cariprazine has been researched along with fluorophosphate* in 1 studies
1 other study(ies) available for cariprazine and fluorophosphate
| Article | Year |
|---|---|
Synthesis of ortho-haloaminoarenes by aryne insertion of nitrogen-halide bonds.
A rapid and general access to ortho-haloaminoarenes has been developed by aryne insertion into N-chloramine, N-bromoamine, and N-iodoamine bonds via two complementary protocols harnessing fluoride-promoted 1,2-elimination of ortho-trimethylsilyl aryltriflates. Typically, electron-deficient N-chloramines effectively react with aryne intermediates generated at elevated temperature with CsF, while less stable N-haloamines are found more efficient under milder, TBAF-mediated aryne formation at room temperature. Both protocols demonstrate a good level of regioselectivity and functional group tolerance. Efforts to elucidate the mechanism of N-X insertion are also discussed. The practical value of this transformation is highlighted by rapid synthesis of novel analogues of the antipsychotic cariprazine. Topics: Amines; Catalysis; Fluorides; Hydrocarbons, Halogenated; Molecular Structure; Nitrogen; Phosphates; Piperazines; Stereoisomerism | 2015 |