Page last updated: 2024-09-04

cariporide and amiloride

cariporide has been researched along with amiloride in 44 studies

Compound Research Comparison

Studies (cariporide)	Trials (cariporide)	Recent Studies (post-2010) (cariporide)	Studies (amiloride)	Trials (amiloride)	Recent Studies (post-2010) (amiloride)
409	10	79	7,584	339	788

Protein Interaction Comparison

Protein	Taxonomy	amiloride (IC50)
Urokinase-type plasminogen activator	Homo sapiens (human)	4.7
Urokinase-type plasminogen activator	Mus musculus (house mouse)	2.3
Amine oxidase [flavin-containing] A	Homo sapiens (human)	3.909
Sodium/hydrogen exchanger 1	Rattus norvegicus (Norway rat)	1
Amiloride-sensitive sodium channel subunit alpha	Homo sapiens (human)	0.776
Sodium/hydrogen exchanger 2	Oryctolagus cuniculus (rabbit)	1
Acid-sensing ion channel 3	Homo sapiens (human)	4.4

Research

Studies (44)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	8 (18.18)	18.2507
2000's	29 (65.91)	29.6817
2010's	7 (15.91)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Cala, PM; King, SA; Nygaard, EB; Pedersen, SF; Rigor, RR	1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A	1
Silakari, O; Singh, D	1
Haist, JV; Hoque, AN; Karmazyn, M	1
Hoque, AN; Karmazyn, M	1
Burckhardt, G; Hropot, M; Jansen, HW; Krick, W; Lang, HJ; Schwark, JR	1
Bookstein, C; Chang, EB; McSwine, RL; Musch, MW; Rao, M; Xie, Y	1
Frishman, WH; Gurell, D; Levitsky, J	1
Karmazyn, M	2
Drumm, K; Freudinger, R; Gassner, B; Gekle, M; Mildenberger, S; Silbernagl, S	1
Elsing, C; Hübner, C; Stremmel, W	1
Hashimoto, K	1
Chattou, S; Coulombe, A; Diacono, J; Feuvray, D; John, G; Le Grand, B	1
Cingolani, HE; Mosca, SM	1
Cermak, R; Lawnitzak, C; Scharrer, E	1
Ladilov, YV; Piper, HM; Schäfer, C; Schäfer, M	1
ten Hove, M; van Echteld, CJ; van Emous, JG	2
Hattori, R; Imamura, H; Matsubara, H; Moriguchi, Y; Nakao, Y; Omiya, H; Osako, M; Otani, H; Yamamura, T	1
Inagaki, R; Muramatsu, I; Suzuki, F; Taniguchi, T	1
Abrahamson, DR; Chambrey, R; Eladari, D; Paillard, M; Podevin, RA; Quentin, F; St John, PL; Warnock, DG	1
Dixon, SJ; Grover, AK; Haist, JV; Holmes, ME; Karmazyn, M; Mwanjewe, J; Samson, SE; Wilson, JX	1
Kleemann, HW; Tannock, IF; Wong, P	1
Caligiuri, A; De Franco, RM; Failli, P; Geerts, A; Gentilini, A; Gentilini, P; Marra, F; Mazzetti, L; Meucci, M; Pinzani, M; Romanelli, RG; Rombouts, K; Vanasia, M	1
Jessel, A; Karmazyn, M; Lasley, RD; Mentzer, RM	1
Duranton, C; Huber, SM; Lang, F; Lang, KS; Myssina, S; Tanneur, V; Wieder, T	1
Schiffrin, EL	1
Bock, J; Gerhardt, E; Lang, F; Müller, MM; Schneider, D; Schulz, JB; Wolburg, H	1
Kennedy, DJ; Raldua, D; Thwaites, DT	1
Hausberg, M; Hillebrand, U; Kliche, K; Ludwig, T; Nikova, D; Oberleithner, H; Riethmüller, C; Schillers, H; Schneider, SW; Shahin, V; Stock, C	1
Dhalla, NS; Saini, HK	1
Bachmann, O; Heinzmann, A; Mack, A; Manns, MP; Seidler, U	1
Goerge, T; Huck, V; Niemeyer, A; Oberleithner, H; Ossig, R; Rogge, P; Schnaeker, EM; Schneider, MF; Schneider, SW	1
Hisamitsu, T; Iwata, Y; Katanosaka, Y; Wakabayashi, S	1
Hopfer, U; Jose, PA; Pinho, MJ; Pinto, V; Soares-da-Silva, P	1
Foskett, JK; Harlow, JM; Lee, RJ; Limberis, MP; Wilson, JM	1
Arreola, J; Kaba, NK; Kim, M; Knauf, PA; Law, FY; Lefort, CT; Martel-Gallegos, G; Schultz, J; Waugh, RE	1
Chua, J; Dean, JB; Hartzler, LK; Havlin, K; Hubbell, BB; Kalra, A; Kersh, AE; Nanagas, V; Putnam, RW; Ritucci, NA; Whitesell, R	1
Carraway, KL; Chen, TY; Dunn, T; Floyd, C; Gorin, FA; Harley, W; Hegde, M; Leon, L; Lyeth, B; Nantz, MH; Palandoken, H; Zhang, XD	1
Martens, H; Noci, B; Rabbani, I; Siegling-Vlitakis, C	1
Matsuzaki, T; Okamoto, H; Sasahara, T; Tsutsui, M; Yayama, K	1
Mihaila, RG	1
Chang, CW; Chang, HR; Hsieh, JC; Jeng, JR; Lien, CF; Lin, JH; Yang, KT	1

Reviews

6 review(s) available for cariporide and amiloride

Article	Year
Sodium ion/hydrogen ion exchange inhibition: a new pharmacologic approach to myocardial ischemia and reperfusion injury. Journal of clinical pharmacology, 1998, Volume: 38, Issue:10 Topics: Amiloride; Animals; Anti-Arrhythmia Agents; Diuretics; Guanidines; Humans; Myocardial Ischemia; Myocardial Reperfusion Injury; Sodium-Hydrogen Exchangers; Sulfones	1998
The role of the myocardial sodium-hydrogen exchanger in mediating ischemic and reperfusion injury. From amiloride to cariporide. Annals of the New York Academy of Sciences, 1999, Jun-30, Volume: 874 Topics: Amiloride; Animals; Guanidines; Humans; Myocardial Ischemia; Myocardial Reperfusion Injury; Myocardium; Sodium-Hydrogen Exchangers; Sulfones; Ventricular Remodeling	1999
Mechanisms of protection of the ischemic and reperfused myocardium by sodium-hydrogen exchange inhibition. Journal of thrombosis and thrombolysis, 1999, Volume: 8, Issue:1 Topics: Amiloride; Animals; Anti-Arrhythmia Agents; Diuretics; Guanidines; Humans; Myocardial Reperfusion Injury; Sodium-Hydrogen Exchangers; Sulfones	1999
[Na+/H+ exchange inhibitors]. Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme, 2000, Volume: 45, Issue:6 Suppl Topics: Amiloride; Animals; Anti-Arrhythmia Agents; Clinical Trials as Topic; Drug Design; Guanidines; Humans; Myocardial Ischemia; Sodium-Hydrogen Exchangers; Sulfones	2000
Intracellular sodium hydrogen exchange inhibition and clinical myocardial protection. The Annals of thoracic surgery, 2003, Volume: 75, Issue:2 Topics: Amiloride; Animals; Coronary Artery Bypass; Creatine Kinase; Diuretics; Guanidines; Humans; Immunohistochemistry; Ischemic Preconditioning, Myocardial; Myocardial Reperfusion Injury; Sodium-Hydrogen Exchangers; Sulfones	2003
A minireview on NHE1 inhibitors. A rediscovered hope in oncohematology. Biomedical papers of the Medical Faculty of the University Palacky, Olomouc, Czechoslovakia, 2015, Volume: 159, Issue:4 Topics: Amiloride; Antineoplastic Agents; Apoptosis; Cation Transport Proteins; Cell Line, Tumor; DNA Damage; Drug Interactions; fms-Like Tyrosine Kinase 3; Genes, abl; Guanidines; Heme Oxygenase-1; Humans; Hydrogen-Ion Concentration; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Imatinib Mesylate; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Leukemia, Myeloid, Acute; Mutation; Niacinamide; Osmolar Concentration; Patents as Topic; Phenylurea Compounds; Protein Kinase Inhibitors; Signal Transduction; Sodium-Hydrogen Exchanger 1; Sodium-Hydrogen Exchangers; Sorafenib; Sulfones; Tumor Hypoxia; Up-Regulation	2015

Other Studies

38 other study(ies) available for cariporide and amiloride

Article	Year
NHE1 inhibition by amiloride- and benzoylguanidine-type compounds. Inhibitor binding loci deduced from chimeras of NHE1 homologues with endogenous differences in inhibitor sensitivity. The Journal of biological chemistry, 2007, Jul-06, Volume: 282, Issue:27 Topics: Amiloride; Animals; Binding Sites; Cation Transport Proteins; Cell Line; Cricetinae; Cricetulus; Flounder; Guanidines; Humans; Mutation; Protein Structure, Tertiary; Recombinant Fusion Proteins; Sodium Channel Blockers; Sodium-Hydrogen Exchanger 1; Sodium-Hydrogen Exchangers; Species Specificity; Sulfones; Urodela	2007
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. Chemical research in toxicology, 2010, Volume: 23, Issue:1 Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship	2010
Sodium hydrogen exchanger inhibitory activity of benzotriazole derivatives. European journal of medicinal chemistry, 2017, Jan-27, Volume: 126 Topics: Molecular Docking Simulation; Protein Conformation; Sodium-Hydrogen Exchangers; Structure-Activity Relationship; Triazoles	2017
Na(+)-H+ exchange inhibition protects against mechanical, ultrastructural, and biochemical impairment induced by low concentrations of lysophosphatidylcholine in isolated rat hearts. Circulation research, 1997, Volume: 80, Issue:1 Topics: Acids; Amiloride; Animals; Guanidines; Heart; Hydrogen-Ion Concentration; In Vitro Techniques; Lysophosphatidylcholines; Male; Myocardium; Osmolar Concentration; Rats; Rats, Sprague-Dawley; Sodium-Hydrogen Exchangers; Stress, Mechanical; Sulfones	1997
Effect of sodium-hydrogen exchange inhibition on functional and metabolic impairment produced by oxidative stress in the isolated rat heart. Canadian journal of physiology and pharmacology, 1997, Volume: 75, Issue:4 Topics: Amiloride; Animals; Free Radicals; Glycogen; Guanidines; Heart; Hydrogen Peroxide; In Vitro Techniques; Lactic Acid; Male; Myocardium; Oxidants; Oxidative Stress; Purines; Rats; Rats, Sprague-Dawley; Sodium-Hydrogen Exchangers; Sulfones; Xanthine Oxidase	1997
S3226, a novel inhibitor of Na+/H+ exchanger subtype 3 in various cell types. Pflugers Archiv : European journal of physiology, 1998, Volume: 436, Issue:5 Topics: Amiloride; Animals; Cell Line; Dose-Response Relationship, Drug; Guanidines; Humans; Ion Channels; Methacrylates; Mice; Microvilli; Opossums; Rabbits; Rats; Sodium-Hydrogen Exchanger 3; Sodium-Hydrogen Exchangers; Stereoisomerism; Sulfones; Swine	1998
Regulation of apical membrane Na+/H+ exchangers NHE2 and NHE3 in intestinal epithelial cell line C2/bbe. The American journal of physiology, 1998, Volume: 275, Issue:3 Topics: Amiloride; Cell Line; Cell Membrane; Cyclic AMP; Cyclic GMP; Guanidines; Humans; Intestinal Mucosa; Kinetics; Phenotype; Recombinant Proteins; Second Messenger Systems; Sodium; Sodium-Hydrogen Exchanger 3; Sodium-Hydrogen Exchangers; Sulfones; Tetradecanoylphorbol Acetate; Thapsigargin; Thionucleotides; Time Factors; Transfection	1998
Inhibition of Na+-H+ exchange impairs receptor-mediated albumin endocytosis in renal proximal tubule-derived epithelial cells from opossum. The Journal of physiology, 1999, Nov-01, Volume: 520 Pt 3 Topics: Amiloride; Animals; Binding Sites; Cell Membrane; Cytosol; Endocytosis; Endosomes; Epithelial Cells; Guanidines; Hydrogen-Ion Concentration; Kidney Tubules, Proximal; Lysosomes; Opossums; Propionates; Receptors, Cell Surface; Serum Albumin; Sodium; Sodium-Hydrogen Exchangers; Sulfones	1999
Sodium, hydrogen exchange type 1 and bile ductular secretory activity in the guinea pig. Hepatology (Baltimore, Md.), 2000, Volume: 31, Issue:3 Topics: Amiloride; Animals; Antiporters; Bile; Bile Ducts; Chloride-Bicarbonate Antiporters; Epithelial Cells; Guanidines; Guinea Pigs; Hypotonic Solutions; Keratins; Male; Perfusion; Secretin; Signal Transduction; Sodium-Hydrogen Exchangers; Sulfones	2000
Slowly inactivating component of sodium current in ventricular myocytes is decreased by diabetes and partially inhibited by known Na(+)-H(+)Exchange blockers. Journal of molecular and cellular cardiology, 2000, Volume: 32, Issue:7 Topics: Amiloride; Animals; Anti-Arrhythmia Agents; Cells, Cultured; Diabetes Mellitus, Experimental; Dose-Response Relationship, Drug; Guanidines; Heart Ventricles; Lysophosphatidylcholines; Male; Myocardium; Patch-Clamp Techniques; Rats; Rats, Wistar; Sodium Channels; Sodium-Hydrogen Exchangers; Streptozocin; Sulfones; Tetrodotoxin; Veratrine	2000
Comparison of the protective effects of ischemic preconditioning and the Na+/H+ exchanger blockade. Naunyn-Schmiedeberg's archives of pharmacology, 2000, Volume: 362, Issue:1 Topics: Adenosine Triphosphate; Amiloride; Animals; Anti-Arrhythmia Agents; Blood Pressure; Enzyme Inhibitors; Guanidines; In Vitro Techniques; Ischemic Preconditioning, Myocardial; Myocardial Contraction; Myocardium; Protein Kinase C; Rats; Sodium-Hydrogen Exchangers; Sulfones; Ventricular Function, Left	2000
Influence of ammonia on sodium absorption in rat proximal colon. Pflugers Archiv : European journal of physiology, 2000, Volume: 440, Issue:4 Topics: Amiloride; Ammonia; Animals; Chlorides; Colon; Guanidines; Intestinal Absorption; Male; Methacrylates; Rats; Rats, Sprague-Dawley; Sodium; Sodium-Hydrogen Exchangers; Sulfones	2000
Inhibition of NHE protects reoxygenated cardiomyocytes independently of anoxic Ca(2+) overload and acidosis. American journal of physiology. Heart and circulatory physiology, 2000, Volume: 279, Issue:5 Topics: Amiloride; Animals; Anti-Arrhythmia Agents; Calcium; Carrier Proteins; Cell Hypoxia; Cells, Cultured; Cytosol; Fluorescent Dyes; Guanidines; Hydrogen-Ion Concentration; Magnesium; Male; Myocardial Contraction; Myocardial Ischemia; Myocardium; Oxygen; Rats; Rats, Wistar; Sodium; Sodium-Bicarbonate Symporters; Sodium-Hydrogen Exchangers; Sulfones	2000
Na+-overload during ischemia and reperfusion in rat hearts: comparison of the Na+/H+-exchange blockers EIPA, HOE642 and EMD96785. Magma (New York, N.Y.), 2000, Volume: 11, Issue:1-2 Topics: Amiloride; Animals; Guanidines; In Vitro Techniques; Magnetic Resonance Spectroscopy; Myocardial Ischemia; Myocardial Reperfusion Injury; Rats; Sodium; Sodium-Hydrogen Exchangers; Sulfones	2000
NHE and ICAM-1 expression in hypoxic/reoxygenated coronary microvascular endothelial cells. American journal of physiology. Heart and circulatory physiology, 2001, Volume: 280, Issue:6 Topics: Amiloride; Animals; Anti-Arrhythmia Agents; Calcium; Carbocyanines; Cell Hypoxia; Cells, Cultured; Coronary Vessels; Endothelium, Vascular; Flow Cytometry; Guanidines; Hydrogen-Ion Concentration; Intercellular Adhesion Molecule-1; Lipoproteins, LDL; Male; Microcirculation; Myocardial Reperfusion Injury; Oxygen; Rats; Rats, Sprague-Dawley; RNA, Messenger; Sodium-Calcium Exchanger; Sodium-Hydrogen Exchangers; Sulfones	2001
Rapid acid extrusion response triggered by alpha(1) adrenoceptor in CHO cells. The Journal of physiology, 2001, Aug-15, Volume: 535, Issue:Pt 1 Topics: Acids; Adrenergic alpha-Agonists; Amiloride; Animals; CHO Cells; Cricetinae; Guanidines; Humans; Norepinephrine; Receptors, Adrenergic, alpha; Sodium-Hydrogen Exchangers; Sulfones	2001
Localization and functional characterization of Na+/H+ exchanger isoform NHE4 in rat thick ascending limbs. American journal of physiology. Renal physiology, 2001, Volume: 281, Issue:4 Topics: Amiloride; Animals; Anti-Arrhythmia Agents; Biological Transport; Fluorescent Antibody Technique; Guanidines; Isomerism; Loop of Henle; Membrane Proteins; Nephrons; Quaternary Ammonium Compounds; Rats; Rats, Sprague-Dawley; Sodium-Hydrogen Exchangers; Sulfones	2001
Dehydroascorbic acid uptake by coronary artery smooth muscle: effect of intracellular acidification. The Biochemical journal, 2002, Mar-01, Volume: 362, Issue:Pt 2 Topics: Adenosine Triphosphate; Amiloride; Animals; Anti-Arrhythmia Agents; Biological Transport; Carbon Radioisotopes; Cells, Cultured; Coronary Vessels; Dehydroascorbic Acid; Guanidines; Hydrogen-Ion Concentration; Kinetics; Muscle, Smooth, Vascular; Sulfones; Swine	2002
Cytostatic potential of novel agents that inhibit the regulation of intracellular pH. British journal of cancer, 2002, Jul-15, Volume: 87, Issue:2 Topics: Adenocarcinoma; Amiloride; Animals; Antineoplastic Agents; Breast Neoplasms; Cell Division; Chloride-Bicarbonate Antiporters; Drug Design; Drug Screening Assays, Antitumor; Guanidines; Humans; Hydrogen-Ion Concentration; Intracellular Fluid; Mammary Neoplasms, Experimental; Neoplasm Proteins; Sodium-Hydrogen Exchangers; Sulfones; Tumor Cells, Cultured; Tumor Stem Cell Assay	2002
Antifibrogenic effects of canrenone, an antialdosteronic drug, on human hepatic stellate cells. Gastroenterology, 2003, Volume: 124, Issue:2 Topics: Aldosterone; Amiloride; Calcium; Canrenone; Cell Division; Cell Movement; Cells, Cultured; Extracellular Matrix Proteins; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Guanidines; Humans; Hydrogen-Ion Concentration; Intracellular Membranes; Liver; Liver Cirrhosis; Mineralocorticoid Receptor Antagonists; Phosphatidylinositol 3-Kinases; Phosphorylation; Platelet-Derived Growth Factor; Protein-Tyrosine Kinases; Signal Transduction; Sodium-Hydrogen Exchangers; Sulfones; Thrombin	2003
Inhibition of erythrocyte cation channels and apoptosis by ethylisopropylamiloride. Naunyn-Schmiedeberg's archives of pharmacology, 2003, Volume: 367, Issue:4 Topics: Amiloride; Annexins; Apoptosis; Cations; Cell Size; Dose-Response Relationship, Drug; Erythrocytes; Guanidines; Humans; In Vitro Techniques; Ion Channels; Osmotic Pressure; Patch-Clamp Techniques; Sulfones	2003
Na+ overload during ischemia and reperfusion in rat hearts: comparison of the Na+/H+ exchange blockers EIPA, cariporide and eniporide. Molecular and cellular biochemistry, 2003, Volume: 250, Issue:1-2 Topics: Amiloride; Animals; Anti-Arrhythmia Agents; Calcium; Guanidines; Hydrogen-Ion Concentration; Ischemia; Magnetic Resonance Spectroscopy; Male; Myocardial Contraction; Myocardium; Perfusion; Phosphates; Rats; Rats, Wistar; Reperfusion Injury; Sodium; Sodium-Hydrogen Exchangers; Sulfones; Time Factors	2003
The many targets of aldosterone. Hypertension (Dallas, Tex. : 1979), 2004, Volume: 43, Issue:5 Topics: Aldosterone; Amiloride; Body Water; Cell Size; Endothelial Cells; Endothelium, Vascular; Guanidines; Humans; Hypertension; Ion Transport; Membrane Potentials; Potassium; Receptors, Mineralocorticoid; Sodium; Sodium-Hydrogen Exchangers; Spironolactone; Sulfones	2004
Intracellular acidification by inhibition of the Na+/H+-exchanger leads to caspase-independent death of cerebellar granule neurons resembling paraptosis. Cell death and differentiation, 2004, Volume: 11, Issue:7 Topics: Acidosis; Adenoviridae; Amiloride; Animals; Apoptosis; Caspases; Cell Survival; Cells, Cultured; Cerebellum; Cycloheximide; Dose-Response Relationship, Drug; Guanidines; Hydrogen-Ion Concentration; Neurons; Potassium; Protein Synthesis Inhibitors; Rats; Rats, Sprague-Dawley; Sodium-Hydrogen Exchangers; Sulfones	2004
Dual modes of 5-(N-ethyl-N-isopropyl)amiloride modulation of apical dipeptide uptake in the human small intestinal epithelial cell line Caco-2. Cellular and molecular life sciences : CMLS, 2005, Volume: 62, Issue:14 Topics: Amiloride; Analysis of Variance; Biological Transport; Caco-2 Cells; Cation Transport Proteins; Cell Survival; Dipeptides; Dose-Response Relationship, Drug; Epithelial Cells; Guanidines; Humans; Hydrogen-Ion Concentration; Intestine, Small; Membrane Potentials; Membrane Proteins; Methacrylates; Peptide Transporter 1; Protein Isoforms; Protons; Sodium; Sodium-Hydrogen Exchanger 1; Sodium-Hydrogen Exchanger 3; Sodium-Hydrogen Exchangers; Sulfones; Symporters	2005
17beta-estradiol increases volume, apical surface and elasticity of human endothelium mediated by Na+/H+ exchange. Cardiovascular research, 2006, Mar-01, Volume: 69, Issue:4 Topics: Amiloride; Cell Membrane; Cell Size; Cells, Cultured; Dose-Response Relationship, Drug; Elasticity; Endothelial Cells; Estradiol; Estrogen Receptor Modulators; Guanidines; Humans; Microscopy, Atomic Force; Progesterone; Sodium Channel Blockers; Sodium-Hydrogen Exchangers; Sulfones; Tamoxifen; Testosterone	2006
Modification of intracellular calcium concentration in cardiomyocytes by inhibition of sarcolemmal Na+/H+ exchanger. American journal of physiology. Heart and circulatory physiology, 2006, Volume: 291, Issue:6 Topics: Adenosine Triphosphatases; Amiloride; Animals; Anti-Arrhythmia Agents; Calcium; Calcium Channels, L-Type; Guanidines; Indoles; Male; Myocytes, Cardiac; Potassium Chloride; Rats; Rats, Sprague-Dawley; Ryanodine; Sarcolemma; Sodium-Hydrogen Exchangers; Sodium-Potassium-Exchanging ATPase; Sulfones	2006
Mechanisms of secretion-associated shrinkage and volume recovery in cultured rabbit parietal cells. American journal of physiology. Gastrointestinal and liver physiology, 2007, Volume: 292, Issue:3 Topics: Adenosine Triphosphatases; Amiloride; Animals; Carbachol; Cell Size; Cells, Cultured; Charybdotoxin; Chloride Channels; Chromans; Colforsin; Enzyme Inhibitors; Guanidines; Hydrogen-Ion Concentration; Imidazoles; Ion Channels; KCNQ1 Potassium Channel; Nitrobenzoates; Parietal Cells, Gastric; Potassium Channel Blockers; Rabbits; Sodium-Calcium Exchanger; Sodium-Hydrogen Exchangers; Sulfonamides; Sulfones	2007
Delay of acute intracellular pH recovery after acidosis decreases endothelial cell activation. Journal of cellular physiology, 2007, Volume: 211, Issue:2 Topics: Acidosis; Amiloride; Calcium; Cell Adhesion; Cells, Cultured; Chloride-Bicarbonate Antiporters; Cyclic AMP; Endothelial Cells; Endothelium, Vascular; Exocytosis; Guanidines; Histamine; Humans; Hydrogen-Ion Concentration; Interleukin-8; Intracellular Fluid; Kinetics; Linear Models; Methacrylates; P-Selectin; Platelet Adhesiveness; Reperfusion Injury; Sodium-Hydrogen Exchangers; Sulfones; Umbilical Veins; von Willebrand Factor	2007
Enhanced Na+/H+ exchange activity contributes to the pathogenesis of muscular dystrophy via involvement of P2 receptors. The American journal of pathology, 2007, Volume: 171, Issue:5 Topics: Adenosine Triphosphate; Amiloride; Animals; Calcium; Cations, Divalent; Cells, Cultured; Cricetinae; Guanidines; Ion Transport; Mice; Mice, Inbred mdx; Muscle Fibers, Skeletal; Muscular Dystrophy, Animal; Purinergic P2 Receptor Antagonists; Receptors, Purinergic P2; Sodium; Sodium-Calcium Exchanger; Sodium-Hydrogen Exchangers; Sulfones	2007
Oxidative stress and the genomic regulation of aldosterone-stimulated NHE1 activity in SHR renal proximal tubular cells. Molecular and cellular biochemistry, 2008, Volume: 310, Issue:1-2 Topics: Aldosterone; Amiloride; Animals; Cell Line; Cytochalasin B; Dactinomycin; Gene Expression Regulation; Genome; Guanidines; Hydrogen Peroxide; Hydrogen-Ion Concentration; Immunoblotting; Kidney Tubules, Proximal; Methacrylates; Mifepristone; Oxidative Stress; Protein Isoforms; Rats; Rats, Inbred SHR; Receptors, Mineralocorticoid; RNA, Messenger; Sodium-Hydrogen Exchanger 1; Sodium-Hydrogen Exchangers; Spironolactone; Sulfones	2008
HCO3(-) secretion by murine nasal submucosal gland serous acinar cells during Ca2+-stimulated fluid secretion. The Journal of general physiology, 2008, Volume: 132, Issue:1 Topics: Amiloride; Animals; Bicarbonates; Calcium Signaling; Carbachol; Cation Transport Proteins; Cell Size; Cells, Cultured; Chloride Channels; Chlorides; Cystic Fibrosis Transmembrane Conductance Regulator; Cytoplasm; Epithelial Cells; Exocrine Glands; Guanidines; Hydrogen-Ion Concentration; Mice; Mice, Inbred C57BL; Mice, Knockout; Nasal Mucosa; Niflumic Acid; Protein Isoforms; Sodium; Sodium Potassium Chloride Symporter Inhibitors; Sodium-Hydrogen Exchanger 1; Sodium-Hydrogen Exchangers; Sodium-Potassium-Chloride Symporters; Solute Carrier Family 12, Member 2; Sulfones	2008
Inhibition of Na+/H+ exchanger enhances low pH-induced L-selectin shedding and beta2-integrin surface expression in human neutrophils. American journal of physiology. Cell physiology, 2008, Volume: 295, Issue:5 Topics: Amiloride; Ammonium Chloride; CD11b Antigen; CD18 Antigens; Cell Membrane; Guanidines; Humans; Hydrogen-Ion Concentration; L-Selectin; Lactic Acid; Macrophage-1 Antigen; Metalloproteases; Neutrophils; p38 Mitogen-Activated Protein Kinases; Protease Inhibitors; Protein Kinase Inhibitors; Reperfusion Injury; Sodium-Hydrogen Exchangers; Sulfones; Time Factors	2008
pH regulating transporters in neurons from various chemosensitive brainstem regions in neonatal rats. American journal of physiology. Regulatory, integrative and comparative physiology, 2009, Volume: 297, Issue:5 Topics: 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid; Amiloride; Ammonium Chloride; Animals; Animals, Newborn; Anti-Arrhythmia Agents; Brain Stem; Female; Guanidines; Hydrogen-Ion Concentration; Hypercapnia; Locus Coeruleus; Male; Membrane Transport Proteins; Neurons; Rats; Rats, Sprague-Dawley; Sodium Channel Blockers; Sodium-Bicarbonate Symporters; Sodium-Hydrogen Exchanger 1; Sodium-Hydrogen Exchanger 3; Sodium-Hydrogen Exchangers; Solitary Nucleus; Sulfones	2009
Dual inhibition of sodium-mediated proton and calcium efflux triggers non-apoptotic cell death in malignant gliomas. Brain research, 2010, Dec-02, Volume: 1363 Topics: Amiloride; Aniline Compounds; Animals; Astrocytes; Brain Neoplasms; Calcium; Cell Death; Cell Line, Tumor; Cytosol; Glioma; Guanidines; Humans; Hypoxia-Ischemia, Brain; Ionomycin; Ionophores; Personal Space; Phenyl Ethers; Protons; Rats; Rats, Sprague-Dawley; Sodium; Sodium-Calcium Exchanger; Sodium-Hydrogen Exchanger 1; Sodium-Hydrogen Exchangers; Sulfones; Tumor Microenvironment	2010
Evidence for NHE3-mediated Na transport in sheep and bovine forestomach. American journal of physiology. Regulatory, integrative and comparative physiology, 2011, Volume: 301, Issue:2 Topics: Amiloride; Animals; Cattle; Epithelium; Guanidines; Protein Isoforms; Rumen; Sheep; Sodium; Sodium Channel Blockers; Sodium-Hydrogen Exchanger 3; Sodium-Hydrogen Exchangers; Sulfones	2011
Na(+)/H(+) exchanger inhibitor induces vasorelaxation through nitric oxide production in endothelial cells via intracellular acidification-associated Ca2(+) mobilization. Vascular pharmacology, 2013, Volume: 58, Issue:4 Topics: Amiloride; Animals; Aorta, Thoracic; Calcium; Calmodulin; Cattle; Endoplasmic Reticulum; Endothelial Cells; Guanidines; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase Type III; Rats; Rats, Wistar; Sodium-Hydrogen Exchangers; Sulfones; Vasodilation	2013
Intermittent Hypoxia Inhibits Na+-H+ Exchange-Mediated Acid Extrusion Via Intracellular Na+ Accumulation in Cardiomyocytes. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 2018, Volume: 46, Issue:3 Topics: Amiloride; Animals; Cell Hypoxia; Cells, Cultured; Female; Guanidines; Hydrogen-Ion Concentration; Male; Myocytes, Cardiac; Protein Kinase C; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Sodium; Sodium-Calcium Exchanger; Sulfones; Superoxide Dismutase	2018