Compounds > carbon monoxide

carbon monoxide and tirapazamine

carbon monoxide has been researched along with tirapazamine in 4 studies

Research

Studies (4)

TimeframeStudies, this research(%)All Research%
pre-19901 (25.00)18.7374
1990's2 (50.00)18.2507
2000's0 (0.00)29.6817
2010's1 (25.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Walton, MI; Wolf, CR; Workman, P2
Graham, MA; Hemingway, SA; Riley, RJ; Workman, P1
Dang, J; Li, Y; Liang, Q; Yin, L1

Other Studies

4 other study(ies) available for carbon monoxide and tirapazamine

ArticleYear
The role of cytochrome P450 and cytochrome P450 reductase in the reductive bioactivation of the novel benzotriazine di-N-oxide hypoxic cytotoxin 3-amino-1,2,4-benzotriazine-1,4-dioxide (SR 4233, WIN 59075) by mouse liver.
    Biochemical pharmacology, 1992, Jul-22, Volume: 44, Issue:2

    Topics: Animals; Biotransformation; Carbon Monoxide; Cell Hypoxia; Cell Survival; Cytochrome P-450 Enzyme System; Male; Mice; Mice, Inbred C3H; Microsomes, Liver; NADPH-Ferrihemoprotein Reductase; Phenobarbital; Tirapazamine; Triazines

1992
Molecular enzymology of the reductive bioactivation of hypoxic cell cytotoxins.
    International journal of radiation oncology, biology, physics, 1989, Volume: 16, Issue:4

    Topics: Animals; Antineoplastic Agents; Aziridines; Azirines; Biotransformation; Carbon Monoxide; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Cytosol; Male; Mice; Mice, Inbred C3H; Microsomes, Liver; Nitroimidazoles; Oxidation-Reduction; Radiation-Sensitizing Agents; Tirapazamine; Triazines

1989
Initial characterization of the major mouse cytochrome P450 enzymes involved in the reductive metabolism of the hypoxic cytotoxin 3-amino-1,2,4-benzotriazine-1,4-di-N-oxide (tirapazamine, SR 4233, WIN 59075).
    Biochemical pharmacology, 1993, Mar-09, Volume: 45, Issue:5

    Topics: Animals; Antineoplastic Agents; Benzoflavones; Carbon Monoxide; Cell Hypoxia; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dexamethasone; Male; Metyrapone; Mice; Mice, Inbred BALB C; Microsomes, Liver; Oxidation-Reduction; Oxygen; Tirapazamine; Triazines

1993
Carbon monoxide (CO)-Strengthened cooperative bioreductive anti-tumor therapy via mitochondrial exhaustion and hypoxia induction.
    Biomaterials, 2019, Volume: 209

    Topics: Animals; Carbon Monoxide; Cell Hypoxia; Cell Line, Tumor; Female; Hemoglobins; Mice; Mice, Inbred BALB C; Mitochondria; Oxygen Consumption; Reactive Oxygen Species; Tirapazamine

2019