cardiovascular-agents has been researched along with lepadiformine* in 2 studies
2 other study(ies) available for cardiovascular-agents and lepadiformine
| Article | Year |
|---|---|
A new total synthesis of the marine tunicate alkaloid lepadiformine.
[reaction: see text]. A total synthesis of racemic lepadiformine has been achieved via a route that utilizes as key steps a novel stereocontrolled intramolecular spirocyclization of an allylsilane/N-acyliminium ion and the application of our radical-based methodology for production of N-acylimines from o-aminobenzamides. Topics: Alkaloids; Animals; Cardiovascular Agents; Crystallography, X-Ray; Cyclization; Indicators and Reagents; Urochordata | 2001 |
Total synthesis of (+/-)-lepadiformine via an amidoacrolein cycloaddition.
[reaction: see text]. The total synthesis of the cytotoxin lepadiformine is described. The intermolecular cycloaddition of a 2-amidoacrolein with the dimethyl acetal of 4,6-heptadienal gave a cycloadduct that was strategically functionalized for elaboration of the tricyclic ring system. These steps include a diastereoselective addition of an organoytterbium reagent to an aldehyde, cyclization to the trans-perhydroquinoline substructure via a Mitsunobu reaction, and an iodine-promoted amine cyclization with an alkene to introduce the pyrrolidine ring. Topics: Acrolein; Alkaloids; Animals; Cardiovascular Agents; Crystallography, X-Ray; Cyclization; Indicators and Reagents; Stereoisomerism; Urochordata | 2001 |