cariporide has been researched along with eniporide in 15 studies
| Studies (cariporide) | Trials (cariporide) | Recent Studies (post-2010) (cariporide) | Studies (eniporide) | Trials (eniporide) | Recent Studies (post-2010) (eniporide) |
|---|---|---|---|---|---|
| 409 | 10 | 79 | 32 | 3 | 1 |
| Protein | Taxonomy | cariporide (IC50) | eniporide (IC50) |
|---|---|---|---|
| Sodium/hydrogen exchanger 1 | Homo sapiens (human) | 0.1558 | |
| Sodium/hydrogen exchanger 1 | Oryctolagus cuniculus (rabbit) | 0.008 | |
| Sodium/hydrogen exchanger 3 | Oryctolagus cuniculus (rabbit) | 0.008 | |
| Sodium/hydrogen exchanger 2 | Oryctolagus cuniculus (rabbit) | 0.008 | |
| Sodium/hydrogen exchanger 2 | Homo sapiens (human) | 3.8 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (20.00) | 18.2507 |
| 2000's | 11 (73.33) | 29.6817 |
| 2010's | 1 (6.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Baumgarth, M; Beier, N; Gericke, R | 2 |
| Allen, MC; Brown, JA; Buchholz, AR; Cook, ER; Day, WW; Guzman-Perez, A; Hamanaka, ES; Hill, RJ; Kennedy, SP; Knight, DR; Kowalczyk, PJ; Marala, RB; Mularski, CJ; Novomisle, WA; Ruggeri, RB; Tracey, WR; Wester, RT | 1 |
| Ahmad, S; Atwal, KS; Chen, AY; Chen, BC; DiMarco, JD; Dorso, CR; Doweyko, LM; Dugar, S; Gavin, BJ; Gougoutas, JZ; Grazier, N; Kirby, M; Lan, SJ; Ngu, K; Serafino, R; Wu, SC; Yost, KJ | 1 |
| Ahmad, S; Atwal, KS; Chandrasena, G; Chen, BC; Dorso, CR; Doweyko, L; Kirby, M; O'Neil, SV; Zahler, R; Zhao, R | 1 |
| Bentzien, J; Boyer, SJ; Burke, J; De Lombaert, S; Eickmeier, C; Eldrup, AB; Guo, X; Haist, JV; Hickey, ER; Huber, JD; Kaplita, P; Karmazyn, M; Kemper, R; Kennedy, CA; Kirrane, T; Madwed, JB; Mainolfi, E; Nagaraja, N; Soleymanzadeh, F; Swinamer, A | 1 |
| Beier, N; Fischer, H; Raddatz, P; Seelig, A; Seelig, J | 1 |
| ten Hove, M; van Echteld, CJ; van Emous, JG | 2 |
| Gan, XT; Karmazyn, M; Sostaric, JV | 1 |
| Fukumoto, S; Kawamoto, T; Kimura, H; Kusumoto, K; Sawada, H; Shiraishi, M; Watanabe, T | 1 |
| Adgey, AA; Menown, IB | 1 |
| Abe, A; Fukumoto, S; Igata, H; Ikeda, S; Imamiya, E; Kusumoto, K; Shiraishi, M; Tsuboi, A; Watanabe, T | 1 |
| Brown, JA; Hamanaka, ES; Hill, RJ; Kennedy, SP; Knight, DR; Kong, JX; Marala, RB; Ruggeri, RB; Sun, D; Tracey, WR; Wester, RT | 1 |
| Balshaw, D; Becker, L; Bolli, R; Gross, G; Lathrop, DA; Mentzer, R | 1 |
2 review(s) available for cariporide and eniporide
| Article | Year |
|---|---|
The myocardial Na+/H+ exchanger: a potential therapeutic target for the prevention of myocardial ischaemic and reperfusion injury and attenuation of postinfarction heart failure.
Topics: Adenosine Triphosphate; Anti-Arrhythmia Agents; Cardiac Output, Low; Clinical Trials as Topic; Guanidines; Humans; Hydrogen-Ion Concentration; Myocardial Infarction; Myocardial Ischemia; Myocardial Reperfusion Injury; Phosphorylation; Sodium-Hydrogen Exchangers; Sulfones | 2001 |
Myocardial protection at a crossroads: the need for translation into clinical therapy.
Topics: Animals; Cardiotonic Agents; Clinical Trials as Topic; Clinical Trials, Phase III as Topic; Coronary Artery Bypass; Drug Evaluation, Preclinical; Drug Utilization; Guanidines; Humans; Myocardial Infarction; Myocardial Ischemia; Myocardial Reperfusion Injury; Prospective Studies; Sodium-Hydrogen Exchangers; Sulfones; Treatment Outcome | 2004 |
13 other study(ies) available for cariporide and eniporide
| Article | Year |
|---|---|
(2-Methyl-5-(methylsulfonyl)benzoyl)guanidine Na+/H+ antiporter inhibitors.
Topics: Animals; Crystallography, X-Ray; Erythrocytes; Guanidines; Models, Chemical; Models, Molecular; Protein Conformation; Rabbits; Sodium; Sodium-Hydrogen Exchangers; Structure-Activity Relationship; Sulfones | 1997 |
Bicyclic acylguanidine Na+/H+ antiporter inhibitors.
Topics: Animals; Blood Platelets; Cell Size; Erythrocytes; Guanidines; Humans; In Vitro Techniques; Rabbits; Sodium; Sodium-Hydrogen Exchangers; Structure-Activity Relationship; Sulfones | 1998 |
Discovery of zoniporide: a potent and selective sodium-hydrogen exchanger type 1 (NHE-1) inhibitor with high aqueous solubility.
Topics: Animals; Dogs; Guanidines; Injections, Intravenous; Molecular Conformation; Protective Agents; Pyrazoles; Rats; Sodium-Hydrogen Exchangers; Solubility; Water | 2001 |
Arylcyclopropanecarboxyl guanidines as novel, potent, and selective inhibitors of the sodium hydrogen exchanger isoform-1.
Topics: Administration, Oral; Animals; Biological Availability; Cation Transport Proteins; Cell Line; Cricetinae; Crystallography, X-Ray; Cyclopropanes; Guanidines; Humans; Membrane Proteins; Protein Isoforms; Rats; Sodium-Hydrogen Exchanger 1; Sodium-Hydrogen Exchangers; Stereoisomerism; Structure-Activity Relationship | 2001 |
Synthesis and biological activity of 5-aryl-4-(4-(5-methyl-1H-imidazol-4-yl)piperidin-1-yl)pyrimidine analogs as potent, highly selective, and orally bioavailable NHE-1 inhibitors.
Topics: Administration, Oral; Animals; Biological Availability; Inhibitory Concentration 50; Molecular Structure; Piperidines; Pyrimidines; Rats; Sodium-Hydrogen Exchangers; Structure-Activity Relationship | 2006 |
Identification of a potent sodium hydrogen exchanger isoform 1 (NHE1) inhibitor with a suitable profile for chronic dosing and demonstrated cardioprotective effects in a preclinical model of myocardial infarction in the rat.
Topics: Animals; Benzamides; Biological Availability; Blood Platelets; Cell Line; Cell Membrane Permeability; Cell Size; Cytochrome P-450 Enzyme Inhibitors; Dogs; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Guanidines; Humans; Male; Membranes, Artificial; Microsomes, Liver; Models, Molecular; Myocardial Infarction; Myocardial Reperfusion Injury; Permeability; Protein Isoforms; Rats; Rats, Sprague-Dawley; Sodium-Hydrogen Exchanger 1; Sodium-Hydrogen Exchangers; Structure-Activity Relationship | 2012 |
New drugs for the Na+/H+ exchanger. Influence of Na+ concentration and determination of inhibition constants with a microphysiometer.
Topics: Animals; Cardiovascular Agents; CHO Cells; Cricetinae; Dose-Response Relationship, Drug; Erythrocytes; Fibroblasts; Guanidines; Hydrogen-Ion Concentration; Mice; Microchemistry; Osmolar Concentration; Protein Isoforms; Protons; Rabbits; Sodium; Sodium-Hydrogen Exchangers; Sulfones | 1999 |
Na+-overload during ischemia and reperfusion in rat hearts: comparison of the Na+/H+-exchange blockers EIPA, HOE642 and EMD96785.
Topics: Amiloride; Animals; Guanidines; In Vitro Techniques; Magnetic Resonance Spectroscopy; Myocardial Ischemia; Myocardial Reperfusion Injury; Rats; Sodium; Sodium-Hydrogen Exchangers; Sulfones | 2000 |
Potent and selective inhibition of the human Na+/H+ exchanger isoform NHE1 by a novel aminoguanidine derivative T-162559.
Topics: Animals; Calcium; Carrier Proteins; CHO Cells; Cricetinae; Dose-Response Relationship, Drug; Gene Expression; Guanidines; Humans; Protein Isoforms; Quinolines; Sodium-Bicarbonate Symporters; Sodium-Calcium Exchanger; Sodium-Hydrogen Exchangers; Sulfones | 2001 |
Cardioprotective therapy and sodium-hydrogen exchange inhibition: current concepts and future goals.
Topics: Angioplasty, Balloon, Coronary; Anti-Arrhythmia Agents; Apoptosis; Guanidines; Humans; Ischemic Preconditioning; Myocardial Infarction; Myocardial Reperfusion; Reperfusion Injury; Sodium-Hydrogen Exchangers; Sulfones; Thrombolytic Therapy | 2001 |
In vitro and in vivo pharmacology of a structurally novel Na+-H+ exchange inhibitor, T-162559.
Topics: Animals; Blood Platelets; Cardiotonic Agents; Dose-Response Relationship, Drug; Guanidines; Humans; In Vitro Techniques; Injections, Intravenous; Male; Myocardial Infarction; Myocardial Ischemia; Myocardial Reperfusion Injury; Quinolines; Rabbits; Rats; Rats, Wistar; Sodium-Hydrogen Exchangers; Sulfones | 2002 |
Zoniporide: a potent and highly selective inhibitor of human Na(+)/H(+) exchanger-1.
Topics: Cells, Cultured; Fibroblasts; Guanidines; Humans; Pyrazoles; Sodium; Sodium-Hydrogen Exchangers; Sulfones | 2002 |
Na+ overload during ischemia and reperfusion in rat hearts: comparison of the Na+/H+ exchange blockers EIPA, cariporide and eniporide.
Topics: Amiloride; Animals; Anti-Arrhythmia Agents; Calcium; Guanidines; Hydrogen-Ion Concentration; Ischemia; Magnetic Resonance Spectroscopy; Male; Myocardial Contraction; Myocardium; Perfusion; Phosphates; Rats; Rats, Wistar; Reperfusion Injury; Sodium; Sodium-Hydrogen Exchangers; Sulfones; Time Factors | 2003 |