Oncology research, 1992, Volume: 4, Issue:6

    Topics: Carmustine; Cell Survival; Cerebellar Neoplasms; Drug Resistance; Guanine; Humans; Medulloblastoma; Methyltransferases; O(6)-Methylguanine-DNA Methyltransferase; Tumor Cells, Cultured

1992
Effect of O6-benzylguanine analogues on sensitivity of human tumor cells to the cytotoxic effects of alkylating agents.
    Cancer research, 1991, Jul-01, Volume: 51, Issue:13

    Topics: Alkylating Agents; Antineoplastic Agents; Carmustine; Cell Survival; Cisplatin; Cyclophosphamide; DNA; DNA Damage; Drug Synergism; Guanine; Humans; In Vitro Techniques; Lomustine; Mesylates; Methyltransferases; O(6)-Methylguanine-DNA Methyltransferase; Streptozocin; Tumor Cells, Cultured

1991
Effect of O6-benzylguanine on the sensitivity of human tumor xenografts to 1,3-bis(2-chloroethyl)-1-nitrosourea and on DNA interstrand cross-link formation.
    Cancer research, 1992, Mar-01, Volume: 52, Issue:5

    Topics: Animals; Carmustine; Colonic Neoplasms; DNA; DNA, Neoplasm; DNA, Single-Stranded; Drug Resistance; Drug Screening Assays, Antitumor; Drug Synergism; Female; Guanine; Humans; Lomustine; Mice; Mice, Nude; Transplantation, Heterologous; Tumor Cells, Cultured

1992
Increased killing of prostate, breast, colon, and lung tumor cells by the combination of inactivators of O6-alkylguanine-DNA alkyltransferase and N,N'-bis(2-chloroethyl)-N-nitrosourea.
    Biochemical pharmacology, 1995, Oct-12, Volume: 50, Issue:8

    Topics: Antineoplastic Agents, Alkylating; Carmustine; Cell Death; Drug Resistance; Drug Therapy, Combination; Enzyme Inhibitors; Guanine; Humans; Methyltransferases; O(6)-Methylguanine-DNA Methyltransferase; Tumor Cells, Cultured

1995
Sensitization of human colon tumour cell lines to carmustine by depletion of O6-alkylguanine-DNA alkyltransferase.
    Journal of cancer research and clinical oncology, 1995, Volume: 121, Issue:4

    Topics: Carmustine; Colonic Neoplasms; Drug Resistance; Drug Screening Assays, Antitumor; Guanine; Humans; Methyltransferases; O(6)-Methylguanine-DNA Methyltransferase; Streptozocin; Time Factors; Tumor Cells, Cultured

1995
Activity of temozolomide in the treatment of central nervous system tumor xenografts.
    Cancer research, 1995, Jul-01, Volume: 55, Issue:13

    Topics: Animals; Carmustine; Central Nervous System Neoplasms; Dacarbazine; Female; Guanine; Humans; Male; Methyltransferases; Mice; Mice, Inbred BALB C; Mice, Nude; Neoplasm Transplantation; O(6)-Methylguanine-DNA Methyltransferase; Procarbazine; Temozolomide; Transplantation, Heterologous

1995
Anti-neoplastic activity of sequenced administration of O6-benzylguanine, streptozotocin, and 1,3-bis(2-chloroethyl)-1-nitrosourea in vitro and in vivo.
    Biochemical pharmacology, 1994, Nov-29, Volume: 48, Issue:11

    Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Carmustine; Glioblastoma; Guanine; Humans; Methyltransferases; Mice; Mice, Nude; O(6)-Methylguanine-DNA Methyltransferase; Streptozocin; Transplantation, Heterologous; Tumor Cells, Cultured; Tumor Stem Cell Assay

1994
Inhibition of O6-alkylguanine-DNA alkyltransferase in animal and human ovarian tumor cell lines by O6-benzylguanine and sensitization to BCNU.
    Cancer chemotherapy and pharmacology, 1995, Volume: 35, Issue:3

    Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Carmustine; Cisplatin; Cystadenocarcinoma, Serous; Drug Resistance; Female; Guanine; Humans; Methyltransferases; Middle Aged; O(6)-Methylguanine-DNA Methyltransferase; Ovarian Neoplasms; Rats; Tumor Cells, Cultured

1995
Biodistribution of O6-benzylguanine and its effectiveness against human brain tumor xenografts when given in polyethylene glycol or cremophor-EL.
    Cancer chemotherapy and pharmacology, 1994, Volume: 35, Issue:2

    Topics: Adjuvants, Pharmaceutic; Animals; Antineoplastic Agents; Carmustine; Child; Chromatography, High Pressure Liquid; Female; Glioblastoma; Glycerol; Guanine; Humans; Injections, Intraperitoneal; Male; Mice; Mice, Inbred BALB C; Mice, Nude; Neoplasm Transplantation; Polyethylene Glycols; Solubility; Tissue Distribution

1994
Extended depletion of O6-methylguanine-DNA methyltransferase activity following O6-benzyl-2'-deoxyguanosine or O6-benzylguanine combined with streptozotocin treatment enhances 1,3-bis(2-chloroethyl)-1-nitrosourea cytotoxicity.
    Cancer research, 1994, Aug-15, Volume: 54, Issue:16

    Topics: Antineoplastic Agents; Carmustine; Deoxyguanosine; Drug Resistance; Drug Screening Assays, Antitumor; Drug Synergism; Guanine; Humans; Methyltransferases; O(6)-Methylguanine-DNA Methyltransferase; Streptozocin; Tumor Cells, Cultured; Tumor Stem Cell Assay

1994
Combined depletion of O6-alkylguanine-DNA alkyltransferase and glutathione to modulate nitrosourea resistance in breast cancer.
    Biochemical pharmacology, 1994, Aug-03, Volume: 48, Issue:3

    Topics: Breast Neoplasms; Carmustine; Cell Line; Cell Survival; Drug Resistance; Ethylnitrosourea; Glutathione; Glutathione Transferase; Guanine; Humans; Methyltransferases; O(6)-Methylguanine-DNA Methyltransferase

1994
Treatment of subcutaneous and intracranial brain tumor xenografts with O6-benzylguanine and 1,3-bis(2-chloroethyl)-1-nitrosourea.
    Cancer chemotherapy and pharmacology, 1993, Volume: 32, Issue:6

    Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Carmustine; Drug Synergism; Guanine; Humans; Medulloblastoma; Methyltransferases; Mice; Mice, Inbred BALB C; Mice, Nude; Neoplasm Transplantation; O(6)-Methylguanine-DNA Methyltransferase; Time Factors

1993
The effects of O6-benzylguanine and hypoxia on the cytotoxicity of 1,3-bis(2-chloroethyl)-1-nitrosourea in nitrosourea-resistant SF-763 cells.
    Cancer chemotherapy and pharmacology, 1993, Volume: 32, Issue:6

    Topics: Biogenic Polyamines; Brain Neoplasms; Carmustine; Cell Hypoxia; Combined Modality Therapy; Drug Resistance; Guanine; Humans; Ornithine Decarboxylase; Tumor Cells, Cultured

1993
Effect of O6-benzylguanine on the sensitivity of human colon tumor xenografts to 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU).
    Biochemical pharmacology, 1993, Jul-20, Volume: 46, Issue:2

    Topics: Animals; Carmustine; Cell Division; Colonic Neoplasms; Drug Synergism; Female; Guanine; Humans; Methyltransferases; Mice; Mice, Nude; Neoplasm Transplantation; O(6)-Methylguanine-DNA Methyltransferase

1993
Prolonged depletion of O6-methylguanine DNA methyltransferase activity following exposure to O6-benzylguanine with or without streptozotocin enhances 1,3-bis(2-chloroethyl)-1-nitrosourea sensitivity in vitro.
    Cancer research, 1993, Sep-15, Volume: 53, Issue:18

    Topics: Carmustine; Cell Survival; Dose-Response Relationship, Drug; Drug Resistance; Guanine; Humans; Methyltransferases; O(6)-Methylguanine-DNA Methyltransferase; RNA, Messenger; Streptozocin; Tumor Cells, Cultured

1993
Synergistic efficacy of O6-benzylguanine and 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU) in a human colon cancer xenograft completely resistant to BCNU alone.
    Biochemical pharmacology, 1993, Jan-26, Volume: 45, Issue:2

    Topics: Alkyl and Aryl Transferases; Animals; Antineoplastic Combined Chemotherapy Protocols; Body Weight; Carmustine; Colonic Neoplasms; Drug Resistance; Drug Synergism; Guanine; Humans; Mice; Mice, Inbred BALB C; Mice, Nude; Neoplasm Transplantation; Transferases; Tumor Cells, Cultured

1993
Effect of O6-benzylguanine on the response to 1,3-bis(2-chloroethyl)-1-nitrosourea in the Dunning R3327G model of prostatic cancer.
    Cancer chemotherapy and pharmacology, 1993, Volume: 32, Issue:3

    Topics: Animals; Carmustine; Drug Interactions; Guanine; Kidney; Liver; Male; Methyltransferases; O(6)-Methylguanine-DNA Methyltransferase; Prostatic Neoplasms; Rats; Tumor Cells, Cultured

1993
Depletion of O6-methylguanine-DNA methyltransferase and potentiation of 1,3-bis(2-chloroethyl)-1-nitrosourea antitumor activity by O6-benzylguanine in vitro.
    Carcinogenesis, 1993, Volume: 14, Issue:5

    Topics: Antineoplastic Agents; Carmustine; Drug Resistance; Drug Synergism; Guanine; HeLa Cells; Humans; Kinetics; Methyltransferases; O(6)-Methylguanine-DNA Methyltransferase; Time Factors; Tumor Cells, Cultured

1993
Ubiquitination-dependent proteolysis of O6-methylguanine-DNA methyltransferase in human and murine tumor cells following inactivation with O6-benzylguanine or 1,3-bis(2-chloroethyl)-1-nitrosourea.
    Biochemistry, 1996, Jan-30, Volume: 35, Issue:4

    Topics: Adenosine Triphosphate; Animals; Blotting, Western; Carmustine; Chromatography, Affinity; Energy Metabolism; Guanine; Humans; Kinetics; Magnesium; Methyltransferases; O(6)-Methylguanine-DNA Methyltransferase; Precipitin Tests; Rats; Tumor Cells, Cultured; Ubiquitins

1996
Potentiation of temozolomide and BCNU cytotoxicity by O(6)-benzylguanine: a comparative study in vitro.
    British journal of cancer, 1996, Volume: 73, Issue:4

    Topics: Antineoplastic Agents; Antineoplastic Agents, Alkylating; Carmustine; Cell Line; Dacarbazine; Dose-Response Relationship, Drug; Drug Synergism; Guanine; Humans; Methyltransferases; O(6)-Methylguanine-DNA Methyltransferase; Temozolomide; Tumor Cells, Cultured

1996
Point mutations in human O6-alkylguanine-DNA alkyltransferase prevent the sensitization by O6-benzylguanine to killing by N,N'-bis (2-chloroethyl)-N-nitrosourea.
    Cancer research, 1996, Apr-01, Volume: 56, Issue:7

    Topics: Animals; Antineoplastic Agents; Base Sequence; Carmustine; Cell Survival; CHO Cells; Cricetinae; Drug Resistance; Guanine; Humans; Methyltransferases; Molecular Sequence Data; O(6)-Methylguanine-DNA Methyltransferase; Point Mutation; Transfection

1996
Differential sensitivity of human and mouse alkyltransferase to O6-benzylguanine using a transgenic model.
    Cancer research, 1996, Apr-15, Volume: 56, Issue:8

    Topics: Animals; Antineoplastic Agents; Base Sequence; Carmustine; CHO Cells; Cricetinae; DNA Primers; Genetic Vectors; Guanine; Humans; Liver; Methyltransferases; Mice; Mice, Nude; Mice, Transgenic; Molecular Sequence Data; O(6)-Methylguanine-DNA Methyltransferase; Polymerase Chain Reaction; Recombinant Fusion Proteins; Transfection

1996
O6-benzylguanine enhances the sensitivity of a glioma xenograft with low O6-alkylguanine-DNA alkyltransferase activity to temozolomide and BCNU.
    British journal of cancer, 1996, Volume: 73, Issue:9

    Topics: Animals; Antineoplastic Agents; Astrocytoma; Body Weight; Carmustine; Cell Division; Cell Line; Dacarbazine; Glioblastoma; Guanine; Humans; Kinetics; Methyltransferases; Mice; Mice, Nude; O(6)-Methylguanine-DNA Methyltransferase; Temozolomide; Time Factors; Transplantation, Heterologous; Tumor Cells, Cultured

1996
Enhancement of melphalan activity by inhibition of DNA polymerase-alpha and DNA polymerase-beta.
    Cancer chemotherapy and pharmacology, 1996, Volume: 38, Issue:4

    Topics: Animals; Antineoplastic Agents; Antineoplastic Agents, Alkylating; Aphidicolin; Carmustine; DNA Polymerase I; DNA Polymerase II; Drug Synergism; Enzyme Inhibitors; Female; Guanine; Humans; Male; Melphalan; Mice; Mice, Inbred BALB C; Mice, Nude; Neoplasm Transplantation; Rhabdomyosarcoma; Zalcitabine

1996
Human CD34+ hematopoietic progenitors have low, cytokine-unresponsive O6-alkylguanine-DNA alkyltransferase and are sensitive to O6-benzylguanine plus BCNU.
    Blood, 1996, Sep-01, Volume: 88, Issue:5

    Topics: Adult; Antigens, CD34; Antineoplastic Agents; Antineoplastic Agents, Alkylating; Bone Marrow Cells; Carmustine; Cells, Cultured; Colony-Forming Units Assay; Culture Media, Conditioned; DNA Damage; DNA Repair; Drug Resistance; Drug Synergism; Enzyme Inhibitors; Erythropoietin; Granulocyte-Macrophage Colony-Stimulating Factor; Guanine; Hematopoietic Stem Cells; Humans; Interleukin-3; Methyltransferases; O(6)-Methylguanine-DNA Methyltransferase; Recombinant Proteins; Stem Cell Factor

1996
Cytotoxicity of fluoroethylating agents is potentiated by O6-benzylguanine.
    Biological & pharmaceutical bulletin, 1996, Volume: 19, Issue:7

    Topics: Antineoplastic Agents; Antineoplastic Agents, Alkylating; Carmustine; Cell Survival; Drug Synergism; Guanine; HeLa Cells; Humans; Iodoacetamide; Lomustine; Nimustine

1996
3-aminobenzamide and/or O6-benzylguanine evaluated as an adjuvant to temozolomide or BCNU treatment in cell lines of variable mismatch repair status and O6-alkylguanine-DNA alkyltransferase activity.
    British journal of cancer, 1996, Volume: 74, Issue:7

    Topics: Antineoplastic Agents, Alkylating; Benzamides; Carmustine; Dacarbazine; DNA Repair; Drug Screening Assays, Antitumor; Drug Synergism; Enzyme Inhibitors; Guanine; Humans; Neoplasms; Temozolomide; Tumor Cells, Cultured

1996
Retroviral transduction of a mutant methylguanine DNA methyltransferase gene into human CD34 cells confers resistance to O6-benzylguanine plus 1,3-bis(2-chloroethyl)-1-nitrosourea.
    Proceedings of the National Academy of Sciences of the United States of America, 1996, Nov-26, Volume: 93, Issue:24

    Topics: Animals; Antigens, CD34; Antineoplastic Agents; Carmustine; Cell Line; Cell Survival; CHO Cells; Cricetinae; DNA Primers; Dose-Response Relationship, Drug; Drug Resistance; Guanine; Humans; Leukemia, Erythroblastic, Acute; Methyltransferases; Mutagenesis; O(6)-Methylguanine-DNA Methyltransferase; Polymerase Chain Reaction; Recombinant Proteins; Transfection

1996
Mismatch repair mutations override alkyltransferase in conferring resistance to temozolomide but not to 1,3-bis(2-chloroethyl)nitrosourea.
    Cancer research, 1996, Dec-01, Volume: 56, Issue:23

    Topics: Antineoplastic Agents, Alkylating; Carmustine; Colonic Neoplasms; Dacarbazine; DNA Adducts; DNA Damage; DNA Repair; Drug Resistance, Neoplasm; Enzyme Inhibitors; Guanine; Humans; Methylation; Methyltransferases; Microsatellite Repeats; Mutation; O(6)-Methylguanine-DNA Methyltransferase; Phenotype; Temozolomide; Tumor Cells, Cultured; Tumor Stem Cell Assay

1996
Intraarterial O6-benzylguanine enables the specific therapy of nitrosourea-resistant intracranial human glioma xenografts in athymic rats with 1,3-bis(2-chloroethyl)-1-nitrosourea.
    Cancer chemotherapy and pharmacology, 1997, Volume: 39, Issue:4

    Topics: Alkyl and Aryl Transferases; Animals; Antineoplastic Agents, Alkylating; Brain Neoplasms; Carmustine; DNA Repair; Drug Resistance, Neoplasm; Glioblastoma; Guanine; Humans; Injections, Intra-Arterial; Rats; Rats, Nude; Transferases; Transplantation, Heterologous

1997
O6-benzylguanine potentiates the in vivo toxicity and clastogenicity of temozolomide and BCNU in mouse bone marrow.
    Blood, 1997, Mar-01, Volume: 89, Issue:5

    Topics: Animals; Antineoplastic Agents; Bone Marrow; Bone Marrow Cells; Carmustine; Cell Division; Dacarbazine; Drug Synergism; Female; Guanine; Hematopoietic Stem Cells; Male; Mice; Temozolomide

1997
Role of O6-methylguanine-DNA methyltransferase, glutathione transferase M3-3 and glutathione in resistance to carmustine in a human non-small cell lung cancer cell line.
    European journal of cancer (Oxford, England : 1990), 1997, Volume: 33, Issue:3

    Topics: Antineoplastic Agents, Alkylating; Carcinoma, Non-Small-Cell Lung; Carmustine; Dose-Response Relationship, Drug; Drug Resistance, Neoplasm; Glutathione; Glutathione Transferase; Guanine; Humans; Lung Neoplasms; Methyltransferases; O(6)-Methylguanine-DNA Methyltransferase; Tumor Cells, Cultured

1997
O6-methylguanine-DNA methyltransferase (MGMT) transfectants of a 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU)-sensitive colon cancer cell line selectively repopulate heterogenous MGMT+/MGMT- xenografts after BCNU and O6-benzylguanine plus BCNU.
    Cancer research, 1997, Nov-01, Volume: 57, Issue:21

    Topics: Animals; Antineoplastic Agents; Carmustine; Colonic Neoplasms; DNA Repair; Drug Resistance, Neoplasm; Female; Guanine; Humans; Mice; Mice, Nude; Neoplasm Proteins; O(6)-Methylguanine-DNA Methyltransferase; Transfection; Transplantation, Heterologous; Tumor Cells, Cultured

1997
Selection for G156A O6-methylguanine DNA methyltransferase gene-transduced hematopoietic progenitors and protection from lethality in mice treated with O6-benzylguanine and 1,3-bis(2-chloroethyl)-1-nitrosourea.
    Cancer research, 1997, Nov-15, Volume: 57, Issue:22

    Topics: Animals; Antineoplastic Agents; Carmustine; Cell Survival; Drug Resistance, Neoplasm; Genetic Vectors; Guanine; Hematopoietic Stem Cell Transplantation; Hematopoietic Stem Cells; Male; Mice; Mice, Inbred C3H; O(6)-Methylguanine-DNA Methyltransferase; Retroviridae; Transfection

1997
Retroviral transfer of a bacterial alkyltransferase gene (ada) into human bone marrow cells protects against O6-benzylguanine plus 1, 3-bis(2-chloroethyl)-1-nitrosourea cytotoxicity.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 1997, Volume: 3, Issue:2

    Topics: 3T3 Cells; Adolescent; Adult; Alkyl and Aryl Transferases; Animals; Antineoplastic Combined Chemotherapy Protocols; Bone Marrow Cells; Carmustine; Cell Survival; Female; Genetic Vectors; Guanine; Humans; Infant, Newborn; Male; Mice; Protective Agents; Retroviridae; Stem Cells; Transduction, Genetic

1997
Retroviral transfer of a bacterial alkyltransferase gene into murine bone marrow protects against chloroethylnitrosourea cytotoxicity.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 1995, Volume: 1, Issue:11

    Topics: Animals; Antineoplastic Agents, Alkylating; Bacterial Proteins; Bone Marrow; Carmustine; Enzyme Inhibitors; Escherichia coli Proteins; Ethylnitrosourea; Feasibility Studies; Gene Transfer Techniques; Guanine; Mice; Mice, Inbred CBA; O(6)-Methylguanine-DNA Methyltransferase; Retroviridae; Transcription Factors

1995
Simultaneous protection of G156A methylguanine DNA methyltransferase gene-transduced hematopoietic progenitors and sensitization of tumor cells using O6-benzylguanine and temozolomide.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 1999, Volume: 5, Issue:1

    Topics: Animals; Antineoplastic Agents; Antineoplastic Agents, Alkylating; Carmustine; Colonic Neoplasms; Dacarbazine; Drug Combinations; Drug Resistance, Neoplasm; Guanine; Hematopoietic Stem Cells; Humans; Male; Mice; Mice, Inbred C3H; O(6)-Methylguanine-DNA Methyltransferase; Temozolomide; Transduction, Genetic; Transfection; Tumor Cells, Cultured

1999
Influence of O6-benzylguanine on the anti-tumour activity and normal tissue toxicity of 1,3-bis(2-chloroethyl)-1-nitrosourea and molecular combinations of 5-fluorouracil and 2-chloroethyl-1-nitrosourea in mice.
    British journal of cancer, 1999, Volume: 79, Issue:9-10

    Topics: Animals; Antineoplastic Agents, Alkylating; Carmustine; Colony-Forming Units Assay; Drug Combinations; Drug Resistance, Neoplasm; Enzyme Inhibitors; Ethylnitrosourea; Fluorouracil; Guanine; Humans; Male; Mice; Mice, Nude; O(6)-Methylguanine-DNA Methyltransferase; Tumor Stem Cell Assay

1999
DeltaMGMT-transduced bone marrow infusion increases tolerance to O6-benzylguanine and 1,3-bis(2-chloroethyl)-1-nitrosourea and allows intensive therapy of 1,3-bis(2-chloroethyl)-1-nitrosourea-resistant human colon cancer xenografts.
    Human gene therapy, 1999, Apr-10, Volume: 10, Issue:6

    Topics: Animals; Antineoplastic Agents, Alkylating; Bone Marrow Transplantation; Carmustine; Cell Division; Colonic Neoplasms; Combined Modality Therapy; Drug Resistance, Neoplasm; Genetic Vectors; Guanine; Humans; Mice; Mice, Nude; Neoplasm Transplantation; O(6)-Methylguanine-DNA Methyltransferase; Retroviridae; Transduction, Genetic

1999
Protection of CHO cells by mutant forms of O6-alkylguanine-DNA alkyltransferase from killing by 1,3-bis-(2-chloroethyl)-1-nitrosourea (BCNU) plus O6-benzylguanine or O6-benzyl-8-oxoguanine.
    Biochemical pharmacology, 1999, Jul-15, Volume: 58, Issue:2

    Topics: Animals; Antineoplastic Agents, Alkylating; Carmustine; Cell Survival; CHO Cells; Cricetinae; Drug Interactions; Drug Resistance, Neoplasm; Enzyme Inhibitors; Guanine; Humans; Mutation; O(6)-Methylguanine-DNA Methyltransferase

1999
Acquired resistance to O6-benzylguanine plus chloroethylnitrosoureas in human breast cancer.
    Cancer chemotherapy and pharmacology, 1999, Volume: 44, Issue:4

    Topics: Antineoplastic Agents, Alkylating; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Carmustine; Drug Resistance, Neoplasm; Drug Synergism; Ethylnitrosourea; Glutathione; Guanine; Humans; O(6)-Methylguanine-DNA Methyltransferase; Tumor Cells, Cultured

1999
Protection of committed murine haemopoietic progenitors against BCNU toxicity does not predict protection of primitive, multipotent spleen colony-forming cells - implications for chemoprotective gene therapy.
    Leukemia, 1999, Volume: 13, Issue:11

    Topics: Animals; Antineoplastic Agents; Carmustine; Cells, Cultured; Colony-Forming Units Assay; Drug Resistance, Neoplasm; Erythrocytes; Genetic Therapy; Granulocytes; Guanine; Hematopoietic Stem Cells; Humans; Immunohistochemistry; Macrophages; Male; Mice; Micronucleus Tests; Mutagens; Mutation; Nucleotidyltransferases; Spleen; Transduction, Genetic

1999
Prolonged inhibition of O(6)-methylguanine DNA methyltransferase in human tumor cells by O(6)-benzylguanine in vitro and in vivo.
    The Journal of pharmacology and experimental therapeutics, 1999, Volume: 291, Issue:3

    Topics: Animals; Antineoplastic Agents, Alkylating; Brain Neoplasms; Carmustine; Enzyme Inhibitors; Female; Glioma; Guanine; Humans; Male; Mice; Mice, Inbred NOD; Mice, SCID; Neoplasm Transplantation; O(6)-Methylguanine-DNA Methyltransferase; Tumor Cells, Cultured

1999
Characterization of the P140K, PVP(138-140)MLK, and G156A O6-methylguanine-DNA methyltransferase mutants: implications for drug resistance gene therapy.
    Human gene therapy, 1999, Nov-20, Volume: 10, Issue:17

    Topics: Antineoplastic Agents; Carmustine; Cell Survival; Cloning, Molecular; Drug Interactions; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Enzyme Stability; Gene Expression; Genetic Therapy; Guanine; Humans; K562 Cells; Mutation; O(6)-Methylguanine-DNA Methyltransferase; Transfection

1999
Potentiation of BCNU antitumor efficacy by 9-substituted O6-benzylguanines. Effect of metabolism.
    Cancer chemotherapy and pharmacology, 2000, Volume: 45, Issue:1

    Topics: Animals; Antineoplastic Agents; Brain; Carmustine; Drug Synergism; Guanine; Humans; Mice; Mice, Inbred BALB C; Mice, Nude; O(6)-Methylguanine-DNA Methyltransferase; Rats; Rats, Sprague-Dawley

2000
Conserved residue lysine165 is essential for the ability of O6-alkylguanine-DNA alkyltransferase to react with O6-benzylguanine.
    The Biochemical journal, 2000, Apr-15, Volume: 347, Issue:Pt 2

    Topics: Amino Acid Sequence; Amino Acid Substitution; Animals; Antineoplastic Agents; Binding Sites; Carmustine; CHO Cells; Conserved Sequence; Cricetinae; DNA; DNA Repair; Drug Resistance; Escherichia coli; Guanine; Humans; Lysine; Methylnitronitrosoguanidine; Molecular Sequence Data; Mutation; O(6)-Methylguanine-DNA Methyltransferase; Protein Binding; Sequence Alignment; Transfection

2000
Limiting numbers of G156A O(6)-methylguanine-DNA methyltransferase-transduced marrow progenitors repopulate nonmyeloablated mice after drug selection.
    Blood, 2000, May-15, Volume: 95, Issue:10

    Topics: Animals; Antineoplastic Agents; Blood Cell Count; Carmustine; Cell Differentiation; Cell Division; Gene Transfer Techniques; Guanine; Hematopoietic Stem Cell Transplantation; Hematopoietic Stem Cells; Mice; O(6)-Methylguanine-DNA Methyltransferase

2000
O6-benzylguanine-mediated enhancement of nitrosourea activity in Mer- central nervous system tumor xenografts--implications for clinical trials.
    Cancer chemotherapy and pharmacology, 2000, Volume: 45, Issue:6

    Topics: Animals; Antineoplastic Agents; Carmustine; Central Nervous System Neoplasms; Clinical Trials as Topic; Enzyme Inhibitors; Female; Guanine; Humans; Male; Mice; Mice, Inbred BALB C; Mice, Nude; Neoplasm Transplantation; O(6)-Methylguanine-DNA Methyltransferase; Transplantation, Heterologous

2000
Role of O6-alkylguanine-DNA alkyltransferase in the resistance of mouse spermatogenic cells to O6-alkylating agents.
    Journal of reproduction and fertility, 2000, Volume: 119, Issue:2

    Topics: Analysis of Variance; Animals; Antineoplastic Agents, Alkylating; Apoptosis; Carmustine; DNA Repair; Drug Resistance; Enzyme Inhibitors; Guanine; Half-Life; In Situ Nick-End Labeling; Male; Mice; Mice, Inbred BALB C; O(6)-Methylguanine-DNA Methyltransferase; Seminiferous Epithelium; Spermatogonia; Testis; Time Factors

2000
Potentiation of BCNU anticancer activity by O6-benzylguanine: a study in vitro and in vivo.
    Journal of environmental pathology, toxicology and oncology : official organ of the International Society for Environmental Toxicology and Cancer, 2000, Volume: 19, Issue:1-2

    Topics: Alkyl and Aryl Transferases; Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Carmustine; Cell Survival; Drug Synergism; Guanine; Humans; Injections, Subcutaneous; Mice; Mice, Inbred BALB C; Mice, Nude; Neoplasm Transplantation; Stomach Neoplasms; Transplantation, Heterologous; Tumor Cells, Cultured

2000
Protection of hematopoietic cells against combined O6-benzylguanine and chloroethylnitrosourea treatment by mutant forms of O6-methylguanine DNA methyltransferase.
    Bone marrow transplantation, 2000, Volume: 25 Suppl 2

    Topics: Animals; Antineoplastic Agents; Carmustine; DNA Repair; Drug Resistance; Gene Expression; Genetic Therapy; Guanine; Hematopoietic Stem Cell Transplantation; Hematopoietic Stem Cells; Leukemia L1210; Mice; Mutation; O(6)-Methylguanine-DNA Methyltransferase; Retroviridae; Transduction, Genetic

2000
Can O6-alkylguanine-DNA alkyltransferase depletion enhance alkylator activity in the clinic?
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2000, Volume: 6, Issue:8

    Topics: Antineoplastic Agents, Alkylating; Antineoplastic Combined Chemotherapy Protocols; Carmustine; Drug Synergism; Enzyme Activation; Enzyme Inhibitors; Guanine; Humans; O(6)-Methylguanine-DNA Methyltransferase

2000
Direct reversal of DNA damage by mutant methyltransferase protein protects mice against dose-intensified chemotherapy and leads to in vivo selection of hematopoietic stem cells.
    Cancer research, 2000, Sep-15, Volume: 60, Issue:18

    Topics: 3T3 Cells; Animals; Antineoplastic Combined Chemotherapy Protocols; Bone Marrow Transplantation; Carmustine; DNA Damage; DNA Repair; Dose-Response Relationship, Drug; Gene Transfer Techniques; Genetic Vectors; Guanine; Hematopoietic Stem Cells; Humans; Mice; Mice, Inbred C57BL; O(6)-Methylguanine-DNA Methyltransferase; Point Mutation; Rats; Retroviridae; Transduction, Genetic

2000
Effect of O6-benzylguanine on alkylating agent-induced toxicity and mutagenicity. In Chinese hamster ovary cells expressing wild-type and mutant O6-alkylguanine-DNA alkyltransferases.
    Cancer research, 2000, Oct-01, Volume: 60, Issue:19

    Topics: Animals; Antineoplastic Agents, Alkylating; Carmustine; CHO Cells; Cricetinae; Cyclophosphamide; Dacarbazine; Drug Interactions; Enzyme Inhibitors; Guanine; Mutagenicity Tests; Mutagens; O(6)-Methylguanine-DNA Methyltransferase; Temozolomide

2000
O6-benzylguanine potentiates the antitumor effect of locally delivered carmustine against an intracranial rat glioma.
    Cancer research, 2000, Nov-15, Volume: 60, Issue:22

    Topics: Animals; Antineoplastic Agents, Alkylating; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Carmustine; Drug Implants; Drug Synergism; Enzyme Inhibitors; Glioma; Gliosarcoma; Guanine; Humans; Male; Medulloblastoma; O(6)-Methylguanine-DNA Methyltransferase; Rats; Rats, Inbred F344; Stereotaxic Techniques; Tumor Cells, Cultured; Xenograft Model Antitumor Assays

2000
Inactivation of human O(6)-alkylguanine-DNA alkyltransferase by modified oligodeoxyribonucleotides containing O(6)-benzylguanine.
    The Journal of pharmacology and experimental therapeutics, 2001, Volume: 296, Issue:3

    Topics: Antineoplastic Agents, Alkylating; Carmustine; Cell Survival; Drug Resistance; Enzyme Inhibitors; Enzyme Repression; Guanine; HT29 Cells; Humans; O(6)-Methylguanine-DNA Methyltransferase; Oligodeoxyribonucleotides; Organophosphorus Compounds

2001
Thresholds of O6-alkylguanine-DNA alkyltransferase which confer significant resistance of human glial tumor xenografts to treatment with 1,3-bis(2-chloroethyl)-1-nitrosourea or temozolomide.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2001, Volume: 7, Issue:2

    Topics: Animals; Antineoplastic Agents, Alkylating; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Carmustine; Dacarbazine; Deoxyguanosine; Drug Resistance, Neoplasm; Enzyme Inhibitors; Glioma; Guanine; Humans; Mice; Mice, Nude; O(6)-Methylguanine-DNA Methyltransferase; Temozolomide; Transplantation, Heterologous; Tumor Cells, Cultured

2001
Applied molecular evolution of O6-benzylguanine-resistant DNA alkyltransferases in human hematopoietic cells.
    Proceedings of the National Academy of Sciences of the United States of America, 2001, Apr-24, Volume: 98, Issue:9

    Topics: Amino Acid Sequence; Antineoplastic Agents; Carmustine; Cell Death; Cell Survival; Directed Molecular Evolution; Drug Resistance, Neoplasm; Enzyme Stability; Gene Library; Genetic Therapy; Guanine; Humans; K562 Cells; Molecular Sequence Data; Mutation; O(6)-Methylguanine-DNA Methyltransferase; Transduction, Genetic

2001
O6-Benzylguanine potentiates BCNU but not busulfan toxicity in hematopoietic stem cells.
    Experimental hematology, 2001, Volume: 29, Issue:5

    Topics: Alkylation; Animals; Antineoplastic Agents, Alkylating; Busulfan; Carmustine; Cell Line; CHO Cells; Coculture Techniques; Colony-Forming Units Assay; Cricetinae; Cricetulus; DNA Damage; DNA Repair; Erythroid Precursor Cells; Fibroblasts; Guanine; Hematopoietic Stem Cells; Humans; Male; Mice; Mice, Inbred C57BL; O(6)-Methylguanine-DNA Methyltransferase; Stromal Cells; Transfection

2001
Sequential tumor biopsies in early phase clinical trials of anticancer agents for pharmacodynamic evaluation.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2001, Volume: 7, Issue:10

    Topics: Animals; Antineoplastic Agents; Biopsy; Carmustine; Cisplatin; Clinical Trials, Phase I as Topic; Clinical Trials, Phase II as Topic; Doxorubicin; Fenretinide; Guanine; Humans; Indoles; Neoplasms; O(6)-Methylguanine-DNA Methyltransferase; Paclitaxel; Pyrroles; Tomography, X-Ray Computed; Treatment Outcome; Xenograft Model Antitumor Assays

2001
G156A MGMT-transduced human mesenchymal stem cells can be selectively enriched by O6-benzylguanine and BCNU.
    Journal of hematotherapy & stem cell research, 2001, Volume: 10, Issue:5

    Topics: Animals; Antineoplastic Agents; Bone Marrow Cells; Brain; Carmustine; Cell Survival; Cell Transplantation; Cells, Cultured; DNA; Dose-Response Relationship, Drug; Drug Resistance, Multiple; Dystrophin; Flow Cytometry; Genetic Vectors; Green Fluorescent Proteins; Guanine; Humans; Infusions, Intravenous; Liver; Luminescent Proteins; Lung; Mesoderm; Mice; Mice, Inbred NOD; Mice, SCID; Mutation, Missense; O(6)-Methylguanine-DNA Methyltransferase; Recombinant Fusion Proteins; Retroviridae; Spleen; Stem Cells; Tissue Distribution; Transfection

2001
Role of cytochrome P450 isoenzymes in metabolism of O(6)-benzylguanine: implications for dacarbazine activation.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2001, Volume: 7, Issue:12

    Topics: Antineoplastic Agents; Biotransformation; Carmustine; Cytochrome P-450 Enzyme System; Cytosol; Dacarbazine; DNA Repair; Guanine; Humans; Isoenzymes; Kinetics; Liver; Microsomes, Liver; Temozolomide

2001
Chemotherapy-induced O(6)-benzylguanine-resistant alkyltransferase mutations in mismatch-deficient colon cancer.
    Cancer research, 2002, Jun-01, Volume: 62, Issue:11

    Topics: Adaptor Proteins, Signal Transducing; Alkyl and Aryl Transferases; Animals; Antineoplastic Agents, Alkylating; Antineoplastic Combined Chemotherapy Protocols; Base Pair Mismatch; Carmustine; Carrier Proteins; CHO Cells; Colonic Neoplasms; Cricetinae; DNA Repair; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Drug Synergism; Genes, p53; Guanine; Humans; Mutagenesis; Mutation; MutL Protein Homolog 1; Neoplasm Proteins; Nuclear Proteins; O(6)-Methylguanine-DNA Methyltransferase; RNA, Messenger; Tumor Cells, Cultured

2002
Toxicity of intracranial and intraperitoneal O6-benzyl guanine in combination with BCNU delivered locally in a mouse model.
    Cancer chemotherapy and pharmacology, 2002, Volume: 50, Issue:5

    Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Bone Marrow Diseases; Carmustine; Dose-Response Relationship, Drug; Drug Implants; Drug Synergism; Guanine; Inflammation; Infusion Pumps, Implantable; Infusions, Parenteral; Mice; Mice, Inbred BALB C; Necrosis; Parietal Lobe; Peritoneal Cavity

2002
O6-benzylguanine-mediated enhancement of chemotherapy.
    Molecular cancer therapeutics, 2002, Volume: 1, Issue:11

    Topics: Animals; Antineoplastic Agents; Antineoplastic Agents, Alkylating; Camptothecin; Carmustine; Central Nervous System Neoplasms; Cyclophosphamide; Dacarbazine; DNA; Enzyme Inhibitors; Female; Guanine; Humans; Irinotecan; Male; Mice; Mice, Inbred BALB C; Mice, Nude; Neoplasm Transplantation; Protein Synthesis Inhibitors; Temozolomide

2002
Myeloablation is not required to select and maintain expression of the drug-resistance gene, mutant MGMT, in primary and secondary recipients.
    Molecular therapy : the journal of the American Society of Gene Therapy, 2003, Volume: 8, Issue:1

    Topics: Animals; Antineoplastic Agents, Alkylating; Blotting, Southern; Bone Marrow Cells; Bone Marrow Transplantation; Carmustine; Cell Separation; Dose-Response Relationship, Drug; Drug Resistance; Enzyme Inhibitors; Flow Cytometry; Gene Transfer Techniques; Genetic Therapy; Genetic Vectors; Guanine; Humans; Mice; Mice, Inbred C3H; Models, Genetic; Mutation; Neoplasm Transplantation; O(6)-Methylguanine-DNA Methyltransferase; Polymerase Chain Reaction; Stem Cells; Time Factors

2003
Cytotoxicity, DNA damage, and apoptosis induced by new fotemustine analogs on human melanoma cells in relation to O6-methylguanine DNA-methyltransferase expression.
    The Journal of pharmacology and experimental therapeutics, 2003, Volume: 307, Issue:2

    Topics: Antineoplastic Agents; Apoptosis; Carmustine; DNA Damage; Enzyme Inhibitors; Enzyme-Linked Immunosorbent Assay; Guanine; Humans; Melanoma; Nitrosourea Compounds; O(6)-Methylguanine-DNA Methyltransferase; Organophosphorus Compounds; Tumor Cells, Cultured

2003
Sensitization of pancreatic tumor xenografts to carmustine and temozolomide by inactivation of their O6-Methylguanine-DNA methyltransferase with O6-benzylguanine or O6-benzyl-2'-deoxyguanosine.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2003, Sep-01, Volume: 9, Issue:10 Pt 1

    Topics: Alkylating Agents; Animals; Antineoplastic Agents, Alkylating; Carmustine; Cell Line, Tumor; Dacarbazine; Deoxyguanosine; DNA Repair; Dose-Response Relationship, Drug; Enzyme Inhibitors; Guanine; Humans; Male; Mice; Mice, Nude; Neoplasm Transplantation; Neoplasms, Experimental; O(6)-Methylguanine-DNA Methyltransferase; Pancreatic Neoplasms; Temozolomide; Time Factors

2003
In vivo selection of MGMT(P140K) lentivirus-transduced human NOD/SCID repopulating cells without pretransplant irradiation conditioning.
    The Journal of clinical investigation, 2003, Volume: 112, Issue:10

    Topics: Animals; Antigens, CD34; Antineoplastic Agents; Carmustine; Gene Transfer Techniques; Genetic Vectors; Guanine; Hematopoietic Stem Cell Transplantation; Hematopoietic Stem Cells; Humans; Lentivirus; Mice; Mice, SCID; O(6)-Methylguanine-DNA Methyltransferase; Radiation; Severe Combined Immunodeficiency; Transduction, Genetic; Transgenes; Transplantation Conditioning

2003
Hematopoietic expression of O(6)-methylguanine DNA methyltransferase-P140K allows intensive treatment of human glioma xenografts with combination O(6)-benzylguanine and 1,3-bis-(2-chloroethyl)-1-nitrosourea.
    Molecular cancer therapeutics, 2003, Volume: 2, Issue:12

    Topics: Animals; Antineoplastic Agents, Alkylating; Bone Marrow; Brain Neoplasms; Carmustine; Glioma; Guanine; Humans; Mice; Mice, Inbred NOD; Mice, SCID; O(6)-Methylguanine-DNA Methyltransferase; Transduction, Genetic; Transplantation, Heterologous

2003
In vivo selection for human and murine hematopoietic cells transduced with a therapeutic MGMT lentiviral vector that inhibits HIV replication.
    Molecular therapy : the journal of the American Society of Gene Therapy, 2004, Volume: 9, Issue:2

    Topics: Animals; Carmustine; Flow Cytometry; Gene Products, env; Genetic Vectors; Guanine; Hematopoietic Stem Cells; HIV-1; Humans; Lentivirus; Mice; Mice, Inbred NOD; Mice, SCID; O(6)-Methylguanine-DNA Methyltransferase; T-Lymphocytes; Transduction, Genetic; Virus Replication

2004
Interstitial infusion of carmustine in the rat brain stem with systemic administration of O6-benzylguanine.
    Journal of neuro-oncology, 2004, Volume: 67, Issue:3

    Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Brain Stem; Carmustine; Guanine; Infusion Pumps; Injections, Intraperitoneal; Macrophages; Male; Neutrophils; Rats; Rats, Sprague-Dawley; Stereotaxic Techniques

2004
Hematopoietic stem cell gene therapy of murine protoporphyria by methylguanine-DNA-methyltransferase-mediated in vivo drug selection.
    Gene therapy, 2004, Volume: 11, Issue:22

    Topics: Animals; Antineoplastic Agents; Carmustine; Female; Ferrochelatase; Genetic Engineering; Genetic Therapy; Genetic Vectors; Guanine; Lentivirus; Male; Mice; Mice, Inbred BALB C; Models, Animal; O(6)-Methylguanine-DNA Methyltransferase; Protoporphyria, Erythropoietic; Stem Cell Transplantation; Stem Cells; Transduction, Genetic

2004
Brain tumor cell lines resistant to O6-benzylguanine/1,3-bis(2-chloroethyl)-1-nitrosourea chemotherapy have O6-alkylguanine-DNA alkyltransferase mutations.
    Molecular cancer therapeutics, 2004, Volume: 3, Issue:9

    Topics: Antineoplastic Agents; Brain Neoplasms; Carmustine; Cell Line, Tumor; Deoxyguanosine; Drug Resistance, Neoplasm; Guanine; Humans; Mutation; O(6)-Methylguanine-DNA Methyltransferase; Polymorphism, Genetic

2004
Beta-glucuronidase-cleavable prodrugs of O6-benzylguanine and O6-benzyl-2'-deoxyguanosine.
    Journal of medicinal chemistry, 2005, Jan-13, Volume: 48, Issue:1

    Topics: Alkyl and Aryl Transferases; Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Biochemistry; Carmustine; Cattle; Cell Death; Deoxyguanosine; Drug Stability; Enzyme Activation; Escherichia coli; Glucuronidase; Guanine; HT29 Cells; Humans; Hydrolysis; Kinetics; Liver; Prodrugs

2005
Inactivated MGMT by O6-benzylguanine is associated with prolonged G2/M arrest in cancer cells treated with BCNU.
    Oncogene, 2005, Mar-24, Volume: 24, Issue:13

    Topics: Amino Acid Substitution; Carmustine; Cell Cycle; Cell Death; Cell Division; Cell Line, Tumor; DNA Damage; Drug Resistance, Neoplasm; G2 Phase; Guanine; Humans; Mutagenesis, Site-Directed; O(6)-Methylguanine-DNA Methyltransferase

2005
O6-methylguanine-DNA methyltransferase, O6-benzylguanine, and resistance to clinical alkylators in pediatric primary brain tumor cell lines.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2005, Apr-01, Volume: 11, Issue:7

    Topics: Adolescent; Antineoplastic Agents, Alkylating; Brain; Carmustine; Cell Survival; Child; Child, Preschool; Dacarbazine; Dose-Response Relationship, Drug; Drug Resistance, Neoplasm; Drug Synergism; Enzyme Inhibitors; Female; Guanine; Humans; Male; O(6)-Methylguanine-DNA Methyltransferase; Temozolomide; Time Factors; Tumor Cells, Cultured

2005
Mitochondrial targeting of human O6-methylguanine DNA methyltransferase protects against cell killing by chemotherapeutic alkylating agents.
    Cancer research, 2005, Apr-15, Volume: 65, Issue:8

    Topics: Antigens, CD34; Antineoplastic Agents, Alkylating; Carmustine; Cell Death; Cell Nucleus; Dacarbazine; DNA Damage; DNA Repair; Drug Resistance, Neoplasm; Guanine; Hematopoietic Stem Cells; Humans; K562 Cells; Methyl Methanesulfonate; Mitochondria; O(6)-Methylguanine-DNA Methyltransferase; Temozolomide; Transfection

2005
Differential competitive resistance to methylating versus chloroethylating agents among five O6-alkylguanine DNA alkyltransferases in human hematopoietic cells.
    Molecular cancer therapeutics, 2006, Volume: 5, Issue:1

    Topics: Alkylating Agents; Carmustine; Dacarbazine; Drug Resistance; Genetic Engineering; Guanine; Hematopoietic Stem Cells; Humans; K562 Cells; Mutation; O(6)-Methylguanine-DNA Methyltransferase; Temozolomide; Transduction, Genetic

2006
Role of O6-methylguanine-DNA methyltransferase in protecting from alkylating agent-induced toxicity and mutations in mice.
    Carcinogenesis, 2007, Volume: 28, Issue:5

    Topics: Alkylating Agents; Animals; Carmustine; Cell Line, Tumor; Cyclophosphamide; Dacarbazine; Guanine; Male; Mice; Mice, Transgenic; Mutagenicity Tests; Mutation; O(6)-Methylguanine-DNA Methyltransferase; Temozolomide; Transfection

2007
The Fanconi anemia (FA) pathway confers glioma resistance to DNA alkylating agents.
    Journal of molecular medicine (Berlin, Germany), 2007, Volume: 85, Issue:5

    Topics: Antineoplastic Agents, Alkylating; Brain Neoplasms; Carmustine; Cell Line, Tumor; Curcumin; Dacarbazine; DNA Modification Methylases; DNA Repair; DNA Repair Enzymes; Dose-Response Relationship, Drug; Drug Resistance, Neoplasm; Enzyme Inhibitors; Fanconi Anemia Complementation Group D2 Protein; Fanconi Anemia Complementation Group F Protein; Fanconi Anemia Complementation Group Proteins; Glioma; Guanine; Humans; Protein Processing, Post-Translational; RNA Interference; RNA, Small Interfering; Temozolomide; Time Factors; Transfection; Tumor Suppressor Proteins; Ubiquitins

2007
Stable differentiation and clonality of murine long-term hematopoiesis after extended reduced-intensity selection for MGMT P140K transgene expression.
    Blood, 2007, Sep-15, Volume: 110, Issue:6

    Topics: Animals; Antineoplastic Agents; Antineoplastic Agents, Alkylating; Bone Marrow Cells; Bone Marrow Transplantation; Carmustine; Cell Differentiation; Genetic Therapy; Guanine; Hematopoiesis; Mice; Mice, Inbred C57BL; Mice, Transgenic; Myeloid Cells; O(6)-Methylguanine-DNA Methyltransferase; Stem Cells; Terminal Repeat Sequences; Transduction, Genetic; Transplantation, Homologous

2007
Carmustine-resistant cancer cells are sensitized to temozolomide as a result of enhanced mismatch repair during the development of carmustine resistance.
    Molecular pharmacology, 2008, Volume: 74, Issue:1

    Topics: Antineoplastic Agents, Alkylating; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Cadmium Chloride; Carmustine; Cell Line, Tumor; Cell Proliferation; Comet Assay; Dacarbazine; DNA Mismatch Repair; Dose-Response Relationship, Drug; Drug Resistance, Neoplasm; Guanine; Humans; Hydroxylamines; Nimustine; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Temozolomide

2008
Heterogeneity of human glioblastoma: glutathione-S-transferase and methylguanine-methyltransferase.
    Cancer investigation, 2008, Volume: 26, Issue:6

    Topics: Alkylating Agents; Brain Neoplasms; Carmustine; Cell Line, Tumor; Cell Proliferation; DNA Methylation; DNA Modification Methylases; DNA Repair Enzymes; DNA Replication; Dose-Response Relationship, Drug; Enzyme Inhibitors; Ethacrynic Acid; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Glioblastoma; Glutathione S-Transferase pi; Glutathione Transferase; Guanine; Humans; Melphalan; Promoter Regions, Genetic; Tumor Suppressor Proteins

2008
Methylguanine DNA methyltransferase-mediated drug resistance-based selective enrichment and engraftment of transplanted stem cells in skeletal muscle.
    Stem cells (Dayton, Ohio), 2009, Volume: 27, Issue:5

    Topics: Animals; Animals, Genetically Modified; Antigens, CD34; Carmustine; Cell Differentiation; Cell Separation; Cell Survival; Drug Resistance; Guanine; Humans; Mice; Muscle Fibers, Skeletal; Muscle, Skeletal; Myoblasts; O(6)-Methylguanine-DNA Methyltransferase; Regeneration; Retroviridae; Stem Cell Transplantation; Transduction, Genetic

2009
In vivo selection of hematopoietic progenitor cells and temozolomide dose intensification in rhesus macaques through lentiviral transduction with a drug resistance gene.
    The Journal of clinical investigation, 2009, Volume: 119, Issue:7

    Topics: Animals; Antineoplastic Agents, Alkylating; Carmustine; Dacarbazine; Genetic Therapy; Genetic Vectors; Guanine; Hematopoietic Stem Cell Transplantation; Homeodomain Proteins; Lentivirus; Macaca mulatta; O(6)-Methylguanine-DNA Methyltransferase; Temozolomide

2009
Effect of O6-chloroethylguanine DNA lesions on the kinetics and mechanism of micronucleus induction in vivo.
    Environmental and molecular mutagenesis, 2010, Volume: 51, Issue:3

    Topics: Animals; Antineoplastic Agents, Alkylating; Carmustine; DNA Damage; Dose-Response Relationship, Drug; Enzyme Inhibitors; Erythrocytes; Guanine; Kinetics; Male; Mice; Mice, Inbred BALB C; Micronuclei, Chromosome-Defective; O(6)-Methylguanine-DNA Methyltransferase; Toxicity Tests

2010
Efficient and stable MGMT-mediated selection of long-term repopulating stem cells in nonhuman primates.
    The Journal of clinical investigation, 2010, Volume: 120, Issue:7

    Topics: Animals; Carmustine; Genetic Therapy; Guanine; Hematopoietic Stem Cell Transplantation; Macaca nemestrina; Male; O(6)-Methylguanine-DNA Methyltransferase; Papio; Retroviridae; Stem Cells; Transgenes

2010
Cationic core-shell nanoparticles with carmustine contained within O⁶-benzylguanine shell for glioma therapy.
    Biomaterials, 2013, Volume: 34, Issue:35

    Topics: Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Carmustine; Cations; Cell Line, Tumor; Chemical Phenomena; Disease Models, Animal; Drug Delivery Systems; Female; Glioblastoma; Guanine; Magnetic Resonance Imaging; Male; Nanoparticles; Rats; Rats, Inbred F344

2013
iRGD-mediated core-shell nanoparticles loading carmustine and O
    Journal of drug targeting, 2017, Volume: 25, Issue:3

    Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Carmustine; Cell Line, Tumor; Disease Models, Animal; Drug Carriers; Glioma; Guanine; Humans; Male; Mice; Mice, Inbred BALB C; Mice, Inbred ICR; Mice, Nude; Nanoparticles; Oligopeptides; Tumor Microenvironment

2017