carbodiimides has been researched along with methotrexate in 4 studies
| Studies (carbodiimides) | Trials (carbodiimides) | Recent Studies (post-2010) (carbodiimides) | Studies (methotrexate) | Trials (methotrexate) | Recent Studies (post-2010) (methotrexate) |
|---|---|---|---|---|---|
| 1,534 | 1 | 361 | 41,593 | 5,666 | 11,969 |
| Protein | Taxonomy | carbodiimides (IC50) | methotrexate (IC50) |
|---|---|---|---|
| Thymidylate synthase | Escherichia coli | 1.8 | |
| nuclear receptor coactivator 3 isoform a | Homo sapiens (human) | 0.211 | |
| Toll-like receptor 4 | Homo sapiens (human) | 1.04 | |
| Fatty-acid amide hydrolase 1 | Mus musculus (house mouse) | 0.08 | |
| Dihydrofolate reductase | Homo sapiens (human) | 0.0522 | |
| Dihydrofolate reductase | Mus musculus (house mouse) | 0.0331 | |
| Dihydrofolate reductase | Bos taurus (cattle) | 0.0348 | |
| Dihydrofolate reductase | Gallus gallus (chicken) | 0.0545 | |
| Dihydrofolate reductase | Enterococcus faecium | 0.0014 | |
| Dihydrofolate reductase | Lacticaseibacillus casei | 0.0138 | |
| Thymidylate synthase | Homo sapiens (human) | 0.343 | |
| 5-hydroxytryptamine receptor 2C | Rattus norvegicus (Norway rat) | 0.0147 | |
| Thymidylate synthase | Escherichia coli K-12 | 0.0181 | |
| Dihydrofolate reductase | Escherichia coli K-12 | 0.1529 | |
| Bifunctional dihydrofolate reductase-thymidylate synthase | Plasmodium falciparum K1 | 0.084 | |
| Folate receptor beta | Homo sapiens (human) | 0.1585 | |
| 5-hydroxytryptamine receptor 2A | Rattus norvegicus (Norway rat) | 0.0011 | |
| Cytochrome P450 11B1, mitochondrial | Bos taurus (cattle) | 0.0012 | |
| Folate receptor alpha | Homo sapiens (human) | 0.2263 | |
| Dihydrofolate reductase | Pneumocystis carinii | 0.0717 | |
| Histidine decarboxylase | Rattus norvegicus (Norway rat) | 0.0014 | |
| Trifunctional purine biosynthetic protein adenosine-3 | Homo sapiens (human) | 0.01 | |
| Bifunctional purine biosynthesis protein ATIC | Homo sapiens (human) | 0.01 | |
| Delta-type opioid receptor | Rattus norvegicus (Norway rat) | 0.003 | |
| Mu-type opioid receptor | Rattus norvegicus (Norway rat) | 0.003 | |
| Kappa-type opioid receptor | Rattus norvegicus (Norway rat) | 0.003 | |
| Reduced folate transporter | Homo sapiens (human) | 0.012 | |
| Dihydrofolate reductase | Mycobacterium tuberculosis H37Rv | 0.0174 | |
| Folylpolyglutamate synthase, mitochondrial | Homo sapiens (human) | 3.2 | |
| Bifunctional dihydrofolate reductase-thymidylate synthase | Toxoplasma gondii | 0.0547 | |
| Bifunctional dihydrofolate reductase-thymidylate synthase | Trypanosoma cruzi | 0.11 | |
| Dihydrofolate reductase | Bacillus anthracis | 0.0136 | |
| Dihydrofolate reductase | Rattus norvegicus (Norway rat) | 0.0047 | |
| Proton-coupled folate transporter | Homo sapiens (human) | 0.1207 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (50.00) | 18.7374 |
| 1990's | 1 (25.00) | 18.2507 |
| 2000's | 1 (25.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Ryser, HJ; Shen, WC | 1 |
| Aull, JL; Chen, DH; Daron, HH | 1 |
| Bohuon, C; Boudene, C; Duprey, F | 1 |
| Chen, CS; Ofner, CM | 1 |
4 other study(ies) available for carbodiimides and methotrexate
| Article | Year |
|---|---|
Conjugation of methotrexate to poly(L-lysine) increases drug transport and overcomes drug resistance in cultured cells.
Topics: Biological Transport; Carbodiimides; Cell Division; Cells, Cultured; Drug Resistance; Methotrexate; Peptides; Polylysine; Trypsin | 1978 |
1-Phenyl-3-trimethylaminopropyl carbodiimide: a new inhibitor of thymidylate synthase.
Topics: Carbodiimides; Carbon Radioisotopes; Dithionitrobenzoic Acid; Drug Resistance, Microbial; Ethyldimethylaminopropyl Carbodiimide; Kinetics; Lacticaseibacillus casei; Methotrexate; Scintillation Counting; Thymidylate Synthase | 1992 |
Radioimmunoassay of methotrexate in biological fluids.
Topics: Animals; Carbodiimides; Folic Acid; Humans; Methotrexate; Rabbits; Radioimmunoassay; Serum Albumin, Bovine; Tetrahydrofolates; Time Factors; Tritium | 1974 |
The effect of molecular weight, drug load, and charge of gelatin-MTX conjugates on growth inhibition of HL-60 leukemia cells.
Topics: Antimetabolites, Antineoplastic; Carbodiimides; Cell Proliferation; Chemistry, Pharmaceutical; Dose-Response Relationship, Drug; Drug Carriers; Drug Compounding; Ethylenediamines; Gelatin; HL-60 Cells; Humans; Inhibitory Concentration 50; Isoelectric Focusing; Leukemia; Methotrexate; Molecular Weight; Nephelometry and Turbidimetry; Spectrophotometry, Ultraviolet; Surface Properties | 2009 |