cardiovascular-agents and diallyl-disulfide

To investigate the therapeutic effects and mechanisms of garlicin for treatment of unstable angina pectoris (UAP), garlicin injectio was intravenously dripped 60 mg/day in 34 cases for 10 days. Nitroglycerine was used in 21 cases of the control group. The results showed that the total effective rates in improving symptoms and electrocardiogram after garlicin treatment were respectively 82% and 62%, and that the plasma endothelin and blood sugar levels were markedly lowered in cases with hyperglycemia.

Topics: Aged; Allyl Compounds; Angina, Unstable; Blood Glucose; Cardiovascular Agents; Disulfides; Endothelins; Female; Garlic; Humans; Hypoglycemic Agents; Infusions, Intravenous; Male; Middle Aged; Plant Extracts; Plants, Medicinal

The purposes of this study were to probe spectral behaviors of the toxic targets in trans-crotonaldehyde (TCA) in mitochondria altered by diallyl disulfides (DADS) derived from garlic. Ultraviolet absorption spectra showed that when ethanol as a solvent, the DADS blue shifted the peak of TCA from 318 nm to 312 nm. In mitochondria, the DADS further blue displaced the peak of TCA from 312 nm to 308 nm. Raman spectra displayed that the SS of DADS directly interacted with the CC toxic target of TCA, then the CCC of DADS interacted with the CHO toxic target of TCA. When DADS to TCA was 1:2, the DADS was the most powerful for the removal of the CC and CHO toxic targets of TCA. Study suggested that the SS of DADS altered the CC toxic target of TCA, while the CCC of DADS eliminated the CHO toxic target of TCA via local electron delocalization. The above two together clearly depicted the spectral behaviors of the toxic targets of TCA in mitochondria altered by DADS. These results are of great significance and value to elucidate the effects of garlic organic polysulfide on myocardial ischemia for the extensive development and use of garlic extracts.

Topics: Aldehydes; Allyl Compounds; Animals; Cardiovascular Agents; Cells, Cultured; Disulfides; Male; Mitochondria; Myocardial Ischemia; Myocardium; Rats; Rats, Wistar