carbon tetrachloride has been researched along with thioacetamide in 101 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 23 (22.77) | 18.7374 |
| 1990's | 12 (11.88) | 18.2507 |
| 2000's | 22 (21.78) | 29.6817 |
| 2010's | 38 (37.62) | 24.3611 |
| 2020's | 6 (5.94) | 2.80 |
| Authors | Studies |
|---|---|
| Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ | 1 |
| Glen, RC; Lowe, R; Mitchell, JB | 1 |
| Ekins, S; Williams, AJ; Xu, JJ | 1 |
| Miyazaki, M; Taketa, K; Watanabe, A | 1 |
| Bolt, HM; López del Pino, V | 1 |
| Craddock, VM; Henderson, AR | 1 |
| Guha, SK; Jänne, J; Pösö, H | 1 |
| Lin, J; Liu, C; Zhang, Q | 1 |
| Awad, JA; Badr, KF; Burk, RF; Kato, T; Morrow, JD; Roberts, LJ; Takahashi, K | 1 |
| Blankenship, LJ; Clawson, GA; Rhame, JG; Wilkinson, DS | 1 |
| Klaassen, CD; Liu, J; Madhu, C; Maziasz, TJ | 1 |
| Moore, L; Wright, PB | 1 |
| Büsser, MT; Lutz, WK | 1 |
| Kuroiwa, Y; Numazawa, S; Oguro, T; Yoshida, T | 1 |
| Abdulla, M; Bengmark, S; Dashti, H; Hägerstrand, I; Hultberg, B; Jeppsson, B; Srinivas, U | 1 |
| Huang, ZW | 1 |
| Inoue, K; Nakanishi, S; Nishiguchi, K; Yamazaki, H; Yasuyama, T | 1 |
| Bien, E; Witt, M | 1 |
| Landon, EJ; Naukam, RJ; Rama Sastry, BV | 1 |
| Siblíková, O; Trcka, V | 1 |
| Hölttä, E; Jänne, J; Sinervirta, R | 1 |
| Jeney, A; Kovács, L; Lapis, K; Szepesházi, K; Ujhelyi, E | 1 |
| Matsui, I; Pegg, AE | 1 |
| Albrecht, M; Siegers, CP; Younes, M | 1 |
| Pegg, AE; Persson, L | 1 |
| Cui, JC; Liu, AJ; Wang, BX | 1 |
| Sidransky, H; Verney, E | 1 |
| Pegg, AE; Perry, W | 1 |
| Breining, H; Strubelt, O | 1 |
| Chanda, S; Mehendale, HM | 1 |
| Mehendale, HM | 1 |
| Timbrell, JA; Waterfield, CJ | 1 |
| Abe, H; Kanda, T; Nakano, A | 1 |
| Mishra, SH; Rao, KS | 1 |
| Bachmann, R; Block, W; Dombrowski, F; Kreft, B; Pfeifer, U; Schild, H | 1 |
| Dhawan, BN; Saraswat, B; Visen, PK | 1 |
| Danz, M; Klinger, W; Lucas, N; Lupp, A | 1 |
| Kanelli, H; Koutselinis, AS; Margeli, AP; Spiliopoulou, CA; Theocharis, SE | 1 |
| Bae, IH; Jang, JJ; Jeong, DH; Jeong, KS; Kim, MR; Lee, JH; Lee, MJ; Lee, SJ; Lee, YS; Lim, IK | 1 |
| Jang, JJ; Jeong, DH; Lee, JH; Lee, MJ; Lee, SJ; Lee, YS; Lim, IK | 1 |
| Fuchs, U; Klinger, W; Lupp, A; Tralls, M | 1 |
| Apte, U; Mehendale, HM; Ramaiah, SK | 1 |
| REES, KR; SINHA, KP; SPECTOR, WG | 1 |
| AHMED, K; JUDAH, JD; MCLEAN, AE | 1 |
| Chen, Y; Li, YM; Lv, JY; Mei, XT; Xu, DH; Xu, SB | 1 |
| Kato, H; Katoh, M; Minami, K; Nakajima, M; Narahara, M; Saito, T; Sugiyama, H; Tomita, H; Yokoi, T | 1 |
| Baleshwar, M; Gupta, DK; Johri, RK; Mondhe, DM; Tasduq, SA | 1 |
| Balasubramanian, KA; Natarajan, SK; Pulimood, AB; Ramachandran, A; Thomas, S | 1 |
| Balasubramanian, KA; Basivireddy, J; Natarajan, SK; Pulimood, AB; Ramachandran, A; Ramamoorthy, P; Thomas, S | 1 |
| Asad, M; Kamath, JV; Y, J | 1 |
| Chan, ES; Chen, JF; Cronstein, BN; Delano, DL; Desai, A; Fernandez, P; Friedman, SL; Montesinos, MC; Pillinger, MH; Reiss, AB; Schwarzschild, MA; Yee, H | 1 |
| Harada, M; Ishikawa, M; Kubo, H; Nishitani, H | 1 |
| Asha, VV; Sheeba, MS; Suresh, V; Wills, PJ | 1 |
| Hashimoto, O; Inoue, K; Kumashiro, R; Murohara, T; Nakamura, T; Sakamoto, M; Sakata, R; Sata, M; Taniguchi, E; Torimura, T; Ueno, T | 1 |
| Antić-Stanković, J; Kotur-Stevuljević, J; Milenković, M; Stefanović, A; Topić, A; Uskoković-Marković, S | 1 |
| Bhardwaj, S; Gupta, DK; Johri, RK; Kumar, B; Mir, AI; Tasduq, SA | 1 |
| Demetter, P; Devière, J; Goffin, P; Gustot, T; Hols, P; Moreno, C; Nicaise, C; Prozzi, D; Quertinmont, E; Suain, V; Viaene, E | 1 |
| Amirtharaj, GJ; Balasubramanian, KA; Natarajan, SK; Pulimood, AB; Ramachandran, A | 1 |
| Flavell, RA; Gomes, DA; Hashmi, A; Jhandier, MN; Mahmood, S; Mehal, WZ; Nagata, J; Shi, Y; Sohail, MA; Sutterwala, FS; Watanabe, A | 1 |
| Muriel, P; Rivera-Espinoza, Y | 1 |
| Bang, YJ; Byun, HJ; Kim, W; Lee, HS; Lee, SH; Lee, SM; Myung, SJ; Yang, JI; Yoon, JH | 1 |
| Alhonen, L; Cerrada-Gimenez, M; Hyvönen, MT; Jänne, J; Keinänen, TA; Loimas, S; Pietilä, M; Pirinen, E | 1 |
| Bedrosian, AS; Cieza-Rubio, NE; Cohen, S; Connolly, MK; Frey, AB; Hassan, BU; Henning, JR; Ibrahim, J; Malhotra, A; Miller, G; Pachter, HL; Vera, V | 1 |
| Chen, SL; Cheng, HC; Han, WH; Ho, TC; Shih, SC; Tsao, YP; Wu, JY; Yang, SL | 1 |
| Brun, P; Buda, A; Castagliuolo, I; De Caro, R; Fabris, P; Giordani, MT; Grillo, AR; Macchi, V; Martines, D; Palù, G; Scarpa, M; Signori, S; Stefani, A | 1 |
| Brouillet, A; Chobert, MN; Couchie, D; Fourcot, A; Laperche, Y; Mavier, P; Zafrani, ES | 1 |
| Horiguchi, N; Ichikawa, T; Izumi, T; Kakizaki, S; Kishimoto, K; Mori, M; Ohyama, T; Sato, K; Takagi, H; Yamazaki, Y | 1 |
| Bilodeau, M; Bourbonnais, E; El-Leil, MS; Ethier, C; Meloche, S; Nguyen, BN; Raymond, VA | 1 |
| Fiel, MI; Ge, X; George, J; Leung, TM; Lopategi, A; Lu, Y; Nieto, N; Urtasun, R; Wang, X | 1 |
| Fiel, MI; Ge, X; Lu, Y; Mormone, E; Nieto, N | 1 |
| Czaja, MJ; Fiel, MI; Friedman, SL; Ghiassi-Nejad, Z; Gordon, R; Hernández-Gea, V; Rozenfeld, R; Yue, Z | 1 |
| Bugyik, E; Dezso, K; Nagy, P; Paku, S; Szurián, K; Turányi, E | 1 |
| Besner, GE; Brigstock, DR; Huang, G | 1 |
| Daniele, SM; Lardizábal, MN; Nocito, AL; Ornella, LA; Palatnik, JF; Veggi, LM | 1 |
| Galle, PR; He, YW; Kim, YO; Kohl, T; Longerich, T; Nagel, M; Schad, A; Schattenberg, JM; Schuchmann, M; Schuppan, D; Wörns, MA; Zimmermann, T | 1 |
| Chang, C; Huang, CK; Lai, KP; Lee, SO; Lin, TH; Luo, J; Ma, WL; Tsai, MY | 1 |
| Adil, HS; Afnan, Q; Bhushan, S; Farrukh, MR; Kaiser, PJ; Nissar, AU; Rafiq, RA; Subhash, BC; Tasduq, SA | 1 |
| Guldiken, N; Kucukoglu, O; Kulaksiz, H; Mueller, K; Mueller, S; Schwarz, P; Strnad, P; Stuetzle, M; Sunami, Y | 1 |
| Chen, J; Dong, L; Liu, J; Tu, X; Zang, Y; Zhang, H; Zhang, J; Zhang, Z; Zhu, J | 1 |
| Chen, J; Dong, L; Gao, Z; Hu, W; Huang, Z; Zang, Y; Zha, Y; Zhang, J; Zhang, Z | 1 |
| Daniele, SM; Lardizábal, MN; Nocito, AL; Palatnik, JF; Rodríguez, RE; Veggi, LM | 1 |
| Fürst, DO; Gonzalez-Carmona, MA; Görtzen, J; Granzow, M; Huss, S; Klein, S; Knolle, P; Kowallick, B; Krämer, B; Laleman, W; Linhart, M; Mazar, IG; Nattermann, J; Sauerbruch, T; Schierwagen, R; Schildberg, FA; Shah, VH; Siegmund, SV; Trebicka, J; Vogt, A; Werner, N; Wojtalla, A | 1 |
| Choi, MK; Han, JM; Kim, HG; Lee, JS; Park, HJ; Son, CG; Wang, JH | 1 |
| Cederbaum, AI; Gao, P; Hong, F; Lu, Y; Si, C; Xiong, H | 1 |
| Arteaga, M; Breslin, P; Cotler, SJ; Denning, MF; Ding, X; Lüscher, B; Qiu, W; Shang, N; Shimamura, T; Yong, S | 1 |
| Hsu, SM; Lee, TS; Liang, YC; Liao, CY; Liao, YJ; Lin, YL; Twu, YC; Wang, CK; Wang, YH | 1 |
| Itami, S; Kawada, N; Kuroda, M; Matsumoto, Y; Murakami, Y; Yoshizato, K | 1 |
| Chen, L; Liu, F; Liu, FF; Lu, YQ; Rao, HY; Ren, YY; Teng, X; Wei, L; Wu, N; Zhang, W | 1 |
| An, SY; Do, BR; Han, C; Han, J; Jang, YJ; Kim, JH; Kim, OH; Kim, SJ; Lee, G; Lee, J; Lim, HJ; Park, HK; Park, JY; Park, SY; Song, MJ | 1 |
| Kim, YO; Popov, Y; Schuppan, D | 1 |
| Bugyik, E; Dezső, K; Mózes, M; Nagy, P; Paku, S; Rókusz, A; Szücs, A; Veres, D | 1 |
| Fernández-Iglesias, A; Gracia-Sancho, J; Guixé-Muntet, S; Ortega-Ribera, M | 1 |
| Bao, Z; Dong, F; Hu, X; Huang, Y; Jiang, S; Jiang, X; Li, J; Wang, Y; Zhang, Z; Zhou, Q; Zhu, L | 1 |
| El-Mahmoudy, A; Gheith, I | 1 |
| Huang, C; Lei, KC; Leng, D; Sun, B; Sun, S; Zhang, XD | 1 |
| Chien, CY; Hsu, FY; Lee, YC; Liao, YJ; Wang, YH; Wu, CY | 1 |
| Ravichandra, A; Schwabe, RF | 1 |
| Choi, YJ; Hwang, J; Jun, DW; Kang, KW; Kim, H; Kim, HY; Kim, N; Kim, SK; Kim, YM; Lim, SC; Yoon, K | 1 |
| Anton, A; Campreciós, G; Delgado, TC; García-Calderó, H; García-Martínez, R; García-Pagán, JC; Garrabou, G; Gracia-Sancho, J; Guasch, E; Hernández-Gea, V; Lafoz, E; Martínez-Chantar, ML; Ruart, M; Vilaseca, M | 1 |
| Dias, ML; Dos Santos Goldenberg, RC; Faccioli, LAP; Paranhos, BA | 1 |
| Chen, TL; Chiu, WC; Hsu, FY; Lee, YC; Liao, YJ; Suk, FM | 1 |
3 review(s) available for carbon tetrachloride and thioacetamide
| Article | Year |
|---|---|
Injury and repair as opposing forces in risk assessment.
Topics: Animals; Carbon Tetrachloride; Dose-Response Relationship, Drug; Humans; Risk Assessment; Thioacetamide; Toxicology | 1995 |
Pharmacological actions of curcumin in liver diseases or damage.
Topics: Animals; Carbon Tetrachloride; Cholestasis; Curcuma; Curcumin; Humans; Iron; Liver; Liver Cirrhosis; Liver Cirrhosis, Biliary; Liver Diseases; Thioacetamide | 2009 |
Liver cirrhosis: An overview of experimental models in rodents.
Topics: Animals; Carbon Tetrachloride; Disease Models, Animal; Liver; Liver Cirrhosis; Liver Cirrhosis, Experimental; Models, Theoretical; Rodentia; Thioacetamide | 2022 |
1 trial(s) available for carbon tetrachloride and thioacetamide
| Article | Year |
|---|---|
The autoregulatory feedback loop of microRNA-21/programmed cell death protein 4/activation protein-1 (MiR-21/PDCD4/AP-1) as a driving force for hepatic fibrosis development.
Topics: Adult; Aged; Animals; Apoptosis Regulatory Proteins; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Female; Hepatic Stellate Cells; Humans; Liver Cirrhosis, Experimental; Male; Mice; Mice, Inbred ICR; MicroRNAs; Middle Aged; RNA-Binding Proteins; Signal Transduction; Thioacetamide; Transcription Factor AP-1; Transforming Growth Factor beta | 2013 |
97 other study(ies) available for carbon tetrachloride and thioacetamide
| Article | Year |
|---|---|
Developing structure-activity relationships for the prediction of hepatotoxicity.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; Tetracyclines; Thiophenes | 2010 |
Predicting phospholipidosis using machine learning.
Topics: Animals; Artificial Intelligence; Databases, Factual; Drug Discovery; Humans; Lipidoses; Models, Biological; Phospholipids; Support Vector Machine | 2010 |
A predictive ligand-based Bayesian model for human drug-induced liver injury.
Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands | 2010 |
Increased alpha1-fetoprotein production in rat liver injuries induced by various hepatotoxins.
Topics: alpha-Fetoproteins; Aminoacetonitrile; Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; DNA; Ethionine; Fetal Proteins; Glucosephosphate Dehydrogenase; Liver Diseases; Male; Rats; Thioacetamide | 1976 |
Effects of hepatotoxic agents on hepatic microsomal metabolism of estrogens in the rat.
Topics: Acetamides; Animals; Carbon Tetrachloride; Cytochrome P-450 Enzyme System; Estrogens; Ethanol; In Vitro Techniques; Male; Microsomes, Liver; Rats; Thioacetamide | 1977 |
De novo and repair replication of DNA in liver of carcinogen-treated animals.
Topics: Aflatoxins; Animals; Carbon Tetrachloride; Carcinogens; Diethylnitrosamine; DNA Repair; DNA Replication; Ethionine; Ethyl Methanesulfonate; Female; Liver; Plants, Toxic; Pyrrolizidine Alkaloids; Rats; Senecio; Thioacetamide; Time Factors | 1978 |
Stabilization of ornithine decarboxylase in rat liver.
Topics: Animals; Carbon Tetrachloride; Carboxy-Lyases; Cycloheximide; Drug Stability; Growth Hormone; Half-Life; Kinetics; Liver; Liver Regeneration; Male; Ornithine Decarboxylase; Rats; Thioacetamide | 1978 |
[Effect of the root of Polygonum multiflorum Thunb. and its processed products on fat accumulation in the liver of mice].
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Drugs, Chinese Herbal; Hot Temperature; Liver; Mice; Prednisone; Thioacetamide; Triglycerides | 1992 |
Formation of novel non-cyclooxygenase-derived prostanoids (F2-isoprostanes) in carbon tetrachloride hepatotoxicity. An animal model of lipid peroxidation.
Topics: Acetaminophen; Alanine Transaminase; Animals; Carbon Tetrachloride; Indomethacin; Isoniazid; Lipid Peroxides; Male; Phenobarbital; Prostaglandin-Endoperoxide Synthases; Prostaglandins; Rats; Rats, Inbred F344; Rats, Sprague-Dawley; Thioacetamide | 1992 |
Nuclear enlargement induced by hepatocarcinogens alters ploidy.
Topics: 2-Acetylaminofluorene; Animals; Carbon Tetrachloride; Cell Nucleus; Dimethylnitrosamine; Diploidy; Liver; Male; Polyploidy; Rats; Rats, Inbred Strains; Thioacetamide | 1992 |
The differential effects of hepatotoxicants on the sulfation pathway in rats.
Topics: 1-Naphthylisothiocyanate; 1-Propanol; Aflatoxin B1; Alanine Transaminase; Animals; Arylsulfotransferase; Bromobenzenes; Cadmium; Cadmium Chloride; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Cytosol; Dichloroethylenes; L-Iditol 2-Dehydrogenase; Liver; Liver Diseases; Male; Phosphoadenosine Phosphosulfate; Propanols; Rats; Rats, Inbred Strains; Sulfates; Thioacetamide | 1991 |
Potentiation of the toxicity of model hepatotoxicants by acetaminophen.
Topics: 1-Propanol; Acetaminophen; Alanine Transaminase; Animals; Bromobenzenes; Carbon Tetrachloride; Dichloroethylenes; Drug Synergism; Liver; Male; Models, Biological; Propanols; Rats; Rats, Inbred Strains; Thioacetamide; Time Factors | 1991 |
Stimulation of DNA synthesis in rat and mouse liver by various tumor promoters.
Topics: Adipates; Aflatoxin B1; Aflatoxins; Aldrin; Animals; Benzidines; Biological Availability; Carbon Tetrachloride; Carcinogens; Cell Division; Circadian Rhythm; DDT; Diethylhexyl Phthalate; DNA; DNA Replication; Female; Hexachlorocyclohexane; Isomerism; Liver; Liver Neoplasms; Male; Mice; Phenobarbital; Polychlorinated Dibenzodioxins; Rats; Thioacetamide | 1987 |
Synergistic induction of rat hepatic ornithine decarboxylase by multiple doses of cobalt chloride.
Topics: Animals; Carbon Tetrachloride; Cobalt; Cycloheximide; Drug Administration Schedule; Drug Synergism; Enzyme Induction; Injections, Subcutaneous; Kinetics; Liver; Male; Ornithine Decarboxylase; Rats; Rats, Inbred Strains; Reference Values; Thioacetamide | 1989 |
Thioacetamide- and carbon tetrachloride-induced liver cirrhosis.
Topics: Acetamides; Animals; Carbon Tetrachloride; Liver; Liver Cirrhosis, Experimental; Lysosomes; Male; Rats; Rats, Inbred Strains; Thioacetamide; Trace Elements | 1989 |
[Preliminary studies on effect of fruit juice of Actinidia chinensis Planch on experimental liver lesions in mice].
Topics: Alanine Transaminase; Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Female; Fruit; Liver; Male; Medicine, Chinese Traditional; Mice; Thioacetamide; Triglycerides | 1987 |
Effects of bromobenzene, thioacetamide and carbon tetrachloride on activities of alcohol dehydrogenase and aldehyde dehydrogenase of hepatic subcellular fractions in C57BL and DBA mice.
Topics: Acetamides; Alcohol Dehydrogenase; Aldehyde Dehydrogenase; Animals; Bromobenzenes; Carbon Tetrachloride; Liver; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Subcellular Fractions; Thioacetamide | 1987 |
Influence of pyrazolones on hepatic glutathione in rats.
Topics: 1-Propanol; Acetaminophen; Aminopyrine; Animals; Antipyrine; Carbon Tetrachloride; Cobalt; Female; Glutathione; Liver; Phenobarbital; Propanols; Pyrazoles; Rats; Rats, Inbred Strains; Thioacetamide | 1985 |
Effects of calcium channel blocking agents on calcium and centrilobular necrosis in the liver of rats treated with hepatotoxic agents.
Topics: Acetaminophen; Animals; Calcium; Calcium Channel Blockers; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Chloroform; Dimethylnitrosamine; Liver; Male; Microsomes, Liver; Necrosis; Rats; Rats, Inbred Strains; Thioacetamide | 1986 |
[Substance-induced liver injury as a model for evaluating hepatoprotective drugs].
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Disease Models, Animal; Drug Evaluation, Preclinical; Galactosamine; Liver Diseases; Rabbits; Rats; Rats, Inbred Strains; Thioacetamide | 1985 |
Synthesis and accumulation of polyamines in rat liver regenerating after treatment with carbon tetrachloride.
Topics: Animals; Carbon Radioisotopes; Carbon Tetrachloride; Carboxy-Lyases; Chromatography, Ion Exchange; Chromatography, Paper; Female; Growth Hormone; Hepatectomy; Liver; Liver Regeneration; Ornithine; Propylamines; Putrescine; Rats; S-Adenosylmethionine; Spermidine; Spermine; Thioacetamide; Time Factors; Transferases | 1973 |
Morphological and biochemical study of the hepatoprotective effect of AICA-phosphate.
Topics: Aminoimidazole Carboxamide; Animals; Carbon Tetrachloride; Imidazoles; Liver Cirrhosis, Experimental; Male; Microsomes, Liver; Purines; Rats; RNA; Thioacetamide | 1980 |
Effect of inhibitors of protein synthesis on rat liver spermidine N-acetyltransferase.
Topics: Acetyltransferases; Animals; Carbon Tetrachloride; Cycloheximide; Female; Liver; Models, Biological; Ornithine Decarboxylase; Protein Biosynthesis; Putrescine; Rats; RNA; Spermidine; Thioacetamide | 1981 |
Interrelation between lipid peroxidation and lysosomal enzyme release in the presence of carbon tetrachloride, cumene hydroperoxide or thioacetamide.
Topics: Acetamides; Animals; Benzene Derivatives; Carbon Tetrachloride; Catechin; Ditiocarb; Glucuronidase; Glutathione; Inactivation, Metabolic; Lipid Peroxides; Liver; Lysosomes; Male; Mixed Function Oxygenases; Rats; Rats, Inbred Strains; Thioacetamide | 1983 |
Studies of the induction of spermidine/spermine N1-acetyltransferase using a specific antiserum.
Topics: Acetyltransferases; Animals; Brain; Carbon Tetrachloride; Enzyme Induction; Immune Sera; Intestines; Kidney; Liver; Lung; Male; Mice; Mitoguazone; Organ Specificity; Pancreas; Prostate; Rats; Spermidine; Thioacetamide | 1984 |
[The effect of saponin isolated from stems and leaves of ginseng on experimental liver injury].
Topics: Animals; Carbon Tetrachloride; Fatty Liver; Liver; Male; Mice; Mice, Inbred Strains; Panax; Plants, Medicinal; Rats; Saponins; Sulfobromophthalein; Thioacetamide | 1983 |
Acute effects of selected hepatotoxic agents on polyribosomes and protein synthesis in the livers of rats fed purified diets containing hepatocarcinogens.
Topics: 2-Acetylaminofluorene; Acute Disease; Animals; Carbon Tetrachloride; Carcinogens; Chemical and Drug Induced Liver Injury; Dactinomycin; Diet; Ethionine; Hydrocortisone; Liver Neoplasms, Experimental; Methyldimethylaminoazobenzene; Polyribosomes; Protein Biosynthesis; Puromycin; Rats; Rats, Inbred Strains; Saline Solution, Hypertonic; Sparsomycin; Thioacetamide; Time Factors | 1982 |
Stimulation of transfer of methyl groups from O6-methylguanine in DNA to protein by rat liver extracts in response to hepatotoxins.
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; DNA; Guanine; Liver Extracts; Male; Methylation; Proteins; Rats; Rats, Inbred Strains; Thioacetamide; Time Factors | 1981 |
Influence of hypoxia on the hepatotoxic effects of carbon tetrachloride, paracetamol, allyl alcohol, bromobenzene and thioacetamide.
Topics: Acetaminophen; Allyl Compounds; Animals; Bromobenzenes; Carbon Tetrachloride; Ethanol; Hemodynamics; Hypoxia; Liver; Male; Rats; Thioacetamide | 1980 |
Nutritional impact on the final outcome of liver injury inflicted by model hepatotoxicants: effect of glucose loading.
Topics: Acetaminophen; Animals; Carbon Tetrachloride; Cell Division; Chloroform; Cytochrome P-450 Enzyme System; Death; DNA; Glucose; Liver; Male; Microsomes, Liver; Proliferating Cell Nuclear Antigen; Rats; Rats, Sprague-Dawley; Thioacetamide | 1995 |
Changes in taurine as an indicator of hepatic dysfunction and biochemical perturbations. Studies in vivo and in vitro.
Topics: Animals; Biomarkers; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Cells, Cultured; Clenbuterol; Galactosamine; Glutathione; Ketones; Liver; Liver Diseases; Male; Maleates; Necrosis; Phenobarbital; Rats; Rats, Sprague-Dawley; Taurine; Thioacetamide | 1996 |
Bone changes and mineral metabolism disorders in rats with experimental liver cirrhosis.
Topics: Animals; Bone and Bones; Calcium; Carbon Tetrachloride; Intestine, Small; Liver; Liver Cirrhosis, Experimental; Male; Osteoporosis; Rats; Rats, Wistar; Thioacetamide; Vitamin D | 1996 |
Antihepatotoxic activity of monomethyl fumarate isolated from Fumaria indica.
Topics: Acetaminophen; Alanine Transaminase; Alkaline Phosphatase; Animals; Aspartate Aminotransferases; Bilirubin; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Female; Fumarates; Galactosamine; Liver; Male; Maleates; Plant Extracts; Rats; Rats, Wistar; Rifampin; Silymarin; Thioacetamide | 1998 |
Evaluation of different models of experimentally induced liver cirrhosis for MRI research with correlation to histopathologic findings.
Topics: Animals; Carbon Tetrachloride; Carcinogens; Chronic Disease; Follow-Up Studies; Liver; Liver Cirrhosis, Experimental; Magnetic Resonance Imaging; Rats; Rats, Sprague-Dawley; Severity of Illness Index; Thioacetamide | 1999 |
Curative effect of picroliv on primary cultured rat hepatocytes against different hepatotoxins: an in vitro study.
Topics: Animals; Carbon Tetrachloride; Cell Survival; Cells, Cultured; Cinnamates; Dose-Response Relationship, Drug; Female; Galactosamine; Glycosides; Liver; Male; Plant Extracts; Rats; Thioacetamide; Vanillic Acid | 1998 |
Transplantation of fetal liver tissue suspension into the spleens of adult syngenic rats: effects of different cytotoxins on cytochrome P450 isoforms expression and on glycogen content.
Topics: Animals; Bromobenzenes; Carbon Tetrachloride; Cytochrome P-450 CYP1A1; Cytochrome P-450 CYP2B1; Cytochrome P-450 Enzyme System; Fetal Tissue Transplantation; Hepatocytes; Liver Glycogen; Organ Size; Propanols; Rats; Rats, Inbred F344; Spleen; Steroid Hydroxylases; Suspensions; Thioacetamide; Transplantation, Heterotopic | 2000 |
Metallothionein and heat shock protein expression during acute liver injury and regeneration in rats.
Topics: Animals; Carbon Tetrachloride; Heat-Shock Proteins; Immunohistochemistry; Liver; Liver Regeneration; Male; Metallothionein; Rats; Rats, Wistar; Thioacetamide | 2000 |
Subcellular redistribution of protein kinase C isozymes is associated with rat liver cirrhotic changes induced by carbon tetrachloride or thioacetamide.
Topics: Animals; Carbon Tetrachloride; Collagen; Enzyme Activation; Immunoblotting; Liver Cirrhosis; Male; Protein Kinase C; Rats; Rats, Inbred F344; Signal Transduction; Thioacetamide | 2001 |
Expression patterns of cell cycle-related proteins in a rat cirrhotic model induced by CCl4 or thioacetamide.
Topics: Animals; Carbon Tetrachloride; Cell Cycle Proteins; Disease Models, Animal; Liver Cirrhosis; Male; Rats; Rats, Inbred F344; Thioacetamide | 2001 |
Transplantation of fetal liver tissue suspension into the spleens of adult syngenic rats: effects of different cytotoxins on cytochrome P450 mediated monooxygenase functions and on oxidative state.
Topics: 7-Alkoxycoumarin O-Dealkylase; Animals; Bromobenzenes; Carbon Tetrachloride; Cytochrome P-450 CYP1A1; Cytochrome P-450 CYP2B1; Cytochrome P-450 Enzyme System; Cytotoxins; Ethylmorphine-N-Demethylase; Female; Fetal Tissue Transplantation; Glutathione; Hepatocytes; Lipid Peroxidation; Male; Pregnancy; Propanols; Rats; Rats, Inbred F344; Spleen; Thioacetamide | 2001 |
Cytochrome P4502E1 induction increases thioacetamide liver injury in diet-restricted rats.
Topics: Animals; Antioxidants; Blotting, Western; Body Weight; Carbon Tetrachloride; Carcinogens; Chemical and Drug Induced Liver Injury; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP2E1; Diet; Indoles; Male; Microsomes, Liver; Monoamine Oxidase; Organ Size; Rats; Rats, Sprague-Dawley; Thioacetamide | 2001 |
The pathogenesis of liver injury in carbon tetrachloride and thioacetamide poisoning.
Topics: Acetates; Amides; Anesthetics, Local; Carbon Tetrachloride; Liver; Thioacetamide | 1961 |
PROTECTION PROVIDED AGAINST CARBON TETRACHLORIDE AND THIOACETAMIDE POISONING BY STROPHANTHIN-G.
Topics: Amides; Bilirubin; Blood Chemical Analysis; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; Hepatitis; Hepatitis A; Isocitrate Dehydrogenase; Necrosis; Ouabain; Pathology; Pharmacology; Promethazine; Pyruvates; Rats; Research; Sulfhydryl Compounds; Thioacetamide; Toxicology; Transaminases | 1965 |
Protective effects of 5,4'-dihydroxy-3',5'-dimethoxy-7-O-beta-D -glucopyranosyloxy-flavone on experimental hepatic injury.
Topics: Acute Disease; Animals; Carbon Tetrachloride; Cells, Cultured; Disease Models, Animal; Flavones; Hepatocytes; Liver Cirrhosis; Male; Oryza; Phytotherapy; Plant Extracts; Rats; Rats, Sprague-Dawley; Thioacetamide | 2005 |
Relationship between hepatic gene expression profiles and hepatotoxicity in five typical hepatotoxicant-administered rats.
Topics: Acetaminophen; Alkaline Phosphatase; Animals; Bromobenzenes; Carbon Tetrachloride; Dimethylnitrosamine; Gene Expression Profiling; L-Lactate Dehydrogenase; Liver; Male; Rats; Rats, Sprague-Dawley; Thioacetamide | 2005 |
Reversal of fibrogenic events in liver by Emblica officinalis (fruit), an Indian natural drug.
Topics: Alanine Transaminase; Alkaline Phosphatase; Animals; Aspartate Aminotransferases; Carbon Tetrachloride; Catalase; Cytochrome P-450 CYP2E1; Glutathione; Glutathione Peroxidase; Lipid Peroxidation; Liver; Liver Cirrhosis; Male; Phyllanthus emblica; Plant Extracts; Rats; Rats, Wistar; Sodium-Potassium-Exchanging ATPase; Thioacetamide | 2005 |
Retinoid metabolism during development of liver cirrhosis.
Topics: Aging; Animals; Carbon Tetrachloride; Disease Progression; Female; Liver Cirrhosis, Experimental; Male; Rats; Rats, Wistar; Retinoids; Thioacetamide | 2005 |
Oxidative stress in the development of liver cirrhosis: a comparison of two different experimental models.
Topics: Animals; Biomarkers; Carbon Tetrachloride; Disease Models, Animal; Female; Liver Cirrhosis, Experimental; Male; Microsomes, Liver; Mitochondria; Mitochondrial Swelling; Oxidative Stress; Peroxisomes; Rats; Rats, Wistar; Thioacetamide | 2006 |
Effect of hexane extract of Boswellia serrata oleo-gum resin on chemically induced liver damage.
Topics: Acetaminophen; Animals; Anti-Inflammatory Agents; Boswellia; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Dose-Response Relationship, Drug; Hexanes; Liver; Liver Diseases; Necrosis; Organ Size; Plant Extracts; Protective Agents; Rats; Rats, Wistar; Resins, Plant; Silymarin; Thioacetamide | 2006 |
Adenosine A(2A) receptors play a role in the pathogenesis of hepatic cirrhosis.
Topics: Adenosine; Adenosine A2 Receptor Agonists; Animals; Blotting, Western; Caffeine; Carbon Tetrachloride; Cell Line; Chromatography, High Pressure Liquid; Ethanol; Hepatocytes; Humans; Liver Cirrhosis; Matrix Metalloproteinases, Membrane-Associated; Methotrexate; Mice; Mice, Inbred C57BL; Rats; Receptor, Adenosine A2A; Reverse Transcriptase Polymerase Chain Reaction; Thioacetamide; Triazines; Triazoles | 2006 |
Hemodynamic changes with liver fibrosis measured by dynamic contrast-enhanced MRI in the rat.
Topics: Animals; Aorta, Abdominal; Area Under Curve; Carbon Tetrachloride; Contrast Media; Gadolinium DTPA; Half-Life; Image Enhancement; Liver Circulation; Liver Cirrhosis, Experimental; Magnetic Resonance Imaging; Male; Rats; Rats, Wistar; Signal Processing, Computer-Assisted; Thioacetamide | 2006 |
Hepatoprotection of Phyllanthus maderaspatensis against experimentally induced liver injury in rats.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Dose-Response Relationship, Drug; Female; L-Lactate Dehydrogenase; Male; Phyllanthus; Phytotherapy; Plant Extracts; Protective Agents; Rats; Rats, Wistar; Thioacetamide | 2007 |
Significance and therapeutic potential of endothelial progenitor cell transplantation in a cirrhotic liver rat model.
Topics: Animals; Bone Marrow Cells; Carbon Tetrachloride; Cell Division; Cells, Cultured; Disease Models, Animal; Endothelial Cells; Graft Survival; Hepatocytes; In Situ Hybridization, Fluorescence; Liver Cirrhosis; Liver Regeneration; Male; Matrix Metalloproteinases; Rats; Rats, Wistar; RNA, Messenger; Stem Cell Transplantation; Thioacetamide; Tissue Inhibitor of Metalloproteinase-1; Up-Regulation | 2007 |
Protective effects of tungstophosphoric acid and sodium tungstate on chemically induced liver necrosis in wistar rats.
Topics: Acute Disease; Administration, Oral; Animals; Antioxidants; Carbon Tetrachloride; Disease Models, Animal; Female; Glutathione; Liver; Liver Function Tests; Necrosis; Oxidative Stress; Phosphoric Acids; Rats; Rats, Wistar; Thioacetamide; Tungsten Compounds | 2007 |
Reversal of hepatotoxin-induced pre-fibrogenic events by Emblica officinalis--a histological study.
Topics: Animals; Carbon Tetrachloride; Carcinogens; Drug Evaluation, Preclinical; Liver; Liver Cirrhosis; Phyllanthus emblica; Plant Extracts; Rats; Rats, Wistar; Thioacetamide; Toxins, Biological | 2007 |
Control of acute, chronic, and constitutive hyperammonemia by wild-type and genetically engineered Lactobacillus plantarum in rodents.
Topics: Acute Disease; Alanine; Ammonia; Animals; Carbon Tetrachloride; Chronic Disease; Disease Models, Animal; Hyperammonemia; Lactobacillus plantarum; Lactulose; Liver Failure; Male; Mice; Mice, Inbred C57BL; Probiotics; Rats; Rats, Inbred Lew; Thioacetamide | 2008 |
Retinoid metabolism in the small intestine during development of liver cirrhosis.
Topics: Alcohol Oxidoreductases; Animals; Biomarkers; Carbon Tetrachloride; Chromatography, High Pressure Liquid; Disease Progression; Down-Regulation; Enterocytes; Female; Intestine, Small; Liver Cirrhosis, Experimental; Male; Rats; Retinaldehyde; Retinoids; Thioacetamide; Time Factors; Tretinoin; Vitamin A | 2009 |
Inflammasome-mediated regulation of hepatic stellate cells.
Topics: Actins; Animals; Apoptosis Regulatory Proteins; Calcium Signaling; Carbon Tetrachloride; CARD Signaling Adaptor Proteins; Carrier Proteins; Cell Line, Transformed; Chemotaxis; Collagen Type I; Cytoskeletal Proteins; Gene Expression; Hepatic Stellate Cells; Humans; Inflammation; Inositol 1,4,5-Trisphosphate; Liver; Liver Cirrhosis; Mice; Mice, Inbred C57BL; Mice, Knockout; NLR Family, Pyrin Domain-Containing 3 Protein; Platelet-Derived Growth Factor; Thioacetamide; Transforming Growth Factor beta; Uric Acid | 2009 |
Synergistic antifibrotic efficacy of statin and protein kinase C inhibitor in hepatic fibrosis.
Topics: Animals; Apoptosis; Body Weight; Carbon Tetrachloride; Cell Line, Transformed; Disease Models, Animal; Drug Synergism; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Indoles; Liver Cirrhosis; Male; Mice; Mice, Inbred BALB C; Mitochondria; Organ Size; Pravastatin; Protein Kinase C; Protein Kinase Inhibitors; Thioacetamide | 2010 |
Continuous oxidative stress due to activation of polyamine catabolism accelerates aging and protects against hepatotoxic insults.
Topics: Acetyltransferases; Aging; Animals; Carbon Tetrachloride; Liver; Male; Mice; Mice, Transgenic; Oxidative Stress; Polyamines; Putrescine; Spermidine; Spermine; Thioacetamide; Transgenes; Tumor Suppressor Protein p53; Up-Regulation | 2011 |
In hepatic fibrosis, liver sinusoidal endothelial cells acquire enhanced immunogenicity.
Topics: Animals; Antigens; Carbon Tetrachloride; Cell Proliferation; Chemokines; Cytokines; Dendritic Cells; Endothelial Cells; Flow Cytometry; Inflammation Mediators; Liver; Liver Cirrhosis; Lymphocyte Activation; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; T-Lymphocytes, Cytotoxic; T-Lymphocytes, Regulatory; Thioacetamide | 2010 |
Pigment epithelium-derived factor is an intrinsic antifibrosis factor targeting hepatic stellate cells.
Topics: Animals; Apoptosis; Blotting, Western; Carbon Tetrachloride; Cell Proliferation; Cells, Cultured; Enzyme-Linked Immunosorbent Assay; Eye Proteins; Fluorescent Antibody Technique; Hepatic Stellate Cells; Humans; Immunoenzyme Techniques; Immunoprecipitation; Intrinsic Factor; Liver; Liver Cirrhosis; Mice; Mice, Inbred BALB C; Nerve Growth Factors; NF-kappa B; PPAR gamma; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; RNA, Small Interfering; Serpins; Signal Transduction; Thioacetamide | 2010 |
Snail1 transcription factor is a critical mediator of hepatic stellate cell activation following hepatic injury.
Topics: Acute Disease; Adult; Aged; Animals; Blotting, Western; Carbon Tetrachloride; Cell Transdifferentiation; Cells, Cultured; Chronic Disease; Gene Silencing; Hepatic Stellate Cells; Humans; Immunologic Techniques; Liver; Liver Cirrhosis; Mice; Middle Aged; Reverse Transcriptase Polymerase Chain Reaction; Snail Family Transcription Factors; Thioacetamide; Transcription Factors; Up-Regulation; Wound Healing | 2011 |
Gas6 deficiency prevents liver inflammation, steatohepatitis, and fibrosis in mice.
Topics: Animals; Axl Receptor Tyrosine Kinase; Carbon Tetrachloride; Cell Proliferation; Choline Deficiency; Disease Progression; Ethionine; Fatty Liver; Gene Expression Regulation; Hepatitis; Inflammation Mediators; Intercellular Signaling Peptides and Proteins; Lipid Metabolism; Liver; Liver Cirrhosis, Experimental; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Myofibroblasts; Proto-Oncogene Proteins; Receptor Protein-Tyrosine Kinases; Stem Cells; Thioacetamide; Time Factors | 2011 |
Azelnidipine is a calcium blocker that attenuates liver fibrosis and may increase antioxidant defence.
Topics: Angiotensin II; Animals; Antioxidants; Azetidinecarboxylic Acid; Calcium; Calcium Channel Blockers; Carbon Tetrachloride; Cell Line; Cell Survival; Collagen Type I; Collagen Type I, alpha 1 Chain; Dihydropyridines; Disease Models, Animal; Gene Expression Regulation; Humans; Liver Cirrhosis; Male; Mice; Mice, Inbred C57BL; Reactive Oxygen Species; RNA, Messenger; Thioacetamide; Transforming Growth Factor beta1 | 2012 |
Liver fibrosis protects mice from acute hepatocellular injury.
Topics: Acute Disease; Animals; Apoptosis; bcl-2-Associated X Protein; bcl-Associated Death Protein; BH3 Interacting Domain Death Agonist Protein; Blotting, Western; Carbon Tetrachloride; Cells, Cultured; Chemical and Drug Induced Liver Injury; Collagen Type I; Cytoprotection; Enzyme Activation; fas Receptor; Liver; Liver Cirrhosis, Experimental; MAP Kinase Kinase 1; MAP Kinase Kinase 2; Mice; Mice, Inbred BALB C; Mice, Knockout; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Phosphorylation; Protein Kinase Inhibitors; Signal Transduction; Thioacetamide; Time Factors | 2012 |
Osteopontin, an oxidant stress sensitive cytokine, up-regulates collagen-I via integrin α(V)β(3) engagement and PI3K/pAkt/NFκB signaling.
Topics: Animals; Carbon Tetrachloride; Collagen Type I; Hepatic Stellate Cells; Humans; Integrin alphaVbeta3; Liver Cirrhosis; Male; Mice; Mice, Knockout; NF-kappa B; Osteopontin; Oxidative Stress; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Rats; Rats, Sprague-Dawley; Signal Transduction; Thioacetamide; Up-Regulation | 2012 |
Fibromodulin, an oxidative stress-sensitive proteoglycan, regulates the fibrogenic response to liver injury in mice.
Topics: Actins; Animals; Antioxidants; Carbon Tetrachloride; Case-Control Studies; Cell Movement; Cell Proliferation; Chemical and Drug Induced Liver Injury; Coculture Techniques; Collagen Type I; Endothelial Cells; Extracellular Matrix Proteins; Fibromodulin; Hep G2 Cells; Hepatic Stellate Cells; Hepatitis C; Hepatocytes; Humans; Liver; Liver Cirrhosis; Liver Cirrhosis, Biliary; Liver Cirrhosis, Experimental; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Oxidative Stress; Proteoglycans; Rats; RNA, Messenger; Thioacetamide; Time Factors; Transfection; Up-Regulation | 2012 |
Autophagy releases lipid that promotes fibrogenesis by activated hepatic stellate cells in mice and in human tissues.
Topics: Adenine; Adenosine Triphosphate; Animals; Autophagy; Autophagy-Related Protein 5; Autophagy-Related Protein 7; Carbon Tetrachloride; Cell Line; Energy Metabolism; Epoxy Compounds; Fibroblasts; Hepatic Stellate Cells; Humans; Idiopathic Pulmonary Fibrosis; Kidney; Lipid Metabolism; Liver; Liver Cirrhosis, Experimental; Lung; Mice; Mice, Inbred C57BL; Mice, Knockout; Microtubule-Associated Proteins; Oleic Acid; RNA Interference; Thioacetamide | 2012 |
1,4-Bis[2-(3,5-dichloropyridyloxy)]benzene induces substantial hyperplasia in fibrotic mouse liver.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Biomarkers; Bromodeoxyuridine; Carbon Tetrachloride; Cell Proliferation; Cyclin A; Cytochrome P450 Family 2; Disease Models, Animal; Gene Expression; Hepatocytes; Hyperplasia; Liver; Liver Cirrhosis; Liver Regeneration; Male; Mice; Mice, Inbred C57BL; Pyridines; Steroid Hydroxylases; Thioacetamide; Transforming Growth Factor beta | 2012 |
Heparin-binding epidermal growth factor-like growth factor suppresses experimental liver fibrosis in mice.
Topics: Actins; Animals; Carbon Tetrachloride; Collagen Type I; Collagen Type III; Connective Tissue Growth Factor; Heparin-binding EGF-like Growth Factor; Hepatic Stellate Cells; Humans; Intercellular Signaling Peptides and Proteins; Liver; Liver Cirrhosis; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Thioacetamide; Tissue Inhibitor of Metalloproteinase-1; Transforming Growth Factor beta1 | 2012 |
Reference genes for real-time PCR quantification of microRNAs and messenger RNAs in rat models of hepatotoxicity.
Topics: Acetaminophen; Actins; Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Galactosamine; Gene Expression; Gene Expression Profiling; Glyceraldehyde-3-Phosphate Dehydrogenases; Liver; MicroRNAs; Rats; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; RNA, Small Nuclear; Thioacetamide | 2012 |
Increased hepatic fibrosis and JNK2-dependent liver injury in mice exhibiting hepatocyte-specific deletion of cFLIP.
Topics: Animals; Apoptosis; Carbon Tetrachloride; CASP8 and FADD-Like Apoptosis Regulating Protein; Caspase 3; Caspase 9; Chemical and Drug Induced Liver Injury; Disease Models, Animal; Disease Progression; Enzyme Activation; Extracellular Signal-Regulated MAP Kinases; Genotype; Hepatocytes; Liver; Liver Cirrhosis; Male; Mice; Mice, Knockout; Mitogen-Activated Protein Kinase 9; Phenotype; Phosphorylation; Signal Transduction; Thioacetamide; Time Factors | 2012 |
Targeting androgen receptor in bone marrow mesenchymal stem cells leads to better transplantation therapy efficacy in liver cirrhosis.
Topics: Animals; Carbon Tetrachloride; Disease Models, Animal; ErbB Receptors; Female; Liver Cirrhosis; Male; Matrix Metalloproteinase 9; Mesenchymal Stem Cell Transplantation; Mice; Mice, Knockout; Phenotype; Receptors, Androgen; Receptors, Interleukin-1; RNA, Small Interfering; Signal Transduction; Thioacetamide; Treatment Outcome | 2013 |
Effect of N-acetyl cysteine (NAC), an organosulfur compound from Allium plants, on experimentally induced hepatic prefibrogenic events in Wistar rat.
Topics: Acetylcysteine; Allium; Animals; Carbon Tetrachloride; Disease Models, Animal; Liver Cirrhosis; Male; Oxidative Stress; Phytotherapy; Rats; Rats, Wistar; Sulfur; Thioacetamide | 2013 |
CHOP-mediated hepcidin suppression modulates hepatic iron load.
Topics: Animals; Carbon Tetrachloride; CCAAT-Enhancer-Binding Protein-alpha; Female; Gene Expression Regulation; Gene Knockout Techniques; Hepcidins; Humans; Iron; Iron Overload; Liver; Liver Cirrhosis, Experimental; Liver Diseases, Alcoholic; Mice; Mice, Inbred C57BL; Mice, Knockout; RNA, Messenger; Signal Transduction; Thioacetamide; Transcription Factor CHOP | 2013 |
Knockdown of N-acetylglucosaminyl transferase V ameliorates hepatotoxin-induced liver fibrosis in mice.
Topics: Actins; Alanine Transaminase; Animals; Carbon Tetrachloride; Cells, Cultured; Epithelial-Mesenchymal Transition; Glycosylation; Hepatocytes; Liver Cirrhosis; Male; Mice; Mice, Inbred ICR; Myofibroblasts; N-Acetylglucosaminyltransferases; Receptors, Transforming Growth Factor beta; Thioacetamide | 2013 |
Alteration of the microRNA-122 regulatory network in rat models of hepatotoxicity.
Topics: Animals; Carbon Tetrachloride; Cationic Amino Acid Transporter 1; CCAAT-Enhancer-Binding Protein-alpha; Chemical and Drug Induced Liver Injury; Cyclin D1; Cyclin G1; Cytochrome P-450 CYP2E1; Disease Models, Animal; Glutamate-Ammonia Ligase; Hepatocyte Nuclear Factor 4; Liver; Male; MicroRNAs; Proliferating Cell Nuclear Antigen; Rats; Rats, Wistar; RNA, Messenger; Thioacetamide; Transcription, Genetic | 2014 |
Angiotensin-II type 1 receptor-mediated Janus kinase 2 activation induces liver fibrosis.
Topics: Angiotensin II; Animals; Bile Ducts; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Disease Models, Animal; Hepatic Stellate Cells; Humans; Janus Kinase 2; Ligation; Liver Cirrhosis; Mice; Mice, Inbred C57BL; Mice, Knockout; Myofibroblasts; Phosphorylation; Rats; Rats, Sprague-Dawley; Receptor, Angiotensin, Type 1; Signal Transduction; Thioacetamide | 2014 |
Comparison of TGF-β, PDGF, and CTGF in hepatic fibrosis models using DMN, CCl4, and TAA.
Topics: Animals; Carbon Tetrachloride; Connective Tissue Growth Factor; Dimethylnitrosamine; Disease Models, Animal; Immunohistochemistry; Lipid Peroxidation; Liver Cirrhosis, Experimental; Male; Platelet-Derived Growth Factor; Rats; Rats, Sprague-Dawley; Thioacetamide; Transforming Growth Factor beta | 2016 |
The role of CYP2A5 in liver injury and fibrosis: chemical-specific difference.
Topics: Alanine Transaminase; Animals; Aryl Hydrocarbon Hydroxylases; Aspartate Aminotransferases; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Cytochrome P-450 CYP2E1; Cytochrome P450 Family 2; Disease Models, Animal; Glutathione; Liver; Liver Cirrhosis; Male; Mice, Inbred C57BL; Mice, Knockout; Thioacetamide; Thiobarbituric Acid Reactive Substances | 2016 |
Inhibition of SIRT2 suppresses hepatic fibrosis.
Topics: Adult; Aged; Animals; Carbon Tetrachloride; Case-Control Studies; Cell Line; Extracellular Signal-Regulated MAP Kinases; Female; Hepatic Stellate Cells; Humans; Liver Cirrhosis; Male; Mice; Mice, Inbred C57BL; Middle Aged; Proto-Oncogene Proteins c-myc; Sirtuin 2; Thioacetamide | 2016 |
Niemann-Pick Type C2 Protein Mediates Hepatic Stellate Cells Activation by Regulating Free Cholesterol Accumulation.
Topics: Animals; Blotting, Western; Carbon Tetrachloride; Carrier Proteins; Cholesterol; Disease Models, Animal; Glycoproteins; Hepatic Stellate Cells; Humans; Immunoenzyme Techniques; Liver Cirrhosis; Mice; Mice, Inbred C57BL; Real-Time Polymerase Chain Reaction; Thioacetamide; Transforming Growth Factor beta1; Vesicular Transport Proteins | 2016 |
MiR-29a Assists in Preventing the Activation of Human Stellate Cells and Promotes Recovery From Liver Fibrosis in Mice.
Topics: Animals; Carbon Tetrachloride; Cell Line; Cell Survival; Collagen; Collagen Type I; Collagen Type I, alpha 1 Chain; Disease Models, Animal; Gene Expression Regulation; Genetic Therapy; Hepatic Stellate Cells; Humans; Liver Cirrhosis; Lymphokines; Mice; MicroRNAs; Platelet-Derived Growth Factor; Thioacetamide | 2016 |
Automated evaluation of liver fibrosis in thioacetamide, carbon tetrachloride, and bile duct ligation rodent models using second-harmonic generation/two-photon excited fluorescence microscopy.
Topics: Animals; Automation, Laboratory; Bile Ducts; Carbon Tetrachloride; Disease Models, Animal; Hydroxyproline; Ligation; Liver; Liver Cirrhosis; Male; Mice, Inbred BALB C; Mice, Inbred C57BL; Microscopy, Fluorescence, Multiphoton; Rats, Sprague-Dawley; Rats, Wistar; Reproducibility of Results; Sensitivity and Specificity; Species Specificity; Thioacetamide | 2017 |
Milk Fat Globule-EGF Factor 8, Secreted by Mesenchymal Stem Cells, Protects Against Liver Fibrosis in Mice.
Topics: Animals; Antigens, Surface; Carbon Tetrachloride; Cell Line; Collagen; Extracellular Matrix; Hepatic Stellate Cells; Hepatocytes; Humans; Integrin alphaVbeta3; Liver Cirrhosis; Male; Mesenchymal Stem Cells; Metabolome; Metalloproteases; Mice; Milk Proteins; Receptors, Transforming Growth Factor beta; Smad2 Protein; Thioacetamide; Transforming Growth Factor beta1 | 2017 |
Optimized Mouse Models for Liver Fibrosis.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP-Binding Cassette Sub-Family B Member 4; Azo Compounds; Biomarkers; Carbon Tetrachloride; Collagen; Disease Models, Animal; Disease Progression; Extracellular Matrix; Gene Expression; Histocytochemistry; Humans; Hydroxyproline; Liver; Liver Cirrhosis; Mice; Mice, Inbred C57BL; Mice, Knockout; Thioacetamide | 2017 |
Ductular reaction correlates with fibrogenesis but does not contribute to liver regeneration in experimental fibrosis models.
Topics: Animals; Carbon Tetrachloride; Cell Proliferation; Disease Models, Animal; Erlotinib Hydrochloride; Fibrosis; Imatinib Mesylate; Keratin-19; Liver; Liver Cirrhosis; Liver Regeneration; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Microscopy, Confocal; Protein Kinase Inhibitors; Thioacetamide; Transforming Growth Factor beta | 2017 |
4 in 1: Antibody-free protocol for isolating the main hepatic cells from healthy and cirrhotic single rat livers.
Topics: Albumins; Animals; Capillaries; Carbon Tetrachloride; Cell Separation; Cell Survival; Centrifugation; Endothelial Cells; Hepatic Stellate Cells; Hepatocytes; Lipopolysaccharides; Liver; Liver Cirrhosis; Macrophages; Rats; Rats, Wistar; Thioacetamide; Urea | 2019 |
The histone demethylase KDM4D promotes hepatic fibrogenesis by modulating Toll-like receptor 4 signaling pathway.
Topics: Animals; Carbon Tetrachloride; Cell Line; Epigenesis, Genetic; Gene Regulatory Networks; Hepatic Stellate Cells; Histones; Humans; Jumonji Domain-Containing Histone Demethylases; Liver Cirrhosis; Male; Mice; Rats; Signal Transduction; Thioacetamide; Toll-Like Receptor 4; Transcription, Genetic; Up-Regulation | 2019 |
Hepcidin-orchestrated Hemogram and Iron Homeostatic Patterns in Two Models of Subchronic Hepatic injury.
Topics: Animals; Blood Chemical Analysis; Carbon Tetrachloride; Hepcidins; Injections, Intraperitoneal; Interleukin-6; Iron; Leukocytosis; Liver Cirrhosis; Male; Rats; Thioacetamide; Thrombocytopenia; Transferrin | 2019 |
Co-expression network analysis of lncRNAs and mRNAs in rat liver tissue reveals the complex interactions in response to pathogenic cytotoxicity.
Topics: Animals; Carbon Tetrachloride; Chloroform; Liver; Rats; RNA, Long Noncoding; RNA, Messenger; Thioacetamide; Transcriptome | 2019 |
Ketogenic Diet Enhances the Cholesterol Accumulation in Liver and Augments the Severity of CCl
Topics: 3-Hydroxybutyric Acid; Acetoacetates; Actins; Animals; Becaplermin; Carbon Tetrachloride; Catalase; Cell Proliferation; Cholesterol; Collagen Type I; Cytochrome P-450 CYP1A2; Desmin; Diet, Ketogenic; Disease Progression; Gene Expression Regulation; Hepatic Stellate Cells; Liver; Liver Cirrhosis; Male; Mice; Mice, Inbred C57BL; Primary Cell Culture; Severity of Illness Index; Superoxide Dismutase; Superoxide Dismutase-1; Thioacetamide; Transforming Growth Factor beta | 2021 |
Mouse Models of Liver Fibrosis.
Topics: Animals; Carbon Tetrachloride; Diet, High-Fat; Disease Models, Animal; Hepatic Stellate Cells; Humans; Liver Cirrhosis; Mice; Mice, Inbred BALB C; Pyridines; Thioacetamide | 2021 |
Auranofin prevents liver fibrosis by system Xc-mediated inhibition of NLRP3 inflammasome.
Topics: Amino Acid Transport System y+; Animals; Apoptosis; Auranofin; Carbon Tetrachloride; Cells, Cultured; Humans; Inflammasomes; Interleukin-1beta; Kupffer Cells; Liver; Liver Cirrhosis; Macrophages; Male; Mice, Inbred BALB C; Mice, Inbred C57BL; NLR Family, Pyrin Domain-Containing 3 Protein; Pyroptosis; Thioacetamide | 2021 |
Impact of lifestyle interventions targeting physical exercise and caloric intake on cirrhosis regression in rats.
Topics: Animals; Caloric Restriction; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Energy Intake; Exercise Therapy; Healthy Lifestyle; Hypertension, Portal; Liver; Liver Cirrhosis, Experimental; Male; Physical Endurance; Rats, Wistar; Risk Reduction Behavior; Thioacetamide; Time Factors | 2021 |
Dietary oxidized frying oil activates hepatic stellate cells and accelerates the severity of carbon tetrachloride- and thioacetamide-induced liver fibrosis in mice.
Topics: Animals; Carbon Tetrachloride; Dietary Fats, Unsaturated; Hepatic Stellate Cells; Liver; Liver Cirrhosis; Matrix Metalloproteinase 2; Mice; Thioacetamide; Transforming Growth Factor beta1 | 2023 |