carebastine has been researched along with piperidines in 35 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (2.86) | 18.7374 |
| 1990's | 12 (34.29) | 18.2507 |
| 2000's | 17 (48.57) | 29.6817 |
| 2010's | 4 (11.43) | 24.3611 |
| 2020's | 1 (2.86) | 2.80 |
| Authors | Studies |
|---|---|
| Liminana, R; Meredith, PA; Reid, JL; Vincent, J | 1 |
| Imano, K; Ishii, K; Karasawa, T; Nakamura, H; Seto, Y; Takeyama, K; Yakuo, I | 1 |
| Fujii, T; Matsuda, M; Mizuki, Y; Sakashita, M; Sekine, Y; Yamaguchi, T | 1 |
| Fujii, T; Hashizume, T; Matsuda, M; Nakashima, M; Sakashita, M; Sekine, Y; Uematsu, T; Yamaguchi, T | 1 |
| Amejima, H; Fujii, T; Hatoyama, T; Kagemoto, A; Matsumoto, S; Miyazaki, H; Nakao, M; Tanaka, K | 1 |
| Aranko, K; Kuitunen, T; Mattila, MJ | 1 |
| Breimer, DD; Bruno, R; Cohen, AF; Reinhoudt, JF; Schoemaker, HC; Van Rooij, J | 1 |
| Böttcher, H; Hochstätter, H; Liebig-Weber, A; Schwartz, H | 1 |
| Delpón, E; Franqueza, L; Gay, P; Tamargo, J; Valenzuela, C; Vicente, J | 1 |
| Roberts, DJ | 1 |
| Jansat, JM; Lastra, CF; Mariño, EL | 1 |
| Fischer, H; Gottschlich, R; Seelig, A | 1 |
| Iga, T; Kotaki, H; Ohtani, H; Sato, H; Sawada, Y | 1 |
| Abdelaziz, MM; Devalia, JL; Khair, OA | 1 |
| Fujikura, T; Shimosawa, T; Yakuo, I | 1 |
| Kingham, P | 1 |
| Kido, Y; Sai, Y; Tamai, I; Tsuji, A; Yamashita, J | 1 |
| Aubeneau, M; Gillen, M; Jan, C; Jensen, BK; Pandit, B; Rhodes, G; Rohatagi, S | 1 |
| Matsuda, M; Mizuki, Y; Terauchi, Y | 1 |
| Paakkari, I | 1 |
| Frank, H; George, G; Gillen, M; Lim, J; Rohatagi, SS | 1 |
| Fujisaki, Y; Itoh, Y; Oishi, R | 1 |
| Appajosyula, S; Gelfand, EW; Meeves, S | 1 |
| Buisson, D; Jaouen, M; Mazier, C; Sari, MA | 1 |
| Benitez, J; Caballero, MJ; Carrillo, JA; Gervasini, G; Vizcaino, S | 1 |
| Choi, CS; Choi, YK; Desta, Z; Kim, MG; Kim, MJ; Lee, DJ; Liu, KH; Shin, JG; Shon, JH; Yoon, YJ | 1 |
| Fujikura, T; Shimosawa, T; Yamauchi, Y | 1 |
| Noveck, RJ; Preston, RA; Swan, SK | 1 |
| Honda, A; Makino, T; Shimizu, H; Shimizu, T; Yamagishi, S; Zhao, Y | 1 |
| Acuto, G; De Luisi, A; Mangialardi, G; Ria, R; Ribatti, D; Vacca, A | 1 |
| Cha, IJ; Lee, SS; Liu, KH; Shin, JG; Shon, JH; Yeo, CW | 1 |
| Hong, SJ; Kang, JM; Lee, HW; Lee, KT; Lee, MJ; Seo, JH; Shim, W; Tak, SK; Yim, SV | 1 |
| Doi, H; Egawa, G; Kabashima, K; Miyachi, Y; Moniaga, CS | 1 |
| Fukui, H; Hattori, M; Mizuguchi, H; Ono, S | 1 |
| Kamura, S; Kawasaki, H; Murashima, A; Ozawa, K; Sago, H; Saito, J; Sandaiji, N; Suzuki, T; Wada, S; Yagishita, S; Yakuwa, N; Yamatani, A | 1 |
4 review(s) available for carebastine and piperidines
| Article | Year |
|---|---|
Towards the optimal antihistamine: studies with ebastine.
Topics: Animals; Bronchoconstriction; Butyrophenones; Guinea Pigs; Heart Diseases; Histamine H1 Antagonists; Piperidines; Potassium Channels; Rats; Structure-Activity Relationship; Terfenadine | 1998 |
Carebastine Almirall Prodesfarma.
Topics: Animals; Anti-Asthmatic Agents; Asthma; Butyrophenones; Clinical Trials as Topic; Contraindications; Drugs, Investigational; Humans; Piperidines; Structure-Activity Relationship | 2000 |
Cardiotoxicity of new antihistamines and cisapride.
Topics: Arrhythmias, Cardiac; Astemizole; Benzimidazoles; Butyrophenones; Cetirizine; Cisapride; Heart Diseases; Histamine H1 Antagonists; Humans; Loratadine; Piperidines; Serotonin Receptor Agonists; Terfenadine; Triprolidine | 2002 |
Anti-inflammatory activity of H1-receptor antagonists: review of recent experimental research.
Topics: Animals; Anti-Inflammatory Agents; Butyrophenones; Cells, Cultured; Histamine H1 Antagonists; Loratadine; Piperidines; Terfenadine | 2004 |
8 trial(s) available for carebastine and piperidines
| Article | Year |
|---|---|
The pharmacokinetics, antihistamine and concentration-effect relationship of ebastine in healthy subjects.
Topics: Adult; Butyrophenones; Dose-Response Relationship, Drug; Histamine H1 Antagonists; Humans; Hypersensitivity, Immediate; Male; Piperidines; Time Factors | 1988 |
Diazepam effects on the performance of healthy subjects are not enhanced by treatment with the antihistamine ebastine.
Topics: Administration, Oral; Adult; Analysis of Variance; Butyrophenones; Chromatography, High Pressure Liquid; Diazepam; Double-Blind Method; Drug Interactions; Female; Histamine H1 Antagonists; Humans; Male; Piperidines; Psychomotor Performance | 1993 |
Cimetidine does not influence the metabolism of the H1-receptor antagonist ebastine to its active metabolite carebastine.
Topics: Adult; Blood Pressure; Butyrophenones; Chromatography, High Pressure Liquid; Cimetidine; Drug Interactions; Half-Life; Heart Rate; Histamine H1 Antagonists; Humans; Male; Piperidines | 1993 |
Comparative study of different weighting methods in non-linear regression analysis: implications in the parametrization of carebastine after intravenous administration in healthy volunteers.
Topics: Adult; Area Under Curve; Butyrophenones; Histamine H1 Antagonists; Humans; Infusions, Intravenous; Linear Models; Male; Metabolic Clearance Rate; Pharmacology; Piperidines | 1998 |
Effect of age and gender on the pharmacokinetics of ebastine after single and repeated dosing in healthy subjects.
Topics: Administration, Oral; Adult; Age Factors; Aged; Aged, 80 and over; Area Under Curve; Butyrophenones; Drug Administration Schedule; Female; Histamine H1 Antagonists; Humans; Male; Mass Spectrometry; Middle Aged; Piperidines; Sex Factors | 2001 |
A double-blind, placebo-controlled study of the efficacy and safety of ebastine 20 mg once daily given with and without food in the treatment of seasonal allergic rhinitis.
Topics: Adolescent; Adult; Aged; Butyrophenones; Child; Double-Blind Method; Female; Food-Drug Interactions; Histamine H1 Antagonists; Humans; Male; Middle Aged; Piperidines; Rhinitis, Allergic, Seasonal; Severity of Illness Index; Treatment Outcome | 2002 |
Itraconazole and rifampin alter significantly the disposition and antihistamine effect of ebastine and its metabolites in healthy participants.
Topics: Adult; Antifungal Agents; Butyrophenones; Cross-Over Studies; Drug Interactions; Enzyme Inhibitors; Histamine; Histamine H1 Antagonists; Humans; Hypersensitivity, Immediate; Itraconazole; Male; Piperidines; Rifampin; Skin; Young Adult | 2010 |
Application of a rapid and selective method for the simultaneous determination of carebastine and pseudoephedrine in human plasma by liquid chromatography-electrospray mass spectrometry for bioequivalence study in Korean subjects.
Topics: Butyrophenones; Chromatography, High Pressure Liquid; Cisapride; Cross-Over Studies; Humans; Hydrogen-Ion Concentration; Male; Piperidines; Pseudoephedrine; Reproducibility of Results; Republic of Korea; Sensitivity and Specificity; Spectrometry, Mass, Electrospray Ionization; Therapeutic Equivalency; Young Adult | 2010 |
23 other study(ies) available for carebastine and piperidines
| Article | Year |
|---|---|
[Pharmacological study of ebastine, a novel histamine H1-receptor antagonist].
Topics: Administration, Oral; Animals; Butyrophenones; Disease Models, Animal; Dose-Response Relationship, Drug; Guinea Pigs; Histamine H1 Antagonists; Histamine Release; Humans; Hypersensitivity; In Vitro Techniques; Male; Phenothiazines; Piperidines; Pyrilamine; Rats; Rats, Wistar; Terfenadine | 1994 |
Comparative pharmacokinetics of the histamine H1-receptor antagonist ebastine and its active metabolite carebastine in rats, guinea pigs, dogs and monkeys.
Topics: Administration, Oral; Animals; Butyrophenones; Dogs; Guinea Pigs; Histamine H1 Antagonists; Injections, Intravenous; Macaca fascicularis; Male; Piperidines; Protein Binding; Rats; Rats, Wistar; Species Specificity | 1994 |
Pharmacokinetics of the H1-receptor antagonist ebastine and its active metabolite carebastine in healthy subjects.
Topics: Adult; Butyrophenones; Food; Half-Life; Histamine H1 Antagonists; Humans; Male; Middle Aged; Piperidines; Protein Binding | 1994 |
Absorption, distribution, metabolism and excretion of [14C]ebastine after a single administration in rats.
Topics: Administration, Oral; Animals; Autoradiography; Bile; Blood Proteins; Butyrophenones; Chromatography, Thin Layer; Feces; Female; Half-Life; Histamine H1 Antagonists; Humans; Injections, Intravenous; Intestinal Absorption; Male; Milk; Piperidines; Pregnancy; Protein Binding; Rats; Rats, Wistar; Tissue Distribution | 1994 |
Microbial oxidation of ebastine.
Topics: Biotransformation; Butyrophenones; Histamine H1 Antagonists; Mucorales; Oxidation-Reduction; Piperidines | 1996 |
Comparative effects of nonsedating histamine H1 receptor antagonists, ebastine and terfenadine, on human Kv1.5 channels.
Topics: Animals; Butyrophenones; Cells, Cultured; Drug Evaluation, Preclinical; Histamine H1 Antagonists; Humans; Membrane Potentials; Mice; Patch-Clamp Techniques; Piperidines; Potassium Channels; Terfenadine | 1997 |
Blood-brain barrier permeation: molecular parameters governing passive diffusion.
Topics: Air; Amiodarone; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Blood-Brain Barrier; Brain; Butyrophenones; Diffusion; Domperidone; Histamine H1 Antagonists; Humans; Kinetics; Loperamide; Micelles; Models, Biological; Piperidines; Surface Properties; Thermodynamics; Water | 1998 |
Pharmacokinetic-pharmacodynamic analysis of the arrhythmogenic potency of a novel antiallergic agent, ebastine, in rats.
Topics: Animals; Arrhythmias, Cardiac; Butyrophenones; Electrocardiography; Histamine H1 Antagonists; Male; Piperidines; Rats; Rats, Sprague-Dawley; Terfenadine | 1999 |
The potential of active metabolites of antihistamines in the management of allergic disease.
Topics: Anti-Inflammatory Agents; Butyrophenones; Cells, Cultured; Cetirizine; Chymases; Eosinophils; Granulocyte Colony-Stimulating Factor; Granulocyte-Macrophage Colony-Stimulating Factor; Hematopoietic Cell Growth Factors; Histamine; Histamine H1 Antagonists; Humans; Hypersensitivity; Intercellular Adhesion Molecule-1; Interleukin-3; Interleukin-8; Loratadine; Mast Cells; Piperidines; Potassium Channel Blockers; Potassium Channels; Prostaglandin D2; Pyridines; Recombinant Fusion Proteins; Recombinant Proteins; Serine Endopeptidases; Terfenadine; Time Factors; Tryptases | 2000 |
Regulatory effect of histamine H1 receptor antagonist on the expression of messenger RNA encoding CC chemokines in the human nasal mucosa.
Topics: Adult; Animals; Antigens; Butyrophenones; Chemokines, CC; Female; Gene Expression Regulation; Histamine; Histamine H1 Antagonists; Humans; Male; Mites; Nasal Mucosa; Piperidines; RNA, Messenger | 2001 |
Blood-brain barrier transport of H1-antagonist ebastine and its metabolite carebastine.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Blood-Brain Barrier; Butyrophenones; Cattle; Endothelium, Vascular; Histamine H1 Antagonists; Humans; Male; Mice; Mice, Mutant Strains; Piperidines; Rats; Rats, Sprague-Dawley; Tumor Cells, Cultured | 2000 |
Simultaneous determination of the histamine H1-receptor antagonist ebastine and its two metabolites, carebastine and hydroxyebastine, in human plasma using high-performance liquid chromatography.
Topics: Butyrophenones; Chromatography, High Pressure Liquid; Histamine H1 Antagonists; Humans; Piperidines; Reproducibility of Results; Sensitivity and Specificity | 2001 |
In vivo evidence for a lack of central effect of ebastine, an antihistaminic agent, in rats: a microdialysis study.
Topics: Animals; Butyrophenones; Chlorpheniramine; Corpus Striatum; Dopamine; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Histamine H1 Antagonists; In Vitro Techniques; Male; Microdialysis; Nomifensine; Piperidines; Rats; Rats, Wistar | 2002 |
Microbial oxidation of terfenadine and ebastine into fexofenadine and carebastine.
Topics: Absidia; Biotransformation; Butyrophenones; Cunninghamella; Histamine H1 Antagonists; Oxidation-Reduction; Piperidines; Streptomyces griseus; Terfenadine | 2004 |
The effect of CYP2J2, CYP3A4, CYP3A5 and the MDR1 polymorphisms and gender on the urinary excretion of the metabolites of the H-receptor antihistamine ebastine: a pilot study.
Topics: Administration, Oral; Adolescent; Adult; ATP Binding Cassette Transporter, Subfamily B, Member 1; Beverages; Body Weight; Butyrophenones; Citrus paradisi; Cytochrome P-450 CYP2J2; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Female; Genotype; Histamine H1 Antagonists; Humans; Male; Oxygenases; Pilot Projects; Piperidines; Polymorphism, Restriction Fragment Length; Sex Factors | 2006 |
Characterization of ebastine, hydroxyebastine, and carebastine metabolism by human liver microsomes and expressed cytochrome P450 enzymes: major roles for CYP2J2 and CYP3A.
Topics: Butyrophenones; Cytochrome P-450 CYP2J2; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Histamine H1 Antagonists; Humans; In Vitro Techniques; Microsomes, Liver; Oxygenases; Piperidines | 2006 |
The effect of H1 antagonists carebastine and olopatadine on histamine induced expression of CC chemokines in cultured human nasal epithelial cells.
Topics: Adolescent; Adult; Anti-Inflammatory Agents; Butyrophenones; Cells, Cultured; Chemokine CCL2; Chemokine CCL5; Chemokines, CC; Child; Dibenzoxepins; Dose-Response Relationship, Drug; Epithelial Cells; Female; Histamine; Histamine H1 Antagonists; Humans; Male; Middle Aged; Nasal Mucosa; Olopatadine Hydrochloride; Piperidines; Rhinitis; Rhinitis, Allergic, Perennial; Rhinitis, Allergic, Seasonal | 2007 |
Pharmacokinetics and safety of ebastine in healthy subjects and patients with renal impairment.
Topics: Administration, Oral; Adult; Aged; Area Under Curve; Butyrophenones; Drug Administration Schedule; Drug Monitoring; Electrocardiography; Female; Half-Life; Histamine H1 Antagonists; Humans; Kidney Function Tests; Male; Middle Aged; Piperidines; Renal Insufficiency | 2007 |
Carebastine, an H1-receptor antagonist, suppresses the expression of macrophage migration inhibitory factor.
Topics: Butyrophenones; Cells, Cultured; Histamine H1 Antagonists; Humans; Interleukin-6; Macrophage Migration-Inhibitory Factors; Monocytes; Piperidines; Tumor Necrosis Factor-alpha | 2008 |
Anti-angiogenic activity of carebastine: a plausible mechanism affecting airway remodelling.
Topics: Airway Remodeling; Animals; Anti-Asthmatic Agents; Butyrophenones; Capillaries; Cell Division; Cell Movement; Cells, Cultured; Chick Embryo; Chickens; Chorioallantoic Membrane; Endothelial Cells; Humans; Neovascularization, Pathologic; Phosphorylation; Piperidines; Proto-Oncogene Proteins c-akt; Pulmonary Artery; Receptors, Histamine H1; Signal Transduction; Umbilical Veins; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factor Receptor-2 | 2009 |
Histamine modulates the responsiveness of keratinocytes to IL-17 and TNF-α through the H1-receptor.
Topics: Butyrophenones; Cells, Cultured; Granulocyte-Macrophage Colony-Stimulating Factor; Histamine; Histamine H1 Antagonists; Humans; Inflammation; Inflammation Mediators; Interleukin-17; Interleukin-8; Keratinocytes; Piperidines; Receptors, Histamine H1; Tumor Necrosis Factor-alpha | 2011 |
Inverse agonistic activity of antihistamines and suppression of histamine H1 receptor gene expression.
Topics: Animals; Butyrophenones; CHO Cells; Cricetinae; Cricetulus; Drug Inverse Agonism; Gene Expression Regulation; HeLa Cells; Histamine Antagonists; Histamine H1 Antagonists; Humans; Inositol Phosphates; Piperazines; Piperidines; Pyrilamine; Receptors, Histamine H1; RNA, Messenger | 2012 |
Ebastine during pregnancy and lactation in a patient with chronic urticaria: ebastine and carebastine levels in maternal serum, cord blood, breast milk and the infant's serum.
Topics: Animals; Butyrophenones; Chronic Urticaria; Female; Fetal Blood; Histamine H1 Antagonists; Humans; Infant; Lactation; Milk, Human; Piperidines; Pregnancy | 2020 |