carbon tetrachloride has been researched along with hydroxyproline in 138 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 15 (10.87) | 18.7374 |
| 1990's | 14 (10.14) | 18.2507 |
| 2000's | 54 (39.13) | 29.6817 |
| 2010's | 52 (37.68) | 24.3611 |
| 2020's | 3 (2.17) | 2.80 |
| Authors | Studies |
|---|---|
| Kawasaki, H; Murawaki, Y; Yamamoto, H | 1 |
| Kubo, K; Mori, T; Ohishi, E; Sano, J; Yoshitake, I | 1 |
| Fujiwara, K; Mochida, S; Ogata, I; Tomiya, T | 1 |
| Kato, M; Moriwaki, H; Muto, Y; Noma, A; Nozaki, Y; Okuno, M; Suzuki, Y; Tagaya, O | 1 |
| Jeney, A; Lapis, K; Szende, B | 1 |
| Musil, J; Nováková, O | 1 |
| Cerbón, J; Cerbón-Ambriz, J; González, E; Rojkind, M | 1 |
| Hatahara, T; Hori, H; Igarashi, S; Katoh, M; Nagai, Y; Sakai, A; Sakakibara, K; Sugimoto, T | 1 |
| Ala-Kokko, L; Pääkkö, P; Ryhänen, L | 1 |
| de Nie, I; van Gool, J; van Vugt, H | 1 |
| Sudoh, A; Takechi, M; Toshida, K; Umezu, K; Yuasa, S | 1 |
| Becker, K | 1 |
| Bremmelgaard, A; Dupont, B; Jorgensen, M; Keiding, S; Ranek, L; Thomsen, P; Tyrsted, G | 1 |
| Wick, G | 1 |
| Adam, M; Musil, J; Weissová, J | 1 |
| Scheel, G; Siegers, CP; Völpel, M; Younes, M | 1 |
| Mowat, AP; Trivedi, P | 1 |
| Katoh, M; Sugimoto, T | 1 |
| Aisen, AM; Doi, K; Swanson, SD | 1 |
| Marumo, F; Sato, C; Tanaka, Y; Yamane, M | 1 |
| Bosma, A; Brouwer, A; Hendriks, HF; Knook, DL; Roholl, PJ; Seifert, WF; Seifert-Bock, I; van Leeuwen, RE; van Thiel-de Ruiter, GC | 1 |
| Ala-Kokko, L; Anttila, S; Ferrans, VJ; Pääkkö, P; Peura, R; Ryhänen, L; Sormunen, R | 1 |
| Asakura, H; Ichida, T; Komoriya, Y; Matsuda, Y; Matsumoto, K; Nakamura, T; Nishiyama, E; Yamada, A | 1 |
| Fujise, N; Higashio, K; Masunaga, H; Ogawa, H; Shiota, A; Yamashita, Y; Yasuda, H | 1 |
| Arthur, MJ; Benyon, RC; Hovell, C; Iredale, JP; McCullen, M; Northrop, M; Pawley, S; Pickering, J | 1 |
| Fujita, Y; Nakata, Y; Sugihara, A; Terada, N; Tsujimura, T | 1 |
| Cabré, M; Camps, J; del Castillo, D; Ferré, N; Folch, J; Hernàndez, M; Joven, J; Paternain, JL | 1 |
| Jeon, CH; Kim, J; Ko, G; Park, EJ; Sohn, DH | 1 |
| Choi, JH; Kang, HC; Kim, JY; Kim, SJ; Kim, YC; Lee, BH; Lee, JH; Lee, SJ; Nan, JX; Park, EJ; Sohn, DH | 1 |
| Castilla-Cortázar, I; García, M; Muguerza, B; Prieto, J; Quiroga, J; Santidrián, S | 1 |
| Cai, WM; Liu, RH; Weng, HL | 1 |
| Kim, YC; Ko, G; Nan, JX; Park, EJ; Sohn, DH | 1 |
| Anselmi, K; Gandhi, CR; Nemoto, E; Subbotin, VM | 1 |
| Akyol, G; Dinçer, S; Oz, E; Ozenirler, S; Ozoğul, C | 1 |
| Armendariz-Borunda, J; Garcia, J; García, L; Grijalva, G; Hernández, I; Margolin, S; Muriel, P; Salazar, A; Sandoval, A; Vera, J | 1 |
| Cheng, M; Huang, N; Li, C; Li, L; Liu, J; Luo, J; Waalkes, MP | 1 |
| Chayama, K; Kanno, K; Tazuma, S | 1 |
| BOTTIGLIONI, E; ORLANDI, G; STURANI, PL | 1 |
| DELAHUERGA, J; KENT, G; MINICK, OT; ORFEI, E; VOLINI, FI | 1 |
| Enjoji, M; Fukushima, M; Kobayashi, N; Kohjima, M; Kotoh, K; Morizono, S; Nakamuta, M; Nawata, H | 1 |
| Bouscarel, B; Doy, M; Ikegami, T; Karube, M; Matsuzaki, Y; Miyazaki, T; Tanaka, N | 1 |
| Gui, SY; Sun, WY; Wang, H; Wang, NP; Wei, W; Wu, L; Xu, SY | 1 |
| Du, GL; Hu, YY; Liu, CH; Liu, P; Liu, Y; Mu, YP; Xu, LM | 1 |
| Andrade, ZA; Baptista, AP; Barbosa, AA; Di Vinicius, I | 1 |
| Chidambaranathan, N; Christina, AJ; Kothai, R; Nalini, G; Robert, SJ; Saraswathy, GR; Therasal, RL | 1 |
| Tang, H; Wang, LC; Zhao, LS | 1 |
| Du, G; Hu, YY; Liu, P; Liu, Y; Mu, Y; Wang, L; Xu, L | 1 |
| Inoue, K; Kodai, S; Minamiyama, Y; Mizuguchi, S; Okada, S; Suehiro, S; Takemura, S; Tsukioka, T | 1 |
| Fang, HL; Kuo, SC; Lin, WC; Lin, WL; Wang, BC | 1 |
| Liu, P; Long, AH; Mu, YP | 1 |
| Chayama, K; Horiuchi, M; Hyogo, H; Iwai, M; Kanno, K; Nabeshima, Y; Tazuma, S | 1 |
| An, P; Liu, SQ; Luo, HS; Lv, P; Paul, SC; Xiao, YJ | 1 |
| Chan, WT; Li, M; Szeto, KY; Wong, J; Yau, YF; Zhang, HQ | 1 |
| Gong, ZJ; Huang, TX; Huang, YQ; Song, SL; Zhang, QR | 1 |
| Liao, ZX; Wang, H; Wu, Y; Xu, D | 1 |
| Li, C; Liu, L; Tang, H; Wang, L; Yao, F; Zhang, H; Zhao, L | 1 |
| Awada, M; Bautista, A; Gardner, JL; Hellerstein, MK; Lindwall, G; Turner, SM | 1 |
| Cao, BQ; Chen, R; Huang, SB; Lin, JZ; Lin, N; Tang, ZF; Xiang, P; Xu, RY; Zhong, YS | 1 |
| Fang, HL; Lai, JJ; Lin, WC; Lin, WL | 1 |
| Gui, SY; Sun, WY; Wang, H; Wei, W; Wu, L | 1 |
| Chen, W; Qiu, JF; Wu, ZY; Zhang, ZQ | 1 |
| Chan, MC; Fang, HL; Lin, HY; Lin, WC; Lin, WL | 1 |
| Abarca-Quinones, J; Annet, L; Leclercq, I; Peeters, F; Salameh, N; Sinkus, R; Ter Beek, LC; Van Beers, BE | 1 |
| Abdallah, HM; El-Batran, SA; El-Demerdash, E; Salam, OM; Shaffie, NM | 1 |
| Kong, XW; Sun, Y; Wu, LM; Wu, XX; Xu, Q; Zhang, YH | 1 |
| Chen, LB; Guo, Y; Ping, J; Wang, H; Xu, D; Zhang, BJ | 1 |
| Fang, HL; Lin, WC | 2 |
| Anstee, QM; Cox, R; Goldin, RD; Martinelli, A; Thursz, MR; Wright, M | 1 |
| Aoyagi, Y; Fukunaga, K; Hashimoto, I; Ikeda, O; Matsuo, R; Murata, S; Nakano, Y; Ohkohchi, N; Watanabe, M; Yasue, H | 1 |
| Li, XM; Wang, BE; Wang, TL; Zhao, XY | 1 |
| Fernández-Martínez, E; Galicia-Moreno, M; Moreno, MG; Muriel, P; Pérez-Alvarez, VM; Reyes-Gordillo, K; Rodríguez-Rivera, A; Segovia, J; Shibayama, M; Tsutsumi, V; Vergara, P | 1 |
| Bo, H; Chen, FH; Chen, ZW; Li, F; Ling, L; Xia, LJ; Yuan, LP; Zhong, MM | 1 |
| Fang, HL; Lai, JT; Lin, WC | 1 |
| Du, G; Du, J; Li, F; Liu, P; Long, A; Mu, Y; Wang, G; Wang, L | 1 |
| Adamska, T; Bylka, W; Ewertowska, M; Jodynis-Liebert, J; Matławska, I | 1 |
| Cheon, HJ; Kim, SH; Lee, SM; Oh, ST; Shim, KS; Shin, E; Yun, N | 1 |
| Fang, HL; Hsieh, WT; Lai, JT; Lin, WC | 1 |
| Hong, RT; Mei, Q; Xu, JM | 1 |
| Bennett, RG; Heimann, DG; Tuma, DJ | 1 |
| Chen, XL; Deng, ZY; Jin, Y; Li, J; Lü, XW | 1 |
| Hu, MH; Wu, XM; Wu, YH; Zhang, XM; Zhao, Y | 1 |
| Dong, MX; Geng, YT; Jia, Y; Li, CC; Li, XY; Liu, JC; Niu, YC; Zhang, YB; Zhou, L | 1 |
| Che, QM; Pu, XP; Sun, H; Zhao, X | 1 |
| Chang, CC; Chao, JC; Tam, KW; Tsai, YH; Wu, SJ | 1 |
| Fang, BW; Lou, JS; Yang, FR | 2 |
| Firdous, AP; Kuttan, R; Preethi, KC; Sindhu, ER | 1 |
| Hsu, CC; Hsu, CL; Yen, GC | 1 |
| Chen, W; Luo, M; Sun, YW; Wang, Z; Wu, ZY; Xu, JP; Zheng, YC | 1 |
| Jia, J; Wang, H; Wang, T; You, H; Zhang, Y | 1 |
| Hultcrantz, R; Kinnman, N; Rosenberg, P; Sjöström, M; Söderberg, C; Stål, P | 1 |
| Li, X; Tian, XP; Yin, YY | 1 |
| Jiang, H; Li, HL; Li, P; Lu, GC; Wang, T; Yuan, BJ; Zhang, WD; Zhao, LJ | 1 |
| Fischer, HP; Hall, R; Hochrath, K; Huss, S; Lammert, F; Pieper-Fürst, U; Tacke, F; Weiskirchen, R | 1 |
| Dong, X; Jiang, H; Jiang, X; Kang, K; Kanwar, JR; Li, J; Pan, S; Qiao, H; Sun, X; Tan, G; Zhao, M | 1 |
| Bao, YY; Gu, Y; Huo, HZ; Liang, YK; Wang, B | 1 |
| Knight, V; Lourensz, D; Sievert, W; Tchongue, J; Tipping, P | 1 |
| Kang, JW; Lee, SM; Sung, YK; Yoon, SJ | 1 |
| Choi, MK; Hwang, SY; Shin, JW; Son, CG; Wang, JH | 1 |
| Chen, Q; Cheng, YY; Deng, L; Ding, D; Li, QQ; Liu, XP; Mei, S; Ou-Yang, Q; Tao, LL; Xu, JW; Xu, ZD; Yu, J | 1 |
| Fu, C; Liu, B; Qian, H; Wang, Y; Yu, J; Zhao, Y | 1 |
| Alford, JK; Caravan, P; Fuchs, BC; Guimaraes, AR; Lauwers, GY; Loving, GS; Polasek, M; Schühle, DT; Tanabe, KK; Uppal, R; Wei, L; Yamada, S | 1 |
| Chen, MF; Cheng, JT; Chung, HH; Tzeng, JI | 1 |
| He, M; Huang, Q; Huang, R; Li, L; Li, Y; Liao, M; Lin, X; Wei, L; Zhang, S; Zheng, L; Zhuo, L | 1 |
| Liu, C; Liu, P; Peng, Y; Ren, H; Tao, Y; Wang, Z; Yu, H; Zhao, Z; Zhu, B | 1 |
| Chang, HM; Chien, CT; Hung, GD; Lee, HS; Lee, KL; Li, PC | 1 |
| Duan, X; Guo, C; He, Q; Li, R; Liang, T; Xu, L | 1 |
| Collins, BH; Holzknecht, ZE; Liu, S; Lynn, KA; Parker, W; Rockey, DC; Sempowski, GD; Smith, CC | 1 |
| Dong, W; Lv, B; Wei, F; Yang, L | 1 |
| He, Y; Huang, S; Liu, W; Wu, F; Zhang, Y; Zhu, N | 1 |
| Fukunaga, K; Murata, S; Ohkohchi, N; Takahashi, K | 1 |
| Chen, X; Chen, Y; Hou, Y; Shi, C; Ying, X; Zhang, W; Zhang, Y | 1 |
| El-kashef, HA; Ibrahim, TM; Shaaban, AA; Shaker, ME; Zalata, KR | 1 |
| Diao, Y; Huang, X; Lin, J; Lv, Y; Wang, X; Xu, L | 1 |
| Heeba, GH; Mahmoud, ME | 1 |
| Chen, YH; Cheng, PJ; Cheng, WT; Chou, CJ; Kao, YJ; Ko, IC; Peng, SY; Shaw, SW; Wu, SC | 1 |
| Chen, J; He, W; Huang, X; Wang, B; Wang, L; Yang, J; Zhuang, Y | 1 |
| Liu, CH; Liu, ZL; Shen, L; Tao, YY; Yan, XC; Zhou, T | 1 |
| Burkly, LC; Choi, SS; Diehl, AM; Guy, CD; Karaca, G; Krüger, L; Machado, MV; Michelotti, GA; Moylan, C; Swiderska-Syn, M; Xie, G | 1 |
| Dong, L; Gao, TJ; Li, XM; Shi, HT | 1 |
| Dang, S; Jia, X; Li, Y; Wang, W; Wang, X; Wang, Y; Zhai, S | 1 |
| Bettaieb, A; Chiamvimonvat, N; Dong, H; Haj, FG; Hammock, BD; Harris, TR; Kodani, S; Myers, R | 1 |
| Dong, D; Peng, J; Qi, Y; Xu, L; Yin, L | 1 |
| Chen, B; Chen, J; He, W; Qi, L; Shao, D; Wang, L; Wang, M; Zhuang, Y | 1 |
| Chen, JM; Du, GL; Fu, WW; Hu, YY; Liu, CH; Liu, P; Mu, YP; Ning, BB; Sun, MY; Xu, LM; Zhang, H; Zhou, YN | 1 |
| Bak, J; Cheong, KO; Chung, HY; Je, NK; Kim, KW; Lee, C; Moon, JO; Shin, DS; Yoon, S | 1 |
| Feng, SX; Tian, LP; Tian, X; Wang, JH; Xue, L; Zhan, YY | 1 |
| Chen, L; Liu, F; Liu, FF; Lu, YQ; Rao, HY; Ren, YY; Teng, X; Wei, L; Wu, N; Zhang, W | 1 |
| Kim, YO; Popov, Y; Schuppan, D | 1 |
| Hosseini, A; Kashani, IR; Khanlarkhani, N; Majidpoor, J; Mortezaee, K; Nekoonam, S; Pasbakhsh, P; Sabbaghziarani, F; Zendedel, A | 1 |
| Cao, W; Li, H; Wang, F; Wang, SW; Zhang, T; Zhang, Y; Zhao, H | 1 |
| Alshammari, GM; Balakrishnan, A; Chinnasamy, T | 1 |
| Abdelghany, RH; El-Ahwany, E; Helal, NS; Mahmoud, AAA; Saber, S | 1 |
| Jiang, H; Ma, J; Qiu, Y; Wang, M; Zhang, M; Zhao, X | 1 |
| Dong, P; Fan, S; Geng, W; Li, C; Xiao, Q; Zhao, B; Zheng, J; Zhou, G | 1 |
| Bai, L; Chen, YL; Duan, SZ; Li, HX; Liu, Y; Song, ZC; Wang, YL; Zhu, SW | 1 |
| Imafuku, T; Maeda, H; Maruyama, T; Minayoshi, Y; Nakano, T; Nishida, K; Takano, M; Toda, S; Watanabe, H | 1 |
1 trial(s) available for carbon tetrachloride and hydroxyproline
| Article | Year |
|---|---|
Animal experiment and clinical study of effect of gamma-interferon on hepatic fibrosis.
Topics: Animals; Antineoplastic Agents; Biopsy; Carbon Tetrachloride; Dimethylnitrosamine; Disease Models, Animal; Female; Hepatitis B, Chronic; Humans; Hyaluronic Acid; Hydroxyproline; Interferon-gamma; Liver; Liver Cirrhosis; Liver Function Tests; Male; Rats; Rats, Sprague-Dawley; Recombinant Proteins | 2001 |
137 other study(ies) available for carbon tetrachloride and hydroxyproline
| Article | Year |
|---|---|
Collagenolytic cathepsin B and L activity in experimental fibrotic liver and human liver.
Topics: Animals; Carbon Tetrachloride; Cathepsin B; Cathepsin H; Cathepsin L; Cathepsins; Collagen; Cysteine Endopeptidases; Endopeptidases; Humans; Hydroxyproline; Liver; Liver Cirrhosis, Experimental; Male; Rats; Rats, Inbred Strains | 1992 |
Effects of KF-14363 on liver fibrosis in rats with chronic liver injury induced by carbon tetrachloride.
Topics: Alkaline Phosphatase; Animals; Benzazepines; Carbon Tetrachloride; Chronic Disease; Hydroxyproline; Liver Cirrhosis, Experimental; Male; Rats; Rats, Inbred Strains; Thiazoles; Transaminases | 1991 |
Minor contribution of hepatocytes to collagen production in normal and early fibrotic rat livers.
Topics: Amino Acids; Animals; Carbon Tetrachloride; Collagen; Dimethylnitrosamine; Hydroxyproline; Liver; Liver Cirrhosis, Experimental; Male; Protein Biosynthesis; Rats; Rats, Inbred F344; Reference Values; Serum Albumin; Time Factors | 1991 |
Inhibitory effect of acyclic retinoid (polyprenoic acid) on hepatic fibrosis in CCl4-treated rats.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Carbon Tetrachloride; Collagen; Hydroxyproline; Liver Cirrhosis, Experimental; Liver Function Tests; Male; Procollagen-Proline Dioxygenase; Rats; Rats, Inbred Strains; Tretinoin | 1990 |
Methylcellulose prevents the regression of carbon tetrachloride-induced liver fibrosis and cirrhosis in rats.
Topics: Animals; Carbon Tetrachloride; Collagen; Hydroxyproline; Liver; Liver Cirrhosis, Experimental; Male; Methylcellulose; Organ Size; Rats; Rats, Inbred F344; Weight Gain | 1990 |
The course of healing of the inflammatory granuloma in rats after the application of tetrachlormethane and 6-azauridine.
Topics: Animals; Azauridine; Carbon Tetrachloride; Glycoproteins; Granuloma; Hydroxyproline; Inflammation; Liver; Liver Regeneration; Male; N-Acetylneuraminic Acid; Rats; Rats, Inbred Strains; Sialic Acids; Uronic Acids | 1985 |
Lactate and pyruvate increase the incorporation of [3H]proline into collagen [3H]hydroxyproline in liver slices of CCl4 cirrhotic rats.
Topics: Animals; Carbon Tetrachloride; Collagen; Cyclic AMP; Hydroxyproline; Lactates; Lactic Acid; Liver; Liver Cirrhosis, Experimental; Male; Proline; Pyruvates; Pyruvic Acid; Rats; Rats, Inbred Strains | 1987 |
Anti-fibrotic effect of malotilate on liver fibrosis induced by carbon tetrachloride in rats.
Topics: Animals; Carbon Tetrachloride; Collagen; Hydroxyproline; Liver Cirrhosis, Experimental; Male; Malonates; Microbial Collagenase; Procollagen-Proline Dioxygenase; Rats; Rats, Inbred Strains | 1986 |
A light microscopic and biochemical study of carbon tetrachloride-induced pulmonary fibrosis in rats: the preventive effect of malotilate.
Topics: Animals; Carbon Tetrachloride; Collagen; Female; Fibroblasts; Hydroxyproline; Malonates; Pulmonary Fibrosis; Rats; Rats, Inbred Strains | 1987 |
Acute phase reactants enhance CCl4 induced liver cirrhosis in the rat.
Topics: Alanine Transaminase; Animals; C-Reactive Protein; Carbon Tetrachloride; Drug Synergism; Glutamate Dehydrogenase; Hexosamines; Humans; Hydroxyproline; L-Iditol 2-Dehydrogenase; Liver; Liver Cirrhosis, Experimental; Male; Rats; Rats, Inbred Strains; Triglycerides | 1986 |
[Therapeutic effect of TRQ on chronic liver injury model in rats induced by CCl4].
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Body Weight; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Chronic Disease; Histamine; Hydroxyproline; Isoquinolines; Liver; Liver Diseases; Male; Rats; Rats, Inbred Strains | 1985 |
[The influence of cortisone on proliferation and metabolism of the connective tissue in the experimental cirrhosis of the liver].
Topics: Acetates; Amides; Animals; Carbon Tetrachloride; Connective Tissue; Glucosamine; Glycosaminoglycans; Hexosamines; Hydroxyproline; Injections, Intraperitoneal; Liver Cirrhosis, Experimental; Prednisolone; Rats; Sulfates; Sulfur Isotopes | 1969 |
The effects of azathioprine on CCl4 induced cirrhosis in the rat.
Topics: Adenosine Triphosphate; Animals; Azathioprine; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Disease Models, Animal; DNA; Female; Hydroxyproline; Liver; Liver Cirrhosis; Liver Cirrhosis, Experimental; Organ Size; Proteins; Rats; RNA; Triglycerides | 1974 |
[The inhibition of carbon tetrachloride induced liver fibrosis in rats with aminoacetonitrile].
Topics: Acetates; Amines; Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Collagen; Connective Tissue; Female; Hydroxyproline; Liver; Liver Diseases; Mesoderm; Nitriles; Rats | 1967 |
[Effect of the toxic damage to the liver by carbon tetrachloride on the content of collagen in granulation tissue of rats].
Topics: Animals; Carbon Isotopes; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Collagen; Granulation Tissue; Hydroxyproline; Male; Proline; Radiometry; Rats | 1968 |
Effects of dithiocarb and (+)-catechin against carbon tetrachloride-alcohol-induced liver fibrosis.
Topics: Animals; Benzopyrans; Carbon Tetrachloride; Catechin; Collagen; Ditiocarb; Ethanol; Hydroxyproline; Liver; Male; Rats; Rats, Inbred Strains; Thiocarbamates | 1982 |
Carbon tetrachloride-induced hepatic fibrosis and cirrhosis in the developing rat: an experimental model of cirrhosis in childhood.
Topics: Alanine Transaminase; Alkaline Phosphatase; Animals; Aspartate Aminotransferases; Carbon Tetrachloride; Collagen; Disease Models, Animal; Hydroxyproline; Liver; Liver Cirrhosis, Experimental; Male; Phenobarbital; Procollagen-Proline Dioxygenase; Rats; Rats, Inbred Strains; Time Factors | 1983 |
[Effect of malotilate (diisopropyl 1, 3-dithiol-2-ylidenemalonate) on chronic liver injury caused by carbon tetrachloride].
Topics: Animals; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Hydroxyproline; Liver; Liver Cirrhosis, Experimental; Male; Malonates; Malondialdehyde; Microsomes, Liver; Phospholipids; Proteins; Rats; Transaminases; Triglycerides | 1982 |
Detection of liver fibrosis with magnetic cross-relaxation.
Topics: Animals; Body Water; Carbon Tetrachloride; Hydroxyproline; Image Enhancement; Liver; Liver Cirrhosis, Experimental; Magnetic Resonance Imaging; Magnetics; Organ Size; Phenobarbital; Protons; Rats; Rats, Sprague-Dawley | 1994 |
Role of hepatic vitamin A and lipocyte distribution in experimental hepatic fibrosis.
Topics: Animals; Carbon Tetrachloride; Collagen; Diterpenes; Hydroxyproline; Liver; Liver Cirrhosis, Experimental; Male; Rats; Rats, Sprague-Dawley; Retinyl Esters; Vitamin A | 1993 |
Vitamin A deficiency potentiates carbon tetrachloride-induced liver fibrosis in rats.
Topics: Animals; Carbon Tetrachloride; Collagen; Female; Hydroxyproline; Liver; Liver Cirrhosis, Experimental; Rats; Rats, Inbred Strains; Retinoids; Specific Pathogen-Free Organisms; Vitamin A; Vitamin A Deficiency | 1994 |
Biochemical and morphological characterization of carbon tetrachloride-induced lung fibrosis in rats.
Topics: Animals; Carbon Tetrachloride; Convalescence; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; gamma-Glutamyltransferase; Hydroxyproline; Lung; Pulmonary Fibrosis; Rats; Rats, Sprague-Dawley | 1996 |
Preventive and therapeutic effects in rats of hepatocyte growth factor infusion on liver fibrosis/cirrhosis.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Body Weight; Carbon Tetrachloride; Dimethylnitrosamine; Fibrinogen; Hepatocyte Growth Factor; Humans; Hydroxyproline; Liver; Liver Cirrhosis, Experimental; Male; Organ Size; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Serum Albumin; Survival Rate | 1997 |
Effects of the deleted form of hepatocyte growth factor on serum hyaluronate levels in rats with liver cirrhosis.
Topics: Animals; Carbon Tetrachloride; Dimethylnitrosamine; Hepatocyte Growth Factor; Humans; Hyaluronic Acid; Hydroxyproline; Liver; Liver Cirrhosis, Experimental; Liver Function Tests; Male; Organ Size; Prothrombin Time; Rats; Rats, Wistar; Recombinant Proteins; Sequence Deletion | 1998 |
Mechanisms of spontaneous resolution of rat liver fibrosis. Hepatic stellate cell apoptosis and reduced hepatic expression of metalloproteinase inhibitors.
Topics: Animals; Apoptosis; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Collagenases; Gene Expression Regulation; Hydroxyproline; Liver Cirrhosis, Experimental; Male; Matrix Metalloproteinase 1; Matrix Metalloproteinase 13; Matrix Metalloproteinase Inhibitors; Procollagen; Rats; Rats, Sprague-Dawley; Remission, Spontaneous; RNA, Messenger; Tissue Inhibitor of Metalloproteinase-1; Tissue Inhibitor of Metalloproteinase-2 | 1998 |
Evaluation of role of mast cells in the development of liver fibrosis using mast cell-deficient rats and mice.
Topics: Animals; Bile Ducts; Blood; Carbon Tetrachloride; Collagen; Hydroxyproline; Liver; Liver Cirrhosis, Experimental; Mast Cells; Mice; Mice, Mutant Strains; Rats; Rats, Mutant Strains; Swine | 1999 |
Inhibition of hepatic cell nuclear DNA fragmentation by zinc in carbon tetrachloride-treated rats.
Topics: Animals; Carbon Tetrachloride; DNA Fragmentation; Hydroxyproline; Liver; Liver Cirrhosis, Experimental; Male; Metallothionein; Rats; Rats, Wistar; Zinc | 1999 |
Protective effect of curcumin in rat liver injury induced by carbon tetrachloride.
Topics: Alanine Transaminase; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspartate Aminotransferases; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Curcumin; Dose-Response Relationship, Drug; Hydroxyproline; Liver; Liver Diseases; Male; Malondialdehyde; Rats; Rats, Sprague-Dawley | 2000 |
The ethanol-soluble part of a hot-water extract from Artemisia iwayomogi inhibits liver fibrosis induced by carbon tetrachloride in rats.
Topics: Animals; Artemisia; Carbon Tetrachloride; Disease Models, Animal; Ethanol; Hot Temperature; Hydroxyproline; Liver Cirrhosis; Male; Malondialdehyde; Plant Extracts; Plants, Medicinal; Rats; Rats, Sprague-Dawley; Water | 2000 |
Antifibrogenic effect in vivo of low doses of insulin-like growth factor-I in cirrhotic rats.
Topics: Actins; Animals; Carbon Tetrachloride; Collagen; Disease Models, Animal; Dose-Response Relationship, Drug; Fibrosis; Hydroxyproline; Immunohistochemistry; Insulin-Like Growth Factor I; Lipid Peroxidation; Liver; Liver Cirrhosis; Male; Malondialdehyde; Procollagen-Proline Dioxygenase; Rats; Rats, Wistar; RNA, Messenger | 2001 |
Scutellaria baicalensis inhibits liver fibrosis induced by bile duct ligation or carbon tetrachloride in rats.
Topics: Alanine Transaminase; Alkaline Phosphatase; Animals; Aspartate Aminotransferases; Body Weight; Carbon Tetrachloride; Drugs, Chinese Herbal; Hydroxyproline; Immunohistochemistry; Lamiaceae; Lipid Peroxidation; Liver; Liver Cirrhosis, Experimental; Male; Microscopy, Electron; Phytotherapy; Plant Extracts; Plant Roots; Rats; Rats, Sprague-Dawley; Thiobarbituric Acid Reactive Substances | 2002 |
Accelerated reversal of carbon tetrachloride-induced cirrhosis in rats by the endothelin receptor antagonist TAK-044.
Topics: Animals; Arteries; Blood Pressure; Carbon Tetrachloride; Collagen; Collagenases; Endothelin Receptor Antagonists; Endothelin-1; Hydroxyproline; Liver; Liver Cirrhosis; Male; Peptides, Cyclic; Portal Vein; Rats; Rats, Sprague-Dawley; Receptor, Endothelin A; Receptors, Endothelin; RNA, Messenger; Transforming Growth Factor beta; Transforming Growth Factor beta1 | 2002 |
The protective effect of taurine pretreatment on carbon tetrachloride-induced hepatic damage--a light and electron microscopic study.
Topics: Animals; Carbon Tetrachloride; Glutathione; Hydroxyproline; Liver; Male; Malondialdehyde; Protective Agents; Rats; Rats, Wistar; Taurine; Ultrasonography | 2002 |
Pirfenidone effectively reverses experimental liver fibrosis.
Topics: Alanine Transaminase; Alkaline Phosphatase; Animals; Aspartate Aminotransferases; Bile Ducts; Bilirubin; Carbon Tetrachloride; Hydroxyproline; Ligation; Liver; Liver Cirrhosis; Liver Regeneration; Male; Matrix Metalloproteinase 2; Prothrombin; Pyridones; Rats; Rats, Wistar | 2002 |
The collagenolytic effects of the traditional Chinese medicine preparation, Han-Dan-Gan-Le, contribute to reversal of chemical-induced liver fibrosis in rats.
Topics: Animals; Astragalus propinquus; Carbon Tetrachloride; Collagen Type I; Drugs, Chinese Herbal; Hydroxyproline; Injections, Subcutaneous; Liver; Liver Cirrhosis, Experimental; Male; Rats; Rats, Wistar | 2003 |
AT1A-deficient mice show less severe progression of liver fibrosis induced by CCl(4).
Topics: Animals; Base Sequence; Carbon Tetrachloride; DNA Primers; Enzyme-Linked Immunosorbent Assay; Hydroxyproline; Liver; Liver Cirrhosis, Experimental; Mice; Mice, Knockout; Receptor, Angiotensin, Type 1; Receptors, Angiotensin; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Transforming Growth Factor beta; Transforming Growth Factor beta1; Tumor Necrosis Factor-alpha | 2003 |
[Studies on the hormonal treatment of chronic liver diseases. Note V. Action of cortisone acetate on the histological and histochemical picture and on the hexosamine and hydroxyproline content of the cirrhotic liver (carbon tetrachloride-induced)].
Topics: Amino Sugars; Animals; Carbon Tetrachloride; Cortisone; Hexosamines; Hydroxyproline; Liver Cirrhosis, Experimental; Liver Diseases; Proline | 1959 |
EFFECT OF IRON LOADING UPON THE FORMATION OF COLLAGEN IN THE HEPATIC INJURY INDUCED BY CARBON TETRACHLORIDE.
Topics: Alanine Transaminase; Blood; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Collagen; Electrons; Ferritins; Golgi Apparatus; Hemochromatosis; Hepatitis; Hydroxyproline; Iron; Iron-Dextran Complex; Liver; Liver Cirrhosis; Microscopy; Microscopy, Electron; Pathology; Pharmacology; Rats; Research | 1964 |
Arg-Gly-Asp (RGD) peptide ameliorates carbon tetrachloride-induced liver fibrosis via inhibition of collagen production and acceleration of collagenase activity.
Topics: Animals; Carbon Tetrachloride; Cell Line; Collagen; Collagenases; Gene Expression Regulation; Humans; Hydroxyproline; Liver; Liver Cirrhosis; Male; Matrix Metalloproteinase 1; Oligopeptides; Rats; Rats, Wistar; Tissue Inhibitor of Metalloproteinase-1 | 2004 |
Taurine inhibits oxidative damage and prevents fibrosis in carbon tetrachloride-induced hepatic fibrosis.
Topics: Actins; Animals; Carbon Tetrachloride; Cells, Cultured; Dose-Response Relationship, Drug; Hydroxyproline; Immunohistochemistry; Lipid Peroxides; Liver; Liver Cirrhosis, Experimental; Male; Myocytes, Smooth Muscle; Osmolar Concentration; Oxidative Stress; Rats; Rats, Sprague-Dawley; RNA, Messenger; Taurine; Transforming Growth Factor beta; Transforming Growth Factor beta1 | 2005 |
Melatonin ameliorates carbon tetrachloride-induced hepatic fibrogenesis in rats via inhibition of oxidative stress.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Carbon Tetrachloride; Glutathione Peroxidase; Hydroxyproline; Interleukin-1; Kupffer Cells; Lipopolysaccharides; Liver; Liver Cirrhosis, Experimental; Male; Malondialdehyde; Melatonin; NF-kappa B; Oxidative Stress; Rats; Rats, Sprague-Dawley; Serum Albumin; Serum Globulins; Superoxide Dismutase; Tumor Necrosis Factor-alpha | 2005 |
[Proteomic analysis of proliferation and apoptosis in carbon tetrachloride induced rat liver fibrosis].
Topics: Animals; Apoptosis; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Caspase 12; Cell Proliferation; Hydroxyproline; Liver Cirrhosis, Experimental; Male; Proteins; Proteome; Rats; Rats, Wistar | 2005 |
Morphological signs of cirrhosis regression. Experimental observations on carbon tetrachloride-induced liver cirrhosis of rats.
Topics: Animals; Biomarkers; Biopsy; Carbon Tetrachloride; Disease Models, Animal; Female; Fluorescent Antibody Technique; Hepatocytes; Hydroxyproline; Liver; Liver Cirrhosis, Experimental; Male; Rats; Rats, Wistar; Recovery of Function; Remission, Spontaneous | 2005 |
Inhibition of CCl4-induced liver fibrosis by Piper longum Linn.?
Topics: Alanine Transaminase; Alkaline Phosphatase; Animals; Aspartate Aminotransferases; Bilirubin; Body Weight; Carbon Tetrachloride; Ethanol; Hydroxyproline; Liver; Liver Cirrhosis; Male; Phytotherapy; Piper; Plant Extracts; Rats; Rats, Wistar | 2006 |
[Experimental study of liver fibrosis reversal effect of warming-yang compound formula ganzhifu].
Topics: Animals; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Collagen Type I; Collagen Type IV; Drugs, Chinese Herbal; Female; Hydroxyproline; Liver; Liver Cirrhosis, Experimental; Male; Malondialdehyde; Phytotherapy; Rats; Rats, Wistar; Superoxide Dismutase | 2006 |
[Dynamic change of metabolism related protein in liver tissue of rats' model of hepatic fibrosis and regulatory effect of fuzheng huayu decoction on it].
Topics: Animals; Carbon Tetrachloride; Drugs, Chinese Herbal; Hydroxyproline; Liver; Liver Cirrhosis, Experimental; Male; Phosphoglycerate Kinase; Phytotherapy; Proteins; Random Allocation; Rats; Rats, Wistar | 2006 |
S-allyl cysteine attenuated CCl4-induced oxidative stress and pulmonary fibrosis in rats.
Topics: Animals; Bronchoalveolar Lavage Fluid; Carbon Tetrachloride; Cysteine; Enzyme Precursors; Glutathione; Hydroxyproline; Liver; Lung; Male; Matrix Metalloproteinase 9; Nitric Oxide; Nitric Oxide Synthase Type II; Oxidative Stress; Pulmonary Fibrosis; Rats; Rats, Wistar; Reactive Oxygen Species; Sulfhydryl Compounds; Transforming Growth Factor beta; Transforming Growth Factor beta1 | 2006 |
Filtrate of fermented mycelia from Antrodia camphorata reduces liver fibrosis induced by carbon tetrachloride in rats.
Topics: Animals; Base Sequence; Carbon Tetrachloride; Collagen Type I; Fermentation; Hydroxyproline; Liver Cirrhosis; Male; Malondialdehyde; Polyporales; Rats; Rats, Wistar; RNA, Messenger; Tissue Inhibitor of Metalloproteinase-1; Transforming Growth Factor beta; Transforming Growth Factor beta1 | 2006 |
[Study on pathogenesis of CCl4 induced cirrhosis formation in rats based on the recipe used].
Topics: Animals; Carbon Tetrachloride; Diagnosis, Differential; Drugs, Chinese Herbal; Hydroxyproline; Liver; Liver Cirrhosis, Experimental; Male; Medicine, Chinese Traditional; Phytotherapy; Random Allocation; Rats; Rats, Wistar; Yin Deficiency | 2006 |
Anti-fibrogenic function of angiotensin II type 2 receptor in CCl4-induced liver fibrosis.
Topics: Animals; Carbon Tetrachloride; Gene Expression Regulation; Hydroxyproline; Inflammation; Liver Cirrhosis; Mice; Mice, Inbred C57BL; Mice, Knockout; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; RNA, Messenger; Thiobarbituric Acid Reactive Substances; Transforming Growth Factor beta | 2006 |
Thalidomide in rat liver cirrhosis: blockade of tumor necrosis factor-alpha via inhibition of degradation of an inhibitor of nuclear factor-kappaB.
Topics: Actins; Alanine Transaminase; Animals; Aspartate Aminotransferases; Carbon Tetrachloride; Down-Regulation; Gene Expression Regulation; Hydroxyproline; I-kappa B Proteins; Immunosuppressive Agents; Liver; Liver Cirrhosis, Experimental; Male; NF-kappa B; NF-KappaB Inhibitor alpha; Rats; Rats, Wistar; RNA, Messenger; Thalidomide; Tumor Necrosis Factor-alpha | 2006 |
Therapeutic effect of Chinese medicine formula DSQRL on experimental pulmonary fibrosis.
Topics: Animals; Bronchoalveolar Lavage Fluid; Carbon Tetrachloride; Collagen; Disease Models, Animal; Drugs, Chinese Herbal; Hydroxyproline; Lung; Male; Medicine, Chinese Traditional; Prednisone; Pulmonary Fibrosis; Rats; Rats, Sprague-Dawley | 2007 |
JinSanE decoction, a chinese herbal medicine, inhibits expression of TGF-beta1/Smads in experimental hepatic fibrosis in rats.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Carbon Tetrachloride; Drugs, Chinese Herbal; Hyaluronic Acid; Hydroxyproline; Immunohistochemistry; Liver; Liver Cirrhosis; Protein Serine-Threonine Kinases; Random Allocation; Rats; Rats, Wistar; Receptor, Transforming Growth Factor-beta Type II; Receptors, Transforming Growth Factor beta; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Signal Transduction; Smad3 Protein; Smad7 Protein; Transforming Growth Factor beta1 | 2006 |
Protective effect of verapamil on multiple hepatotoxic factors-induced liver fibrosis in rats.
Topics: Actins; Alanine Transaminase; Animals; Carbon Tetrachloride; Collagen; Dietary Fats; Disease Models, Animal; Dose-Response Relationship, Drug; Hydroxyproline; Liver; Liver Cirrhosis; Male; Malondialdehyde; Necrosis; Protective Agents; Rats; Rats, Wistar; Transforming Growth Factor beta1; Verapamil | 2007 |
[Experimental study of two histological quantitative methods of hepatic fibrosis].
Topics: Animals; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Drugs, Chinese Herbal; Female; Hydroxyproline; Image Processing, Computer-Assisted; Liver; Liver Cirrhosis, Experimental; Male; Phytotherapy; Rats; Rats, Wistar | 2007 |
Measurement of liver collagen synthesis by heavy water labeling: effects of profibrotic toxicants and antifibrotic interventions.
Topics: Administration, Oral; Alanine; Animals; Atorvastatin; Carbon Tetrachloride; Collagen; Deuterium Oxide; Drug Evaluation, Preclinical; Enalapril; Gas Chromatography-Mass Spectrometry; Griseofulvin; Heptanoic Acids; Hydroxyproline; Interferon-gamma; Liver; Liver Cirrhosis, Experimental; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Pyrroles; Rats; Rats, Sprague-Dawley; Reproducibility of Results; Rosiglitazone; Species Specificity; Thiazolidinediones; Time Factors | 2007 |
Contribution of mononuclear bone marrow cells to carbon tetrachloride-induced liver fibrosis in rats.
Topics: Animals; Bone Marrow Cells; Bone Marrow Transplantation; Carbon Tetrachloride; Collagen; Disease Models, Animal; Hydroxyproline; Liver; Liver Cirrhosis, Experimental; Liver Regeneration; Random Allocation; Rats; Rats, Inbred F344; Rats, Wistar | 2007 |
A fermented substance from Aspergillus phoenicis reduces liver fibrosis induced by carbon tetrachloride in rats.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Aspergillus; Carbon Tetrachloride; Collagen Type I; Collagen Type III; Fermentation; Hydroxyproline; Liver; Liver Cirrhosis, Experimental; Male; Malondialdehyde; Matrix Metalloproteinase 13; Methionine Adenosyltransferase; Organ Size; Protective Agents; Random Allocation; Rats; Rats, Wistar; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Serum Albumin; Spleen; Tissue Inhibitor of Metalloproteinase-1; Transforming Growth Factor beta1 | 2007 |
Effects and mechanisms of extract from Paeonia lactiflora and Astragalus membranaceus on liver fibrosis induced by carbon tetrachloride in rats.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Astragalus Plant; Carbon Tetrachloride; Cell Proliferation; Collagen; Collagen Type III; Dose-Response Relationship, Drug; Glutathione Peroxidase; Hepatocytes; Hyaluronic Acid; Hydroxyproline; Injections, Subcutaneous; Laminin; Lipid Peroxidation; Liver Cirrhosis, Experimental; Male; Malondialdehyde; Paeonia; Plant Extracts; Rats; Rats, Sprague-Dawley; Superoxide Dismutase; Transforming Growth Factor beta1 | 2007 |
Cystamine ameliorates liver fibrosis induced by carbon tetrachloride via inhibition of tissue transglutaminase.
Topics: Actins; Animals; Carbon Tetrachloride; Collagen; Cystamine; Disease Progression; Enzyme Inhibitors; Hydroxyproline; Liver; Liver Cirrhosis; Rats; Rats, Sprague-Dawley; Tissue Inhibitor of Metalloproteinase-1; Transglutaminases | 2007 |
Treatment of chronic liver injuries in mice by oral administration of ethanolic extract of the fruit of Hovenia dulcis.
Topics: Administration, Oral; Animals; Aspartate Aminotransferase, Cytoplasmic; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury, Chronic; Collagen Type I; Collagen Type III; Disease Models, Animal; Drugs, Chinese Herbal; Hydroxyproline; Lipid Peroxidation; Liver; Male; Methionine Adenosyltransferase; Mice; Mice, Inbred ICR; Phytotherapy; Rhamnaceae | 2007 |
Hepatic viscoelastic parameters measured with MR elastography: correlations with quantitative analysis of liver fibrosis in the rat.
Topics: Animals; Automation; Carbon Tetrachloride; Elasticity; Elasticity Imaging Techniques; Fibrosis; Hydroxyproline; Image Processing, Computer-Assisted; Liver; Liver Cirrhosis; Liver Diseases; Magnetic Resonance Imaging; Rats; Viscosity | 2007 |
Inhibition of the renin-angiotensin system attenuates the development of liver fibrosis and oxidative stress in rats.
Topics: Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme Inhibitors; Animals; Antioxidants; Carbon Tetrachloride; Disease Models, Animal; Dose-Response Relationship, Drug; Fosinopril; Glutathione; Hydroxyproline; Lipid Peroxidation; Lisinopril; Liver; Liver Cirrhosis; Liver Function Tests; Losartan; Male; Oxidative Stress; Rats; Renin-Angiotensin System | 2008 |
A novel synthetic oleanolic acid derivative (CPU-II2) attenuates liver fibrosis in mice through regulating the function of hepatic stellate cells.
Topics: Actins; Animals; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Cell Line; Cell Survival; Collagen Type I; Collagen Type I, alpha 1 Chain; Down-Regulation; Hydroxyproline; Liver; Liver Cirrhosis, Experimental; Male; MAP Kinase Signaling System; Mice; Mice, Inbred ICR; Oleanolic Acid; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Tissue Inhibitor of Metalloproteinase-1 | 2008 |
Protection by and anti-oxidant mechanism of berberine against rat liver fibrosis induced by multiple hepatotoxic factors.
Topics: Actins; Alanine Transaminase; Animals; Aspartate Aminotransferases; Berberine; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Cholesterol; Dose-Response Relationship, Drug; Ethanol; Hydroxyproline; Liver; Liver Cirrhosis; Male; Malondialdehyde; Rats; Rats, Wistar | 2008 |
Corn oil enhancing hepatic lipid peroxidation induced by CCl4 does not aggravate liver fibrosis in rats.
Topics: Animals; Aspartate Aminotransferases; Carbon Tetrachloride; Corn Oil; Dinoprost; Hydroxyproline; Lipid Peroxidation; Liver; Liver Cirrhosis; Liver Function Tests; Male; Malondialdehyde; Organ Size; Protein Carbonylation; Rats; Rats, Wistar; Reproducibility of Results; Reverse Transcriptase Polymerase Chain Reaction; Serum Albumin; Triglycerides | 2008 |
Coagulation status modulates murine hepatic fibrogenesis: implications for the development of novel therapies.
Topics: Actins; Animals; Anticoagulants; Carbon Tetrachloride; Factor V; Gene Expression; Hydroxyproline; Lipid Peroxidation; Liver; Liver Cirrhosis, Experimental; Male; Mice; Mice, Congenic; Mice, Inbred C57BL; Mice, Mutant Strains; Mice, Transgenic; Point Mutation; Warfarin | 2008 |
Platelets contribute to the reduction of liver fibrosis in mice.
Topics: Animals; Blood Platelets; Carbon Tetrachloride; Cell Proliferation; Disease Models, Animal; Female; Gene Expression Regulation; Hydroxyproline; Liver; Liver Cirrhosis; Liver Regeneration; Matrix Metalloproteinase 9; Mice; Mice, Inbred C57BL; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitotic Index; Phosphorylation; Platelet Count; Proto-Oncogene Proteins c-akt; RNA, Messenger; Splenectomy; Thrombocytosis; Thrombopoietin; Transforming Growth Factor beta | 2009 |
Lipid peroxidation products do not activate hepatic stellate cells.
Topics: Alanine Transaminase; Animals; Apoptosis; Aspartate Aminotransferases; Carbon Tetrachloride; Cell Survival; Collagen Type I; Corn Oil; Cyclooxygenase 2; Dinoprost; Hepatic Stellate Cells; Hydroxyproline; Lipid Peroxidation; Liver; Liver Cirrhosis; Liver Function Tests; Male; Malondialdehyde; Microscopy, Confocal; Protein Carbonylation; Rats; Rats, Wistar; Transforming Growth Factor beta1 | 2008 |
Newly proposed fibrosis staging criterion for assessing carbon tetrachloride- and albumin complex-induced liver fibrosis in rodents.
Topics: Animals; Antigen-Antibody Complex; Carbon Tetrachloride; Humans; Hydroxyproline; Image Processing, Computer-Assisted; Liver Cirrhosis, Experimental; Male; Mice; Mice, Inbred BALB C; Observer Variation; Rats; Rats, Wistar; Reproducibility of Results; Serum Albumin | 2008 |
Trolox down-regulates transforming growth factor-beta and prevents experimental cirrhosis.
Topics: Alanine Transaminase; Alkaline Phosphatase; Animals; Antioxidants; Blotting, Western; Carbon Tetrachloride; Chromans; Down-Regulation; gamma-Glutamyltransferase; Glutathione; Glycogen; Hydroxyproline; Lipid Peroxidation; Liver Cirrhosis, Experimental; Male; Rats; Rats, Wistar; Transforming Growth Factor beta | 2008 |
Protective effects of total flavonoids of Bidens bipinnata L. against carbon tetrachloride-induced liver fibrosis in rats.
Topics: Actins; Alanine Transaminase; Animals; Aspartate Aminotransferases; Bidens; Carbon Tetrachloride; Collagen Type III; Dose-Response Relationship, Drug; Flavonoids; Glutathione Peroxidase; Hydroxyproline; Liver; Liver Cirrhosis; Male; NF-kappaB-Inducing Kinase; Organ Size; Phytotherapy; Protein Serine-Threonine Kinases; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Spleen; Superoxide Dismutase; Thiobarbituric Acid Reactive Substances; Transforming Growth Factor beta1 | 2008 |
Inhibitory effect of olive oil on fibrosis induced by carbon tetrachloride in rat liver.
Topics: Animals; Blotting, Western; Body Weight; Carbon Tetrachloride; Catalase; Collagen; Glutathione Peroxidase; Hydroxyproline; Immunohistochemistry; Lipid Peroxidation; Liver Cirrhosis; Male; Malondialdehyde; Olive Oil; Plant Oils; Random Allocation; Rats; Rats, Wistar; Reverse Transcriptase Polymerase Chain Reaction; Superoxide Dismutase; Transforming Growth Factor beta1 | 2008 |
Action mechanism of Yi Guan Jian Decoction on CCl4 induced cirrhosis in rats.
Topics: Administration, Oral; Animals; Apoptosis; Carbon Tetrachloride; Drugs, Chinese Herbal; Hepatic Stellate Cells; Hepatocytes; Hydroxyproline; Kupffer Cells; Liver; Liver Cirrhosis, Experimental; Male; Phytotherapy; Rats; Rats, Wistar | 2009 |
Aquilegia vulgaris extract attenuates carbon tetrachloride-induced liver fibrosis in rats.
Topics: Animals; Aquilegia; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Fibrosis; Glutathione; Hydroxyproline; Lipid Peroxidation; Liver Diseases; Male; Phytotherapy; Plant Extracts; Rats; Rats, Wistar; Silymarin | 2009 |
Protective effect of a mixture of Aloe vera and Silybum marianum against carbon tetrachloride-induced acute hepatotoxicity and liver fibrosis.
Topics: Alanine Transaminase; Aloe; Animals; Aspartate Aminotransferases; Carbon Tetrachloride; Complex Mixtures; Cyclooxygenase 2; Cytochrome P-450 CYP2E1; Dose-Response Relationship, Drug; Drug Combinations; Enzyme-Linked Immunosorbent Assay; Glutathione; Hydroxyproline; Liver; Liver Cirrhosis; Liver Failure, Acute; Nitric Oxide Synthase Type II; Phytotherapy; Plant Extracts; Protective Agents; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction; Silybum marianum; Tissue Inhibitor of Metalloproteinase-1; Tumor Necrosis Factor-alpha | 2009 |
The protective effects of a fermented substance from Saccharomyces cerevisiae on carbon tetrachloride-induced liver damage in rats.
Topics: Animals; Carbon Tetrachloride; Collagen Type I; Dose-Response Relationship, Drug; Fermentation; Hydroxyproline; Liver Cirrhosis, Experimental; Male; Malondialdehyde; Methionine Adenosyltransferase; Organ Size; Random Allocation; Rats; Rats, Wistar; RNA, Messenger; Saccharomyces cerevisiae; Serum Albumin; Transaminases; Transforming Growth Factor beta1 | 2009 |
Melatonin ameliorates experimental hepatic fibrosis induced by carbon tetrachloride in rats.
Topics: Animals; Carbon Tetrachloride; Glutathione Peroxidase; Hyaluronic Acid; Hydroxyproline; Laminin; Liver Cirrhosis; Liver Function Tests; Male; Malondialdehyde; Melatonin; Peptide Fragments; Procollagen; Rats; Rats, Sprague-Dawley | 2009 |
Relaxin reduces fibrosis in models of progressive and established hepatic fibrosis.
Topics: Actins; Animals; Carbon Tetrachloride; Collagen; Disease Models, Animal; Hydroxyproline; Liver; Liver Cirrhosis; Mice; Muscle, Smooth; Relaxin; Swine | 2009 |
Effect of oxymatrine on the p38 mitogen-activated protein kinases signalling pathway in rats with CCl4 induced hepatic fibrosis.
Topics: Actins; Alkaloids; Animals; Anti-Arrhythmia Agents; Carbon Tetrachloride; Collagen; Collagen Type IV; Hyaluronic Acid; Hydroxyproline; Laminin; Liver Cirrhosis; Male; p38 Mitogen-Activated Protein Kinases; Procollagen; Quinolizines; Rats; Rats, Sprague-Dawley; Signal Transduction | 2009 |
Effect of Laggera alata on hepatocyte damage induced by carbon tetrachloride in vitro and in vivo.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Asteraceae; Blood Proteins; Carbon Tetrachloride; Cell Survival; Chemical and Drug Induced Liver Injury; Disease Models, Animal; Drug Evaluation, Preclinical; Drugs, Chinese Herbal; Hepatocytes; Hydroxyproline; Male; Mice; Mice, Inbred ICR; N-Acetylneuraminic Acid; Phytotherapy; Plant Extracts; Quinic Acid; Rats; Rats, Sprague-Dawley; Serum Albumin | 2009 |
Emodin protects rat liver from CCl(4)-induced fibrogenesis via inhibition of hepatic stellate cells activation.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Carbon Tetrachloride; Disease Models, Animal; Emodin; Fibrosis; Hepatic Stellate Cells; Hydroxyproline; Immunohistochemistry; Liver; Male; Olive Oil; Plant Oils; Rats; Rats, Sprague-Dawley | 2009 |
Antifibrotic effects of chronic baicalein administration in a CCl4 liver fibrosis model in rats.
Topics: Animals; Biomarkers; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Down-Regulation; Fibrillar Collagens; Flavanones; Hyaluronic Acid; Hydroxyproline; Laminin; Liver; Liver Cirrhosis; Liver Function Tests; Male; Matrix Metalloproteinases; Protective Agents; Random Allocation; Rats; Rats, Sprague-Dawley; Receptor, Platelet-Derived Growth Factor beta; Time Factors | 2010 |
Curcumin and saikosaponin a inhibit chemical-induced liver inflammation and fibrosis in rats.
Topics: Animals; Anti-Inflammatory Agents; Bupleurum; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Collagen; Curcuma; Curcumin; Cytokines; Dietary Supplements; Drug Therapy, Combination; Fibrosis; Hydroxyproline; Inflammation; Liver; Male; NF-kappa B; Oleanolic Acid; Phytotherapy; Plant Extracts; Plant Roots; Random Allocation; Rats; Rats, Sprague-Dawley; Rhizome; Saponins; Transforming Growth Factor beta1 | 2010 |
Effects of Haobie Yangyin Ruanjian decoction on hepatic fibrosis induced by carbon tetrachloride in rats.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Biomarkers; Blotting, Western; Carbon Tetrachloride; Collagen Type III; Collagen Type IV; Disease Models, Animal; Drugs, Chinese Herbal; Female; Hyaluronic Acid; Hydroxyproline; Laminin; Liver; Liver Cirrhosis; Male; Radioimmunoassay; Rats; Rats, Wistar; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Signal Transduction; Smad3 Protein; Transforming Growth Factor beta1 | 2010 |
Carotenoid lutein protects rats from paracetamol-, carbon tetrachloride- and ethanol-induced hepatic damage.
Topics: Acetaminophen; Alanine Transaminase; Alkaline Phosphatase; Animals; Antioxidants; Aspartate Aminotransferases; Bilirubin; Biomarkers; Carbon Tetrachloride; Catalase; Chemical and Drug Induced Liver Injury; Cytoprotection; Disease Models, Animal; Dose-Response Relationship, Drug; Ethanol; Glutathione Peroxidase; Hydroxyproline; Lipid Peroxidation; Liver; Lutein; Male; Oxidative Stress; Rats; Rats, Wistar; Superoxide Dismutase | 2010 |
Hepatoprotection by freshwater clam extract against CCl4-induced hepatic damage in rats.
Topics: Alanine Transaminase; Animals; Anti-Inflammatory Agents; Antioxidants; Aspartate Aminotransferases; Biological Products; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Corbicula; Hydroxyproline; Inflammation; Liver; Liver Cirrhosis; Male; Oxidative Stress; Rats; Rats, Sprague-Dawley; Thiobarbituric Acid Reactive Substances | 2010 |
Peroxisome proliferator-activated receptor gamma inhibits hepatic fibrosis in rats.
Topics: Actins; Animals; Carbon Tetrachloride; Cell Proliferation; Cells, Cultured; Collagen Type I; Gene Expression; Hepatic Stellate Cells; Hydroxyproline; Liver; Liver Cirrhosis; Male; PPAR gamma; Rats; Rats, Sprague-Dawley; Transfection | 2011 |
N-methyl-4-isoleucine cyclosporine attenuates CCl -induced liver fibrosis in rats by interacting with cyclophilin B and D.
Topics: Actins; Alanine Transaminase; Analysis of Variance; Animals; Aspartate Aminotransferases; Carbon Tetrachloride; Cell Line; Collagen Type III; Cyclophilins; Cyclosporine; Cytoprotection; Dose-Response Relationship, Drug; Hepatic Stellate Cells; Hydroxyproline; Liver; Liver Cirrhosis, Experimental; Male; Matrix Metalloproteinase 13; Peptidyl-Prolyl Isomerase F; Rats; Rats, Wistar; RNA Interference; RNA, Messenger; Serum Albumin; Time Factors; Tissue Inhibitor of Metalloproteinase-1; Transforming Growth Factor beta | 2011 |
Attenuated liver fibrosis after bile duct ligation and defective hepatic stellate cell activation in neural cell adhesion molecule knockout mice.
Topics: Actins; Animals; Blotting, Western; Carbon Tetrachloride; Cell Separation; Cells, Cultured; Cholestasis, Extrahepatic; Collagen; Common Bile Duct; Desmin; Fibronectins; Hepatic Stellate Cells; Hydroxyproline; Immunohistochemistry; Laminin; Ligation; Liver; Liver Cirrhosis, Experimental; Mice; Mice, Inbred C57BL; Mice, Knockout; Neural Cell Adhesion Molecules; Time Factors; Transforming Growth Factor beta1 | 2011 |
Effects and mechanisms of Acremoniumterricola milleretal mycelium on liver fibrosis induced by carbon tetrachloride in rats.
Topics: Acremonium; Animals; Antioxidants; Biological Products; Carbon Tetrachloride; Disease Models, Animal; Drugs, Chinese Herbal; Glutathione Peroxidase; Hyaluronic Acid; Hydroxyproline; Laminin; Lipid Peroxidation; Liver; Liver Cirrhosis; Male; Mycelium; Phosphorylation; Procollagen; Rats; Rats, Sprague-Dawley; Signal Transduction; Smad Proteins; Superoxide Dismutase; Transaminases; Transforming Growth Factor beta1 | 2011 |
Hepatoprotective effects and mechanisms of dehydrocavidine in rats with carbon tetrachloride-induced hepatic fibrosis.
Topics: Animals; Antioxidants; Apoptosis; Berberine Alkaloids; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Corydalis; Cytokines; Gene Expression; Hydroxyproline; Liver; Liver Cirrhosis; Male; Malondialdehyde; Microarray Analysis; Phytotherapy; Plant Extracts; Rats; Rats, Sprague-Dawley; Weight Loss | 2011 |
Expression of the megalin C-terminal fragment by macrophages during liver fibrogenesis in mice.
Topics: Alanine Transaminase; Animals; Carbon Tetrachloride; Cloning, Molecular; Flow Cytometry; Hydroxyproline; Liver; Liver Cirrhosis; Low Density Lipoprotein Receptor-Related Protein-2; Macrophages; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Peptide Fragments; Protein Structure, Tertiary; Rabbits; Real-Time Polymerase Chain Reaction; Recombinant Fusion Proteins | 2011 |
Hydrogen sulfide attenuates carbon tetrachloride-induced hepatotoxicity, liver cirrhosis and portal hypertension in rats.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Blood Pressure; Carbon Tetrachloride; Cystathionine gamma-Lyase; Cytochrome P-450 CYP2E1; Glutathione; Hydrogen Sulfide; Hydroxyproline; Hypertension, Portal; Inflammation; Liver; Liver Cirrhosis; Liver Function Tests; Male; Malondialdehyde; Organ Size; Rats; Rats, Wistar; Toxicity Tests, Acute | 2011 |
Hepatoprotective and antioxidant effects of licorice extract against CCl₄-induced oxidative damage in rats.
Topics: Alanine Transaminase; Alkaline Phosphatase; Animals; Antioxidants; Aspartate Aminotransferases; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Drugs, Chinese Herbal; Glycyrrhiza; Hydroxyproline; Liver; Oxidative Stress; Oxidoreductases; Plant Extracts; Protective Agents; Rats; Rats, Wistar; Tumor Necrosis Factor-alpha; Water | 2011 |
Protease-activated receptor 2 promotes experimental liver fibrosis in mice and activates human hepatic stellate cells.
Topics: Animals; Carbon Tetrachloride; Cell Proliferation; Cells, Cultured; Collagen; Cytokines; Disease Models, Animal; Disease Progression; Hepatic Stellate Cells; Humans; Hydroxyproline; In Vitro Techniques; Liver; Liver Cirrhosis; Male; Matrix Metalloproteinase 2; Mice; Mice, Inbred C57BL; Mice, Knockout; Oligopeptides; Receptor, PAR-2; Tissue Inhibitor of Metalloproteinase-1; Transforming Growth Factor beta | 2012 |
Magnesium chenoursodeoxycholic acid ameliorates carbon tetrachloride-induced liver fibrosis in rats.
Topics: Actins; Alanine Transaminase; Animals; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Cyclooxygenase 2; Glutathione; Hydroxyproline; Interleukin-10; Interleukin-6; JNK Mitogen-Activated Protein Kinases; Lipid Peroxidation; Liver; Liver Cirrhosis; Male; Matrix Metalloproteinase 2; NF-kappa B; Organometallic Compounds; Oxidative Stress; Random Allocation; Rats; Rats, Sprague-Dawley; RNA, Messenger; Tissue Inhibitor of Metalloproteinase-1; Toll-Like Receptor 4; Transforming Growth Factor beta1; Tumor Necrosis Factor-alpha | 2012 |
Antifibrotic effects of Artemisia capillaris and Artemisia iwayomogi in a carbon tetrachloride-induced chronic hepatic fibrosis animal model.
Topics: Alkaline Phosphatase; Animals; Antioxidants; Artemisia; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Chronic Disease; Collagen; Cytokines; Disease Models, Animal; Down-Regulation; Fatty Liver; Glutathione; Hydroxyproline; Inflammation; Korea; Liver; Liver Cirrhosis; Male; Malondialdehyde; Phytotherapy; Plant Extracts; Rats; Rats, Sprague-Dawley; Superoxide Dismutase; Transaminases | 2012 |
C/EBP-α ameliorates CCl(4)-induced liver fibrosis in mice through promoting apoptosis of hepatic stellate cells with little apoptotic effect on hepatocytes in vitro and in vivo.
Topics: Actins; Animals; Apoptosis; Carbon Tetrachloride; Caspases; CCAAT-Enhancer-Binding Protein-alpha; Cells, Cultured; Collagen; DNA Fragmentation; Extracellular Matrix; gamma-Glutamyltransferase; Gene Expression; Hepatic Stellate Cells; Hepatocytes; Hydroxyproline; Liver Cirrhosis; Male; Mice; Mice, Inbred BALB C; Rats; Recombinant Proteins | 2012 |
Polyprenols from Taxus chinensis var. mairei prevent the development of CCl₄-induced liver fibrosis in rats.
Topics: Animals; Carbon Tetrachloride; Collagen; Female; Glutathione; Glutathione Peroxidase; Hydroxyproline; Lipid Peroxidation; Liver Cirrhosis; Malondialdehyde; Oxidative Stress; Phytotherapy; Plant Extracts; Plant Leaves; Protective Agents; Rats; Rats, Sprague-Dawley; Superoxide Dismutase; Taxus; Thiobarbituric Acid Reactive Substances | 2012 |
Molecular MR imaging of liver fibrosis: a feasibility study using rat and mouse models.
Topics: Animals; Carbon Tetrachloride; Collagen Type I; Contrast Media; Diethylnitrosamine; Disease Models, Animal; Gadolinium; Half-Life; Hydroxyproline; Liver; Liver Cirrhosis; Magnetic Resonance Imaging; Male; Mice; Molecular Imaging; Molecular Probes; Rats; Rats, Wistar | 2012 |
Silymarin decreases connective tissue growth factor to improve liver fibrosis in rats treated with carbon tetrachloride.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Carbon Tetrachloride; Connective Tissue Growth Factor; Glutathione Peroxidase; Hydroxyproline; Liver Cirrhosis; Male; Rats; Rats, Wistar; Silymarin; Superoxide Dismutase | 2013 |
Effect and mechanism of methyl helicterate isolated from Helicteres angustifolia (Sterculiaceae) on hepatic fibrosis induced by carbon tetrachloride in rats.
Topics: Alanine Transaminase; Animals; Antioxidants; Aspartate Aminotransferases; Carbon Tetrachloride; Collagen Type III; Glutathione Peroxidase; Hyaluronic Acid; Hydroxyproline; Laminin; Lipid Peroxidation; Liver Cirrhosis; Male; Malvaceae; Phytotherapy; Rats; Rats, Sprague-Dawley; RNA, Messenger; Smad3 Protein; Superoxide Dismutase; Transforming Growth Factor beta1; Triterpenes | 2012 |
[Comparison of effect of formulas clearing away heat and promoting blood circulation on prevention and treatment of liver fibrosis in CCl4 mice].
Topics: Animals; Blood Circulation; Body Temperature; Carbon Tetrachloride; Drugs, Chinese Herbal; Hydroxyproline; Liver; Liver Cirrhosis; Male; Mice; Mice, Inbred C57BL; Organ Size | 2012 |
Green tea extract supplementation ameliorates CCl4-induced hepatic oxidative stress, fibrosis, and acute-phase protein expression in rat.
Topics: Alanine Transaminase; Animals; Antioxidants; Ascorbic Acid; Aspartate Aminotransferases; beta Carotene; Bile; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury, Chronic; Female; Hydroxyproline; Lipid Metabolism; Liver Cirrhosis; Oxidative Stress; Phytotherapy; Plant Extracts; Proto-Oncogene Proteins c-bcl-2; Rats; Rats, Wistar; Reactive Oxygen Species; Tea; Vitamin E | 2012 |
Anti-fibrotic effects of puerarin on CCl4-induced hepatic fibrosis in rats possibly through the regulation of PPAR-γ expression and inhibition of PI3K/Akt pathway.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Bilirubin; Carbon Tetrachloride; Collagen Type I; Collagen Type III; Down-Regulation; Extracellular Matrix; Hepatocytes; Hydroxyproline; Isoflavones; Liver; Liver Cirrhosis; Male; Matrix Metalloproteinase 2; Phosphatidylinositol 3-Kinases; PPAR gamma; Proto-Oncogene Proteins c-akt; Pueraria; Rats; Rats, Wistar; Serum Albumin; Tissue Inhibitor of Metalloproteinase-1; Up-Regulation; Vasodilator Agents | 2013 |
Association of age-dependent liver injury and fibrosis with immune cell populations.
Topics: Age Factors; Aging; Alanine Transaminase; Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Collagen Type I; Collagen Type I, alpha 1 Chain; Cytokines; Disease Models, Animal; Fibronectins; Hydroxyproline; Liver; Liver Cirrhosis, Experimental; Lymphocyte Subsets; Macrophages; Male; Mice; Mice, Inbred BALB C; RNA, Messenger | 2013 |
Recombinant bovine pancreatic trypsin inhibitor protects the liver from carbon tetrachloride-induced chronic injury in rats.
Topics: Alanine Transaminase; Animals; Aprotinin; Aspartate Aminotransferases; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury, Chronic; Cytoprotection; Disease Models, Animal; Fatty Liver; Hydroxyproline; Inflammation Mediators; Interleukin-1beta; Liver; Liver Cirrhosis, Experimental; Male; Necrosis; Protective Agents; Rats; Rats, Wistar; Recombinant Proteins; Superoxide Dismutase; Thiobarbituric Acid Reactive Substances; Transforming Growth Factor beta | 2013 |
Recombinant human histidine triad nucleotide-binding protein 1 attenuates liver fibrosis induced by carbon tetrachloride in rats.
Topics: Animals; Carbon Tetrachloride; Hepatic Stellate Cells; Humans; Hydroxyproline; Liver; Liver Cirrhosis; Male; Nerve Tissue Proteins; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Smad3 Protein; Smad7 Protein; Transforming Growth Factor beta1 | 2013 |
Human platelets inhibit liver fibrosis in severe combined immunodeficiency mice.
Topics: Actins; Animals; Biomarkers; Carbon Tetrachloride; Caspase 3; Hepatocyte Growth Factor; Hepatocytes; Humans; Hydroxyproline; Liver; Liver Cirrhosis, Experimental; Male; Matrix Metalloproteinase 9; Mice; Mice, SCID; Phosphorylation; Platelet Transfusion; Proto-Oncogene Proteins c-bcl-2; Proto-Oncogene Proteins c-met; Signal Transduction; Smad3 Protein; Time Factors; Transforming Growth Factor beta | 2013 |
Effects of Fufang Biejia Ruangan pills on hepatic fibrosis in vivo and in vitro.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Biomarkers; Carbon Tetrachloride; Cell Cycle; Cell Line; Cell Proliferation; Collagen Type III; Collagen Type IV; Drugs, Chinese Herbal; Female; Hepatocytes; Humans; Hyaluronic Acid; Hydroxyproline; Laminin; Liver; Liver Cirrhosis, Experimental; Male; Medicine, Chinese Traditional; Procollagen; Rats; Rats, Wistar; Smad3 Protein; Tablets; Transforming Growth Factor beta1 | 2013 |
The hepatoprotective effect of fraxetin on carbon tetrachloride induced hepatic fibrosis by antioxidative activities in rats.
Topics: Animals; Carbon Tetrachloride; Catalase; Chemical and Drug Induced Liver Injury; Coumarins; Glutathione Peroxidase; Hydroxyproline; Lipid Peroxidation; Liver; Liver Cirrhosis; Male; Protective Agents; Rats; Rats, Sprague-Dawley; Superoxide Dismutase | 2013 |
Modulation of carbon tetrachloride-induced hepatic oxidative stress, injury and fibrosis by olmesartan and omega-3.
Topics: Actins; Animals; Biomarkers; Carbon Tetrachloride; Drug Therapy, Combination; Fatty Acids, Omega-3; Hydroxyproline; Imidazoles; Liver; Liver Cirrhosis, Experimental; Male; Oxidative Stress; Rats; Rats, Wistar; Receptor, Platelet-Derived Growth Factor beta; Tetrazoles; Transforming Growth Factor beta1 | 2014 |
Protection effect of kallistatin on carbon tetrachloride-induced liver fibrosis in rats via antioxidative stress.
Topics: Animals; Antioxidants; Biomarkers; Carbon Tetrachloride; Cell Line; Collagen Type III; Hepatic Stellate Cells; Humans; Hyaluronic Acid; Hydrogen Peroxide; Hydroxyproline; Inflammation; Laminin; Liver; Liver Cirrhosis; Male; Oxidative Stress; Pichia; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Serpins | 2014 |
Therapeutic potential of morin against liver fibrosis in rats: modulation of oxidative stress, cytokine production and nuclear factor kappa B.
Topics: Alanine Transaminase; Alkaline Phosphatase; Animals; Aspartate Aminotransferases; Bilirubin; Carbon Tetrachloride; Flavonoids; Hydroxyproline; Liver; Liver Cirrhosis; Male; NF-kappa B; Nitric Oxide Synthase Type II; Oxidative Stress; Protective Agents; Rats; Silymarin; Tumor Necrosis Factor-alpha | 2014 |
Therapeutic potential of amniotic-fluid-derived stem cells on liver fibrosis model in mice.
Topics: Alanine Transaminase; Amniotic Fluid; Animals; Aspartate Aminotransferases; Carbon Tetrachloride; Disease Models, Animal; Fetal Stem Cells; Hydroxyproline; Liver; Liver Cirrhosis; Male; Mice; Mice, Inbred ICR; Serum Albumin | 2014 |
Chloroquine improved carbon tetrachloride-induced liver fibrosis through its inhibition of the activation of hepatic stellate cells: role of autophagy.
Topics: Actins; Alanine Transaminase; Animals; Aspartate Aminotransferases; Autophagy; Carbon Tetrachloride; Chloroquine; Hepatic Stellate Cells; Hydroxyproline; Liver; Liver Cirrhosis, Experimental; Male; Microtubule-Associated Proteins; Protective Agents; Rats, Sprague-Dawley | 2014 |
Fuzheng Huayu recipe alleviates hepatic fibrosis via inhibiting TNF-α induced hepatocyte apoptosis.
Topics: Actins; Amino Acid Chloromethyl Ketones; Animals; Apoptosis; bcl-2-Associated X Protein; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Drugs, Chinese Herbal; Enzyme Inhibitors; Hepatic Stellate Cells; Hepatocytes; Hydroxyproline; Liver; Liver Cirrhosis; Male; Mice, Inbred C57BL; Phytotherapy; Proto-Oncogene Proteins c-bcl-2; Receptors, Tumor Necrosis Factor, Type I; Tumor Necrosis Factor-alpha | 2014 |
Role of Fn14 in acute alcoholic steatohepatitis in mice.
Topics: Acute Disease; Animals; Apoptosis; Carbon Tetrachloride; Cell Proliferation; Disease Models, Animal; Ethanol; Fatty Liver, Alcoholic; Hydroxyproline; Inflammation Mediators; Liver; Liver Cirrhosis, Alcoholic; Male; Mice, Inbred C57BL; Mice, Knockout; Receptors, Tumor Necrosis Factor; Signal Transduction; Time Factors; Tumor Necrosis Factor-alpha; TWEAK Receptor; Wound Healing | 2015 |
[Effect of alcohol extract of Plumula Nelumbini on carbon tetrachloride induced rat liver fibrosis: an experimental study].
Topics: Alanine Transaminase; Animals; Carbon Tetrachloride; Collagen; Drugs, Chinese Herbal; Ethanol; Hepatic Stellate Cells; Hydroxyproline; Lipid Peroxidation; Liver Cirrhosis, Experimental; Male; Malondialdehyde; Rats; Superoxide Dismutase | 2014 |
A Targeted Multiple Antigenic Peptide Vaccine Augments the Immune Response to Self TGF-β1 and Suppresses Ongoing Hepatic Fibrosis.
Topics: Actins; Alanine Transaminase; Amino Acid Sequence; Animals; Aspartate Aminotransferases; Bilirubin; Body Weight; Carbon Tetrachloride; Chromatography, High Pressure Liquid; Enzyme-Linked Immunosorbent Assay; Epitopes; Freund's Adjuvant; Hydroxyproline; Immune Tolerance; Insulin-Secreting Cells; Liver; Liver Cirrhosis; Male; Molecular Sequence Data; Peptides; Rats; Rats, Sprague-Dawley; Transforming Growth Factor beta1; Vaccines, Subunit | 2015 |
Inhibition of soluble epoxide hydrolase attenuates hepatic fibrosis and endoplasmic reticulum stress induced by carbon tetrachloride in mice.
Topics: Animals; Carbon Tetrachloride; Collagen; Endoplasmic Reticulum Stress; Enzyme Inhibitors; Epoxide Hydrolases; Hydroxyproline; Liver; Liver Cirrhosis; Mice; Mice, Inbred C57BL; Oxylipins; Phenylurea Compounds; Piperidines | 2015 |
Protective Effect of the Total Saponins from Rosa laevigata Michx Fruit against Carbon Tetrachloride-Induced Liver Fibrosis in Rats.
Topics: Actins; Alanine Transaminase; Animals; Aspartate Aminotransferases; Carbon Tetrachloride; Collagen; Down-Regulation; Fibronectins; Fruit; Glutathione; Hydroxyproline; Liver; Liver Cirrhosis; Male; Malondialdehyde; Matrix Metalloproteinases; Oxidative Stress; Rats; Rats, Sprague-Dawley; Rosa; Saponins; Signal Transduction; Superoxide Dismutase | 2015 |
Geranylgeranylacetone attenuates hepatic fibrosis by increasing the expression of heat shock protein 70.
Topics: Actins; Alanine Transaminase; Animals; Aspartate Aminotransferases; Bilirubin; Carbon Tetrachloride; Disease Models, Animal; Diterpenes; HSP70 Heat-Shock Proteins; Hydroxyproline; Liver; Liver Cirrhosis; Male; Rats; Rats, Sprague-Dawley; Transforming Growth Factor beta1; Up-Regulation | 2015 |
Yiguanjian decoction and its ingredients inhibit angiogenesis in carbon tetrachloride-induced cirrhosis mice.
Topics: Actins; Angiogenesis Inhibitors; Animals; Carbon Tetrachloride; Collagen; Drugs, Chinese Herbal; Hydroxyproline; Hypoxia-Inducible Factor 1, alpha Subunit; Liver Cirrhosis; Liver Cirrhosis, Experimental; Medicine, Chinese Traditional; Mice; Mice, Inbred C57BL; Neovascularization, Pathologic; Random Allocation; Rats, Wistar; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factor Receptor-2 | 2015 |
Hepatoprotective effects of zingerone on carbon tetrachloride- and dimethylnitrosamine-induced liver injuries in rats.
Topics: Alanine Transaminase; Animals; Anti-Inflammatory Agents; Antioxidants; Aspartate Aminotransferases; Biomarkers; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Cytoprotection; Dimethylnitrosamine; Guaiacol; Hep G2 Cells; Hepatic Stellate Cells; Humans; Hydroxyproline; Inflammation Mediators; Lipid Peroxidation; Liver; Liver Cirrhosis, Experimental; Male; Mitogen-Activated Protein Kinases; Oxidative Stress; Rats, Sprague-Dawley; Signal Transduction | 2016 |
Protective effects of seed melon extract on CCl
Topics: Actins; Animals; Antioxidants; Biomarkers; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Citrullus; Cytoprotection; Enzymes; Hydroxyproline; Liver; Liver Cirrhosis; Male; Mice; Necrosis; Oxidative Stress; Phytotherapy; Plant Extracts; Plants, Medicinal; Seeds; Signal Transduction; Silymarin; Transforming Growth Factor beta1 | 2016 |
Automated evaluation of liver fibrosis in thioacetamide, carbon tetrachloride, and bile duct ligation rodent models using second-harmonic generation/two-photon excited fluorescence microscopy.
Topics: Animals; Automation, Laboratory; Bile Ducts; Carbon Tetrachloride; Disease Models, Animal; Hydroxyproline; Ligation; Liver; Liver Cirrhosis; Male; Mice, Inbred BALB C; Mice, Inbred C57BL; Microscopy, Fluorescence, Multiphoton; Rats, Sprague-Dawley; Rats, Wistar; Reproducibility of Results; Sensitivity and Specificity; Species Specificity; Thioacetamide | 2017 |
Optimized Mouse Models for Liver Fibrosis.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP-Binding Cassette Sub-Family B Member 4; Azo Compounds; Biomarkers; Carbon Tetrachloride; Collagen; Disease Models, Animal; Disease Progression; Extracellular Matrix; Gene Expression; Histocytochemistry; Humans; Hydroxyproline; Liver; Liver Cirrhosis; Mice; Mice, Inbred C57BL; Mice, Knockout; Thioacetamide | 2017 |
Preconditioning with melatonin improves therapeutic outcomes of bone marrow-derived mesenchymal stem cells in targeting liver fibrosis induced by CCl4.
Topics: Animals; Bone Marrow Cells; Carbon Tetrachloride; Hydroxyproline; Liver Cirrhosis; Male; Melatonin; Mesenchymal Stem Cell Transplantation; Mesenchymal Stem Cells; Rats, Sprague-Dawley | 2017 |
Protective Effects of Amarogentin against Carbon Tetrachloride-Induced Liver Fibrosis in Mice.
Topics: Actins; Albumins; Animals; Antioxidants; Carbon Tetrachloride; Cell Line; Dose-Response Relationship, Drug; Down-Regulation; Gentiana; Glycosides; Humans; Hydroxyproline; Iridoids; Liver Cirrhosis; Malondialdehyde; Mice; Mice, Inbred C57BL; Nucleotides, Cyclic; Oxidative Stress; Phytotherapy; Plant Extracts; Plant Roots; Swertia; Tissue Distribution | 2017 |
2-Hydroxy-4-methoxy benzoic acid attenuates the carbon tetra chloride-induced hepatotoxicity and its lipid abnormalities in rats via anti-inflammatory and antioxidant mechanism.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Benzoates; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Collagen; Cytokines; Glutathione; Heme Oxygenase-1; Hydroxyproline; Lipid Metabolism; Lipid Peroxidation; Liver; Male; Peroxidase; Rats, Wistar | 2017 |
Renin-angiotensin system inhibition ameliorates CCl
Topics: Actins; Alanine Transaminase; alpha-Fetoproteins; Animals; Carbon Tetrachloride; Gene Expression Regulation; Hydroxyproline; Liver Cirrhosis; Male; Matrix Metalloproteinase 2; Mice; NF-kappa B; Renin-Angiotensin System; Tissue Inhibitor of Metalloproteinase-1; Transforming Growth Factor beta; Tumor Necrosis Factor-alpha | 2018 |
Locostatin Alleviates Liver Fibrosis Induced by Carbon Tetrachloride in Mice.
Topics: Actins; Animals; Carbon Tetrachloride; Cell Movement; Collagen Type I; Collagen Type II; E-Selectin; Hepatic Stellate Cells; Hydroxyproline; Liver Cirrhosis; Male; Matrix Metalloproteinase 13; Matrix Metalloproteinase 2; Mice; Mice, Inbred C57BL; Oxazolidinones; Peroxidase; Phosphatidylethanolamine Binding Protein; Platelet-Derived Growth Factor; RNA, Messenger; Tissue Inhibitor of Metalloproteinase-1; Tissue Inhibitor of Metalloproteinase-2; Transforming Growth Factor beta | 2019 |
Liquiritigenin suppresses the activation of hepatic stellate cells via targeting miR-181b/PTEN axis.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Carbon Tetrachloride; Cell Proliferation; Down-Regulation; Flavanones; Glycyrrhiza; Hepatic Stellate Cells; Humans; Hydroxyproline; Immunohistochemistry; Liver; Liver Cirrhosis; Male; Mice; Mice, Inbred C57BL; MicroRNAs; PTEN Phosphohydrolase | 2020 |
The combination of experimental periodontitis and oral microbiota from periodontitis patients aggravates liver fibrosis in mice.
Topics: Actins; Alanine Transaminase; Animals; Azo Compounds; Carbon Tetrachloride; Hydroxyproline; Liver Cirrhosis; Male; Methylene Blue; Mice; Microbiota; Periodontitis; RNA, Ribosomal, 16S; Transforming Growth Factor beta | 2022 |
Therapeutic Effects of Albumin-Fused BMP7 on 2 Experimental Models of Liver Fibrosis.
Topics: Albumins; Animals; Bone Morphogenetic Protein 7; Carbon Tetrachloride; Hydroxyproline; Liver; Liver Cirrhosis; Mice; Transforming Growth Factor beta1 | 2023 |