Compounds > carmustine

carmustine and deoxyguanosine

carmustine has been researched along with deoxyguanosine in 13 studies

Research

Studies (13)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's5 (38.46)18.2507
2000's7 (53.85)29.6817
2010's1 (7.69)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Dolan, ME; Erickson, LC; Marathi, UK1
Kokkinakis, DM; Moschel, RC; Pegg, AE; Rudy, JL; Schold, SC1
Duncan, JA; Fischhaber, PL; Gall, AS; Hopkins, PB1
Kokkinakis, DM; Moschel, RC; Pegg, AE; Schold, SC1
Chenna, A; Maruenda, H; Singer, B1
Bocangel, DB; Kokkinakis, DM; Moschel, RC; Pegg, AE; Schold, SC1
Chen, ZP; Huang, Q; Pan, J; Sun, ZF; Wang, AD; Zhou, LY1
Bodell, WJ; Dhananjaya, N; Giannini, DD; Miller, DL; Sprung, CN; Wang, YP1
Ahmed, MM; Chendil, D; Kokkinakis, DM; Moschel, RC; Pegg, AE1
Bacolod, MD; Bigner, DD; Bullock, NS; Colvin, OM; Dolan, ME; Fang, Q; Friedman, HS; Johnson, SP; Modrich, P; Moschel, RC; Pegg, AE1
Loktionova, NA; Moschel, RC; Pegg, AE; Wei, G1
Fang, Q; Javanmard, S; Loktionova, NA; Moschel, RC; Pauly, GT; Pegg, AE1
Alzeer, J; Angelov, T; Hentschel, S; Luedtke, NW; Schärer, OD1

Other Studies

13 other study(ies) available for carmustine and deoxyguanosine

ArticleYear
Extended depletion of O6-methylguanine-DNA methyltransferase activity following O6-benzyl-2'-deoxyguanosine or O6-benzylguanine combined with streptozotocin treatment enhances 1,3-bis(2-chloroethyl)-1-nitrosourea cytotoxicity.
    Cancer research, 1994, Aug-15, Volume: 54, Issue:16

    Topics: Antineoplastic Agents; Carmustine; Deoxyguanosine; Drug Resistance; Drug Screening Assays, Antitumor; Drug Synergism; Guanine; Humans; Methyltransferases; O(6)-Methylguanine-DNA Methyltransferase; Streptozocin; Tumor Cells, Cultured; Tumor Stem Cell Assay

1994
Treatment of human brain tumor xenografts with O6-benzyl-2'-deoxyguanosine and BCNU.
    Cancer research, 1996, May-01, Volume: 56, Issue:9

    Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Carmustine; Cell Death; Deoxyguanosine; Humans; Methyltransferases; Mice; Mice, Inbred BALB C; Mice, Nude; Neoplasm Transplantation; O(6)-Methylguanine-DNA Methyltransferase; Transplantation, Heterologous

1996
Direct demonstration in synthetic oligonucleotides that N,N'-bis(2-chloroethyl)-nitrosourea cross links N1 of deoxyguanosine to N3 of deoxycytidine on opposite strands of duplex DNA.
    Cancer research, 1999, Sep-01, Volume: 59, Issue:17

    Topics: Animals; Antineoplastic Agents, Alkylating; Carmustine; Deoxycytidine; Deoxyguanosine; DNA; Mice; Oligonucleotides

1999
Eradication of human medulloblastoma tumor xenografts with a combination of O6-benzyl-2'-deoxyguanosine and 1,3-bis(2-chloroethyl)1-nitrosourea.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 1999, Volume: 5, Issue:11

    Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Carmustine; Cerebellar Neoplasms; Deoxyguanosine; Humans; Inflammation; Intestinal Mucosa; Medulloblastoma; Mice; Mice, Nude; Mitosis; O(6)-Methylguanine-DNA Methyltransferase; Transplantation, Heterologous; Tumor Cells, Cultured; Weight Loss

1999
Synthesis of para-benzoquinone and 1,3-bis(2-chloroethyl)nitrosourea adducts and their incorporation into oligonucleotides.
    IARC scientific publications, 1999, Issue:150

    Topics: Base Sequence; Benzoquinones; Carmustine; Chromatography, High Pressure Liquid; Deoxyadenosines; Deoxycytidine; Deoxyguanosine; DNA Adducts; Models, Chemical; Molecular Sequence Data; Oligonucleotides

1999
Thresholds of O6-alkylguanine-DNA alkyltransferase which confer significant resistance of human glial tumor xenografts to treatment with 1,3-bis(2-chloroethyl)-1-nitrosourea or temozolomide.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2001, Volume: 7, Issue:2

    Topics: Animals; Antineoplastic Agents, Alkylating; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Carmustine; Dacarbazine; Deoxyguanosine; Drug Resistance, Neoplasm; Enzyme Inhibitors; Glioma; Guanine; Humans; Mice; Mice, Nude; O(6)-Methylguanine-DNA Methyltransferase; Temozolomide; Transplantation, Heterologous; Tumor Cells, Cultured

2001
Antitumor efficacy of SarCNU in a human glioma xenograft model expressing both MGMT and extraneuronal monoamine transporter.
    Journal of neuro-oncology, 2001, Volume: 51, Issue:1

    Topics: Animals; Antineoplastic Agents; Antineoplastic Agents, Alkylating; Brain Neoplasms; Carmustine; Carrier Proteins; Cell Line; Deoxyguanosine; Female; Glioma; Humans; Male; Mice; Mice, Nude; Neoplasm Transplantation; O(6)-Methylguanine-DNA Methyltransferase; Organic Cation Transport Proteins; Transplantation, Heterologous

2001
Induction of lacI mutations in Big Blue Rat-2 cells treated with 1-(2-hydroxyethyl)-1-nitrosourea: a model system for the analysis of mutagenic potential of the hydroxyethyl adducts produced by 1,3-bis (2-chloroethyl)-1-nitrosourea.
    Mutation research, 2001, Dec-12, Volume: 484, Issue:1-2

    Topics: Animals; Bacterial Proteins; Base Sequence; Carmustine; Cell Line; Deoxyguanosine; DNA Adducts; DNA Mutational Analysis; Escherichia coli Proteins; Ethylnitrosourea; Guanine; Lac Repressors; Mutagenicity Tests; Mutagens; Mutation; Rats; Repressor Proteins

2001
Sensitization of pancreatic tumor xenografts to carmustine and temozolomide by inactivation of their O6-Methylguanine-DNA methyltransferase with O6-benzylguanine or O6-benzyl-2'-deoxyguanosine.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2003, Sep-01, Volume: 9, Issue:10 Pt 1

    Topics: Alkylating Agents; Animals; Antineoplastic Agents, Alkylating; Carmustine; Cell Line, Tumor; Dacarbazine; Deoxyguanosine; DNA Repair; Dose-Response Relationship, Drug; Enzyme Inhibitors; Guanine; Humans; Male; Mice; Mice, Nude; Neoplasm Transplantation; Neoplasms, Experimental; O(6)-Methylguanine-DNA Methyltransferase; Pancreatic Neoplasms; Temozolomide; Time Factors

2003
Brain tumor cell lines resistant to O6-benzylguanine/1,3-bis(2-chloroethyl)-1-nitrosourea chemotherapy have O6-alkylguanine-DNA alkyltransferase mutations.
    Molecular cancer therapeutics, 2004, Volume: 3, Issue:9

    Topics: Antineoplastic Agents; Brain Neoplasms; Carmustine; Cell Line, Tumor; Deoxyguanosine; Drug Resistance, Neoplasm; Guanine; Humans; Mutation; O(6)-Methylguanine-DNA Methyltransferase; Polymorphism, Genetic

2004
Beta-glucuronidase-cleavable prodrugs of O6-benzylguanine and O6-benzyl-2'-deoxyguanosine.
    Journal of medicinal chemistry, 2005, Jan-13, Volume: 48, Issue:1

    Topics: Alkyl and Aryl Transferases; Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Biochemistry; Carmustine; Cattle; Cell Death; Deoxyguanosine; Drug Stability; Enzyme Activation; Escherichia coli; Glucuronidase; Guanine; HT29 Cells; Humans; Hydrolysis; Kinetics; Liver; Prodrugs

2005
Inactivation of O(6)-alkylguanine-DNA alkyltransferase by folate esters of O(6)-benzyl-2'-deoxyguanosine and of O(6)-[4-(hydroxymethyl)benzyl]guanine.
    Journal of medicinal chemistry, 2007, Oct-18, Volume: 50, Issue:21

    Topics: Antineoplastic Agents, Alkylating; Carmustine; Carrier Proteins; Cell Line, Tumor; Deoxyguanosine; Drug Resistance, Neoplasm; Esters; Folate Receptors, GPI-Anchored; Folic Acid; Guanine; Humans; Hydrolysis; O(6)-Methylguanine-DNA Methyltransferase; Receptors, Cell Surface; Solubility; Structure-Activity Relationship

2007
Synthesis of DNA interstrand cross-links using a photocaged nucleobase.
    Angewandte Chemie (International ed. in English), 2012, Apr-02, Volume: 51, Issue:14

    Topics: Alkylation; Carmustine; Cross-Linking Reagents; Deoxycytidine; Deoxyguanosine; DNA

2012