Compounds > carmustine

carmustine and guanine

carmustine has been researched along with guanine in 138 studies

Research

Studies (138)

TimeframeStudies, this research(%)All Research%
pre-199012 (8.70)18.7374
1990's57 (41.30)18.2507
2000's59 (42.75)29.6817
2010's10 (7.25)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Bigner, DD; Dolan, ME; Felker, GM; Friedman, HS; Moschel, RC; Pegg, AE; Rich, J; Schold, SC1
Berger, MS; Bobola, MS; Ewers, TG; Muramoto, M; Silber, JR1
Arce, C; Berger, NA; Gerson, SL; Petzold, SJ; Willson, JK1
Dolan, ME; Mitchell, RB; Moschel, RC; Mummert, C; Pegg, AE1
Dolan, ME; Mitchell, RB; Moschel, RC1
Elksne, SJ; Gorbacheva, LB; Kukushkina, GV; Miniker, TD; Preobrazhenskaya, MN1
Brent, TP; Gonzaga, PE; Harris, L; Margison, GP1
Eberle, G; Huh, NH; Nehls, P; Rajewsky, MF; Thomale, J1
Anderson, SP; Briscoe, WT; May, HE1
Barnes, DM; Erickson, LC; Fisher, RI; Futscher, BW; Micetich, KC1
Gerson, SL; Trey, JE2
Clyde, C; Dolan, ME; Erickson, LC; Hora, NK; Norbeck, L; Pegg, AE1
Barrows, LR; Borchers, AH; Paxton, MB1
Gralla, JD; Poljak, LG; Sasse-Dwight, S1
Briscoe, WT; Duarte, SP1
Aida, T; Berger, MS; Bodell, WJ; Rosenblum, ML2
Cleaver, JE1
Kirk, MC; Ludlum, DB; Tong, WP1
Ludlum, DB; Tong, WP1
Chae, MY; Dolan, ME; Moschel, RC; Pegg, AE; Swenn, K1
Gerson, SL; Willson, JK1
Magull-Seltenreich, A; Zeller, WJ2
Bigner, DD; Catino, JJ; Dolan, ME; Friedman, HS; Keir, S; Marcelli, S; Pegg, AE; Schold, SC1
Dolan, ME; Erickson, LC; Marathi, UK2
Dolan, ME; Flora, KP; Friedman, HS; Grever, MR; Moschel, RC; Pegg, AE; Vishnuvajjala, BR1
Buschfort, C; Müller, MR; Rajewsky, MF; Seeber, S; Seiler, F; Thomale, J1
Berger, SJ; Donovan, C; Gerson, SL; Varnes, ME1
Dolan, ME; Felker, GM; Friedman, HS; Moschel, RC; Schold, C1
Deen, DF; Dolan, ME; Gonzalez, GG; Marton, LJ; Pegg, AE; Sarkar, A1
Dolan, ME; Grindey, GB; Moschel, RC; Pegg, AE1
Dolan, ME; Erickson, LC; Kroes, RA; Marathi, UK1
Gerson, SL; Gordon, NH; Norton, K; Willson, JK; Zborowska, E1
Biser, ND; Dolan, ME; English, HF; Moschel, RC; Pegg, AE1
Chen, JM; Ikenaga, M; Moschel, RC; Zhang, YP1
Ali-Osman, F; Friedman, HS; Srivenugopal, KS; Yuan, XH1
May, BL; Newlands, ES; Porteus, JK; Wedge, SR1
Loktionova, NA; Pegg, AE1
Gerson, SL; Lee, K; Liu, L; Wasan, E1
Newlands, ES; Wedge, SR1
Ali-Osman, F; Bigner, DD; Elion, GB; Friedman, HS; Keir, S; Marcelli, S; Moynihan, K1
Donovan, C; Dumenco, LL; Gerson, SL; Kastan, M; Phillips, W1
Kohda, K; Terashima, I1
Newlands, ES; Porteous, JK; Wedge, SR1
Allay, JA; Gerson, SL; Koç, ON; Lee, KM; Liu, L; Phillips, WP; Reese, JS1
Gerson, SL; Liu, L; Markowitz, S1
Archer, GE; Bigner, DD; Dolan, ME; Friedman, HS; Kurpad, SN; McLendon, RE; Moschel, RC; Pegg, AE1
Ashby, J; Chinnasamy, N; Dexter, TM; Fairbairn, LJ; Hickson, I; Margison, GP; Rafferty, JA; Tinwell, H1
Edgren, MR; Egyházi, S; Hansson, J; Kröckel, D; Mannervik, B; Ringborg, U1
Gerson, SL; Gordon, NH; Liu, L; Markowitz, SD; Phillips, WP; Willson, JK; Zaidi, NH; Zborowska, E1
Davis, BM; Gerson, SL; Koç, ON; Lee, K; Reese, JS; Schupp, JE1
Allan, JM; Dreslin, AJ; Engelward, BP; Samson, LD; Tomasz, M; Wyatt, MD1
Buschfort, C; Lensing, C; Müller, MR; Rajewsky, MF; Seeber, S; Thomale, J1
Brent, TP; Harris, LC; Marathi, UK; Venable, CC1
Dolan, ME; Pegg, AE1
Brent, TP; Edwards, CC; Harris, LC; Houghton, PJ; Marathi, UK; Sorrentino, BP; Srivastava, DK; Vanin, EF1
Davis, BM; Gerson, SL; Liu, L; Reese, JS1
Bibby, MC; Margison, GP; McElhinney, RS; Rafferty, JA; Thompson, MJ1
Davis, BM; Gerson, SL; Koç, ON; Liu, L; Majczenko, KJ; Reese, JS1
Gerson, SL; Haaga, J; Hoppel, CL; Ingalls, ST; Liu, L; Majka, S; Pluda, JM; Spiro, TP; Willson, JK1
Crone, TM; Kanugula, S; Loktionova, NA; Pegg, AE; Xu-Welliver, M2
Gerson, SL; Phillips, WP1
Hickman, MJ; Samson, LD1
Chinnasamy, D; Chinnasamy, N; Dexter, T; Fairbairn, L; Lashford, L; Margison, G; Rafferty, J; Thatcher, N1
Erickson, LC; Kreklau, EL; Kurpad, C; Williams, DA1
Davis, BM; Gerson, SL; Liu, L; Pegg, AE; Roth, JC; Xu-Welliver, M1
Kokkinakis, DM; Moschel, RC; Pegg, AE; Schold, SC1
Davis, BM; Gerson, SL; Koç, ON1
Bigner, DD; Dolan, ME; Friedman, HS; Keir, ST; Lawless, A; Moschel, RC; Pegg, AE1
Abdul-Rahman, S; Baker, TG; Bibby, MC; Margison, GP; Rafferty, JA; Thompson, MJ1
Gao, H; Lu, H; Wan, Y; Wu, D1
Erickson, LC; Kurpad, C; Maze, R; Pegg, A; Williams, DA1
Friedman, HS1
Bertucci, D; Dolan, ME; Ewesuedo, RB; Mani, S; Ratain, MJ; Schilsky, RL; Vogelzang, NJ; Wilson, LR1
Bailey, J; Chandra, S; Cooper, R; D'Souza, M; Pegg, AE; Ragg, S; Seshadri, R; Williams, DA; Xu-Welliver, M1
Ashley, DM; Bigner, DD; Cokgor, I; Colvin, OM; Dolan, ME; Ewesuedo, RB; Friedman, AH; Friedman, HS; Garcia-Turner, AM; Haglund, MM; Herndon, JE; Long, L; McLendon, RE; Moschel, RC; Pegg, AE; Pluda, J; Provenzale, JM; Quinn, JA; Rich, JN; Sampson, J; Stewart, ES; Tourt-Uhlig, S1
Cai, Y; Dolan, ME; Ludeman, SM; Pegg, AE; Wu, MH; Xu-Welliver, M1
Brem, H; Dolan, ME; Rhines, LD; Sampath, P; Tyler, BM; Weingart, J1
Goodtzova, K; Kanugula, S; Loktionova, NA; Moschel, RC; Pauly, GT; Pegg, AE1
Bocangel, DB; Kokkinakis, DM; Moschel, RC; Pegg, AE; Schold, SC1
Christians, FC; Davis, BM; Encell, LP; Friebert, SE; Gerson, SL; Liu, L; Loeb, LA; Zielske, SP1
Blokland, I; Boudewijn, A; Down, JD; Margison, GP; McGown, AT; Ploemacher, RE; Watson, AJ; Westerhof, GR; Wood, M1
Bodell, WJ; Giannini, DD; Hassenbusch, S; Levin, VA1
Berger, NA; Berger, SJ; Dowlati, A; Gerson, SL; Haaga, J; Liu, L; Remick, SC; Spiro, TP; Willson, JK1
Gerson, SL; Koç, ON; Lee, K; Maitra, B1
Bodell, WJ; Dhananjaya, N; Giannini, DD; Miller, DL; Sprung, CN; Wang, YP1
Dolan, ME; Long, L1
Bigner, DD; Colvin, OM; Delaney, S; Dolan, ME; Friedman, AH; Friedman, HS; Gururangan, S; Haglund, MM; Herndon, JE; Kaplan, R; McLendon, RE; Moschel, RC; Pegg, AE; Pluda, J; Provenzale, JM; Quinn, JA; Reardon, DA; Rich, JN; Sampson, JH; Tourt-Uhlig, S1
Chen, Z; Ruan, CG; Wang, J; Xia, X1
Davis, BM; Gerson, SL; Liu, L; Schwartz, S1
Biser-Rohrbaugh, A; Bunton, TE; Carson, BS; Gabikian, P; Guarnieri, M; Tyler, BM; Weingart, J; Wu, QZ1
Bigner, DD; Colvin, OM; Dolan, ME; Friedman, HS; Houghton, PJ; Keir, S; Moschel, RC; Pegg, AE1
Bodell, WJ; Giannini, DD; Levin, VA; Pietronigro, D; Singh, S1
Bowman, JE; Gerson, SL; Lingas, KT; Reese, JS1
Boczko, EM; Gerson, SL; Hoppel, CL; Ingalls, ST; Li, X; Majka, S; Spiro, TP; Tserng, KY; Willson, JK1
Cupissol, D; Cuq, P; Depeille, P; Evrard, A; Montero, JL; Passagne, I; Vian, L; Winum, JY1
Ahmed, MM; Chendil, D; Kokkinakis, DM; Moschel, RC; Pegg, AE1
Donze, JR; Gerson, SL; Lingas, KT; Reese, JS; Zielske, SP1
Bailey, BJ; Erickson, LC; Hartwell, JR; Kreklau, EL; Liu, N; Pollok, KE; Williams, DA1
Davis, BM; Dropulic, B; Humeau, L1
Dunkel, IJ; Edgar, MA; Mark, EB; Occhiogrosso, G; Souweidane, MM1
Cario-André, M; de Verneuil, H; Ged, C; Géronimi, F; Gerson, SL; Moreau-Gaudry, F; Richard, E; Robert, E1
Bacolod, MD; Bigner, DD; Bullock, NS; Colvin, OM; Dolan, ME; Fang, Q; Friedman, HS; Johnson, SP; Modrich, P; Moschel, RC; Pegg, AE1
Loktionova, NA; Moschel, RC; Pegg, AE; Wei, G1
Donze, JR; Liu, L; Yan, L1
Blank, A; Bobola, MS; Ellenbogen, RG; Geyer, JR; Goff, RD; Silber, JR1
Cai, S; Cooper, RJ; Ferkowicz, MJ; Hartwell, JR; Kelley, MR; Pollok, KE; Xu, Y1
Cherian, MM; Delaney, SM; Dolan, ME; Hansen, RJ; Kogan, SC; Lin, S; Nagasubramanian, R1
Dolan, E; Gajewski, TF; Gerson, SL; Lin, S; Liu, L; Sosman, J; Vokes, EE1
Covas, DT; Davis, BM; Encell, LP; Fontes, AM; Gerson, SL; Lingas, K; Loeb, LA; Pegg, AE; Zago, MA1
Agamah, ES; Brockstein, BB; Delaney, SM; Dolan, ME; McLendon, R; Ryan, CW; Samuels, BL; Vokes, EE1
Bodell, AP; Bodell, WJ; Giannini, DD1
Delaney, SM; Dolan, ME; Hansen, RJ; Nagasubramanian, R; Samson, LD1
Chen, CC; D'Andrea, A; Taniguchi, T1
Carson, KA; Delaney, SM; Dolan, ME; Fisher, JD; Grossman, SA; Judy, K; Olivi, A; Rosenblum, ML; Tatter, SB; Weingart, J1
Bahlis, N; Batts, ED; Fu, P; Gerson, SL; Kane, D; Liu, L; Maisel, C; O'Brien, T; Remick, S1
Ball, CR; Fessler, S; Glimm, H; Pilz, IH; Schmidt, M; von Kalle, C; Williams, DA1
Fang, Q; Javanmard, S; Loktionova, NA; Moschel, RC; Pauly, GT; Pegg, AE1
Adams, DM; Berg, SL; Bernstein, M; Blaney, SM; Neville, K; Zhou, T1
Ogawa, M; Ueda, T; Yamauchi, T1
Benhattar, J; Bernasconi, CC; Bricod, C; Gros, S; Janzer, RC; Juillerat-Jeanneret, L; Trepey, S1
Bigner, DD; Carter, J; Desjardins, A; Friedman, AH; Friedman, HS; Gururangan, S; Herndon, JE; Jiang, SX; McLendon, RE; Quinn, JA; Reardon, DA; Rich, JN; Sampson, JH; Threatt, S; Vredenburgh, JJ1
Alexander, IE; Gunning, PW; Hardeman, EC; Hook, J; Joya, JE; Kahatapitiya, P; Kramer, B; Lee, AS; Liu, R; McCowage, G; Montarras, D; Schevzov, G1
Choi, U; Clevenger, JR; Donahue, RE; Dunbar, CE; Kang, E; Krouse, A; Larochelle, A; Loktionova, NA; Malech, HL; Metzger, M; Naumann, N; Persons, D; Shou, Y; Sorrentino, BP; Stewart, C1
Cruz-Vallejo, VL; Morales-Ramírez, P; Vallarino-Kelly, T1
Adair, JE; Beard, BC; Ironside, C; Kiem, HP; McCune, JS; Trobridge, GD1
Baumann, RP; Ishiguro, K; Penketh, PG; Sartorelli, AC; Shyam, K; Zhu, YL1
Apisarnthanarax, N; Carlson, S; Chan, DV; Cooper, KD; Fu, P; Gerson, SL; Gilliam, AC; Liu, L; Remick, SC; Stevens, SR; Szabo, SK; Wood, GS1
Balabanov, S; Bokemeyer, C; Braig, M; Hagel, C; Hauber, J; Lamszus, K; Pällmann, N; Preukschas, M; Schulte, A; Sievert, H; Weber, K1
Huang, F; Jiang, Y; Pei, Y; Qian, L; Tang, Y; Wang, K; Zhang, H; Zhang, X; Zheng, J1
Adair, JE; Baldock, AL; Beard, BC; Born, DE; Bridge, CA; Gonzalez-Cuyar, LF; Gori, JL; Guyman, LA; Hawkins-Daarud, A; Johnston, SK; Kiem, HP; Mrugala, MM; Rockhill, JK; Rockne, RC; Silbergeld, DL; Storer, BE; Swanson, KR1
Blumenthal, DT; Moore, DF; Padula, GD; Rankin, C; Rushing, EJ; Schulman, SB; Sloan, AE; Spence, AM; Stelzer, KJ; Wade, ML1
Jiang, Y; Li, X; Liu, C; Wang, F; Yao, S1
Carlson, S; Chan, DV; Cooper, KD; Dowlati, A; Fu, P; Gerson, SL; Groft, S; Honda, K; Lu, K; McCormick, TS; Rosenjack, J; Tacastacas, JD1

Reviews

2 review(s) available for carmustine and guanine

ArticleYear
O6-alkylguanine-DNA alkyltransferase. A target for the modulation of drug resistance.
    Hematology/oncology clinics of North America, 1995, Volume: 9, Issue:2

    Topics: Alkylating Agents; Biological Transport; Carmustine; Clinical Trials as Topic; DNA Damage; DNA Repair; DNA, Neoplasm; Drug Resistance; Guanine; Humans; Inactivation, Metabolic; Methyltransferases; Neoplasm Proteins; Neoplasms; O(6)-Methylguanine-DNA Methyltransferase

1995
O6-benzylguanine and its role in chemotherapy.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 1997, Volume: 3, Issue:6

    Topics: Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Carmustine; DNA Repair; Enzyme Inhibitors; Guanine; Humans; Neoplasms; O(6)-Methylguanine-DNA Methyltransferase; Transplantation, Heterologous

1997

Trials

15 trial(s) available for carmustine and guanine

ArticleYear
O6-benzylguanine: a clinical trial establishing the biochemical modulatory dose in tumor tissue for alkyltransferase-directed DNA repair.
    Cancer research, 1999, May-15, Volume: 59, Issue:10

    Topics: Adult; Aged; Antineoplastic Agents, Alkylating; Biopsy; Biotransformation; Breast Neoplasms; Carmustine; Digestive System Neoplasms; DNA Repair; DNA, Neoplasm; Drug Resistance, Neoplasm; Female; Guanine; Humans; Lung Neoplasms; Male; Middle Aged; Neoplasm Proteins; Neoplasms; O(6)-Methylguanine-DNA Methyltransferase; Prodrugs; Safety; Tomography, X-Ray Computed

1999
Phase I clinical and pharmacological study of O6-benzylguanine followed by carmustine in patients with advanced cancer.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2000, Volume: 6, Issue:8

    Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Carmustine; Dose-Response Relationship, Drug; Female; Guanine; Humans; Male; Middle Aged; Neoplasms; O(6)-Methylguanine-DNA Methyltransferase

2000
Phase I trial of carmustine plus O6-benzylguanine for patients with recurrent or progressive malignant glioma.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2000, Oct-15, Volume: 18, Issue:20

    Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Astrocytoma; Carmustine; Central Nervous System Neoplasms; Drug Administration Schedule; Glioblastoma; Guanine; Humans; Middle Aged; Neoplasm Recurrence, Local

2000
Phase II trial of carmustine plus O(6)-benzylguanine for patients with nitrosourea-resistant recurrent or progressive malignant glioma.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2002, May-01, Volume: 20, Issue:9

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Area Under Curve; Brain Neoplasms; Carmustine; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Resistance, Neoplasm; Female; Glioma; Guanine; Humans; Male; Middle Aged; Nitrosourea Compounds; Treatment Outcome

2002
Pharmacokinetics of O6-benzylguanine (NSC637037) and its metabolite, 8-oxo-O6-benzylguanine.
    Journal of clinical pharmacology, 2003, Volume: 43, Issue:8

    Topics: Aged; Antineoplastic Agents, Alkylating; Carmustine; Enzyme Inhibitors; Female; Guanine; Half-Life; Humans; Infusions, Intravenous; Male; Metabolic Clearance Rate; Middle Aged; Models, Biological; Neoplasms; O(6)-Methylguanine-DNA Methyltransferase

2003
Phase II trial of the O6-alkylguanine DNA alkyltransferase inhibitor O6-benzylguanine and 1,3-bis(2-chloroethyl)-1-nitrosourea in advanced melanoma.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2005, Nov-01, Volume: 11, Issue:21

    Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Antineoplastic Agents, Alkylating; Antineoplastic Combined Chemotherapy Protocols; Carbon Monoxide; Carmustine; Cohort Studies; Disease Progression; Female; Guanine; Humans; Leukocytes, Mononuclear; Male; Melanoma; Middle Aged; Neoplasm Metastasis; O(6)-Methylguanine-DNA Methyltransferase; Time Factors; Treatment Outcome

2005
A phase II trial of O6-benzylguanine and carmustine in patients with advanced soft tissue sarcoma.
    Cancer chemotherapy and pharmacology, 2006, Volume: 58, Issue:5

    Topics: Adult; Aged; Anemia; Antineoplastic Combined Chemotherapy Protocols; Carmustine; Enzyme Inhibitors; Female; Gastrointestinal Stromal Tumors; Guanine; Humans; Immunohistochemistry; Infant; Injections, Intravenous; Leiomyosarcoma; Male; Middle Aged; O(6)-Methylguanine-DNA Methyltransferase; Sarcoma; Survival Analysis; Tachycardia, Supraventricular; Thrombocytopenia; Treatment Outcome

2006
Phase I trial of polifeprosan 20 with carmustine implant plus continuous infusion of intravenous O6-benzylguanine in adults with recurrent malignant glioma: new approaches to brain tumor therapy CNS consortium trial.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2007, Feb-01, Volume: 25, Issue:4

    Topics: Adult; Aged; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Carmustine; Drug Delivery Systems; Female; Glioma; Guanine; Humans; Infusions, Intravenous; Male; Middle Aged; Neoplasm Recurrence, Local; O(6)-Methylguanine-DNA Methyltransferase

2007
O6-benzylguanine and BCNU in multiple myeloma: a phase II trial.
    Cancer chemotherapy and pharmacology, 2007, Volume: 60, Issue:3

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Carmustine; DNA; Drug Administration Schedule; Female; Follow-Up Studies; Guanine; Humans; Male; Middle Aged; Multiple Myeloma; Patient Selection; Reference Values

2007
Phase 1 trial of O6-benzylguanine and BCNU in children with CNS tumors: a Children's Oncology Group study.
    Pediatric blood & cancer, 2008, Volume: 50, Issue:3

    Topics: Adolescent; Antineoplastic Agents, Alkylating; Antineoplastic Combined Chemotherapy Protocols; Bone Marrow Diseases; Carmustine; Central Nervous System Neoplasms; Child; Child, Preschool; Cohort Studies; Combined Modality Therapy; DNA Repair; DNA, Neoplasm; Enzyme Inhibitors; Female; Guanine; Humans; Male; Maximum Tolerated Dose; Neoplasm Proteins; O(6)-Methylguanine-DNA Methyltransferase; Salvage Therapy

2008
Phase II trial of Gliadel plus O6-benzylguanine in adults with recurrent glioblastoma multiforme.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2009, Feb-01, Volume: 15, Issue:3

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Carmustine; Decanoic Acids; Female; Glioblastoma; Guanine; Humans; Male; Middle Aged; O(6)-Methylguanine-DNA Methyltransferase; Polyesters; Recurrence; Survival Analysis

2009
Phase I clinical trial of O6-benzylguanine and topical carmustine in the treatment of cutaneous T-cell lymphoma, mycosis fungoides type.
    Archives of dermatology, 2012, Volume: 148, Issue:5

    Topics: Administration, Topical; Adult; Aged; Aged, 80 and over; Antineoplastic Agents, Alkylating; Biomarkers, Tumor; Biopsy; Carmustine; Dose-Response Relationship, Drug; Drug Therapy, Combination; Enzyme Inhibitors; Female; Follow-Up Studies; Guanine; Humans; Infusions, Intravenous; Male; Middle Aged; Mycosis Fungoides; O(6)-Methylguanine-DNA Methyltransferase; Skin Neoplasms; Treatment Outcome

2012
Gene therapy enhances chemotherapy tolerance and efficacy in glioblastoma patients.
    The Journal of clinical investigation, 2014, Volume: 124, Issue:9

    Topics: Adult; Bone Marrow; Brain Neoplasms; Carmustine; Combined Modality Therapy; Dacarbazine; DNA Modification Methylases; DNA Repair Enzymes; Drug Resistance, Neoplasm; Female; Genetic Therapy; Glioblastoma; Guanine; Hematopoietic Stem Cell Transplantation; Humans; Male; Middle Aged; Models, Biological; Prospective Studies; Temozolomide; Tumor Suppressor Proteins

2014
A Phase III study of radiation therapy (RT) and O⁶-benzylguanine + BCNU versus RT and BCNU alone and methylation status in newly diagnosed glioblastoma and gliosarcoma: Southwest Oncology Group (SWOG) study S0001.
    International journal of clinical oncology, 2015, Volume: 20, Issue:4

    Topics: Adult; Aged; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Carmustine; Combined Modality Therapy; DNA Methylation; Female; Glioblastoma; Gliosarcoma; Guanine; Humans; Male; Middle Aged; Radiotherapy; Young Adult

2015
Evaluation of O6-Benzylguanine-Potentiated Topical Carmustine for Mycosis Fungoides: A Phase 1-2 Clinical Trial.
    JAMA dermatology, 2017, 05-01, Volume: 153, Issue:5

    Topics: Administration, Cutaneous; Administration, Intravenous; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Carmustine; Female; Guanine; Hospitals, University; Humans; Lymphoma, T-Cell, Cutaneous; Male; Maximum Tolerated Dose; Middle Aged; Mycosis Fungoides; Neoplasm Staging; O(6)-Methylguanine-DNA Methyltransferase; Skin Neoplasms; Treatment Outcome

2017

Other Studies

121 other study(ies) available for carmustine and guanine

ArticleYear
Enhancement of nitrosourea activity in medulloblastoma and glioblastoma multiforme.
    Journal of the National Cancer Institute, 1992, Dec-16, Volume: 84, Issue:24

    Topics: Animals; Carmustine; Drug Resistance; Female; Glioblastoma; Guanine; Humans; Male; Medulloblastoma; Methyltransferases; Mice; Mice, Inbred BALB C; Neoplasm Transplantation; O(6)-Methylguanine-DNA Methyltransferase; Streptozocin; Transplantation, Heterologous

1992
O6-alkylguanine DNA-alkyltransferase is not a major determinant of sensitivity to 1,3-bis(2-chloroethyl)-1-nitrosourea in four medulloblastoma cell lines.
    Oncology research, 1992, Volume: 4, Issue:6

    Topics: Carmustine; Cell Survival; Cerebellar Neoplasms; Drug Resistance; Guanine; Humans; Medulloblastoma; Methyltransferases; O(6)-Methylguanine-DNA Methyltransferase; Tumor Cells, Cultured

1992
Modulation of nitrosourea resistance in human colon cancer by O6-methylguanine.
    Biochemical pharmacology, 1992, Mar-03, Volume: 43, Issue:5

    Topics: Carmustine; Colonic Neoplasms; DNA Repair; Drug Resistance; Guanine; Humans; Methyltransferases; O(6)-Methylguanine-DNA Methyltransferase; Tumor Cells, Cultured

1992
Effect of O6-benzylguanine analogues on sensitivity of human tumor cells to the cytotoxic effects of alkylating agents.
    Cancer research, 1991, Jul-01, Volume: 51, Issue:13

    Topics: Alkylating Agents; Antineoplastic Agents; Carmustine; Cell Survival; Cisplatin; Cyclophosphamide; DNA; DNA Damage; Drug Synergism; Guanine; Humans; In Vitro Techniques; Lomustine; Mesylates; Methyltransferases; O(6)-Methylguanine-DNA Methyltransferase; Streptozocin; Tumor Cells, Cultured

1991
Effect of O6-benzylguanine on the sensitivity of human tumor xenografts to 1,3-bis(2-chloroethyl)-1-nitrosourea and on DNA interstrand cross-link formation.
    Cancer research, 1992, Mar-01, Volume: 52, Issue:5

    Topics: Animals; Carmustine; Colonic Neoplasms; DNA; DNA, Neoplasm; DNA, Single-Stranded; Drug Resistance; Drug Screening Assays, Antitumor; Drug Synergism; Female; Guanine; Humans; Lomustine; Mice; Mice, Nude; Transplantation, Heterologous; Tumor Cells, Cultured

1992
O6-methylguanine as a modulator of antitumor activity of N-alkyl-N-nitrosoureas in vivo.
    Anti-cancer drugs, 1991, Volume: 2, Issue:2

    Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Carmustine; DNA Damage; DNA, Neoplasm; Drug Interactions; Drug Resistance; Guanine; Leukemia L1210; Methylnitrosourea; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Neoplasm Transplantation; Nucleic Acid Conformation; Time Factors

1991
Evidence that covalent complex formation between BCNU-treated oligonucleotides and E. coli alkyltransferases requires the O6-alkylguanine function.
    Nucleic acids research, 1990, Jul-11, Volume: 18, Issue:13

    Topics: Base Sequence; Carmustine; Electrophoresis, Polyacrylamide Gel; Escherichia coli; Guanine; Humans; Methyltransferases; Molecular Sequence Data; O(6)-Methylguanine-DNA Methyltransferase; Oligodeoxyribonucleotides

1990
Repair of O6-ethylguanine in DNA protects rat 208F cells from tumorigenic conversion by N-ethyl-N-nitrosourea.
    Proceedings of the National Academy of Sciences of the United States of America, 1990, Volume: 87, Issue:24

    Topics: Animals; Carmustine; Cell Line; Cell Survival; Cell Transformation, Neoplastic; Clone Cells; DNA; DNA Repair; Ethylnitrosourea; Guanine; Kinetics; Methyltransferases; O(6)-Methylguanine-DNA Methyltransferase; Rats

1990
Base sequence specificity of three 2-chloroethylnitrosoureas.
    Biochemical pharmacology, 1990, Sep-15, Volume: 40, Issue:6

    Topics: Alkylation; Base Sequence; Carmustine; Chemical Phenomena; Chemistry; Chromatography, High Pressure Liquid; DNA; Guanine; Lomustine; Nitrosourea Compounds; Semustine; Structure-Activity Relationship

1990
Inhibition of a specific DNA repair system and nitrosourea cytotoxicity in resistant human cancer cells.
    Cancer communications, 1989, Volume: 1, Issue:1

    Topics: Carmustine; Cell Line; Cell Survival; DNA Probes; DNA Repair; DNA, Neoplasm; Drug Resistance; Guanine; Humans; Methyltransferases; O(6)-Methylguanine-DNA Methyltransferase; Restriction Mapping; Streptozocin; Tumor Cells, Cultured; Tumor Stem Cell Assay

1989
The role of O6-alkylguanine DNA alkyltransferase in limiting nitrosourea-induced sister chromatid exchanges in proliferating human lymphocytes.
    Cancer research, 1989, Apr-15, Volume: 49, Issue:8

    Topics: Carmustine; Cell Cycle; DNA Damage; DNA Repair; Guanine; Humans; Lymphocyte Activation; Lymphocytes; Methyltransferases; O(6)-Methylguanine-DNA Methyltransferase; Phytohemagglutinins; Sister Chromatid Exchange

1989
Expression of mammalian O6-alkylguanine-DNA alkyltransferase in a cell line sensitive to alkylating agents.
    Carcinogenesis, 1989, Volume: 10, Issue:9

    Topics: Alkylating Agents; Animals; Carmustine; Cell Division; Cell Line; Cricetinae; Cricetulus; Female; Guanine; Kinetics; Lomustine; Methylnitronitrosoguanidine; Methylnitrosourea; Methyltransferases; Mitoguazone; O(6)-Methylguanine-DNA Methyltransferase; Ovary; Transfection

1989
Transfectant CHO cells expressing O6-alkylguanine-DNA-alkyltransferase display increased resistance to DNA damage other than O6-guanine alkylation.
    Carcinogenesis, 1987, Volume: 8, Issue:12

    Topics: Alkylation; Animals; Carmustine; Cell Survival; Cricetinae; Cricetulus; Deoxyribonuclease BamHI; Deoxyribonuclease EcoRI; DNA Damage; DNA Restriction Enzymes; Guanine; Methylnitronitrosoguanidine; Methyltransferases; O(6)-Methylguanine-DNA Methyltransferase; Sulfuric Acid Esters; Thioguanine; Transfection; Ultraviolet Rays

1987
Formation of blocking lesions at identical DNA sequences by the nitrosourea and platinum classes of anticancer drugs.
    Cancer research, 1987, Oct-01, Volume: 47, Issue:19

    Topics: Base Sequence; Carmustine; Cisplatin; DNA; DNA Damage; Guanine; Oncogenes; Simian virus 40; Structure-Activity Relationship

1987
Modulation of nitrosourea resistance in myeloid leukemias.
    Blood, 1988, Volume: 71, Issue:5

    Topics: Carmustine; Cell Differentiation; Colony-Stimulating Factors; DNA Repair; Drug Resistance; Guanine; Hematopoietic Stem Cells; Humans; Leukemia, Myeloid; Leukemia, Myeloid, Acute; Methyltransferases; Neoplasm Proteins; Neoplastic Stem Cells; O(6)-Methylguanine-DNA Methyltransferase; Tumor Cells, Cultured

1988
Preferential alkylation by 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU) of guanines with guanines as neighboring bases in DNA.
    Biochemical pharmacology, 1988, Mar-15, Volume: 37, Issue:6

    Topics: Alkylation; Base Sequence; Carmustine; DNA; Guanine; Nucleic Acid Conformation; Polydeoxyribonucleotides; Sonication

1988
Increased repair of O6-alkylguanine DNA adducts in glioma-derived human cells resistant to the cytotoxic and cytogenetic effects of 1,3-bis(2-chloroethyl)-1-nitrosourea.
    Carcinogenesis, 1986, Volume: 7, Issue:6

    Topics: Alkylation; Carmustine; Cell Line; Cell Survival; DNA; DNA Repair; Dose-Response Relationship, Drug; Drug Resistance; Glioma; Guanine; Humans; Methylnitrosourea; Methyltransferases; Nitroso Compounds; O(6)-Methylguanine-DNA Methyltransferase; Sister Chromatid Exchange; Tritium

1986
Repair of O6-(2-chloroethyl)guanine mediates the biological effects of chloroethylnitrosoureas.
    Environmental health perspectives, 1985, Volume: 62

    Topics: Alkylation; Animals; Carmustine; Cell Line; Cell Survival; DNA; DNA Repair; Drug Resistance; Ethylnitrosourea; Guanine; Kinetics; L Cells; Methyltransferases; Mice; O(6)-Methylguanine-DNA Methyltransferase; Sister Chromatid Exchange

1985
DNA repair with purines and pyrimidines in radiation- and carcinogen-damaged normal and xeroderma pigmentosum human cells.
    Cancer research, 1973, Volume: 33, Issue:2

    Topics: Adenine; Carcinogens; Carmustine; Cells, Cultured; Deoxyadenosines; DNA; DNA Repair; DNA, Neoplasm; Guanidines; Guanine; HeLa Cells; Humans; Hydroxyurea; Hypoxanthines; Nitroso Compounds; Quinolines; Radiation Effects; Skin; Ultraviolet Rays; Xeroderma Pigmentosum

1973
Molecular pharmacology of the haloethyl nitrosoureas: formation of 6-hydroxyethylguanine in DNA treated with BCNU (N,N1-bis[2-chloroethyl]-N-nitrosourea).
    Biochemical and biophysical research communications, 1981, May-15, Volume: 100, Issue:1

    Topics: Carmustine; Chemical Phenomena; Chemistry; Chromatography, High Pressure Liquid; DNA; Guanine; Indicators and Reagents; Methods; Spectrophotometry, Ultraviolet

1981
Formation of the cross-linked base, diguanylethane, in DNA treated with N,N'-bis(2-chloroethyl)-N-nitrosourea.
    Cancer research, 1981, Volume: 41, Issue:2

    Topics: Carmustine; Chemical Phenomena; Chemistry; Chromatography, High Pressure Liquid; Cross-Linking Reagents; DNA; Guanine

1981
Increased killing of prostate, breast, colon, and lung tumor cells by the combination of inactivators of O6-alkylguanine-DNA alkyltransferase and N,N'-bis(2-chloroethyl)-N-nitrosourea.
    Biochemical pharmacology, 1995, Oct-12, Volume: 50, Issue:8

    Topics: Antineoplastic Agents, Alkylating; Carmustine; Cell Death; Drug Resistance; Drug Therapy, Combination; Enzyme Inhibitors; Guanine; Humans; Methyltransferases; O(6)-Methylguanine-DNA Methyltransferase; Tumor Cells, Cultured

1995
Sensitization of human colon tumour cell lines to carmustine by depletion of O6-alkylguanine-DNA alkyltransferase.
    Journal of cancer research and clinical oncology, 1995, Volume: 121, Issue:4

    Topics: Carmustine; Colonic Neoplasms; Drug Resistance; Drug Screening Assays, Antitumor; Guanine; Humans; Methyltransferases; O(6)-Methylguanine-DNA Methyltransferase; Streptozocin; Time Factors; Tumor Cells, Cultured

1995
Activity of temozolomide in the treatment of central nervous system tumor xenografts.
    Cancer research, 1995, Jul-01, Volume: 55, Issue:13

    Topics: Animals; Carmustine; Central Nervous System Neoplasms; Dacarbazine; Female; Guanine; Humans; Male; Methyltransferases; Mice; Mice, Inbred BALB C; Mice, Nude; Neoplasm Transplantation; O(6)-Methylguanine-DNA Methyltransferase; Procarbazine; Temozolomide; Transplantation, Heterologous

1995
Anti-neoplastic activity of sequenced administration of O6-benzylguanine, streptozotocin, and 1,3-bis(2-chloroethyl)-1-nitrosourea in vitro and in vivo.
    Biochemical pharmacology, 1994, Nov-29, Volume: 48, Issue:11

    Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Carmustine; Glioblastoma; Guanine; Humans; Methyltransferases; Mice; Mice, Nude; O(6)-Methylguanine-DNA Methyltransferase; Streptozocin; Transplantation, Heterologous; Tumor Cells, Cultured; Tumor Stem Cell Assay

1994
Inhibition of O6-alkylguanine-DNA alkyltransferase in animal and human ovarian tumor cell lines by O6-benzylguanine and sensitization to BCNU.
    Cancer chemotherapy and pharmacology, 1995, Volume: 35, Issue:3

    Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Carmustine; Cisplatin; Cystadenocarcinoma, Serous; Drug Resistance; Female; Guanine; Humans; Methyltransferases; Middle Aged; O(6)-Methylguanine-DNA Methyltransferase; Ovarian Neoplasms; Rats; Tumor Cells, Cultured

1995
Biodistribution of O6-benzylguanine and its effectiveness against human brain tumor xenografts when given in polyethylene glycol or cremophor-EL.
    Cancer chemotherapy and pharmacology, 1994, Volume: 35, Issue:2

    Topics: Adjuvants, Pharmaceutic; Animals; Antineoplastic Agents; Carmustine; Child; Chromatography, High Pressure Liquid; Female; Glioblastoma; Glycerol; Guanine; Humans; Injections, Intraperitoneal; Male; Mice; Mice, Inbred BALB C; Mice, Nude; Neoplasm Transplantation; Polyethylene Glycols; Solubility; Tissue Distribution

1994
Extended depletion of O6-methylguanine-DNA methyltransferase activity following O6-benzyl-2'-deoxyguanosine or O6-benzylguanine combined with streptozotocin treatment enhances 1,3-bis(2-chloroethyl)-1-nitrosourea cytotoxicity.
    Cancer research, 1994, Aug-15, Volume: 54, Issue:16

    Topics: Antineoplastic Agents; Carmustine; Deoxyguanosine; Drug Resistance; Drug Screening Assays, Antitumor; Drug Synergism; Guanine; Humans; Methyltransferases; O(6)-Methylguanine-DNA Methyltransferase; Streptozocin; Tumor Cells, Cultured; Tumor Stem Cell Assay

1994
Capacity of individual chronic lymphatic leukemia lymphocytes and leukemic blast cells for repair of O6-ethylguanine in DNA: relation to chemosensitivity in vitro and treatment outcome.
    Cancer research, 1994, Aug-15, Volume: 54, Issue:16

    Topics: Acute Disease; Carmustine; Cyclophosphamide; Cytarabine; DNA Repair; Doxorubicin; Drug Resistance; Ethylnitrosourea; Glutathione; Guanine; Humans; Leukemia, Lymphocytic, Chronic, B-Cell; Leukemia, Myeloid; Lymphocytes; Treatment Outcome

1994
Combined depletion of O6-alkylguanine-DNA alkyltransferase and glutathione to modulate nitrosourea resistance in breast cancer.
    Biochemical pharmacology, 1994, Aug-03, Volume: 48, Issue:3

    Topics: Breast Neoplasms; Carmustine; Cell Line; Cell Survival; Drug Resistance; Ethylnitrosourea; Glutathione; Glutathione Transferase; Guanine; Humans; Methyltransferases; O(6)-Methylguanine-DNA Methyltransferase

1994
Treatment of subcutaneous and intracranial brain tumor xenografts with O6-benzylguanine and 1,3-bis(2-chloroethyl)-1-nitrosourea.
    Cancer chemotherapy and pharmacology, 1993, Volume: 32, Issue:6

    Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Carmustine; Drug Synergism; Guanine; Humans; Medulloblastoma; Methyltransferases; Mice; Mice, Inbred BALB C; Mice, Nude; Neoplasm Transplantation; O(6)-Methylguanine-DNA Methyltransferase; Time Factors

1993
The effects of O6-benzylguanine and hypoxia on the cytotoxicity of 1,3-bis(2-chloroethyl)-1-nitrosourea in nitrosourea-resistant SF-763 cells.
    Cancer chemotherapy and pharmacology, 1993, Volume: 32, Issue:6

    Topics: Biogenic Polyamines; Brain Neoplasms; Carmustine; Cell Hypoxia; Combined Modality Therapy; Drug Resistance; Guanine; Humans; Ornithine Decarboxylase; Tumor Cells, Cultured

1993
Effect of O6-benzylguanine on the sensitivity of human colon tumor xenografts to 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU).
    Biochemical pharmacology, 1993, Jul-20, Volume: 46, Issue:2

    Topics: Animals; Carmustine; Cell Division; Colonic Neoplasms; Drug Synergism; Female; Guanine; Humans; Methyltransferases; Mice; Mice, Nude; Neoplasm Transplantation; O(6)-Methylguanine-DNA Methyltransferase

1993
Prolonged depletion of O6-methylguanine DNA methyltransferase activity following exposure to O6-benzylguanine with or without streptozotocin enhances 1,3-bis(2-chloroethyl)-1-nitrosourea sensitivity in vitro.
    Cancer research, 1993, Sep-15, Volume: 53, Issue:18

    Topics: Carmustine; Cell Survival; Dose-Response Relationship, Drug; Drug Resistance; Guanine; Humans; Methyltransferases; O(6)-Methylguanine-DNA Methyltransferase; RNA, Messenger; Streptozocin; Tumor Cells, Cultured

1993
Synergistic efficacy of O6-benzylguanine and 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU) in a human colon cancer xenograft completely resistant to BCNU alone.
    Biochemical pharmacology, 1993, Jan-26, Volume: 45, Issue:2

    Topics: Alkyl and Aryl Transferases; Animals; Antineoplastic Combined Chemotherapy Protocols; Body Weight; Carmustine; Colonic Neoplasms; Drug Resistance; Drug Synergism; Guanine; Humans; Mice; Mice, Inbred BALB C; Mice, Nude; Neoplasm Transplantation; Transferases; Tumor Cells, Cultured

1993
Effect of O6-benzylguanine on the response to 1,3-bis(2-chloroethyl)-1-nitrosourea in the Dunning R3327G model of prostatic cancer.
    Cancer chemotherapy and pharmacology, 1993, Volume: 32, Issue:3

    Topics: Animals; Carmustine; Drug Interactions; Guanine; Kidney; Liver; Male; Methyltransferases; O(6)-Methylguanine-DNA Methyltransferase; Prostatic Neoplasms; Rats; Tumor Cells, Cultured

1993
Depletion of O6-methylguanine-DNA methyltransferase and potentiation of 1,3-bis(2-chloroethyl)-1-nitrosourea antitumor activity by O6-benzylguanine in vitro.
    Carcinogenesis, 1993, Volume: 14, Issue:5

    Topics: Antineoplastic Agents; Carmustine; Drug Resistance; Drug Synergism; Guanine; HeLa Cells; Humans; Kinetics; Methyltransferases; O(6)-Methylguanine-DNA Methyltransferase; Time Factors; Tumor Cells, Cultured

1993
Ubiquitination-dependent proteolysis of O6-methylguanine-DNA methyltransferase in human and murine tumor cells following inactivation with O6-benzylguanine or 1,3-bis(2-chloroethyl)-1-nitrosourea.
    Biochemistry, 1996, Jan-30, Volume: 35, Issue:4

    Topics: Adenosine Triphosphate; Animals; Blotting, Western; Carmustine; Chromatography, Affinity; Energy Metabolism; Guanine; Humans; Kinetics; Magnesium; Methyltransferases; O(6)-Methylguanine-DNA Methyltransferase; Precipitin Tests; Rats; Tumor Cells, Cultured; Ubiquitins

1996
Potentiation of temozolomide and BCNU cytotoxicity by O(6)-benzylguanine: a comparative study in vitro.
    British journal of cancer, 1996, Volume: 73, Issue:4

    Topics: Antineoplastic Agents; Antineoplastic Agents, Alkylating; Carmustine; Cell Line; Dacarbazine; Dose-Response Relationship, Drug; Drug Synergism; Guanine; Humans; Methyltransferases; O(6)-Methylguanine-DNA Methyltransferase; Temozolomide; Tumor Cells, Cultured

1996
Point mutations in human O6-alkylguanine-DNA alkyltransferase prevent the sensitization by O6-benzylguanine to killing by N,N'-bis (2-chloroethyl)-N-nitrosourea.
    Cancer research, 1996, Apr-01, Volume: 56, Issue:7

    Topics: Animals; Antineoplastic Agents; Base Sequence; Carmustine; Cell Survival; CHO Cells; Cricetinae; Drug Resistance; Guanine; Humans; Methyltransferases; Molecular Sequence Data; O(6)-Methylguanine-DNA Methyltransferase; Point Mutation; Transfection

1996
Differential sensitivity of human and mouse alkyltransferase to O6-benzylguanine using a transgenic model.
    Cancer research, 1996, Apr-15, Volume: 56, Issue:8

    Topics: Animals; Antineoplastic Agents; Base Sequence; Carmustine; CHO Cells; Cricetinae; DNA Primers; Genetic Vectors; Guanine; Humans; Liver; Methyltransferases; Mice; Mice, Nude; Mice, Transgenic; Molecular Sequence Data; O(6)-Methylguanine-DNA Methyltransferase; Polymerase Chain Reaction; Recombinant Fusion Proteins; Transfection

1996
O6-benzylguanine enhances the sensitivity of a glioma xenograft with low O6-alkylguanine-DNA alkyltransferase activity to temozolomide and BCNU.
    British journal of cancer, 1996, Volume: 73, Issue:9

    Topics: Animals; Antineoplastic Agents; Astrocytoma; Body Weight; Carmustine; Cell Division; Cell Line; Dacarbazine; Glioblastoma; Guanine; Humans; Kinetics; Methyltransferases; Mice; Mice, Nude; O(6)-Methylguanine-DNA Methyltransferase; Temozolomide; Time Factors; Transplantation, Heterologous; Tumor Cells, Cultured

1996
Enhancement of melphalan activity by inhibition of DNA polymerase-alpha and DNA polymerase-beta.
    Cancer chemotherapy and pharmacology, 1996, Volume: 38, Issue:4

    Topics: Animals; Antineoplastic Agents; Antineoplastic Agents, Alkylating; Aphidicolin; Carmustine; DNA Polymerase I; DNA Polymerase II; Drug Synergism; Enzyme Inhibitors; Female; Guanine; Humans; Male; Melphalan; Mice; Mice, Inbred BALB C; Mice, Nude; Neoplasm Transplantation; Rhabdomyosarcoma; Zalcitabine

1996
Human CD34+ hematopoietic progenitors have low, cytokine-unresponsive O6-alkylguanine-DNA alkyltransferase and are sensitive to O6-benzylguanine plus BCNU.
    Blood, 1996, Sep-01, Volume: 88, Issue:5

    Topics: Adult; Antigens, CD34; Antineoplastic Agents; Antineoplastic Agents, Alkylating; Bone Marrow Cells; Carmustine; Cells, Cultured; Colony-Forming Units Assay; Culture Media, Conditioned; DNA Damage; DNA Repair; Drug Resistance; Drug Synergism; Enzyme Inhibitors; Erythropoietin; Granulocyte-Macrophage Colony-Stimulating Factor; Guanine; Hematopoietic Stem Cells; Humans; Interleukin-3; Methyltransferases; O(6)-Methylguanine-DNA Methyltransferase; Recombinant Proteins; Stem Cell Factor

1996
Cytotoxicity of fluoroethylating agents is potentiated by O6-benzylguanine.
    Biological & pharmaceutical bulletin, 1996, Volume: 19, Issue:7

    Topics: Antineoplastic Agents; Antineoplastic Agents, Alkylating; Carmustine; Cell Survival; Drug Synergism; Guanine; HeLa Cells; Humans; Iodoacetamide; Lomustine; Nimustine

1996
3-aminobenzamide and/or O6-benzylguanine evaluated as an adjuvant to temozolomide or BCNU treatment in cell lines of variable mismatch repair status and O6-alkylguanine-DNA alkyltransferase activity.
    British journal of cancer, 1996, Volume: 74, Issue:7

    Topics: Antineoplastic Agents, Alkylating; Benzamides; Carmustine; Dacarbazine; DNA Repair; Drug Screening Assays, Antitumor; Drug Synergism; Enzyme Inhibitors; Guanine; Humans; Neoplasms; Temozolomide; Tumor Cells, Cultured

1996
Retroviral transduction of a mutant methylguanine DNA methyltransferase gene into human CD34 cells confers resistance to O6-benzylguanine plus 1,3-bis(2-chloroethyl)-1-nitrosourea.
    Proceedings of the National Academy of Sciences of the United States of America, 1996, Nov-26, Volume: 93, Issue:24

    Topics: Animals; Antigens, CD34; Antineoplastic Agents; Carmustine; Cell Line; Cell Survival; CHO Cells; Cricetinae; DNA Primers; Dose-Response Relationship, Drug; Drug Resistance; Guanine; Humans; Leukemia, Erythroblastic, Acute; Methyltransferases; Mutagenesis; O(6)-Methylguanine-DNA Methyltransferase; Polymerase Chain Reaction; Recombinant Proteins; Transfection

1996
Mismatch repair mutations override alkyltransferase in conferring resistance to temozolomide but not to 1,3-bis(2-chloroethyl)nitrosourea.
    Cancer research, 1996, Dec-01, Volume: 56, Issue:23

    Topics: Antineoplastic Agents, Alkylating; Carmustine; Colonic Neoplasms; Dacarbazine; DNA Adducts; DNA Damage; DNA Repair; Drug Resistance, Neoplasm; Enzyme Inhibitors; Guanine; Humans; Methylation; Methyltransferases; Microsatellite Repeats; Mutation; O(6)-Methylguanine-DNA Methyltransferase; Phenotype; Temozolomide; Tumor Cells, Cultured; Tumor Stem Cell Assay

1996
Intraarterial O6-benzylguanine enables the specific therapy of nitrosourea-resistant intracranial human glioma xenografts in athymic rats with 1,3-bis(2-chloroethyl)-1-nitrosourea.
    Cancer chemotherapy and pharmacology, 1997, Volume: 39, Issue:4

    Topics: Alkyl and Aryl Transferases; Animals; Antineoplastic Agents, Alkylating; Brain Neoplasms; Carmustine; DNA Repair; Drug Resistance, Neoplasm; Glioblastoma; Guanine; Humans; Injections, Intra-Arterial; Rats; Rats, Nude; Transferases; Transplantation, Heterologous

1997
O6-benzylguanine potentiates the in vivo toxicity and clastogenicity of temozolomide and BCNU in mouse bone marrow.
    Blood, 1997, Mar-01, Volume: 89, Issue:5

    Topics: Animals; Antineoplastic Agents; Bone Marrow; Bone Marrow Cells; Carmustine; Cell Division; Dacarbazine; Drug Synergism; Female; Guanine; Hematopoietic Stem Cells; Male; Mice; Temozolomide

1997
Role of O6-methylguanine-DNA methyltransferase, glutathione transferase M3-3 and glutathione in resistance to carmustine in a human non-small cell lung cancer cell line.
    European journal of cancer (Oxford, England : 1990), 1997, Volume: 33, Issue:3

    Topics: Antineoplastic Agents, Alkylating; Carcinoma, Non-Small-Cell Lung; Carmustine; Dose-Response Relationship, Drug; Drug Resistance, Neoplasm; Glutathione; Glutathione Transferase; Guanine; Humans; Lung Neoplasms; Methyltransferases; O(6)-Methylguanine-DNA Methyltransferase; Tumor Cells, Cultured

1997
O6-methylguanine-DNA methyltransferase (MGMT) transfectants of a 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU)-sensitive colon cancer cell line selectively repopulate heterogenous MGMT+/MGMT- xenografts after BCNU and O6-benzylguanine plus BCNU.
    Cancer research, 1997, Nov-01, Volume: 57, Issue:21

    Topics: Animals; Antineoplastic Agents; Carmustine; Colonic Neoplasms; DNA Repair; Drug Resistance, Neoplasm; Female; Guanine; Humans; Mice; Mice, Nude; Neoplasm Proteins; O(6)-Methylguanine-DNA Methyltransferase; Transfection; Transplantation, Heterologous; Tumor Cells, Cultured

1997
Selection for G156A O6-methylguanine DNA methyltransferase gene-transduced hematopoietic progenitors and protection from lethality in mice treated with O6-benzylguanine and 1,3-bis(2-chloroethyl)-1-nitrosourea.
    Cancer research, 1997, Nov-15, Volume: 57, Issue:22

    Topics: Animals; Antineoplastic Agents; Carmustine; Cell Survival; Drug Resistance, Neoplasm; Genetic Vectors; Guanine; Hematopoietic Stem Cell Transplantation; Hematopoietic Stem Cells; Male; Mice; Mice, Inbred C3H; O(6)-Methylguanine-DNA Methyltransferase; Retroviridae; Transfection

1997
Mammalian 3-methyladenine DNA glycosylase protects against the toxicity and clastogenicity of certain chemotherapeutic DNA cross-linking agents.
    Cancer research, 1998, Sep-01, Volume: 58, Issue:17

    Topics: Animals; Antineoplastic Agents, Alkylating; Apoptosis; Carmustine; Cell Survival; DNA Glycosylases; DNA Repair; G2 Phase; Guanine; Humans; Mice; Mitomycin; Mitosis; Mutagens; N-Glycosyl Hydrolases

1998
DNA repair and cellular resistance to alkylating agents in chronic lymphocytic leukemia.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 1997, Volume: 3, Issue:11

    Topics: Antineoplastic Agents, Alkylating; Antineoplastic Combined Chemotherapy Protocols; Carmustine; Cell Nucleus; Chlorambucil; Cyclophosphamide; DNA Damage; DNA Repair; DNA, Neoplasm; Drug Resistance, Neoplasm; Ethylnitrosourea; Guanine; Humans; Leukemia, Lymphocytic, Chronic, B-Cell; Lymphocytes; Prednisone; Vincristine

1997
Retroviral transfer of a bacterial alkyltransferase gene (ada) into human bone marrow cells protects against O6-benzylguanine plus 1, 3-bis(2-chloroethyl)-1-nitrosourea cytotoxicity.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 1997, Volume: 3, Issue:2

    Topics: 3T3 Cells; Adolescent; Adult; Alkyl and Aryl Transferases; Animals; Antineoplastic Combined Chemotherapy Protocols; Bone Marrow Cells; Carmustine; Cell Survival; Female; Genetic Vectors; Guanine; Humans; Infant, Newborn; Male; Mice; Protective Agents; Retroviridae; Stem Cells; Transduction, Genetic

1997
Retroviral transfer of a bacterial alkyltransferase gene into murine bone marrow protects against chloroethylnitrosourea cytotoxicity.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 1995, Volume: 1, Issue:11

    Topics: Animals; Antineoplastic Agents, Alkylating; Bacterial Proteins; Bone Marrow; Carmustine; Enzyme Inhibitors; Escherichia coli Proteins; Ethylnitrosourea; Feasibility Studies; Gene Transfer Techniques; Guanine; Mice; Mice, Inbred CBA; O(6)-Methylguanine-DNA Methyltransferase; Retroviridae; Transcription Factors

1995
Simultaneous protection of G156A methylguanine DNA methyltransferase gene-transduced hematopoietic progenitors and sensitization of tumor cells using O6-benzylguanine and temozolomide.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 1999, Volume: 5, Issue:1

    Topics: Animals; Antineoplastic Agents; Antineoplastic Agents, Alkylating; Carmustine; Colonic Neoplasms; Dacarbazine; Drug Combinations; Drug Resistance, Neoplasm; Guanine; Hematopoietic Stem Cells; Humans; Male; Mice; Mice, Inbred C3H; O(6)-Methylguanine-DNA Methyltransferase; Temozolomide; Transduction, Genetic; Transfection; Tumor Cells, Cultured

1999
Influence of O6-benzylguanine on the anti-tumour activity and normal tissue toxicity of 1,3-bis(2-chloroethyl)-1-nitrosourea and molecular combinations of 5-fluorouracil and 2-chloroethyl-1-nitrosourea in mice.
    British journal of cancer, 1999, Volume: 79, Issue:9-10

    Topics: Animals; Antineoplastic Agents, Alkylating; Carmustine; Colony-Forming Units Assay; Drug Combinations; Drug Resistance, Neoplasm; Enzyme Inhibitors; Ethylnitrosourea; Fluorouracil; Guanine; Humans; Male; Mice; Mice, Nude; O(6)-Methylguanine-DNA Methyltransferase; Tumor Stem Cell Assay

1999
DeltaMGMT-transduced bone marrow infusion increases tolerance to O6-benzylguanine and 1,3-bis(2-chloroethyl)-1-nitrosourea and allows intensive therapy of 1,3-bis(2-chloroethyl)-1-nitrosourea-resistant human colon cancer xenografts.
    Human gene therapy, 1999, Apr-10, Volume: 10, Issue:6

    Topics: Animals; Antineoplastic Agents, Alkylating; Bone Marrow Transplantation; Carmustine; Cell Division; Colonic Neoplasms; Combined Modality Therapy; Drug Resistance, Neoplasm; Genetic Vectors; Guanine; Humans; Mice; Mice, Nude; Neoplasm Transplantation; O(6)-Methylguanine-DNA Methyltransferase; Retroviridae; Transduction, Genetic

1999
Protection of CHO cells by mutant forms of O6-alkylguanine-DNA alkyltransferase from killing by 1,3-bis-(2-chloroethyl)-1-nitrosourea (BCNU) plus O6-benzylguanine or O6-benzyl-8-oxoguanine.
    Biochemical pharmacology, 1999, Jul-15, Volume: 58, Issue:2

    Topics: Animals; Antineoplastic Agents, Alkylating; Carmustine; Cell Survival; CHO Cells; Cricetinae; Drug Interactions; Drug Resistance, Neoplasm; Enzyme Inhibitors; Guanine; Humans; Mutation; O(6)-Methylguanine-DNA Methyltransferase

1999
Acquired resistance to O6-benzylguanine plus chloroethylnitrosoureas in human breast cancer.
    Cancer chemotherapy and pharmacology, 1999, Volume: 44, Issue:4

    Topics: Antineoplastic Agents, Alkylating; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Carmustine; Drug Resistance, Neoplasm; Drug Synergism; Ethylnitrosourea; Glutathione; Guanine; Humans; O(6)-Methylguanine-DNA Methyltransferase; Tumor Cells, Cultured

1999
Role of DNA mismatch repair and p53 in signaling induction of apoptosis by alkylating agents.
    Proceedings of the National Academy of Sciences of the United States of America, 1999, Sep-14, Volume: 96, Issue:19

    Topics: Adenosine Triphosphatases; Alkylating Agents; Animals; Apoptosis; Bacterial Proteins; Carcinogens; Carmustine; Cell Line; Cell Survival; CHO Cells; Cricetinae; DNA Repair; DNA-Binding Proteins; Dose-Response Relationship, Drug; Dose-Response Relationship, Radiation; Escherichia coli Proteins; Guanine; Humans; Methylnitronitrosoguanidine; Mutagens; MutS DNA Mismatch-Binding Protein; Radiation, Ionizing; Signal Transduction; Time Factors; Tumor Suppressor Protein p53

1999
Protection of committed murine haemopoietic progenitors against BCNU toxicity does not predict protection of primitive, multipotent spleen colony-forming cells - implications for chemoprotective gene therapy.
    Leukemia, 1999, Volume: 13, Issue:11

    Topics: Animals; Antineoplastic Agents; Carmustine; Cells, Cultured; Colony-Forming Units Assay; Drug Resistance, Neoplasm; Erythrocytes; Genetic Therapy; Granulocytes; Guanine; Hematopoietic Stem Cells; Humans; Immunohistochemistry; Macrophages; Male; Mice; Micronucleus Tests; Mutagens; Mutation; Nucleotidyltransferases; Spleen; Transduction, Genetic

1999
Prolonged inhibition of O(6)-methylguanine DNA methyltransferase in human tumor cells by O(6)-benzylguanine in vitro and in vivo.
    The Journal of pharmacology and experimental therapeutics, 1999, Volume: 291, Issue:3

    Topics: Animals; Antineoplastic Agents, Alkylating; Brain Neoplasms; Carmustine; Enzyme Inhibitors; Female; Glioma; Guanine; Humans; Male; Mice; Mice, Inbred NOD; Mice, SCID; Neoplasm Transplantation; O(6)-Methylguanine-DNA Methyltransferase; Tumor Cells, Cultured

1999
Characterization of the P140K, PVP(138-140)MLK, and G156A O6-methylguanine-DNA methyltransferase mutants: implications for drug resistance gene therapy.
    Human gene therapy, 1999, Nov-20, Volume: 10, Issue:17

    Topics: Antineoplastic Agents; Carmustine; Cell Survival; Cloning, Molecular; Drug Interactions; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Enzyme Stability; Gene Expression; Genetic Therapy; Guanine; Humans; K562 Cells; Mutation; O(6)-Methylguanine-DNA Methyltransferase; Transfection

1999
Potentiation of BCNU antitumor efficacy by 9-substituted O6-benzylguanines. Effect of metabolism.
    Cancer chemotherapy and pharmacology, 2000, Volume: 45, Issue:1

    Topics: Animals; Antineoplastic Agents; Brain; Carmustine; Drug Synergism; Guanine; Humans; Mice; Mice, Inbred BALB C; Mice, Nude; O(6)-Methylguanine-DNA Methyltransferase; Rats; Rats, Sprague-Dawley

2000
Conserved residue lysine165 is essential for the ability of O6-alkylguanine-DNA alkyltransferase to react with O6-benzylguanine.
    The Biochemical journal, 2000, Apr-15, Volume: 347, Issue:Pt 2

    Topics: Amino Acid Sequence; Amino Acid Substitution; Animals; Antineoplastic Agents; Binding Sites; Carmustine; CHO Cells; Conserved Sequence; Cricetinae; DNA; DNA Repair; Drug Resistance; Escherichia coli; Guanine; Humans; Lysine; Methylnitronitrosoguanidine; Molecular Sequence Data; Mutation; O(6)-Methylguanine-DNA Methyltransferase; Protein Binding; Sequence Alignment; Transfection

2000
Limiting numbers of G156A O(6)-methylguanine-DNA methyltransferase-transduced marrow progenitors repopulate nonmyeloablated mice after drug selection.
    Blood, 2000, May-15, Volume: 95, Issue:10

    Topics: Animals; Antineoplastic Agents; Blood Cell Count; Carmustine; Cell Differentiation; Cell Division; Gene Transfer Techniques; Guanine; Hematopoietic Stem Cell Transplantation; Hematopoietic Stem Cells; Mice; O(6)-Methylguanine-DNA Methyltransferase

2000
O6-benzylguanine-mediated enhancement of nitrosourea activity in Mer- central nervous system tumor xenografts--implications for clinical trials.
    Cancer chemotherapy and pharmacology, 2000, Volume: 45, Issue:6

    Topics: Animals; Antineoplastic Agents; Carmustine; Central Nervous System Neoplasms; Clinical Trials as Topic; Enzyme Inhibitors; Female; Guanine; Humans; Male; Mice; Mice, Inbred BALB C; Mice, Nude; Neoplasm Transplantation; O(6)-Methylguanine-DNA Methyltransferase; Transplantation, Heterologous

2000
Role of O6-alkylguanine-DNA alkyltransferase in the resistance of mouse spermatogenic cells to O6-alkylating agents.
    Journal of reproduction and fertility, 2000, Volume: 119, Issue:2

    Topics: Analysis of Variance; Animals; Antineoplastic Agents, Alkylating; Apoptosis; Carmustine; DNA Repair; Drug Resistance; Enzyme Inhibitors; Guanine; Half-Life; In Situ Nick-End Labeling; Male; Mice; Mice, Inbred BALB C; O(6)-Methylguanine-DNA Methyltransferase; Seminiferous Epithelium; Spermatogonia; Testis; Time Factors

2000
Potentiation of BCNU anticancer activity by O6-benzylguanine: a study in vitro and in vivo.
    Journal of environmental pathology, toxicology and oncology : official organ of the International Society for Environmental Toxicology and Cancer, 2000, Volume: 19, Issue:1-2

    Topics: Alkyl and Aryl Transferases; Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Carmustine; Cell Survival; Drug Synergism; Guanine; Humans; Injections, Subcutaneous; Mice; Mice, Inbred BALB C; Mice, Nude; Neoplasm Transplantation; Stomach Neoplasms; Transplantation, Heterologous; Tumor Cells, Cultured

2000
Protection of hematopoietic cells against combined O6-benzylguanine and chloroethylnitrosourea treatment by mutant forms of O6-methylguanine DNA methyltransferase.
    Bone marrow transplantation, 2000, Volume: 25 Suppl 2

    Topics: Animals; Antineoplastic Agents; Carmustine; DNA Repair; Drug Resistance; Gene Expression; Genetic Therapy; Guanine; Hematopoietic Stem Cell Transplantation; Hematopoietic Stem Cells; Leukemia L1210; Mice; Mutation; O(6)-Methylguanine-DNA Methyltransferase; Retroviridae; Transduction, Genetic

2000
Can O6-alkylguanine-DNA alkyltransferase depletion enhance alkylator activity in the clinic?
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2000, Volume: 6, Issue:8

    Topics: Antineoplastic Agents, Alkylating; Antineoplastic Combined Chemotherapy Protocols; Carmustine; Drug Synergism; Enzyme Activation; Enzyme Inhibitors; Guanine; Humans; O(6)-Methylguanine-DNA Methyltransferase

2000
Direct reversal of DNA damage by mutant methyltransferase protein protects mice against dose-intensified chemotherapy and leads to in vivo selection of hematopoietic stem cells.
    Cancer research, 2000, Sep-15, Volume: 60, Issue:18

    Topics: 3T3 Cells; Animals; Antineoplastic Combined Chemotherapy Protocols; Bone Marrow Transplantation; Carmustine; DNA Damage; DNA Repair; Dose-Response Relationship, Drug; Gene Transfer Techniques; Genetic Vectors; Guanine; Hematopoietic Stem Cells; Humans; Mice; Mice, Inbred C57BL; O(6)-Methylguanine-DNA Methyltransferase; Point Mutation; Rats; Retroviridae; Transduction, Genetic

2000
Effect of O6-benzylguanine on alkylating agent-induced toxicity and mutagenicity. In Chinese hamster ovary cells expressing wild-type and mutant O6-alkylguanine-DNA alkyltransferases.
    Cancer research, 2000, Oct-01, Volume: 60, Issue:19

    Topics: Animals; Antineoplastic Agents, Alkylating; Carmustine; CHO Cells; Cricetinae; Cyclophosphamide; Dacarbazine; Drug Interactions; Enzyme Inhibitors; Guanine; Mutagenicity Tests; Mutagens; O(6)-Methylguanine-DNA Methyltransferase; Temozolomide

2000
O6-benzylguanine potentiates the antitumor effect of locally delivered carmustine against an intracranial rat glioma.
    Cancer research, 2000, Nov-15, Volume: 60, Issue:22

    Topics: Animals; Antineoplastic Agents, Alkylating; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Carmustine; Drug Implants; Drug Synergism; Enzyme Inhibitors; Glioma; Gliosarcoma; Guanine; Humans; Male; Medulloblastoma; O(6)-Methylguanine-DNA Methyltransferase; Rats; Rats, Inbred F344; Stereotaxic Techniques; Tumor Cells, Cultured; Xenograft Model Antitumor Assays

2000
Inactivation of human O(6)-alkylguanine-DNA alkyltransferase by modified oligodeoxyribonucleotides containing O(6)-benzylguanine.
    The Journal of pharmacology and experimental therapeutics, 2001, Volume: 296, Issue:3

    Topics: Antineoplastic Agents, Alkylating; Carmustine; Cell Survival; Drug Resistance; Enzyme Inhibitors; Enzyme Repression; Guanine; HT29 Cells; Humans; O(6)-Methylguanine-DNA Methyltransferase; Oligodeoxyribonucleotides; Organophosphorus Compounds

2001
Thresholds of O6-alkylguanine-DNA alkyltransferase which confer significant resistance of human glial tumor xenografts to treatment with 1,3-bis(2-chloroethyl)-1-nitrosourea or temozolomide.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2001, Volume: 7, Issue:2

    Topics: Animals; Antineoplastic Agents, Alkylating; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Carmustine; Dacarbazine; Deoxyguanosine; Drug Resistance, Neoplasm; Enzyme Inhibitors; Glioma; Guanine; Humans; Mice; Mice, Nude; O(6)-Methylguanine-DNA Methyltransferase; Temozolomide; Transplantation, Heterologous; Tumor Cells, Cultured

2001
Applied molecular evolution of O6-benzylguanine-resistant DNA alkyltransferases in human hematopoietic cells.
    Proceedings of the National Academy of Sciences of the United States of America, 2001, Apr-24, Volume: 98, Issue:9

    Topics: Amino Acid Sequence; Antineoplastic Agents; Carmustine; Cell Death; Cell Survival; Directed Molecular Evolution; Drug Resistance, Neoplasm; Enzyme Stability; Gene Library; Genetic Therapy; Guanine; Humans; K562 Cells; Molecular Sequence Data; Mutation; O(6)-Methylguanine-DNA Methyltransferase; Transduction, Genetic

2001
O6-Benzylguanine potentiates BCNU but not busulfan toxicity in hematopoietic stem cells.
    Experimental hematology, 2001, Volume: 29, Issue:5

    Topics: Alkylation; Animals; Antineoplastic Agents, Alkylating; Busulfan; Carmustine; Cell Line; CHO Cells; Coculture Techniques; Colony-Forming Units Assay; Cricetinae; Cricetulus; DNA Damage; DNA Repair; Erythroid Precursor Cells; Fibroblasts; Guanine; Hematopoietic Stem Cells; Humans; Male; Mice; Mice, Inbred C57BL; O(6)-Methylguanine-DNA Methyltransferase; Stromal Cells; Transfection

2001
Levels of N7-(2-hydroxyethyl)guanine as a molecular dosimeter of drug delivery to human brain tumors.
    Neuro-oncology, 2001, Volume: 3, Issue:4

    Topics: Antineoplastic Agents, Alkylating; Biomarkers; Brain Chemistry; Brain Neoplasms; Carmustine; Chromatography, High Pressure Liquid; Combined Modality Therapy; DNA Adducts; DNA Damage; DNA, Neoplasm; Glioblastoma; Guanine; Humans; Injections, Intralesional

2001
Sequential tumor biopsies in early phase clinical trials of anticancer agents for pharmacodynamic evaluation.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2001, Volume: 7, Issue:10

    Topics: Animals; Antineoplastic Agents; Biopsy; Carmustine; Cisplatin; Clinical Trials, Phase I as Topic; Clinical Trials, Phase II as Topic; Doxorubicin; Fenretinide; Guanine; Humans; Indoles; Neoplasms; O(6)-Methylguanine-DNA Methyltransferase; Paclitaxel; Pyrroles; Tomography, X-Ray Computed; Treatment Outcome; Xenograft Model Antitumor Assays

2001
G156A MGMT-transduced human mesenchymal stem cells can be selectively enriched by O6-benzylguanine and BCNU.
    Journal of hematotherapy & stem cell research, 2001, Volume: 10, Issue:5

    Topics: Animals; Antineoplastic Agents; Bone Marrow Cells; Brain; Carmustine; Cell Survival; Cell Transplantation; Cells, Cultured; DNA; Dose-Response Relationship, Drug; Drug Resistance, Multiple; Dystrophin; Flow Cytometry; Genetic Vectors; Green Fluorescent Proteins; Guanine; Humans; Infusions, Intravenous; Liver; Luminescent Proteins; Lung; Mesoderm; Mice; Mice, Inbred NOD; Mice, SCID; Mutation, Missense; O(6)-Methylguanine-DNA Methyltransferase; Recombinant Fusion Proteins; Retroviridae; Spleen; Stem Cells; Tissue Distribution; Transfection

2001
Induction of lacI mutations in Big Blue Rat-2 cells treated with 1-(2-hydroxyethyl)-1-nitrosourea: a model system for the analysis of mutagenic potential of the hydroxyethyl adducts produced by 1,3-bis (2-chloroethyl)-1-nitrosourea.
    Mutation research, 2001, Dec-12, Volume: 484, Issue:1-2

    Topics: Animals; Bacterial Proteins; Base Sequence; Carmustine; Cell Line; Deoxyguanosine; DNA Adducts; DNA Mutational Analysis; Escherichia coli Proteins; Ethylnitrosourea; Guanine; Lac Repressors; Mutagenicity Tests; Mutagens; Mutation; Rats; Repressor Proteins

2001
Role of cytochrome P450 isoenzymes in metabolism of O(6)-benzylguanine: implications for dacarbazine activation.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2001, Volume: 7, Issue:12

    Topics: Antineoplastic Agents; Biotransformation; Carmustine; Cytochrome P-450 Enzyme System; Cytosol; Dacarbazine; DNA Repair; Guanine; Humans; Isoenzymes; Kinetics; Liver; Microsomes, Liver; Temozolomide

2001
[Expression and drug resistance of human MGMT gene in hemopoietic cells mediated by bicistronic retroviral vector].
    Zhonghua shi yan he lin chuang bing du xue za zhi = Zhonghua shiyan he linchuang bingduxue zazhi = Chinese journal of experimental and clinical virology, 2001, Volume: 15, Issue:3

    Topics: Alkyl and Aryl Transferases; Antineoplastic Agents, Alkylating; Carmustine; DNA Modification Methylases; Drug Resistance, Neoplasm; Gene Transfer Techniques; Guanine; Hematopoietic Stem Cells; Humans; K562 Cells; Retroviridae

2001
Chemotherapy-induced O(6)-benzylguanine-resistant alkyltransferase mutations in mismatch-deficient colon cancer.
    Cancer research, 2002, Jun-01, Volume: 62, Issue:11

    Topics: Adaptor Proteins, Signal Transducing; Alkyl and Aryl Transferases; Animals; Antineoplastic Agents, Alkylating; Antineoplastic Combined Chemotherapy Protocols; Base Pair Mismatch; Carmustine; Carrier Proteins; CHO Cells; Colonic Neoplasms; Cricetinae; DNA Repair; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Drug Synergism; Genes, p53; Guanine; Humans; Mutagenesis; Mutation; MutL Protein Homolog 1; Neoplasm Proteins; Nuclear Proteins; O(6)-Methylguanine-DNA Methyltransferase; RNA, Messenger; Tumor Cells, Cultured

2002
Toxicity of intracranial and intraperitoneal O6-benzyl guanine in combination with BCNU delivered locally in a mouse model.
    Cancer chemotherapy and pharmacology, 2002, Volume: 50, Issue:5

    Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Bone Marrow Diseases; Carmustine; Dose-Response Relationship, Drug; Drug Implants; Drug Synergism; Guanine; Inflammation; Infusion Pumps, Implantable; Infusions, Parenteral; Mice; Mice, Inbred BALB C; Necrosis; Parietal Lobe; Peritoneal Cavity

2002
O6-benzylguanine-mediated enhancement of chemotherapy.
    Molecular cancer therapeutics, 2002, Volume: 1, Issue:11

    Topics: Animals; Antineoplastic Agents; Antineoplastic Agents, Alkylating; Camptothecin; Carmustine; Central Nervous System Neoplasms; Cyclophosphamide; Dacarbazine; DNA; Enzyme Inhibitors; Female; Guanine; Humans; Irinotecan; Male; Mice; Mice, Inbred BALB C; Mice, Nude; Neoplasm Transplantation; Protein Synthesis Inhibitors; Temozolomide

2002
Formation of DNA adducts and tumor growth delay following intratumoral administration of DTI-015.
    Journal of neuro-oncology, 2003, Volume: 62, Issue:3

    Topics: Animals; Antineoplastic Agents, Alkylating; Carmustine; Chromatography, High Pressure Liquid; DNA Adducts; DNA, Neoplasm; Female; Glioma; Guanine; Injections, Intralesional; Injections, Intravenous; Mice; Mice, Inbred C3H; Skin Neoplasms; Spectrophotometry, Ultraviolet; Survival Rate; Tumor Cells, Cultured

2003
Myeloablation is not required to select and maintain expression of the drug-resistance gene, mutant MGMT, in primary and secondary recipients.
    Molecular therapy : the journal of the American Society of Gene Therapy, 2003, Volume: 8, Issue:1

    Topics: Animals; Antineoplastic Agents, Alkylating; Blotting, Southern; Bone Marrow Cells; Bone Marrow Transplantation; Carmustine; Cell Separation; Dose-Response Relationship, Drug; Drug Resistance; Enzyme Inhibitors; Flow Cytometry; Gene Transfer Techniques; Genetic Therapy; Genetic Vectors; Guanine; Humans; Mice; Mice, Inbred C3H; Models, Genetic; Mutation; Neoplasm Transplantation; O(6)-Methylguanine-DNA Methyltransferase; Polymerase Chain Reaction; Stem Cells; Time Factors

2003
Cytotoxicity, DNA damage, and apoptosis induced by new fotemustine analogs on human melanoma cells in relation to O6-methylguanine DNA-methyltransferase expression.
    The Journal of pharmacology and experimental therapeutics, 2003, Volume: 307, Issue:2

    Topics: Antineoplastic Agents; Apoptosis; Carmustine; DNA Damage; Enzyme Inhibitors; Enzyme-Linked Immunosorbent Assay; Guanine; Humans; Melanoma; Nitrosourea Compounds; O(6)-Methylguanine-DNA Methyltransferase; Organophosphorus Compounds; Tumor Cells, Cultured

2003
Sensitization of pancreatic tumor xenografts to carmustine and temozolomide by inactivation of their O6-Methylguanine-DNA methyltransferase with O6-benzylguanine or O6-benzyl-2'-deoxyguanosine.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2003, Sep-01, Volume: 9, Issue:10 Pt 1

    Topics: Alkylating Agents; Animals; Antineoplastic Agents, Alkylating; Carmustine; Cell Line, Tumor; Dacarbazine; Deoxyguanosine; DNA Repair; Dose-Response Relationship, Drug; Enzyme Inhibitors; Guanine; Humans; Male; Mice; Mice, Nude; Neoplasm Transplantation; Neoplasms, Experimental; O(6)-Methylguanine-DNA Methyltransferase; Pancreatic Neoplasms; Temozolomide; Time Factors

2003
In vivo selection of MGMT(P140K) lentivirus-transduced human NOD/SCID repopulating cells without pretransplant irradiation conditioning.
    The Journal of clinical investigation, 2003, Volume: 112, Issue:10

    Topics: Animals; Antigens, CD34; Antineoplastic Agents; Carmustine; Gene Transfer Techniques; Genetic Vectors; Guanine; Hematopoietic Stem Cell Transplantation; Hematopoietic Stem Cells; Humans; Lentivirus; Mice; Mice, SCID; O(6)-Methylguanine-DNA Methyltransferase; Radiation; Severe Combined Immunodeficiency; Transduction, Genetic; Transgenes; Transplantation Conditioning

2003
Hematopoietic expression of O(6)-methylguanine DNA methyltransferase-P140K allows intensive treatment of human glioma xenografts with combination O(6)-benzylguanine and 1,3-bis-(2-chloroethyl)-1-nitrosourea.
    Molecular cancer therapeutics, 2003, Volume: 2, Issue:12

    Topics: Animals; Antineoplastic Agents, Alkylating; Bone Marrow; Brain Neoplasms; Carmustine; Glioma; Guanine; Humans; Mice; Mice, Inbred NOD; Mice, SCID; O(6)-Methylguanine-DNA Methyltransferase; Transduction, Genetic; Transplantation, Heterologous

2003
In vivo selection for human and murine hematopoietic cells transduced with a therapeutic MGMT lentiviral vector that inhibits HIV replication.
    Molecular therapy : the journal of the American Society of Gene Therapy, 2004, Volume: 9, Issue:2

    Topics: Animals; Carmustine; Flow Cytometry; Gene Products, env; Genetic Vectors; Guanine; Hematopoietic Stem Cells; HIV-1; Humans; Lentivirus; Mice; Mice, Inbred NOD; Mice, SCID; O(6)-Methylguanine-DNA Methyltransferase; T-Lymphocytes; Transduction, Genetic; Virus Replication

2004
Interstitial infusion of carmustine in the rat brain stem with systemic administration of O6-benzylguanine.
    Journal of neuro-oncology, 2004, Volume: 67, Issue:3

    Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Brain Stem; Carmustine; Guanine; Infusion Pumps; Injections, Intraperitoneal; Macrophages; Male; Neutrophils; Rats; Rats, Sprague-Dawley; Stereotaxic Techniques

2004
Hematopoietic stem cell gene therapy of murine protoporphyria by methylguanine-DNA-methyltransferase-mediated in vivo drug selection.
    Gene therapy, 2004, Volume: 11, Issue:22

    Topics: Animals; Antineoplastic Agents; Carmustine; Female; Ferrochelatase; Genetic Engineering; Genetic Therapy; Genetic Vectors; Guanine; Lentivirus; Male; Mice; Mice, Inbred BALB C; Models, Animal; O(6)-Methylguanine-DNA Methyltransferase; Protoporphyria, Erythropoietic; Stem Cell Transplantation; Stem Cells; Transduction, Genetic

2004
Brain tumor cell lines resistant to O6-benzylguanine/1,3-bis(2-chloroethyl)-1-nitrosourea chemotherapy have O6-alkylguanine-DNA alkyltransferase mutations.
    Molecular cancer therapeutics, 2004, Volume: 3, Issue:9

    Topics: Antineoplastic Agents; Brain Neoplasms; Carmustine; Cell Line, Tumor; Deoxyguanosine; Drug Resistance, Neoplasm; Guanine; Humans; Mutation; O(6)-Methylguanine-DNA Methyltransferase; Polymorphism, Genetic

2004
Beta-glucuronidase-cleavable prodrugs of O6-benzylguanine and O6-benzyl-2'-deoxyguanosine.
    Journal of medicinal chemistry, 2005, Jan-13, Volume: 48, Issue:1

    Topics: Alkyl and Aryl Transferases; Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Biochemistry; Carmustine; Cattle; Cell Death; Deoxyguanosine; Drug Stability; Enzyme Activation; Escherichia coli; Glucuronidase; Guanine; HT29 Cells; Humans; Hydrolysis; Kinetics; Liver; Prodrugs

2005
Inactivated MGMT by O6-benzylguanine is associated with prolonged G2/M arrest in cancer cells treated with BCNU.
    Oncogene, 2005, Mar-24, Volume: 24, Issue:13

    Topics: Amino Acid Substitution; Carmustine; Cell Cycle; Cell Death; Cell Division; Cell Line, Tumor; DNA Damage; Drug Resistance, Neoplasm; G2 Phase; Guanine; Humans; Mutagenesis, Site-Directed; O(6)-Methylguanine-DNA Methyltransferase

2005
O6-methylguanine-DNA methyltransferase, O6-benzylguanine, and resistance to clinical alkylators in pediatric primary brain tumor cell lines.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2005, Apr-01, Volume: 11, Issue:7

    Topics: Adolescent; Antineoplastic Agents, Alkylating; Brain; Carmustine; Cell Survival; Child; Child, Preschool; Dacarbazine; Dose-Response Relationship, Drug; Drug Resistance, Neoplasm; Drug Synergism; Enzyme Inhibitors; Female; Guanine; Humans; Male; O(6)-Methylguanine-DNA Methyltransferase; Temozolomide; Time Factors; Tumor Cells, Cultured

2005
Mitochondrial targeting of human O6-methylguanine DNA methyltransferase protects against cell killing by chemotherapeutic alkylating agents.
    Cancer research, 2005, Apr-15, Volume: 65, Issue:8

    Topics: Antigens, CD34; Antineoplastic Agents, Alkylating; Carmustine; Cell Death; Cell Nucleus; Dacarbazine; DNA Damage; DNA Repair; Drug Resistance, Neoplasm; Guanine; Hematopoietic Stem Cells; Humans; K562 Cells; Methyl Methanesulfonate; Mitochondria; O(6)-Methylguanine-DNA Methyltransferase; Temozolomide; Transfection

2005
Role of O6-alkylguanine-DNA alkyltransferase in protecting against 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU)-induced long-term toxicities.
    The Journal of pharmacology and experimental therapeutics, 2005, Volume: 315, Issue:3

    Topics: Animals; Antineoplastic Agents, Alkylating; Body Weight; Carmustine; Crosses, Genetic; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Interactions; Female; Guanine; Kidney; Liver; Lung; Male; Maximum Tolerated Dose; Mice; Mice, Inbred C57BL; Mice, Mutant Strains; O(6)-Methylguanine-DNA Methyltransferase; Organ Size; Random Allocation; Survival Analysis; Time Factors

2005
Differential competitive resistance to methylating versus chloroethylating agents among five O6-alkylguanine DNA alkyltransferases in human hematopoietic cells.
    Molecular cancer therapeutics, 2006, Volume: 5, Issue:1

    Topics: Alkylating Agents; Carmustine; Dacarbazine; Drug Resistance; Genetic Engineering; Guanine; Hematopoietic Stem Cells; Humans; K562 Cells; Mutation; O(6)-Methylguanine-DNA Methyltransferase; Temozolomide; Transduction, Genetic

2006
Levels and distribution of BCNU in GBM tumors following intratumoral injection of DTI-015 (BCNU-ethanol).
    Neuro-oncology, 2007, Volume: 9, Issue:1

    Topics: Antineoplastic Agents, Alkylating; Brain Neoplasms; Carmustine; Chromatography, High Pressure Liquid; Cross-Linking Reagents; DNA, Neoplasm; Ethanol; Glioblastoma; Guanine; Humans; Injections, Intralesional; Tumor Cells, Cultured

2007
Role of O6-methylguanine-DNA methyltransferase in protecting from alkylating agent-induced toxicity and mutations in mice.
    Carcinogenesis, 2007, Volume: 28, Issue:5

    Topics: Alkylating Agents; Animals; Carmustine; Cell Line, Tumor; Cyclophosphamide; Dacarbazine; Guanine; Male; Mice; Mice, Transgenic; Mutagenicity Tests; Mutation; O(6)-Methylguanine-DNA Methyltransferase; Temozolomide; Transfection

2007
The Fanconi anemia (FA) pathway confers glioma resistance to DNA alkylating agents.
    Journal of molecular medicine (Berlin, Germany), 2007, Volume: 85, Issue:5

    Topics: Antineoplastic Agents, Alkylating; Brain Neoplasms; Carmustine; Cell Line, Tumor; Curcumin; Dacarbazine; DNA Modification Methylases; DNA Repair; DNA Repair Enzymes; Dose-Response Relationship, Drug; Drug Resistance, Neoplasm; Enzyme Inhibitors; Fanconi Anemia Complementation Group D2 Protein; Fanconi Anemia Complementation Group F Protein; Fanconi Anemia Complementation Group Proteins; Glioma; Guanine; Humans; Protein Processing, Post-Translational; RNA Interference; RNA, Small Interfering; Temozolomide; Time Factors; Transfection; Tumor Suppressor Proteins; Ubiquitins

2007
Stable differentiation and clonality of murine long-term hematopoiesis after extended reduced-intensity selection for MGMT P140K transgene expression.
    Blood, 2007, Sep-15, Volume: 110, Issue:6

    Topics: Animals; Antineoplastic Agents; Antineoplastic Agents, Alkylating; Bone Marrow Cells; Bone Marrow Transplantation; Carmustine; Cell Differentiation; Genetic Therapy; Guanine; Hematopoiesis; Mice; Mice, Inbred C57BL; Mice, Transgenic; Myeloid Cells; O(6)-Methylguanine-DNA Methyltransferase; Stem Cells; Terminal Repeat Sequences; Transduction, Genetic; Transplantation, Homologous

2007
Inactivation of O(6)-alkylguanine-DNA alkyltransferase by folate esters of O(6)-benzyl-2'-deoxyguanosine and of O(6)-[4-(hydroxymethyl)benzyl]guanine.
    Journal of medicinal chemistry, 2007, Oct-18, Volume: 50, Issue:21

    Topics: Antineoplastic Agents, Alkylating; Carmustine; Carrier Proteins; Cell Line, Tumor; Deoxyguanosine; Drug Resistance, Neoplasm; Esters; Folate Receptors, GPI-Anchored; Folic Acid; Guanine; Humans; Hydrolysis; O(6)-Methylguanine-DNA Methyltransferase; Receptors, Cell Surface; Solubility; Structure-Activity Relationship

2007
Carmustine-resistant cancer cells are sensitized to temozolomide as a result of enhanced mismatch repair during the development of carmustine resistance.
    Molecular pharmacology, 2008, Volume: 74, Issue:1

    Topics: Antineoplastic Agents, Alkylating; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Cadmium Chloride; Carmustine; Cell Line, Tumor; Cell Proliferation; Comet Assay; Dacarbazine; DNA Mismatch Repair; Dose-Response Relationship, Drug; Drug Resistance, Neoplasm; Guanine; Humans; Hydroxylamines; Nimustine; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Temozolomide

2008
Heterogeneity of human glioblastoma: glutathione-S-transferase and methylguanine-methyltransferase.
    Cancer investigation, 2008, Volume: 26, Issue:6

    Topics: Alkylating Agents; Brain Neoplasms; Carmustine; Cell Line, Tumor; Cell Proliferation; DNA Methylation; DNA Modification Methylases; DNA Repair Enzymes; DNA Replication; Dose-Response Relationship, Drug; Enzyme Inhibitors; Ethacrynic Acid; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Glioblastoma; Glutathione S-Transferase pi; Glutathione Transferase; Guanine; Humans; Melphalan; Promoter Regions, Genetic; Tumor Suppressor Proteins

2008
Methylguanine DNA methyltransferase-mediated drug resistance-based selective enrichment and engraftment of transplanted stem cells in skeletal muscle.
    Stem cells (Dayton, Ohio), 2009, Volume: 27, Issue:5

    Topics: Animals; Animals, Genetically Modified; Antigens, CD34; Carmustine; Cell Differentiation; Cell Separation; Cell Survival; Drug Resistance; Guanine; Humans; Mice; Muscle Fibers, Skeletal; Muscle, Skeletal; Myoblasts; O(6)-Methylguanine-DNA Methyltransferase; Regeneration; Retroviridae; Stem Cell Transplantation; Transduction, Genetic

2009
In vivo selection of hematopoietic progenitor cells and temozolomide dose intensification in rhesus macaques through lentiviral transduction with a drug resistance gene.
    The Journal of clinical investigation, 2009, Volume: 119, Issue:7

    Topics: Animals; Antineoplastic Agents, Alkylating; Carmustine; Dacarbazine; Genetic Therapy; Genetic Vectors; Guanine; Hematopoietic Stem Cell Transplantation; Homeodomain Proteins; Lentivirus; Macaca mulatta; O(6)-Methylguanine-DNA Methyltransferase; Temozolomide

2009
Effect of O6-chloroethylguanine DNA lesions on the kinetics and mechanism of micronucleus induction in vivo.
    Environmental and molecular mutagenesis, 2010, Volume: 51, Issue:3

    Topics: Animals; Antineoplastic Agents, Alkylating; Carmustine; DNA Damage; Dose-Response Relationship, Drug; Enzyme Inhibitors; Erythrocytes; Guanine; Kinetics; Male; Mice; Mice, Inbred BALB C; Micronuclei, Chromosome-Defective; O(6)-Methylguanine-DNA Methyltransferase; Toxicity Tests

2010
Efficient and stable MGMT-mediated selection of long-term repopulating stem cells in nonhuman primates.
    The Journal of clinical investigation, 2010, Volume: 120, Issue:7

    Topics: Animals; Carmustine; Genetic Therapy; Guanine; Hematopoietic Stem Cell Transplantation; Macaca nemestrina; Male; O(6)-Methylguanine-DNA Methyltransferase; Papio; Retroviridae; Stem Cells; Transgenes

2010
Quantitative relationship between guanine O(6)-alkyl lesions produced by Onrigin™ and tumor resistance by O(6)-alkylguanine-DNA alkyltransferase.
    Biochemical pharmacology, 2010, Nov-01, Volume: 80, Issue:9

    Topics: Animals; Antineoplastic Agents; Carmustine; Cell Line, Tumor; Dacarbazine; DNA Damage; DNA Methylation; DNA Repair; Drug Resistance, Neoplasm; Guanine; Humans; Hydrazines; Mice; O(6)-Methylguanine-DNA Methyltransferase; Sulfonamides; Temozolomide

2010
Expression of eukaryotic initiation factor 5A and hypusine forming enzymes in glioblastoma patient samples: implications for new targeted therapies.
    PloS one, 2012, Volume: 7, Issue:8

    Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents, Alkylating; Apoptosis; Carmustine; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Cellular Senescence; Dacarbazine; Eukaryotic Translation Initiation Factor 5A; Female; Gene Expression Regulation, Neoplastic; Gene Knockdown Techniques; Glioblastoma; Guanine; Humans; Lysine; Male; Mixed Function Oxygenases; Molecular Targeted Therapy; Neoplasm Grading; Oxidoreductases Acting on CH-NH Group Donors; Peptide Initiation Factors; RNA-Binding Proteins; Temozolomide

2012
Cationic core-shell nanoparticles with carmustine contained within O⁶-benzylguanine shell for glioma therapy.
    Biomaterials, 2013, Volume: 34, Issue:35

    Topics: Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Carmustine; Cations; Cell Line, Tumor; Chemical Phenomena; Disease Models, Animal; Drug Delivery Systems; Female; Glioblastoma; Guanine; Magnetic Resonance Imaging; Male; Nanoparticles; Rats; Rats, Inbred F344

2013
iRGD-mediated core-shell nanoparticles loading carmustine and O
    Journal of drug targeting, 2017, Volume: 25, Issue:3

    Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Carmustine; Cell Line, Tumor; Disease Models, Animal; Drug Carriers; Glioma; Guanine; Humans; Male; Mice; Mice, Inbred BALB C; Mice, Inbred ICR; Mice, Nude; Nanoparticles; Oligopeptides; Tumor Microenvironment

2017