carbonyl-3-chlorophenylhydrazone has been researched along with celastrol* in 1 studies
1 other study(ies) available for carbonyl-3-chlorophenylhydrazone and celastrol
| Article | Year |
|---|---|
The plant triterpenoid celastrol blocks PINK1-dependent mitophagy by disrupting PINK1's association with the mitochondrial protein TOM20.
A critical function of the PTEN-induced kinase 1 (PINK1)-Parkin pathway is to mediate the clearing of unhealthy or damaged mitochondria via mitophagy. Loss of either PINK1 or Parkin protein expression is associated with Parkinson's disease. Here, using a high-throughput screening approach along with recombinant protein expression and kinase, immunoblotting, and immunofluorescence live-cell imaging assays, we report that celastrol, a pentacyclic triterpenoid isolated from extracts of the medicinal plant Topics: HeLa Cells; HSP90 Heat-Shock Proteins; Humans; Hydrazones; Membrane Potential, Mitochondrial; Membrane Transport Proteins; Microtubules; Mitochondrial Precursor Protein Import Complex Proteins; Mitophagy; Pentacyclic Triterpenes; Polymerization; Protein Binding; Protein Kinases; Receptors, Cell Surface; Tripterygium; Triterpenes; Ubiquitin-Protein Ligases | 2019 |