cardiovascular-agents and 1-1--binaphthyl-2-2--diyl-hydrogen-phosphate

Selected water-soluble, native polysaccharides--such as amylose, laminaran, pullulan--and derivatized polysaccharides--methyl cellulose, hydroxypropyl cellulose, and carboxymethyl amylose sodium salt (CM-Am)--were investigated as chiral selectors in capillary electrophoresis. Effects of degree of polymerization and concentration of amylose on the separation of enantiomers of 1,1'-binaphthyl-2,2'-diyl hydrogen phosphate (BDHP) and a chiral cardiovascular drug cis-diltiazem were also studied. Pullulan and amyloses used in this study showed the same migration order for enantiomers of BDHP. In contrast, the migration order of BDHP enantiomers for cellulose derivatives and luminaran as well as with beta-cyclodextrin was opposite to that for amylose and pullulan. The enantioseparation of several chiral drugs was also performed using high-molecular-mass amylose (Am-4900) and CM-Am.

Topics: Amylose; Buffers; Cardiovascular Agents; Cyclodextrins; Diltiazem; Electrophoresis, Capillary; Glucans; Indicators and Reagents; Molecular Structure; Molecular Weight; Naphthalenes; Organophosphates; Polysaccharides; Solubility; Stereoisomerism; Water