carbon monoxide has been researched along with phenobarbital in 207 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 194 (93.72) | 18.7374 |
| 1990's | 11 (5.31) | 18.2507 |
| 2000's | 2 (0.97) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Abraham, MH; Acree, WE; Ibrahim, A | 1 |
| Autrup, H; Thurlow, BJ; Warwick, GP | 1 |
| Shigematsu, H; Yamano, S; Yoshimura, H | 1 |
| Iwasaki, K; Kato, R; Sugiura, M | 1 |
| Iwasaki, K; Kato, R; Noguchi, N; Shiraga, T | 1 |
| Kahl, GF; Kahl, R; Kumaki, K; Nebert, DW | 1 |
| Cheng, FW; Dayal, B; Mosbach, EH; Salen, G; Setoguchi, T; Shefer, S; Tint, GS | 1 |
| Kato, R; Sugiura, M | 1 |
| Aronson, I; Ivanetich, KM; Katz, ID | 1 |
| Jonsson, J | 1 |
| Furukawa, T; Karashima, D; Shigematsu, A; Takahashi, S | 1 |
| Evans, JS; Gammans, RE; Sternson, LA; Wade, AE | 1 |
| Deutschmann, G; Mansuy, D; Nastainczyk, W; Ullrich, V; Wolf, CR | 1 |
| Estabrook, RW; Werringloer, J | 1 |
| Dey, AC; Senciall, IR | 1 |
| Iamkovoĭ, VI; Liakhovich, VV; Pospelova, LN; Tsyrlov, IB; Vaĭner, LM | 1 |
| Korzeniowski, D; Levin, W; Ryan, DE; Thomas, PE | 1 |
| Jänig, GR; Pfeil, D; Ruckpaul, K | 1 |
| Krauss, P; Nehls, P; Remmer, H; Synder, R; Witmer, C | 1 |
| Flemming, K; Mönig, H; Mull, RH; Schgaguler, M; Voigt, T | 1 |
| Nambara, T; Numazawa, M; Shirao, R; Soeda, N | 1 |
| Dave, CV; Gurtoo, HL | 1 |
| Beckett, AH; Dajani, RM; Gorrod, JW | 1 |
| Roach, MK | 1 |
| Grudin, R; Moldèus, P; Orrenius, S; Vadi, H | 1 |
| Berman, MC; Ivanetich, KM; Kench, JE | 1 |
| Boose, RB; Kohlhepp, SJ; May, HE; Reed, DJ | 1 |
| Damani, LA; Gorrod, JW | 1 |
| Kiyono, Y; Nambara, T; Numazawa, M; Soeda, N | 1 |
| Billwitz, H; Böhm, S; Butschak, G; Rein, H; Ruckpaul, K; Scheunig, G | 1 |
| Burk, RF; Correia, MA | 1 |
| Gray, RD | 3 |
| Gillesse, T; Hamburg, A; Hanzlik, RP; Shearer, GO | 1 |
| Agosin, M; Capdevila, J; Naquira, C; Paulin, J | 1 |
| Conney, AH; Kuntzman, R; Levin, W; Lu, AY; Ryan, D; West, Sk | 1 |
| Gromova, OA; Lyakhovich, VV; Tsyrlov, IB; Zakharova, NE | 1 |
| Turner, DM | 1 |
| Conney, AH; Cooper, DY; Kuntzman, R; Levin, W; Lu, AY; Rosenthal, O; Schleyer, H | 1 |
| Jones, LS; Kauffman, FC; Marazzo, DP; Thurman, RG | 1 |
| Ioannides, C; Parke, DV; Tong, S | 1 |
| Agosin, M | 1 |
| Koike, M; Matsubara, T; Sugeno, K; Tochino, Y; Touchi, A | 1 |
| Huang, MT; Kawalek, J; Levin, W; Lu, AY; Ryan, D; Thomas, P; West, SB | 1 |
| Altman, FP; Chayen, J; Moore, DS | 1 |
| Kawalek, J; Levin, L; Lu, YH; Ryan, D; West, SB | 1 |
| Cooper, DY; Rosenthal, O; Schleyer, H; Thomas, JH; Vars, HM | 1 |
| Cavallin-Stähl, E; Lundh, B; Mercke, C | 1 |
| Boose, R; May, HE; Reed, DJ | 2 |
| Arcos, JC; Argus, MF; Pastor, KM; Venkatesan, N; Wu, BC | 1 |
| Davydov, DR; Hoa, GH; Knyushko, TV | 1 |
| Hoffmann, P; Pankow, D; Weise, M | 1 |
| Walton, MI; Wolf, CR; Workman, P | 1 |
| Cederbaum, AI; Winters, DK | 1 |
| Cinicola, DP; Esposito, FM; Winek, CL | 1 |
| Gelboin, HV; Jeffrey, AM; Li, MH; Lu, SJ; Park, SS | 1 |
| Gautier, H | 1 |
| Smith, AG; Stewart, FP | 1 |
| Gram, TE; Okine, LK | 1 |
| Di Iorio, EE; Oertle, M; Richter, C; Winterhalter, KH | 1 |
| Kuwahara, S; Mannering, GJ | 1 |
| Inoue, T; Kishi, T; Niwaguchi, T; Suzuki, S; Yasuda, T | 1 |
| Hetnarski, K; Murray, M; Wilkinson, CF | 1 |
| Gangolli, S; Wright, M | 1 |
| Gielen, JE; Goujon, FM; Nebert, DW | 1 |
| Christensen, F | 1 |
| Lehrmann, C; Rummel, W; Ullrich, V | 1 |
| Rösen, P; Stier, A | 2 |
| Tabarelli, S; Uehleke, H | 1 |
| Björkhem, I; Gustafsson, J | 1 |
| Bolt, HM; Kappus, H; Remmer, H | 2 |
| Mazel, P; Shargel, L | 2 |
| Brodie, BB; Davis, DC; Gillette, JR; Jollow, DJ; Mitchell, JR; Potter, WZ | 1 |
| Fujita, T; Mannering, GJ | 1 |
| Gonasun, LM; Kocsis, JJ; Snyder, R; Witmer, C | 1 |
| Gibbons, GF; Mitropoulos, KA | 1 |
| Jacobson, M; Kuntzman, R; Levin, W; Lu, AY; McCay, PB; Poyer, JL | 1 |
| Stawarz, RJ; Stitzel, RE | 1 |
| Neal, RA; Norman, BJ; Poore, RE | 1 |
| Björkhem, I; Danielsson, H | 2 |
| Estabrook, RW; Hrycay, EG | 1 |
| Alvares, AP; Bickers, DR; Kappas, A | 1 |
| Bassir, O; Emerole, GO | 1 |
| Kröber, F; Lange, G; Mathes, S; Mor, G | 2 |
| Mansuy, D; Nastainczyk, W; Ullrich, V | 1 |
| Ernster, L; Orrenius, S | 1 |
| Miyake, Y; Mori, K; Yamano, T | 1 |
| Estabrook, RW; Franklin, MR; Hildebrandt, AG | 1 |
| Mason, HS; Waterman, MR | 1 |
| Conney, AH; Kuntzman, R; Lu, AY; Somogyi, A; West, S | 1 |
| Ballou, DP; Coon, MJ; van der Hoeven, TA; Veeger, C | 1 |
| Illing, HP; Netter, KJ | 1 |
| Ericsson, JL; Ernster, L; Orrenius, S | 1 |
| Neal, RA | 1 |
| Hagihara, B; Ichikawa, Y; Yamano, T | 1 |
| Gillette, JR; Hernandez, PH; Mazel, P | 1 |
| Das, ML; Ernster, L; Orrenius, S | 1 |
| Gaylor, JL; Mason, HS; Miyake, Y | 1 |
| Coon, MJ; Junk, KW; Lu, AY | 1 |
| Ichihara, K; Kusunose, E; Kusunose, M | 1 |
| Gillette, JR | 1 |
| Lisboa, BP; Orrenius, S; von Bahr, C | 1 |
| Prough, RA; Reed, DJ; Wittkop, JA | 2 |
| Cronholm, T; Johansson, G | 1 |
| Lange, G; Thun, KJ | 1 |
| Estabrook, RW; Franklin, MR | 1 |
| Jakobsson, S; Orrenius, S; Thor, H | 1 |
| Johansson, G | 1 |
| Carter, EA; Isselbacher, KJ | 1 |
| Feller, DR; Gillette, JR; Morita, M | 1 |
| Alvares, AP; Kappas, A; Mitani, F; Sassa, S | 1 |
| Garner, JV; Garner, RC; Hanson, RS; Miller, EC; Miller, JA | 1 |
| Mattocks, AR; White, IN | 1 |
| Gnosspelius, Y; Orrenius, S; Thor, H | 1 |
| Van Dyke, RA; Wineman, CG | 1 |
| Balny, C; Debey, P | 1 |
| Kupfer, D; Levin, E | 1 |
| Cooper, DY; Czygan, P; Greim, H; Hutterer, F; Popper, H; Rosenthal, O; Schaffner, F; Trülzsch, D | 1 |
| Frommer, U; Orrenius, S; Staudinger, H; Ullrich, V | 1 |
| Philpot, RM | 1 |
| Berk, PD; Blaschke, TF; Collison, HA; Rodkey, FL; Scharschmidt, BF; Waggoner, JG | 1 |
| Creighton, JM; Roberts, RJ; Winston, JM | 1 |
| Hildebrandt, AG | 1 |
| Grantham, PH; Matsushima, T; Weisburger, EK; Weisburger, JH | 1 |
| Agosin, M; Capdevila, J; Morello, A; Perry, AS | 2 |
| Comai, K; Gaylor, JL | 1 |
| Dybing, E | 1 |
| Berg, A; Gustafsson, JA | 1 |
| Kiese, M; Lenk, W | 2 |
| Gustafsson, JA; Ingelman-Sundberg, M | 1 |
| Day, PA; McLean, AE | 1 |
| Hüthwohl, B; Jonen, HG; Kahl, GF; Kahl, R | 1 |
| Berk, PD; Blaschke, TF; Guyther, JR; Scharschmidt, BF; Vergalla, JM; Waggoner, JG | 1 |
| Debey, P; Douzou, P | 1 |
| Dean, ME; Stock, BH | 1 |
| Anders, MW; Maines, MD; Muller-Eberhard, U | 1 |
| Nichol, AW | 1 |
| Duncan, C; Guest, AD; Lawther, PJ | 1 |
| Levin, W; Lu, AY | 1 |
| Alvares, AP; Conney, AH; Gommi, B; Welch, RM | 1 |
| Hassinen, IE; Ylikahri, RH | 1 |
| Horie, T; Kitada, M; Kitagawa, H | 1 |
| Alvares, A; Conney, AH; Kuntzman, R; Levin, W | 1 |
| Alvares, AP; Kuntzman, R; Levin, W | 1 |
| White, P | 1 |
| Landaw, SA | 1 |
| Estabrook, RW; Hildebrandt, AG; Leibman, KC | 1 |
| Hirata, K; Nakao, K; Sakamoto, Y; Wada, F | 2 |
| Coburn, RF | 1 |
| Daly, JW | 1 |
| Callahan, EW; Landaw, SA; Schmid, R | 1 |
| King, TE; Mason, HS; Oldham, S; Yong, FC | 1 |
| Leibman, KC; Sunderman, FW | 1 |
| Alvares, AP; Levin, W; Schilling, G | 1 |
| Ichikawa, Y; Yamano, T | 1 |
| Aust, SD; Pederson, TC | 1 |
| Jaccarini, A; Jepson, JB | 1 |
| Alvares, AP; Kuntzman, R; Levin, W; Schilling, G | 2 |
| George, WJ; Tephly, TR | 1 |
| Gelboin, HV; Nebert, DW | 1 |
| Conney, AH; Jacobson, M; Kuntzman, R; Levin, W | 1 |
| Mannering, GJ; Sladek, NE | 1 |
| Hlavica, P; Kiese, M | 1 |
| Kuntzman, R; Levin, W | 1 |
| Silverman, DA; Talalay, P | 1 |
| Cong, Z | 1 |
| Johnson, JD; Martinez, CW; Ostrander, CR; Wetmore, DL | 1 |
| Gorrod, JW; Patterson, LH | 1 |
| Bansal, SK; Gurtoo, HL; Love, J | 1 |
| Seidel, SL; Shawver, LK; Shires, TK | 1 |
| Walsh, C; Waxman, DJ | 1 |
| Aasen, AJ; Hansen, CE; Pedersen, JI; Støren, O; Størmer, FC | 1 |
| Cherry, RJ; Gut, J; Kawato, S; Richter, C; Winterhalter, KH | 1 |
| Brittain, T; Costa, AK; Ivanetich, KM | 1 |
| Dean, WL; Gray, RD | 1 |
| de Groot, H; Harnisch, U; Noll, T | 1 |
| Iba, MM; Mannering, GJ; Nerland, DE | 1 |
| Inoue, T; Murata, T; Niwaguchi, T | 1 |
| van der Hoeven, T | 1 |
| Anders, MW; Stevens, JL | 1 |
| Latif, SA; McDermott, MJ; Morris, DJ | 1 |
| Horie, T; Kinoshita, K; Kitada, M; Kitagawa, H; Ohno, T | 1 |
| Cooper, DY; Hamill, S; Rosenthal, O; Schleyer, H | 1 |
| Cumps, J; Dumont, P; Luu-The, V; Vandresse, C | 1 |
| Hollenberg, PF; Koop, DR | 1 |
| Halpert, J; Neal, RA | 1 |
| Advani, SV; Andresen, JW; Bidlack, WR | 1 |
| Anders, MW; Ratnayake, JH; Stevens, JL | 1 |
| Hara, T; Harada, N; Ishii, Y; Kikuichi-Nishimura, N; Koga, N; Oguri, K; Yamada, H; Yoshimura, H | 1 |
| Beaune, P; Doostzadeh, J; el Kahwaji, J; Labbe, G; Leclaire, J; Loeper, J; Pessayre, D; Thal, C; Tinel, M | 1 |
| Bennett, BM; McDonald, BJ | 1 |
| Kotze, AC | 1 |
| Arai, T; Cho, AK; Horie, T; Ishikawa, T; Kumagai, Y; Masubuchi, Y; Narimatsu, S; Suzuki, T; Tsutsui, M; Watanabe, T | 1 |
| Albores, A; Eldirdiri, NI; Ferrara, R; King, LJ; Manno, M; Tolando, R | 1 |
| Archakov, AI; Karuzina, II; Lisitsa, AV; Petushkova, NA; Zgoda, VG | 1 |
3 review(s) available for carbon monoxide and phenobarbital
| Article | Year |
|---|---|
The oxygen sensing characteristics of microsomal enzymes.
Topics: Animals; Carbon Monoxide; Coenzyme A; Cytochrome P-450 Enzyme System; Electron Transport; Enzyme Induction; Ethylmorphine-N-Demethylase; Flavoproteins; Hydrogen Peroxide; Microsomes, Liver; Mixed Function Oxygenases; NADP; Oxidation-Reduction; Oxygen; Oxygen Consumption; Peroxidases; Phenobarbital; Superoxides | 1977 |
Hydroxylations in biosynthesis and metabolism of bile acids.
Topics: Acetates; Animals; Bile Acids and Salts; Biliary Tract Diseases; Carbon Monoxide; Carbon Radioisotopes; Chenodeoxycholic Acid; Cholesterol; Cholic Acids; Cytochrome P-450 Enzyme System; Cytochrome Reductases; Electron Transport; Enzyme Activation; Hydroxylation; Hyperthyroidism; Liver; Magnesium; Microsomes, Liver; Mitochondria, Liver; Mixed Function Oxygenases; NADP; Phenobarbital; Phospholipids; Rats; Taurocholic Acid; Thyroid Hormones; Tritium | 1974 |
The binding of metyrapone to cytochrome P-450 and its inhibitory action on microsomal hepatic mixed function oxidation reactions.
Topics: Animals; Binding Sites; Carbon Monoxide; Cyanides; Cytochrome P-450 Enzyme System; Ethylamines; Hydrogen-Ion Concentration; In Vitro Techniques; Isocitrate Dehydrogenase; Methylation; Metyrapone; Microsomes, Liver; Morphinans; Oxidation-Reduction; Phenobarbital; Proadifen; Pseudomonas; Rats; Spectrum Analysis | 1972 |
2 trial(s) available for carbon monoxide and phenobarbital
| Article | Year |
|---|---|
Heme catabolism during short-term treatment with phenobarbital, diazepam and oxazepam.
Topics: Adult; Bilirubin; Carbon Monoxide; Depression, Chemical; Diazepam; Heme; Hemoglobins; Humans; Male; Oxazepam; Phenobarbital; Stimulation, Chemical; Time Factors | 1975 |
Carbon monoxide and phenobarbitone: a comparison of effects on auditory flutter fusion threshold and critical flicker fusion threshold.
Topics: Adult; Auditory Threshold; Carbon Monoxide; Clinical Trials as Topic; Depression, Chemical; Environmental Exposure; Flicker Fusion; Humans; Male; Middle Aged; Phenobarbital; Placebos; Stimulation, Chemical | 1970 |
202 other study(ies) available for carbon monoxide and phenobarbital
| Article | Year |
|---|---|
Air to lung partition coefficients for volatile organic compounds and blood to lung partition coefficients for volatile organic compounds and drugs.
Topics: Air; Animals; Humans; Lung; Organic Chemicals; Probability; Rats; Tissue Distribution; Volatilization | 2008 |
The effects of the continuous administration of N,N-dimethyl-4-phenylazoaniline (DAB) on the activities and the inducibilities of some drug-metabolizing enzymes in rat liver.
Topics: Animals; Carbon Monoxide; Cerebroside-Sulfatase; Cytochrome P-450 Enzyme System; Glucuronidase; Liver; Lysosomes; Male; Methylcholanthrene; Microsomes, Liver; NADPH-Ferrihemoprotein Reductase; Nitrate Reductases; Oxidoreductases; Oxidoreductases, N-Demethylating; p-Dimethylaminoazobenzene; Phenobarbital; Rats | 1975 |
NADH-dependent O-deethylation of p-nitrophenetole with rabbit liver microsomes.
Topics: Animals; Carbon Monoxide; Cobalt; Copper; Cytochrome P-450 Enzyme System; Cytochromes; Ethyl Ethers; Hydrogen-Ion Concentration; Iron; Kinetics; Male; Mercury; Methylcholanthrene; Microsomes, Liver; NAD; Oxidoreductases; Oxygen Consumption; Partial Pressure; Phenobarbital; Rabbits | 1976 |
Reduction of tertiary amine N-oxides by liver microsomal cytochrome P-450.
Topics: Amines; Aniline Compounds; Animals; Binding, Competitive; Carbon Monoxide; Cytochrome P-450 Enzyme System; Hydrogen-Ion Concentration; Imipramine; Kinetics; Liver; Male; Methylcholanthrene; Microsomes, Liver; Oxides; Oxygen Consumption; Phenobarbital; Rats; Subcellular Fractions | 1976 |
Evidence for the involvement of cytochrome P-450 in reduction of benzo(a)pyrene 4,5-oxide by rat liver microsomes.
Topics: Aging; Animals; Benzopyrenes; Carbon Monoxide; Cytochrome P-450 Enzyme System; Female; Kinetics; Liver; Male; Microsomes, Liver; NADP; Oxides; Phenobarbital; Rats; Sex Factors | 1976 |
Association of the Ah locus with specific changes in metyrapone and ethylisocyanide binding to mouse liver microsomes.
Topics: Animals; Binding Sites; Carbon Monoxide; Cyanides; Cytochrome P-450 Enzyme System; Cytochromes; Dithionite; Enzyme Induction; Genes, Dominant; Hydrogen-Ion Concentration; Methylcholanthrene; Metyrapone; Mice; Microsomes, Liver; Mutation; Oxygenases; Phenobarbital; Protein Binding; Protein Conformation; Spectrophotometry | 1976 |
Cholic acid biosynthesis: conversion of 5beta-cholestane-3alpha,7alpha,12alpha,25-tetrol into 5beta-cholestane-3alpha,7alpha, 12alpha,24beta,25-pentol by human and rat liver microsomes.
Topics: Animals; Carbon Monoxide; Cholic Acids; Gas Chromatography-Mass Spectrometry; Humans; Hydrogen-Ion Concentration; Kinetics; Male; Microsomes, Liver; Phenobarbital; Rats; Species Specificity; Steroid Hydroxylases; Sterols | 1977 |
Reduction of tertiary amine N-oxides by rat liver mitochondria.
Topics: Adenosine Triphosphate; Amines; Aniline Compounds; Animals; Antimycin A; Benzothiazoles; Carbon Monoxide; Citric Acid Cycle; Cyanides; Dicarboxylic Acids; Digitonin; Imipramine; In Vitro Techniques; Male; Mitochondria, Liver; NAD; NADP; Oxidation-Reduction; Oxidoreductases Acting on CH-NH Group Donors; Oxygen; Phenobarbital; Piperazines; Rats; Rotenone; Thiazoles; Tricarboxylic Acids | 1977 |
The interaction of vinyl chloride with rat hepatic microsomal cytochrome P-450 in vitro.
Topics: Animals; Binding Sites; Carbon Monoxide; Cytochrome P-450 Enzyme System; Kinetics; Male; Methylcholanthrene; Microsomes, Liver; NADP; Phenobarbital; Protein Binding; Rats; Spectrophotometry; Vinyl Chloride; Vinyl Compounds | 1977 |
On the aromatic hydroxylation of amphetamine in rat liver microsomes and perfused liver preparations: effects of long-term administration.
Topics: Administration, Oral; Amphetamines; Animals; Carbon Monoxide; Cytochrome P-450 Enzyme System; Desipramine; Fenfluramine; Hydroxylation; Male; Microsomes, Liver; NADP; NADPH-Ferrihemoprotein Reductase; Perfusion; Phenobarbital; Proadifen; Rats; Rats, Inbred Strains; Time Factors | 1977 |
Formaldehyde formation as a metabolite of methoxyflurane.
Topics: Animals; Carbon Monoxide; Cytochrome P-450 Enzyme System; Formaldehyde; Haplorhini; Male; Methoxyflurane; Microsomes, Liver; NADP; Oxygen; Phenobarbital; Rabbits; Rats | 1977 |
Interaction of nitromethane with reduced hepatic microsomal cytochrome P-450.
Topics: Aniline Compounds; Animals; Carbon Monoxide; Cytochrome P-450 Enzyme System; Dithionite; Hydrogen-Ion Concentration; In Vitro Techniques; Kinetics; Male; Methylcholanthrene; Microsomes, Liver; Morphine Derivatives; Nitro Compounds; Oxidation-Reduction; Phenobarbital; Rabbits; Spectrophotometry | 1977 |
The reduction of polyhalogenated methanes by liver microsomal cytochrome P450.
Topics: Animals; Benzopyrenes; Carbon Monoxide; Cytochrome P-450 Enzyme System; Enzyme Induction; Hydrocarbons, Halogenated; In Vitro Techniques; Light; Male; Microsomes, Liver; NADP; Oxidation-Reduction; Oxygen; Phenobarbital; Rats; Spectrophotometry; Spectrophotometry, Infrared; Time Factors | 1977 |
Acidic steroid metabolites: biosynthesis of steroid carboxylic acids by rabbit liver microsomes and the involvement of a cytochrome P450-independent mixed function oxidase system.
Topics: Androstenes; Animals; Carbon Monoxide; Cyanides; Cytochrome P-450 Enzyme System; Desoxycorticosterone; Female; Hydrogen-Ion Concentration; Microsomes, Liver; Mitochondria, Liver; Mixed Function Oxygenases; NAD; NADP; Nitrogen; Oxidoreductases; Phenobarbital; Progesterone; Rabbits | 1978 |
[Cytochrome P-450 catalyzed oxidation of 1-piperidinoanthraquinone].
Topics: Animals; Anthraquinones; Carbon Monoxide; Catalysis; Cytochrome P-450 Enzyme System; Deoxycholic Acid; In Vitro Techniques; Methylcholanthrene; Microsomes, Liver; NAD; NADP; Oxidation-Reduction; Phenobarbital; Piperidines; Rats; Spectrum Analysis | 1979 |
Separation and characterization of highly purified forms of liver microsomal cytochrome P-450 from rats treated with polychlorinated biphenyls, phenobarbital, and 3-methylcholanthrene.
Topics: Animals; Aroclors; Carbon Monoxide; Cytochrome P-450 Enzyme System; Immunodiffusion; Male; Methylcholanthrene; Microsomes, Liver; Molecular Weight; Oxidation-Reduction; Peptide Fragments; Phenobarbital; Polychlorinated Biphenyls; Rats; Spectrophotometry | 1979 |
Enzymatic activities of matrix-bound components of the liver microsomal cytochrome P-450 system.
Topics: Animals; Carbon Monoxide; Cytochrome P-450 Enzyme System; Enzymes, Immobilized; Male; Microsomes, Liver; NADPH-Ferrihemoprotein Reductase; Phenobarbital; Rabbits; Rats; Spectrophotometry | 1979 |
Optical and electron paramagnetic resonance studies of partially purified rabbit liver cytochrome P-450.
Topics: Animals; Carbon Monoxide; Cytochrome P-450 Enzyme System; Cytochromes; Dithionite; Electron Spin Resonance Spectroscopy; Hexobarbital; Methylcholanthrene; Microsomes, Liver; Phenobarbital; Rabbits; Spectrum Analysis | 1975 |
Characterization of microsomal electron transport components from control, phenobarbital- and 3-methylcholanthrene-treated mice. II. Improved resolution and quantitation of major components in ammonium sulfate fractions from total liver microsomes.
Topics: Ammonium Sulfate; Animals; Carbon Monoxide; Chemical Fractionation; Cytochrome P-450 Enzyme System; Cytochromes; Electron Spin Resonance Spectroscopy; Electron Transport; Hemeproteins; In Vitro Techniques; Membrane Proteins; Methylcholanthrene; Mice; Microsomes, Liver; Molecular Weight; NADH, NADPH Oxidoreductases; NADPH-Ferrihemoprotein Reductase; Phenobarbital; Solubility | 1977 |
Properties of enzyme systems involved in the formation of catechol estrogen glutathione conjugates in rat liver microsomes.
Topics: Animals; Carbon Monoxide; Catechols; Estrogens; Glutathione; In Vitro Techniques; Male; Methylcholanthrene; Microsomes, Liver; NAD; Oxygen Consumption; Phenobarbital; Rats; Time Factors | 1978 |
In vitro metabolic conversion of aflatoxins and benzo(alpha)pyrene to nucleic acid-binding metabolites.
Topics: Aflatoxins; Animals; Benzopyrenes; Carbon Monoxide; Cell Fractionation; DNA; Liver; Methylcholanthrene; Micrococcus; Microsomes, Liver; NADP; Nitrogen; Nucleic Acid Denaturation; Phenobarbital; Proadifen; Rats; RNA; RNA, Transfer; Spectrum Analysis; Thymus Gland; Tritium | 1975 |
In vitro hepatic and extra-hepatic reduction of (minus)-nicotine-1'-N-oxide in rats.
Topics: Anaerobiosis; Animals; Carbon Monoxide; Chromatography, Gas; Cyclic N-Oxides; Cytochrome P-450 Enzyme System; Digestive System; Duodenum; Edetic Acid; Flavins; Gastric Mucosa; Ileum; In Vitro Techniques; Intestines; Kidney; Kinetics; Liver; Lung; Male; Microsomes; Microsomes, Liver; Mitochondria, Liver; Myocardium; NADH, NADPH Oxidoreductases; NADP; Nicotine; Oxidation-Reduction; Oxidoreductases; Phenobarbital; Proadifen; Proteins; Rats | 1975 |
Microsomal ethanol oxidation: activity in vitro and in vivo.
Topics: Animals; Azides; Carbon Monoxide; Catalase; Cyanides; Ethanol; Hydrogen Peroxide; Microsomes, Liver; Mixed Function Oxygenases; NADP; Oxidation-Reduction; Phenobarbital; Proadifen; Pyrazoles; Rats | 1975 |
Drug metabolism in isolated rat liver cells.
Topics: Alprenolol; Animals; Biotransformation; Carbon Monoxide; Cells, Cultured; Cytochrome P-450 Enzyme System; Electron Spin Resonance Spectroscopy; Fasting; Glucose; Glucuronates; Imipramine; Lactates; Liver; Methods; Metyrapone; NADP; Oxidation-Reduction; Phenobarbital; Proadifen; Protein Binding; Rats; Rotenone; Spectrum Analysis; Temperature; Tritium | 1975 |
The effects of halothane on hepatic microsomal electron transfer.
Topics: Animals; Carbon Monoxide; Cyanides; Cytochrome P-450 Enzyme System; Cytochrome Reductases; Cytochromes; Electron Transport; Electron Transport Complex IV; Halothane; Male; Microsomes, Liver; NAD; NADP; Oxidation-Reduction; Oxygen Consumption; Phenobarbital; Rats; Stearoyl-CoA Desaturase | 1975 |
Synthesis and identification of products derived from the metabolism of the carcinostatic 1-(2-chloroethyl)-3-(trans-4-methylcyclohexyl)-1-nitrosourea by rat liver microsomes.
Topics: Animals; Carbon Monoxide; Chemical Phenomena; Chemistry; Hydroxylation; In Vitro Techniques; Magnetic Resonance Spectroscopy; Male; Mass Spectrometry; Mice; Microsomes, Liver; Nitrosourea Compounds; Phenobarbital; Rats; Semustine | 1979 |
The effect of various potential inhibitors, activators and inducers on the N-oxidation of 3-substituted pyridines in vitro.
Topics: Animals; Carbon Monoxide; Cricetinae; Cytochrome P-450 Enzyme System; Enzyme Activation; Enzyme Induction; Enzyme Inhibitors; Guinea Pigs; In Vitro Techniques; Male; Methylcholanthrene; Mice; Microsomes, Liver; Oxidation-Reduction; Phenobarbital; Pyridines; Rabbits | 1979 |
Properties of estradiol 2-hydroxylase and 2-hydroxy-3-deoxyestradiol 3-hydroxylase in rat liver.
Topics: Animals; Carbon Monoxide; Cold Temperature; Estradiol; Estrogens; Light; Male; Methylcholanthrene; Microsomes, Liver; Nitrogen; Oxygen; Phenobarbital; Rats; Steroid Hydroxylases | 1979 |
Infrared spectral studies of carbon monoxide complexes of microsomal cytochromes P-450 and P-448.
Topics: Animals; Camphor; Carbon Monoxide; Cytochrome P-450 Enzyme System; Cytochromes; Methylcholanthrene; Microsomes, Liver; Phenobarbital; Protein Binding; Rabbits; Rats; Spectrophotometry, Infrared | 1979 |
Accelerated hepatic haem catabolism in the selenium-deficient rat.
Topics: Animals; Carbon Monoxide; Cytochrome P-450 Enzyme System; Heme; Liver; Male; Microsomes, Liver; Mixed Function Oxygenases; Phenobarbital; Porphyrins; Proteins; Rats; Selenium | 1977 |
Kinetics of CO binding to and dissociation from microsomal cytochrome P-450 induced by phenobarbital in rat liver.
Topics: Animals; Carbon Monoxide; Cytochrome P-450 Enzyme System; Kinetics; Male; Mathematics; Microsomes, Liver; Phenobarbital; Protein Binding; Rats | 1978 |
Metabolism in vitro of para-substituted styrenes. Kinetic observations of substituent effects.
Topics: Animals; Carbon Monoxide; Cytochrome P-450 Enzyme System; Enzyme Induction; In Vitro Techniques; Kinetics; Male; Microsomes, Liver; Phenobarbital; Rats; Styrenes | 1978 |
Cytochrome P-450 and drug metabolism in Trypanosoma cruzi: effects of phenobarbital.
Topics: Aminopyrine; Aniline Compounds; Animals; Anisoles; Carbon Monoxide; Cytochrome P-450 Enzyme System; Metyrapone; Microsomes; Mixed Function Oxygenases; Oxidoreductases, O-Demethylating; Phenobarbital; Proadifen; Ribosomes; Trypanosoma cruzi | 1976 |
Partial purification and separation of multiple forms of cytochrome. P-450 and cytochrome P-448 from rat liver microsomes.
Topics: Animals; Benzopyrenes; Benzphetamine; Carbon Monoxide; Chromatography, DEAE-Cellulose; Cytochrome P-450 Enzyme System; Cytochromes; Epoxide Hydrolases; Ethane; Lipids; Male; Methylcholanthrene; Microsomes, Liver; Multienzyme Complexes; NADPH-Ferrihemoprotein Reductase; Naphthalenes; Nitriles; Oxidation-Reduction; Phenobarbital; Phosphatidylcholines; Rats; Spectrum Analysis; Surface-Active Agents | 1975 |
Possible mechanism of induction of liver microsomal monooxygenases by phenobarbital.
Topics: Aminopyrine N-Demethylase; Aniline Hydroxylase; Animals; Binding Sites; Carbon Monoxide; Cytochrome P-450 Enzyme System; Cytochromes; Enzyme Induction; Kinetics; Male; Methylcholanthrene; Microsomes, Liver; NADH, NADPH Oxidoreductases; NADPH-Ferrihemoprotein Reductase; Oxygenases; Phenobarbital; Protein Binding; Rats; Spectrophotometry | 1976 |
The effects of some tobacco smoke constituents on foreign compound metabolism in the cat and the rat.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Atmosphere; Carbon Monoxide; Catheterization; Cats; Cotinine; Female; Femoral Vein; In Vitro Techniques; Injections, Subcutaneous; Kidney; Lung; Male; Methylcholanthrene; Microsomes; Microsomes, Liver; Nicotine; Pharmaceutical Preparations; Phenobarbital; Rats; Time Factors | 1977 |
Inhibition by CO of hepatic benzo[a]pyrene hydroxylation and its reversal by monochromatic light.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Benzopyrene Hydroxylase; Carbon Monoxide; Kinetics; Light; Male; Methylcholanthrene; Microsomes, Liver; Phenobarbital; Rats; Spectrophotometry | 1977 |
The continuous kinetic determination of p-nitroanisole O-demethylation in hemoglobin-free perfused rat liver.
Topics: Animals; Anisoles; Carbon Monoxide; Dealkylation; Female; Glucose; Glucuronates; Hemoglobins; In Vitro Techniques; Kinetics; Lactates; Liver; Microsomes, Liver; Nitroanisole O-Demethylase; Nitrophenols; Oxygen Consumption; Perfusion; Phenobarbital; Rats; Sulfates; Time Factors | 1977 |
Possible pitfalls of the biphenyl test for chemical carcinogens [proceedings].
Topics: Animals; Biphenyl Compounds; Carbon Monoxide; Dioxoles; Male; Microsomes, Liver; Mixed Function Oxygenases; Phenobarbital; Rats; Safrole; Spectrometry, Fluorescence | 1977 |
Insect cytochrome P-450.
Topics: Animals; Binding Sites; Carbon Monoxide; Cytochrome P-450 Enzyme System; Houseflies; Membranes; Microsomes; Naphthalenes; Phenobarbital; Proadifen; Protein Binding; Spectrophotometry; Subcellular Fractions | 1976 |
Quantitative determination of cytochrome P-450 in rat liver homogenate.
Topics: Aniline Hydroxylase; Animals; Carbon Monoxide; Cytochrome P-450 Enzyme System; Cytochromes; Dithionite; Hemoglobins; Indicators and Reagents; Liver; Male; Methylcholanthrene; Phenobarbital; Protein Binding; Rats; Spectrophotometry | 1976 |
Multiplicity of liver microsomal cytochrome P-450: separation, purification and characterization.
Topics: Animals; Carbon Monoxide; Cytochrome P-450 Enzyme System; Methylcholanthrene; Mice; Microsomes, Liver; Phenobarbital; Protein Binding; Rabbits; Rats; Species Specificity | 1976 |
The direct measurement of cytochrome P450 in unfixed tissue sections.
Topics: Animals; Carbon Monoxide; Cytochrome P-450 Enzyme System; Dithionite; Frozen Sections; Male; Methods; Nitrogen; Phenobarbital; Rats; Spectrophotometry | 1975 |
Highly purified cytochrome P-448 and P=450 from rat liver microsomes.
Topics: Animals; Benzopyrenes; Benzphetamine; Carbon Monoxide; Chromatography, DEAE-Cellulose; Chromatography, Ion Exchange; Cytochrome P-450 Enzyme System; Cytochromes; Enzyme Induction; Methylcholanthrene; Microsomes, Liver; Molecular Weight; Oxidation-Reduction; Phenobarbital; Rats; Spectrophotometry | 1975 |
Comparison of the induction course, biophysical chemical interactions and photochemical action spectra of phenobarbital and 3-methylcholanthrene induce hepatic microsomal P-450.
Topics: Aniline Compounds; Animals; Biotransformation; Body Weight; Carbon Monoxide; Codeine; Cytochrome P-450 Enzyme System; Enzyme Induction; Hexobarbital; Male; Methylcholanthrene; Metyrapone; Microsomes, Liver; Mixed Function Oxygenases; Oxidation-Reduction; Phenobarbital; Photochemistry; Polycyclic Compounds; Proadifen; Rats; Spectrum Analysis; Time Factors | 1975 |
Microsomal monooxygenation of the carcinostatic 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea. Synthesis and identification of cis and trans monohydroxylated products.
Topics: Animals; Antineoplastic Agents; Carbon Monoxide; Hydroxylation; Lomustine; Male; Methylcholanthrene; Microsomes, Liver; Nitrosourea Compounds; Oxidation-Reduction; Phenobarbital; Rats; Stereoisomerism | 1975 |
Dimethylnitrosamine-demethylase: absence of increased enzyme catabolism and multiplicity of effector sites in repression. Hemoprotein involvement.
Topics: Animals; Carbon Monoxide; Caseins; Cytochrome P-450 Enzyme System; Dietary Proteins; Dimethylnitrosamine; Enzyme Repression; Hemeproteins; Kinetics; Male; Methylcholanthrene; Microsomes, Liver; Nitrosamines; Oxidoreductases, N-Demethylating; Phenobarbital; Rats | 1976 |
High pressure induced inactivation of ferrous cytochrome P-450 LM2 (IIB4) CO complex: evidence for the presence of two conformers in the oligomer.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Carbon Monoxide; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Liposomes; Liver; Phenobarbital; Pressure; Protein Conformation; Proteolipids; Rabbits; Spectrophotometry; Steroid Hydroxylases; Thermodynamics | 1992 |
Effect of isoniazid or phenobarbital pretreatment on the metabolism of dihalomethanes to carbon monoxide.
Topics: Animals; Carbon Monoxide; Carboxyhemoglobin; Hydrocarbons, Brominated; Hydrocarbons, Halogenated; Isoniazid; Male; Methylene Chloride; Phenobarbital; Rats; Rats, Wistar | 1992 |
The role of cytochrome P450 and cytochrome P450 reductase in the reductive bioactivation of the novel benzotriazine di-N-oxide hypoxic cytotoxin 3-amino-1,2,4-benzotriazine-1,4-dioxide (SR 4233, WIN 59075) by mouse liver.
Topics: Animals; Biotransformation; Carbon Monoxide; Cell Hypoxia; Cell Survival; Cytochrome P-450 Enzyme System; Male; Mice; Mice, Inbred C3H; Microsomes, Liver; NADPH-Ferrihemoprotein Reductase; Phenobarbital; Tirapazamine; Triazines | 1992 |
Oxidation of glycerol to formaldehyde by rat liver microsomes. Effects of cytochrome P-450 inducing agents.
Topics: Acetone; Aldehyde Oxidoreductases; Animals; Carbon Monoxide; Cytochrome P-450 Enzyme System; Enzyme Induction; Ethanol; Fomepizole; Formaldehyde; Glycerol; Isoenzymes; Kinetics; Male; Methylcholanthrene; Microsomes, Liver; NAD; Oxidation-Reduction; Phenobarbital; Pyrazoles; Rats; Rats, Inbred Strains | 1990 |
The stability of several compounds in formalin fixed tissues and formalin-blood solutions.
Topics: Carbon Monoxide; Carboxyhemoglobin; Cyanides; Desipramine; Diazepam; Drug Stability; Embalming; Fixatives; Formaldehyde; Humans; Liver; Phenobarbital; Phenytoin; Postmortem Changes | 1990 |
Metabolism of fusarin C by rat liver microsomes. Role of esterase and cytochrome P-450 enzymes with respect to the mutagenicity of fusarin C in Salmonella typhimurium.
Topics: Aflatoxin B1; Aflatoxins; Animals; Antibodies, Monoclonal; Biotransformation; Carbon Monoxide; Cytochrome P-450 Enzyme System; Esterases; Isoflurophate; Microsomes, Liver; Mutagenicity Tests; Phenobarbital; Polyenes; Rats; Salmonella typhimurium | 1989 |
Effects of chronic administration of phenobarbital in low doses on control of breathing in the cat.
Topics: Animals; Behavior, Animal; Carbon Dioxide; Carbon Monoxide; Cats; Drug Administration Schedule; Oxygen; Phenobarbital; Respiration; Tidal Volume | 1986 |
Metabolism of the "mixed" cytochrome P-450 inducer hexachlorobenzene by rat liver microsomes.
Topics: Acetylcysteine; Aroclors; Carbon Monoxide; Chlorobenzenes; Chlorodiphenyl (54% Chlorine); Cytochrome P-450 Enzyme System; Ellipticines; Enzyme Induction; Female; Gas Chromatography-Mass Spectrometry; Glutathione; Hexachlorobenzene; Male; Methylcholanthrene; Metyrapone; Microsomes, Liver; Molecular Weight; NADP; Pentachlorophenol; Phenobarbital; Polychlorinated Dibenzodioxins; Proadifen; Safrole | 1986 |
In vitro studies on the metabolism and covalent binding of [14C]1,1-dichloroethylene by mouse liver, kidney and lung.
Topics: Animals; Benzoflavones; beta-Naphthoflavone; Carbon Monoxide; Cytochrome P-450 Enzyme System; Dichloroethylenes; Enzyme Induction; Glutathione; Hot Temperature; Hydrocarbons, Chlorinated; In Vitro Techniques; Kidney; Liver; Lung; Methylcholanthrene; Mice; Mice, Inbred C57BL; NADP; Phenobarbital; Piperonyl Butoxide; Pregnenolone Carbonitrile; Proadifen; Subcellular Fractions | 1986 |
Kinetics of carbon monoxide binding to phenobarbital-induced cytochrome P-450 from rat liver microsomes: a simple bimolecular process.
Topics: Animals; Carbon Monoxide; Cytochrome P-450 Enzyme System; Electrophoresis, Polyacrylamide Gel; Enzyme Induction; Male; Microsomes, Liver; Phenobarbital; Photolysis; Rats; Rats, Inbred Strains | 1985 |
Evidence for a predominantly NADH-dependent O-dealkylating system in rat hepatic microsomes.
Topics: Animals; Antibodies; Benzoflavones; Carbon Monoxide; Cobalt; Cyanides; Cytochrome b Group; Cytochrome P-450 Enzyme System; Cytochrome Reductases; Cytochrome-B(5) Reductase; Cytochromes b5; Dealkylation; Electron Transport; Ethylmorphine; In Vitro Techniques; Linoleic Acids; Lipid Peroxides; Male; Manganese; Methylcholanthrene; Microsomes, Liver; NAD; NADP; NADPH-Ferrihemoprotein Reductase; Nitrobenzenes; Oxygen; Partial Pressure; Phenobarbital; Proadifen; Rats | 1985 |
The metabolism of 1-phenyl-2-(N-methyl-N-furfurylamino)propane (furfenorex) in the rat in vivo and in vitro.
Topics: Animals; Appetite Depressants; Biotransformation; Carbon Monoxide; Chromatography, Gas; Chromatography, Thin Layer; Furans; In Vitro Techniques; Male; Metyrapone; Microsomes, Liver; NADP; Oxygen; Phenobarbital; Proadifen; Rats; Rats, Inbred Strains; Spectrophotometry | 1986 |
Selective inhibitory interactions of alkoxymethylenedioxybenzenes towards mono-oxygenase activity in rat-hepatic microsomes.
Topics: Aminopyrine N-Demethylase; Animals; Benzoflavones; Benzopyrene Hydroxylase; beta-Naphthoflavone; Carbon Monoxide; Cytochrome P-450 CYP1A1; Cytochrome P-450 Enzyme System; Dioxoles; Enzyme Induction; Isoenzymes; Male; Microsomes, Liver; Mixed Function Oxygenases; Oxidoreductases; Oxygenases; Phenobarbital; Rats; Rats, Inbred Strains; Structure-Activity Relationship | 1985 |
The histochemical demonstration of aniline hydroxylase activity in rat liver.
Topics: Acetone; Aniline Compounds; Animals; Carbon Monoxide; Cyanides; Diazonium Compounds; Ethanol; Female; Formaldehyde; Histocytochemistry; Male; Methylcholanthrene; Microsomes, Liver; Mixed Function Oxygenases; Nitrogen; Phenobarbital; Phenols; Rats; Staining and Labeling; Time Factors | 1971 |
Genetic regulation of aryl hydrocarbon hydroxylase induction. II. Simple Mendelian expression in mouse tissues in vivo.
Topics: Aging; Animals; Benzopyrenes; Carbon Monoxide; Crosses, Genetic; Cytochromes; Enzyme Induction; Female; Genotype; Hydrogen-Ion Concentration; Kidney; Liver; Male; Methylcholanthrene; Mice; Mice, Inbred Strains; Microsomes; Microsomes, Liver; Mixed Function Oxygenases; Molecular Biology; Oxygenases; Phenobarbital; Phenotype; Polycyclic Compounds; Pregnancy | 1972 |
Metabolism of dicoumarol by liver microsomes from untreated and phenobarbital treated rats.
Topics: Animals; Atmosphere; Carbon Monoxide; Chromatography, Paper; Chromatography, Thin Layer; Cytochrome P-450 Enzyme System; Dicumarol; Male; Microsomes, Liver; Mitochondria, Liver; NAD; NADP; Phenobarbital; Proteins; Rats; Rats, Inbred Strains; Time Factors | 1972 |
Phenobarbital inducible drug monooxygenase activity in the small intestine of mice.
Topics: Animals; Carbon Monoxide; Coumarins; Cytochrome P-450 Enzyme System; Dealkylation; Enzyme Activation; Enzyme Induction; Female; Fluorescence; Indophenol; Jejunum; Light; Liver; Mice; Microsomes; Monoamine Oxidase; NADP; Oxidoreductases; Phenobarbital; Stimulation, Chemical | 1973 |
Kinetics of CO and O 2 complexes of rabbit liver microsomal cytochrome P 450 .
Topics: Animals; Carbon Monoxide; Cytochrome P-450 Enzyme System; Hexobarbital; In Vitro Techniques; Kinetics; Microsomes, Liver; NADP; Oxygen Consumption; Phenobarbital; Photolysis; Protein Binding; Rabbits; Time Factors | 1973 |
N-hydroxylation of 4,4'-diaminodiphenylsulphone (Dapsone) by liver microsomes, and in dogs and humans.
Topics: Animals; Carbon Monoxide; Dapsone; Dogs; Erythrocytes; Female; Hemoglobins; Humans; Hydrogen-Ion Concentration; Hydroxylation; Male; Methemoglobin; Metyrapone; Microsomes, Liver; NADP; Oxidation-Reduction; Oxygen; Phenobarbital; Proteins; Rabbits; Time Factors | 1973 |
Omega-hydroxylation of steriod side-chain in biosynthesis of bile acids.
Topics: Animals; Bile Acids and Salts; Carbon Monoxide; Chenodeoxycholic Acid; Cholestanes; Cholestenes; Cholesterol; Hydroxylation; Male; Microsomes, Liver; Mitochondria, Liver; NAD; NADP; Phenobarbital; Rats; Starvation; Steroid Hydroxylases | 1973 |
Irreversible protein binding of metabolites of ethynylestradiol in vivo and in vitro.
Topics: Animals; Binding Sites; Carbon Monoxide; Cattle; Charcoal; Chromatography, Gel; Chromatography, Ion Exchange; Endoplasmic Reticulum; Estradiol; Ethinyl Estradiol; Female; Hydroxylation; Male; Microsomes, Liver; NADP; Peptide Fragments; Phenobarbital; Proadifen; Protein Binding; Proteins; Rats; Serum Albumin, Bovine; Time Factors; Tritium; Trypsin | 1973 |
Effect of riboflavin deficiency on phenobarbital and 3-methylcholanthrene induction of microsomal drug-metabolizing enzymes of the rat.
Topics: Aminopyrine N-Demethylase; Animals; Azo Compounds; Benzopyrenes; Carbon Monoxide; Cytochrome P-450 Enzyme System; Cytochrome Reductases; Diet; Enzyme Induction; In Vitro Techniques; Kinetics; Male; Methylcholanthrene; Microsomes, Liver; Mixed Function Oxygenases; NADP; Nitrogen; Oxidoreductases; Phenobarbital; Rats; Riboflavin Deficiency | 1973 |
Acetaminophen-induced hepatic necrosis. 3. Cytochrome P-450-mediated covalent binding in vitro.
Topics: Acetaminophen; Animals; Caffeine; Carbon Monoxide; Carbon Radioisotopes; Chemical and Drug Induced Liver Injury; Cobalt; Cyanides; Cytochrome P-450 Enzyme System; Fluorenes; In Vitro Techniques; Kinetics; Male; Methylcholanthrene; Microsomes, Liver; NADP; Necrosis; Phenobarbital; Piperonyl Butoxide; Protein Binding; Rats; Time Factors; Tritium | 1973 |
Electron transport components of hepatic microsomes. Solubilization, resolution, and recombination to reconstitute aniline hydroxylase activity.
Topics: Aminopyrine; Aniline Compounds; Animals; Carbon Monoxide; Chloromercuribenzoates; Cytochrome P-450 Enzyme System; Cytochrome Reductases; Cytochromes; Electron Transport; Male; Methylcholanthrene; Microsomes, Liver; Mixed Function Oxygenases; Morphinans; NAD; NADP; Oxidation-Reduction; Phenobarbital; Rats; Solubility; Structure-Activity Relationship; Vitamin K | 1973 |
Benzene metabolism in mouse liver microsomes.
Topics: Animals; Benzene; Carbon Monoxide; Carbon Radioisotopes; Cytochrome P-450 Enzyme System; Hydroxylation; In Vitro Techniques; Kinetics; Male; Mice; Mice, Inbred ICR; Microsomes, Liver; NADP; Oxidoreductases; Phenobarbital; Tritium | 1973 |
The rôle of cytochrome P-450 in cholesterol biosynthesis.
Topics: Adenosine Triphosphate; Animals; Carbon Monoxide; Carbon Radioisotopes; Cholesterol; Cytochrome P-450 Enzyme System; Lanosterol; Light; Male; Microsomes, Liver; NADP; Nitrogen; Oxygen; Phenobarbital; Rats | 1973 |
Lipid peroxidation and the degradation of cytochrome P-450 heme.
Topics: Aminopyrine; Animals; Benzopyrenes; Benzphetamine; Carbon Monoxide; Chromatography, Paper; Chromatography, Thin Layer; Cytochrome P-450 Enzyme System; Levulinic Acids; Lipid Metabolism; Male; Methylcholanthrene; Microsomes, Liver; NADP; Oxidation-Reduction; Pentobarbital; Peroxidases; Phenobarbital; Protein Binding; Rats; Secobarbital; Spectrophotometry; Time Factors; Tritium | 1973 |
Studies on the metabolism of ethynylestradiol in vitro and in vivo: the significance of 2-hydroxylation and the formation of polar products.
Topics: Animals; Carbon Monoxide; Chromatography; Chromatography, Thin Layer; Estradiol; Estrone; Ethinyl Estradiol; Glutathione; Hydroxylation; Male; Microsomes, Liver; NADP; Oxidation-Reduction; Phenobarbital; Proadifen; Rats; Silicon Dioxide; Spectrophotometry, Ultraviolet; Tritium | 1973 |
Hydroxylation of the carcinostatic 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea (CCNU) by rat liver microsomes.
Topics: Animals; Antineoplastic Agents; Carbon Monoxide; Chromatography, Ion Exchange; Cyclohexanes; Hydroxylation; Kinetics; Male; Mass Spectrometry; Microsomes, Liver; NADP; Nitrosourea Compounds; Oxidation-Reduction; Oxygen; Phenobarbital; Rats; Spectrophotometry; Spectrophotometry, Ultraviolet; Time Factors | 1974 |
Factors influencing the microsomal metabolism of 3H-reserpine.
Topics: Animals; Benzoates; Biotransformation; Carbon Monoxide; Cats; Chromatography, Thin Layer; Depression, Chemical; Dogs; Enzyme Induction; Female; Formaldehyde; Guinea Pigs; Hydrogen-Ion Concentration; Hydrolysis; Liver; Male; Methylcholanthrene; Microsomes, Liver; NAD; NADH, NADPH Oxidoreductases; NADP; Phenobarbital; Proadifen; Rats; Reserpine; Stimulation, Chemical; Temperature | 1974 |
Studies of the binding of sulfur released in the mixed-function oxidase-catalyzed metabolism of diethyl p-nitrophenyl phosphorothionate(parathion) to diethyl p-nitrophenyl phosphate (paraoxon).
Topics: Animals; Benzphetamine; Carbon Monoxide; Carbon Radioisotopes; Cytochrome P-450 Enzyme System; Dealkylation; Esterases; In Vitro Techniques; Kinetics; Male; Methylcholanthrene; Microsomes, Liver; NADP; Oxidoreductases; Paraoxon; Parathion; Phenobarbital; Solvents; Sulfur; Sulfur Radioisotopes | 1974 |
The effect of extra bound cytochrome b-5 on cytochrome P-450-dependent enzyme activities in liver microsomes.
Topics: Anaerobiosis; Animals; Benzphetamine; Carbon Monoxide; Cytochrome P-450 Enzyme System; Cytochrome Reductases; Cytochromes; Kinetics; Male; Microsomes, Liver; NADH, NADPH Oxidoreductases; NADP; Oxidation-Reduction; Oxidoreductases, N-Demethylating; Peroxidases; Phenobarbital; Rabbits; Spectrophotometry; Spectrophotometry, Ultraviolet; Time Factors; Ultracentrifugation | 1974 |
Polychlorinated biphenyls: a new type of inducer of cytochrome P-448 in the liver.
Topics: Animals; Benzopyrenes; Carbon Monoxide; Cytochrome P-450 Enzyme System; Cytochromes; Dactinomycin; Enzyme Induction; Ligands; Male; Methylcholanthrene; Microsomes, Liver; Mixed Function Oxygenases; Morphinans; Nitriles; Oxidoreductases, N-Demethylating; Phenobarbital; Polychlorinated Biphenyls; Rats; Spectrophotometry; Stimulation, Chemical | 1973 |
Metabolism of palmotoxins B0 and G0 in vitro.
Topics: Aflatoxins; Animals; Aspergillus flavus; Carbon Monoxide; Chromatography, Thin Layer; Cytochrome P-450 Enzyme System; Enzyme Induction; Glucuronates; Hydrogen-Ion Concentration; Hydroxylation; In Vitro Techniques; Liver; Male; Microsomes, Liver; Mixed Function Oxygenases; Mycotoxins; Oxidoreductases, N-Demethylating; Phenobarbital; Rats; Spectrometry, Fluorescence; Spectrophotometry, Ultraviolet; Subcellular Fractions | 1974 |
[Change in the affinity of isolated liver microsomes for aniline, N-ethylaniline, oxygen, ethyl isocyanide and carbon monoxide by the treatment of young rabbits with phenobarbital].
Topics: Aniline Compounds; Animals; Carbon Monoxide; Cyanides; Enzyme Induction; Liver; Microsomes; Mixed Function Oxygenases; Oxygen; Phenobarbital; Rabbits; Stimulation, Chemical | 1968 |
[Qualitative changes in liver microsomes of phenobarbital-treated rabbits. Changes in spectral dissociation constants (Ks) of aniline and N-ethylaniline, in the apparent Michaelis constants (Km) for hydroxylation of these substrates, and in affinity of th
Topics: Aniline Compounds; Animals; Carbon Monoxide; Cyanides; Enzyme Induction; Kinetics; Microsomes, Liver; Oxygen; Phenobarbital; Rabbits | 1970 |
Proceedings: Kinetics of the binding of carbon monoxide and oxygen to microsomal cytochrome P450 and the influence of substrates.
Topics: Animals; Binding Sites; Carbon Monoxide; Carbon Tetrachloride; Cytochrome P-450 Enzyme System; Dose-Response Relationship, Drug; Halothane; Hexobarbital; In Vitro Techniques; Kinetics; Ligands; Metyrapone; Microsomes, Liver; Oxygen Consumption; Phenobarbital; Photolysis; Rats; Spectrophotometry; Temperature; Tetrachloroethylene; Trichloroethylene | 1974 |
The mechanism of halothane binding to microsomal cytochrome P450.
Topics: Animals; Azo Compounds; Benzopyrenes; Carbon Monoxide; Cytochrome P-450 Enzyme System; Dithionite; Ethylamines; Halothane; Hydrazines; Ligands; Male; Microsomes, Liver; Phenobarbital; Protein Binding; Rats; Spectrophotometry | 1974 |
Phenobarbital-induced synthesis of the oxidative demethylating enzymes of rat liver microsomes.
Topics: Adenosine Triphosphatases; Animals; Carbon Monoxide; Cytochromes; Glucose-6-Phosphatase; In Vitro Techniques; Liver; Microsomes; Oxidoreductases; Phenobarbital; Pigments, Biological; Rats | 1964 |
A study on some spectral properties of P-450 in a submicrosomal particle.
Topics: Animals; Carbon Monoxide; Chemical Phenomena; Chemistry; Cyanides; Cytochromes; Electron Spin Resonance Spectroscopy; Heme; Liver; Microsomes; Nitric Oxide; Oxidation-Reduction; Phenobarbital; Proteins; Rabbits; Spectrophotometry | 1969 |
Factors influencing the inhibitory effect of carbon monoxide on cytochrome P-450-catalyzed mixed function oxidation reactions.
Topics: Animals; Anisoles; Binding Sites; Carbon Monoxide; Cytochromes; Electron Transport; Electron Transport Complex IV; In Vitro Techniques; Methylation; Metyrapone; Microsomes, Liver; Morphine; Nitroso Compounds; Oxidation-Reduction; Phenobarbital; Rats | 1970 |
Redox properties of liver cytochrome P-450.
Topics: Anaerobiosis; Animals; Benzyl Compounds; Carbon Monoxide; Coloring Agents; Cytochromes; Electron Spin Resonance Spectroscopy; Indicators and Reagents; Mathematics; Microsomes, Liver; Oxidation-Reduction; Paraquat; Phenobarbital; Potentiometry; Pyridinium Compounds; Rabbits; Spectrophotometry | 1972 |
Pregnenolone-16 -carbonitrile: a new type of inducer of drug-metabolizing enzymes.
Topics: Aminopyrine N-Demethylase; Animals; Benzopyrenes; Carbon Monoxide; Cyanides; Cytochrome c Group; Cytochrome P-450 Enzyme System; Enzyme Induction; Female; Liver; Methylcholanthrene; Microsomes, Liver; Mixed Function Oxygenases; Morphinans; Nitriles; Organ Size; Oxidoreductases; Oxidoreductases, N-Demethylating; Phenobarbital; Pregnenolone; Rats; Spectrophotometry | 1972 |
Properties of partially purified liver microsomal cytochrome P-450: acceptance of two electrons during anaerobic titration.
Topics: Anaerobiosis; Animals; Binding Sites; Carbon Monoxide; Copper; Cytochrome c Group; Cytochrome P-450 Enzyme System; Cytochrome Reductases; Cytochromes; Electron Transport; Flavin Mononucleotide; Flavin-Adenine Dinucleotide; Iron; Microsomes, Liver; Oxidation-Reduction; Phenobarbital; Protein Binding; Rabbits; Spectrophotometry; Spectrophotometry, Atomic; Spectrophotometry, Ultraviolet; Sulfites; Time Factors | 1974 |
Kinetic experiments on the synergistic effect of NADH on microsomal drug oxidation.
Topics: Aniline Compounds; Animals; Anisoles; Carbon Monoxide; Chloromercuribenzoates; Drug Synergism; Hexobarbital; Male; Metyrapone; Microsomes, Liver; Mixed Function Oxygenases; NAD; Nitro Compounds; Oxidation-Reduction; Oxygen Consumption; Pharmaceutical Preparations; Pharmacology; Phenobarbital; Phenols; Proadifen; Pyridines; Rats; Spectrophotometry | 1974 |
Phenobarbital-induced synthesis of the microsomal drug-metabolizing enzyme system and its relationship to the proliferation of endoplasmic membranes. A morphological and biochemical study.
Topics: Aminopyrine; Animals; Carbon Monoxide; Codeine; Dactinomycin; Endoplasmic Reticulum; In Vitro Techniques; Liver; Microscopy, Electron; Microsomes; NADP; Nitrosamines; Oxidoreductases; Phenobarbital; Pigments, Biological; Puromycin; Rats; Thyroidectomy; Triiodothyronine | 1965 |
Studies on the metabolism of diethyl 4-nitrophenyl phosphorothionate (parathion) in vitro.
Topics: Animals; Benzopyrenes; Carbon Monoxide; Chromatography, Thin Layer; Enzymes; Female; Guinea Pigs; In Vitro Techniques; Liver; Male; Mice; Microsomes; NADP; Nitrogen; Nitrophenols; Oxygen; Parathion; Phenobarbital; Phosphates; Phosphorus Isotopes; Rats | 1967 |
Magnetic and spectrophotometric properties of the microsomal carbon monoxide binding pigment.
Topics: Animals; Carbon Monoxide; Chlordan; Coloring Agents; Cytochromes; DDT; Diphenhydramine; Electron Spin Resonance Spectroscopy; Fasting; Ferrocyanides; Hydrogen-Ion Concentration; Liver; Microsomes; NAD; NADP; Oxygen; Phenobarbital; Phenytoin; Pigments, Biological; Rabbits; Rats; Spectrophotometry | 1967 |
Studies on the mechanism of action of mammalian hepatic azoreductase. II. The effects of phenobarbital and 3-methylcholanthrene on carbon monoxide sensitive and insensitive azoreductase activities.
Topics: Animals; Azo Compounds; Carbon Monoxide; Cytochromes; Female; Lipase; Liver; Methylcholanthrene; Microsomes; NADP; Organ Size; Oxidoreductases; Phenobarbital; Rats; Tetrazolium Salts | 1967 |
On the fatty acid and hydrocarbon hydroxylation in rat liver microsomes.
Topics: Alkanes; Aminopyrine; Animals; Carbon Monoxide; Cytochromes; Depression, Chemical; Fatty Acids; Fluorometry; Liver; Male; Microsomes; NADP; Oxidation-Reduction; Oxidoreductases; Phenobarbital; Pigments, Biological; Rats; Stimulation, Chemical; Testosterone | 1968 |
Properties of a submicrosomal particle containing P-450 and flavoprotein.
Topics: Adrenal Glands; Animals; Carbon Monoxide; Cattle; Cyanides; Cytochromes; Electron Spin Resonance Spectroscopy; Hydrogen-Ion Concentration; Liver; Methods; Microsomes; NADP; Nitric Oxide; Oxidation-Reduction; Oxidoreductases; Phenobarbital; Pigments, Biological; Proteins; Rabbits; Riboflavin; Spectrophotometry | 1968 |
Resolution of the cytochrome P-450-containing omega-hydroxylation system of liver microsomes into three components.
Topics: Animals; Carbon Isotopes; Carbon Monoxide; Cytochromes; Depression, Chemical; Drug Stability; Electron Spin Resonance Spectroscopy; Fatty Acids; Guinea Pigs; Hot Temperature; Hydrogen-Ion Concentration; Kinetics; Lipid Metabolism; Liver; Male; Microsomes; NAD; NADP; Oxidoreductases; Phenobarbital; Rabbits; Rats; Solubility; Spectrophotometry; Stimulation, Chemical | 1969 |
Microsomal hydroxylation of decane.
Topics: Alcohols; Alkanes; Aniline Compounds; Animals; Carbon Isotopes; Carbon Monoxide; Cattle; Chick Embryo; Columbidae; Cyanides; Fatty Acids; Glycols; Hydrogen-Ion Concentration; Kidney; Kinetics; Liver; Lung; Male; Mice; Microsomes; Mixed Function Oxygenases; NADP; Oxygen; Phenobarbital; Proadifen; Rabbits; Rats | 1969 |
Significance of mixed oxygenases and nitroreductase in drug metabolism.
Topics: Animals; Anthelmintics; Carbon Monoxide; Carbon Tetrachloride; Chemical Phenomena; Chemistry; Cytochromes; Haplorhini; Imidazoles; Microsomes, Liver; NADP; Nitrogen; Oxidation-Reduction; Oxidoreductases; Oxygenases; Pharmaceutical Preparations; Phenobarbital | 1969 |
Influence of phenobarbital pretreatment on the in vitro ring A reduction of delta4-3-oxo-steroids in rat liver microsomes.
Topics: 17-Ketosteroids; Androstanes; Animals; Carbon Isotopes; Carbon Monoxide; Chloromercuribenzoates; Chromatography, Thin Layer; Cyanides; Cytochromes; In Vitro Techniques; Male; Microsomes, Liver; Mixed Function Oxygenases; NADP; Phenobarbital; Rats; Stimulation, Chemical | 1969 |
Oxidative demethylation of N-methylhydrazines by rat liver microsomes.
Topics: Animals; Azo Compounds; Bile Acids and Salts; Carbon Monoxide; Cytochromes; Formaldehyde; Hot Temperature; Hydrazines; In Vitro Techniques; Lipase; Methylcholanthrene; Microsomes, Liver; NADP; Oxygen Consumption; Pancreatic Juice; Phenobarbital; Proadifen; Rats | 1969 |
Oxidation of 5 beta-cholestane-3alpha, 7alpha, 12alpha-triol by rat liver microsomes.
Topics: Alcohols; Animals; Bile; Biliary Fistula; Carbon Isotopes; Carbon Monoxide; Cholestanes; Chromatography, Gas; Chromatography, Thin Layer; Male; Microsomes, Liver; NADP; Oxidation-Reduction; Phenobarbital; Rats; Spectrophotometry; Tritium | 1970 |
[Hydroxylation of progesterone by rabbit liver microsomes. Changes in metabolite pattern after phenobarbital treatment of the animals].
Topics: Animals; Biotransformation; Carbon Monoxide; Chromatography, Gel; Chromatography, Paper; Cytochromes; Enzyme Induction; Female; Freezing; Hydrogen-Ion Concentration; Hydroxyprogesterones; Male; Microsomes, Liver; Mixed Function Oxygenases; NADP; Phenobarbital; Progesterone; Rabbits | 1970 |
Omega- and (omega - 1)-oxidation of fatty acids by rat liver microsomes.
Topics: Animals; Carbon Isotopes; Carbon Monoxide; Chromatography, Gas; Depression, Chemical; Dicarboxylic Acids; Fatty Acids; Male; Microsomes, Liver; NAD; NADP; Oxidoreductases; Palmitic Acids; Phenobarbital; Rats; Spectrum Analysis; Stearic Acids; Stimulation, Chemical; Tritium | 1970 |
On the inhibitory action of mersalyl on microsomal drug oxidation: a rigid organization of the electron transport chain.
Topics: Animals; Carbon Monoxide; Chlorides; Cytochromes; Dealkylation; Electron Transport; Fasting; Formaldehyde; Hydrogen-Ion Concentration; Kinetics; Macromolecular Substances; Magnesium; Male; Mercury; Microsomes, Liver; Morphinans; NAD; NADP; Organomercury Compounds; Osmolar Concentration; Oxidation-Reduction; Oxidoreductases; Oxygen Consumption; Phenobarbital; Phosphates; Polarography; Potassium Chloride; Rats; Spectrophotometry; Time Factors; Tromethamine; Ultracentrifugation | 1971 |
Fatty acid inducible cy tochrome P-454 of rat kidney cortex microsomes.
Topics: Aminopyrine; Animals; Carbon Monoxide; Cytochromes; Dietary Fats; Electron Transport; Fatty Acids, Nonesterified; Kidney; Male; Microsomes; Microsomes, Liver; NADP; Oxidation-Reduction; Oxidoreductases; Phenobarbital; Rats; Spectrophotometry; Sulfites; Testosterone | 1970 |
Oxidation of cholesterol, 3 -hydroxy-5-pregnen-20-one and 3 -hydroxy-5-androsten-17-one by rat liver microsomes.
Topics: Animals; Biliary Fistula; Carbon Monoxide; Cholesterol; Chromatography, Gas; Dehydroepiandrosterone; In Vitro Techniques; Linoleic Acids; Lipid Metabolism; Male; Mass Spectrometry; Microsomes, Liver; NADP; Oxidation-Reduction; Phenobarbital; Pregnanes; Rats | 1971 |
The role of microsomes in the hepatic metabolism of ethanol.
Topics: Acetates; Adenine Nucleotides; Aerobiosis; Amino Alcohols; Anaerobiosis; Animals; Azides; Bile Acids and Salts; Carbon Monoxide; Catalase; Cell Fractionation; Chlorides; Chloromercuribenzoates; Copper; Cyanides; Diet; Dimethyl Sulfoxide; Edetic Acid; Ethanol; Female; Hot Temperature; Hydrogen Peroxide; Iron; Liver; Mercury; Microsomes, Liver; NAD; NADP; Oxidoreductases; Phenobarbital; Pyrazoles; Rats; Sulfides; Triazoles | 1971 |
Enzymatic reduction of niridazole by rat liver microsomes.
Topics: Aerobiosis; Animals; Anthelmintics; Carbon Monoxide; Chemical Precipitation; Chromatography, Gas; Cytochromes; Guinea Pigs; Hydroxylamines; Imidazoles; Ketones; Lipase; Liver; Male; Mass Spectrometry; Methylcholanthrene; Mice; Microsomes, Liver; NAD; NADP; Nitro Compounds; Nitrogen; Oxidation-Reduction; Oxidoreductases; Oxygen; Pancreatic Juice; Phenobarbital; Quaternary Ammonium Compounds; Rabbits; Rats; Species Specificity; Spectrophotometry; Sulfates; Tetrazolium Salts; Thiazoles | 1971 |
Preparation and properties of a solubilized form of cytochrome P-450 from chick embryo liver microsomes.
Topics: Acetamides; Allyl Compounds; Animals; Bacillus subtilis; Carbon Monoxide; Cell Fractionation; Chick Embryo; Cytochromes; Depression, Chemical; Detergents; Etiocholanolone; Female; Flavins; Heme; Ketosteroids; Liver; Methods; Methylcholanthrene; Microsomes, Liver; NAD; NADP; Nitrogen; Oxidoreductases; Peptide Hydrolases; Phenobarbital; Pregnanes; Rats; Solubility; Spectrophotometry; Stimulation, Chemical | 1971 |
Formation of a factor lethal for S. typhimurium TA1530 and TA1531 on incubation of aflatoxin B 1 with rat liver microsomes.
Topics: Aflatoxins; Aniline Compounds; Animals; Carbon Monoxide; Caseins; Chromatography, Thin Layer; Depression, Chemical; Diet; Male; Microsomes, Liver; NADP; Nitrogen; Oxygen Consumption; Phenobarbital; Proadifen; Rats; Rats, Inbred Strains; Salmonella typhimurium | 1971 |
The conversion of pyrrolizidine alkaloids to N-oxides and to dihydropyrrolizine derivatives by rat-liver microsomes in vitro.
Topics: Alkaloids; Animals; Calcium; Carbon Monoxide; DDT; Diet; Kinetics; Lung; Magnesium; Manganese; Microsomes; Microsomes, Liver; Models, Biological; NADP; Niacinamide; Oxides; Oxygen; Phenobarbital; Proadifen; Proteins; Pyrroles; Pyrrolizidine Alkaloids; Rats; Rats, Inbred Strains | 1971 |
Influence of 2,4-dichloro-6-phenoxyethyl-amine (DPEA) and -diethylaminoethyl diphenylpropylacetate (SKF-525A) on hepatic microsomal azoreductase activity from phenobarbital or 3-methylcholanthrene induced rats.
Topics: Animals; Azo Compounds; Carbon Monoxide; Chlorine; Cytochromes; Enzyme Activation; Enzyme Induction; Ethylamines; Flavin Mononucleotide; Male; Methylcholanthrene; Microsomes, Liver; NADP; Naphthalenes; Nitrogen; Oxidoreductases; Phenobarbital; Phenols; Proadifen; Rats; Rats, Inbred Strains; Sulfonamides; Sulfonic Acids | 1972 |
A comparative study on the effects of phenobarbital and 3,4-benzpyrene on the hydroxylating enzyme system of rat-liver microsomes.
Topics: Aminopyrine; Animals; Benzopyrenes; Carbon Monoxide; Cytochromes; Enzyme Activation; Male; Microsomes, Liver; Mixed Function Oxygenases; NADP; Oxidoreductases; Phenobarbital; Rats; Rats, Inbred Strains; Spectrophotometry | 1969 |
Enzymatic dechlorination. Dechlorination of chloroethanes and propanes in vitro.
Topics: Animals; Benzopyrenes; Carbon Monoxide; Chlorine; Enzyme Induction; Hydrocarbons, Halogenated; Hydrogen-Ion Concentration; In Vitro Techniques; Kinetics; Male; Methylcholanthrene; Microsomes, Liver; NADP; Oxygen; Phenobarbital; Radioisotopes; Rats; Ultracentrifugation | 1971 |
[Enzymatic luminescence of the microsomes of hepatocytes].
Topics: Animals; Carbon Monoxide; Cytochromes; Electron Transport; Flavoproteins; Heterocyclic Compounds; Luminescent Measurements; Microsomes, Liver; NAD; NADP; Phenobarbital; Rats; Time Factors | 1972 |
Monooxygenase drug metabolizing activity in CaCl 2 -aggregated hepatic microsomes from rat liver.
Topics: Aminopyrine; Aniline Compounds; Animals; Calcium Chloride; Carbon Monoxide; Chlorine; Dronabinol; Enzyme Induction; Male; Microsomes, Liver; Mixed Function Oxygenases; NADP; Oxidoreductases; Phenobarbital; Proadifen; Rats | 1972 |
Cytochrome P-450 in 7 -hydroxylation of taurodeoxycholic acid.
Topics: Animals; Bile Acids and Salts; Carbon Monoxide; Chromatography, Gas; Cytochrome P-450 Enzyme System; Deoxycholic Acid; Hydroxylation; Kinetics; Light; Male; Mathematics; Microsomes, Liver; Mixed Function Oxygenases; NADP; Phenobarbital; Rats; Taurocholic Acid | 1973 |
The monooxygenation of N-heptane by rat liver microsomes.
Topics: Aerobiosis; Alcohols; Alkanes; Animals; Carbon Monoxide; Chromatography, Gas; Cytochrome P-450 Enzyme System; Hydroxylation; In Vitro Techniques; Isomerism; Kinetics; Mass Spectrometry; Metyrapone; Microsomes, Liver; Myocardium; NADP; Oxidation-Reduction; Oxygenases; Phenobarbital; Rats; Rats, Inbred Strains; Swine; Vibration | 1972 |
Spectral analysis of a solubilized hepatic cytochrome P-450 preparation for determination of contamination by cytochrome b5 and unreactive cytochrome P-450.
Topics: Animals; Binding Sites; Carbon Monoxide; Cytochrome P-450 Enzyme System; Cytochrome Reductases; Cytochromes; Dithionite; Male; Microsomes, Liver; Oxidation-Reduction; Phenobarbital; Protein Binding; Rabbits; Solubility; Spectrophotometry; Spectrophotometry, Ultraviolet | 1974 |
Drugs and the liver. I. Effects of glutethimide and phenobarbital on hepatic bilirubin clearance, plasma bilirubin turnover and carbon monoxide production in man.
Topics: Bilirubin; Carbon Monoxide; Carbon Radioisotopes; Chromium Radioisotopes; Female; Gilbert Disease; Glutethimide; Half-Life; Heme; Humans; Liver; Male; Phenobarbital; Time Factors; Tritium | 1974 |
Alteration of carbon monoxide and hypoxic hypoxia-induced lethality following phenobarbital, chlorpromazine, or alcohol pretreatment.
Topics: Animals; Body Temperature; Carbon Monoxide; Carbon Monoxide Poisoning; Carboxyhemoglobin; Chlorpromazine; Diphosphoglyceric Acids; Erythrocytes; Ethanol; Hemoglobins; Hypoxia; Kinetics; Male; Mice; Oxygen Consumption; Phenobarbital | 1974 |
Phenobarbital-mediated increase in ring- and N-hydroxylation of the carcinogen N-2-fluorenylacetamide, and decrease in amounts bound to liver deoxyribonucleic acid.
Topics: Acetamides; Animals; Body Weight; Carbon Isotopes; Carbon Monoxide; Carcinogens; Chromatography, Paper; Cytochrome P-450 Enzyme System; DNA; Fluorenes; Hydroxylation; In Vitro Techniques; Liver; Microsomes, Liver; Organ Size; Phenobarbital; Proteins; Rats | 1972 |
Effect of phenobarbital and naphthalene on some of the components of the electron transport system and the hydroxylating activity of house fly microsomes.
Topics: Aminopyrine; Animals; Binding Sites; Binding, Competitive; Carbon Monoxide; Cytochrome P-450 Enzyme System; Cytochrome Reductases; Cytochromes; Electron Transport; Enzyme Induction; Female; Houseflies; Hydroxylation; Male; Microsomes; Naphthalenes; Phenobarbital; Propoxur; Species Specificity; Spectrophotometry | 1973 |
Existence and separation of three forms of cytochrome P-450 from rat liver microsomes.
Topics: Amines; Animals; Carbon Isotopes; Carbon Monoxide; Chromatography, DEAE-Cellulose; Cyanides; Cytochrome P-450 Enzyme System; Cytochromes; Deoxycholic Acid; Enzyme Induction; Ethanol; Male; Methylcholanthrene; Microsomes, Liver; Phenobarbital; Protein Binding; Rats; Solubility; Spectrophotometry; Subtilisins | 1973 |
Microsomal drug oxidation. Function, induction, and inhibition of the cytochrome P450-system.
Topics: Animals; Benzopyrenes; Binding Sites; Carbon Monoxide; Cytochrome P-450 Enzyme System; Depression, Chemical; Enzyme Induction; Humans; Microsomes, Liver; Oxidation-Reduction; Phenobarbital; Proadifen; Rabbits; Rats; Spectrophotometry | 1973 |
Regulation of hydroxylation of 5 alpha-androstane-3 beta, 17 beta-diol in liver microsomes from male and female rats.
Topics: Androstanes; Animals; Carbon Isotopes; Carbon Monoxide; Castration; Chromatography, Gas; Chromatography, Gel; Chromatography, Thin Layer; Dihydrotestosterone; Estradiol; Female; Hydroxylation; Hydroxysteroids; Male; Mass Spectrometry; Methylcholanthrene; Microsomes, Liver; Mixed Function Oxygenases; Phenobarbital; Pregnenolone; Rats; Sex Factors; Testis; Testosterone; Time Factors | 1973 |
Some spectral properties of cytochrome P-450 from microsomes isolated from control, phenobarbital- and naphthalene-treated houseflies.
Topics: Aniline Compounds; Animals; Carbon Monoxide; Cyanides; Cytochrome P-450 Enzyme System; Houseflies; Ligands; Microsomes; Naphthalenes; Nucleic Acid Conformation; Phenobarbital; Proadifen; Protein Conformation; Spectrophotometry; Spectrophotometry, Ultraviolet | 1973 |
Omega- and (omega-1)-hydroxylation of 4-chloropropionanilide in liver microsomes of rabbits treated with phenobarbital or 3-methylcholanthrene.
Topics: Acetophenones; Anilides; Animals; Carbon Monoxide; Chlorine; Drug Storage; Female; Hydroxylation; Hypoxia; In Vitro Techniques; Male; Methylcholanthrene; Microsomes, Liver; Phenobarbital; Pressure; Propionates; Rabbits; Time Factors | 1973 |
Omega- and (omega-1)-hydroxylation of 4-chloropropionanilide in liver microsomes of rabbits treated weith phenobarbital or 3-methylcholanthrene.
Topics: Acetanilides; Acetophenones; Anilides; Animals; Carbon Monoxide; Hydroxylation; In Vitro Techniques; Methylcholanthrene; Microsomes, Liver; Oxygen; Phenobarbital; Pressure; Propionates; Rabbits; Time Factors; Tissue Preservation | 1973 |
Regulation and properties of a sex-specific hydroxylase system in female rat liver microsomes active on steroid sulfates. I. General characteristics.
Topics: Age Factors; Androstanes; Animals; Carbon Monoxide; Carbon Radioisotopes; Castration; Estradiol; Female; Hydroxysteroids; Male; Methylcholanthrene; Microsomes, Liver; Phenobarbital; Pregnenolone Carbonitrile; Proadifen; Rats; Sex Factors; Steroid Hydroxylases; Sulfuric Acids; Testosterone | 1974 |
The use of new methods to measure: the effect of diet and inducers of microsomal enzyme synthesis on cytochrome P-450 in liver homogenates, and on metabolism of dimethyl nitrosamine.
Topics: Animals; Benzopyrenes; Carbon Monoxide; Cytochrome P-450 Enzyme System; Dealkylation; Diet; Dietary Fats; Dietary Proteins; Dimethylamines; Enzyme Induction; Formaldehyde; In Vitro Techniques; Kinetics; Liver; Methods; Microsomes, Liver; Nitrosamines; Oxidation-Reduction; Phenobarbital; Rats; Stimulation, Chemical | 1974 |
Influence of pyridine and some pyridine derivatives on spectral properties of reduced microsomes and on microsomal drug metabolizing activity.
Topics: Aminopyrine N-Demethylase; Aniline Compounds; Animals; Anisoles; Carbon Monoxide; Chemical Phenomena; Chemistry; Coenzymes; Cytochrome P-450 Enzyme System; Hydrogen-Ion Concentration; In Vitro Techniques; Ligands; Male; Methylcholanthrene; Metyrapone; Microsomes, Liver; Mixed Function Oxygenases; Pharmaceutical Preparations; Phenobarbital; Pyridines; Rats; Spectrophotometry, Ultraviolet | 1974 |
Crigler-Najjar syndrome: an unusual course with development of neurologic damage at age eighteen.
Topics: Adolescent; Alkaline Phosphatase; Bilirubin; Brain Damage, Chronic; Brain Diseases; Carbon Monoxide; Erythrocyte Aging; Female; Glucuronates; Glutethimide; Humans; Hyperbilirubinemia, Hereditary; Indocyanine Green; Kanamycin; Liver Function Tests; Phenobarbital; Phenytoin; Phototherapy; Plasmapheresis; Protein Binding; Radioisotopes; Renal Dialysis; Salicylamides; Sulfobromophthalein; Syndrome; Transaminases | 1974 |
Photodissociation of Fe2+-CO by continuous irradiation.
Topics: Animals; Binding Sites; Carbon Monoxide; Cattle; Cytochrome P-450 Enzyme System; Iron; Kinetics; Light; Lighting; Microsomes, Liver; Pancreas; Peptide Hydrolases; Phenobarbital; Photochemistry; Protein Binding; Rats; Spectrometry, Fluorescence; Spectrophotometry; Spectrophotometry, Ultraviolet; Temperature; Trypsin | 1974 |
Propylene glycol as a drug solvent in the study of hepatic microsomal enzyme metabolism in the rat.
Topics: Aminopyrine; Aniline Compounds; Animals; Anisoles; Benzoates; Carbon Monoxide; Cytochrome P-450 Enzyme System; Dealkylation; Dose-Response Relationship, Drug; Hexobarbital; Hydroxylation; In Vitro Techniques; Kinetics; Male; Microsomes, Liver; Nitro Compounds; Pharmaceutical Preparations; Phenobarbital; Propylene Glycols; Rats; Sleep; Solvents; Time Factors | 1974 |
Studies on heme transfer from microsomal hemoproteins to heme-binding plasma proteins.
Topics: Animals; Apoproteins; Biological Transport; Blood Proteins; Carbon Monoxide; Chromatography, DEAE-Cellulose; Cytochrome P-450 Enzyme System; Cytochromes; Heme; Hemeproteins; Hemopexin; In Vitro Techniques; Levulinic Acids; Male; Microsomes, Liver; Oxidation-Reduction; Phenobarbital; Protein Binding; Rats; Serum Albumin; Spectrophotometry, Ultraviolet; Tritium | 1974 |
The formation of biliverdin by chicken macrophages in tissue culture. Observations on the effect of inhibitors.
Topics: Acetanilides; Animals; Ascorbic Acid; Azides; Bile Pigments; Carbon Monoxide; Chickens; Chloramphenicol; Culture Techniques; Cyanides; Cycloheximide; Dactinomycin; Erythrocytes; Ethylmaleimide; Female; Heme; Hydrogen Peroxide; Macrophages; Metabolism; Microscopy, Phase-Contrast; Mitomycins; Phagocytosis; Phenobarbital; Proadifen; Quinacrine; Spectrophotometry; Spectrum Analysis; Stimulation, Chemical; Triazoles | 1970 |
Partial purification of cytochromes P-450 and P-448 from rat liver microsomes.
Topics: Ammonium Sulfate; Animals; Benzopyrenes; Benzphetamine; Calcium Phosphates; Carbon Monoxide; Chemical Precipitation; Cytochromes; Gels; Male; Methylcholanthrene; Microsomes, Liver; Phenobarbital; Rats; Spectrophotometry | 1972 |
Effect of enzyme induction on the metabolism of benzo(a)pyrene and 3'-methyl-4-monomethylaminoazobenzene in the pregnant and fetal rat.
Topics: Animals; Azo Compounds; Benzopyrenes; Carbon Monoxide; Carcinogens; Cyanides; Cytochromes; Dealkylation; Enzyme Induction; Female; Fetus; Liver; Methylcholanthrene; Microsomes, Liver; Mixed Function Oxygenases; Oxidoreductases; Phenobarbital; Pregnancy; Rats; Spectrophotometry; Tritium | 1972 |
Mixed function oxidase and ethanol metabolism in perfused rat liver.
Topics: Aminopyrine; Animals; Carbon Monoxide; Cytochromes; Ethanol; In Vitro Techniques; Male; Microsomes, Liver; Oxidation-Reduction; Oxygen Consumption; Perfusion; Phenobarbital; Pigments, Biological; Rats | 1972 |
Studies on drug metabolism. 13. Possible role of liver microsomal cytochrome P-450 in the oxidative N-demethylation of p-substituted dimethylaniline, N-methyl-N-alkylaniline and N-methyl-N-acylaniline derivatives.
Topics: Aniline Compounds; Animals; Carbon Monoxide; Cytochromes; Male; Methylation; Microsomes, Liver; Phenobarbital; Proadifen; Rats; Rats, Inbred Strains | 1972 |
Chromatography of radioactive microsomal hemoproteins on diethylaminoethyl cellulose.
Topics: Animals; Carbon Isotopes; Carbon Monoxide; Chromatography, DEAE-Cellulose; Cytochromes; Heme; Kinetics; Levulinic Acids; Male; Methylcholanthrene; Microsomes, Liver; Phenobarbital; Protein Binding; Proteins; Rats; Rats, Inbred Strains; Solubility; Time Factors; Tritium | 1971 |
Effects of inducers of liver microsomal enzymes on the composition of microsomal hemoprotein.
Topics: Animals; Benzopyrenes; Carbon Monoxide; Chlordan; Cytochromes; Enzyme Induction; Heme; Hemeproteins; Hydroxylation; In Vitro Techniques; Levulinic Acids; Male; Methylcholanthrene; Microsomes, Liver; Mixed Function Oxygenases; Phenobarbital; Rats; Time Factors; Tritium | 1971 |
Carbon monoxide production and heme catabolism.
Topics: Acetamides; Allyl Compounds; Anemia, Sideroblastic; Animals; Bile Pigments; Bone Marrow; Carbon Isotopes; Carbon Monoxide; Dogs; Erythrocytes; Erythropoiesis; Glycine; Heme; Hemoglobins; Humans; Levulinic Acids; Liver; Mononuclear Phagocyte System; Phenobarbital; Porphyrias; Reticulocytes; Time Factors | 1970 |
Kinetic aspects of endogenous carbon monoxide production in experimental animals.
Topics: Acetamides; Allyl Compounds; Anemia, Hypochromic; Animals; Birds; Blood Transfusion; Carbon Isotopes; Carbon Monoxide; Cell Survival; Erythrocyte Aging; Erythropoiesis; Female; Glycine; Hematocrit; Heme; Hemoglobins; Hemolysis; Iron Isotopes; Kinetics; Male; Methods; Mice; Phenobarbital; Phenylhydrazines; Rats; Reticulocytes; Time Factors; Veins | 1970 |
Metyrapone interaction with hepatic microsomal cytochrome P-450 from rats treated with phenobarbital.
Topics: Animals; Carbon Monoxide; Cytochromes; Depression, Chemical; Kinetics; Liver; Male; Metyrapone; Microsomes, Liver; Models, Biological; Oxidation-Reduction; Phenobarbital; Rats; Spectrophotometry; Stimulation, Chemical | 1969 |
Participation of the microsomal electron transport system involving cytochrome P-450 in 7alpha-hydroxylation of cholesterol.
Topics: Animals; Antibodies; Biliary Fistula; Carbon Isotopes; Carbon Monoxide; Cholesterol; Cytochromes; Electron Transport; Fasting; Hydrocortisone; Male; Methylcholanthrene; Microsomes, Liver; Mixed Function Oxygenases; Oxidoreductases; Phenobarbital; Proteins; Rabbits; Rats; Thyroxine | 1969 |
Enhancement by phenobarbital and diphenylhydantoin of carbon monoxide production in normal man.
Topics: Adult; Bilirubin; Carbon Monoxide; Heme; Humans; Liver; Male; Phenobarbital; Phenytoin | 1970 |
A simple radiometric assay for microsomal aryl hydroxylase activity.
Topics: Acetanilides; Administration, Oral; Animals; Carbon Isotopes; Carbon Monoxide; Enzyme Induction; Injections; Liver; Male; Methods; Methylcholanthrene; Microsomes, Liver; Mixed Function Oxygenases; Phenobarbital; Radiochemistry; Rats; Stimulation, Chemical; Sulfonamides; Time Factors; Tritium | 1970 |
Catabolism of heme in vivo: comparison of the simultaneous production of bilirubin and carbon monoxide.
Topics: Animals; Bile; Bilirubin; Carbon Isotopes; Carbon Monoxide; Feces; Glycine; Heme; Injections, Intravenous; Liver; Phenobarbital; Rats; Respiration; Urea | 1970 |
Redox-dependent conformational changes of rabbit liver cytochrome P-450.
Topics: Animals; Carbon Monoxide; Chemical Phenomena; Chemistry; Cytochromes; Endoplasmic Reticulum; Heme; Liver; Microsomes, Liver; Optical Rotatory Dispersion; Oxidation-Reduction; Phenobarbital; Pigments, Biological; Rabbits; Spectrophotometry; Ultraviolet Rays | 1970 |
Nickel carbonyl inhibition of induction of aminopyrine demethylase activity in liver and lung.
Topics: Aminopyrine; Animals; Carbon Monoxide; Cell Membrane; Cell Nucleus; Endoplasmic Reticulum; Enzyme Induction; Liver; Lung; Male; Microsomes, Liver; Nickel; Oxidoreductases; Phenobarbital; Phenothiazines; Rats; RNA Nucleotidyltransferases; RNA, Messenger; Time Factors; Tryptophan Oxygenase | 1970 |
Species differences in the induction of microsomal hemoproteins and 3,4-benzpyrene hydroxylase by phenobarbital and 3-methylcholanthrene.
Topics: Animals; Benzopyrenes; Blood Proteins; Carbon Monoxide; Cytochromes; Enzyme Induction; Guinea Pigs; Kinetics; Male; Methylcholanthrene; Mice; Microsomes, Liver; Mixed Function Oxygenases; Phenobarbital; Rabbits; Rats; Species Specificity; Spectrum Analysis | 1970 |
Further evidene on the nature of microsomal metabolism of procarbazine and related alkyhydrazines.
Topics: Animals; Benzoates; Carbon Monoxide; Cytochromes; Enzyme Induction; Hydrazines; Male; Methylcholanthrene; Microsomes, Liver; Nitrogen; Oxidoreductases; Oxygen; Phenobarbital; Proadifen; Rats; Sheep; Swine; Trypsin | 1970 |
Cytochrome b5 and CO-binding cytochromes in the Golgi membranes of mammalian livers.
Topics: Animals; Carbon Monoxide; Chemical Phenomena; Chemistry; Copper; Cytochromes; Golgi Apparatus; Liver; Manganese; Membranes; Metabolism; Methylcholanthrene; Microscopy, Electron; Microsomes; Phenobarbital; Proteins; Rabbits; RNA; Sodium; Spectrophotometry | 1970 |
Aminopyrine demethylase. Kinetic evidence for multiple microsomal activities.
Topics: Aminopyrine; Animals; Carbon Monoxide; Chromatography, Thin Layer; Cytochromes; Dealkylation; Enzyme Induction; Ethionine; Goats; Isoenzymes; Kinetics; Male; Methylcholanthrene; Microsomes, Liver; Oxidoreductases; Phenobarbital; Proadifen; Rats; Spectrophotometry; Stimulation, Chemical; Sulfites | 1970 |
Enzymic 6-hydroxylation of indolealkylamines and related compounds.
Topics: Aging; Amines; Animals; Buffers; Carbon Monoxide; Chemical Phenomena; Chemistry, Physical; Depression, Chemical; Female; Humans; Hydrogen-Ion Concentration; Indoles; Liver; Male; Microsomes; Mixed Function Oxygenases; Oxidation-Reduction; Phenobarbital; Rabbits; Rats; Sex Factors; Spectrophotometry; Stimulation, Chemical; Temperature | 1968 |
Alteration of the microsomal hemoprotein by 3-methylcholanthrene: effects of ethionine and actinomycin D.
Topics: Animals; Benzopyrenes; Carbon Monoxide; Cytochromes; Dactinomycin; Enzyme Induction; Ethionine; Liver; Male; Methionine; Methylcholanthrene; Microsomes; Mixed Function Oxygenases; Phenobarbital; Rats; Solubility; Spectrophotometry | 1968 |
Studies on hepatic microsomal N- and O-dealkylation of morphine analogues.
Topics: Animals; Carbon Monoxide; Cytochromes; Fasting; Hexobarbital; Hot Temperature; Kinetics; Light; Liver; Male; Microsomes; Morphine; Phenobarbital; Rats | 1968 |
Participation of P-450 in 7 alpha-hydroxylation of cholesterol.
Topics: Animals; Carbon Isotopes; Carbon Monoxide; Chemical Precipitation; Cholesterol; Chromatography, Thin Layer; Liver; Male; Microsomes; Phenobarbital; Pigments, Biological; Rats | 1968 |
Substrate-inducible microsomal aryl hydroxylase in mammalian cell culture. II. Cellular responses during enzyme induction.
Topics: Aging; Animals; Benz(a)Anthracenes; Brain; Carbon Monoxide; Chick Embryo; Cricetinae; Culture Techniques; Cycloheximide; Cytochromes; Dactinomycin; Enzyme Induction; Fetus; Guinea Pigs; Intestine, Small; Kinetics; Liver; Lung; Mice; Microsomes; Mixed Function Oxygenases; Phenobarbital; Puromycin; Rats; RNA, Messenger; Spectrum Analysis; Time Factors | 1968 |
Studies on microsomal hydroxylation and the demonstration of a new carbon monoxide binding pigment in liver microsomes.
Topics: Age Factors; Animals; Carbon Monoxide; Chemical Phenomena; Chemistry; Cytochromes; Enzyme Induction; Freezing; In Vitro Techniques; Male; Methylcholanthrene; Microsomes, Liver; Phenobarbital; Pigments, Biological; Rats; Spectrophotometry; Testosterone | 1968 |
Induction of drug metabolism. II. Qualitative differences in the microsomal N-demethylating systems stimulated by polycyclic hydrocarbons and by phenobarbital.
Topics: Animals; Benzene Derivatives; Benzopyrenes; Carbon Monoxide; Cyanides; Cytochromes; Depression, Chemical; Female; Formaldehyde; Kinetics; Liver; Male; Methylcholanthrene; Mice; Microsomes; Morphinans; Morphine; Phenobarbital; Proadifen; Rats; Sex Factors; Species Specificity; Stimulation, Chemical; Valerates | 1969 |
N-oxygenation of N-alkyl- and N,N-dialkylanilines by rabbit liver microsomes.
Topics: Aniline Compounds; Animals; Carbon Monoxide; Chloromercuribenzoates; Ethylmaleimide; Female; Liver; Microsomes; Oxygen; Phenanthrolines; Phenobarbital; Phenols; Quinolines; Rabbits; Semicarbazides; Spectrophotometry; Swine | 1969 |
Biphasic decrease of radioactive hemoprotein from liver microsomal carbon monoxide-binding particles. Effect of phenobarbital and chlordane.
Topics: Age Factors; Animals; Carbon Monoxide; Chlordan; Cytochromes; Levulinic Acids; Male; Methylcholanthrene; Microsomes, Liver; Phenobarbital; Protein Binding; Rats; Tritium | 1969 |
Studies on the enzymic hydroxylation of 3,4-benzpyrene.
Topics: Aging; Animals; Benzopyrenes; Carbon Monoxide; Enzyme Induction; Ethanol; Glycerol; Hydrogen-Ion Concentration; Kinetics; Liver; Male; Microsomes; Mixed Function Oxygenases; Phenobarbital; Pigments, Biological; Rats; Spectrophotometry; Surface-Active Agents; Tritium; Venoms | 1967 |
[Method of quantitative determination of cytochrome P-450 in mouse liver homogenate].
Topics: Animals; Carbon Monoxide; Cytochrome P-450 Enzyme System; Liver; Male; Mice; Phenobarbital; Spectrophotometry | 1984 |
Developmental changes in bilirubin production in the rat.
Topics: Age Factors; Aminolevulinic Acid; Animals; Bilirubin; Carbon Dioxide; Carbon Monoxide; Glycine; Heme Oxygenase (Decyclizing); Intestinal Mucosa; Liver; Phenobarbital; Rats; Rats, Inbred Strains; Respiration | 1983 |
The metabolism of 4-substituted N-ethyl-N-methylanilines. III. Effect of various potential inhibitors, activators and inducers on alpha-C- and N-oxidation.
Topics: Aniline Compounds; Animals; Carbon Monoxide; Cricetinae; Cytochrome P-450 Enzyme System; Enzyme Activation; Enzyme Induction; Guinea Pigs; In Vitro Techniques; Male; Methylcholanthrene; Microsomes, Liver; Oxidoreductases; Phenobarbital | 1983 |
High pressure liquid chromatographic separation of multiple forms of cytochrome P-450.
Topics: Animals; Carbon Monoxide; Chromatography, High Pressure Liquid; Cytochrome P-450 Enzyme System; Enzyme Induction; Isoenzymes; Kinetics; Male; Microsomes, Liver; Molecular Weight; Phenobarbital; Rats; Rats, Inbred Strains | 1983 |
Detection of phenobarbital-induced cytochrome P-450 in rat hepatic microsomes using an enzyme-linked immunosorbent assay.
Topics: Animals; Carbon Monoxide; Cytochrome P-450 Enzyme System; Enzyme Induction; Enzyme-Linked Immunosorbent Assay; Kinetics; Microsomes, Liver; Molecular Weight; Oxidation-Reduction; Phenobarbital; Rats; Rats, Inbred Strains; Substrate Specificity | 1984 |
Phenobarbital-induced rat liver cytochrome P-450. Purification and characterization of two closely related isozymic forms.
Topics: Animals; Carbon Monoxide; Cytochrome P-450 Enzyme System; Isoenzymes; Male; Metyrapone; Microsomes, Liver; Molecular Weight; NADPH-Ferrihemoprotein Reductase; Phenobarbital; Rats; Rats, Inbred Strains; Spectrophotometry; Substrate Specificity | 1982 |
Kinetics and mechanism of CO binding to cytochromes P-450LM2 and P-450LM4. Effect of phospholipid, nonionic detergent, and substrate binding.
Topics: Animals; Carbon Monoxide; Cytochrome P-450 Enzyme System; Dithionite; Kinetics; Microsomes, Liver; Phenobarbital; Phospholipids; Protein Binding; Rabbits | 1983 |
Formation of (4R)- and (4S)-4-hydroxyochratoxin A and 10-hydroxyochratoxin A from Ochratoxin A by rabbit liver microsomes.
Topics: Animals; Carbon Monoxide; Chemical Phenomena; Chemistry; Hydroxylation; Magnetic Resonance Spectroscopy; Male; Metyrapone; Microsomes, Liver; NADP; Ochratoxins; Phenobarbital; Rabbits | 1983 |
Kinetics and mechanism of carbon monoxide binding to purified liver microsomal cytochrome P-450 isozymes.
Topics: Animals; Benzoflavones; beta-Naphthoflavone; Carbon Monoxide; Cytochrome P-450 Enzyme System; Isoenzymes; Kinetics; Male; Microsomes, Liver; Phenobarbital; Protein Binding; Rabbits; Rats; Rats, Inbred Strains; Spectrophotometry | 1982 |
Rotation of cytochrome P-450. I. Investigations of protein-protein interactions of cytochrome P-450 in phospholipid vesicles and liver microsomes.
Topics: Animals; Carbon Monoxide; Cytochrome P-450 Enzyme System; Kinetics; Liposomes; Male; Mathematics; Microsomes, Liver; Phenobarbital; Phosphatidylcholines; Phosphatidylethanolamines; Phosphatidylserines; Protein Binding; Protein Conformation; Rats; Rats, Inbred Strains | 1982 |
Limitations on the metyrapone assay for the major phenobarbital inducible form of cytochrome P-450.
Topics: Animals; Carbon Monoxide; Cytochrome P-450 Enzyme System; Kinetics; Male; Metyrapone; Microsomes, Liver; Phenobarbital; Rats; Substrate Specificity | 1982 |
Hydrodynamic properties of monomeric cytochromes P-450LM2 and P-450LM4 in n-octylglucoside solution.
Topics: Animals; Carbon Monoxide; Cytochrome P-450 Enzyme System; Glucosides; Glycosides; Kinetics; Macromolecular Substances; Microsomes, Liver; Phenobarbital; Rabbits; Spectrophotometry | 1982 |
Suicidal inactivation of microsomal cytochrome P-450 by halothane under hypoxic conditions.
Topics: Aerobiosis; Anaerobiosis; Animals; Carbon Monoxide; Cytochrome P-450 Enzyme Inhibitors; Halothane; Kinetics; Male; Microsomes, Liver; Oxygen; Partial Pressure; Phenobarbital; Protein Binding; Rats | 1982 |
Use of linoleic acid hydroperoxide in the determination of absolute spectra of membrane-bound cytochrome P-450.
Topics: Animals; Carbon Monoxide; Cytochrome P-450 Enzyme System; In Vitro Techniques; Linoleic Acids; Lipid Peroxides; Liver; Male; Membranes; Methylcholanthrene; Oxidation-Reduction; Phenobarbital; Rats | 1981 |
Effects of inducers and/or inhibitors on metabolism of lysergic acid diethylamide in rat liver microsomes.
Topics: Animals; Biotransformation; Carbon Monoxide; Enzyme Induction; Enzyme Inhibitors; In Vitro Techniques; Lysergic Acid Diethylamide; Methylcholanthrene; Microsomes, Liver; NAD; Oxygen Consumption; Phenobarbital; Proadifen; Rats | 1980 |
Testosterone oxidation by rat liver microsomes: effects of phenobarbital pretreatment and the detection of seven metabolites by HPLC.
Topics: Animals; Carbon Monoxide; Chromatography, High Pressure Liquid; Male; Microsomes, Liver; Oxidation-Reduction; Phenobarbital; Rats; Testosterone | 1981 |
Metabolism of haloforms to carbon monoxide. IV. studies on the reaction mechanism in vivo.
Topics: Animals; Carbon Monoxide; Carcinogens; Chloroform; Cysteine; Deuterium; Hydrocarbons, Brominated; Male; Maleates; Phenobarbital; Pyrrolidonecarboxylic Acid; Rats; Rats, Inbred Strains; Thiazoles; Thiazolidines; Trihalomethanes | 1981 |
The role of cytochrome P-450 in the synthesis of polar metabolites of aldosterone by microsomes of male rat liver.
Topics: Aldosterone; Animals; Carbon Monoxide; Cytochrome P-450 Enzyme System; Hydrogen-Ion Concentration; In Vitro Techniques; Kinetics; Male; Microsomes, Liver; Phenobarbital; Proadifen; Rats; Rats, Inbred Strains | 1981 |
Studies of metabolism of tripamide, a new antihypertensive agent. II. Metabolism by the hepatic microsomal enzymes.
Topics: Aminopeptidases; Animals; Antibodies; Antihypertensive Agents; Carbon Monoxide; Cytochrome P-450 Enzyme System; Hydrolysis; Hydroxylation; In Vitro Techniques; Indoles; Male; Methylcholanthrene; Microsomes, Liver; Phenobarbital; Phenylphosphonothioic Acid, 2-Ethyl 2-(4-Nitrophenyl) Ester; Rats | 1981 |
The heme protein P-450 in oxygen activation: carbon monoxide inhibition and photochemical action spectroscopy as tools to study its catalytic role.
Topics: Animals; Carbon Monoxide; Cytochrome P-450 Enzyme System; Hemeproteins; Kinetics; Light; Male; Microsomes, Liver; Oxidoreductases, N-Demethylating; Oxygen Consumption; Phenobarbital; Photochemistry; Rats; Rats, Inbred Strains | 1981 |
Production of carbon monoxide by sonication of medium containing glycerol. Effect on cytochrome P-450 reconstituted systems.
Topics: Animals; Carbon Monoxide; Cytochrome P-450 Enzyme System; Dithionite; Glycerol; Hemoglobins; Humans; Kinetics; Methylcholanthrene; Microsomes, Liver; Phenobarbital; Rats; Sonication; Spectrophotometry | 1981 |
Liver microsomal metabolism of N-methylcarbazole: a probe for induction, inhibition, and species differences.
Topics: Animals; Benzoflavones; Carbazoles; Carbon Monoxide; Chromatography, High Pressure Liquid; Cytochrome P-450 Enzyme Inhibitors; Methylcholanthrene; Metyrapone; Mice; Microsomes, Liver; NAD; NADP; Phenobarbital; Proadifen; Rabbits; Rats; Species Specificity | 1980 |
Inactivation of purified rat liver cytochrome P-450 by chloramphenicol.
Topics: Amino Acids; Animals; Carbon Monoxide; Chloramphenicol; Cytochrome P-450 Enzyme Inhibitors; In Vitro Techniques; Liver; Male; Mixed Function Oxygenases; NADP; Phenobarbital; Rats | 1980 |
Carbon tetrachloride-altered binding of carbon monoxide to reduced cytochrome P-450 in phenobarbital microsomes.
Topics: Animals; Carbon Monoxide; Carbon Tetrachloride; Cytochrome P-450 Enzyme System; Male; Microsomes, Liver; Oxidation-Reduction; Phenobarbital; Rats | 1980 |
Metabolism of dihalomethanes to carbon monoxide. IV. Studies in isolated rat hepatocytes.
Topics: Animals; Carbon Monoxide; Hydrocarbons, Halogenated; In Vitro Techniques; Kinetics; Liver; Male; Methane; Methylcholanthrene; Phenobarbital; Proadifen; Rats | 1980 |
Purification and characterization of a newly identified isoform of cytochrome P450 responsible for 3-hydroxylation of 2,5,2',5'-tetrachlorobiphenyl in hamster liver.
Topics: Amino Acid Sequence; Animals; Carbon Monoxide; Catalysis; Cricetinae; Cytochrome P-450 Enzyme System; Electrophoresis, Polyacrylamide Gel; Hydroxylation; Immune Sera; Isoenzymes; Male; Mesocricetus; Microsomes, Liver; Molecular Sequence Data; Molecular Weight; Oxidation-Reduction; Phenobarbital; Polychlorinated Biphenyls | 1995 |
Administration of high doses of human recombinant interleukin-2 decreases the expression of several cytochromes P-450 in the rat.
Topics: Animals; Carbon Monoxide; Cytochrome P-450 Enzyme System; Cytochromes b5; Drug Interactions; Humans; Interleukin-2; Isoenzymes; Liver; Male; Methylcholanthrene; Microsomes, Liver; NADPH-Ferrihemoprotein Reductase; Organ Size; Phenobarbital; Rats; Rats, Sprague-Dawley; Recombinant Proteins | 1994 |
Biotransformation of glyceryl trinitrate by rat aortic cytochrome P450.
Topics: Animals; Aorta; Biotransformation; Carbon Monoxide; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Enzyme Induction; Kinetics; Microsomes; Microsomes, Liver; Nitroglycerin; Oxygen; Phenobarbital; Proadifen; Rats | 1993 |
Cytochrome P450 monooxygenase activity in Haemonchus contortus (Nematoda).
Topics: 7-Alkoxycoumarin O-Dealkylase; Animals; Carbon Monoxide; Cytochrome P-450 Enzyme System; Haemonchus; Kinetics; Larva; Microsomes; Mixed Function Oxygenases; NADP; Phenobarbital; Piperonyl Butoxide; Sheep; Substrate Specificity | 1997 |
Covalent binding of a reactive metabolite derived from propranolol and its active metabolite 4-hydroxypropranolol to hepatic microsomal proteins of the rat.
Topics: Adrenergic beta-Antagonists; Animals; Biotransformation; Carbon Monoxide; Cytochrome P-450 Enzyme System; Enzyme Induction; Female; In Vitro Techniques; Male; Microsomes, Liver; Naphthalenes; Phenobarbital; Propranolol; Protein Binding; Rabbits; Rats; Superoxides | 1997 |
Reductive activation of 1,1-dichloro-1-fluoroethane (HCFC-141b) by phenobarbital- and pyridine-induced rat liver microsomal cytochrome P450.
Topics: Alkenes; Anaerobiosis; Animals; Biotransformation; Carbon Monoxide; Chlorofluorocarbons; Chlorofluorocarbons, Ethane; Cyclic N-Oxides; Cytochrome P-450 CYP2B1; Cytochrome P-450 CYP2E1; Cytochrome P-450 Enzyme System; Glutathione; Heme; Male; Microsomes, Liver; NADP; Nitrogen Oxides; Oxidation-Reduction; Phenobarbital; Pyridines; Rats; Rats, Wistar | 1996 |
Production of carbon monoxide by cytochrome P450 during iron-dependent lipid peroxidation.
Topics: alpha-Tocopherol; Animals; Aryl Hydrocarbon Hydroxylases; Carbon Monoxide; Cytochrome P-450 Enzyme System; Deferoxamine; Enzyme Induction; Enzyme Inhibitors; Heme Oxygenase (Decyclizing); In Vitro Techniques; Iron; Lipid Peroxidation; Metyrapone; Microsomes, Liver; Phenobarbital; Proadifen; Protoporphyrins; Rabbits; Steroid Hydroxylases | 2002 |
Studies on the induction of CO-binding pigments in liver microsomes by phenobarbital and 3-methylcholanthrene.
Topics: Animals; Benzopyrene Hydroxylase; Carbon Monoxide; Carcinogens; Carrier Proteins; Ethionine; Hemeproteins; Hypnotics and Sedatives; Injections, Intraperitoneal; Male; Methylcholanthrene; Microsomes, Liver; Nitriles; Phenobarbital; Pigments, Biological; Rats; Rats, Sprague-Dawley; Spectrophotometry | 1967 |