carbocyclic-inosine has been researched along with aristeromycin* in 1 studies
1 other study(ies) available for carbocyclic-inosine and aristeromycin
| Article | Year |
|---|---|
Carbocyclic inosine as a potent anti-leishmanial agent: the metabolism and selective cytotoxic effects of carbocyclic inosine in promastigotes of Leishmania tropica and Leishmania donovani.
Carbocyclic inosine is a potent inhibitor for the growth of the promastigote form of Leishmania tropica and Leishmania donovani. In culture, the EC50 values of carbocyclic inosine are 8.3 X 10(-8) and 1.3 X 10(-7) M for the promastigotes of L. tropica and L. donovani, respectively. On the other hand, it is less toxic towards mouse mammary tumor FM3A cells: the EC50 value is 2.7 X 10(-4) M. Carbocyclic inosine is metabolized by Leishmania promastigotes to give carbocyclic adenosine-5'-triphosphate (aristeromycin-5'-triphosphate) and carbocyclic guanosine-5'-triphosphate. This metabolic conversion provides a mechanism for the parasite-selective toxicity of carbocyclic inosine. Topics: Adenosine; Animals; Chemical Phenomena; Chemistry; Chromatography, High Pressure Liquid; Inosine; Leishmania donovani; Leishmania tropica; Mice; Trypanocidal Agents | 1986 |