cardamonin and tangeretin

cardamonin has been researched along with tangeretin* in 1 studies

Other Studies

1 other study(ies) available for cardamonin and tangeretin

ArticleYear
Inhibitory Effect of Tangeretin and Cardamonin on Human Intestinal SGLT1 Activity In Vitro and Blood Glucose Levels in Mice In Vivo.
    Nutrients, 2021, Sep-26, Volume: 13, Issue:10

    Rapid postprandial blood glucose elevation can cause lifestyle-related diseases, such as type II diabetes. The absorption of food-derived glucose is primarily mediated by sodium/glucose cotransporter 1 (SGLT1). Moderate SGLT1 inhibition can help attenuate postprandial blood glucose elevation and prevent lifestyle-related diseases. In this study, we established a CHO cell line stably expressing human SGLT1 and examined the effects of phytochemicals on SGLT1 activity. Among the 50 phytochemicals assessed, tangeretin and cardamonin inhibited SGLT1 activity. Tangeretin and cardamonin did not affect the uptake of L-leucine, L-glutamate, and glycyl-sarcosine. Tangeretin, but not cardamonin, inhibited fructose uptake, suggesting that the inhibitory effect of tangeretin was specific to the monosaccharide transporter, whereas that of cardamonin was specific to SGLT1. Kinetic analysis suggested that the suppression of SGLT1 activity by tangeretin was associated with a reduction in V

    Topics: Administration, Oral; Amino Acids; Animals; Blood Glucose; Caco-2 Cells; Chalcones; CHO Cells; Cricetulus; Flavones; Fructose; Humans; Intestines; Kinetics; Mice, Inbred ICR; Phytochemicals; Sarcosine; Sodium; Sodium-Glucose Transporter 1

2021