carmustine has been researched along with lomustine in 235 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 172 (73.19) | 18.7374 |
| 1990's | 31 (13.19) | 18.2507 |
| 2000's | 17 (7.23) | 29.6817 |
| 2010's | 13 (5.53) | 24.3611 |
| 2020's | 2 (0.85) | 2.80 |
| Authors | Studies |
|---|---|
| Clayton, SD; Frye, JL; Johnston, TP; Krauth, CA; McCaleb, GS; Montgomery, JA | 1 |
| Johnston, TP; Laster, WR; Mayo, JG; McCaleb, GS; Montgomery, JA | 1 |
| Dolan, ME; Weinkam, RJ | 1 |
| Levin, VA | 1 |
| Hansch, C; Jow, PY; Leo, A; Montgomery, JA; Schmidt, C | 1 |
| González-Díaz, H; Orallo, F; Quezada, E; Santana, L; Uriarte, E; Viña, D; Yáñez, M | 1 |
| Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
| Benfenati, E; Raska, I; Toropov, AA; Toropova, AP | 1 |
| García-Mera, X; González-Díaz, H; Prado-Prado, FJ | 1 |
| Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ | 1 |
| Bleehen, NM; Twentyman, PR | 2 |
| Bruntsch, U | 1 |
| Twentyman, PR | 1 |
| Murphy, GP; Sufrin, G | 1 |
| Rao, AP; Rao, PN | 1 |
| Walker, MD | 2 |
| Bhuyan, BK; Day, KJ; Fraser, TJ | 1 |
| Fox, P; Green, D; Nagourney, R; Panasci, LC; Schein, PS | 1 |
| Kann, HE | 1 |
| Ewig, RA; Kohn, KW | 2 |
| Bradley, MO; Erickson, LC; Kohn, KW | 1 |
| Eisenbrand, G; Fiebig, HH; Zeller, WJ | 1 |
| Moertel, CG | 3 |
| Bono, VH | 1 |
| Livingston, RB | 1 |
| Boldrey, EB; Drafts, D; Enot, KJ; Gutin, P; Levin, VA; Wilson, CB | 1 |
| Campbell, RJ; Laws, ER; Saez, RJ | 1 |
| Schmidt, CG | 1 |
| Bonadonna, G; Brambilla, C; Monfardini, S; Morello, G; Solero, CL; Vaghi, A; Valagussa, P | 2 |
| Hassoun, J; Paillas, JE; Pellet, W; Peragut, JC; Prince, MA | 1 |
| Burgert, EO; Cuttner, J; Degnan, T; Del Duca, V; Falkson, G; Freeman, A; Hakami, N; Holland, J; Koch, K; Kung, FH; Lanzkowsky, P; Leone, LA; Nawabi, IU; Nythan, WL; Pajak, TF; Patterson, RB; Pluess, H; Ruymann, F | 1 |
| Auletta, AE; Martz, AG; Parmar, AS | 1 |
| Knerich, R; Paoletti, P; Robustelli della Cuna, G; Strada, MR | 1 |
| Albert, ED; Bender-Gotze, C; Grosse-Wilde, H; Kolb, HJ; Lieven, HV; Thiel, E; Wundisch, GF | 1 |
| McIntyre, OR | 1 |
| Bistoni, F; Bonmassar, E; Frati, L; Goldin, A; Marconi, P; Pitzurra, M; Spreafico, F | 1 |
| Baldini, M; Knerich, R; Paoletti, P; Princi, L | 1 |
| Barlogie, B; Drewinko, B; Freireich, EJ | 1 |
| Corbett, TH; Griswold, DP; Schabel, FM; Venditti, JM; Wolpert, MK | 1 |
| Lin, HS; Weinkam, RJ | 2 |
| Deen, DF; Wheeler, KT; Williams, ME | 1 |
| Begleiter, A; Goldenberg, GJ; Lam, HP | 1 |
| Fumagalli, R; Paoletti, P; Pezzotta, S; Weiss, JF | 1 |
| Koós, R; Krauze, I; Péter, A; Schuler, D | 1 |
| Fumagalli, R; Paoletti, P; Pezzotta, S; Racca, AR | 2 |
| Goldin, A | 1 |
| Bono, VH; Louie, AC; Muggia, FM; Turrisi, AT | 1 |
| Levin, VA; Wilson, CB | 3 |
| Freeman-Dove, MA; Kabra, PA; Levin, VA | 1 |
| Byrd, A; Finn, A; Levin, VA; Stearns, J; Weinkam, RJ | 1 |
| Comis, RL | 1 |
| Hill, G; Johnson, RO; Krementz, E; Metter, G; Wilson, W | 1 |
| Carbone, PP; Costello, W | 1 |
| Marsh, JC | 1 |
| Schabel, FM | 1 |
| Ahmann, DL | 1 |
| Wolf, J | 1 |
| Bartolucci, A; Dorfman, RF; Durant, JR; Gams, RA; Velez-Garcia, E | 1 |
| Salmon, SE | 2 |
| Cruz, AB; Davis, HL; Fletcher, WS; Golomb, FM; Grage, T; Hill, GJ; Johnson, RO; Metter, G; Wilson, WL | 1 |
| Oliverio, VT | 1 |
| Kohn, KW | 1 |
| Aranha, GV; Grage, TB | 1 |
| Wilson, CB | 1 |
| Brundrett, RB; Colvin, M; Cowens, W; Jardine, I; Ludlum, DB | 1 |
| Wasserman, TH | 1 |
| Hilton, J; Walker, MD | 1 |
| Balis, E; Brisman, R; Chang, C; Duffy, P; Housepian, EM | 1 |
| Slavik, M | 1 |
| Carter, RD; Fletcher, WS; Golomb, FM; Grage, TB; Hill, GJ; Krementz, ET; Metter, GE; Minton, JP; Sparks, FC | 1 |
| Chuang, RY; Keller, P; Laszlo, J | 1 |
| Carter, SK; Slavik, M; Wasserman, TH | 1 |
| James, R; Johnston, TP; Kirk, MC; McCaleb, GS; Montgomery, JA | 1 |
| Epstein, EH; Zackheim, HS | 1 |
| Carter, SK | 1 |
| Drewinko, B; Gottlieb, JA; Loo, TL | 1 |
| Camus, P; Coudert, B; Foucher, P; Jeannin, L; Lombard, JN; Massin, F; Reybet-Degat, O | 1 |
| Aziz Rani, A; Chudahman, M; Dharmika, D; Ismail Ali, A; Simadibrata, R | 1 |
| Dolan, ME; Mitchell, RB; Moschel, RC; Mummert, C; Pegg, AE | 1 |
| Matthay, RA; Twohig, KJ | 1 |
| Glover, DJ | 1 |
| Dolan, ME; Mitchell, RB; Moschel, RC | 1 |
| Bizzari, JP; Fillastre, JP; Hemet, J; Laquerriere, A; Paraire, M; Paresy, M; Raguenez-Viotte, G | 1 |
| Wallen, CA; Wheeler, KT; Wong, KH | 2 |
| Gattamaneni, HR; Ogilvy-Stuart, AL; Shalet, SM | 1 |
| Davis, RL; Gutin, PH; Hannigan, J; Levin, VA; Silver, P; Wara, WM; Wilson, CB | 1 |
| Durand, RE | 1 |
| Bradford, R; Darling, JL; Sier, N; Thomas, DG | 1 |
| Bradford, R; Darling, JL; Thomas, DG | 1 |
| Bizzari, JP; Deloffre, P; Etienne, MC; Fischel, JL; Formento, P; Frenay, M; Gioanni, J; Milano, G | 1 |
| Brajtburg, J; Elberg, S; Medoff, G; Schechtman, KB | 1 |
| Assietti, R; Butti, G; Gaetani, P; Knerich, R; Paoletti, P | 1 |
| Anderson, SP; Briscoe, WT; May, HE | 1 |
| Brent, TP; Smith, DG | 1 |
| Gerson, SL | 1 |
| Clayton, PE; Jones, PH; Price, DA; Shalet, SM | 1 |
| Clyde, C; Dolan, ME; Erickson, LC; Hora, NK; Norbeck, L; Pegg, AE | 1 |
| Bodell, WJ; Doane-Setzer, P; Evans, CG; Smith, MT; Tokuda, K | 1 |
| Dive, C; Watson, JV; Workman, P | 1 |
| Giles, RC; Harrison, SD; Mann, DM | 1 |
| Kapp, JP; Vance, RB | 1 |
| Davis, RL; Gutin, PH; Levin, VA; Nutik, S; Resser, KJ; Vestnys, P; Wara, WM; Wilson, CB; Yatsko, K | 1 |
| Bricolo, A; Della Corte, V; Gerosa, MA; Licata, C; Marcon, C; Rosenblum, ML; Stevanoni, G; Tridente, G | 1 |
| Brunner, K; Coleman, M; Cooper, MR; Cornwell, GG; Glowienka, LP; Henderson, E; Kochwa, S; McIntyre, OR; Pajak, TF; Rafla, S | 1 |
| Holden, SA; Rose, CM; Teicher, BA | 1 |
| Cassady, JR; Hughes, EN; Loeffler, JS; Sallan, SE; Shillito, J; Tarbell, NJ | 1 |
| Campbell, RH; Clayton, PE; Price, DA; Shalet, SM | 1 |
| Morimoto, RI; Schaefer, EL; Seidenfeld, J; Theodorakis, NG | 1 |
| El-Yazigi, A; Martin, CR | 1 |
| Brajtburg, J; Elberg, S; Kobayashi, GS; Medoff, G | 1 |
| Adamson, DJ; Brockman, RW; Elliott, RD; Montgomery, JA; Riordan, JM; Shaddix, SC; Thomas, HJ | 1 |
| Cairncross, JG; Macdonald, DR | 1 |
| Kamiya, S | 1 |
| Phillips, GL; Reece, DE | 1 |
| Denkel, E; Eisenbrand, G; Müller, N; Sterzel, W | 1 |
| Ludlum, DB | 1 |
| Godlewski, A; Szczech, J | 1 |
| Dean, PN; Deen, DF; Gray, JW; Linfoot, PA; Marton, LJ | 1 |
| Carpenter, L; Hill, GJ; Hill, HZ; Lea, MA; Luke, A; Martinson, CF; Velazquez, O | 1 |
| Kovatch, RM; Lijinsky, W; Singer, SS | 1 |
| Powell, SR; Puglia, CD | 1 |
| Chessa, A; Desogus, A; Floris, C; Muggiano, A; Sulis, E; Tedde, A; Turno, R | 1 |
| Bosanquet, AG | 1 |
| Ozhiganov, EL; Platinskiĭ, LV; Sokolova, VD | 1 |
| Mulcahy, RT; Siemann, DW | 2 |
| Adams, K; Peacock, JH; Stephens, TC | 1 |
| Bleehen, NM; Honess, DJ | 1 |
| Baril, B; Baril, E; Laszlo, J | 1 |
| Brugerie, E; Huong, TH; Lheritier, J; Pouillart, R | 1 |
| Kessinger, A | 1 |
| Huang, AT; Lucas, VS; Pickett, NJ; Seigler, HF | 1 |
| Gamsu, G; Putman, CE; Sostman, HD | 1 |
| Bloomfield, CD; Coleman, M; Glicksman, AS; Glidewell, OJ; Gottlieb, AJ; Holland, JF; Nissen, NI; Pajak, TF; Rafla, S; Stutzman, L; Vinciguerra, V | 1 |
| Heim, ME; Queisser, W | 1 |
| Rice, LS; Shannon, WM; Suling, WJ | 1 |
| Wakui, A | 1 |
| Glatte, P; Osieka, R; Pannenbäcker, R; Schmidt, CG | 1 |
| deKernion, JB; Lindner, A | 1 |
| Adams, GE | 1 |
| Lee, FY; Workman, P | 1 |
| Bernardo, G; Butti, G; Cuzzoni, Q; Knerich, R; Paoletti, P; Robustelli della Cuna, G | 1 |
| Erickson, LC; Zlotogorski, C | 1 |
| Biron, P; Dutou, L; Ehrsam, A; Hervé, P; Le Mevel, A; Philip, I; Philip, T; Philippe, N; Plouvier, E; Souillet, G | 1 |
| Hill, GJ; Hill, HZ; Krementz, ET | 1 |
| Preussmann, R | 1 |
| Fingert, HJ; Hochberg, FH | 1 |
| Deen, DF; Marton, LJ; Oredsson, SM | 1 |
| Kann, HE; Petkas, A; Schott, MA | 1 |
| Hoth, D; Macdonald, JS; Schein, PS | 1 |
| Mutzner, F | 1 |
| Bartosek, I; Cattaneo, MT; Russo, RG | 1 |
| Bernaudin, JF; Cordonnier, C; Lange, F; Mital, P; Rochant, H; Vernant, JP | 1 |
| Dieckman, J; Medoff, G; Valeriote, F | 1 |
| Oguro, M; Takenaga, K; Yanagawa, T | 1 |
| Brannan, TS; Maker, HS; Weiss, C | 1 |
| Erickson, LC; Kohn, KW; Sariban, E | 1 |
| Siemann, DW; Wallen, CA; Wheeler, KT; Wolf, KL | 1 |
| Shapiro, WR | 1 |
| Issell, BF; Weiss, RB | 1 |
| Robak, T | 1 |
| Potter, DW; Reed, DJ | 1 |
| Gropp, C; Havemann, K | 1 |
| Brunner, K; Cuttner, J; Falkson, G; Hansen, HH; Holland, JF; Nissen, NI; Pajak, TF; Selawry, OS; Spurr, CL | 1 |
| Levin, VA; Vestnys, PS; Wilson, CB | 1 |
| Siemann, DW | 1 |
| Chin, HW; Maruyama, Y; Muir, W; Young, AB | 1 |
| Deen, DF; Weinkam, RJ | 1 |
| Buoncristiani, P; Casotto, A | 1 |
| Brunner, K; Cooper, MR; Cornwell, GG; Cuttner, J; Glowienka, LP; Haurani, FI; Henderson, E; Kochwa, S; Kyle, RA; McIntyre, OR; Pajak, TF; Rafla, S; Silver, RT | 1 |
| Kohn, KW; Ludlum, DB; Tong, WP | 1 |
| Gibson, NW; Hickman, JA | 1 |
| Gombar, CT; Ludlum, DB; Tong, WP | 1 |
| Chauhan, SM; Lown, JW | 1 |
| Blackstock, SC; Cheung, LK; Loo, TL; Smith, RG | 1 |
| Baldwin, DS; Feiner, HD; Gallo, GR; Lieberman, A; Schacht, RG | 1 |
| Eisenbrand, G; Habs, M | 1 |
| Gordy, DD; Murray, JL; Robertson, DM; Wilkinson, CP | 1 |
| Babson, JR; Brodie, AE; Reed, DJ | 1 |
| Finn, A; Kane, JP; Levin, VA; Weinkam, RJ | 1 |
| Smuckler, EA; Zackheim, HS | 1 |
| Finkel, JM; Hill, DL; Kari, P; McConnell, WR | 1 |
| Cenci, E; Perito, S; Sbaraglia, G; Vecchiarelli, A | 1 |
| Ardiet, C; Lind, MJ | 1 |
| Gazdar, AF; Ghosh, BC; Ihde, DC; Johnson, BE; Linnoila, RI; Minna, JD; Mulshine, JL; Oie, HK; Pass, HI; Phelps, R; Russell, EK; Shaw, GL; Steinberg, SM | 1 |
| Kohda, K; Terashima, I | 1 |
| Mennel, HD; Ruschoff, J; Schlegel, J; Stumm, G | 1 |
| Allison, RR; Barry, T; Schulsinger, A; Shin, KH; Vongtama, V | 1 |
| Adler, ID; Ehling, UH; Favor, J; Neuhäuser-Klaus, A | 1 |
| Ahmed, MM; Albores-Saavedra, J; Delgado, R; Fruitwala, MM; Kokkinakis, DM; Mohiuddin, M | 1 |
| Golovinsky, E; Gugova, R; Staleva, L; Venkov, P; Waltscheva, L | 1 |
| Gundersen, S; Lote, K; Watne, K | 1 |
| Bass, G; Bloxham, D; Gandhi, MK; Jestice, K; Marcus, RE; Scott, MA | 1 |
| Devereux, S; Goldstone, AH; Gregory, W; Hancock, B; Harrison, CN; Hoskin, P; Hudson, GV; Linch, DC; MacMillan, AK; Milligan, D; Newland, AC; Winfield, D | 1 |
| Curran, WJ; Kramer, S; Leibel, S; Nelson, DF; Prados, MD; Scott, C | 1 |
| Penketh, PG; Sartorelli, AC; Shyam, K | 1 |
| Weller, M; Winter, S | 1 |
| Boiardi, A; Broggi, G; Eoli, M; Pozzi, A; Salmaggi, A; Silvani, A | 1 |
| Hung, CF | 1 |
| Bardenheuer, W; Flasshove, M; Jansen, M; Moritz, T; Seeber, S; Sorg, UR | 1 |
| Blume, KG; Chao, NS; Horning, SJ; Johnston, LJ; Long, GD; Negrin, RS; Shizuru, JA; Stockerl-Goldstein, KE; Stuart, MJ; Wong, RM | 1 |
| Mo, H; Ou, G; Qin, D | 1 |
| Eisen, TG; Lens, MB | 1 |
| Jung, SM; Liau, CT; Tseng, CK; Wei, KC | 1 |
| Berrak, S; Koontz Webb, SE; Wolff, JE; Zhang, M | 1 |
| Ansell, S; Arndt, C; Buckner, J; Christianson, T; Galanis, E; Gill, P; Litzow, M; Moynihan, T | 1 |
| Kobiakov, GL | 1 |
| Deray, G; Isnard-Bagnis, C; Janus, N; Karie, S; Launay-Vacher, V | 1 |
| Amarasingh, S; Macleod, MR; Whittle, IR | 1 |
| Kartashev, AV; Vinogradov, VM | 1 |
| Filatova, LV; Gershanovich, ML | 1 |
| Nishikawa, R | 1 |
| Kim, JH; Kim, ST; Kim, WS; Kong, DS; Kwon, KH; Lee, JI; Lim, DH; Nam, DH; Park, K; Suh, YL | 1 |
| Audrain, O; Carsin, B; Gedouin, D; Hamlat, A; Lecouillard, I; Lesimple, T; Louvel, G; Mesbah, H; Quillien, V; Riffaud, L; Vauleon, E | 1 |
| Ahmed, AB; Bruserud, O; Hatfield, KJ; Kittang, AO; Reikvam, H; Sjo, M; Tvedt, TH | 1 |
| Brodbelt, A; Mallucci, C; Pizer, B; Salehzadeh, A | 1 |
| Alexander, BM; Beroukhim, R; Doherty, L; Hempfling, K; Huang, RY; LaFrankie, D; Lee, EQ; Nayak, L; Norden, AD; Rahman, R; Rai, A; Reardon, DA; Rifenburg, J; Rinne, ML; Ruland, S; Wen, PY | 1 |
| Abuali, I; Grossman, SA; Lu, Y; Strowd, RE; Ye, X | 1 |
| Gore, A; Gupta, A; Jain, R; Jeevangi, N; Kannan, S; Khattry, N; Nair, R; Saikia, T; Thippeswamy, R | 1 |
| Ardeshna, KM; Foley, M; Kothari, J; Lambert, J; Linch, DC; Mackenzie, S; Morris, E; Peggs, KS; Thomson, K; Virchis, AE | 1 |
| Bettarello, G; Costa, LJM; da Matta Abreu, M; Dos Santos, KB; Hallack Neto, AE; Mayrink, GTC; Mota, MA; Pereira, J; Ribeiro, LC | 1 |
| Kelsey, P; Kirkland, K; Lambert, J; Malladi, R; Morley, N; Paul, R; Pearce, R; Peniket, A; Perry, J; Snowden, JA | 1 |
| Awortwe, C; Cascorbi, I; Kaehler, M; Majchrzak-Celińska, A; Nagel, I; Radtke, L; Sebens, S; Vater, I | 1 |
28 review(s) available for carmustine and lomustine
| Article | Year |
|---|---|
Review of mechanism of action studies of the nitrosoureas.
Topics: Alkylating Agents; Animals; Bone Marrow; Bone Marrow Cells; Carmustine; Cell Division; Cell Survival; DNA; DNA, Neoplasm; Ethyl Chloride; Lomustine; Mice; NAD+ Nucleosidase; Neoplasms, Experimental; Nitrosourea Compounds; Protein Biosynthesis; RNA; Semustine; Streptozocin | 1976 |
Current concepts in cancer. Multiple myeloma.
Topics: Antineoplastic Agents; Carmustine; Cyclophosphamide; Drug Therapy, Combination; Humans; Immunoglobulins; Lomustine; Melphalan; Multiple Myeloma; Neoplasm Staging; Plasmapheresis; Prednisone; Risk; Sodium Fluoride; Uremia | 1979 |
DTIC (NSC-45388) in malignant melanoma: a perspective.
Topics: Animals; Antineoplastic Agents; Carmustine; Clinical Trials as Topic; Dacarbazine; Drug Evaluation; Drug Therapy, Combination; Humans; Lomustine; Melanoma; Mice; Neoplasm Metastasis; Nitrosourea Compounds; Remission, Spontaneous; Triazenes | 1976 |
The effects of cancer chemotherapeutic agents on normal hematopoietic precursor cells: a review.
Topics: Alkylating Agents; Animals; Antibiotics, Antineoplastic; Antimetabolites, Antineoplastic; Antineoplastic Agents; Asparaginase; Benzamides; Busulfan; Carmustine; Cisplatin; Cyclophosphamide; Cytarabine; Drug Evaluation, Preclinical; Erythrocytes; Fluorouracil; Hematopoietic Stem Cells; Humans; Hydroxyurea; Lomustine; Methotrexate; Nitrogen Mustard Compounds; Spleen; Vinca Alkaloids | 1976 |
Nitrosoureas: a review of experimental antitumor activity.
Topics: Animals; Carmustine; Colonic Neoplasms; Drug Evaluation, Preclinical; Drug Resistance; Drug Therapy, Combination; Leukemia L1210; Lomustine; Lung Neoplasms; Mammary Neoplasms, Experimental; Melanoma; Methylnitronitrosoguanidine; Methylnitrosourea; Mice; Neoplasms, Experimental; Nitrosourea Compounds; Semustine | 1976 |
Chemotherapy: the agents in current use.
Topics: Antineoplastic Agents; Brain Neoplasms; Carmustine; Dacarbazine; Drug Therapy, Combination; Glioma; Humans; Lomustine; Medulloblastoma; Methotrexate; Nitrogen Mustard Compounds; Procarbazine; Semustine; Teniposide; Vincristine | 1975 |
Clinical comparison of the nitrosoureas.
Topics: Animals; Antineoplastic Agents; Brain Neoplasms; Breast Neoplasms; Carmustine; Chemical Phenomena; Chemistry; Colonic Neoplasms; Drug Therapy, Combination; Hodgkin Disease; Humans; Lomustine; Lung Neoplasms; Lymphoma; Melanoma; Methylnitrosourea; Mice; Neoplasms, Experimental; Nitrosourea Compounds; Rectal Neoplasms | 1975 |
[Nitrosourea-induced lung diseases].
Topics: Adult; Brain Neoplasms; Carmustine; Child; Drug Therapy, Combination; Female; Humans; Iatrogenic Disease; Lomustine; Lung; Lung Diseases; Nitrosourea Compounds; Pneumonia; Prognosis; Pulmonary Fibrosis; Risk Factors; Semustine | 1992 |
Pulmonary effects of cytotoxic agents other than bleomycin.
Topics: Antineoplastic Agents; Bleomycin; Busulfan; Carmustine; Cyclophosphamide; Humans; Lomustine; Methotrexate; Mitomycins; Pulmonary Fibrosis; Vinblastine; Vindesine | 1990 |
Clinical studies of autologous bone marrow transplantation in Hodgkin's disease.
Topics: Alkylating Agents; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Bone Marrow; Bone Marrow Transplantation; Carmustine; Cell Separation; Combined Modality Therapy; Cyclophosphamide; Cytarabine; Drug Resistance; Etoposide; Hodgkin Disease; Humans; Lomustine; Pulmonary Fibrosis; Risk; Thioguanine; Transplantation, Autologous; Whole-Body Irradiation | 1986 |
DNA adducts and DNA damage by antineoplastic and carcinogenic N-nitrosocompounds.
Topics: Alkylation; Animals; Antineoplastic Agents; Carcinogens; Carmustine; Chemical Phenomena; Chemistry; DNA; Ethylnitrosourea; Liver Neoplasms; Lomustine; Mammary Neoplasms, Experimental; Nitrosourea Compounds; Nucleic Acid Conformation | 1986 |
Stability of solutions of antineoplastic agents during preparation and storage for in vitro assays. General considerations, the nitrosoureas and alkylating agents.
Topics: Alkylation; Antineoplastic Agents; Carmustine; Chlorambucil; Colony-Forming Units Assay; Cyclophosphamide; Drug Storage; Hydrogen-Ion Concentration; Lomustine; Mathematics; Melphalan; Nimustine; Nitrosourea Compounds; Solutions; Temperature; Tumor Stem Cell Assay | 1985 |
[Chemotherapy of cancer of the large intestine].
Topics: Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Carmustine; Colonic Neoplasms; Drug Evaluation; Fluorouracil; Humans; Lomustine; Melphalan; Methotrexate; Rectal Neoplasms; Semustine; Vincristine | 1985 |
High dose chemotherapy with autologous bone marrow rescue for high grade gliomas of the brain: a potential for improvement in therapeutic results.
Topics: Antineoplastic Combined Chemotherapy Protocols; Bone Marrow Transplantation; Brain Neoplasms; Carmustine; Combined Modality Therapy; Etoposide; Glioblastoma; Glioma; Humans; Lomustine; Teniposide | 1984 |
Review: diagnosis of chemotherapy lung.
Topics: Adult; Aged; Antibiotics, Antineoplastic; Antineoplastic Agents; Bleomycin; Busulfan; Carmustine; Cyclophosphamide; Female; Humans; Lomustine; Lung Diseases; Lung Neoplasms; Male; Mercaptopurine; Methotrexate; Middle Aged; Pulmonary Fibrosis; Radiography | 1981 |
Chemotherapy in alimentary tract malignomas.
Topics: Antibiotics, Antineoplastic; Antineoplastic Agents; Carmustine; Colonic Neoplasms; Cytarabine; Doxorubicin; Drug Therapy, Combination; Female; Fluorouracil; Humans; Lomustine; Male; Methotrexate; Mitomycin; Mitomycins; Rectal Neoplasms; Semustine; Stomach Neoplasms; Streptozocin; Tegafur; Vincristine | 1981 |
[Cancer chemotherapy with special reference to pharmacokinetics of nitrosoureas].
Topics: Carmustine; Humans; Kinetics; Lomustine; Neoplasms; Nimustine; Nitrosourea Compounds; Semustine; Solubility; Streptozocin | 1982 |
Chemotherapy of hormonally unresponsive prostatic carcinoma.
Topics: Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Carcinoma; Carmustine; Cisplatin; Clinical Trials as Topic; Cyclophosphamide; Diethylstilbestrol; Doxorubicin; Estramustine; Fluorouracil; Humans; Imidazoles; Lomustine; Male; Methotrexate; Mitomycin; Mitomycins; Prednimustine; Prednisone; Procarbazine; Prostatic Neoplasms; Random Allocation; Streptozocin; Vincristine | 1984 |
Carcinogenic N-nitroso compounds and their environmental significance.
Topics: Alkylation; Animals; Brain Neoplasms; Carcinogens; Carcinogens, Environmental; Carmustine; Dimethylnitrosamine; Dose-Response Relationship, Drug; Environmental Exposure; Food Analysis; Food Contamination; Humans; Hydroxylation; Leukemia; Life Style; Liver; Lomustine; Mice; Neoplasms; Nitrosamines; Nitroso Compounds; Rats; Risk; Smoking | 1984 |
Treatment of neuroectodermal brain tumors.
Topics: Adult; Age Factors; Aged; Antineoplastic Agents; Astrocytoma; Blood-Brain Barrier; Brain Neoplasms; Carmustine; Clinical Trials as Topic; Drug Therapy, Combination; Glioma; Humans; Lomustine; Middle Aged; Mitotic Index; Oligodendroglioma; Prospective Studies; Random Allocation; Semustine | 1982 |
The nitrosoureas: carmustine (BCNU) and lomustine (CCNU).
Topics: Bone Marrow; Brain Neoplasms; Carmustine; Drug Therapy, Combination; Gastrointestinal Neoplasms; Hodgkin Disease; Humans; Kidney; Lomustine; Lung; Lung Neoplasms; Lymphoma; Melanoma; Multiple Myeloma; Neoplasms; Nitrosourea Compounds | 1982 |
Potentiation of chemotherapy by hypoxic cell radiation sensitizers--a review.
Topics: Anaerobiosis; Animals; Antineoplastic Agents; Carmustine; Cyclophosphamide; Drug Synergism; Lomustine; Mice; Misonidazole; Neoplasms, Experimental; Radiation-Sensitizing Agents | 1982 |
Pharmacokinetics of alkylating agents.
Topics: Alkylating Agents; Carmustine; Chlorambucil; Cyclophosphamide; Humans; Ifosfamide; Lomustine; Melphalan; Neoplasms; Nitrosourea Compounds; Organophosphorus Compounds; Thiotepa | 1993 |
Systemic chemotherapy in the treatment of malignant melanoma.
Topics: Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Carmustine; Cisplatin; Clinical Trials as Topic; Cyclophosphamide; Dacarbazine; Humans; Lomustine; Melanoma; Neoplasm Metastasis; Skin Neoplasms; Tamoxifen; Treatment Outcome; Vincristine | 2003 |
[Clinical significance of mustoforan in management of malignant glioma].
Topics: Adult; Aged; Antineoplastic Agents; Antineoplastic Agents, Alkylating; Astrocytoma; Blood-Brain Barrier; Brain Neoplasms; Carmustine; Clinical Trials as Topic; Disease-Free Survival; Female; Glioblastoma; Glioma; Humans; Lomustine; Magnetic Resonance Imaging; Male; Middle Aged; Neoplasm, Residual; Nitrosourea Compounds; Oligodendroglioma; Organophosphorus Compounds; Semustine; Survival Analysis; Treatment Outcome | 2007 |
What is the translational efficacy of chemotherapeutic drug research in neuro-oncology? A systematic review and meta-analysis of the efficacy of BCNU and CCNU in animal models of glioma.
Topics: Animals; Antineoplastic Agents, Alkylating; Carmustine; Disease Models, Animal; Drug Evaluation; Glioma; Humans; Lomustine; Meta-Analysis as Topic | 2009 |
[Treatment of glioma with temozolomide].
Topics: Aged; Aged, 80 and over; Antineoplastic Agents, Alkylating; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Carmustine; Dacarbazine; DNA Damage; Glioblastoma; Humans; Leukemia, Myeloid, Acute; Lomustine; Myelodysplastic Syndromes; Neoplasms, Second Primary; O(6)-Methylguanine-DNA Methyltransferase; Temozolomide | 2009 |
High-dose etoposide in allogeneic stem cell transplantation.
Topics: Adenine Nucleotides; Anthracyclines; Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Arabinonucleosides; Busulfan; Carboplatin; Carmustine; Clinical Trials as Topic; Clofarabine; Cyclophosphamide; Dose Fractionation, Radiation; Drug Administration Schedule; Etoposide; Humans; Ifosfamide; Leukemia; Leukemia, Myeloid, Acute; Lomustine; Mucositis; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Radiotherapy, Adjuvant; Severity of Illness Index; Stem Cell Transplantation; Transplantation Conditioning; Transplantation, Homologous; Whole-Body Irradiation | 2012 |
32 trial(s) available for carmustine and lomustine
| Article | Year |
|---|---|
Chemotherapy: adjuvant to surgery and radiation therapy.
Topics: Antineoplastic Agents; Brain Neoplasms; Carmustine; Clinical Trials as Topic; Fluorouracil; Glioma; Humans; Lomustine; Maryland; Plicamycin; Prospective Studies; Semustine; Vincristine | 1975 |
Nitrosourea combinations in lung cancer.
Topics: Adenocarcinoma; Carcinoma, Small Cell; Carcinoma, Squamous Cell; Carmustine; Clinical Trials as Topic; Cyclophosphamide; Drug Evaluation; Drug Therapy, Combination; Humans; Lomustine; Lung Neoplasms; Methotrexate; Nitrosourea Compounds; Semustine | 1976 |
Controlled study with BCNU vs. CCNU as adjuvant chemotherapy following surgery plus radiotherapy for glioblastoma multiforme.
Topics: Brain Neoplasms; Carmustine; Clinical Trials as Topic; Female; Glioblastoma; Humans; Lomustine; Male; Middle Aged; Nitrosourea Compounds; Radiotherapy, High-Energy; Random Allocation | 1979 |
Vincristine, prednisone and L-asparaginase in the induction of remission in children with acute lymphoblastic leukemia following relapse.
Topics: Adolescent; Adult; Antineoplastic Agents; Asparaginase; Bone Marrow; Brain Neoplasms; Carmustine; Child; Child, Preschool; Cyclophosphamide; Cytarabine; Drug Therapy, Combination; Female; Humans; Infant; Leukemia, Lymphoid; Lomustine; Male; Prednisone; Recurrence; Remission, Spontaneous; Vincristine | 1978 |
Multidisciplinary treatment for central nervous system tumours with nitrosourea compounds.
Topics: Adolescent; Adult; Aged; Brain Neoplasms; Carmustine; Clinical Trials as Topic; Female; Humans; Lomustine; Male; Middle Aged; Neoplasm Metastasis; Nitrosourea Compounds | 1978 |
DTIC (NSC-45388) in malignant melanoma: a perspective.
Topics: Animals; Antineoplastic Agents; Carmustine; Clinical Trials as Topic; Dacarbazine; Drug Evaluation; Drug Therapy, Combination; Humans; Lomustine; Melanoma; Mice; Neoplasm Metastasis; Nitrosourea Compounds; Remission, Spontaneous; Triazenes | 1976 |
Phase I evaluation of DTIC (NSC-45388) and other studies in malignant melanoma in the Central Oncology Group.
Topics: Carmustine; Clinical Trials as Topic; Dacarbazine; Drug Evaluation; Drug Therapy, Combination; Female; Humans; Leukopenia; Lomustine; Male; Melanoma; Middle Aged; Nausea; Sex Factors; Thrombocytopenia; Triazenes; Vincristine; Vomiting | 1976 |
Eastern Cooperative Oncology Group studies with DTIC (NSC-45388).
Topics: Adult; Aged; Carmustine; Clinical Trials as Topic; Dacarbazine; Drug Evaluation; Drug Therapy, Combination; Female; Humans; Lomustine; Male; Melanoma; Middle Aged; Sex Factors; Skin Neoplasms; Triazenes | 1976 |
Nitrosoureas in the management of disseminated malignant melanoma.
Topics: Carmustine; Clinical Trials as Topic; Drug Evaluation; Drug Therapy, Combination; Humans; Lomustine; Melanoma; Nitrosourea Compounds; Semustine | 1976 |
Nitrosoureas as single agents in the treatment of pulmonary cancer.
Topics: Carmustine; Clinical Trials as Topic; Cyclophosphamide; Female; Humans; Lomustine; Lung Neoplasms; Male; Nitrosourea Compounds; Semustine | 1976 |
Southeastern Cancer Study Group trials with nitrosoureas in Hodgkin's disease.
Topics: Administration, Oral; Carmustine; Clinical Trials as Topic; Cyclophosphamide; Drug Evaluation; Drug Therapy, Combination; Hodgkin Disease; Humans; Lomustine; Nitrosourea Compounds; Prednisone; Procarbazine; Semustine; Vinblastine | 1976 |
Nitrosoureas in multiple myeloma.
Topics: Carmustine; Clinical Trials as Topic; Doxorubicin; Drug Evaluation; Drug Therapy, Combination; Humans; Lomustine; Multiple Myeloma; Neoplasm Recurrence, Local; Nitrosourea Compounds; Prednisone; Remission, Spontaneous | 1976 |
Adjuvant nitrosourea therapy for glioblastoma.
Topics: Adolescent; Adult; Aged; Brain Neoplasms; Carmustine; Child; Child, Preschool; Drug Evaluation; Female; Glioma; Humans; Lomustine; Male; Middle Aged; Nitrosourea Compounds; Semustine | 1976 |
DTIC (nsc-45388) and combination therapy for melanoma. I. Studies with DTIC, BCNU (NSC-409962), CCNU (NSC-79037), vincristine (NSC-67574), and hydroxyurea (NSC-32065).
Topics: Adolescent; Adult; Aged; Antineoplastic Agents; Carmustine; Dacarbazine; Drug Therapy, Combination; Humans; Hydroxyurea; Lomustine; Melanoma; Middle Aged; Triazenes; United States; Vincristine | 1976 |
Superiority of post-radiotherapy adjuvant chemotherapy with CCNU, procarbazine, and vincristine (PCV) over BCNU for anaplastic gliomas: NCOG 6G61 final report.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Carmustine; Combined Modality Therapy; Glioblastoma; Glioma; Humans; Lomustine; Middle Aged; Multicenter Studies as Topic; Procarbazine; Prognosis; Randomized Controlled Trials as Topic; United States; Vincristine | 1990 |
Phase III comparison of BCNU and the combination of procarbazine, CCNU, and vincristine administered after radiotherapy with hydroxyurea for malignant gliomas.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Carmustine; Clinical Trials as Topic; Combined Modality Therapy; Female; Glioblastoma; Glioma; Humans; Hydroxyurea; Lomustine; Male; Middle Aged; Procarbazine; Vincristine | 1985 |
Vincristine and prednisone prolong the survival of patients receiving intravenous or oral melphalan for multiple myeloma: Cancer and Leukemia Group B experience.
Topics: Antineoplastic Combined Chemotherapy Protocols; Carmustine; Clinical Trials as Topic; Drug Administration Schedule; Female; Humans; Lomustine; Male; Melphalan; Middle Aged; Multiple Myeloma; Prednisone; Random Allocation; Vincristine | 1988 |
Chemotherapy and combined modality therapy for Hodgkin's disease: a progress report on Cancer and Leukemia Group B studies.
Topics: Adult; Antineoplastic Agents; Bleomycin; Carmustine; Doxorubicin; Drug Therapy, Combination; Female; Hodgkin Disease; Humans; Lomustine; Male; Prednisone; Procarbazine; Vincristine | 1982 |
Chemotherapy of hormonally unresponsive prostatic carcinoma.
Topics: Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Carcinoma; Carmustine; Cisplatin; Clinical Trials as Topic; Cyclophosphamide; Diethylstilbestrol; Doxorubicin; Estramustine; Fluorouracil; Humans; Imidazoles; Lomustine; Male; Methotrexate; Mitomycin; Mitomycins; Prednimustine; Prednisone; Procarbazine; Prostatic Neoplasms; Random Allocation; Streptozocin; Vincristine | 1984 |
Dimethyl triazeno imidazole carboxamide and combination therapy for melanoma. IV. Late results after complete response to chemotherapy (Central Oncology Group protocols 7130, 7131, and 7131A).
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Carmustine; Clinical Trials as Topic; Dacarbazine; Female; Humans; Hydroxyurea; Lomustine; Male; Melanoma; Middle Aged; Neoplasm Recurrence, Local; Retrospective Studies; Sex Factors; Skin Neoplasms; Soft Tissue Neoplasms; Time Factors; Vincristine | 1984 |
Treatment of neuroectodermal brain tumors.
Topics: Adult; Age Factors; Aged; Antineoplastic Agents; Astrocytoma; Blood-Brain Barrier; Brain Neoplasms; Carmustine; Clinical Trials as Topic; Drug Therapy, Combination; Glioma; Humans; Lomustine; Middle Aged; Mitotic Index; Oligodendroglioma; Prospective Studies; Random Allocation; Semustine | 1982 |
[Use of nitrosourea compounds in cancer chemotherapy].
Topics: Carmustine; Clinical Trials as Topic; Humans; Lomustine; Neoplasms; Nitrosourea Compounds; Semustine | 1982 |
The superiority of CCNU in the treatment of advanced Hodgkin's disease: Cancer and Leukemia Group B Study.
Topics: Adult; Carmustine; Clinical Trials as Topic; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Hodgkin Disease; Humans; Leukopenia; Lomustine; Male; Nausea; Nitrosourea Compounds; Prognosis; Thrombocytopenia; Vomiting | 1981 |
Primary intracranial gliomas: clinical studies and treatment regimens of the Brain Tumor Research Center, University of California, San Francisco, 1977-1979.
Topics: Antineoplastic Agents; Brain Neoplasms; California; Carmustine; Clinical Trials as Topic; Drug Therapy, Combination; Fluorouracil; Follow-Up Studies; Glioma; Humans; Hydroxyurea; Lomustine; Neoplasm Recurrence, Local; Procarbazine; Vincristine | 1981 |
Comparison of oral melphalan, CCNU, and BCNU with and without vincristine and prednisone in the treatment of multiple myeloma. Cancer and Leukemia Group B experience.
Topics: Antineoplastic Agents; Carmustine; Drug Administration Schedule; Drug Therapy, Combination; Female; Humans; Leukopenia; Lomustine; Male; Melphalan; Middle Aged; Multiple Myeloma; Prednisone; Random Allocation; Thrombocytopenia; Vincristine | 1982 |
Correlation of in vitro drug sensitivity testing results with response to chemotherapy and survival: comparison of non-small cell lung cancer and small cell lung cancer.
Topics: Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Non-Small-Cell Lung; Carcinoma, Small Cell; Carmustine; Cisplatin; Combined Modality Therapy; Cyclophosphamide; Doxorubicin; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Etoposide; Evaluation Studies as Topic; Humans; Lomustine; Lung Neoplasms; Mechlorethamine; Methotrexate; Palliative Care; Predictive Value of Tests; Prospective Studies; Specimen Handling; Survival Analysis; Treatment Outcome; Tumor Cells, Cultured; Vincristine | 1996 |
Efficacy and toxicity of a CCNU-containing high-dose chemotherapy regimen followed by autologous hematopoietic cell transplantation in relapsed or refractory Hodgkin's disease.
Topics: Adolescent; Adult; Aged; Antineoplastic Agents, Alkylating; Antineoplastic Combined Chemotherapy Protocols; Carmustine; Child; Cyclophosphamide; Dose-Response Relationship, Drug; Etoposide; Female; Hodgkin Disease; Humans; Lomustine; Lung Diseases, Interstitial; Lymphoma, Non-Hodgkin; Male; Maximum Tolerated Dose; Middle Aged; Salvage Therapy; Stem Cell Transplantation; Survival Rate; Therapeutic Equivalency; Transplantation, Autologous | 2001 |
[Therapeutic effect on glioblastoma of chemotherapy on the basis of brain irradiation].
Topics: Adolescent; Adult; Aged; Antineoplastic Agents, Alkylating; Brain; Brain Neoplasms; Carmustine; Child; Dose-Response Relationship, Radiation; Female; Glioblastoma; Humans; Lomustine; Male; Middle Aged; Survival Analysis; Survival Rate; Treatment Outcome | 2001 |
[Postoperative chemoradiotherapy for cerebral glioblastoma].
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Carmustine; Chemotherapy, Adjuvant; Dose Fractionation, Radiation; Drug Administration Schedule; Female; Glioblastoma; Humans; Immunotherapy; Interleukin-2; Lomustine; Male; Middle Aged; Postoperative Period; Radiotherapy, Adjuvant; Recombinant Proteins; Survival Analysis; Treatment Outcome; Vincristine | 2008 |
Impact of adjuvant chemotherapy for gliomatosis cerebri.
Topics: Adolescent; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Carmustine; Chemotherapy, Adjuvant; Child; Cohort Studies; Combined Modality Therapy; Cranial Irradiation; Dacarbazine; Female; Humans; Lomustine; Male; Middle Aged; Neoplasm Staging; Neoplasms, Neuroepithelial; Neoplasms, Radiation-Induced; Procarbazine; Prognosis; Retrospective Studies; Survival Rate; Temozolomide; Vincristine; Young Adult | 2010 |
The role of temozolomide in the management of patients with newly diagnosed anaplastic astrocytoma: a comparison of survival in the era prior to and following the availability of temozolomide.
Topics: Antineoplastic Combined Chemotherapy Protocols; Astrocytoma; Brain Neoplasms; Carmustine; Dacarbazine; Female; Follow-Up Studies; Humans; Lomustine; Male; Middle Aged; Neoplasm Recurrence, Local; Neoplasm Staging; Procarbazine; Prognosis; Retrospective Studies; Survival Rate; Temozolomide; Vincristine | 2016 |
LEAM versus CBV for conditioning in autologous hematopoietic stem cell transplantation for lymphoma.
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Carmustine; Cyclophosphamide; Doxorubicin; Etoposide; Female; Hematopoietic Stem Cell Transplantation; Humans; Lomustine; Lymphoma; Male; Methotrexate; Prednisolone; Prospective Studies; Transplantation Conditioning; Transplantation, Autologous | 2019 |
178 other study(ies) available for carmustine and lomustine
| Article | Year |
|---|---|
Synthesis of analogues of N-(2-chloroethyl)-N'-(trans-4-methylcyclohexyl)-N-nitrosourea for evaluation as anticancer agents.
Topics: Animals; Antineoplastic Agents; Chemical Phenomena; Chemistry; Isomerism; Leukemia L1210; Mice; Mice, Inbred Strains; Nitrosourea Compounds; Semustine; Structure-Activity Relationship | 1977 |
Inhibition of solid tumors by nitrosoureas. 1. Lewis lung carcinoma.
Topics: Animals; Carcinoma; Leukemia L1210; Lung Neoplasms; Mice; Mice, Inbred Strains; Neoplasms, Experimental; Nitrosourea Compounds; Structure-Activity Relationship; Time Factors | 1977 |
An analysis of 1-(2-chloroethyl)-1-nitrosourea activity at the cellular level.
Topics: Animals; Antineoplastic Agents; Carmustine; Cell Survival; Drug Evaluation, Preclinical; Ethylnitrosourea; Leukemia L1210; Leukemia P388; Lomustine; Mice; Nitrosourea Compounds; Streptozocin; Structure-Activity Relationship | 1983 |
Relationship of octanol/water partition coefficient and molecular weight to rat brain capillary permeability.
Topics: Animals; Blood-Brain Barrier; Brain; Capillary Permeability; Male; Models, Biological; Molecular Weight; Rats; Rats, Inbred F344; Solubility; Structure-Activity Relationship | 1980 |
Antitumor structure-activity relations. Nitrosoureas vs. L-1210 leukemia.
Topics: Animals; Antineoplastic Agents; Leukemia L1210; Mice; Models, Theoretical; Nitrosourea Compounds; Solubility; Structure-Activity Relationship | 1980 |
Quantitative structure-activity relationship and complex network approach to monoamine oxidase A and B inhibitors.
Topics: Computational Biology; Drug Design; Humans; Isoenzymes; Molecular Structure; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Quantitative Structure-Activity Relationship | 2008 |
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
QSPR modeling of octanol/water partition coefficient of antineoplastic agents by balance of correlations.
Topics: Antineoplastic Agents; Models, Chemical; Octanols; Quantitative Structure-Activity Relationship; Water | 2010 |
Multi-target spectral moment QSAR versus ANN for antiparasitic drugs against different parasite species.
Topics: Antiparasitic Agents; Molecular Structure; Neural Networks, Computer; Parasitic Diseases; Quantitative Structure-Activity Relationship; Species Specificity; Thermodynamics | 2010 |
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests | 2013 |
The sensitivity to cytotoxic agents of the EMT6 tumor in vivo. Comparative response of lung nodules in rapid expotential growth and of the solid flank tumour.
Topics: Animals; Antineoplastic Agents; Bleomycin; Carmustine; Cell Line; Cell Survival; Cyclophosphamide; Dose-Response Relationship, Drug; Doxorubicin; Lomustine; Lung Neoplasms; Male; Mice; Mice, Inbred BALB C; Neoplasms, Experimental; Time Factors | 1976 |
[Chemotherapy in bronchogenic carcinoma (author's transl)].
Topics: Antineoplastic Agents; Bleomycin; Carcinoma, Bronchogenic; Carmustine; Cyclophosphamide; Doxorubicin; Drug Therapy, Combination; Humans; Lomustine; Lung Neoplasms; Mechlorethamine; Methotrexate; Procarbazine; Vinblastine | 1977 |
Comparative chemosensitivity of exponential- versus plateau-phase cells in both in vitro model systems.
Topics: Animals; Antineoplastic Agents; Bleomycin; Carmustine; Cell Division; Cell Survival; Cells, Cultured; Doxorubicin; Kinetics; Lomustine; Lung Neoplasms; Mice; Mice, Inbred BALB C; Neoplasms, Experimental; Time Factors | 1976 |
Pharmacokinetic studies of a transplantable murine renal adenocarcinoma.
Topics: Adenocarcinoma; Animals; Bleomycin; Carmustine; Cyclophosphamide; Cytarabine; Doxorubicin; Drug Evaluation, Preclinical; Kidney Neoplasms; Lomustine; Mice; Mice, Inbred BALB C; Neoplasm Transplantation; Neoplasms, Experimental | 1977 |
The cause of G2-arrest in Chinese hamster ovary cells treated with anticancer drugs.
Topics: Animals; Antineoplastic Agents; Carmustine; Cell Division; Cell Fusion; Cells, Cultured; Chromosomes; Cricetinae; Cyclohexanecarboxylic Acids; DNA; Lomustine; Mitosis; Nitrogen Mustard Compounds; Teniposide; Zinostatin | 1976 |
Cell proliferation kinetics and drug sensitivity of exponential and stationary populations of cultured L1210 cells.
Topics: Amino Acids; Animals; Antineoplastic Agents; Carmustine; Cell Division; Cell Survival; Cells, Cultured; Culture Media; Cytarabine; Dactinomycin; Daunorubicin; DNA, Neoplasm; Doxorubicin; Glucose; Hydroxyurea; Kinetics; Leukemia L1210; Lomustine; Streptozocin; Thymidine; Vincristine | 1977 |
A structure-activity analysis of chemical and biological parameters of chloroethylnitrosoureas in mice.
Topics: Alkylation; Animals; Bone Marrow; Carmustine; Ethyl Chloride; Ethylnitrosourea; Half-Life; Leukemia L1210; Leukocyte Count; Lomustine; Male; Mice; Mice, Inbred BALB C; Mice, Inbred DBA; Neutrophils; Nitrosourea Compounds; Statistics as Topic; Streptozocin; Structure-Activity Relationship | 1977 |
Comparison of biochemical and biological effects of four nitrosoureas with differing carbamoylating activities.
Topics: Animals; Carmustine; Cell Survival; Cells, Cultured; Chemical Phenomena; Chemistry; DNA, Neoplasm; Ethylnitrosourea; Leukemia L1210; Lomustine; Neoplasm Proteins; Nitrosourea Compounds; RNA, Neoplasm; Streptozocin; Time Factors | 1978 |
DNA-protein cross-linking and DNA interstrand cross-linking by haloethylnitrosoureas in L1210 cells.
Topics: Animals; Carmustine; Cells, Cultured; Chemical Phenomena; Chemistry; DNA, Neoplasm; Endopeptidases; Leukemia L1210; Lomustine; Mechlorethamine; Neoplasm Proteins; Nitrosourea Compounds; Streptozocin | 1978 |
Measurements of DNA damage in Chinese hamster cells treated with equitoxic and equimutagenic doses of nitrosoureas.
Topics: Carmustine; Cell Line; Cell Survival; Cyanates; DNA; Dose-Response Relationship, Drug; Ethyl Chloride; Lomustine; Methylnitrosourea; Mutation; Nitrosourea Compounds; Streptozocin; Time Factors | 1978 |
Examination of four newly synthesized 2-chloroethylnitrosoureas in comparison with BCNU, CCNU, MeCCNU, chlorozotocin and hydroxyethyl-CNU in preterminal rat leukemia L 5222.
Topics: Animals; Carmustine; Drug Evaluation, Preclinical; Female; Leukemia, Experimental; Lomustine; Male; Nitrosourea Compounds; Rats; Semustine; Streptozocin | 1979 |
Clinical management of advanced gastrointestinal cancer.
Topics: Adenoma, Islet Cell; Carcinoma, Hepatocellular; Carmustine; Colonic Neoplasms; Cytarabine; Drug Therapy, Combination; Floxuridine; Fluorouracil; Gastrointestinal Neoplasms; Humans; Liver Neoplasms; Lomustine; Malignant Carcinoid Syndrome; Mitomycins; Pancreatic Neoplasms; Rectal Neoplasms; Stomach Neoplasms; Streptozocin | 1975 |
Walter Hubert lecture Chemotherapy of upper gastrointestinal carcinoma.
Topics: Adenoma, Islet Cell; Antineoplastic Agents; Carcinoid Tumor; Carcinoma, Hepatocellular; Carcinoma, Squamous Cell; Carmustine; Colonic Neoplasms; Drug Therapy, Combination; Esophageal Neoplasms; Fluorouracil; Gastrointestinal Neoplasms; Humans; Liver Neoplasms; Lomustine; Malignant Carcinoid Syndrome; Nitrosourea Compounds; Pancreatic Neoplasms; Pyrimidines; Rectal Neoplasms; Stomach Neoplasms; Streptozocin | 1976 |
Single-agent chemotherapy of brain tumors. A five-year review.
Topics: Astrocytoma; Bone Marrow Diseases; Brain Neoplasms; Carmustine; Glioma; Humans; Imidazoles; Lomustine; Medulloblastoma; Melanoma; Nitrosourea Compounds; Peripheral Nervous System Diseases; Procarbazine; Time Factors; Vincristine | 1976 |
Chemotherapeutic trials on human malignant astrocytomas in organ culture.
Topics: Antineoplastic Agents; Astrocytoma; Carmustine; Cell Survival; Cyanides; Drug Evaluation, Preclinical; Etoposide; Humans; Lomustine; Luciferases; Methylprednisolone; NAD; Organ Culture Techniques | 1977 |
[Polychemotherapy of glioblastoma multiforme].
Topics: Adult; Brain Neoplasms; Carmustine; Glioblastoma; Humans; Lomustine; Male | 1977 |
Adjuvant chemotherapy with nitrosourea compounds following surgery plus radiotherapy in glioblastoma multiforme.
Topics: Brain Neoplasms; Carmustine; Glioblastoma; Humans; Lomustine; Nitrosourea Compounds; Semustine | 1978 |
[Value of chemotherapy associated with conventional treatment of malignant gliomas of the brain. Study of 95 cases with histological verification and follow-up of 1 to 6 years 9 months].
Topics: Administration, Oral; Adult; Brain Neoplasms; Carmustine; Drug Evaluation; Drug Therapy, Combination; Female; Follow-Up Studies; Glioblastoma; Glioma; Humans; Injections, Intravenous; Lomustine; Male; Middle Aged; Nitrosourea Compounds; Podophyllotoxin; Retrospective Studies; Teniposide | 1979 |
Mutagenicity of nitrosourea compounds for Salmonella typhimurium.
Topics: Carmustine; Lomustine; Methods; Methylnitrosourea; Mutagens; Nitrosourea Compounds; Salmonella typhimurium; Semustine | 1978 |
Clinical bone marrow transplantation (BMT) in children with acute lymphoblastic leukemia (ALL). Presentation of cases (Munchen group) [proceedings].
Topics: Bone Marrow Transplantation; Carmustine; Child; Cyclophosphamide; Cytarabine; Female; Graft Survival; Humans; Leukemia, Lymphoid; Lomustine; Male; Transplantation, Homologous | 1978 |
Combined effects of BCG or Candida albicans (CA) with antitumor agents against a virus-induced lymphoma in mice.
Topics: Adjuvants, Immunologic; Animals; Antineoplastic Agents; BCG Vaccine; Candida albicans; Carmustine; Drug Synergism; Drug Therapy, Combination; Female; Leukemia, Experimental; Lomustine; Lymphoma; Male; Mice; Mice, Inbred BALB C; Moloney murine leukemia virus; Nitrosourea Compounds | 1979 |
Treatment of primitive malignant tumors of the central nervous system. Clinical evaluation of 91 cases.
Topics: Astrocytoma; Brain Neoplasms; Carmustine; Ependymoma; Glioma; Humans; Lomustine; Oligodendroglioma | 1979 |
Response of exponentially growing, stationary-phase, and synchronized cultured human colon carcinoma cells to treatment with nitrosourea derivatives.
Topics: Carmustine; Cell Cycle; Cell Division; Cell Survival; Cells, Cultured; Colonic Neoplasms; Dose-Response Relationship, Drug; Humans; Interphase; Lomustine; Nitrosourea Compounds | 1979 |
Design and evaluation of combination chemotherapy trials in experimental animal tumor systems.
Topics: Animals; Antineoplastic Agents; Carmustine; Cisplatin; Colonic Neoplasms; Drug Evaluation, Preclinical; Drug Therapy, Combination; Evaluation Studies as Topic; Fluorouracil; Lomustine; Mice; Mice, Inbred BALB C; Mice, Inbred DBA; Neoplasms, Experimental; Research Design; Semustine | 1979 |
Reactions of 1,3-bis(2-chloroethyl)-1-nitrosourea and 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea in aqueous solution.
Topics: Carmustine; Chemical Phenomena; Chemistry; Lomustine; Nitrosourea Compounds; Solutions; Water | 1979 |
Comparison of the CCNU and BCNU modification of the in vitro radiation response in 9L brain tumor cells of rats.
Topics: Animals; Brain Neoplasms; Carmustine; Cell Survival; Cells, Cultured; Dose-Response Relationship, Drug; Lomustine; Neoplasms, Experimental; Nitrosourea Compounds; Rats; Time Factors | 1979 |
Mechanism of uptake of nitrosoureas by L5178Y lymphoblasts in vitro.
Topics: Animals; Biological Transport; Carmustine; Cell Membrane; Cells, Cultured; Cyanates; Cytosol; Kinetics; Leukemia, Experimental; Lomustine; Nitrosourea Compounds; Sodium | 1977 |
DNA damage and repair in mouse leukemia L1210 cells treated with nitrogen mustard, 1,3-bis(2-chloroethyl)-1-nitrosourea, and other nitrosoureas.
Topics: Animals; Carmustine; Cell Survival; Cells, Cultured; Chemical Phenomena; Chemistry; DNA Repair; DNA, Neoplasm; DNA, Single-Stranded; Leukemia L1210; Lomustine; Mechlorethamine; Methylnitrosourea; Neoplasm Proteins; Nitrosourea Compounds | 1977 |
Desmosterol: a biochemical marker of glioma growth.
Topics: Astrocytoma; Brain Neoplasms; Carmustine; Cholesterol; Chromatography, Gas; Desmosterol; Diagnosis, Differential; Ependymoma; Glioma; Humans; Lomustine; Medulloblastoma; Oligodendroglioma; Triparanol | 1977 |
Paraneoplastic syndrome in childhood.
Topics: Brain Diseases; Carmustine; Child, Preschool; Humans; Lomustine; Male; Mediastinal Neoplasms; Methotrexate; Neuroblastoma; Syndrome | 1977 |
Chemotherapy of human nervous system tumors: influence on cerebrospinal fluid sterols.
Topics: Adult; Antineoplastic Agents; Brain Neoplasms; Carmustine; Cholesterol; Desmosterol; Female; Humans; Lomustine; Male; Middle Aged | 1977 |
The contemporary role of chemotherapy in the treatment of malignant brain tumor.
Topics: Adrenal Cortex Hormones; Animals; Brain Neoplasms; Carmustine; Dose-Response Relationship, Drug; Drug Evaluation; Glioma; Humans; Inactivation, Metabolic; Lomustine; Neoplasms, Experimental; Prognosis; Radiotherapy Dosage; Semustine | 1978 |
Rationale of chemotherapeutic adjuvant treatment.
Topics: Animals; Antibiotics, Antineoplastic; Antineoplastic Agents; Carmustine; Cyclophosphamide; Drug Administration Schedule; Fluorouracil; Humans; Leukemia L1210; Lomustine; Mercaptopurine; Methotrexate; Mice; Neoplasms | 1978 |
Visual abnormalities following nitrosourea treatment.
Topics: Carmustine; Humans; Lomustine; Nitrosourea Compounds; Retina; Semustine; Vision Disorders; Visual Acuity | 1978 |
Correlations between experimental chemotherapy in the murine glioma and effectiveness of clinical therapy regimens.
Topics: Animals; Carmustine; Dianhydrogalactitol; Drug Therapy, Combination; Ellipticines; Glioma; Lomustine; Male; Mice; Mice, Inbred C57BL; Neoplasm Transplantation; Neoplasms, Experimental; Procarbazine; Time Factors; Transplantation, Homologous | 1978 |
Relationship of 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU) and 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea (CCNU) pharmacokinetics of uptake, distribution, and tissue/plasma partitioning in rat organs and intracerebral tumors.
Topics: Animals; Brain Neoplasms; Carmustine; DNA; Kinetics; Lomustine; Male; Neoplasm Proteins; Nitrosourea Compounds; Protein Binding; Rats; Rats, Inbred F344; RNA; Tissue Distribution | 1978 |
The effect of phenobarbital pretreatment on the antitumor activity of 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU), 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea (CCNU) and 1-(2-chloroethyl)-3-(2,6-dioxo-3-piperidyl-1-nitrosourea (PCNU), and on the plasma p
Topics: Alkylating Agents; Animals; Biotransformation; Brain Neoplasms; Carmustine; Dexamethasone; Drug Interactions; In Vitro Techniques; Kinetics; Liver; Lomustine; Male; Methylprednisolone; Neoplasms, Experimental; Nitrosourea Compounds; Phenobarbital; Phenytoin; Rats; Rats, Inbred F344 | 1979 |
Multimodal surgical adjuvant therapy for a broad spectrum of tumors in humans.?
Topics: Adult; Altretamine; Antineoplastic Agents; Bone Neoplasms; Breast Neoplasms; Carmustine; Colonic Neoplasms; Cyclophosphamide; Dacarbazine; Doxorubicin; Drug Evaluation; Female; Fluorouracil; Head and Neck Neoplasms; Humans; Lomustine; Lung Neoplasms; Male; Melanoma; Mitolactol; Neoplasms; Osteosarcoma; Pancreatic Neoplasms; Rectal Neoplasms; Vincristine | 1976 |
Pharmacology of the nitrosoureas: an overview.
Topics: Animals; Carmustine; Dogs; Half-Life; Haplorhini; Humans; Lomustine; Mice; Microsomes, Liver; Nitrosourea Compounds; Semustine | 1976 |
Interstrand cross-linking of DNA by 1,3-bis(2-chloroethyl)-1-nitrosourea and other 1-(2-haloethyl)-1-nitrosoureas.
Topics: Carmustine; Chemical Phenomena; Chemistry; DNA; Kinetics; Lomustine; Methylnitrosourea; Nitrosourea Compounds | 1977 |
Single drug and combination chemotherapy in the treatment. Disseminated malignant melanoma.
Topics: Antineoplastic Agents; Carmustine; Dacarbazine; Drug Therapy, Combination; Humans; Hydroxyurea; Lomustine; Melanoma; Neoplasm Metastasis; Skin Neoplasms; Vincristine | 1977 |
Chemotherapy of brain tumors.
Topics: Brain Neoplasms; Carmustine; Drug Combinations; Glioma; Humans; Lomustine; Methotrexate; Podophyllotoxin; Vincristine | 1976 |
A chemical basis for the antitumor activity of chloroethylnitrosoureas.
Topics: Animals; Antineoplastic Agents; Buffers; Carmustine; Chemical Phenomena; Chemistry; Ethylnitrosourea; Ions; Leukemia L1210; Lomustine; Nitrosourea Compounds; Solutions; Time Factors | 1976 |
Gastrointestinal cancer. Treatment with fluorouracil-nitrosourea combinations.
Topics: Carmustine; Colonic Neoplasms; Drug Therapy, Combination; Female; Fluorouracil; Gastrointestinal Neoplasms; Humans; Liver Neoplasms; Lomustine; Male; Methods; Nitrosourea Compounds; Pancreatic Neoplasms; Rectal Neoplasms; Remission, Spontaneous; Semustine; Stomach Neoplasms | 1976 |
The nitrosoureas: an outline of clinical schedules and toxic effects.
Topics: Administration, Oral; Bone Marrow; Capsules; Carmustine; Humans; Injections, Intravenous; Lomustine; Nausea; Nitrosourea Compounds; Semustine | 1976 |
Nitrosourea chemotherapy for primary malignant gliomas.
Topics: Brain Neoplasms; Carmustine; Drug Therapy, Combination; Fluorouracil; Glioma; Humans; Lomustine; Neoplasm Recurrence, Local; Nitrosourea Compounds; Procarbazine; Semustine; Vincristine | 1976 |
Nitrosourea pharmacodynamics in relation to the central nervous system.
Topics: Animals; Blood-Brain Barrier; Brain Neoplasms; Carmustine; Glioma; Humans; Lomustine; Mice; Molecular Weight; Neoplasms, Experimental; Nitrosourea Compounds; Semustine; Solubility | 1976 |
Clinical studies with nitrosoureas in various solid tumors.
Topics: Adenocarcinoma; Breast Neoplasms; Carcinoma, Squamous Cell; Carmustine; Female; Genital Neoplasms, Female; Head and Neck Neoplasms; Humans; Kidney Neoplasms; Lomustine; Male; Neoplasms; Nitrosourea Compounds; Sarcoma; Semustine; Testicular Neoplasms | 1976 |
Sterols in cerebrospinal fluid during nitrosourea chemotherapy of human brain tumors.
Topics: Adult; Astrocytoma; Brain Neoplasms; Carmustine; Cholesterol; Desmosterol; Female; Glioma; Humans; Infant; Lomustine; Male; Middle Aged; Nitrosourea Compounds; Oligodendroglioma | 1976 |
Effects of nitrosoureas on human DNA polymerase activities from acute and chronic granulocytic leukemia cells.
Topics: Acute Disease; Carmustine; Chronic Disease; DNA Nucleotidyltransferases; Granulocytes; Humans; Kinetics; Leukemia, Myeloid; Leukocytes; Lomustine; Nitrosourea Compounds; Templates, Genetic | 1976 |
Decomposition of N-(2-chloroethyl)-N-nitrosoureas in aqueous media.
Topics: Carmustine; Chemical Phenomena; Chemistry; Chromatography, Gas; Lomustine; Mass Spectrometry; Nitrogen Mustard Compounds; Nitrosourea Compounds; Water | 1975 |
Changes in sensitivity to cytotoxic agents occurring during the life history of monolayer cultures of a mouse tumour cell line.
Topics: Alkylating Agents; Animals; Antibiotics, Antineoplastic; Carmustine; Cell Division; Cell Line; Cell Survival; Dactinomycin; Dose-Response Relationship, Drug; Doxorubicin; Lomustine; Mechlorethamine; Mice; Neoplasms, Experimental | 1975 |
Treatment of mycosis fungoides with topical nitrosourea compounds: Further studies.
Topics: Administration, Topical; Adult; Aged; Bone Marrow; Carmustine; Cross Reactions; Drug Hypersensitivity; Female; Humans; Lomustine; Male; Mechlorethamine; Methylnitrosourea; Middle Aged; Mycosis Fungoides; Nitrosourea Compounds; Skin Neoplasms | 1975 |
Editorial: Large-bowel cancer-The current status of treatment.
Topics: Adjuvants, Immunologic; BCG Vaccine; Carmustine; Colonic Neoplasms; Doxorubicin; Drug Therapy, Combination; Fluorouracil; Immunotherapy; Lomustine; Mitomycins; Neoplasm Metastasis; Neoplasm Recurrence, Local; Rectal Neoplasms; Semustine; United States | 1976 |
A comparison of the lethal effects of three nitrosourea derivatives on cultured human lymphoma cells.
Topics: Amphotericin B; Carmustine; Cell Line; Cell Survival; Cells, Cultured; Dose-Response Relationship, Drug; Lomustine; Lymphoma; Neoplasms, Experimental; Nitrosourea Compounds; Semustine; Time Factors; Vitamin A | 1976 |
Nitrosoureas: important new drugs for the treatment of cancer.
Topics: Carmustine; Humans; Lomustine; Neoplasms; Nitrosourea Compounds | 1976 |
Chemotherapy for colorectal carcinoma.
Topics: Antineoplastic Combined Chemotherapy Protocols; Carmustine; Chemotherapy, Adjuvant; Colorectal Neoplasms; Drug Administration Schedule; Fluorouracil; Humans; Lomustine; Mitomycin; Tegafur | 1992 |
Effect of O6-benzylguanine analogues on sensitivity of human tumor cells to the cytotoxic effects of alkylating agents.
Topics: Alkylating Agents; Antineoplastic Agents; Carmustine; Cell Survival; Cisplatin; Cyclophosphamide; DNA; DNA Damage; Drug Synergism; Guanine; Humans; In Vitro Techniques; Lomustine; Mesylates; Methyltransferases; O(6)-Methylguanine-DNA Methyltransferase; Streptozocin; Tumor Cells, Cultured | 1991 |
New approaches to the chemotherapy of melanoma.
Topics: Alkaloids; Amifostine; Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Bone Marrow Transplantation; Carmustine; Cisplatin; Cyclophosphamide; Dacarbazine; Daunorubicin; Humans; Lomustine; Melanoma; Nitrosourea Compounds; Paclitaxel; Procarbazine; Tamoxifen; Taurine; Thiotepa; Vincristine; Vindesine | 1991 |
Effect of O6-benzylguanine on the sensitivity of human tumor xenografts to 1,3-bis(2-chloroethyl)-1-nitrosourea and on DNA interstrand cross-link formation.
Topics: Animals; Carmustine; Colonic Neoplasms; DNA; DNA, Neoplasm; DNA, Single-Stranded; Drug Resistance; Drug Screening Assays, Antitumor; Drug Synergism; Female; Guanine; Humans; Lomustine; Mice; Mice, Nude; Transplantation, Heterologous; Tumor Cells, Cultured | 1992 |
Nitrosoureas lomustine, carmustine and fotemustine induced hepatotoxic perturbations in rats: biochemical, morphological and flow cytometry studies.
Topics: Alkaline Phosphatase; Animals; Bilirubin; Carmustine; Cell Cycle; DNA; Dose-Response Relationship, Drug; Flow Cytometry; Liver; Lomustine; Nitrosourea Compounds; Organophosphorus Compounds; Rats; Transaminases | 1991 |
2-Nitroimidazole potentiation of nitrosourea induced cytotoxicity in subcutaneous implants of rat 9L brain tumor cells.
Topics: Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Carmustine; Cell Line; Cell Survival; Drug Synergism; Etanidazole; Lomustine; Male; Misonidazole; Nitroimidazoles; Rats; Rats, Inbred F344; Streptozocin; Tumor Stem Cell Assay | 1991 |
Thyroid function after treatment of brain tumors in children.
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Astrocytoma; Brain Neoplasms; Carmustine; Child; Child, Preschool; Cohort Studies; Combined Modality Therapy; Cranial Irradiation; Female; Glioma; Humans; Infant; Life Tables; Lomustine; Male; Procarbazine; Radiotherapy Dosage; Regression Analysis; Spinal Cord; Thyroid Diseases; Thyroid Gland; Thyrotropin; Thyroxine; Vincristine | 1991 |
Chemosensitization of the nitrosoureas by 2-nitroimidazoles in the subcutaneous 9L tumor model: pharmacokinetic and structure-activity considerations.
Topics: Animals; Carmustine; Drug Synergism; Etanidazole; Lomustine; Male; Misonidazole; Neoplasm Transplantation; Neoplasms, Experimental; Nitroimidazoles; Nitrosourea Compounds; Rats; Rats, Inbred F344; Structure-Activity Relationship | 1990 |
Cisplatin and CCNU synergism in spheroid cell subpopulations.
Topics: Animals; Carmustine; Cell Hypoxia; Cell Line; Cell Survival; Cisplatin; Cricetinae; Dose-Response Relationship, Drug; Drug Synergism; Lomustine | 1990 |
The VM model of glioma: preparation of multicellular tumour spheroids (MTS) and their response to chemotherapy.
Topics: Animals; Carmustine; Cell Division; Disease Models, Animal; Drug Screening Assays, Antitumor; Glioma; Lomustine; Mice; Procarbazine; Tumor Cells, Cultured; Vincristine | 1990 |
The chemotherapeutic response of a murine (VM) model of human glioma.
Topics: Animals; Astrocytoma; Brain Neoplasms; Carmustine; Disease Models, Animal; Lomustine; Mice; Mice, Inbred Strains; Procarbazine; Skin Neoplasms; Vincristine | 1990 |
In vitro chemosensitivity testing of Fotemustine (S 10036), a new antitumor nitrosourea.
Topics: Antineoplastic Agents; Carmustine; Cell Division; Cisplatin; Dacarbazine; Drug Screening Assays, Antitumor; Drug Synergism; Humans; Lomustine; Melanoma; Nitrosourea Compounds; Organophosphorus Compounds; Thymidine; Tumor Cells, Cultured | 1990 |
Lysis of human promyelocytic HL-60 cells by amphotericin B in combination with 2-chloroethyl-1-nitrosoureas: role of the carbamoylating activity of nitrosoureas.
Topics: Amphotericin B; Carmustine; Cell Line; Drug Therapy, Combination; Glutathione; Humans; L-Lactate Dehydrogenase; Leukemia, Promyelocytic, Acute; Lomustine; Nitrosourea Compounds | 1990 |
Chemotherapy for malignant gliomas of the brain: a review of ten-years experience.
Topics: Antineoplastic Agents; Aziridines; Benzoquinones; Brain Neoplasms; Carmustine; Cyclohexenes; Glioma; Humans; Lomustine | 1990 |
Base sequence specificity of three 2-chloroethylnitrosoureas.
Topics: Alkylation; Base Sequence; Carmustine; Chemical Phenomena; Chemistry; Chromatography, High Pressure Liquid; DNA; Guanine; Lomustine; Nitrosourea Compounds; Semustine; Structure-Activity Relationship | 1990 |
Response of cultured human cell lines from rhabdomyosarcoma xenografts to treatment with chloroethylnitrosoureas.
Topics: Animals; Antineoplastic Agents; Carmustine; Cell Division; Cell Survival; Drug Screening Assays, Antitumor; Humans; Kinetics; Lomustine; Methyltransferases; O(6)-Methylguanine-DNA Methyltransferase; Rhabdomyosarcoma; Streptozocin; Transplantation, Heterologous; Tumor Cells, Cultured | 1989 |
Modulation of human lymphocyte O6-alkylguanine-DNA alkyltransferase by streptozotocin in vivo.
Topics: Carmustine; Cisplatin; DNA Repair; DNA, Neoplasm; Drug Resistance; Humans; Lomustine; Lymphocytes; Methyltransferases; Neoplasms; O(6)-Methylguanine-DNA Methyltransferase; Streptozocin | 1989 |
Ovarian function following chemotherapy for childhood brain tumours.
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Carmustine; Child; Child, Preschool; Female; Humans; Lomustine; Menarche; Ovary; Procarbazine; Puberty | 1989 |
Expression of mammalian O6-alkylguanine-DNA alkyltransferase in a cell line sensitive to alkylating agents.
Topics: Alkylating Agents; Animals; Carmustine; Cell Division; Cell Line; Cricetinae; Cricetulus; Female; Guanine; Kinetics; Lomustine; Methylnitronitrosoguanidine; Methylnitrosourea; Methyltransferases; Mitoguazone; O(6)-Methylguanine-DNA Methyltransferase; Ovary; Transfection | 1989 |
Glutathione and related enzymes in rat brain tumor cell resistance to 1,3-bis(2-chloroethyl)-1-nitrosourea and nitrogen mustard.
Topics: Animals; Brain Neoplasms; Buthionine Sulfoximine; Carmustine; Cell Line; Cell Survival; Chromatography, High Pressure Liquid; Clone Cells; Dinitrochlorobenzene; Drug Resistance; gamma-Glutamyltransferase; Glioma; Glutathione; Glutathione Transferase; Lomustine; Mechlorethamine; Methionine Sulfoximine; Rats; Semustine | 1987 |
Inhibition of intracellular esterases by antitumour chloroethylnitrosoureas. Measurement by flow cytometry and correlation with molecular carbamoylation activity.
Topics: Animals; Antineoplastic Agents; Carmustine; Esterases; Ethylnitrosourea; Flow Cytometry; Lomustine; Mice; Proteins; Spectrometry, Fluorescence; Streptozocin; Structure-Activity Relationship | 1988 |
Effect of nitrosoureas on calmodulin activity in vitro and in mouse intestine in vivo.
Topics: Animals; Calcium; Calmodulin; Carmustine; Cattle; Cyanates; Cyclic AMP; Intestinal Mucosa; Intestines; Lomustine; Male; Mice; Nitrosourea Compounds; Phosphoric Diester Hydrolases; Semustine; Streptozocin | 1985 |
Supraophthalmic carotid infusion for recurrent glioma: rationale, technique, and preliminary results for cisplatin and BCNU.
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Astrocytoma; Brain Neoplasms; Carmustine; Carotid Artery, Internal; Cisplatin; Glioblastoma; Glioma; Humans; Infusions, Intra-Arterial; Lomustine; Middle Aged; Prognosis; Tomography, X-Ray Computed | 1985 |
In vitro analysis of BCNU-sensitivity in human malignant gliomas. II. Cross-resistance studies with cisplatinum and nitrosoureas.
Topics: Brain Neoplasms; Carmustine; Cells, Cultured; Cisplatin; Drug Resistance; Glioblastoma; Humans; Lomustine; Tumor Stem Cell Assay | 1986 |
Effect of Fluosol-DA/O2 on tumor-cell and bone-marrow cytotoxicity of nitrosoureas in mice bearing FSA-II fibrosarcoma.
Topics: Animals; Bone Marrow; Carbon Dioxide; Carmustine; Cell Survival; Drug Combinations; Fibrosarcoma; Fluorocarbons; Hydroxyethyl Starch Derivatives; Lomustine; Male; Mice; Mice, Inbred C3H; Nitrosourea Compounds; Oxygen; Semustine | 1986 |
Medulloblastoma at the joint center for radiation therapy between 1968 and 1984. The influence of radiation dose on the patterns of failure and survival.
Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Carmustine; Cerebellar Neoplasms; Child; Child, Preschool; Cisplatin; Combined Modality Therapy; Cyclophosphamide; Evaluation Studies as Topic; Female; Humans; Infant; Lomustine; Male; Medulloblastoma; Neoplasm Recurrence, Local; Particle Accelerators; Radiotherapy Dosage; Radiotherapy, High-Energy; Spinal Neoplasms; Vincristine | 1988 |
Testicular damage after chemotherapy for childhood brain tumors.
Topics: Adolescent; Adult; Brain Neoplasms; Carmustine; Child; Follicle Stimulating Hormone; Follow-Up Studies; Humans; Lomustine; Luteinizing Hormone; Male; Testis; Testosterone | 1988 |
Chemical specificity for induction of stress response genes by DNA-damaging drugs in human adenocarcinoma cells.
Topics: Adenocarcinoma; Antineoplastic Agents; Carmustine; Cell Line; Colonic Neoplasms; DNA Damage; Genes; Heat-Shock Proteins; Humans; Kinetics; Lomustine | 1988 |
Capillary gas chromatography and thermionic N-P-specific detection of 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU) or 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea (CCNU) in stability and pharmacokinetic studies.
Topics: Animals; Calibration; Carmustine; Chromatography, Gas; Drug Stability; Lomustine; Rabbits; Reproducibility of Results | 1988 |
Interference with effects of amphotericin B on Candida albicans cells by 2-chloroethyl-1-nitrosoureas.
Topics: Amphotericin B; Candida albicans; Carmustine; Catalase; Cyanates; Drug Interactions; Lomustine | 1988 |
Nitrosoureido nucleosides as potential inhibitors of nucleotide biosynthesis.
Topics: Animals; Carmustine; Cell Division; DNA Replication; Drug Stability; Indicators and Reagents; Leukemia L1210; Lomustine; Mice; Neoplasm Proteins; Nitrosourea Compounds; Nucleosides; Nucleotides; Structure-Activity Relationship; Transcription, Genetic | 1988 |
Successful chemotherapy for recurrent malignant oligodendroglioma.
Topics: Adult; Antineoplastic Agents; Aziridines; Benzoquinones; Brain Neoplasms; Carmustine; Female; Humans; Lomustine; Male; Middle Aged; Oligodendroglioma; Procarbazine; Vincristine | 1988 |
[Synthesis of antitumor nitrosourea derivatives and chemical studies of their mechanism of action].
Topics: Antineoplastic Agents; Bone Marrow; Carmustine; Humans; Lomustine; Nimustine; Nitroso Compounds; Nitrosourea Compounds | 1986 |
Nature and biological significance of DNA modification by the haloethylnitrosoureas.
Topics: Antineoplastic Agents; Carmustine; Chromatography, High Pressure Liquid; Cross-Linking Reagents; DNA; DNA Damage; DNA Repair; Ethylnitrosourea; Lomustine; Nitrosourea Compounds; Spectrophotometry, Ultraviolet; Structure-Activity Relationship | 1986 |
Appraisal of blood vessels in the rat brain following administration of nitrosourea derivatives.
Topics: Animals; Brain; Capillary Permeability; Carmustine; Female; Lomustine; Male; Rats; Rats, Inbred Strains | 1986 |
Effect of cell cycle position on the survival of 9L cells treated with nitrosoureas that alkylate, cross-link, and carbamoylate.
Topics: Alkylating Agents; Animals; Brain Neoplasms; Carbamates; Carmustine; Cell Cycle; Cell Line; Cell Survival; Cross-Linking Reagents; Ethylnitrosourea; Lomustine; Nitroso Compounds; Nitrosourea Compounds; Rats; Structure-Activity Relationship | 1986 |
Effects of sodium cyanate in mice bearing B16 melanoma.
Topics: Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Body Weight; Carmustine; Cyanates; Eating; Female; Lomustine; Melanoma; Mice; Mice, Inbred C57BL; Thymidine | 1986 |
Carcinogenesis in F-344 rats induced by nitrosohydroxyalkyl-chloroethylureas.
Topics: Animals; Carmustine; Ethylnitrosourea; Female; Lomustine; Magnetic Resonance Spectroscopy; Male; Neoplasms, Experimental; Nitrosourea Compounds; Rats; Rats, Inbred F344; Rats, Inbred Strains | 1986 |
Effect of inhibition of glutathione reductase by carmustine on central nervous system oxygen toxicity.
Topics: Animals; Carmustine; Glucosephosphate Dehydrogenase; Glutathione Reductase; Lomustine; Male; Nitrosourea Compounds; Oxygen; Rats; Rats, Inbred Strains; Seizures; Superoxide Dismutase; Time Factors | 1987 |
Sequential treatment with interferon and chemotherapy of metastatic malignant melanoma. Total remission of cutaneous and visceral metastasis, but not of cerebral metastasis.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Brain Neoplasms; Carmustine; Combined Modality Therapy; Dacarbazine; Drug Evaluation; Female; Humans; Interferon Type I; Lomustine; Lymphatic Metastasis; Male; Melanoma; Middle Aged; Recombinant Proteins; Skin Neoplasms; Vincristine | 1987 |
Sensitization of cancer chemotherapeutic agents by nitroheterocyclics.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Carmustine; Cell Survival; Drug Synergism; Heterocyclic Compounds; Hydroxamic Acids; Hypoxia; Lomustine; Misonidazole; Neoplasms, Experimental; Nitroimidazoles; Radiation-Sensitizing Agents | 1986 |
Emergence of nitrosourea resistant sublines of Lewis lung tumour following MeCCNU treatment in vivo.
Topics: Animals; Carmustine; Cell Line; Cell Survival; Cisplatin; Cyclophosphamide; Dose-Response Relationship, Drug; Drug Resistance; Lomustine; Lung Neoplasms; Melphalan; Mice; Mice, Inbred C57BL; Neoplasm Transplantation; Nitrosourea Compounds; Semustine; Time Factors | 1986 |
Thermochemotherapy with cis-platinum, CCNU, BCNU, chlorambucil and melphalan on murine marrow and two tumours: therapeutic gain for melphalan only.
Topics: Animals; Antineoplastic Agents; Bone Marrow; Carmustine; Chlorambucil; Cisplatin; Combined Modality Therapy; Dose-Response Relationship, Drug; Female; Hyperthermia, Induced; Lomustine; Melphalan; Mice; Mice, Inbred C3H; Neoplasms, Experimental | 1985 |
DNA polymerases in normal and regenerating rat liver and hepatomas: targets for chemotherapy.
Topics: Animals; Antineoplastic Agents; Carcinoma, Hepatocellular; Carmustine; Cell Fractionation; Cyanates; DNA; DNA Nucleotidyltransferases; DNA, Neoplasm; Enzyme Activation; Liver; Liver Neoplasms; Liver Regeneration; Lomustine; Male; Membranes; Nitrosourea Compounds; Rats; Ribonucleotide Reductases; Thymidine Kinase; Thymidylate Synthase | 1974 |
Sequential administration of two oncostatic drugs: study of modalities for pharmacodynamic potentiation.
Topics: Animals; Antineoplastic Agents; Carmustine; Cyclophosphamide; Cytarabine; Dactinomycin; Drug Synergism; Drug Therapy, Combination; Female; Fluorouracil; Kinetics; Leukemia L1210; Lomustine; Mathematics; Methotrexate; Mice; Mitomycins; Neoplasm Transplantation; Nitrosourea Compounds; Time Factors; Vincristine | 1974 |
DTIC, CCNU, bleomycin and vincristine (BOLD) in metastatic melanoma.
Topics: Antineoplastic Agents; Bleomycin; Carmustine; Drug Administration Schedule; Drug Evaluation; Drug Therapy, Combination; Humans; Lomustine; Melanoma; Thrombocytopenia; Vincristine; Vomiting | 1980 |
Increased mutagenicity of chloroethylnitrosoureas in the presence of a rat liver S9 microsome mixture.
Topics: Animals; Aroclors; Biotransformation; Carmustine; Chlorodiphenyl (54% Chlorine); Cyclophosphamide; Lomustine; Microsomes, Liver; Mutagenicity Tests; Mutagens; Mutation; Nitrosourea Compounds; Rats; Salmonella typhimurium; Streptozocin | 1983 |
Therapeutic evaluation of five nitrosoureas in a human melanoma xenograft system.
Topics: Animals; Bone Marrow; Brain Neoplasms; Carmustine; Dose-Response Relationship, Drug; Female; Humans; Lomustine; Male; Melanoma; Mice; Mice, Nude; Neoplasm Transplantation; Nitrosourea Compounds; Semustine; Streptozocin; Transplantation Immunology; Transplantation, Heterologous | 1983 |
Radiosensitizers: a conference preview.
Topics: Animals; Aziridines; Buthionine Sulfoximine; Carmustine; Combined Modality Therapy; Drug Synergism; Etanidazole; Humans; Ketones; Lomustine; Maleates; Methionine Sulfoximine; Mice; Misonidazole; Neoplasms; Nitroimidazoles; Radiation-Sensitizing Agents | 1984 |
Nitroimidazoles as modifiers of nitrosourea pharmacokinetics.
Topics: Animals; Antineoplastic Agents; Carmustine; Lomustine; Mice; Mice, Inbred C3H; Misonidazole; Nitroimidazoles; Nitrosourea Compounds; Radiation-Sensitizing Agents; Semustine; Streptozocin; Time Factors | 1984 |
Clinical toxicity of combined modality treatment with nitrosourea derivatives for central nervous system tumors.
Topics: Bone Marrow Diseases; Brain Neoplasms; Carmustine; Gastrointestinal Diseases; Glioblastoma; Glioma; Hematologic Diseases; Humans; Leukemia; Leukopenia; Lomustine; Meningeal Neoplasms; Nitrosourea Compounds; Sarcoma; Thrombocytopenia | 1982 |
Induction and repair of macromolecular damage by alkylating agents.
Topics: Animals; Carmustine; Cell Line; Cell Transformation, Neoplastic; Cell Transformation, Viral; Colony-Forming Units Assay; DNA Repair; DNA, Single-Stranded; Drug Resistance; Fibroblasts; Humans; Lomustine; Methylnitronitrosoguanidine; Methyltransferases; O(6)-Methylguanine-DNA Methyltransferase; Simian virus 40 | 1984 |
Massive BACT chemotherapy with autologous bone marrow transplantation in 17 cases of non-Hodgkin's malignant lymphoma with a very bad prognosis.
Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Bone Marrow Transplantation; Carmustine; Child; Child, Preschool; Combined Modality Therapy; Cyclophosphamide; Cytarabine; Female; Humans; Lomustine; Lymphoma; Male; Risk; Thioguanine; Whole-Body Irradiation | 1983 |
Megadose chemotherapy with bone marrow rescue.
Topics: Animals; Bone Marrow Transplantation; Brain Neoplasms; Carmustine; Combined Modality Therapy; Glioma; Humans; Lomustine; Melanoma; Neoplasms | 1984 |
Influence of polyamine depletion caused by alpha-difluoromethylornithine, an enzyme-activated irreversible inhibitor of ornithine decarboxylase, on alkylation- and carbamoylation-induced cytotoxicity in 9L rat brain tumor cells in vitro.
Topics: Animals; Antineoplastic Agents; Brain Neoplasms; Carboxy-Lyases; Carmustine; Cell Line; Cell Survival; Drug Synergism; Eflornithine; Ethylnitrosourea; Lomustine; Methylnitrosourea; Ornithine; Ornithine Decarboxylase Inhibitors; Polyamines; Rats | 1983 |
Effects of structure and chemical activity on the ability of nitrosoureas to inhibit DNA repair.
Topics: Animals; Carmustine; Cells, Cultured; DNA Repair; Leukemia L1210; Lomustine; Mice; Nitrosourea Compounds; Streptozocin; Structure-Activity Relationship | 1980 |
Preclinical and clinical studies on chlorozotocin, a new nitrosourea with decreased bone marrow toxicity.
Topics: Animals; Bone Marrow; Carmustine; Drug Evaluation; Drug Evaluation, Preclinical; Female; Humans; Leukemia L1210; Lomustine; Mice; Neoplasms; Streptozocin | 1980 |
[State of chemotherapy and adjuvant therapies in the treatment of stomach cancer].
Topics: Carmustine; Doxorubicin; Drug Therapy, Combination; Fluorouracil; Humans; Lomustine; Male; Middle Aged; Mitomycins; Stomach Neoplasms | 1984 |
Pharmacokinetics of nitrosoureas: comparison of 1,3-bis-(2-chloroethyl)-1-nitrosourea (BCNU) and 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea (CCNU) after oral and intravenous administration to rats.
Topics: Administration, Oral; Animals; Carmustine; Half-Life; Injections, Intravenous; Kinetics; Lomustine; Male; Rats; Rats, Inbred Strains | 1984 |
Pulmonary fibrosis subsequent to high doses of CCNU for chronic myeloid leukemia.
Topics: Adult; Carmustine; Female; Humans; Leukemia, Myeloid; Lomustine; Male; Nitrosourea Compounds; Pulmonary Fibrosis | 1983 |
Potentiation of cytotoxicity of anticancer agents by several different polyene antibiotics.
Topics: Animals; Anti-Bacterial Agents; Antineoplastic Agents; Carmustine; Cell Survival; Dose-Response Relationship, Drug; Doxorubicin; Drug Synergism; Lethal Dose 50; Leukemia, Experimental; Lomustine; Mice; Mice, Inbred AKR; Polyenes | 1984 |
[Antitumor activity of a new nitrosourea, MCNU, on a cellular morphological basis evaluated by a new in vitro antitumor sensitivity assay].
Topics: Animals; Antineoplastic Agents; Carmustine; Cell Survival; Dose-Response Relationship, Drug; Drug Resistance; Humans; In Vitro Techniques; Leukemia L1210; Lomustine; Nimustine; Nitrosourea Compounds; Semustine; Tumor Stem Cell Assay | 1984 |
The effects of BCNU (1,3-bis(2-chloroethyl)-1-nitrosourea) and CCNU (1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea) on glutathione reductase and other enzymes in mouse tissue.
Topics: Animals; Brain; Carmustine; Enzymes; Glutathione Reductase; Liver; Lomustine; Male; Mice; Myocardium; Time Factors | 1983 |
Effects of carbamoylation on cell survival and DNA repair in normal human embryo cells (IMR-90) treated with various 1-(2-chloroethyl)-1-nitrosoureas.
Topics: Carmustine; Cell Line; Cell Survival; DNA; DNA Repair; DNA Replication; Ethylnitrosourea; Female; Humans; Lomustine; Lung; Nitrosourea Compounds; Pregnancy; Structure-Activity Relationship | 1984 |
Hypoxic cells and in situ chemopotentiation of the nitrosoureas by misonidazole.
Topics: Animals; Brain Neoplasms; Carmustine; Cell Survival; Dose-Response Relationship, Drug; Drug Synergism; Lomustine; Misonidazole; Nitroimidazoles; Oxygen; Rats; Skin Neoplasms; Tumor Stem Cell Assay | 1984 |
Denitrosation of carcinostatic nitrosoureas by purified NADPH cytochrome P-450 reductase and rat liver microsomes to yield nitric oxide under anaerobic conditions.
Topics: Anaerobiosis; Animals; Biotransformation; Carmustine; Kinetics; Lomustine; Microsomes, Liver; NADP; NADPH-Ferrihemoprotein Reductase; Nitric Oxide; Nitrosourea Compounds; Oxidation-Reduction; Rats; Rats, Inbred Strains; Spectrophotometry | 1982 |
[Chemotherapy of stomach cancer].
Topics: Adenocarcinoma; Antineoplastic Agents; Carmustine; Cisplatin; Doxorubicin; Drug Administration Schedule; Drug Therapy, Combination; Fluorouracil; Gastrectomy; Humans; Lomustine; Mitomycin; Mitomycins; Neoplasm Recurrence, Local; Prognosis; Semustine; Stomach Neoplasms | 1982 |
In vivo chemosensitization by misonidazole in sensitive and resistant tumor lines.
Topics: Animals; Carmustine; Cell Line; Drug Resistance; Drug Synergism; Humans; Leukemia L1210; Lomustine; Mice; Mice, Inbred C3H; Misonidazole; Nitroimidazoles; Nitrosourea Compounds; Sarcoma, Experimental | 1983 |
Proper analysis of clinical trials for malignant glioma.
Topics: Carmustine; Glioma; Humans; Lomustine; Methods; Statistics as Topic | 1982 |
Quantitative dose-response relations for the cytotoxic activity of chloroethylnitrosoureas in cell culture.
Topics: Animals; Biotransformation; Brain Neoplasms; Carmustine; Cell Survival; Cells, Cultured; Dose-Response Relationship, Drug; Lomustine; Mustard Compounds; Neoplasms, Experimental; Nitrosourea Compounds; Rats; Semustine; Structure-Activity Relationship; Time Factors | 1982 |
Medulloblastoma in childhood. Multidisciplinary treatment.
Topics: Adolescent; Carmustine; Cerebellar Neoplasms; Cerebellum; Child; Child, Preschool; Female; Humans; Infant; Lomustine; Male; Medulloblastoma; Neoplasm Recurrence, Local; Prognosis | 1982 |
Modifications of DNA by different haloethylnitrosoureas.
Topics: Animals; Carmustine; Cattle; Chemical Phenomena; Chemistry; Chromatography, High Pressure Liquid; DNA; Ethylnitrosourea; Lomustine; Nitrosourea Compounds; Structure-Activity Relationship; Thymus Gland | 1982 |
The role of isocyanates in the toxicity of antitumour haloalkylnitrosoureas.
Topics: Animals; Antineoplastic Agents; Carmustine; Cyanates; Female; Leukemia L1210; Lomustine; Lymphoma; Mice; Mice, Inbred Strains; Neoplasms, Experimental; Nitrosourea Compounds | 1982 |
Mechanism of action of the nitrosoureas--IV. Reactions of bis-chloroethyl nitrosourea and chloroethyl cyclohexyl nitrosourea with deoxyribonucleic acid.
Topics: Animals; Carmustine; Cattle; Chemical Phenomena; Chemistry; DNA; Lomustine; Nitrosourea Compounds; Thymus Gland | 1980 |
Metabolism of 1,3-bis(2-chloroethyl)-1-nitrosourea by rat hepatic microsomes.
Topics: Animals; Carmustine; In Vitro Techniques; Kinetics; Lomustine; Male; Microsomes, Liver; NADP; Phenobarbital; Rats; Rats, Inbred F344 | 1981 |
Mechanism of action of (2-haloethyl)nitrosoureas on DNA. Isolation and reactions of postulated 2-(alkylimino)-3-nitrosooxazolidine intermediates in the decomposition of 1,3-bis(2-chloroethyl)-, 1-(2-chloroethyl)-3-cyclohexyl-, and 1-(2-chloroethyl)-3-(4'-
Topics: Alkylation; Antineoplastic Agents; Carmustine; Chemical Phenomena; Chemistry; DNA; Lomustine; Nitrosourea Compounds; Semustine | 1981 |
Analysis for nitrosourea antitumor agents by gas chromatography--mass spectrometry.
Topics: Animals; Antineoplastic Agents; Carmustine; Dogs; Gas Chromatography-Mass Spectrometry; Lomustine; Nitrosourea Compounds; Semustine | 1981 |
Nephrotoxicity of nitrosoureas.
Topics: Adolescent; Adult; Aged; Biopsy; Blood Urea Nitrogen; Brain Neoplasms; Carmustine; Child; Creatinine; Dose-Response Relationship, Drug; Female; Humans; Kidney; Kidney Diseases; Lomustine; Male; Middle Aged; Nitrosourea Compounds; Retrospective Studies; Semustine | 1981 |
Chronic toxicity and carcinogenicity of cytostatic N-nitroso-(2-chloroethyl) ureas after repeated intravenous application to rats.
Topics: Animals; Antineoplastic Agents; Carcinogens; Carmustine; Lomustine; Lung Neoplasms; Male; Neoplasms, Experimental; Nervous System Neoplasms; Nitrosourea Compounds; Rats; Rats, Inbred Strains; Semustine; Stomach Neoplasms | 1980 |
Metastatic tumor to the retina and vitreous cavity from primary melanoma of the skin: treatment with systemic and subconjunctival chemotherapy.
Topics: Adult; Carmustine; Dacarbazine; Eye Neoplasms; Female; Humans; Lomustine; Melanoma; Retina; Skin Neoplasms; Vitreous Body | 1981 |
Inhibition of tubulin polymerization by nitrosourea-derived isocyanates.
Topics: Animals; Brain; Carmustine; Cattle; Cyanates; Depression, Chemical; In Vitro Techniques; Lomustine; Microtubules; Nerve Tissue Proteins; Nitrosourea Compounds; Polymers; Swine; Tubulin | 1980 |
Lipophilic drugs and lipoproteins: partitioning effects on chloroethylnitrosourea reaction rates in serum.
Topics: Carmustine; Humans; In Vitro Techniques; Kinetics; Lipids; Lipoproteins; Lomustine; Models, Biological; Nitrosourea Compounds; Semustine; Solubility | 1980 |
Tumorigenic effect of topical mechlorethamine, BCNU and CCNU in mice.
Topics: Animals; Carcinogens; Carcinoma, Squamous Cell; Carmustine; Lomustine; Mechlorethamine; Mice; Neoplasms, Experimental; Nitrosourea Compounds; Papilloma; Skin Neoplasms | 1980 |
Distribution of Bratton-Marshall-positive material in mice following intravenous injections of nitrosoureas.
Topics: Animals; Biotransformation; Carmustine; Colorimetry; Injections, Intravenous; Lomustine; Mice; Nitrosourea Compounds; Semustine; Tissue Distribution | 1980 |
[Use of BCG as an immunoadjuvant in combination with antitumor agents in virus-induced leukemia].
Topics: Animals; Antineoplastic Agents; BCG Vaccine; Carmustine; Drug Synergism; Drug Therapy, Combination; Hybridization, Genetic; Leukemia, Experimental; Lomustine; Mice; Mice, Inbred BALB C; Mice, Inbred DBA; Moloney murine leukemia virus; Neoplasm Transplantation; Semustine; Time Factors | 1980 |
Cytotoxicity of fluoroethylating agents is potentiated by O6-benzylguanine.
Topics: Antineoplastic Agents; Antineoplastic Agents, Alkylating; Carmustine; Cell Survival; Drug Synergism; Guanine; HeLa Cells; Humans; Iodoacetamide; Lomustine; Nimustine | 1996 |
Quantitative DNA analysis of an intracerebrally transplanted brain tumour model after experimental chemotherapy with BCNU and CCNU.
Topics: Animals; Brain Neoplasms; Brain Tissue Transplantation; Carmustine; Cell Division; Cytophotometry; DNA, Neoplasm; Glioma; Lomustine; Neoplasm Transplantation; Rats; Rats, Inbred Strains; Transplantation, Isogeneic; Tumor Cells, Cultured | 1995 |
Radiation and chemotherapy improve outcome in oligodendroglioma.
Topics: Adolescent; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Carmustine; Child; Child, Preschool; Combined Modality Therapy; Female; Humans; Lomustine; Male; Middle Aged; Oligodendroglioma; Procarbazine; Radiotherapy Dosage; Vincristine | 1997 |
Induction of specific-locus and dominant lethal mutations in male mice by 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU) and 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea (CCNU).
Topics: Animals; Antineoplastic Agents, Alkylating; Carmustine; Female; Genes, Dominant; Genes, Lethal; Lomustine; Male; Mice; Mutagenesis; Mutagenicity Tests; Mutagens; Pregnancy; Spermatozoa | 1997 |
Role of O6-methylguanine-DNA methyltransferase in the resistance of pancreatic tumors to DNA alkylating agents.
Topics: Adenocarcinoma; Adult; Aged; Antineoplastic Agents, Alkylating; Apoptosis; Carmustine; Cell Survival; Drug Resistance, Neoplasm; Female; Humans; Lomustine; Male; Middle Aged; Mitosis; Neoplasm Staging; O(6)-Methylguanine-DNA Methyltransferase; Pancreatic Neoplasms; Streptozocin; Survival Rate; Tumor Cells, Cultured | 1997 |
Genotoxic effect of 4-aroyl-1-(2-chloroethyl)-1nitrosohydrazinecarboxamides on Saccharomyces cerevisiae cells.
Topics: Antineoplastic Agents; Carmustine; Hydrazines; Lomustine; Mutagenicity Tests; Nitrosourea Compounds; Saccharomyces cerevisiae | 1998 |
A retrospective study of the value of chemotherapy as adjuvant therapy to surgery and radiotherapy in grade 3 and 4 gliomas.
Topics: Administration, Oral; Adult; Age Distribution; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Carmustine; Chemotherapy, Adjuvant; Glioblastoma; Humans; Infusions, Intra-Arterial; Lomustine; Middle Aged; Procarbazine; Retrospective Studies; Survival Rate; Treatment Outcome; Vincristine | 1998 |
The minimum CD34 threshold depends on prior chemotherapy in autologous peripheral blood stem cell recipients.
Topics: Adolescent; Adult; Antigens, CD34; Antineoplastic Combined Chemotherapy Protocols; Blood Cell Count; Carmustine; Combined Modality Therapy; Female; Hematologic Neoplasms; Hematopoietic Stem Cell Mobilization; Hematopoietic Stem Cell Transplantation; Hematopoietic Stem Cells; Humans; Lomustine; Male; Mechlorethamine; Melphalan; Middle Aged; Transplantation, Autologous | 1999 |
High-dose BEAM chemotherapy with autologous haemopoietic stem cell transplantation for Hodgkin's disease is unlikely to be associated with a major increased risk of secondary MDS/AML.
Topics: Acute Disease; Adolescent; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Carmustine; Child; Child, Preschool; Chlorambucil; Cohort Studies; Combined Modality Therapy; Cytarabine; Doxorubicin; Etoposide; Female; Hematopoietic Stem Cell Transplantation; Hodgkin Disease; Humans; Incidence; Infant; Leukemia, Myeloid; Life Tables; Lomustine; Male; Mechlorethamine; Melphalan; Middle Aged; Myelodysplastic Syndromes; Neoplasms, Second Primary; Podophyllotoxin; Prednisolone; Prednisone; Procarbazine; Retrospective Studies; Risk; Salvage Therapy; Vinblastine; Vincristine | 1999 |
Procarbazine, lomustine, and vincristine (PCV) chemotherapy for anaplastic astrocytoma: A retrospective review of radiation therapy oncology group protocols comparing survival with carmustine or PCV adjuvant chemotherapy.
Topics: Adult; Aged; Analysis of Variance; Antineoplastic Combined Chemotherapy Protocols; Astrocytoma; Carmustine; Combined Modality Therapy; Female; Humans; Karnofsky Performance Status; Lomustine; Male; Middle Aged; Procarbazine; Randomized Controlled Trials as Topic; Retrospective Studies; Survival Analysis; Vincristine | 1999 |
Comparison of DNA lesions produced by tumor-inhibitory 1,2-bis(sulfonyl)hydrazines and chloroethylnitrosoureas.
Topics: Antineoplastic Agents, Alkylating; Bacteriophage T7; Carmustine; Cross-Linking Reagents; DNA; DNA Damage; DNA, Viral; Isocyanates; Lomustine; Semustine | 2000 |
Poly(ADP-ribose) polymerase-independent potentiation of nitrosourea cytotoxicity by 3-aminobenzamide in human malignant glioma cells.
Topics: Benzamides; Binding Sites; Carmustine; Cell Survival; Dose-Response Relationship, Drug; Drug Synergism; Enzyme Inhibitors; G2 Phase; Glioma; Humans; Lomustine; Methylnitrosourea; Mitosis; Nimustine; Nitrosourea Compounds; Poly(ADP-ribose) Polymerase Inhibitors; Poly(ADP-ribose) Polymerases; Tumor Cells, Cultured | 2000 |
Locally delivered chemotherapy and repeated surgery can improve survival in glioblastoma patients.
Topics: Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Brain Neoplasms; Carmustine; Chemotherapy, Adjuvant; Cisplatin; Combined Modality Therapy; Cranial Irradiation; Disease Progression; Disease-Free Survival; Drug Evaluation; Glioblastoma; Humans; Injections, Spinal; Lomustine; Middle Aged; Mitoxantrone; Neoplasm Recurrence, Local; Procarbazine; Radiotherapy, Adjuvant; Reoperation; Survival Analysis; Treatment Outcome; Vincristine | 1999 |
Effects of carmustine and lomustine on arylamine N-acetyltransferase activity and 2-aminofluorene-DNA adducts in rat glial tumor cells.
Topics: Animals; Arylamine N-Acetyltransferase; Brain Neoplasms; Carmustine; DNA Adducts; Fluorenes; Glioma; Kinetics; Lomustine; Rats; Tumor Cells, Cultured | 2000 |
Protection of hematopoietic cells from O(6)-alkylation damage by O(6)-methylguanine DNA methyltransferase gene transfer: studies with different O(6)-alkylating agents and retroviral backbones.
Topics: Alkylating Agents; Alkylation; Animals; Carmustine; Cells, Cultured; Colony-Forming Units Assay; Dacarbazine; DNA Damage; DNA, Complementary; Drug Resistance; Genetic Vectors; Hematopoietic Stem Cells; Humans; Lomustine; Mice; Moloney murine leukemia virus; Nimustine; O(6)-Methylguanine-DNA Methyltransferase; Recombinant Fusion Proteins; Retroviridae; Sarcoma Viruses, Murine; Spleen Focus-Forming Viruses; Temozolomide; Terminal Repeat Sequences; Transfection | 2001 |
Combination chemotherapy with carmustine and cisplatin followed by procarbazine, lomustine, and vincristine for adult high-grade astrocytoma.
Topics: Adolescent; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Astrocytoma; Brain Neoplasms; Carmustine; Cisplatin; Female; Glioblastoma; Humans; Lomustine; Male; Middle Aged; Procarbazine; Vincristine | 2005 |
Nitrosourea efficacy in high-grade glioma: a survival gain analysis summarizing 504 cohorts with 24193 patients.
Topics: Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Astrocytoma; Brain Neoplasms; Carmustine; Clinical Trials as Topic; Cohort Studies; Data Interpretation, Statistical; Databases, Factual; Female; Glioblastoma; Glioma; Humans; Lomustine; Male; Nimustine; Nitrosourea Compounds; Reproducibility of Results; Selection Bias; Survival Analysis; Treatment Outcome | 2008 |
High-dose chemotherapy with autologous stem cell transplantation in adults with recurrent embryonal tumors of the central nervous system.
Topics: Adult; Antineoplastic Agents; Antineoplastic Agents, Alkylating; Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Carmustine; Central Nervous System Neoplasms; Cisplatin; Cohort Studies; Disease Progression; Etoposide; Female; Follow-Up Studies; Humans; Lomustine; Male; Medulloblastoma; Middle Aged; Neoadjuvant Therapy; Neoplasm Recurrence, Local; Procarbazine; Retrospective Studies; Stem Cell Transplantation; Survival Rate; Thiotepa; Transplantation, Autologous | 2008 |
[Chemotherapy and renal toxicity].
Topics: Angiogenesis Inhibitors; Antineoplastic Agents; Carboplatin; Carmustine; Cisplatin; Deoxycytidine; Gemcitabine; Humans; Kidney; Kidney Diseases; Lomustine; Methotrexate; Organoplatinum Compounds; Oxaliplatin | 2008 |
[Clinical features and combined treatment of the central nervous system in Hodgkin's disease].
Topics: Adolescent; Adult; Antineoplastic Agents, Alkylating; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Carmustine; Chemotherapy, Adjuvant; Child; Female; Hodgkin Disease; Humans; Lomustine; Male; Methylnitrosourea; Middle Aged; Prognosis; Radiotherapy, Adjuvant; Retrospective Studies; Risk Factors; Spinal Cord Compression; Survival Analysis; Treatment Outcome; Young Adult | 2008 |
[Retrospective analysis of 24 recurrent glioblastoma after chemoradiation and treated with nitrosoureas or irinotecan and bevacizumab].
Topics: Adult; Aged; Angiogenesis Inhibitors; Antibodies, Monoclonal, Humanized; Antineoplastic Combined Chemotherapy Protocols; Bevacizumab; Brain Neoplasms; Camptothecin; Carmustine; Chemoradiotherapy; Chemotherapy, Adjuvant; Cohort Studies; Dacarbazine; Drug Therapy, Combination; Glioblastoma; Humans; Irinotecan; Lomustine; Middle Aged; Neoplasm Recurrence, Local; Nitrosourea Compounds; Radiation-Sensitizing Agents; Retrospective Studies; Temozolomide | 2012 |
Prolonged survival associated with the use of intraoperative carmustine (Gliadel) in a paediatric patient with recurrent grade III astrocytoma.
Topics: Adolescent; Antineoplastic Agents; Antineoplastic Agents, Alkylating; Astrocytoma; Carmustine; Combined Modality Therapy; Drug Implants; Female; Humans; Lomustine; Neoplasm Recurrence, Local; Procarbazine; Time Factors; Treatment Outcome | 2013 |
Retrospective study of carmustine or lomustine with bevacizumab in recurrent glioblastoma patients who have failed prior bevacizumab.
Topics: Adult; Aged; Antibodies, Monoclonal, Humanized; Antineoplastic Combined Chemotherapy Protocols; Bevacizumab; Brain Neoplasms; Carmustine; Drug Resistance, Neoplasm; Female; Follow-Up Studies; Glioblastoma; Humans; Lomustine; Male; Middle Aged; Neoplasm Recurrence, Local; Neoplasm Staging; Prognosis; Retrospective Studies; Salvage Therapy; Survival Rate; Young Adult | 2014 |
LACE versus BEAM conditioning in relapsed and refractory lymphoma transplant: retrospective multicenter analysis of toxicity and efficacy.
Topics: Adolescent; Adult; Autografts; Carmustine; Child; Child, Preschool; Cohort Studies; Cyclophosphamide; Cytarabine; Etoposide; Female; Hematopoietic Stem Cell Transplantation; Hodgkin Disease; Humans; Lomustine; Lymphoma, Non-Hodgkin; Male; Melphalan; Middle Aged; Multicenter Studies as Topic; Retrospective Studies; Survival Rate; Transplantation Conditioning; Young Adult | 2016 |
A retrospective comparison of toxicity and initial efficacy of two autologous stem cell transplant conditioning regimens for relapsed lymphoma: LEAM and BEAM.
Topics: Antineoplastic Combined Chemotherapy Protocols; Carmustine; Cytarabine; Etoposide; Female; Hematopoietic Stem Cell Transplantation; Humans; Lomustine; Lymphoma; Male; Melphalan; Middle Aged; Retrospective Studies; Salvage Therapy; Survival Analysis; Transplantation Conditioning; Transplantation, Autologous | 2016 |
Substituting carmustine for lomustine is safe and effective in the treatment of relapsed or refractory Lymphoma-a retrospective study from the BSBMT (BEAM versus LEAM).
Topics: Antineoplastic Combined Chemotherapy Protocols; Carmustine; Cytarabine; Etoposide; Humans; Lomustine; Lymphoma; Melphalan; Retrospective Studies; Transplantation Conditioning; Transplantation, Autologous | 2021 |
CRISPR/Cas9-induced knockout reveals the role of ABCB1 in the response to temozolomide, carmustine and lomustine in glioblastoma multiforme.
Topics: ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Carmustine; Cell Line, Tumor; CRISPR-Cas Systems; Drug Resistance, Neoplasm; Glioblastoma; Humans; Lomustine; Neoplasm Proteins; Temozolomide | 2022 |