carbogen has been researched along with niacinamide in 115 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 63 (54.78) | 18.2507 |
| 2000's | 35 (30.43) | 29.6817 |
| 2010's | 14 (12.17) | 24.3611 |
| 2020's | 3 (2.61) | 2.80 |
| Authors | Studies |
|---|---|
| Horsman, MR | 2 |
| Denekamp, J; Joiner, MC; Rojas, A | 1 |
| Brown, JM | 1 |
| Dennis, MF; Dische, S; Hall, DW; Hodgkiss, RJ; Joiner, MC; Rojas, A; Stratford, MR | 1 |
| Aoki, DS; Chaplin, DJ; Horsman, MR | 1 |
| Dische, S; Pigott, K; Saunders, MI | 1 |
| de Koster, A; Grotenhuis, JA; Kaanders, JH; Keyser, A; Prick, MJ; Thijssen, HO; van der Kogel, AJ; van der Maazen, RW; Wesseling, P | 1 |
| Chaplin, DJ; Horsman, MR; Khalil, AA; Nordsmark, M; Overgaard, J; Siemann, DW | 1 |
| Bleehen, NM; Dennis, IF; Laurence, VM; Ward, R | 1 |
| Fenton, BM | 1 |
| Guichard, M; Prade, M; Thomas, CD | 1 |
| Fenton, BM; Siemann, DW | 1 |
| Grau, C; Horsman, MR; Overgaard, J | 1 |
| Bleehen, NM; Honess, DJ | 1 |
| Hoskin, PJ; Saunders, MI | 1 |
| Guichard, M; Martin, LM; Thomas, CD | 1 |
| Raabe, A | 1 |
| Chaplin, DJ; Hill, SA; Horsman, MR; Khalil, AA; Nordsmark, M; Overgaard, J; Siemann, DW | 1 |
| Denekamp, J; Dennis, M; Franzén, L; Henriksson, R; Littbrand, B; Rojas, AM; Stratford, M; Zackrisson, B | 1 |
| Chaplin, DJ; Horsman, MR; Siemann, DW | 2 |
| Haustermans, K; van der Kogel, AJ; van der Schueren, E; Vanacker, B | 1 |
| Akaboshi, M; Akuta, K; Masunaga, S; Ono, K | 1 |
| Abe, M; Masunaga, S; Ono, K | 1 |
| Abe, M; Akaboshi, M; Akuta, K; Masunaga, S; Ono, K | 1 |
| Guichard, M; Lartigau, E; Simon, JM | 1 |
| Dennis, MF; Hodgkiss, RJ; Johns, H; Rojas, A; Stratford, MR | 1 |
| Fiat, PR; Johns, H; Rojas, AM | 1 |
| Brown, JM; Dorie, MJ; Menke, D | 1 |
| Calvert, AS; Hirst, VK; Johns, H; Rojas, A | 1 |
| Guichard, M; Hodgkiss, RJ; Stern, S | 1 |
| Denekamp, J; Fowler, JF; Johns, H; Joiner, MC; Martindale, C; Rojas, A; Vojnovic, B | 1 |
| Kaanders, JH; Marres, HA; Pop, LA; van Daal, WA; van der Kogel, AJ; van der Maazen, RW | 1 |
| Dische, S; Saunders, M | 1 |
| Abe, M; Akaboshi, M; Akuta, K; Kawai, K; Kinashi, Y; Masunaga, S; Ono, K; Suzuki, M; Takagaki, M | 1 |
| Chaplin, DJ; Guichard, M; Stern, S; Thomas, CD | 1 |
| Duncan, GG; Graham, P; Green, A; Marlow, C; Pickles, T; Rheaume, DE; Syndikus, I | 1 |
| Denekamp, J; Waites, A | 1 |
| Rojas, A | 1 |
| Guichard, M; Stern, S | 1 |
| Caciagli, P; Cartei, F; Colosimo, S; Danesi, R; Del Tacca, M; Ducci, F; Fatigante, L; Laddaga, M; Marini, C; Prediletto, R | 1 |
| Brizel, DM; Dewhirst, MW; Dodge, RK; Hage, WD; Munley, MT; Piantadosi, CA | 1 |
| Hamers, HP; Lambin, P; Menten, J; Poortmans, P | 1 |
| Cladd, H; Goodchild, K; Hoskin, PJ; Phillips, H; Powell, ME; Rojas, A; Saunders, MI; Stratford, MR | 1 |
| Chaplin, DJ; Lam, GK; Ohizumi, Y; Pickles, T | 1 |
| Denekamp, J; Fowler, JF | 1 |
| Hartmann, KA; Schneider, CJ; Sminia, P; Van der Kleij, AJ | 1 |
| Brown, JM; Wouters, BG | 1 |
| Chaplin, DJ; Hill, SA; Hoskin, PJ; Powell, ME; Saunders, MI | 1 |
| Denekamp, J; Dennis, MF; Dische, S; Goodchild, K; Hoskin, PJ; Pigott, K; Powell, ME; Rojas, AM; Saunders, MI; Stratford, MR | 1 |
| Beck-Bornholdt, HP; Krüll, A; Raabe, A; Rett, M | 1 |
| Kaanders, JH; Liefers, J; Marres, HA; Pop, LA; van Daal, WA; van den Hoogen, FJ; van der Kogel, AJ | 1 |
| Bernier, J; Bieri, S; Bolla, M; Denekamp, J; Dennis, MF; Hagen, F; Kocagöncü, O; Rojas, A; Stratford, MR | 1 |
| Booij, J; Bosch, DA; González González, D; Hulshof, MC; Rehmann, CJ; van Royen, EA | 1 |
| Horsman, MR; Knühmann, K; Sack, H; Stüben, G; Stuschke, M | 1 |
| Brauers, G; Chaplin, DJ; Collingridge, DR; Edwards, B; Hill, SA; Honess, DJ; Powell, NA | 1 |
| Bussink, J; Hodgkiss, RJ; Kaanders, JH; Marres, HA; Peters, JP; Rijken, PF; van der Kogel, AJ | 1 |
| Brown, JM; Dorie, MJ; el-Said, A; Menke, D | 1 |
| Bernier, J; Bolla, M; Denekamp, J; Greiner, R; Hulshof, M; Miralbell, R; Mirimanoff, RO; Mornex, F; Pierart, M; Rojas, AM; Storme, G; van Glabbeke, M | 1 |
| Dische, S; Hoskin, PJ; Saunders, MI | 1 |
| Antognoni, P; Bernier, J; Dahl, O; Denekamp, J; Hamers, H; Horiot, JC; Kaanders, J; Piérart, M; Richaud, P; Rojas, A; Trovò, M; van Glabbeke, M | 1 |
| Bussink, J; Kaanders, JH; Van der Kogel, AJ | 2 |
| Fenton, BM; Lord, EM; Paoni, SF | 1 |
| Droller, MJ | 1 |
| Antognoni, P; Bernier, J; Dahl, O; Denekamp, J; Hamers, H; Horiot, J; Minatel, E; Piérart, M; Richaud, P; Rojas, A; van Glabbeke, M | 1 |
| Griffiths, JR; Howe, FA; Robinson, SP; Stubbs, M | 1 |
| Bussink, J; Kaanders, JH; Strik, AM; van der Kogel, AJ | 1 |
| Buchegger, F; Coucke, PA; Mirimanoff, RO; Sun, LQ | 1 |
| Griffin, RJ; Park, H; Song, CW | 1 |
| Braun, RD; Dewhirst, MW; Lanzen, JL; Rosner, G; Turnage, JA | 1 |
| Baas, P; Oppelaar, H; Ruevekamp, M; Schouwink, H; Stewart, FA; van Veen, R | 1 |
| Chiu, RK; Koritzinsky, M; Lambin, P; Landuyt, W; Nuyts, S; Theys, J; Weppler, SA; Wouters, BG | 1 |
| Goodchild, K; Hill, S; Hoskin, PJ; Saunders, M; Shah, N; Sibtain, A | 1 |
| Bruaset, I; Kaanders, JH; Marres, HA; Merkx, MA; Pop, LA; van den Hoogen, FJ; van der Kogel, AJ | 1 |
| Griffiths, JR; Howe, FA; Hui, C; Price, NM; Robinson, SP; Rodrigues, LM; Stubbs, M | 1 |
| Bussink, J; Folkes, LK; Kaanders, JH; Stratford, MR; van der Kogel, AJ | 1 |
| Bussink, J; de Wilde, PC; Kaanders, JH; Ljungkvist, AS; Marres, HA; Pop, LA; Raleigh, JA; van den Hoogen, FJ; van der Kogel, AJ; Wijffels, KI | 1 |
| Dewhirst, MW; Richardson, RA | 1 |
| Baillet, F; Chiras, J; Delattre, JY; Hoang-Xuan, K; Mazeron, JJ; Noël, G; Simon, JM | 1 |
| Horsman, MR; Overgaard, J | 1 |
| Gu, W; Guo, Y; Hang, R; Li, T; Lin, J; Zhang, Y; Zheng, X | 1 |
| Bussink, J; Heerschap, A; Lok, J; Punt, CJ; van Der Kogel, AJ; van Laarhoven, HW | 1 |
| Bentzen, SM; Denekamp, J; Rojas, A; Stratford, MR | 1 |
| Ansiaux, R; Baudelet, C; Gallez, B; Havaux, X; Jordan, BF; Macq, B | 1 |
| Griffiths, JR; Jork, A; Newell, B; Nöth, U; Robinson, SP; Rodrigues, LM; Zimmermann, U | 1 |
| Hoskin, PJ; Phillips, H; Rojas, AM; Saunders, MI | 1 |
| Griffin, RJ; Ogawa, A; Song, CW; Williams, BW | 1 |
| Bussink, J; Heerschap, A; Kaanders, JH; Lok, J; Punt, CJ; van der Kogel, AJ; van Laarhoven, HW; Verhagen, I | 1 |
| Hoogsteen, IJ; Kaanders, JH; Marres, HA; Merkx, MA; Pop, LA; van den Hoogen, FJ; van der Kogel, AJ | 1 |
| Aboagye, EO; Gupta, N; Hoskin, PJ; Jones, T; Kötz, B; Osman, S; Phillips, R; Price, PM; Saleem, A; Vernon, C; Wasan, H | 1 |
| de Wilde, PC; Jonathan, RA; Kaanders, JH; Marres, HA; Merkx, MA; Oosterwijk, E; Peeters, W; van der Kogel, AJ; Wijffels, KI | 1 |
| Hoogsteen, IJ; Kaanders, JH; Marres, HA; van der Kogel, AJ | 1 |
| Chaosu, H; Chunying, S; Xiaoshen, W; Xueguan, L; Yan, F; Yongsheng, Z | 1 |
| Bentzen, SM; Hoskin, PJ; Motohashi, KJ; Rojas, AM; Saunders, MI | 1 |
| Hoskin, P; Rojas, A; Saunders, M | 1 |
| Jones, T; Kötz, B; Price, P; Saleem, A; West, C | 1 |
| Bentzen, SM; Hoskin, PJ; Rojas, AM; Saunders, MI | 1 |
| Bijl, HP; Chin, A; Doornaert, PA; Janssens, GO; Kaanders, JH; Pop, LA; Terhaard, CH; van den Ende, P | 1 |
| Peters, L; Rischin, D | 1 |
| Bijl, HP; Bussink, J; Chin, A; de Bree, R; Doornaert, PA; Hoogsteen, IJ; Janssens, GO; Kaanders, JH; Marres, HA; Rademakers, SE; Span, PN; Terhaard, CH; van den Ende, P; van der Kogel, AJ | 1 |
| Bussink, J; De Bree, R; Doornaert, PA; Hoogsteen, IJ; Kaanders, JH; Langendijk, JA; Oosterwijk, E; Rademakers, SE; Rijken, PF; Takes, R; Terhaard, CH; van den Ende, P; van der Kogel, AJ | 1 |
| Agrawal, S; Choudhury, A; Denley, H; Eustace, A; Harris, AL; Hoskin, PJ; Irlam, JJ; Ord, JJ; Rojas, AM; Ryder, D; Taylor, J; West, CM | 1 |
| Betts, GN; Buffa, FM; Denley, H; Eustace, A; Harris, AL; Homer, JJ; Hoskin, PJ; Irlam, JJ; Kaanders, JH; Mani, N; Miller, CJ; Rojas, AM; Span, PN; Taylor, J; West, CM | 1 |
| Bussink, J; Doornaert, PA; Hoogsteen, IJ; Kaanders, JH; Langendijk, JA; Rademakers, SE; Rijken, PF; Terhaard, CH; van den Ende, P; van der Kogel, AJ | 1 |
| Bijl, HP; de Jong, MA; Doornaert, PA; Janssens, GO; Kaanders, JH; Span, PN; Terhaard, CH; van Bockel, LW; van den Broek, GB; van den Ende, P; Verbist, BM | 1 |
| Bijl, HP; Bussink, J; Chin, A; de Bree, R; Doornaert, PA; Hoogsteen, IJ; Janssens, GO; Kaanders, JH; Rademakers, SE; Span, PN; Takes, RP; Terhaard, CH; van den Ende, P | 1 |
| Bekkers, RL; Bussink, J; Gondhowiardjo, S; Kaanders, JH; Leer, JW; Sekarutami, SM; Span, PN; van Weelden, WJ | 1 |
| Horsman, MR; Wittenborn, TR | 1 |
| de Jong, MA; Doornaert, PA; Janssens, GO; Kaanders, JH; Langendijk, JA; Span, PN; Takes, RP; Terhaard, CH; van den Ende, P | 1 |
| Alsner, J; Buffa, FM; Choudhury, A; Denley, H; Eustace, A; Harris, AL; Hoskin, PJ; Irlam, JJ; Taylor, J; West, CML; Yang, L | 1 |
| Choudhury, A; Hoskin, PJ; Irlam, J; Lane, B; Mistry, H; Song, YP; Valentine, H; West, C; Yang, L | 1 |
| Aragaki, K; Choudhury, A; Dyrskjøt, L; Hoskin, PJ; Irlam-Jones, JJ; Khan, MT; Lane, B; McConkey, DJ; Pereira, RR; Valentine, HR; West, CML | 1 |
| Anzela, A; Azzopardi, M; Barrett, S; Buddle, N; Hooshmand, R; Knesl, M; Min, M; Notman, A; Vignarajah, DD; Wilson, J; Woolls, H | 1 |
7 review(s) available for carbogen and niacinamide
| Article | Year |
|---|---|
Clinical results of hypoxic cell radiosensitisation from hyperbaric oxygen to accelerated radiotherapy, carbogen and nicotinamide.
Topics: Blood Transfusion; Carbon Dioxide; Cell Hypoxia; Humans; Hyperbaric Oxygenation; Neoplasms; Niacinamide; Oxygen; Radiation-Sensitizing Agents | 1996 |
ARCON--current status: summary of a workshop on preclinical and clinical studies.
Topics: Animals; Carbon Dioxide; Cell Division; Cell Hypoxia; Head and Neck Neoplasms; Humans; Neoplasm Recurrence, Local; Neoplasms; Neoplasms, Experimental; Niacinamide; Oxygen; Oxygen Consumption; Radiation-Sensitizing Agents; Radiobiology; Radiotherapy Dosage; Randomized Controlled Trials as Topic; Regional Blood Flow; Urinary Bladder Neoplasms | 1997 |
Improvement of tumor oxygenation by mild hyperthermia.
Topics: Animals; Carbon Dioxide; Cell Hypoxia; Combined Modality Therapy; Dogs; Humans; Hyperthermia, Induced; Mice; Mice, Inbred C3H; Neoplasms; Niacinamide; Oxygen; Partial Pressure; Radiation-Sensitizing Agents; Rats; Regional Blood Flow; Vasodilator Agents; Xenograft Model Antitumor Assays | 2001 |
Hypoxia as a target for combined modality treatments.
Topics: Antineoplastic Combined Chemotherapy Protocols; Carbon Dioxide; Cell Hypoxia; Combined Modality Therapy; Gene Expression; Humans; Neoplasms; Neovascularization, Pathologic; Niacinamide; Oxygen; Prognosis; Radiation-Sensitizing Agents | 2002 |
The importance of tumor metabolism in cancer prognosis and therapy; pre-clinical studies on rodent tumors with agents that improve tumor oxygenation.
Topics: Animals; Blood Glucose; Carbon Dioxide; Humans; Lactic Acid; Magnetic Resonance Imaging; Neoplasms; Niacinamide; Oxygen; Phenotype; Prognosis; Rats | 2002 |
ARCON: a novel biology-based approach in radiotherapy.
Topics: Animals; Carbon Dioxide; Carcinoma; Cell Cycle; Cell Hypoxia; Clinical Trials as Topic; Dose Fractionation, Radiation; Head and Neck Neoplasms; Humans; Mammary Neoplasms, Animal; Mice; Niacinamide; Oxygen; Patient Selection; Radiation-Sensitizing Agents; Radiotherapy; Urinary Bladder Neoplasms | 2002 |
The hypoxic tumour microenvironment, patient selection and hypoxia-modifying treatments.
Topics: Anemia; Biomarkers, Tumor; Carbon Dioxide; Cell Hypoxia; Humans; Hyperbaric Oxygenation; Neoplasms; Niacinamide; Nuclear Medicine; Oxygen; Patient Selection; Radiation Tolerance; Radiation-Sensitizing Agents; Vitamin B Complex | 2007 |
30 trial(s) available for carbogen and niacinamide
| Article | Year |
|---|---|
Pharmacokinetics of nicotinamide and its effect on blood pressure, pulse and body temperature in normal human volunteers.
Topics: Administration, Oral; Adult; Blood Pressure; Body Temperature; Carbon Dioxide; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; Female; Humans; Male; Niacinamide; Oxygen; Pulse; Radiation-Sensitizing Agents | 1992 |
Tolerance of nicotinamide and carbogen with radiation therapy for glioblastoma.
Topics: Administration, Inhalation; Administration, Oral; Adolescent; Adult; Aged; Animals; Carbon Dioxide; Combined Modality Therapy; Drug Tolerance; Female; Glioblastoma; Humans; Liver; Male; Middle Aged; Niacinamide; Oxygen; Prospective Studies; Radiotherapy Dosage; Rats; Treatment Outcome | 1996 |
Carbogen and nicotinamide in the treatment of bladder cancer with radical radiotherapy.
Topics: Aged; Carbon Dioxide; Carcinoma; Chemotherapy, Adjuvant; Cohort Studies; Female; Humans; Male; Middle Aged; Niacinamide; Oxygen; Radiation-Sensitizing Agents; Radiotherapy, Adjuvant; Treatment Outcome; Urinary Bladder Neoplasms; Urination | 1997 |
Human tumor blood flow is enhanced by nicotinamide and carbogen breathing.
Topics: Administration, Inhalation; Administration, Oral; Carbon Dioxide; Female; Humans; Laser-Doppler Flowmetry; Microcirculation; Neoplasms; Niacinamide; Oxygen; Perfusion; Regional Blood Flow | 1997 |
Accelerated radiotherapy, carbogen and nicotinamide (ARCON) in locally advanced head and neck cancer: a feasibility study.
Topics: Administration, Oral; Aerosols; Antiemetics; Carbon Dioxide; Disease-Free Survival; Dose Fractionation, Radiation; Dose-Response Relationship, Radiation; Feasibility Studies; Head and Neck Neoplasms; Humans; Metoclopramide; Nausea; Niacinamide; Oxygen; Radiation-Sensitizing Agents; Radiotherapy, High-Energy; Vomiting | 1997 |
Pharmacokinetics of nicotinamide in cancer patients treated with accelerated radiotherapy: the experience of the Co-operative Group of Radiotherapy of the European Organization for Research and Treatment of Cancer.
Topics: Administration, Oral; Area Under Curve; Carbon Dioxide; Carcinoma; Carcinoma, Non-Small-Cell Lung; Cell Hypoxia; Dose Fractionation, Radiation; Follow-Up Studies; Half-Life; Head and Neck Neoplasms; Humans; Lung Neoplasms; Nausea; Niacinamide; Oxygen; Pyridones; Radiation-Sensitizing Agents; Tablets; Time Factors; Treatment Outcome; Vomiting | 1998 |
Lack of perfusion enhancement after administration of nicotinamide and carbogen in patients with glioblastoma: a 99mTc-HMPAO SPECT study.
Topics: Analysis of Variance; Brain Neoplasms; Carbon Dioxide; Cell Hypoxia; Cerebrovascular Circulation; Glioblastoma; Humans; Image Enhancement; Image Processing, Computer-Assisted; Niacinamide; Oxygen; Radiation-Sensitizing Agents; Radiopharmaceuticals; Regional Blood Flow; Technetium Tc 99m Exametazime; Tomography, Emission-Computed, Single-Photon | 1998 |
Accelerated radiotherapy, carbogen, and nicotinamide in glioblastoma multiforme: report of European Organization for Research and Treatment of Cancer trial 22933.
Topics: Administration, Inhalation; Administration, Oral; Adult; Aged; Brain Neoplasms; Carbon Dioxide; Cell Division; Cell Hypoxia; Dose Fractionation, Radiation; Female; Glioblastoma; Humans; Male; Middle Aged; Niacinamide; Oxygen; Radiation-Sensitizing Agents; Survival Analysis; Treatment Outcome | 1999 |
Hypoxic radiosensitizers in radical radiotherapy for patients with bladder carcinoma: hyperbaric oxygen, misonidazole, and accelerated radiotherapy, carbogen, and nicotinamide.
Topics: Adult; Aged; Carbon Dioxide; Humans; Hyperbaric Oxygenation; Middle Aged; Misonidazole; Niacinamide; Oxygen; Radiation-Sensitizing Agents; Radiotherapy Dosage; Urinary Bladder Neoplasms | 1999 |
ARCON: accelerated radiotherapy with carbogen and nicotinamide in non small cell lung cancer: a phase I/II study by the EORTC.
Topics: Administration, Inhalation; Administration, Oral; Adult; Aged; Carbon Dioxide; Carcinoma, Non-Small-Cell Lung; Dose Fractionation, Radiation; Humans; Lung Neoplasms; Middle Aged; Niacinamide; Oxygen; Pilot Projects; Radiation-Sensitizing Agents; Radiotherapy Dosage; Radiotherapy, High-Energy | 1999 |
ARCON: accelerated radiotherapy with carbogen and nicotinamide in head and neck squamous cell carcinomas. The experience of the Co-operative group of radiotherapy of the european organization for research and treatment of cancer (EORTC).
Topics: Adult; Aged; Carbon Dioxide; Carcinoma, Squamous Cell; Dose Fractionation, Radiation; Head and Neck Neoplasms; Humans; Middle Aged; Niacinamide; Oxygen; Patient Compliance; Radiotherapy | 2000 |
ARCON: experience in 215 patients with advanced head-and-neck cancer.
Topics: Adult; Aged; Aged, 80 and over; Carbon Dioxide; Dose Fractionation, Radiation; Feasibility Studies; Female; Head and Neck Neoplasms; Humans; Hypoxia; Male; Middle Aged; Niacinamide; Oxygen; Radiation Injuries; Radiation-Sensitizing Agents | 2002 |
Pimonidazole binding and tumor vascularity predict for treatment outcome in head and neck cancer.
Topics: Adult; Aged; Aged, 80 and over; Antigens, Neoplasm; Carbon Dioxide; Carbonic Anhydrase IX; Carbonic Anhydrases; Carcinoma, Squamous Cell; Cell Hypoxia; Combined Modality Therapy; Female; Head and Neck Neoplasms; Humans; Male; Middle Aged; Neoplasm Proteins; Niacinamide; Nitroimidazoles; Oxygen; Predictive Value of Tests; Treatment Outcome | 2002 |
Radiotherapy and chemotherapy with or without carbogen and nicotinamide in inoperable biopsy-proven glioblastoma multiforme.
Topics: Adult; Aged; Biopsy; Brain; Brain Neoplasms; Carbon Dioxide; Chi-Square Distribution; Combined Modality Therapy; Computer Graphics; Drug Therapy, Combination; Female; Glioblastoma; Humans; Male; Middle Aged; Niacinamide; Oxygen; Proportional Hazards Models; Radiation-Sensitizing Agents; Retrospective Studies; Statistics, Nonparametric; Survival Analysis | 2003 |
Acute and late morbidity in the treatment of advanced bladder carcinoma with accelerated radiotherapy, carbogen, and nicotinamide.
Topics: Adult; Aged; Aged, 80 and over; Carbon Dioxide; Carcinoma, Squamous Cell; Carcinoma, Transitional Cell; Cell Hypoxia; Combined Modality Therapy; Disease-Free Survival; Humans; Middle Aged; Niacinamide; Oxygen; Radiotherapy, High-Energy; Survival Rate; Urinary Bladder Neoplasms | 2005 |
Oxygen-modifying treatment with ARCON reduces the prognostic significance of hemoglobin in squamous cell carcinoma of the head and neck.
Topics: Administration, Inhalation; Adult; Aged; Aged, 80 and over; Carbon Dioxide; Carcinoma, Squamous Cell; Cell Hypoxia; Female; Head and Neck Neoplasms; Hemoglobins; Humans; Male; Middle Aged; Multivariate Analysis; Niacinamide; Oxygen; Prognosis; Radiation-Sensitizing Agents; Sex Factors; Treatment Outcome | 2006 |
Carbogen and nicotinamide increase blood flow and 5-fluorouracil delivery but not 5-fluorouracil retention in colorectal cancer metastases in patients.
Topics: Administration, Inhalation; Administration, Oral; Aged; Antimetabolites, Antineoplastic; Carbon Dioxide; Colorectal Neoplasms; Drug Interactions; Female; Fluorouracil; Humans; Liver Neoplasms; Male; Middle Aged; Niacinamide; Oxygen; Radiation-Sensitizing Agents; Regional Blood Flow; Tissue Distribution; Vitamin B Complex | 2006 |
Carbogen and nicotinamide in locally advanced bladder cancer: early results of a phase-III randomized trial.
Topics: Aged; Aged, 80 and over; Carbon Dioxide; Carcinoma, Transitional Cell; Dose Fractionation, Radiation; Female; Humans; Male; Middle Aged; Neoplasm Invasiveness; Niacinamide; Oxygen; Radiation-Sensitizing Agents; Radiotherapy Dosage; Treatment Outcome; Urinary Bladder Neoplasms | 2009 |
Accelerated radiotherapy, carbogen, and nicotinamide (ARCON) in the treatment of advanced bladder cancer: mature results of a Phase II nonrandomized study.
Topics: Adult; Aged; Aged, 80 and over; Carbon Dioxide; Carcinoma in Situ; Cystectomy; Dose Fractionation, Radiation; Feasibility Studies; Female; Humans; Male; Middle Aged; Neoplasm Staging; Niacinamide; Oxygen; Radiation-Sensitizing Agents; Remission Induction; Survival Rate; Urinary Bladder Neoplasms | 2009 |
Radiotherapy with concurrent carbogen and nicotinamide in bladder carcinoma.
Topics: Aged; Aged, 80 and over; Carbon Dioxide; Cystectomy; Female; Humans; Male; Middle Aged; Neoplasm Staging; Niacinamide; Oxygen; Radiation-Sensitizing Agents; Urinary Bladder Neoplasms | 2010 |
Acute toxicity profile and compliance to accelerated radiotherapy plus carbogen and nicotinamide for clinical stage T2-4 laryngeal cancer: results of a phase III randomized trial.
Topics: Adult; Aged; Aged, 80 and over; Analgesics, Opioid; Carbon Dioxide; Carcinoma, Squamous Cell; Deglutition Disorders; Female; Humans; Intubation, Gastrointestinal; Laryngeal Neoplasms; Male; Middle Aged; Neoplasm Staging; Netherlands; Niacinamide; Oxygen; Patient Compliance; Radiation-Sensitizing Agents; Radiodermatitis; Stomatitis; Vitamin B Complex | 2012 |
Accelerated radiotherapy with carbogen and nicotinamide for laryngeal cancer: results of a phase III randomized trial.
Topics: Administration, Inhalation; Administration, Oral; Adult; Aged; Aged, 80 and over; Biomarkers, Tumor; Carbon Dioxide; Carcinoma, Squamous Cell; Chi-Square Distribution; Disease-Free Survival; Dose Fractionation, Radiation; Female; Humans; Kaplan-Meier Estimate; Laryngeal Neoplasms; Male; Middle Aged; Netherlands; Niacinamide; Oxygen; Patient Selection; Proportional Hazards Models; Radiation-Sensitizing Agents; Risk Assessment; Risk Factors; Time Factors; Treatment Outcome; United Kingdom; Vitamin B Complex | 2012 |
Pattern of CAIX expression is prognostic for outcome and predicts response to ARCON in patients with laryngeal cancer treated in a phase III randomized trial.
Topics: Adult; Aged; Aged, 80 and over; Antigens, Neoplasm; Carbon Dioxide; Carbonic Anhydrase IX; Carbonic Anhydrases; Female; Humans; Laryngeal Neoplasms; Male; Middle Aged; Niacinamide; Nitroimidazoles; Oxygen; Prognosis; Treatment Outcome | 2013 |
Necrosis predicts benefit from hypoxia-modifying therapy in patients with high risk bladder cancer enrolled in a phase III randomised trial.
Topics: Aged; Aged, 80 and over; Carbon Dioxide; Carbonic Anhydrase IV; Cell Hypoxia; Female; Glucose Transporter Type 1; Humans; Male; Middle Aged; Necrosis; Niacinamide; Oxygen; Risk; Urinary Bladder Neoplasms | 2013 |
A 26-gene hypoxia signature predicts benefit from hypoxia-modifying therapy in laryngeal cancer but not bladder cancer.
Topics: Carbon Dioxide; Cell Hypoxia; Female; Gene Expression Regulation, Neoplastic; Humans; Laryngeal Neoplasms; Male; Niacinamide; Oxygen; Radiation-Sensitizing Agents; Urinary Bladder Neoplasms | 2013 |
Prognostic value of the proliferation marker Ki-67 in laryngeal carcinoma: results of the accelerated radiotherapy with carbogen breathing and nicotinamide phase III randomized trial.
Topics: Administration, Inhalation; Adult; Aged; Aged, 80 and over; Antigens, Neoplasm; Carbon Dioxide; Carbonic Anhydrase IX; Carbonic Anhydrases; Carcinoma, Squamous Cell; Female; Humans; Immunohistochemistry; Ki-67 Antigen; Laryngeal Neoplasms; Male; Middle Aged; Neoplasm Metastasis; Niacinamide; Oxygen; Prognosis; Radiation-Sensitizing Agents; Vitamin B Complex | 2015 |
Improved recurrence-free survival with ARCON for anemic patients with laryngeal cancer.
Topics: Adult; Aged; Aged, 80 and over; Anemia; Biomarkers; Carbon Dioxide; Female; Hemoglobins; Humans; Hypoxia; Laryngeal Neoplasms; Male; Middle Aged; Neoplasm Staging; Niacinamide; Oxygen; Prognosis; Radiation-Sensitizing Agents; Radiotherapy; Treatment Outcome | 2014 |
Quality-of-life after radiotherapy for advanced laryngeal cancer: Results of a phase III trial of the Dutch Head and Neck Society.
Topics: Adult; Aged; Aged, 80 and over; Carbon Dioxide; Female; Follow-Up Studies; Head and Neck Neoplasms; Humans; Laryngeal Neoplasms; Male; Middle Aged; Netherlands; Niacinamide; Oxygen; Quality of Life; Radiation-Sensitizing Agents; Societies, Medical; Surveys and Questionnaires | 2016 |
Long-Term Outcomes of Radical Radiation Therapy with Hypoxia Modification with Biomarker Discovery for Stratification: 10-Year Update of the BCON (Bladder Carbogen Nicotinamide) Phase 3 Randomized Trial (ISRCTN45938399).
Topics: Adult; Aged; Aged, 80 and over; Biomarkers, Tumor; Carbon Dioxide; Confidence Intervals; Disease-Free Survival; Female; Follow-Up Studies; Humans; Male; Middle Aged; Necrosis; Niacinamide; Oxygen; Radiation-Sensitizing Agents; Regression Analysis; Survival Rate; Time Factors; Treatment Outcome; Tumor Hypoxia; Urinary Bladder Neoplasms | 2021 |
A miRNA signature predicts benefit from addition of hypoxia-modifying therapy to radiation treatment in invasive bladder cancer.
Topics: Biomarkers, Tumor; Carbon Dioxide; Cell Hypoxia; Cell Line, Tumor; Cell Proliferation; Cell Survival; Chemoradiotherapy; Gene Expression Regulation, Neoplastic; Humans; MicroRNAs; Niacinamide; Oligonucleotide Array Sequence Analysis; Oxygen; Prognosis; Survival Analysis; Urinary Bladder Neoplasms | 2021 |
78 other study(ies) available for carbogen and niacinamide
| Article | Year |
|---|---|
Carbogen and nicotinamide: expectations too high? (response to J. Martin Brown)
Topics: Animals; Carbon Dioxide; Humans; Mice; Neoplasms; Neoplasms, Experimental; Niacinamide; Oxygen; Radiation-Sensitizing Agents | 1992 |
Extrapolations from laboratory and preclinical studies for the use of carbogen and nicotinamide in radiotherapy.
Topics: Animals; Carbon Dioxide; Humans; Mice; Neoplasms; Neoplasms, Experimental; Niacinamide; Oxygen; Radiation-Sensitizing Agents | 1992 |
Carbogen and nicotinamide: expectations too high?
Topics: Animals; Carbon Dioxide; Humans; Mice; Neoplasms; Neoplasms, Experimental; Niacinamide; Oxygen; Radiation-Sensitizing Agents | 1992 |
Nicotinamide, Fluosol DA and Carbogen: a strategy to reoxygenate acutely and chronically hypoxic cells in vivo.
Topics: Animals; Carbon Dioxide; Carcinoma, Small Cell; Cell Hypoxia; Cell Survival; Dose-Response Relationship, Radiation; Drug Combinations; Drug Therapy, Combination; Female; Fluorocarbons; Hydroxyethyl Starch Derivatives; Mice; Mice, Inbred Strains; Neoplasm Transplantation; Neoplasms, Experimental; Niacinamide; Oxygen; Radiation-Sensitizing Agents; Sarcoma, Experimental | 1991 |
Short communication: the addition of carbogen and nicotinamide to a palliative fractionation schedule for locally advanced breast cancer.
Topics: Aged; Aged, 80 and over; Breast Neoplasms; Carbon Dioxide; Female; Humans; Middle Aged; Niacinamide; Oxygen; Palliative Care; Pilot Projects; Radiation-Sensitizing Agents; Radiotherapy | 1995 |
Conventional radiotherapy combined with carbogen breathing and nicotinamide for malignant gliomas.
Topics: Administration, Inhalation; Aged; Brain Neoplasms; Carbon Dioxide; Combined Modality Therapy; Female; Glioma; Humans; Male; Middle Aged; Niacinamide; Oxygen; Radiation Injuries; Radiation-Sensitizing Agents | 1995 |
The combination of nicotinamide and carbogen breathing to improve tumour oxygenation prior to radiation treatment.
Topics: Animals; Carbon Dioxide; Combined Modality Therapy; Female; Mammary Neoplasms, Experimental; Mice; Mice, Inbred C3H; Niacinamide; Oxygen; Oxygen Consumption; Radiation Tolerance; Radiation-Sensitizing Agents; Respiration | 1994 |
Carbogen breathing with nicotinamide improves the oxygen status of tumours in patients.
Topics: Adult; Aged; Aged, 80 and over; Carbon Dioxide; Female; Humans; Male; Middle Aged; Neoplasms; Niacinamide; Oxygen; Partial Pressure; Radiation-Sensitizing Agents | 1995 |
The effects of carbogen and nicotinamide on intravascular oxyhaemoglobin saturations in SCCVII and KHT murine tumours.
Topics: Animals; Carbon Dioxide; Carcinoma, Squamous Cell; Cell Hypoxia; Female; Mice; Mice, Inbred C3H; Neoplasm Transplantation; Niacinamide; Oxygen; Oxyhemoglobins; Partial Pressure; Radiation Tolerance; Radiation-Sensitizing Agents; Sarcoma, Experimental; Tumor Cells, Cultured | 1995 |
Tumour oxygenation, radiosensitivity, and necrosis before and/or after nicotinamide, carbogen and perflubron emulsion administration.
Topics: Animals; Carbon Dioxide; Cell Survival; Fluorocarbons; Humans; Hydrocarbons, Brominated; Hypoxia; Mice; Necrosis; Niacinamide; Oxygen; Tumor Cells, Cultured | 1995 |
Are direct measures of tumor oxygenation reflective of changes in tumor radiosensitivity following oxygen manipulation?
Topics: Animals; Carbon Dioxide; Cell Survival; Female; Mice; Mice, Inbred C3H; Niacinamide; Oxygen; Oxyhemoglobins; Radiation-Sensitizing Agents; Radiotherapy Dosage; Sarcoma, Experimental | 1995 |
Reoxygenation in a C3H mouse mammary carcinoma. The importance of chronic rather than acute hypoxia.
Topics: Animals; Carbon Dioxide; Cell Hypoxia; Female; Mammary Neoplasms, Experimental; Mice; Mice, Inbred C3H; Mice, Inbred Strains; Niacinamide; Oxygen; Oxygen Consumption; Radiation-Sensitizing Agents; Radiotherapy Dosage; Time Factors | 1995 |
Perfusion changes in the RIF-1 tumour and normal tissues after carbogen and nicotinamide, individually and combined.
Topics: Administration, Inhalation; Animals; Body Temperature; Carbon Dioxide; Cell Hypoxia; Drug Interactions; Female; Mice; Mice, Inbred C3H; Neoplasms, Experimental; Niacinamide; Oxygen; Perfusion; Radiation-Sensitizing Agents; Regional Blood Flow; Rubidium | 1995 |
ARCON.
Topics: Animals; Carbon Dioxide; Humans; Neoplasms; Niacinamide; Oxygen; Radiation-Sensitizing Agents; Radiotherapy; Radiotherapy Dosage | 1994 |
Nicotinamide and carbogen: relationship between pO2 and radiosensitivity in three tumour lines.
Topics: Animals; Carbon Dioxide; Cell Survival; Humans; Mice; Niacinamide; Oxygen; Radiation Tolerance; Radiation-Sensitizing Agents; Tumor Cells, Cultured | 1994 |
[The effect of nicotinamide and carbogen on the radiation tolerance of the spinal cord of the rat].
Topics: Animals; Carbon Dioxide; Niacinamide; Oxygen; Radiation Tolerance; Radiation-Sensitizing Agents; Rats; Spinal Cord | 1994 |
Reducing acute and chronic hypoxia in tumours by combining nicotinamide with carbogen breathing.
Topics: Animals; Carbon Dioxide; Cell Hypoxia; Female; Mammary Neoplasms, Experimental; Mice; Niacinamide; Oxygen; Partial Pressure; Radiation-Sensitizing Agents | 1994 |
Acute effects of accelerated radiotherapy in combination with carbogen breathing and nicotinamide (ARCON).
Topics: Administration, Inhalation; Aged; Carbon Dioxide; Carcinoma, Squamous Cell; Head and Neck Neoplasms; Humans; Male; Middle Aged; Niacinamide; Oxygen; Pilot Projects; Radiation-Sensitizing Agents | 1994 |
The radiation response of KHT sarcomas following nicotinamide treatment and carbogen breathing.
Topics: Administration, Inhalation; Animals; Carbon Dioxide; Cell Hypoxia; Cell Survival; Combined Modality Therapy; Dose-Response Relationship, Radiation; Drug Therapy, Combination; Female; Mice; Mice, Inbred C3H; Neoplasm Transplantation; Niacinamide; Oxygen; Radiation Dosage; Radiation-Sensitizing Agents; Sarcoma, Experimental; Tumor Cells, Cultured | 1994 |
Influence of combined use of nicotinamide and carbogen on rat spinal cord radiation tolerance.
Topics: Administration, Inhalation; Animals; Carbon Dioxide; Dose-Response Relationship, Drug; Dose-Response Relationship, Radiation; Drug Therapy, Combination; Male; Niacinamide; Oxygen; Radiation Tolerance; Radiation-Sensitizing Agents; Rats; Rats, Inbred Strains; Spinal Cord | 1994 |
Middle dose rate irradiation in combination with carbogen inhalation selectively and more markedly increases the responses of SCCVII tumors.
Topics: Animals; Bone Marrow; Carbon Dioxide; Cell Survival; DNA Damage; Intestines; Male; Mice; Mice, Inbred C3H; Micronucleus Tests; Neoplasms, Experimental; Niacinamide; Oxygen; Radiation-Sensitizing Agents; Radiotherapy Dosage | 1994 |
The detection and modification of the hypoxic fraction in quiescent cell populations in murine solid tumours.
Topics: Animals; Carbon Dioxide; Carcinoma, Squamous Cell; Cell Survival; Female; Mice; Mice, Inbred BALB C; Mice, Inbred C3H; Niacinamide; Oxygen; Radiation Tolerance; Radiation-Sensitizing Agents; Sarcoma; Tumor Cells, Cultured | 1993 |
Radiosensitization of SCCVII tumours and normal tissues by nicotinamide and carbogen: analysis by micronucleus assay.
Topics: Animals; Carbon Dioxide; Carcinoma, Squamous Cell; Dose-Response Relationship, Drug; Drug Therapy, Combination; Male; Mice; Mice, Inbred C3H; Micronucleus Tests; Niacinamide; Oxygen; Radiation Tolerance; Radiation-Sensitizing Agents | 1993 |
Nicotinamide and carbogen: major effect on the radiosensitivity of EMT6 and HRT18 tumours.
Topics: Animals; Carbon Dioxide; Cell Survival; Female; Humans; Mice; Mice, Nude; Neoplasm Transplantation; Neoplasms, Experimental; Niacinamide; Oxygen; Radiation Dosage; Radiation Tolerance; Radiation-Sensitizing Agents; Tumor Cells, Cultured | 1993 |
Pharmacokinetics of varying doses of nicotinamide and tumour radiosensitisation with carbogen and nicotinamide: clinical considerations.
Topics: Adenocarcinoma; Animals; Carbon Dioxide; Cell Hypoxia; Cell Survival; Dose-Response Relationship, Drug; Least-Squares Analysis; Male; Mammary Neoplasms, Experimental; Mice; Mice, Inbred CBA; Niacinamide; Oxygen; Radiation-Sensitizing Agents | 1993 |
Should carbogen and nicotinamide be given throughout the full course of fractionated radiotherapy regimens?
Topics: Adenocarcinoma; Animals; Carbon Dioxide; Male; Mammary Neoplasms, Experimental; Mice; Mice, Inbred CBA; Niacinamide; Oxygen; Radiation-Sensitizing Agents; Radiotherapy; Radiotherapy Dosage; X-Rays | 1993 |
Comparison of the enhancement of tumor responses to fractionated irradiation by SR 4233 (tirapazamine) and by nicotinamide with carbogen.
Topics: Animals; Antineoplastic Agents; Carbon Dioxide; Combined Modality Therapy; Drug Combinations; Mice; Mice, Inbred C3H; Neoplasms, Experimental; Niacinamide; Oxygen; Radiation-Sensitizing Agents; Tirapazamine; Triazines | 1994 |
Further evaluation of nicotinamide and carbogen as a strategy to reoxygenate hypoxic cells in vivo: importance of nicotinamide dose and pre-irradiation breathing time.
Topics: Administration, Inhalation; Animals; Carbon Dioxide; Cell Hypoxia; Dose-Response Relationship, Drug; Dose-Response Relationship, Radiation; Female; Injections, Intraperitoneal; Mice; Mice, Inbred C3H; Neoplasms, Experimental; Niacinamide; Oxygen; Radiation-Sensitizing Agents | 1993 |
Carbogen and nicotinamide as radiosensitizers in a murine mammary carcinoma using conventional and accelerated radiotherapy.
Topics: Animals; Body Weight; Carbon Dioxide; Dose-Response Relationship, Radiation; Male; Mammary Neoplasms, Experimental; Mice; Mice, Inbred CBA; Niacinamide; Oxygen; Radiation Tolerance; Radiation-Sensitizing Agents; Radiotherapy Dosage | 1996 |
Comparison of two techniques for detecting tumour hypoxia: a fluorescent immunochemical method and an in vitro colony assay.
Topics: Adenocarcinoma; Animals; Carbon Dioxide; Cell Hypoxia; Cell Survival; Cesium Radioisotopes; DNA Damage; DNA, Neoplasm; Drug Combinations; Emulsions; Female; Fluorescent Antibody Technique, Indirect; Fluorocarbons; Humans; Hydrocarbons, Brominated; Mammary Neoplasms, Animal; Mice; Mice, Nude; Niacinamide; Nitroimidazoles; Oxygen; Radiation-Sensitizing Agents; Rectal Neoplasms; Theophylline; Tumor Cells, Cultured; Tumor Stem Cell Assay | 1996 |
Radiosensitisation in normal tissues with oxygen, carbogen or nicotinamide: therapeutic gain comparisons for fractionated x-ray schedules.
Topics: Animals; Carbon Dioxide; Chromium Radioisotopes; Dose-Response Relationship, Radiation; Drug Combinations; Edetic Acid; Female; Hematocrit; Intestinal Mucosa; Kidney; Lung; Metabolic Clearance Rate; Mice; Mice, Inbred CBA; Mice, Inbred Strains; Niacinamide; Oxygen; Radiation Tolerance; Radiation-Sensitizing Agents; Radiotherapy Dosage; Respiration; Skin; X-Ray Therapy | 1996 |
Radiotherapy with carbogen breathing and nicotinamide in head and neck cancer: feasibility and toxicity.
Topics: Administration, Inhalation; Administration, Oral; Adult; Aged; Aged, 80 and over; Carbon Dioxide; Carcinoma, Mucoepidermoid; Carcinoma, Squamous Cell; Feasibility Studies; Female; Humans; Hypopharyngeal Neoplasms; Laryngeal Neoplasms; Male; Middle Aged; Mouth Neoplasms; Neoplasm Staging; Niacinamide; Oropharyngeal Neoplasms; Oxygen; Palliative Care; Radiation Injuries; Radiation-Sensitizing Agents; Radiotherapy Dosage | 1995 |
An attempt to enhance chemosensitivity of quiescent cell populations in solid tumors by combined treatment with nicotinamide and carbogen.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Carbon Dioxide; Carcinoma, Squamous Cell; Cell Division; Cell Hypoxia; Cisplatin; Drug Screening Assays, Antitumor; Drug Synergism; Mice; Mice, Inbred BALB C; Mice, Inbred C3H; Micronuclei, Chromosome-Defective; Niacinamide; Oxygen; Sarcoma, Experimental | 1996 |
Transient perfusion and radiosensitizing effect after nicotinamide, carbogen, and perflubron emulsion administration.
Topics: Adenocarcinoma; Animals; Carbon Dioxide; Emulsions; Female; Fluorocarbons; Humans; Hydrocarbons, Brominated; Melanoma; Mice; Mice, Nude; Microscopy, Fluorescence; Neoplasm Transplantation; Niacinamide; Oxygen; Perfusion; Radiation-Sensitizing Agents; Rectal Neoplasms; Regional Blood Flow; Sensitivity and Specificity; Tumor Cells, Cultured | 1996 |
The potential for improving radiotherapy outcome by improving the oxygen supply to solid tumours.
Topics: Animals; Carbon Dioxide; Cell Hypoxia; Cells, Cultured; Humans; Mice; Neoplasms; Neoplasms, Experimental; Niacinamide; Oxygen; Radiation-Sensitizing Agents; Radiotherapy Dosage | 1996 |
ARCON.
Topics: Animals; Carbon Dioxide; Cell Hypoxia; Humans; Mice; Neoplasms; Neoplasms, Experimental; Niacinamide; Oxygen; Radiation-Sensitizing Agents; Time Factors | 1996 |
Efficacy of agents counteracting hypoxia in fractionated radiation regimes.
Topics: Adenocarcinoma; Animals; Carbon Dioxide; Cell Hypoxia; Emulsions; Female; Fluorocarbons; Humans; Hydrocarbons, Brominated; Mammary Neoplasms, Experimental; Mice; Niacinamide; Oxygen; Radiation Tolerance; Radiation-Sensitizing Agents; Radiotherapy; Radiotherapy Dosage; Rectal Neoplasms; Tirapazamine; Triazines; Tumor Cells, Cultured | 1996 |
Carbogen and nicotinamide combined with unconventional radiotherapy in glioblastoma multiforme: a new modality treatment.
Topics: Administration, Inhalation; Adult; Aged; Carbon Dioxide; Combined Modality Therapy; Female; Glioblastoma; Humans; Male; Middle Aged; Niacinamide; Oxygen; Radiation-Sensitizing Agents; Radiotherapy Dosage; Supratentorial Neoplasms; Survival Rate | 1997 |
Tolerance to nicotinamide and carbogen with radiation therapy for glioblastoma.
Topics: Carbon Dioxide; Glioblastoma; Humans; Niacinamide; Oxygen; Radiation-Sensitizing Agents | 1997 |
Hyperbaric oxygen improves tumor radiation response significantly more than carbogen/nicotinamide.
Topics: Animals; Carbon Dioxide; Female; Hyperbaric Oxygenation; Neoplasms, Experimental; Niacinamide; Oxygen; Rats; Rats, Inbred F344 | 1997 |
Accelerated radiotherapy with carbogen and nicotinamide (ARCON) in high grade malignant gliomas.
Topics: Brain Neoplasms; Carbon Dioxide; Combined Modality Therapy; Glioma; Humans; Niacinamide; Oxygen; Radiation-Sensitizing Agents | 1997 |
Early skin response to fractionated doses of pions for determining therapeutic gain factors.
Topics: Animals; Carbon Dioxide; Cell Hypoxia; Combined Modality Therapy; Dose-Response Relationship, Radiation; Female; Mesons; Mice; Mice, Inbred C3H; Neoplasms, Experimental; Niacinamide; Oxygen; Radiation-Sensitizing Agents; Relative Biological Effectiveness; Skin | 1996 |
Is hyperbaric oxygen more effective than carbogen/nicotinamide in tumor radiation response?
Topics: Animals; Carbon Dioxide; Hyperbaric Oxygenation; Hypoxia; Neoplasms, Experimental; Niacinamide; Oxygen; Radiation-Sensitizing Agents; Rats | 1997 |
Comments on hyperbaric oxygen and carbogen/nicotinamide with fractionated radiation.
Topics: Carbon Dioxide; Humans; Hyperbaric Oxygenation; Hypoxia; Models, Biological; Neoplasms; Niacinamide; Oxygen; Radiotherapy; Radiotherapy Dosage | 1997 |
Combination of fractionated irradiation with nicotinamide and carbogen in R1H-tumours of the rat and its pulmonary metastases.
Topics: Animals; Carbon Dioxide; Combined Modality Therapy; Disease Models, Animal; Dose Fractionation, Radiation; Dose-Response Relationship, Drug; Female; Lung; Lung Neoplasms; Neoplasm Recurrence, Local; Neoplasms, Experimental; Niacinamide; Oxygen; Radiation-Sensitizing Agents; Rats; Rhabdomyosarcoma; Skin Neoplasms; Treatment Outcome | 1997 |
Accelerated radiotherapy with carbogen and nicotinamide (ARCON) for laryngeal cancer.
Topics: Actuarial Analysis; Administration, Inhalation; Administration, Oral; Adult; Aged; Aged, 80 and over; Carbon Dioxide; Carcinoma; Cell Division; Cell Hypoxia; Dose Fractionation, Radiation; Feasibility Studies; Female; Follow-Up Studies; Humans; Laryngeal Neoplasms; Laryngectomy; Lymphatic Metastasis; Male; Middle Aged; Neoplasm Recurrence, Local; Neoplasm Staging; Niacinamide; Oxygen; Prospective Studies; Radiation-Sensitizing Agents; Radiotherapy Dosage; Salvage Therapy; Survival Rate | 1998 |
The effect of combined nicotinamide and carbogen treatments in human tumour xenografts: oxygenation and tumour control studies.
Topics: Administration, Inhalation; Animals; Carbon Dioxide; Cell Hypoxia; Drug Combinations; Glioblastoma; Humans; Injections, Intraperitoneal; Mice; Mice, Nude; Neoplasm Transplantation; Neurofibrosarcoma; Niacinamide; Oxygen; Oxygen Consumption; Radiation-Sensitizing Agents; Radiotherapy Dosage; Sarcoma; Sarcoma, Experimental; Skin Neoplasms; Transplantation, Heterologous | 1998 |
Preclinical evaluation of the novel hypoxic marker 99mTc-HL91 (Prognox) in murine and xenograft systems in vivo.
Topics: Adenocarcinoma; Animals; Carbon Dioxide; Carcinoma; Cell Hypoxia; Colonic Neoplasms; Contrast Media; Humans; Lung Neoplasms; Mice; Mice, Inbred CBA; Mice, SCID; Niacinamide; Organotechnetium Compounds; Oximes; Oxygen; Radiopharmaceuticals; Sarcoma | 1998 |
Vascular architecture and microenvironmental parameters in human squamous cell carcinoma xenografts: effects of carbogen and nicotinamide.
Topics: Animals; Benzimidazoles; Blood Vessels; Carbon Dioxide; Carcinoma, Squamous Cell; Cell Division; Endothelium, Vascular; Humans; Hypoxia; Laryngeal Neoplasms; Mice; Mice, Nude; Neoplasm Transplantation; Niacinamide; Nitroimidazoles; Oxygen; Radiation-Sensitizing Agents; Theophylline; Transplantation, Heterologous; Tumor Cells, Cultured | 1999 |
Comparison of the effectiveness of tirapazamine and carbogen with nicotinamide in enhancing the response of a human tumor xenograft to fractionated irradiation.
Topics: Animals; Carbon Dioxide; Carcinoma, Squamous Cell; Cell Survival; Chemotherapy, Adjuvant; Combined Modality Therapy; Disease Models, Animal; Dose Fractionation, Radiation; Dose-Response Relationship, Radiation; Female; Humans; Male; Mice; Mice, SCID; Neoplasm Transplantation; Niacinamide; Oxygen; Oxygen Consumption; Pharyngeal Neoplasms; Radiation Dosage; Radiation-Sensitizing Agents; Sensitivity and Specificity; Tirapazamine; Triazines; Tumor Cells, Cultured | 1999 |
Clinical outcome and tumour microenvironmental effects of accelerated radiotherapy with carbogen and nicotinamide.
Topics: Carbon Dioxide; Cell Division; Cell Hypoxia; Head and Neck Neoplasms; Humans; Niacinamide; Oxygen; Radiation-Sensitizing Agents | 1999 |
Enhancement of tumor perfusion and oxygenation by carbogen and nicotinamide during single- and multifraction irradiation.
Topics: Animals; Carbocyanines; Carbon Dioxide; Cell Hypoxia; Combined Modality Therapy; Dose Fractionation, Radiation; Etanidazole; Female; Fibrosarcoma; Fluorescent Dyes; Hydrocarbons, Fluorinated; Indicators and Reagents; Mice; Mice, Inbred C3H; Niacinamide; Oxygen; Oxygen Consumption; Radiation-Sensitizing Agents; Tumor Cells, Cultured | 2000 |
Hypoxic radiosensitizers in radical radiotherapy for patients with bladder carcinoma: hyperbaric oxygen, misonidazole, and accelerated radiotherapy, carbogen and nicotinamide.
Topics: Carbon Dioxide; Humans; Hyperbaric Oxygenation; Misonidazole; Niacinamide; Oxygen; Radiation-Sensitizing Agents; Urinary Bladder Neoplasms | 2000 |
Effects of nicotinamide and carbogen on tumour oxygenation, blood flow, energetics and blood glucose levels.
Topics: Animals; Blood Glucose; Carbon Dioxide; Energy Metabolism; Female; Hydralazine; Magnetic Resonance Imaging; Niacinamide; Oxygen; Prolactinoma; Rats; Rats, Inbred WF; Time Factors | 2000 |
Effects of nicotinamide and carbogen on oxygenation in human tumor xenografts measured with luminescense based fiber-optic probes.
Topics: Analysis of Variance; Animals; Carbon Dioxide; Cell Hypoxia; Disease Models, Animal; Fiber Optic Technology; Humans; Linear Models; Luminescent Measurements; Niacinamide; Nitroimidazoles; Optical Fibers; Oxygen; Radiation-Sensitizing Agents; Sensitivity and Specificity; Transplantation, Heterologous; Tumor Cells, Cultured | 2000 |
Fractionated irradiation combined with carbogen breathing and nicotinamide of two human glioblastomas grafted in nude mice.
Topics: Administration, Inhalation; Animals; Brain Neoplasms; Carbon Dioxide; Cell Division; Combined Modality Therapy; Dose Fractionation, Radiation; Drug Therapy, Combination; Female; Glioblastoma; Humans; Mice; Mice, Nude; Niacinamide; Oxygen; Radiation Injuries, Experimental; Radiation-Sensitizing Agents; Skin; Tumor Cells, Cultured; Xenograft Model Antitumor Assays | 2001 |
Effects of the interaction between carbogen and nicotinamide on R3230 Ac tumor blood flow in Fischer 344 rats.
Topics: Animals; Arterioles; Blood Pressure; Carbon Dioxide; Female; Heart Rate; Mammary Neoplasms, Experimental; Niacinamide; Oxygen; Radiation-Sensitizing Agents; Rats; Rats, Inbred F344; Regional Blood Flow | 2001 |
Photodynamic therapy for malignant mesothelioma: preclinical studies for optimization of treatment protocols.
Topics: Animals; Carbon Dioxide; Combined Modality Therapy; Disease Models, Animal; Dose-Response Relationship, Drug; Dose-Response Relationship, Radiation; Female; Humans; Mesoporphyrins; Mesothelioma; Mice; Mice, Inbred BALB C; Mice, Nude; Neoplasm Transplantation; Niacinamide; Oxygen; Photochemotherapy; Photosensitizing Agents | 2001 |
The modification of human tumour blood flow using pentoxifylline, nicotinamide and carbogen.
Topics: Administration, Inhalation; Administration, Oral; Adult; Aged; Carbon Dioxide; Female; Humans; Laser-Doppler Flowmetry; Male; Microcirculation; Middle Aged; Neoplasms; Niacinamide; Oxygen; Pentoxifylline; Radiation-Sensitizing Agents; Regional Blood Flow; Time Factors; Up-Regulation | 2002 |
Pharmacology and toxicity of nicotinamide combined with domperidone during fractionated radiotherapy.
Topics: Adult; Aged; Aged, 80 and over; Carbon Dioxide; Carcinoma; Domperidone; Dose Fractionation, Radiation; Female; Humans; Male; Middle Aged; Nausea; Niacinamide; Oropharyngeal Neoplasms; Oxygen; Radiation-Sensitizing Agents; Vomiting | 2002 |
The effect of nicotinamide & hyperoxic gases on blood glucose.
Topics: Animals; Blood Glucose; Blood Pressure; Carbon Dioxide; Female; Hyperoxia; Niacinamide; Oxygen; Rats; Rats, Inbred F344 | 2003 |
Preclinical studies on how to deal with patient intolerance to nicotinamide and carbogen.
Topics: Animals; Carbon Dioxide; Dose Fractionation, Radiation; Dose-Response Relationship, Radiation; Female; Mammary Neoplasms, Experimental; Mice; Mice, Inbred Strains; Neoplasm Transplantation; Niacinamide; Oxygen; Partial Pressure; Radiation-Sensitizing Agents; Radiotherapy Dosage | 2004 |
Radiotoxicity on bone marrow after 89Sr therapy radiosensitized by nicotinamide and carbogen in mice.
Topics: Administration, Inhalation; Animals; Bone Marrow; Carbon Dioxide; Chromosomes; Female; Injections, Intraperitoneal; Injections, Intravenous; Male; Mice; Mice, Inbred BALB C; Micronucleus Tests; Niacinamide; Oxygen; Radiation Injuries; Radiation Tolerance; Radiation-Sensitizing Agents; Radiopharmaceuticals; Strontium Radioisotopes | 2004 |
Effects of nicotinamide and carbogen in different murine colon carcinomas: immunohistochemical analysis of vascular architecture and microenvironmental parameters.
Topics: Animals; Benzimidazoles; Bromodeoxyuridine; Carbon Dioxide; Cell Hypoxia; Cell Line, Tumor; Colonic Neoplasms; Female; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Niacinamide; Nitroimidazoles; Oxygen; Radiation-Sensitizing Agents | 2004 |
Is sensitization with nicotinamide and carbogen dependent on nicotinamide concentration at the time of irradiation?
Topics: Animals; Carbon Dioxide; Dose-Response Relationship, Drug; Female; Mammary Neoplasms, Experimental; Mice; Mice, Inbred CBA; Niacinamide; Oxygen; Radiation-Sensitizing Agents; Skin | 2004 |
Physiological noise in murine solid tumours using T2*-weighted gradient-echo imaging: a marker of tumour acute hypoxia?
Topics: Animals; Biomarkers, Tumor; Carbon Dioxide; Cell Hypoxia; Cell Line, Tumor; Computer Simulation; Fibrosarcoma; Flunarizine; Image Interpretation, Computer-Assisted; Magnetic Resonance Imaging; Male; Mice; Mice, Inbred C3H; Models, Biological; Niacinamide; Oxygen; Reproducibility of Results; Sensitivity and Specificity; Signal Processing, Computer-Assisted; Stochastic Processes | 2004 |
In vivo determination of tumor oxygenation during growth and in response to carbogen breathing using 15C5-loaded alginate capsules as fluorine-19 magnetic resonance imaging oxygen sensors.
Topics: Alginates; Animals; Carbon Dioxide; Cell Hypoxia; Crown Ethers; Fluorine; Glucuronic Acid; Hexuronic Acids; Hydralazine; Magnetic Resonance Imaging; Neoplasms; Niacinamide; Oxygen; Partial Pressure; Radiation-Sensitizing Agents; Rats; Rats, Inbred WF; Vasodilator Agents | 2004 |
Hyperthermic enhancement of tumor radiosensitization strategies.
Topics: Administration, Inhalation; Animals; Carbon Dioxide; Cell Death; Cell Line; Cell Line, Tumor; Cell Survival; Cells, Cultured; Endothelium, Vascular; Female; Hyperthermia, Induced; Male; Mice; Mice, Inbred C3H; Niacinamide; Oxygen; Radiation-Sensitizing Agents; Rats; Rats, Inbred F344 | 2005 |
Modulation of hypoxia in murine liver metastases of colon carcinoma by nicotinamide and carbogen.
Topics: Animals; Carbon Dioxide; Carcinoma; Cell Hypoxia; Cell Line, Tumor; Cell Proliferation; Colonic Neoplasms; Drug Combinations; Female; Liver Neoplasms; Mice; Mice, Inbred BALB C; Niacinamide; Oxygen | 2005 |
The prognostic value of endogenous hypoxia-related markers for head and neck squamous cell carcinomas treated with ARCON.
Topics: Adult; Aged; Aged, 80 and over; Antigens, Neoplasm; Biomarkers, Tumor; Carbon Dioxide; Carbonic Anhydrase IX; Carbonic Anhydrases; Carcinoma, Squamous Cell; Clinical Trials, Phase II as Topic; Combined Modality Therapy; Disease-Free Survival; Female; Glucose Transporter Type 1; Glucose Transporter Type 3; Head and Neck Neoplasms; Humans; Hypoxia; Immunohistochemistry; Male; Middle Aged; Niacinamide; Oxygen; Predictive Value of Tests; Prognosis; Radiation Dosage; Treatment Outcome | 2006 |
Hypoxia inducible factor-1 alpha and vascular endothelial growth factor expression are associated with a poor prognosis in patients with nasopharyngeal carcinoma receiving radiotherapy with carbogen and nicotinamide.
Topics: Adult; Aged; Biomarkers; Carbon Dioxide; Female; Gene Expression; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Male; Middle Aged; Nasopharyngeal Neoplasms; Niacinamide; Oxygen; Prognosis; Radiation-Sensitizing Agents; Survival Analysis; Vascular Endothelial Growth Factor A | 2008 |
Blood flow and Vd (water): both biomarkers required for interpreting the effects of vascular targeting agents on tumor and normal tissue.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Biomarkers, Tumor; Carbon Dioxide; Female; Humans; Male; Middle Aged; Neoplasms; Niacinamide; Organ Specificity; Oxygen; Regional Blood Flow; Water | 2009 |
Elusive goal of targeting tumor hypoxia for therapeutic gain.
Topics: Carbon Dioxide; Carcinoma, Squamous Cell; Female; Humans; Laryngeal Neoplasms; Male; Niacinamide; Oxygen; Radiation-Sensitizing Agents; Vitamin B Complex | 2012 |
Computed tomography-based tumour volume as a predictor of outcome in laryngeal cancer: results of the phase 3 ARCON trial.
Topics: Carbon Dioxide; Clinical Trials, Phase III as Topic; Combined Modality Therapy; Disease-Free Survival; Female; Follow-Up Studies; Humans; Laryngeal Neoplasms; Male; Middle Aged; Neoplasm Staging; Niacinamide; Outcome Assessment, Health Care; Oxygen; Prognosis; Radiation-Sensitizing Agents; Randomized Controlled Trials as Topic; Tomography, X-Ray Computed; Tumor Burden | 2014 |
The effect of carbogen breathing and nicotinamide added to standard (chemo)radiation treatment of advanced cervical cancer in Indonesia.
Topics: Administration, Oral; Adult; Aged; Antineoplastic Agents; Carbon Dioxide; Chemoradiotherapy; Cisplatin; Female; Follow-Up Studies; Humans; Indonesia; Middle Aged; Neoplasm Staging; Niacinamide; Oxygen; Prognosis; Prospective Studies; Radiation-Sensitizing Agents; Respiratory Therapy; Survival Rate; Uterine Cervical Neoplasms; Vitamin B Complex | 2014 |
Targeting tumour hypoxia to improve outcome of stereotactic radiotherapy.
Topics: Administration, Inhalation; Animals; Carbon Dioxide; Cell Hypoxia; Diphosphates; Female; Hyperthermia, Induced; Mammary Neoplasms, Experimental; Mice, Inbred C3H; Niacinamide; Nimorazole; Oxygen; Radiation-Sensitizing Agents; Radiosurgery; Radiotherapy Dosage; Stilbenes; Vitamin B Complex | 2015 |
A Gene Signature for Selecting Benefit from Hypoxia Modification of Radiotherapy for High-Risk Bladder Cancer Patients.
Topics: Aged; Carbon Dioxide; Clinical Trials, Phase III as Topic; Female; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Humans; Hypoxia; Kaplan-Meier Estimate; Male; Middle Aged; Niacinamide; Oxygen; Prognosis; Randomized Controlled Trials as Topic; Risk Factors; Urinary Bladder Neoplasms | 2017 |
Concurrent carbogen and nicotinamide with radiation therapy in muscle invasive bladder cancer: A report on feasibility in the Australian setting.
Topics: Aged; Australia; Carbon Dioxide; Feasibility Studies; Humans; Muscles; Neoplasm Recurrence, Local; Niacinamide; Oxygen; Urinary Bladder Neoplasms | 2021 |