Page last updated: 2024-09-02

carboxyamido-triazole and triazoles

carboxyamido-triazole has been researched along with triazoles in 87 studies

Compound Research Comparison

Studies (carboxyamido-triazole)	Trials (carboxyamido-triazole)	Recent Studies (post-2010) (carboxyamido-triazole)	Studies (triazoles)	Trials (triazoles)	Recent Studies (post-2010) (triazoles)
105	15	22	25,808	2,252	13,501

Research

Studies (87)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	35 (40.23)	18.2507
2000's	38 (43.68)	29.6817
2010's	14 (16.09)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Kohn, EC; Liotta, LA; Sandeen, MA	1
Boltz, R; Cohen, CJ; Felix, J; Ham, E; Hupe, DJ; Miller, D; Soderman, D; Van Skiver, D	1
Felder, CC; Kohn, EC; Liotta, LA; Ma, AL	1
Barash, L; Beattie, T; Bochis, RJ; Brown, JE; Chabala, JC; Graham, DW; Harris, E; Peterson, LH; Tischler, M; Waksmunski, FS	1
Behrens, ND; Hupe, DJ; Peters, K; Pfefferkorn, ER	1
Kohn, EC; Liotta, LA	1
Behrens, ND; Boltz, R; Hupe, DJ	1
Cole, K; Kohn, EC; Sandeen, MA; Volpe, DA	1
Alessandro, R; Kohn, EC; Liotta, LA; Spoonster, J; Wersto, RP	1
Herenyiova, M; Weber, G; Yeh, YA	1
Ara, G; Chen, YN; Holden, SA; Korbut, TT; Northey, D; Teicher, BA	1
Chen, PS	1
Fink-Puches, R; Helige, C; Kerl, H; Smolle, J; Tritthart, HA	1
Day, A; Felder, CC; Freer, R; Holmes, KA; Jacobs, W; Kohn, EC; Liotta, LA	1
Christian, M; Cole, K; Davis, PA; Figg, WD; Goldspiel, B; Jacob, J; Kohn, EC; Link, CJ; Liotta, LA; Reed, E; Sarosy, G	1
Alessandro, R; Kohn, EC; Spoonster, J; Wersto, RP	1
Cole, KA; Kohn, EC; Soltis, MJ; Wersto, RP; Whittaker, N; Yeh, HJ	1
Lewis, RS; Nelson, WJ; Sjaastad, MD	1
Blackmore, PF; Kohn, EC; Palad, AJ; Rhim, JS; Schellhammer, PF; Somers, KD; Wasilenko, WJ; Wright, GL	1
Kuwano, M; Ono, M	1
Alberti, D; Arzoomanian, RZ; Berlin, J; Cleary, J; Feierabend, C; Hutson, P; Rago, RP; Tutsch, KD; Wilding, G	1
Hobson, S; Kohn, EC; Rodland, KD; Wersto, RP	1
Jacobs, W; Kohn, EC; Mikkelsen, T; Nelson, K; Rosenblum, ML; Smith, R	1
Bauer, KS; Davis, PA; Figg, WD; Kohn, EC; Liotta, LA; Reed, E; Sarosy, GA; Soltis, MJ; Thompkins, A	1
Alessandro, R; Biagini, G; Kohn, EC; Pugnaloni, A	1
Kohn, EC; Lambert, PA; Perry, RR; Somers, KD	1
Butscher, W; Cohen, M; Gardner, K; Kohn, EC; Liotta, L; Spriggs, N; Wersto, R; Yasui, H	1
Alessandro, R; Kohn, EC; Lapidos, K; Masiero, L; Spoonster, J	1
Blackmore, PF; Kohn, EC; Palad, AJ; Pincus, WA; Schechter, GL; Somers, KD; Spoonster, JR; Wasilenko, WJ; Wu, Y	1
Boudoulas, S; Cole, KA; Davis, PA; Figg, WD; Goldspiel, B; Jacob, J; Piscitelli, SC; Reed, E; Soltis, MJ; Steinberg, SM	1
Friedrich, MJ	1
Bu, W; Li, XM; Qin, LX; Tang, ZY; Xia, JL	1
Wiedemann, P	1
Bauer, KS; Davis, P; Figg, WD; Kohler, D; Kohn, EC; Lush, RM; Reed, E; Steinberg, SM	1
Bauer, KS; Dyer, V; Figg, WD; Hamilton, JM; Jones, EC; Linehan, WM; Pluda, JM; Premkumar, A; Reed, E; Steinberg, SM	1
Bauer, KS; Cude, KJ; Dixon, SC; Figg, WD; Kruger, EA	1
Divine, G; Ge, S; Mikkelsen, T; Rempel, SA	1
Huff, JL; Plopper, GE; Rust, WL	1
Blanchette, J; Doong, H; Gasbarre, C; Kim, YS; Kohn, E; Liotta, LA; Price, J; Probst, J; Rizzo, K	1
Bauer, KS; Bostick-Bruton, F; Figg, WD; Fuse, E; Goldspiel, B; Kohn, EC; Kulpa, V; Liotta, LA; Minasian, L; Noone, M; Pluda, J; Reed, E; Sarosy, GA; Tompkins, A	1
Figg, WD; Krüger, EA	1
Libutti, SK; Zogakis, TG	1
Alberti, D; Arzoomanian, RZ; Berlin, J; Binger, K; Dresen, A; Feierabend, C; Marnocha, R; Pluda, J; Tutsch, KD; Wilding, G	1
Alexander, HR; Costouros, NG; Feldman, AL; Figg, WD; Forbes, S; He, M; Kohn, EC; Kruger, EA; Libutti, SK; Liu, ET; Qian, M; Zogakis, TG	1
Faehling, M; Fellbrich, G; Föhr, KJ; Kroll, J; Mayr, U; Trischler, G; Waltenberger, J	1
Doong, H; Kassis, J; Kohn, EC; Patton, AM	1
Alaimo, G; Alessandro, R; Bauder, B; D'Amato, M; De Leo, G; Flugy, AM; Kohn, EC	1
Chiles, J; Kohn, EC; Moody, E; Moody, TW; Sieczkiewicz, GJ	1
Desai, S; Kohn, EC; Libutti, SK; Lorang, D; Oliver, VK; Patton, AM	1
Antoniotti, S; Fiorio Pla, A; Lovisolo, D; Mottola, A; Munaron, L; Pregnolato, S	1
Figg, WD; Hussain, MM; Kohn, EC; Kotz, H; Minasian, L; Oliver, VK; Premkumar, A; Raggio, M; Reed, E; Sarosy, G; Steinberg, SM; Zhai, S	1
He, S; Hoffmann, S; Wiedemann, P	1
DeMario, M; Desai, AA; Fleming, GF; Innocenti, F; Janisch, L; Ramirez, J; Ratain, MJ; Shepard, D	1
Franklin, AJ; Jetton, TL; Kohn, EC; Kuchemann, CL; Russell, SR	1
Capiod, T; Colosetti, P; Enfissi, A; Prigent, S	1
Apers, S; Baróniková, S; Cos, P; Pieters, L; Van Daele, A; Van Marck, E; Vanden Berghe, D; Vermeulen, P; Vlietinck, A	1
He, S; Hoffmann, S; Jin, ML; Kohn, EC; Masiero, L; Ryan, SJ; Wiedemann, P	1
Levy, FO; Mattingly, RR; Méthi, T; Norum, JH	1
Kohn, EC; Liotta, LA; Mehta, AI; Petricoin, EF; Winters, ME	1
Hollis, D; Mahoney, J; Ratain, MJ; Rini, B; Rosner, G; Small, E; Stadler, WM; Zaentz, SD	1
Dutcher, JP; Friedland, DM; Leon, L; Manola, J; Roth, B; Wilding, G	1
Brink, C; Capiod, T; Enfissi, A; Giovannucci, DR; Mignen, O; Nadkarni, A; Shuttleworth, TJ	1
Cruysberg, LP; Csaky, KG; Edelhauser, HF; Franklin, AJ; Kohn, EC; Robinson, MR; Sanders, J; Self, C; Yuan, P	1
Guo, L; Li, ZS; Wang, HL; Ye, CY; Zhang, DC	1
Borel, CO; Laskowitz, DT; Lombard, FW; Mesis, RG; Vitek, MP; Wang, H; Warner, DS; Yates, R	1
Alavi, JB; Carson, KA; Fisher, JD; Grossman, SA; Lush, R; Mikkelsen, T; Rosenfeld, S	1
Alessandro, R; Colomba, P; Corrado, C; De Leo, G; Flugy, AM; Fontana, S; Giordano, M; Kohn, EC; Santoro, A	1
Adjei, AA; Bauman, MD; Bernath, AM; Fitch, TR; Graham, DL; Hauge, MD; Hillman, SL; Jett, JR; Johnson, EA; Kugler, JW; Mandrekar, SJ; Marks, RS; Moore, DF; Perez, EA; Soori, GS; Windschitl, HE; Wos, EJ	1
Chen, W; Guo, L; Li, J; Yang, H; Ye, C; Ye, H; Yu, X; Zhang, D; Zheng, R	1
Antoniotti, S; Bussolati, B; Fiorio Pla, A; Grange, C; Merlino, A; Munaron, L; Tomatis, C	1
Friedlander, ML; Kohn, EC; Qu, XJ; Yang, JL; Yu, Y	1
Chen, WY; Guo, L; Hao, XJ; Jü, R; Li, J; Yang, HF; Yao, YR; Ye, CY; Ye, H; Yu, XL; Zhang, DC; Zheng, R	1
Afzal, A; Caballero, S; Edelhauser, H; Franklin, A; Geroski, D; Grant, MB; Hochhaus, G; Jurczyk, S; Kim, M; Palii, SS; Pardue, M; Shapiro, G	1
Azad, N; Figg, WD; Gardner, E; Graves, C; Imamura, CK; Kohn, EC; Kotz, H; Minasian, L; Perroy, A; Raggio, M; Sarosy, GA	1
Ballman, KV; Bot, B; Buckner, JC; DeMatteo, RP; Hillman, SL; Mandrekar, SJ; Nelson, H; Perez, EA; Sargent, DJ	1
Alessandro, R; Arlinghaus, R; Corrado, C; Flugy, AM; Fontana, S; Iovino, F; Kohn, EC; Leo, GD; Marfia, A; Raimondo, S; Santoro, A; Stassi, G	1
Guo, L; Ju, R; Li, J; Wu, D; Ye, C; Zhang, D	1
Guo, L; Hao, X; Ju, R; Li, J; Luo, L; Wang, C; Wu, D; Ye, C; Yu, X; Zhang, D; Zheng, R; Zhu, L	1
Alessandro, R; Corrado, C; De Leo, G; Flugy, AM; Guggino, G; Karmali, R; Raimondo, S; Taverna, S	1
Chen, C; Guo, L; Ju, R; Li, J; Luo, L; Ye, C; Yu, X; Zhang, D; Zhu, L	1
Chen, C; Chen, W; Guo, L; Li, J; Luo, L; Wu, D; Ye, C; Yu, X; Zhang, D; Zhu, L	1
Chen, C; Chen, W; Guo, L; Ju, R; Li, J; Ye, C; Yu, X; Zhang, D; Zhu, L	1
Chen, C; Chen, W; Du, XW; Guo, L; Li, J; Wu, DW; Ye, CY; Yu, XL; Zhang, DC; Zhu, L	1
Chen, C; Chen, W; Guo, L; Ju, R; Li, J; Ye, CY; Zhang, DC; Zhu, L	1
Chen, C; Chen, W; Du, X; Guo, L; Ju, R; Li, J; Wang, Y; Ye, C; Zhang, D; Zhu, L	1
Chen, C; Chen, W; Guo, L; Ju, R; Li, J; Shi, J; Sun, F; Ye, C; Zhang, D; Zhu, L	1
Chen, C; Fei, K; Guo, L; Ju, R; Li, J; Li, S; Ye, C; Zhang, D; Zhu, L	1

Reviews

4 review(s) available for carboxyamido-triazole and triazoles

Article	Year
Signal transduction as a therapeutic target. Current topics in microbiology and immunology, 1996, Volume: 213 ( Pt 3) Topics: Animals; Antineoplastic Agents; Calcium; Calcium Channel Blockers; Clinical Trials as Topic; Growth Substances; GTP-Binding Proteins; Humans; Ion Channel Gating; Ion Channels; Mice; Neoplasm Proteins; Neoplasms; Oncogenes; Phosphatidylinositol 3-Kinases; Phosphatidylinositol Diacylglycerol-Lyase; Phosphoric Diester Hydrolases; Phosphotransferases (Alcohol Group Acceptor); Protein Kinase C; Protein-Tyrosine Kinases; Proto-Oncogene Proteins p21(ras); Receptor Protein-Tyrosine Kinases; Signal Transduction; Triazoles	1996
[Development of anti tumor agents targeting angiogenesis]. Gan to kagaku ryoho. Cancer & chemotherapy, 1997, Volume: 24, Issue:2 Topics: Antineoplastic Agents; Clinical Trials as Topic; Cyclohexanes; Drug Screening Assays, Antitumor; Enzyme Inhibitors; Humans; Hydroxamic Acids; Interferon-alpha; Interleukin-12; Neoplasms; Neovascularization, Pathologic; O-(Chloroacetylcarbamoyl)fumagillol; Phenylalanine; Platelet Factor 4; Polysaccharides, Bacterial; Sesquiterpenes; Thalidomide; Thiophenes; Triazines; Triazoles; Tumor Cells, Cultured	1997
General aspects of anti-angiogenesis and cancer therapy. Expert opinion on biological therapy, 2001, Volume: 1, Issue:2 Topics: Angiogenesis Inhibitors; Animals; Antibodies; Clinical Trials as Topic; Collagen; Cyclohexanes; Endostatins; Endothelial Growth Factors; Fatty Acids, Unsaturated; Humans; Interleukin-12; Lymphokines; Matrix Metalloproteinase Inhibitors; Matrix Metalloproteinases; Neoplasms; O-(Chloroacetylcarbamoyl)fumagillol; Peptide Fragments; Receptor Protein-Tyrosine Kinases; Receptors, Growth Factor; Receptors, Vascular Endothelial Growth Factor; Receptors, Vitronectin; RNA, Catalytic; Sesquiterpenes; Suramin; Thalidomide; Triazoles; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors	2001
Calcium as a molecular target in angiogenesis. Current pharmaceutical design, 2003, Volume: 9, Issue:7 Topics: Calcium; Calcium Channel Blockers; Calcium Signaling; Cell Membrane; Humans; Neoplasms; Neovascularization, Pathologic; Neovascularization, Physiologic; Triazoles	2003

Trials

15 trial(s) available for carboxyamido-triazole and triazoles

Article	Year
Clinical investigation of a cytostatic calcium influx inhibitor in patients with refractory cancers. Cancer research, 1996, Feb-01, Volume: 56, Issue:3 Topics: Administration, Oral; Adult; Aged; Antineoplastic Agents; Calcium Channel Blockers; Female; Humans; Male; Middle Aged; Neoplasms; Triazoles	1996
Phase I clinical and pharmacokinetic study of oral carboxyamidotriazole, a signal transduction inhibitor. Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 1997, Volume: 15, Issue:2 Topics: Antineoplastic Agents; Capsules; Digestive System; Drug Administration Schedule; Female; Gels; Hematopoiesis; Humans; Male; Middle Aged; Neoplasms; Nervous System; Signal Transduction; Triazoles	1997
Phase I trial of micronized formulation carboxyamidotriazole in patients with refractory solid tumors: pharmacokinetics, clinical outcome, and comparison of formulations. Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 1997, Volume: 15, Issue:5 Topics: Adult; Aged; Antineoplastic Agents; Drug Administration Schedule; Drug Compounding; Female; Humans; Male; Middle Aged; Neoplasms; Triazoles	1997
Pharmacokinetics of orally administered carboxyamido-triazole, an inhibitor of calcium-mediated signal transduction. Clinical cancer research : an official journal of the American Association for Cancer Research, 1995, Volume: 1, Issue:8 Topics: Administration, Oral; Adult; Aged; Antineoplastic Agents; Calcium; Chemistry, Pharmaceutical; Dose-Response Relationship, Drug; Female; Humans; Male; Metabolic Clearance Rate; Middle Aged; Models, Biological; Neoplasms; Signal Transduction; Triazoles	1995
Pharmacokinetics and relative bioavailability of carboxyamido-triazole with respect to food and time of administration: use of a single model for simultaneous determination of changing parameters. Journal of pharmacokinetics and biopharmaceutics, 1998, Volume: 26, Issue:6 Topics: Adult; Antineoplastic Agents; Area Under Curve; Biological Availability; Cohort Studies; Cross-Over Studies; Female; Food-Drug Interactions; Humans; Male; Middle Aged; Neoplasms; Triazoles	1998
A pharmacokinetically guided Phase II study of carboxyamido-triazole in androgen-independent prostate cancer. Clinical cancer research : an official journal of the American Association for Cancer Research, 1999, Volume: 5, Issue:9 Topics: Adenocarcinoma; Aged; Androgens; Angiogenesis Inhibitors; Antineoplastic Agents; Humans; Male; Middle Aged; Neoplasms, Hormone-Dependent; Prostatic Neoplasms; Triazoles	1999
A phase I trial of carboxyamido-triazole and paclitaxel for relapsed solid tumors: potential efficacy of the combination and demonstration of pharmacokinetic interaction. Clinical cancer research : an official journal of the American Association for Cancer Research, 2001, Volume: 7, Issue:6 Topics: Adult; Aged; Animals; Antineoplastic Agents; Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Dose-Response Relationship, Drug; Drug Interactions; Female; Humans; Inhibitory Concentration 50; Male; Mice; Mice, Nude; Middle Aged; Neoplasms; Neovascularization, Pathologic; Ovarian Neoplasms; Paclitaxel; Recurrence; Time Factors; Treatment Outcome; Triazoles; Tumor Cells, Cultured	2001
Phase I and pharmacokinetic study of a micronized formulation of carboxyamidotriazole, a calcium signal transduction inhibitor: toxicity, bioavailability and the effect of food. Clinical cancer research : an official journal of the American Association for Cancer Research, 2002, Volume: 8, Issue:1 Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Biological Availability; Calcium; Calcium Channel Blockers; Capsules; Diet Therapy; Drug Administration Schedule; Female; Gels; Hematopoiesis; Humans; Intestinal Absorption; Male; Maximum Tolerated Dose; Middle Aged; Neoplasms; Nervous System; Triazoles	2002
Phase II trial of carboxyamidotriazole in patients with relapsed epithelial ovarian cancer. Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2003, Dec-01, Volume: 21, Issue:23 Topics: Administration, Oral; Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Biomarkers; Calcium Channel Blockers; Carcinoma, Endometrioid; Carcinoma, Papillary; Cystadenocarcinoma, Serous; Female; Humans; Middle Aged; Neoplasm Recurrence, Local; Neoplasms, Glandular and Epithelial; Ovarian Neoplasms; Salvage Therapy; Survival Rate; Treatment Outcome; Triazoles	2003
A phase I trial of pharmacokinetic modulation of carboxyamidotriazole (CAI) with ketoconazole in patients with advanced cancer. Cancer chemotherapy and pharmacology, 2004, Volume: 54, Issue:5 Topics: Adult; Aged; Antifungal Agents; Antineoplastic Agents; Capsules; Chemistry, Pharmaceutical; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Female; Humans; Ketoconazole; Male; Middle Aged; Neoplasms; Triazoles	2004
Successful implementation of the randomized discontinuation trial design: an application to the study of the putative antiangiogenic agent carboxyaminoimidazole in renal cell carcinoma--CALGB 69901. Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2005, Jun-01, Volume: 23, Issue:16 Topics: Adult; Aged; Aged, 80 and over; Angiogenesis Inhibitors; Antineoplastic Agents; Carcinoma, Renal Cell; Disease-Free Survival; Double-Blind Method; Female; Humans; Kidney Neoplasms; Male; Middle Aged; Neovascularization, Pathologic; Research Design; Survival Rate; Treatment Outcome; Triazoles	2005
Phase II study of carboxyamidotriazole in patients with advanced renal cell carcinoma refractory to immunotherapy: E4896, an Eastern Cooperative Oncology Group Study. Cancer, 2005, Dec-01, Volume: 104, Issue:11 Topics: Adult; Aged; Antineoplastic Agents; Carcinoma, Renal Cell; Disease Progression; Female; Humans; Kidney Neoplasms; Male; Middle Aged; Patient Selection; Time Factors; Treatment Outcome; Triazoles	2005
Phase II clinical and pharmacologic study of radiation therapy and carboxyamido-triazole (CAI) in adults with newly diagnosed glioblastoma multiforme. Investigational new drugs, 2007, Volume: 25, Issue:3 Topics: Administration, Oral; Adult; Aged; Anticonvulsants; Antineoplastic Agents; Brain Neoplasms; Calcium Channel Blockers; Case-Control Studies; Chemotherapy, Adjuvant; Drug Interactions; Glioblastoma; Humans; Kaplan-Meier Estimate; Middle Aged; Radiotherapy, Adjuvant; Treatment Outcome; Triazoles; United States	2007
Phase III randomized, double-blind study of maintenance CAI or placebo in patients with advanced non-small cell lung cancer (NSCLC) after completion of initial therapy (NCCTG 97-24-51). Lung cancer (Amsterdam, Netherlands), 2008, Volume: 60, Issue:2 Topics: Aged; Antineoplastic Agents; Carcinoma, Non-Small-Cell Lung; Double-Blind Method; Female; Humans; Kaplan-Meier Estimate; Lung Neoplasms; Male; Middle Aged; Placebos; Quality of Life; Triazoles	2008
A phase I study of paclitaxel and continuous daily CAI in patients with refractory solid tumors. Cancer biology & therapy, 2009, Volume: 8, Issue:19 Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Interactions; Female; Humans; Male; Maximum Tolerated Dose; Middle Aged; Neoplasms; Paclitaxel; Treatment Outcome; Triazoles; Young Adult	2009

Other Studies

68 other study(ies) available for carboxyamido-triazole and triazoles

Article	Year
In vivo efficacy of a novel inhibitor of selected signal transduction pathways including calcium, arachidonate, and inositol phosphates. Cancer research, 1992, Jun-01, Volume: 52, Issue:11 Topics: Aminoimidazole Carboxamide; Animals; Antineoplastic Agents; Arachidonic Acids; Calcium; Cell Division; Cell Line; Cell Transformation, Neoplastic; Colonic Neoplasms; Female; Genes, ras; Humans; Inositol Phosphates; Melanoma; Mice; Mice, Nude; Neoplasm Transplantation; Ovarian Neoplasms; Rats; Signal Transduction; Transfection; Transplantation, Heterologous; Triazoles	1992
The inhibition of receptor-mediated and voltage-dependent calcium entry by the antiproliferative L-651,582. The Journal of biological chemistry, 1991, Jun-05, Volume: 266, Issue:16 Topics: Aminoimidazole Carboxamide; Animals; Antineoplastic Agents; Arachidonic Acids; Calcium; Calcium Channels; Guinea Pigs; Heart Atria; Ion Channel Gating; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Rats; Triazoles	1991
The antiproliferative and antimetastatic compound L651582 inhibits muscarinic acetylcholine receptor-stimulated calcium influx and arachidonic acid release. The Journal of pharmacology and experimental therapeutics, 1991, Volume: 257, Issue:3 Topics: Aminoimidazole Carboxamide; Animals; Antineoplastic Agents; Arachidonic Acid; Arachidonic Acids; Calcium; Carbachol; Cell Division; Cell Line; Cyclic AMP; Inositol Phosphates; Kinetics; Receptors, Muscarinic; Transfection; Triazoles	1991
Benzylated 1,2,3-triazoles as anticoccidiostats. Journal of medicinal chemistry, 1991, Volume: 34, Issue:9 Topics: Alkylation; Aminoimidazole Carboxamide; Animals; Antineoplastic Agents; Chickens; Coccidiostats; Eimeria; Female; Ovarian Neoplasms; Triazoles	1991
L-651,582 inhibition of intracellular parasitic protozoal growth correlates with host-cell directed effects. The Journal of pharmacology and experimental therapeutics, 1991, Volume: 256, Issue:2 Topics: Adenosine Triphosphate; Aminoimidazole Carboxamide; Animals; Antiprotozoal Agents; Calcium; Culture Techniques; Eimeria; Humans; Hypoxanthine; Hypoxanthines; Toxoplasma; Triazoles	1991
L651582: a novel antiproliferative and antimetastasis agent. Journal of the National Cancer Institute, 1990, Jan-03, Volume: 82, Issue:1 Topics: Aminoimidazole Carboxamide; Animals; Antineoplastic Agents; Cell Adhesion; Cell Division; Cell Movement; Female; GTP-Binding Proteins; Humans; Imidazoles; Mice; Neoplasm Metastasis; Phosphatidylinositols; Rats; Triazoles; Tumor Cells, Cultured	1990
Anti-proliferative activity of L-651,582 correlates with calcium-mediated regulation of nucleotide metabolism at phosphoribosyl pyrophosphate synthetase. Journal of cellular physiology, 1990, Volume: 144, Issue:3 Topics: Aminoimidazole Carboxamide; Animals; Antineoplastic Agents; Calcium; Calcium Radioisotopes; Cattle; Cell Division; Cell Line; Hypoxanthines; Imidazoles; Kidney; Nucleotides; Phosphotransferases; Ribose-Phosphate Pyrophosphokinase; Triazoles	1990
In vitro and in vivo myelotoxicity of CAI to human and murine hematopoietic progenitor cells. American journal of hematology, 1995, Volume: 50, Issue:4 Topics: Animals; Bone Marrow Cells; Cell Division; Erythroid Precursor Cells; Erythropoietin; Granulocyte-Macrophage Colony-Stimulating Factor; Granulocytes; Hematopoietic Stem Cells; Humans; Interleukin-3; Kinetics; Leukocyte Count; Macrophages; Mice; Platelet Count; Recombinant Proteins; Spleen; Triazoles	1995
Angiogenesis: role of calcium-mediated signal transduction. Proceedings of the National Academy of Sciences of the United States of America, 1995, Feb-28, Volume: 92, Issue:5 Topics: Aminoimidazole Carboxamide; Calcium; Calcium Channel Blockers; Cell Adhesion; Cell Division; Cell Movement; Cells, Cultured; Collagen; Drug Combinations; Endothelium, Vascular; Extracellular Matrix Proteins; Fibroblast Growth Factor 2; Gelatinases; Humans; In Vitro Techniques; Laminin; Matrix Metalloproteinase 2; Metalloendopeptidases; Neovascularization, Pathologic; Phosphotyrosine; Proteoglycans; Signal Transduction; Triazoles; Tyrosine	1995
Quercetin: synergistic action with carboxyamidotriazole in human breast carcinoma cells. Life sciences, 1995, Volume: 57, Issue:13 Topics: Aminoimidazole Carboxamide; Antineoplastic Agents; Breast Neoplasms; Cell Division; Cell Survival; Drug Synergism; Female; Humans; Quercetin; Signal Transduction; Triazoles; Tumor Cells, Cultured	1995
CAI: effects on cytotoxic therapies in vitro and in vivo. Cancer chemotherapy and pharmacology, 1994, Volume: 34, Issue:6 Topics: Aminoimidazole Carboxamide; Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Lewis Lung; Carmustine; Cisplatin; Cyclophosphamide; Fibrosarcoma; Mammary Neoplasms, Experimental; Melphalan; Mice; Triazoles; Tumor Cells, Cultured	1994
Biotechnology transfer at the National Institutes of Health. Quality assurance (San Diego, Calif.), 1993, Volume: 2, Issue:4 Topics: Aminoimidazole Carboxamide; Antineoplastic Agents; Biotechnology; Ethics, Medical; Humans; Industry; National Institutes of Health (U.S.); Paclitaxel; Proteins; Research; Research Support as Topic; Technology Transfer; Tissue Inhibitor of Metalloproteinase-2; Triazoles; United States	1993
Inhibition of melanoma cell directional migration in vitro via different cellular targets. Experimental dermatology, 1993, Volume: 2, Issue:1 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Aminoimidazole Carboxamide; Animals; Calcium Channel Blockers; Cell Division; Cell Movement; Dequalinium; Flunarizine; GTP-Binding Proteins; Isoquinolines; Melanoma, Experimental; Mice; Piperazines; Protein Kinase C; Signal Transduction; Tamoxifen; Triazoles; Tumor Cells, Cultured; Verapamil	1993
Structure-function analysis of signal and growth inhibition by carboxyamido-triazole, CAI. Cancer research, 1994, Feb-15, Volume: 54, Issue:4 Topics: Aminoimidazole Carboxamide; Animals; Antineoplastic Agents; Arachidonic Acid; Calcium; Cell Division; CHO Cells; Cricetinae; Cricetulus; Humans; Lung Neoplasms; Signal Transduction; Structure-Activity Relationship; Triazoles; Tumor Cells, Cultured	1994
Identification and characterization of human metabolites of CAI [5-amino-1-1(4'-chlorobenzoyl-3,5-dichlorobenzyl)-1,2,3-triazole- 4-carboxamide). Drug metabolism and disposition: the biological fate of chemicals, 1996, Volume: 24, Issue:7 Topics: Antineoplastic Agents; Arachidonic Acid; Ascitic Fluid; Benzoates; Calcium; Cell Division; Cell Line; Chromatography, High Pressure Liquid; Exudates and Transudates; Glucuronates; Glucuronidase; Humans; Lung; Triazoles; Tumor Cells, Cultured	1996
Mechanisms of integrin-mediated calcium signaling in MDCK cells: regulation of adhesion by IP3- and store-independent calcium influx. Molecular biology of the cell, 1996, Volume: 7, Issue:7 Topics: Adenosine Triphosphate; Animals; Calcium; Calcium Channel Blockers; Cell Adhesion; Cell Line; Dogs; Feedback; Inositol 1,4,5-Trisphosphate; Integrins; Ion Transport; Nickel; Oligopeptides; Signal Transduction; Triazoles	1996
Effects of the calcium influx inhibitor carboxyamido-triazole on the proliferation and invasiveness of human prostate tumor cell lines. International journal of cancer, 1996, Oct-09, Volume: 68, Issue:2 Topics: Antineoplastic Agents; Calcium; Cell Division; Humans; Male; Neoplasm Invasiveness; Prostate-Specific Antigen; Prostatic Neoplasms; Triazoles; Tumor Cells, Cultured; Tumor Stem Cell Assay	1996
Thapsigargin-induced gene expression in nonexcitable cells is dependent on calcium influx. Molecular endocrinology (Baltimore, Md.), 1997, Volume: 11, Issue:3 Topics: Animals; Calcium; Calcium Channel Blockers; Calcium-Calmodulin-Dependent Protein Kinases; Cell Line; Chloramphenicol O-Acetyltransferase; Endothelin-1; Enzyme Activation; Gene Expression Regulation; Genes, fos; Genes, Reporter; Imidazoles; Rats; Thapsigargin; Triazoles	1997
Inhibitory effects of CAI in glioblastoma growth and invasion. Journal of neuro-oncology, 1997, Volume: 32, Issue:2 Topics: Antineoplastic Agents; Brain Neoplasms; Cell Adhesion; Cell Division; Gelatinases; Glioblastoma; Humans; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Matrix Metalloproteinase Inhibitors; Metalloendopeptidases; Neoplasm Invasiveness; Triazoles; Tumor Cells, Cultured	1997
Regulation of cellular tyrosine phosphorylation by stimulatory and inhibitory muscarinic acetylcholine receptors. Experimental cell research, 1997, Jul-10, Volume: 234, Issue:1 Topics: Animals; Calcium Channel Blockers; Carbachol; CHO Cells; Cricetinae; Immunoblotting; Immunohistochemistry; Isoenzymes; Microscopy, Electron; Muscarinic Agonists; Phospholipase C gamma; Phosphorylation; Receptors, Muscarinic; Signal Transduction; Triazoles; Type C Phospholipases; Tyrosine	1997
Antiproliferative and antiinvasive effects of carboxyamido-triazole on breast cancer cell lines. Surgery, 1997, Volume: 122, Issue:2 Topics: Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Breast Neoplasms; Calcium Channel Blockers; Cell Survival; Collagenases; Drug Screening Assays, Antitumor; Female; Gelatinases; Humans; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Metalloendopeptidases; Neoplasm Invasiveness; Receptors, Estrogen; Triazoles; Tumor Cells, Cultured	1997
Selective inhibition of mitogen-induced transactivation of the HIV long terminal repeat by carboxyamidotriazole. Calcium influx blockade represses HIV-1 transcriptional activation. The Journal of biological chemistry, 1997, Nov-07, Volume: 272, Issue:45 Topics: Anti-HIV Agents; Calcium; Calcium Channel Blockers; DNA Probes; DNA, Viral; Dose-Response Relationship, Drug; Genes, Regulator; HIV Long Terminal Repeat; HIV-1; Humans; Jurkat Cells; Mitogens; NF-kappa B; Transcriptional Activation; Transfection; Triazoles	1997
Endothelial cell spreading on type IV collagen and spreading-induced FAK phosphorylation is regulated by Ca2+ influx. Biochemical and biophysical research communications, 1998, Jul-30, Volume: 248, Issue:3 Topics: Calcium; Calcium Channel Blockers; Cell Adhesion; Cell Adhesion Molecules; Cell Movement; Cells, Cultured; Collagen; Cytoskeletal Proteins; Endothelium, Vascular; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Humans; Imidazoles; Kinetics; Paxillin; Phosphoproteins; Phosphorylation; Protein-Tyrosine Kinases; Triazoles; Umbilical Veins	1998
Inhibition of head and neck squamous cell carcinoma growth and invasion by the calcium influx inhibitor carboxyamido-triazole. Clinical cancer research : an official journal of the American Association for Cancer Research, 1997, Volume: 3, Issue:11 Topics: Antineoplastic Agents; Calcium; Calcium Channel Blockers; Carcinoma, Squamous Cell; Cell Division; Cell Movement; Head and Neck Neoplasms; Humans; Kinetics; Neoplasm Invasiveness; Signal Transduction; Triazoles; Tumor Cells, Cultured	1997
Ovarian cancer investigators aim at cell signaling pathways. JAMA, 1999, Mar-17, Volume: 281, Issue:11 Topics: Animals; Antineoplastic Agents; Calcium Channel Blockers; Cell Division; Chromones; Enzyme Inhibitors; Female; Humans; Morpholines; Ovarian Neoplasms; Phosphoinositide-3 Kinase Inhibitors; Signal Transduction; Triazoles	1999
Effect of antiangiogenic agents on experimental animal models of hepatocellular carcinoma. Annals of the Academy of Medicine, Singapore, 1999, Volume: 28, Issue:1 Topics: Animals; Antineoplastic Agents; Cell Division; Cyclohexanes; Liver Neoplasms, Experimental; Mice; Mice, Nude; Neoplasm Metastasis; Neovascularization, Pathologic; O-(Chloroacetylcarbamoyl)fumagillol; Phenylalanine; Sesquiterpenes; Suramin; Thiophenes; Triazoles	1999
1998 Jules Gonin lecture of the Retina Research Foundation. Drug treatment of ocular neovascularization and proliferation. Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie, 1999, Volume: 237, Issue:6 Topics: Calcium Channel Blockers; Cell Adhesion; Cell Movement; Cell Survival; Daunorubicin; Humans; Immunotoxins; Integrins; Multicenter Studies as Topic; Peptides, Cyclic; Pigment Epithelium of Eye; Retinal Neovascularization; Triazoles; Vitreoretinopathy, Proliferative	1999
Carboxyamido-triazole inhibits angiogenesis by blocking the calcium-mediated nitric-oxide synthase-vascular endothelial growth factor pathway. The Journal of pharmacology and experimental therapeutics, 2000, Volume: 292, Issue:1 Topics: Animals; Aorta, Thoracic; Calcium Channel Blockers; Cell Division; Cells, Cultured; Dose-Response Relationship, Drug; Endothelial Growth Factors; Endothelium, Vascular; Humans; In Vitro Techniques; Lymphokines; Male; Microcirculation; Neovascularization, Pathologic; Nitric Oxide Synthase; Rats; Rats, Sprague-Dawley; Triazoles; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors	2000
Carboxyamido-triazole induces apoptosis in bovine aortic endothelial and human glioma cells. Clinical cancer research : an official journal of the American Association for Cancer Research, 2000, Volume: 6, Issue:4 Topics: Animals; Aorta; Apoptosis; Calcium Channel Blockers; Cattle; Cells, Cultured; DNA Fragmentation; Dose-Response Relationship, Drug; Endothelium, Vascular; Flow Cytometry; Glioma; Humans; In Situ Nick-End Labeling; Time Factors; Triazoles; Tumor Cells, Cultured	2000
Screening assay for promigratory/antimigratory compounds. Analytical biochemistry, 2000, Apr-10, Volume: 280, Issue:1 Topics: Antineoplastic Agents; Breast Neoplasms; Drug Screening Assays, Antitumor; Fluoresceins; Fluorescent Dyes; Humans; Neoplasm Metastasis; Propidium; Spectrometry, Fluorescence; Tamoxifen; Triazoles; Tumor Cells, Cultured	2000
CAIR-1/BAG-3 forms an EGF-regulated ternary complex with phospholipase C-gamma and Hsp70/Hsc70. Oncogene, 2000, Sep-07, Volume: 19, Issue:38 Topics: Adaptor Proteins, Signal Transducing; Amino Acid Sequence; Apoptosis Regulatory Proteins; Binding Sites; Calcium Channel Blockers; Carrier Proteins; Cell Line; Cloning, Molecular; Epidermal Growth Factor; HSP70 Heat-Shock Proteins; Humans; Isoenzymes; Molecular Sequence Data; Phospholipase C gamma; Phosphorylation; Triazoles; Type C Phospholipases	2000
Protein binding alters the activity of suramin, carboxyamidotriazole, and UCN-01 in an ex vivo rat aortic ring angiogenesis assay. Clinical cancer research : an official journal of the American Association for Cancer Research, 2001, Volume: 7, Issue:7 Topics: Alkaloids; Angiogenesis Inhibitors; Animals; Aorta, Thoracic; Biological Assay; Blood Proteins; Dose-Response Relationship, Drug; Humans; In Vitro Techniques; Male; Neovascularization, Pathologic; Protein Binding; Rats; Rats, Sprague-Dawley; Staurosporine; Suramin; Triazoles	2001
Microarray gene expression profiling of angiogenesis inhibitors using the rat aortic ring assay. BioTechniques, 2002, Volume: 33, Issue:3 Topics: Angiogenesis Inhibitors; Animals; Aorta, Thoracic; Endothelial Growth Factors; Gene Expression Profiling; Gene Expression Regulation; Male; Neovascularization, Physiologic; Oligonucleotide Array Sequence Analysis; Rats; Rats, Sprague-Dawley; Triazoles	2002
Essential role of calcium in vascular endothelial growth factor A-induced signaling: mechanism of the antiangiogenic effect of carboxyamidotriazole. FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2002, Volume: 16, Issue:13 Topics: Angiogenesis Inhibitors; Biological Transport; Calcium; Cell Division; Cell Line; Cell Nucleus; Cytosol; DNA-Binding Proteins; Endothelial Growth Factors; Endothelium, Vascular; Enzyme Activation; Humans; Inositol 1,4,5-Trisphosphate; Isoenzymes; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; NFATC Transcription Factors; Nitric Oxide; Nuclear Proteins; Phospholipase C gamma; Phosphorylation; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Signal Transduction; Transcription Factors; Triazoles; Type C Phospholipases; Tyrosine; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factor Receptor-2	2002
Role of calcium in E-selectin induced phenotype of T84 colon carcinoma cells. Biochemical and biophysical research communications, 2003, Feb-21, Volume: 301, Issue:4 Topics: Antineoplastic Agents; Calcium; Calcium Channel Blockers; Calcium Signaling; Cell Movement; Colonic Neoplasms; E-Selectin; Humans; Imidazoles; Phenotype; Phosphorylation; Recombinant Proteins; Triazoles; Tumor Cells, Cultured; Tyrosine	2003
CAI inhibits the growth of small cell lung cancer cells. Lung cancer (Amsterdam, Netherlands), 2003, Volume: 39, Issue:3 Topics: Animals; Antineoplastic Agents; Carcinoma, Small Cell; Cell Division; Dose-Response Relationship, Drug; Humans; Lung Neoplasms; Mice; Mice, Nude; Neoplasms, Experimental; Neovascularization, Pathologic; Transplantation, Heterologous; Triazoles; Tumor Cells, Cultured	2003
Regulation of the pro-angiogenic microenvironment by carboxyamido-triazole. Journal of cellular physiology, 2003, Volume: 197, Issue:1 Topics: Animals; Antineoplastic Agents; Cell Movement; Cell Transplantation; Culture Media; Endothelial Growth Factors; Endothelium, Vascular; Enzyme-Linked Immunosorbent Assay; Female; Humans; Hydrogen-Ion Concentration; Hypoxia-Inducible Factor 1, alpha Subunit; Immunoblotting; Immunohistochemistry; Intercellular Signaling Peptides and Proteins; Interleukin-8; Lymphokines; Melanoma; Mice; Neovascularization, Pathologic; Reverse Transcriptase Polymerase Chain Reaction; Transcription Factors; Transplantation, Heterologous; Triazoles; Tumor Cells, Cultured; Umbilical Veins; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors	2003
Control of endothelial cell proliferation by calcium influx and arachidonic acid metabolism: a pharmacological approach. Journal of cellular physiology, 2003, Volume: 197, Issue:3 Topics: Animals; Arachidonic Acid; Calcium; Calcium Channel Blockers; Calcium Signaling; Cattle; Cell Division; Cell Line; Endothelium, Vascular; Enzyme Inhibitors; Fibroblast Growth Factor 2; Lipoprotein Lipase; Lipoxygenase; Neovascularization, Physiologic; Phospholipase D; Phospholipases A; Phospholipases A2; Prostaglandin-Endoperoxide Synthases; Triazoles; Type C Phospholipases	2003
[Carboxyamido-triazole inhibits substeps of choroidal neovascularization on retinal pigment epithelial cells and choroidal endothelial cells in vitro]. Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft, 2004, Volume: 101, Issue:10 Topics: Antineoplastic Agents; Calcium Channel Blockers; Cell Division; Cell Line; Cell Movement; Choroid; Endothelium, Vascular; Humans; In Vitro Techniques; Macular Degeneration; Neovascularization, Pathologic; Pigment Epithelium of Eye; Signal Transduction; Triazoles	2004
CAI is a potent inhibitor of neovascularization and imparts neuroprotection in a mouse model of ischemic retinopathy. Investigative ophthalmology & visual science, 2004, Volume: 45, Issue:10 Topics: Angiogenesis Inhibitors; Animals; Animals, Newborn; Antineoplastic Agents; Disease Models, Animal; Fluorescein Angiography; Hyperoxia; In Situ Nick-End Labeling; Ischemia; Mice; Mice, Inbred C57BL; Microscopy, Confocal; Neuroprotective Agents; Proto-Oncogene Proteins c-bcl-2; Retinal Neovascularization; Retinal Vessels; Triazoles	2004
The blocking of capacitative calcium entry by 2-aminoethyl diphenylborate (2-APB) and carboxyamidotriazole (CAI) inhibits proliferation in Hep G2 and Huh-7 human hepatoma cells. Cell calcium, 2004, Volume: 36, Issue:6 Topics: Antineoplastic Agents; Boron Compounds; Calcium; Calcium Channel Blockers; Calcium Channels; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Proliferation; Dose-Response Relationship, Drug; Growth Inhibitors; Humans; Liver Neoplasms; Triazoles	2004
An ex-vivo angiogenesis assay as a screening method for natural compounds and herbal drug preparations. Planta medica, 2004, Volume: 70, Issue:10 Topics: Aesculus; Angiogenesis Inhibitors; Camellia sinensis; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Fibroblast Growth Factors; Humans; Neovascularization, Physiologic; Olea; Phytotherapy; Plant Extracts; Plants, Medicinal; Reproducibility of Results; Triazoles	2004
Carboxyamido-triazole modulates retinal pigment epithelial and choroidal endothelial cell attachment, migration, proliferation, and MMP-2 secretion of choroidal endothelial cells. Current eye research, 2005, Volume: 30, Issue:2 Topics: Animals; Apoptosis; Calcium Channel Blockers; Cattle; Cell Adhesion; Cell Count; Cell Movement; Cell Proliferation; Choroid; Collagen Type IV; Endothelium, Vascular; Enzyme-Linked Immunosorbent Assay; Fibroblast Growth Factor 2; Fibronectins; Humans; Laminin; Matrix Metalloproteinase 2; Pigment Epithelium of Eye; Triazoles; Vascular Endothelial Growth Factor A	2005
Endogenous expression and protein kinase A-dependent phosphorylation of the guanine nucleotide exchange factor Ras-GRF1 in human embryonic kidney 293 cells. The FEBS journal, 2005, Volume: 272, Issue:9 Topics: Animals; Calcium; Calcium Channel Blockers; Cell Line; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Enzyme Activation; Humans; Kidney; Mice; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Phosphorylation; ras-GRF1; Receptors, Serotonin; Serine; Serotonin; Triazoles	2005
Supra-additive growth inhibition by a celecoxib analogue and carboxyamido-triazole is primarily mediated through apoptosis. Cancer research, 2005, May-01, Volume: 65, Issue:9 Topics: Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Calcium Channel Blockers; Celecoxib; Cell Cycle; Cell Line, Tumor; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprostone; Drug Screening Assays, Antitumor; Drug Synergism; ErbB Receptors; Humans; Indoles; Membrane Proteins; Prostaglandin-Endoperoxide Synthases; Pyrazoles; Signal Transduction; Sulfonamides; Transcriptional Activation; Triazoles	2005
Carboxyamidotriazole-induced inhibition of mitochondrial calcium import blocks capacitative calcium entry and cell proliferation in HEK-293 cells. Journal of cell science, 2005, Dec-01, Volume: 118, Issue:Pt 23 Topics: Boron Compounds; Calcium; Calcium Channel Blockers; Cell Line; Cell Proliferation; Dose-Response Relationship, Drug; Humans; Intracellular Membranes; Ion Transport; Kidney; Mitochondria; Time Factors; Triazoles	2005
Effective transscleral delivery of two retinal anti-angiogenic molecules: carboxyamido-triazole (CAI) and 2-methoxyestradiol (2ME2). Retina (Philadelphia, Pa.), 2005, Volume: 25, Issue:8 Topics: 2-Methoxyestradiol; Angiogenesis Inhibitors; Biological Transport; Chromatography, High Pressure Liquid; Diffusion; Diffusion Chambers, Culture; Drug Delivery Systems; Estradiol; Humans; Middle Aged; Permeability; Sclera; Tissue Donors; Triazoles	2005
Carboxyamido-triazole inhibits proliferation of human breast cancer cells via G(2)/M cell cycle arrest and apoptosis. European journal of pharmacology, 2006, May-24, Volume: 538, Issue:1-3 Topics: Antineoplastic Agents; Apoptosis; Blotting, Western; Cell Cycle; Cell Division; Cell Line, Tumor; Cell Proliferation; Cell Survival; DNA, Neoplasm; Dose-Response Relationship, Drug; G2 Phase; Humans; Membrane Potentials; Mitochondrial Membranes; Proto-Oncogene Proteins c-bcl-2; Triazoles	2006
Dissociation between vasospasm and functional improvement in a murine model of subarachnoid hemorrhage. Neurosurgical focus, 2006, Sep-15, Volume: 21, Issue:3 Topics: Animals; Antihypertensive Agents; Apolipoproteins E; Behavior, Animal; Calcium Channel Blockers; Disease Models, Animal; Dose-Response Relationship, Drug; Male; Mice; Mice, Inbred C57BL; Middle Cerebral Artery; Neurologic Examination; Nimodipine; Peptides; Reaction Time; Rotarod Performance Test; Subarachnoid Hemorrhage; Treatment Outcome; Triazoles; Vasospasm, Intracranial	2006
Effects of carboxyamidotriazole on in vitro models of imatinib-resistant chronic myeloid leukemia. Journal of cellular physiology, 2008, Volume: 215, Issue:1 Topics: Apoptosis; Benzamides; Cell Line, Tumor; Cell Proliferation; Down-Regulation; Drug Resistance, Neoplasm; Enzyme Activation; Enzyme Inhibitors; Fusion Proteins, bcr-abl; Gene Expression Regulation, Neoplastic; Humans; Imatinib Mesylate; In Situ Hybridization, Fluorescence; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; MAP Kinase Signaling System; Molecular Probes; Phosphotyrosine; Piperazines; Pyrimidines; ras Proteins; Triazoles	2008
Anti-inflammatory and analgesic potency of carboxyamidotriazole, a tumorostatic agent. The Journal of pharmacology and experimental therapeutics, 2008, Volume: 325, Issue:1 Topics: Analgesics; Animals; Anti-Inflammatory Agents; Antineoplastic Agents; Arthritis; Capillary Permeability; Disease Models, Animal; Edema; Female; Granuloma; Interleukin-1; Male; Mice; Mice, Inbred ICR; Pain; Pain Measurement; Rats; Rats, Wistar; Triazoles; Tumor Necrosis Factor-alpha	2008
Arachidonic acid-induced Ca2+ entry is involved in early steps of tumor angiogenesis. Molecular cancer research : MCR, 2008, Volume: 6, Issue:4 Topics: Arachidonic Acid; Breast Neoplasms; Calcium; Calcium Signaling; Cell Proliferation; Cell Separation; Humans; Neovascularization, Pathologic; Triazoles; Tumor Cells, Cultured	2008
Selective sensitivity to carboxyamidotriazole by human tumor cell lines with DNA mismatch repair deficiency. International journal of cancer, 2008, Jul-15, Volume: 123, Issue:2 Topics: Antineoplastic Agents; Apoptosis; Calcium Channel Blockers; Cell Cycle; Cell Line, Tumor; Chromosomes, Human; Colonic Neoplasms; Colorimetry; DNA Mismatch Repair; Drug Screening Assays, Antitumor; Female; Fluorouracil; Humans; Male; Neoplasm Invasiveness; Neoplasms; Nifedipine; Ovarian Neoplasms; Prostatic Neoplasms; Transfection; Triazoles; Urinary Bladder Neoplasms	2008
[Anti-inflammatory and analgesic potency of carboxyamidotriazole, a tumoristatic agent]. Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae, 2009, Volume: 31, Issue:3 Topics: Analgesics; Animals; Anti-Inflammatory Agents; Drug Evaluation, Preclinical; Female; Male; Mice; Mice, Inbred ICR; Rats; Rats, Wistar; Triazoles	2009
Targeting retinal and choroid neovascularization using the small molecule inhibitor carboxyamidotriazole. Brain research bulletin, 2010, Feb-15, Volume: 81, Issue:2-3 Topics: 2-Hydroxypropyl-beta-cyclodextrin; Animals; Antineoplastic Agents; beta-Cyclodextrins; Bromodeoxyuridine; Cell Proliferation; Cells, Cultured; Choroidal Neovascularization; Collagen; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Combinations; Electroretinography; Epithelial Cells; Female; Humans; Injections, Intraocular; Laminin; Mice; Proteoglycans; Rabbits; Rats; Retina; Retinal Neovascularization; Retinal Vessels; Triazoles	2010
Evaluation of the value of attribution in the interpretation of adverse event data: a North Central Cancer Treatment Group and American College of Surgeons Oncology Group investigation. Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2010, Jun-20, Volume: 28, Issue:18 Topics: Adolescent; Adult; Adverse Drug Reaction Reporting Systems; Aged; Aged, 80 and over; Benzamides; Carcinoma, Non-Small-Cell Lung; Clinical Trials, Phase III as Topic; Double-Blind Method; Female; Gastrointestinal Stromal Tumors; Humans; Imatinib Mesylate; Lung Neoplasms; Male; Middle Aged; Piperazines; Placebos; Pyrimidines; Randomized Controlled Trials as Topic; Retrospective Studies; Survival Rate; Treatment Outcome; Triazoles; Young Adult	2010
Carboxyamidotriazole inhibits cell growth of imatinib-resistant chronic myeloid leukaemia cells including T315I Bcr-Abl mutant by a redox-mediated mechanism. Cancer letters, 2011, Jan-28, Volume: 300, Issue:2 Topics: Animals; Antineoplastic Agents; Apoptosis; Benzamides; Blotting, Western; Cell Line, Tumor; Cell Proliferation; Drug Resistance, Neoplasm; Fusion Proteins, bcr-abl; Humans; Imatinib Mesylate; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Mice; Mutation; Oxidation-Reduction; Piperazines; Pyrimidines; Reactive Oxygen Species; Triazoles	2011
Inhibition of pro-inflammatory cytokines in tumour associated macrophages is a potential anti-cancer mechanism of carboxyamidotriazole. European journal of cancer (Oxford, England : 1990), 2012, Volume: 48, Issue:7 Topics: Animals; Anti-Inflammatory Agents; Antineoplastic Combined Chemotherapy Protocols; Arthritis, Experimental; Carcinoma, Lewis Lung; Coculture Techniques; Cytokines; Dexamethasone; Macrophages; Macrophages, Peritoneal; Male; Mice; Mice, Inbred C57BL; Neoplasm Transplantation; Neoplasms; Rats, Wistar; Triazoles; Tumor Microenvironment; Tumor Necrosis Factor-alpha	2012
Carboxyamidotriazole ameliorates experimental colitis by inhibition of cytokine production, nuclear factor-κB activation, and colonic fibrosis. The Journal of pharmacology and experimental therapeutics, 2012, Volume: 342, Issue:2 Topics: Animals; Colitis; Colon; Dextran Sulfate; Fibrosis; Inflammation; Inflammatory Bowel Diseases; Intercellular Adhesion Molecule-1; Interleukin-1beta; Interleukin-6; Macrophages, Peritoneal; Male; Mice; Mice, Inbred C57BL; Mucous Membrane; NF-kappa B; Phosphorylation; Proteolysis; Triazoles; Tumor Necrosis Factor-alpha	2012
Carboxyamidotriazole-orotate inhibits the growth of imatinib-resistant chronic myeloid leukaemia cells and modulates exosomes-stimulated angiogenesis. PloS one, 2012, Volume: 7, Issue:8 Topics: Animals; Antineoplastic Agents; Benzamides; Cell Adhesion; Cell Adhesion Molecules; Cell Line, Tumor; Cell Movement; Cell Proliferation; Drug Resistance, Neoplasm; Exosomes; Extracellular Signal-Regulated MAP Kinases; Fusion Proteins, bcr-abl; Gene Expression Regulation, Leukemic; Human Umbilical Vein Endothelial Cells; Humans; Imatinib Mesylate; Interleukin-8; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Male; Mice; Neovascularization, Pathologic; Orotic Acid; Phosphorylation; Phosphotyrosine; Piperazines; Proto-Oncogene Proteins c-akt; Pyrimidines; RNA, Messenger; Triazoles; Xenograft Model Antitumor Assays	2012
Carboxyamidotriazole: a novel inhibitor of both cAMP-phosphodiesterases and cGMP-phosphodiesterases. European journal of pharmacology, 2015, Jan-05, Volume: 746 Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Agents; Cell Line, Tumor; Cyclic AMP; Cyclic GMP; Intracellular Space; Male; Mice; Phosphodiesterase Inhibitors; Rats; Signal Transduction; Triazoles	2015
Activation of NALP1 inflammasomes in rats with adjuvant arthritis; a novel therapeutic target of carboxyamidotriazole in a model of rheumatoid arthritis. British journal of pharmacology, 2015, Volume: 172, Issue:13 Topics: Animals; Ankle Joint; Anti-Inflammatory Agents; Arthritis, Experimental; Arthritis, Rheumatoid; Cytokines; Inflammasomes; Male; Nerve Tissue Proteins; Radiography; Rats, Inbred Lew; Synovial Membrane; Triazoles	2015
Carboxyamidotriazole inhibits oxidative phosphorylation in cancer cells and exerts synergistic anti-cancer effect with glycolysis inhibition. Cancer letters, 2016, Jan-28, Volume: 370, Issue:2 Topics: Animals; Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Cell Proliferation; Deoxyglucose; Drug Synergism; Glucose; Glycolysis; Humans; Mice; Mice, Inbred C57BL; Oxidative Phosphorylation; Oxygen Consumption; Triazoles	2016
Therapeutic Effect of Carboxyamidotriazole on Adjuvant Arthritis in Rats. Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae, 2016, Volume: 38, Issue:1 Topics: Animals; Arthritis, Experimental; Freund's Adjuvant; Interleukin-1beta; Interleukin-6; Rats; Triazoles; Tumor Necrosis Factor-alpha	2016
Carboxyamidotriazole alleviates muscle atrophy in tumor-bearing mice by inhibiting NF-κB and activating SIRT1. Naunyn-Schmiedeberg's archives of pharmacology, 2017, Volume: 390, Issue:4 Topics: Adipose Tissue; Animals; Antineoplastic Agents; Cachexia; Carcinoma, Lewis Lung; Interleukin-6; Male; Mice, Inbred C57BL; Muscle, Skeletal; Muscular Atrophy; NF-kappa B; Sirtuin 1; Triazoles; Tumor Burden; Tumor Necrosis Factor-alpha	2017
Therapeutic efficacy of carboxyamidotriazole on 2,4,6-trinitrobenzene sulfonic acid-induced colitis model is associated with the inhibition of NLRP3 inflammasome and NF-κB activation. International immunopharmacology, 2017, Volume: 45 Topics: Animals; Cells, Cultured; Colitis; Colon; Cytokines; Female; Gene Expression Regulation; Humans; Inflammasomes; Inflammatory Bowel Diseases; Intestines; NF-kappa B; NLR Family, Pyrin Domain-Containing 3 Protein; Rats; Rats, Sprague-Dawley; Signal Transduction; Triazoles; Trinitrobenzenesulfonic Acid	2017
Carboxyamidotriazole Synergizes with Sorafenib to Combat Non-Small Cell Lung Cancer through Inhibition of NANOG and Aggravation of Apoptosis. The Journal of pharmacology and experimental therapeutics, 2017, Volume: 362, Issue:2 Topics: Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Carcinoma, Lewis Lung; Carcinoma, Non-Small-Cell Lung; Dose-Response Relationship, Drug; Drug Synergism; Lung Neoplasms; Male; Mice; Mice, Inbred C57BL; Nanog Homeobox Protein; Niacinamide; Phenylurea Compounds; Sorafenib; Triazoles; Xenograft Model Antitumor Assays	2017
Metabolic Mechanisms and a Rational Combinational Application of Carboxyamidotriazole in Fighting Pancreatic Cancer Progression after Chemotherapy. The Journal of pharmacology and experimental therapeutics, 2018, Volume: 367, Issue:1 Topics: Animals; Antineoplastic Agents; Aspartic Acid; Cell Line, Tumor; Cell Proliferation; Cell Respiration; Deoxyglucose; Disease Progression; Drug Interactions; Female; Glycolysis; Humans; Intracellular Space; Mice; Mice, Inbred BALB C; Mitochondria; Pancreatic Neoplasms; Triazoles; Xenograft Model Antitumor Assays	2018