carbidopa and entacapone

carbidopa has been researched along with entacapone in 107 studies

Research

Studies (107)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	15 (14.02)	18.2507
2000's	33 (30.84)	29.6817
2010's	48 (44.86)	24.3611
2020's	11 (10.28)	2.80

Authors

Authors	Studies
Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ	1
Ekins, S; Williams, AJ; Xu, JJ	1
Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ	1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K	1
Männistö, PT; Tuomainen, P; Tuominen, RK	1
Männistö, PT; Törnwall, M	2
Kaakkola, S; Kask, A; Männistö, PT; Törnwall, M; Tuomainen, P	1
Lang, A; Männistö, PT; Rauhala, P; Vasar, E	1
Deleu, D; Ebinger, G; Michotte, Y; Sarre, S	1
Brooks, DJ; Burn, DJ; Lammertsma, AA; Luthra, S; Morrish, PK; Osman, S; Sawle, GV; Snow, BJ	1
Dethy, S; Goldman, S; Luxen, A; Monclus, M; Pauwels, T	1
Illi, A; Keränen, T; Myllylä, VV; Sotaniemi, KA; Suominen, K	1
Kaakkola, S; Wurtman, RJ	1
Gordin, A; Harjola, VP; Karlsson, M; Keränen, T; Korpela, K; Pentikäinen, PJ; Rita, H; Seppälä, L; Wikberg, T	1
Ahtila, S; Gordin, A; Heinävaara, S; Kaakkola, S; Karlsson, M; Korpela, K; Männistö, PT; Tuomainen, P; Wikberg, T	1
Gordin, A; Jenner, P; Marsden, CD; Smith, LA	1
Gordin, A; Huhtala, S; Huupponen, R; Korpela, K; Reinikainen, K; Rouru, J; Savontaus, E; Scheinin, M	1
Ahlskog, JE	2
Brooks, DJ; Gordin, A; Karlsson, M; Korpela, K; Pavese, N; Piccini, P	1
Gerlach, M; Kuhn, W; Lehnfeld, R; Riederer, P; Sontag, KH; Waldmeier, P; Xiao, AY	1
Halliwell, B; Jenner, P; Lyras, L; McKenzie, G; Pearce, RK; Zeng, BY	1
Sharif, AA	1
Hansard, MJ; Jackson, MJ; Jenner, P; Maratos, E; Smith, LA	1
Hauser, RA	2
Barbato, L; Bolner, A; Caraceni, T; Nordera, G; Stocchi, F	1
Bassi, A; Brusa, L; Fedele, E; Giacomini, P; Lunardi, G; Pierantozzi, M; Stanzione, P	1
Bassi, A; Brusa, L; Fedele, E; Lunardi, G; Pasqualetti, P; Peppe, A; Pierantozzi, M; Stanzione, P; Stefani, A	1
Al-Barghouthy, G; Jackson, MJ; Jenner, P; Kuoppamaki, M; Olanow, W; Rose, S; Smith, LA	1
Bronstein, J; Guarnieri, M; Hubble, J; Kang, GA; Ostrem, JL; Rabinowicz, AL; Subramanian, I	1
Silver, DE	1
Alvarez, L; Castro, A; Gimenez-Roldan, S; Grandas, F; Hernandez, B; Jenner, P; Linazasoro, G; Luquin, MR; Macias, R; Marin, C; Obeso, JA; Pavon, N; Rodriguez, M; Rodriguez-Oroz, MC; Stochi, F; Tolosa, E; Vaamonde, J; Valldeoriola, F	1
Agid, Y; Brooks, DJ; Eggert, K; Holopainen, A; Ostergaard, K; Widner, H	1
Bremen, D; Erdmann, C; Muhlack, S; Müller, T; Przuntek, H; Woitalla, D	1
Brown, LA; Doan, J; Pellis, SM; Suchowersky, O; Whishaw, IQ	1
Bremen, D; Erdmann, C; Goetze, O; Muhlack, S; Müller, T; Przuntek, H; Woitalla, D	1
Stocchi, F	1
Haapaniemi, T; Hartikainen, P; Heikkinen, H; Jolma, T; Kaakkola, S; Kinnunen, E; Kuopio, AM; Myllylä, V; Nuutinen, J; Rissanen, A; Satomaa, O	1
Ander, L; Kolf, K; Muhlack, S; Müller, T; Woitalla, D	1
Hauser, RA; Schapira, AH; Simonson, W	1
Erdmann, C; Goetze, O; Müller, T; Woitalla, D	1
Aste, R; Cannas, A; Congia, S; Floris, G; Marrosu, MG; Solla, P; Tacconi, P	1
Fung, VS; Herawati, L; Wan, Y	1
Abbruzzese, G; Dronamraju, N; Hauser, RA; Kakarieka, A; Mancione, L; Panisset, M	1
Arai, H; Hatta, K; Hattori, N; Ishikawa, K; Kamigaichi, R; Kubo, S; Mochizuki, H; Ogaki, K; Usui, C; Yokoyama, K	1
Ellmén, J; Hänninen, J; Hartikainen, P; Kaakkola, S; Kaasinen, V; Kailajärvi, M; Korpela, K; Kuoppamäki, M; Löyttyniemi, E; Lyytinen, J; Marttila, R; Ruokoniemi, P	1
Guarnieri, M; Hubble, JP; Jennings, D; LeWitt, PA; Lyons, KE; Murck, H; Pahwa, R; Rabinowicz, AL; Wang, J	1
Hauser, RA; Seeberger, LC	1
Muhlack, S; Müller, T	2
Amar, K; Eggert, K; Kuoppamäki, M; Leinonen, M; Luotonen, L; Nissinen, H; Oertel, W; Skogar, O	1
Goldstein, DS; Holmes, C; Kopin, IJ; Pechnik, S; Sewell, L	1
Delea, TE; Hagiwara, M; Mancione, L; Thomas, SK	1
Müller, T	1
Barone, P; Jankovic, J; Kieburtz, K; Lang, AE; Olanow, CW; Poewe, W; Rascol, O; Stocchi, F; Tolosa, E	1
Almeida, L; Ferreira, JJ; Nunes, T; Poewe, W; Rascol, O; Rocha, JF; Sampaio, C; Soares-da-Silva, P	1
Armand, C; Groenendaal, H; Tarrants, ML	1
Ellmén, J; Kailajärvi, M; Korpela, K; Kuoppamäki, M; Lehtinen, T; Sauramo, A; Vahteristo, M	1
Barba, E; Bugamelli, F; Marcheselli, C; Raggi, MA	1
Ferreira, JJ; Sampaio, C	1
Delea, TE; Hagiwara, M; Thomas, SK	1
Muhlack, S; Müller, T; Woitalla, D	1
Lew, MF; McCague, K; Somogyi, M; Welsh, M	1
Ellmén, J; Ingman, K; Korpela, I; Kuoppamäki, M; Naukkarinen, T; Vahteristo, M	1
Ishihara, A; Kihira, K; Kimura, Y; Matsumoto, M; Miyachi, T; Nakamura, T; Ohtsuki, T; Yamawaki, T	1
Emre, M; Reichmann, H	1
Bini, V; Bortolato, M; Cannas, A; Marrosu, F; Puligheddu, M; Solla, P	1
Tarsy, D	1
Belavic, J	1
Derkinderen, P; Lebouvier, T; Pouclet, H	1
Aquilonius, SM; Bäckström, T; Ehrnebo, M; Lewander, T; Nyholm, D; Nyström, C; Panagiotidis, G; Spira, J; Trolin, CG	1
Jančić Stojanović, B; Malenović, A; Stamenković, I; Vemić, A	1
Arai, M	1
de Jong, MH; Van Gool, AR; Zemel, D	1
Hernández, B; Martínez-Martín, P; Ricart, J	1
Hernández, B; Kulisevsky, J; Linazasoro, G; López-Lozano, JJ; Marey, J; Mir, P; Tolosa, E	1
Herrmann, L; Muhlack, S; Müller, T; Salmen, S	1
Dillmann, U; Ellenbogen, A; Gupta, S; Hsu, A; Kell, S; Khanna, S; Liang, G; Mahler, A; Rubens, R; Stocchi, F	1
Cardoso, MA; de Carvalho, KA; de Francisco, TM; de Oliveira Vilhena, R; Gasparetto, JC; Guimarães de Francisco, TM; Martins, CA; Pontarolo, R; Ribeiro, RP	1
Kuoppamäki, M; Leinonen, M; Poewe, W	1
Elmer, L; Gil, RA; Gupta, S; Hsu, A; Kell, S; Khanna, S; Modi, NB; Nausieda, PA; Rubens, R; Singer, C; Spiegel, J	1
Bedi, G; Bisaga, A; Foltin, RW; Nunes, EV; Shiffrin, L; Vadhan, NP	1
Baek, JS; Choo, CC; Loo, SC; Qian, C; Shen, Z; Tan, NS	1
Abdel-Ghany, MF; Ayad, MF; Hussein, LA; Youssef, MM	1
Fox, SH; Freitas, ME; Ruiz-Lopez, M	1
Nielsen, EI; Nyholm, D; Senek, M	2
Altamura, C; Basile, S; Calcagno, M; Garibaldi, S; Pinelli, S; Salerno, MG	1
Klein, S; Wollmer, E	1
Baek, JS; Ho, HK; Lim, KL; Loo, SCJ; Pang, YY; Tan, EY; Tee, JK	1
Alaa, H; Belal, F; Ibrahim, F; Sheribah, ZA	1
Metzer, WS; Rodrigues, FB	1
Di Vico, IA; Novelli, A; Ramat, S; Sorbi, S; Terenzi, F	1
Li, K; Li, S; Liao, X; Liu, D; Shuai, B; Wu, N	1
Burmaoğlu, RE; Sağlık Aslan, S	1
Adar, L; Caraco, Y; Case, R; Djaldetti, R; Giladi, N; Gurevich, T; Leibman-Barak, S; Sasson, N	1
Habet, S	1
Müller, T; Schlegel, E; Thiede, HM; Zingler, S	1
Ellmén, J; Kuoppamäki, M; Rouru, J; Sjöstedt, N; Tuunainen, J; Vahteristo, M; Yliperttula, M	1
Langer, K; Rose, O; Weitzel, J; Wünsch, A	1
Baló, B; Botz, K; Györfi, B; Jost, WH	1
Jost, WH	1
Antonini, A; D'Onofrio, V; Guerra, A	1

Reviews

15 review(s) available for carbidopa and entacapone

Article	Year
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans. Drug discovery today, 2016, Volume: 21, Issue:4 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk	2016
Medical treatment of later-stage motor problems of Parkinson disease. Mayo Clinic proceedings, 1999, Volume: 74, Issue:12 Topics: Amantadine; Antiparkinson Agents; Benzophenones; Carbidopa; Catechol O-Methyltransferase Inhibitors; Catechols; Cholinergic Antagonists; Dopamine Agonists; Dose-Response Relationship, Drug; Drug Combinations; Dyskinesia, Drug-Induced; Enzyme Inhibitors; Humans; Levodopa; Nitriles; Nitrophenols; Parkinson Disease, Secondary; Propranolol; Randomized Controlled Trials as Topic; Selegiline; Tolcapone	1999
Entacapone/levodopa/carbidopa combination tablet: Stalevo. Drugs in R&D, 2003, Volume: 4, Issue:5 Topics: Administration, Oral; Antiparkinson Agents; Carbidopa; Catechols; Clinical Trials as Topic; Drug Combinations; Humans; Levodopa; Movement Disorders; Nitriles; Parkinson Disease; Tablets	2003
Clinical experience with the novel levodopa formulation entacapone + levodopa + carbidopa (Stalevo). Expert review of neurotherapeutics, 2004, Volume: 4, Issue:4 Topics: Antiparkinson Agents; Carbidopa; Catechols; Drug Combinations; Drug Therapy, Combination; Humans; Levodopa; Nitriles; Parkinson Disease	2004
[Optimization of use of levodopa in Parkinson's disease: role of levodopa-carbidopa-entacapone combination]. Neurologia (Barcelona, Spain), 2005, Volume: 20, Issue:4 Topics: Akathisia, Drug-Induced; Animals; Antiparkinson Agents; Carbidopa; Catechols; Clinical Trials as Topic; Dopamine; Drug Therapy, Combination; Humans; Hyperhomocysteinemia; Levodopa; MPTP Poisoning; Neuroprotective Agents; Nitriles; Parkinson Disease; Parkinsonian Disorders; Rats; Treatment Outcome	2005
The levodopa wearing-off phenomenon in Parkinson's disease: pharmacokinetic considerations. Expert opinion on pharmacotherapy, 2006, Volume: 7, Issue:10 Topics: Animals; Antiparkinson Agents; Aromatic Amino Acid Decarboxylase Inhibitors; Carbidopa; Catechol O-Methyltransferase; Catechol O-Methyltransferase Inhibitors; Catechols; Clinical Trials as Topic; Delayed-Action Preparations; Dopa Decarboxylase; Drug Administration Schedule; Drug Therapy, Combination; Drug Tolerance; Dyskinesia, Drug-Induced; Enzyme Inhibitors; Humans; Levodopa; Nitriles; Parkinson Disease	2006
Long-term care of Parkinson's disease. Strategies for managing "wearing off" symptom re-emergence and dyskinesias. Geriatrics, 2006, Volume: 61, Issue:9 Topics: Antiparkinson Agents; Carbidopa; Catechol O-Methyltransferase Inhibitors; Catechols; Drug Therapy, Combination; Dyskinesia, Drug-Induced; Humans; Levodopa; Long-Term Care; Nitriles; Parkinson Disease	2006
Role of the pharmacist in the effective management of wearing-off in Parkinson's disease. The Annals of pharmacotherapy, 2007, Volume: 41, Issue:11 Topics: Antiparkinson Agents; Carbidopa; Catechols; Dopamine Agonists; Drug Combinations; Drug Therapy, Combination; Dyskinesia, Drug-Induced; Humans; Levodopa; Monoamine Oxidase Inhibitors; Nitriles; Parkinson Disease; Patient Education as Topic; Pharmacists; Professional Role; Severity of Illness Index	2007
Entacapone. Expert opinion on drug metabolism & toxicology, 2010, Volume: 6, Issue:8 Topics: Animals; Antiparkinson Agents; Biological Availability; Carbidopa; Catechol O-Methyltransferase Inhibitors; Catechols; Drug Therapy, Combination; Dyskinesia, Drug-Induced; Enzyme Inhibitors; Half-Life; Humans; Levodopa; Nitriles; Parkinson Disease	2010
Optimizing levodopa therapy to treat wearing-off symptoms in Parkinson's disease: focus on levodopa/carbidopa/entacapone. Expert review of neurotherapeutics, 2012, Volume: 12, Issue:2 Topics: Antiparkinson Agents; Carbidopa; Catechols; Drug Administration Schedule; Drug Therapy, Combination; Humans; Levodopa; Nitriles; Parkinson Disease	2012
Parkinson disease treatment in hospitals and nursing facilities: avoiding pitfalls. Mayo Clinic proceedings, 2014, Volume: 89, Issue:7 Topics: Amantadine; Antiparkinson Agents; Carbidopa; Catechols; Dopamine Agonists; Drug Administration Schedule; Drug Combinations; Hospitalization; Humans; Levodopa; Monoamine Oxidase Inhibitors; Nitriles; Nursing Care; Parkinson Disease	2014
Novel Levodopa Formulations for Parkinson's Disease. CNS drugs, 2016, Volume: 30, Issue:11 Topics: Antiparkinson Agents; Carbidopa; Catechols; Chemistry, Pharmaceutical; Drug Combinations; Humans; Levodopa; Nitriles; Parkinson Disease	2016
Levodopa/carbidopa/entacapone for the treatment of early Parkinson's disease: a meta-analysis. Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 2020, Volume: 41, Issue:8 Topics: Antiparkinson Agents; Carbidopa; Catechols; Drug Combinations; Humans; Levodopa; Nitriles; Parkinson Disease	2020
[Triple combination of levodopa, carbidopa and entacapone by intrajejunal pump in advanced Parkinson's disease]. Ideggyogyaszati szemle, 2022, Nov-30, Volume: 75, Issue:11-12 Topics: Antiparkinson Agents; Carbidopa; Drug Combinations; Gels; Humans; Levodopa; Observational Studies as Topic; Parkinson Disease	2022
Current and novel infusion therapies for patients with Parkinson's disease. Journal of neural transmission (Vienna, Austria : 1996), 2023, Volume: 130, Issue:11 Topics: Antiparkinson Agents; Carbidopa; Catechol O-Methyltransferase; Catechols; Dopamine Agonists; Drug Combinations; Humans; Levodopa; Parkinson Disease	2023

Trials

38 trial(s) available for carbidopa and entacapone

Article	Year
The effect of entacapone (OR-611) on brain [18F]-6-L-fluorodopa metabolism: implications for levodopa therapy of Parkinson's disease. Neurology, 1994, Volume: 44, Issue:7 Topics: Aged; Brain; Carbidopa; Catechol O-Methyltransferase Inhibitors; Catechols; Corpus Striatum; Dihydroxyphenylalanine; Drug Synergism; Female; Fluorine Radioisotopes; Humans; Levodopa; Male; Middle Aged; Nitriles; Occipital Lobe; Parkinson Disease; Tomography, Emission-Computed	1994
Effect of entacapone, a COMT inhibitor, on the pharmacokinetics of levodopa and on cardiovascular responses in patients with Parkinson's disease. European journal of clinical pharmacology, 1993, Volume: 45, Issue:5 Topics: Aged; Blood Pressure; Carbidopa; Catechol O-Methyltransferase Inhibitors; Catechols; Hemodynamics; Homovanillic Acid; Humans; Levodopa; Middle Aged; Nitriles; Parkinson Disease; Pulse; Respiration	1993
Effect of entacapone, a COMT inhibitor, on the pharmacokinetics and metabolism of levodopa after administration of controlled-release levodopa-carbidopa in volunteers. Clinical neuropharmacology, 1995, Volume: 18, Issue:1 Topics: Adult; Carbidopa; Catechols; Dopamine Agonists; Dose-Response Relationship, Drug; Drug Combinations; Enzyme Inhibitors; Humans; Levodopa; Male; Nitriles; Reference Values	1995
Pharmacokinetics of oral entacapone after frequent multiple dosing and effects on levodopa disposition. European journal of clinical pharmacology, 1999, Volume: 55, Issue:6 Topics: Adult; Antiparkinson Agents; Carbidopa; Catechol O-Methyltransferase; Catechol O-Methyltransferase Inhibitors; Catechols; Drug Interactions; Enzyme Inhibitors; Erythrocytes; Humans; Levodopa; Male; Nitriles	1999
The catechol-O-methyltransferase (COMT) inhibitor entacapone enhances the pharmacokinetic and clinical response to Sinemet CR in Parkinson's disease. Journal of neurology, neurosurgery, and psychiatry, 2000, Volume: 68, Issue:5 Topics: Adult; Aged; Antiparkinson Agents; Biological Availability; Carbidopa; Catechol O-Methyltransferase Inhibitors; Catechols; Cross-Over Studies; Delayed-Action Preparations; Double-Blind Method; Drug Combinations; Enzyme Inhibitors; Female; Humans; Levodopa; Male; Middle Aged; Nitriles; Parkinson Disease	2000
Levodopa/carbidopa/entacapone (Stalevo). Neurology, 2004, Jan-13, Volume: 62, Issue:1 Suppl 1 Topics: Aged; Antiparkinson Agents; Area Under Curve; Biological Availability; Carbidopa; Catechols; Clinical Trials, Phase III as Topic; Drug Combinations; Drug Evaluation; Female; Headache; Humans; Levodopa; Male; Middle Aged; Nausea; Nitriles; Reference Values; Therapeutic Equivalency	2004
Entacapone improves the pharmacokinetic and therapeutic response of controlled release levodopa/carbidopa in Parkinson's patients. Journal of neural transmission (Vienna, Austria : 1996), 2004, Volume: 111, Issue:2 Topics: Aged; Area Under Curve; Carbidopa; Catechols; Cross-Over Studies; Delayed-Action Preparations; Female; Humans; Levodopa; Male; Middle Aged; Nitriles; Parkinson Disease; Single-Blind Method	2004
Temporal administration of entacapone with slow release L-dopa: pharmacokinetic profile and clinical outcome. Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 2004, Volume: 25, Issue:2 Topics: Aged; Analysis of Variance; Antiparkinson Agents; Area Under Curve; Biological Availability; Carbidopa; Catechol O-Methyltransferase Inhibitors; Catechols; Delayed-Action Preparations; Drug Administration Schedule; Drug Interactions; Drug Therapy, Combination; Enzyme Inhibitors; Female; Humans; Levodopa; Male; Middle Aged; Nitriles; Parkinson Disease; Single-Blind Method; Treatment Outcome	2004
Delayed administration may improve entacapone effects in parkinsonian patients non-responding to the drug. European journal of neurology, 2004, Volume: 11, Issue:9 Topics: Aged; Antiparkinson Agents; Area Under Curve; Biological Availability; Carbidopa; Catechols; Chromatography, High Pressure Liquid; Double-Blind Method; Drug Interactions; Drug Resistance; Female; Humans; Levodopa; Male; Middle Aged; Nitriles; Parkinson Disease	2004
The effect of entacapone on homocysteine levels in Parkinson disease. Neurology, 2005, Apr-26, Volume: 64, Issue:8 Topics: Aged; Aged, 80 and over; Antiparkinson Agents; Carbidopa; Catechol O-Methyltransferase; Catechol O-Methyltransferase Inhibitors; Catechols; Cohort Studies; Drug Interactions; Drug Therapy, Combination; Enzyme Inhibitors; Female; Homocysteine; Humans; Hyperhomocysteinemia; Levodopa; Male; Middle Aged; Nitriles; Treatment Outcome	2005
Treatment of end-of-dose wearing-off in parkinson's disease: stalevo (levodopa/carbidopa/entacapone) and levodopa/DDCI given in combination with Comtess/Comtan (entacapone) provide equivalent improvements in symptom control superior to that of traditional European neurology, 2005, Volume: 53, Issue:4 Topics: Aged; Antiparkinson Agents; Carbidopa; Catechols; Disability Evaluation; Drug Combinations; Drug Evaluation; Drug Therapy, Combination; Enzyme Inhibitors; Female; Follow-Up Studies; Humans; Levodopa; Male; Middle Aged; Motor Activity; Nitriles; Pain Measurement; Parkinson Disease; Quality of Life; Severity of Illness Index; Single-Blind Method; Surveys and Questionnaires; Treatment Outcome	2005
Motor deficits in Parkinsonian reaching: dopa-sensitivity influenced by real-world task constraint. Journal of motor behavior, 2006, Volume: 38, Issue:1 Topics: Activities of Daily Living; Aged; Amantadine; Antiparkinson Agents; Arm; Benzothiazoles; Biomechanical Phenomena; Carbidopa; Catechols; Dopamine Agents; Drug Therapy, Combination; Female; Humans; Levodopa; Male; Middle Aged; Motor Skills; Movement; Nitriles; Parkinson Disease; Pramipexole; Thiazoles	2006
Pharmacokinetic behaviour of levodopa and 3-O-methyldopa after repeat administration of levodopa/carbidopa with and without entacapone in patients with Parkinson's disease. Journal of neural transmission (Vienna, Austria : 1996), 2006, Volume: 113, Issue:10 Topics: Adult; Aged; Antiparkinson Agents; Area Under Curve; Carbidopa; Catechols; Chromatography, High Pressure Liquid; Female; Humans; Levodopa; Male; Middle Aged; Motor Activity; Nitriles; Parkinson Disease; Tyrosine	2006
Patient satisfaction with switching to Stalevo: an open-label evaluation in PD patients experiencing wearing-off (Simcom Study). Acta neurologica Scandinavica, 2006, Volume: 114, Issue:3 Topics: Adult; Aged; Antiparkinson Agents; Aromatic Amino Acid Decarboxylase Inhibitors; Carbidopa; Catechols; Cross-Over Studies; Drug Combinations; Female; Humans; Levodopa; Male; Middle Aged; Nitriles; Parkinson Disease; Patient Satisfaction; Treatment Outcome	2006
Comparison of 200 mg retarded release levodopa/carbidopa - with 150 mg levodopa/carbidopa/entacapone application: pharmacokinetics and efficacy in patients with Parkinson's disease. Journal of neural transmission (Vienna, Austria : 1996), 2007, Volume: 114, Issue:11 Topics: Adult; Aged; Antiparkinson Agents; Carbidopa; Catechols; Delayed-Action Preparations; Double-Blind Method; Drug Combinations; Female; Humans; Levodopa; Male; Middle Aged; Nitriles; Parkinson Disease; Tyrosine	2007
Entacapone improves absorption of a coadministered salt in patients with Parkinson's disease. Movement disorders : official journal of the Movement Disorder Society, 2008, Jul-30, Volume: 23, Issue:10 Topics: Adult; Aged; Antiparkinson Agents; Breath Tests; Caprylates; Carbidopa; Carbon Isotopes; Catechol O-Methyltransferase Inhibitors; Catechols; Drug Interactions; Drug Therapy, Combination; Enzyme Inhibitors; Female; Gastric Emptying; Humans; Intestinal Absorption; Levodopa; Male; Middle Aged; Nitriles; Parkinson Disease; Solubility	2008
Quality of life in early Parkinson's disease treated with levodopa/carbidopa/entacapone. Movement disorders : official journal of the Movement Disorder Society, 2009, Jan-15, Volume: 24, Issue:1 Topics: Aged; Antiparkinson Agents; Benserazide; Carbidopa; Catechol O-Methyltransferase Inhibitors; Catechols; Double-Blind Method; Drug Therapy, Combination; Dyskinesia, Drug-Induced; Enzyme Inhibitors; Female; Gastrointestinal Diseases; Humans; Levodopa; Male; Middle Aged; Nitriles; Parkinson Disease; Quality of Life; Severity of Illness Index; Treatment Outcome	2009
Double-blind trial of levodopa/carbidopa/entacapone versus levodopa/carbidopa in early Parkinson's disease. Movement disorders : official journal of the Movement Disorder Society, 2009, Mar-15, Volume: 24, Issue:4 Topics: Adult; Aged; Aged, 80 and over; Antiparkinson Agents; Carbidopa; Catechols; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Levodopa; Male; Middle Aged; Nitriles; Outcome Assessment, Health Care; Parkinson Disease; Severity of Illness Index	2009
Comparison of pharmacokinetic profile of levodopa throughout the day between levodopa/carbidopa/entacapone and levodopa/carbidopa when administered four or five times daily. European journal of clinical pharmacology, 2009, Volume: 65, Issue:5 Topics: Administration, Oral; Adolescent; Adult; Antiparkinson Agents; Area Under Curve; Carbidopa; Case-Control Studies; Catechol O-Methyltransferase; Catechol O-Methyltransferase Inhibitors; Catechols; Cross-Over Studies; Dose-Response Relationship, Drug; Drug Combinations; Drug Interactions; Female; Half-Life; Humans; Levodopa; Male; Metabolic Clearance Rate; Nitriles; Young Adult	2009
Pharmacokinetic-pharmacodynamic crossover comparison of two levodopa extension strategies. Movement disorders : official journal of the Movement Disorder Society, 2009, Jul-15, Volume: 24, Issue:9 Topics: Aged; Analysis of Variance; Antiparkinson Agents; Carbidopa; Catechols; Cross-Over Studies; Disability Evaluation; Dose-Response Relationship, Drug; Drug Delivery Systems; Drug Therapy, Combination; Female; Humans; Levodopa; Male; Middle Aged; Nitriles; Parkinson Disease; Retrospective Studies; Severity of Illness Index; Time Factors	2009
Direct switch from levodopa/benserazide or levodopa/carbidopa to levodopa/carbidopa/entacapone in Parkinson's disease patients with wearing-off: efficacy, safety and feasibility--an open-label, 6-week study. Journal of neural transmission (Vienna, Austria : 1996), 2010, Volume: 117, Issue:3 Topics: Aged; Antiparkinson Agents; Benserazide; Carbidopa; Catechols; Drug-Related Side Effects and Adverse Reactions; Dyskinesias; Feasibility Studies; Female; Humans; Levodopa; Male; Nitriles; Parkinson Disease; Severity of Illness Index; Surveys and Questionnaires; Treatment Outcome	2010
Effects of carbidopa and entacapone on the metabolic fate of the norepinephrine prodrug L-DOPS. Journal of clinical pharmacology, 2011, Volume: 51, Issue:1 Topics: Aged; Antiparkinson Agents; Blood Pressure; Carbidopa; Catechols; Double-Blind Method; Droxidopa; Drug Interactions; Female; Humans; Male; Middle Aged; Multiple System Atrophy; Nitriles; Norepinephrine; Parkinson Disease; Prodrugs; Pure Autonomic Failure; Vasoconstriction	2011
Initiating levodopa/carbidopa therapy with and without entacapone in early Parkinson disease: the STRIDE-PD study. Annals of neurology, 2010, Volume: 68, Issue:1 Topics: Antiparkinson Agents; Carbidopa; Catechol O-Methyltransferase Inhibitors; Catechols; Disease Progression; Dopamine Agents; Double-Blind Method; Drug Therapy, Combination; Dyskinesia, Drug-Induced; Enzyme Inhibitors; Female; Humans; Levodopa; Male; Middle Aged; Nitriles; Parkinson Disease; Risk; Time Factors; Treatment Outcome	2010
A double-blind, randomized, placebo and active-controlled study of nebicapone for the treatment of motor fluctuations in Parkinson's disease. CNS neuroscience & therapeutics, 2010, Volume: 16, Issue:6 Topics: Acetophenones; Adult; Aged; Aged, 80 and over; Antiparkinson Agents; Benserazide; Carbidopa; Catechol O-Methyltransferase Inhibitors; Catechols; Double-Blind Method; Endpoint Determination; Enzyme Inhibitors; Female; Humans; Levodopa; Male; Middle Aged; Nitriles; Parkinson Disease; Treatment Outcome	2010
Night-time bioavailability of levodopa/carbidopa/entacapone is higher compared to controlled-release levodopa/carbidopa. International journal of clinical pharmacology and therapeutics, 2010, Volume: 48, Issue:11 Topics: Adolescent; Adult; Antiparkinson Agents; Area Under Curve; Biological Availability; Carbidopa; Catechols; Cross-Over Studies; Delayed-Action Preparations; Drug Administration Schedule; Drug Combinations; Female; Half-Life; Humans; Levodopa; Male; Nitriles; Time Factors; Young Adult	2010
Inhibition of catechol-O-methyltransferase modifies acute homocysteine rise during repeated levodopa application in patients with Parkinson's disease. Naunyn-Schmiedeberg's archives of pharmacology, 2011, Volume: 383, Issue:6 Topics: Aged; Antiparkinson Agents; Aromatic Amino Acid Decarboxylase Inhibitors; Biological Availability; Carbidopa; Catechol O-Methyltransferase Inhibitors; Catechols; Drug Combinations; Drug Therapy, Combination; Female; Half-Life; Homocysteine; Humans; Levodopa; Male; Middle Aged; Nitriles; Parkinson Disease; Tyrosine	2011
Immediate versus delayed switch from levodopa/carbidopa to levodopa/carbidopa/entacapone: effects on motor function and quality of life in patients with Parkinson's disease with end-of-dose wearing off. The International journal of neuroscience, 2011, Volume: 121, Issue:11 Topics: Adult; Aged; Aged, 80 and over; Antiparkinson Agents; Carbidopa; Catechols; Drug Administration Schedule; Drug Therapy, Combination; Female; Humans; Levodopa; Male; Middle Aged; Nitriles; Parkinson Disease; Prospective Studies; Quality of Life; Single-Blind Method	2011
The effect of different dosing regimens of levodopa/carbidopa/entacapone on plasma levodopa concentrations. European journal of clinical pharmacology, 2012, Volume: 68, Issue:3 Topics: Adult; Antiparkinson Agents; Area Under Curve; Carbidopa; Catechols; Cross-Over Studies; Dopamine Agents; Drug Combinations; Drug Interactions; Female; Humans; Levodopa; Male; Nitriles; Young Adult	2012
Frequent administration of levodopa/carbidopa microtablets vs levodopa/carbidopa/entacapone in healthy volunteers. Acta neurologica Scandinavica, 2013, Volume: 127, Issue:2 Topics: Adult; Carbidopa; Catechols; Cross-Over Studies; Drug Combinations; Female; Humans; Levodopa; Male; Nitriles; Tablets; Young Adult	2013
Ropinirole does not affect plasma arginine vasopressin levels in patients with advanced Parkinson's disease. Neuro endocrinology letters, 2012, Volume: 33, Issue:7 Topics: Aged; Arginine Vasopressin; Carbidopa; Catechols; Dopamine Agonists; Dose-Response Relationship, Drug; Drug Combinations; Drug Therapy, Combination; Female; Humans; Inappropriate ADH Syndrome; Indoles; Levodopa; Male; Middle Aged; Nitriles; Parkinson Disease	2012
Efficacy of levodopa/carbidopa/entacapone versus levodopa/carbidopa in patients with early Parkinson's disease experiencing mild wearing-off: a randomised, double-blind trial. Journal of neural transmission (Vienna, Austria : 1996), 2014, Volume: 121, Issue:4 Topics: Adult; Aged; Aged, 80 and over; Antiparkinson Agents; Carbidopa; Catechols; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Levodopa; Male; Middle Aged; Nitriles; Parkinson Disease; Retrospective Studies; Severity of Illness Index; Surveys and Questionnaires	2014
Comparison of IPX066 with carbidopa-levodopa plus entacapone in advanced PD patients. Parkinsonism & related disorders, 2014, Volume: 20, Issue:12 Topics: Aged; Antiparkinson Agents; Carbidopa; Catechols; Cross-Over Studies; Dose-Response Relationship, Drug; Double-Blind Method; Drug Administration Schedule; Drug Combinations; Female; Humans; Levodopa; Male; Middle Aged; Nitriles; Parkinson Disease; Treatment Outcome; Walking	2014
Efficacy and safety of entacapone in levodopa/carbidopa versus levodopa/benserazide treated Parkinson's disease patients with wearing-off. Journal of neural transmission (Vienna, Austria : 1996), 2015, Volume: 122, Issue:12 Topics: Antiparkinson Agents; Benserazide; Carbidopa; Catechol O-Methyltransferase Inhibitors; Catechols; Data Interpretation, Statistical; Double-Blind Method; Drug Combinations; Drug Therapy, Combination; Female; Humans; Levodopa; Male; Middle Aged; Nitriles; Parkinson Disease; Retrospective Studies; Treatment Outcome	2015
Conversion to IPX066 from Standard Levodopa Formulations in Advanced Parkinson's Disease: Experience in Clinical Trials. Journal of Parkinson's disease, 2015, Volume: 5, Issue:4 Topics: Aged; Antiparkinson Agents; Carbidopa; Catechols; Cross-Over Studies; Double-Blind Method; Drug Administration Schedule; Drug Combinations; Female; Humans; Levodopa; Male; Middle Aged; Nitriles; Outcome Assessment, Health Care; Parkinson Disease; Treatment Outcome	2015
Levodopa-entacapone-carbidopa intestinal gel in Parkinson's disease: A randomized crossover study. Movement disorders : official journal of the Movement Disorder Society, 2017, Volume: 32, Issue:2 Topics: Aged; Antiparkinson Agents; Carbidopa; Catechols; Cross-Over Studies; Drug Combinations; Female; Humans; Infusions, Parenteral; Levodopa; Male; Nitriles; Parkinson Disease; Treatment Outcome	2017
Population pharmacokinetics of levodopa gel infusion in Parkinson's disease: effects of entacapone infusion and genetic polymorphism. Scientific reports, 2020, 10-22, Volume: 10, Issue:1 Topics: Carbidopa; Catechol O-Methyltransferase; Catechols; Cross-Over Studies; Dopa Decarboxylase; Double-Blind Method; Drug Combinations; Drug Delivery Systems; Female; Gels; Genotype; Humans; Levodopa; Male; Models, Biological; Nitriles; Parkinson Disease; Polymorphism, Genetic	2020
ND0612 (levodopa/carbidopa for subcutaneous infusion) in patients with Parkinson's disease and motor response fluctuations: A randomized, placebo-controlled phase 2 study. Parkinsonism & related disorders, 2021, Volume: 91 Topics: Administration, Oral; Aged; Antiparkinson Agents; Carbidopa; Catechols; Double-Blind Method; Drug Combinations; Drug Therapy, Combination; Female; Humans; Infusions, Subcutaneous; Levodopa; Male; Middle Aged; Motor Activity; Nitriles; Parkinson Disease; Proof of Concept Study; Treatment Outcome	2021
Effect of Carbidopa Dose on Levodopa Pharmacokinetics With and Without Catechol-O-Methyltransferase Inhibition in Healthy Subjects. European journal of drug metabolism and pharmacokinetics, 2023, Volume: 48, Issue:1 Topics: Antiparkinson Agents; Carbidopa; Catechol O-Methyltransferase; Catechol O-Methyltransferase Inhibitors; Healthy Volunteers; Humans; Levodopa; Parkinson Disease	2023

Other Studies

54 other study(ies) available for carbidopa and entacapone

Article	Year
Developing structure-activity relationships for the prediction of hepatotoxicity. Chemical research in toxicology, 2010, Jul-19, Volume: 23, Issue:7 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; Tetracyclines; Thiophenes	2010
A predictive ligand-based Bayesian model for human drug-induced liver injury. Drug metabolism and disposition: the biological fate of chemicals, 2010, Volume: 38, Issue:12 Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands	2010
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development. Toxicological sciences : an official journal of the Society of Toxicology, 2013, Volume: 136, Issue:1 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests	2013
Different in vivo properties of three new inhibitors of catechol O-methyltransferase in the rat. British journal of pharmacology, 1992, Volume: 105, Issue:3 Topics: Amidines; Animals; Benzophenones; Biogenic Monoamines; Brain; Carbidopa; Catechol O-Methyltransferase Inhibitors; Catechols; Corpus Striatum; Homovanillic Acid; Hypothalamus; Levodopa; Male; Methyldopa; Nitriles; Nitrophenols; Pyridones; Rats; Rats, Inbred Strains; Tolcapone	1992
Acute toxicity of three new selective COMT inhibitors in mice with special emphasis on interactions with drugs increasing catecholaminergic neurotransmission. Pharmacology & toxicology, 1991, Volume: 69, Issue:1 Topics: Amphetamine; Animals; Benzophenones; Carbidopa; Catechol O-Methyltransferase Inhibitors; Catecholamines; Catechols; Clorgyline; Convulsants; Desipramine; Drug Interactions; Lethal Dose 50; Levodopa; Male; Mice; Motor Activity; Nitriles; Nomifensine; Pentanones; Selegiline; Synaptic Transmission; Yohimbine	1991
Comparison of two new inhibitors of catechol O-methylation on striatal dopamine metabolism: a microdialysis study in rats. British journal of pharmacology, 1994, Volume: 112, Issue:1 Topics: 3,4-Dihydroxyphenylacetic Acid; Amidines; Animals; Biogenic Monoamines; Carbidopa; Catechol O-Methyltransferase Inhibitors; Catechols; Dopamine; Homovanillic Acid; Hydroxyindoleacetic Acid; Levodopa; Male; Microdialysis; Neostriatum; Nitriles; Pyridones; Rats; Rats, Wistar; Stereotaxic Techniques; Tryptophan; Tyrosine	1994
Beneficial effects of co-administration of catechol-O-methyltransferase inhibitors and L-dihydroxyphenylalanine in rat models of depression. European journal of pharmacology, 1995, Feb-14, Volume: 274, Issue:1-3 Topics: Analysis of Variance; Animals; Avoidance Learning; Behavior, Animal; Benzophenones; Carbidopa; Catechol O-Methyltransferase Inhibitors; Catechols; Depression; Desipramine; Dihydroxyphenylalanine; Disease Models, Animal; Drug Synergism; Drug Therapy, Combination; Levodopa; Male; Motor Activity; Nitriles; Nitrophenols; Rats; Rats, Wistar; Swimming; Tolcapone	1995
The effect of carbidopa and entacapone pretreatment on the L-dopa pharmacokinetics and metabolism in blood plasma and skeletal muscle in beagle dog: an in vivo microdialysis study. The Journal of pharmacology and experimental therapeutics, 1995, Volume: 273, Issue:3 Topics: Animals; Carbidopa; Catechols; Dogs; Extracellular Space; Levodopa; Male; Microdialysis; Muscle, Skeletal; Nitriles; Premedication	1995
Effect of catechol-O-methyl transferase inhibition on peripheral and central metabolism of 6-[18F]fluoro-L-dopa. European journal of pharmacology, 1994, May-12, Volume: 257, Issue:1-2 Topics: Animals; Carbidopa; Catechol O-Methyltransferase Inhibitors; Catechols; Cerebellum; Chromatography, High Pressure Liquid; Corpus Striatum; Dihydroxyphenylalanine; Fluorine Radioisotopes; Male; Nitriles; Rats; Rats, Wistar	1994
Effects of three types of catechol O-methylation inhibitors on L-3,4-dihydroxyphenylalanine-induced circling behaviour in rats. European journal of pharmacology, 1993, Nov-30, Volume: 250, Issue:1 Topics: Amidines; Amphetamine; Animals; Behavior, Animal; Benzophenones; Carbidopa; Catechol O-Methyltransferase Inhibitors; Catechols; Clorgyline; Drug Interactions; Drug Synergism; Levodopa; Male; Methylation; Nitriles; Nitrophenols; Pyridones; Rats; Rats, Wistar; Tolcapone	1993
Effects of catechol-O-methyltransferase inhibitors and L-3,4-dihydroxyphenylalanine with or without carbidopa on extracellular dopamine in rat striatum. Journal of neurochemistry, 1993, Volume: 60, Issue:1 Topics: Animals; Benzophenones; Carbidopa; Catechol O-Methyltransferase Inhibitors; Catechols; Corpus Striatum; Dihydroxyphenylalanine; Dopamine; Extracellular Space; Male; Nitriles; Nitrophenols; Rats; Rats, Sprague-Dawley; Tolcapone; Tyrosine	1993
The effect of catechol-O-methyl transferase inhibition by entacapone on the pharmacokinetics and metabolism of levodopa in healthy volunteers. Clinical neuropharmacology, 1993, Volume: 16, Issue:2 Topics: 3,4-Dihydroxyphenylacetic Acid; Adult; Carbidopa; Catechol O-Methyltransferase; Catechol O-Methyltransferase Inhibitors; Catechols; Electrocardiography; Half-Life; Homovanillic Acid; Humans; Levodopa; Male; Nitriles; Reference Values; Tyrosine	1993
Entacapone enhances levodopa-induced reversal of motor disability in MPTP-treated common marmosets. Movement disorders : official journal of the Movement Disorder Society, 1997, Volume: 12, Issue:6 Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Callithrix; Carbidopa; Catechols; Dopamine Agonists; Dose-Response Relationship, Drug; Drug Synergism; Drug Therapy, Combination; Enzyme Inhibitors; Female; Levodopa; Male; Movement Disorders; Nitriles; Severity of Illness Index	1997
The central catechol-O-methyltransferase inhibitor tolcapone increases striatal hydroxyl radical production in L-DOPA/carbidopa treated rats. Journal of neural transmission (Vienna, Austria : 1996), 2001, Volume: 108, Issue:2 Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Antiparkinson Agents; Benzophenones; Carbidopa; Catechol O-Methyltransferase Inhibitors; Catechols; Corpus Striatum; Dopamine; Dose-Response Relationship, Drug; Hydroxyl Radical; Levodopa; Male; Microdialysis; Nitriles; Nitrophenols; Oxidative Stress; Parkinsonian Disorders; Rats; Rats, Wistar; Tolcapone	2001
Chronic high dose L-DOPA alone or in combination with the COMT inhibitor entacapone does not increase oxidative damage or impair the function of the nigro-striatal pathway in normal cynomologus monkeys. Journal of neural transmission (Vienna, Austria : 1996), 2002, Volume: 109, Issue:1 Topics: Animals; Antiparkinson Agents; Carbidopa; Catechol O-Methyltransferase Inhibitors; Catechols; Cerebral Cortex; Corpus Striatum; DNA Damage; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Synergism; Levodopa; Macaca fascicularis; Mazindol; Neural Pathways; Nitriles; Oxidative Stress; Reference Values; RNA, Messenger; Substantia Nigra; Tyrosine 3-Monooxygenase	2002
Entacapone in restless legs syndrome. Movement disorders : official journal of the Movement Disorder Society, 2002, Volume: 17, Issue:2 Topics: Antiparkinson Agents; Carbidopa; Catechols; Delayed-Action Preparations; Drug Combinations; Drug Therapy, Combination; Female; Humans; Levodopa; Middle Aged; Neurologic Examination; Nitriles; Restless Legs Syndrome	2002
Effect of pulsatile administration of levodopa on dyskinesia induction in drug-naïve MPTP-treated common marmosets: effect of dose, frequency of administration, and brain exposure. Movement disorders : official journal of the Movement Disorder Society, 2003, Volume: 18, Issue:5 Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Antiparkinson Agents; Callithrix; Carbidopa; Catechols; Dose-Response Relationship, Drug; Drug Synergism; Drug Therapy, Combination; Dyskinesia, Drug-Induced; Female; Levodopa; Locomotion; Male; Nitriles; Parkinsonian Disorders; Pulse Therapy, Drug; Substantia Nigra; Time Factors	2003
Stalevo for Parkinson's disease. The Medical letter on drugs and therapeutics, 2004, May-10, Volume: 46, Issue:1182 Topics: Carbidopa; Catechols; Diarrhea; Dose-Response Relationship, Drug; Drug Combinations; Humans; Levodopa; Nausea; Nitriles; Parkinson Disease	2004
Multiple small doses of levodopa plus entacapone produce continuous dopaminergic stimulation and reduce dyskinesia induction in MPTP-treated drug-naive primates. Movement disorders : official journal of the Movement Disorder Society, 2005, Volume: 20, Issue:3 Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Antiparkinson Agents; Callithrix; Carbidopa; Catechols; Dopamine Agents; Drug Administration Schedule; Drug Therapy, Combination; Dyskinesia, Drug-Induced; Female; Injections, Subcutaneous; Levodopa; Locomotion; Male; MPTP Poisoning; Nitriles; Severity of Illness Index; Substantia Nigra; Time Factors	2005
Inhibition of catechol-O-methyltransferase contributes to more stable levodopa plasma levels. Movement disorders : official journal of the Movement Disorder Society, 2006, Volume: 21, Issue:3 Topics: Adult; Aged; Antiparkinson Agents; Carbidopa; Catechol O-Methyltransferase Inhibitors; Catechols; Dopamine Agonists; Drug Combinations; Drug Therapy, Combination; Female; Humans; Levodopa; Male; Middle Aged; Nitriles; Parkinson Disease	2006
Levodopa/carbidopa/entacapone-induced acute Pisa syndrome in a Parkinson's disease patient. Journal of the neurological sciences, 2008, Dec-15, Volume: 275, Issue:1-2 Topics: Antiparkinson Agents; Carbidopa; Catechols; Dystonic Disorders; Humans; Levodopa; Male; Middle Aged; Nitriles; Parkinson Disease; Tomography, Emission-Computed, Single-Photon; Tropanes	2008
Effective control of catatonia in Parkinson's disease by electroconvulsive therapy: a case report. European journal of neurology, 2009, Volume: 16, Issue:2 Topics: Aged; Antiparkinson Agents; Azepines; Benzothiazoles; Cabergoline; Carbidopa; Catatonia; Catechols; Drug Therapy, Combination; Electroconvulsive Therapy; Ergolines; Female; Humans; Levodopa; Nitriles; Parkinson Disease; Pramipexole	2009
Levodopa/carbidopa/entacapone in Parkinson's disease. Expert review of neurotherapeutics, 2009, Volume: 9, Issue:7 Topics: Antiparkinson Agents; Biological Availability; Carbidopa; Catechols; Clinical Trials as Topic; Dose-Response Relationship, Drug; Drug Therapy, Combination; Humans; Levodopa; Nitriles; Parkinson Disease	2009
Peripheral COMT inhibition prevents levodopa associated homocysteine increase. Journal of neural transmission (Vienna, Austria : 1996), 2009, Volume: 116, Issue:10 Topics: Adult; Aged; Aged, 80 and over; Antiparkinson Agents; Carbidopa; Catechol O-Methyltransferase Inhibitors; Catechols; Delayed-Action Preparations; Dihydroxyphenylalanine; Enzyme Inhibitors; Female; Homocysteine; Humans; Levodopa; Male; Middle Aged; Nitriles; Parkinson Disease; Time Factors; Tyrosine	2009
Adherence with levodopa/carbidopa/entacapone versus levodopa/carbidopa and entacapone as separate tablets in patients with Parkinson's disease. Current medical research and opinion, 2010, Volume: 26, Issue:7 Topics: Aged; Aged, 80 and over; Algorithms; Antiparkinson Agents; Carbidopa; Catechols; Cohort Studies; Dosage Forms; Drug Combinations; Female; Humans; Levodopa; Male; Middle Aged; Nitriles; Parkinson Disease; Patient Compliance; Retrospective Studies; Tablets	2010
Treatment of advanced Parkinson's disease in the United States: a cost-utility model. Clinical drug investigation, 2010, Volume: 30, Issue:11 Topics: Antiparkinson Agents; Carbidopa; Catechols; Cost Savings; Cost-Benefit Analysis; Disease Progression; Drug Administration Schedule; Drug Costs; Drug Therapy, Combination; Humans; Indans; Levodopa; Markov Chains; Models, Economic; Nitriles; Parkinson Disease; Quality of Life; Quality-Adjusted Life Years; Stochastic Processes; Time Factors; Treatment Outcome; United States	2010
Determination of L-dopa, carbidopa, 3-O-methyldopa and entacapone in human plasma by HPLC-ED. Journal of pharmaceutical and biomedical analysis, 2011, Feb-20, Volume: 54, Issue:3 Topics: Antiparkinson Agents; Calibration; Carbidopa; Catechols; Chromatography, High Pressure Liquid; Drug Combinations; Humans; Levodopa; Methyldopa; Nitriles; Reproducibility of Results; Solid Phase Extraction	2011
Parkinson disease: adjunctive entacapone therapy increases risk of dyskinesia. Nature reviews. Neurology, 2010, Volume: 6, Issue:11 Topics: Antiparkinson Agents; Carbidopa; Catechols; Corpus Striatum; Dopamine; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Combinations; Drug Therapy, Combination; Humans; Levodopa; Neurologic Examination; Nitriles; Parkinson Disease; Randomized Controlled Trials as Topic; Receptors, Dopamine	2010
The association between adherence to levodopa/carbidopa/entacapone therapy and healthcare utilization and costs among patients with Parkinson's disease: a retrospective claims-based analysis. CNS drugs, 2011, Volume: 25, Issue:1 Topics: Antiparkinson Agents; Carbidopa; Catechols; Cohort Studies; Delivery of Health Care; Health Care Costs; Humans; Levodopa; Nitriles; Parkinson Disease; Patient Compliance; Retrospective Studies	2011
Relationship between 3-O-methyldopa and the clinical effects of entacapone in advanced Parkinson's disease. Hiroshima journal of medical sciences, 2011, Volume: 60, Issue:3 Topics: Aged; Aged, 80 and over; Antiparkinson Agents; Aromatic Amino Acid Decarboxylase Inhibitors; Benserazide; Biomarkers; Carbidopa; Catechol O-Methyltransferase; Catechol O-Methyltransferase Inhibitors; Catechols; Disease Progression; Dopa Decarboxylase; Drug Therapy, Combination; Enzyme Inhibitors; Female; Humans; Japan; Levodopa; Male; Middle Aged; Motor Activity; Nitriles; Parkinson Disease; Prospective Studies; Treatment Outcome; Tyrosine	2011
Finasteride attenuates pathological gambling in patients with Parkinson disease. Journal of clinical psychopharmacology, 2012, Volume: 32, Issue:3 Topics: 5-alpha Reductase Inhibitors; Aged; Antiparkinson Agents; Benzothiazoles; Cabergoline; Carbidopa; Catechols; Drug Combinations; Drug Monitoring; Drug Therapy, Combination; Ergolines; Finasteride; Gambling; Humans; Levodopa; Male; Middle Aged; Nitriles; Parkinson Disease; Pramipexole; Treatment Outcome; Video Games	2012
Treatment of Parkinson disease: a 64-year-old man with motor complications of advanced Parkinson disease. JAMA, 2012, Jun-06, Volume: 307, Issue:21 Topics: Amantadine; Antiparasitic Agents; Carbidopa; Catechols; Decision Making; Deep Brain Stimulation; Disease Progression; Dyskinesia, Drug-Induced; Gait Disorders, Neurologic; Globus Pallidus; Humans; Levodopa; Male; Middle Aged; Nitriles; Parkinson Disease; Quality of Life; Subthalamus	2012
Drugs for treating Parkinson disease. Nursing, 2012, Volume: 42, Issue:7 Topics: Antiparkinson Agents; Apomorphine; Carbidopa; Catechols; Drug Combinations; Drugs, Generic; Humans; Indans; Levodopa; Nitriles; Parkinson Disease	2012
Foot dystonia heralding levodopa-induced dyskinesias in Parkinson disease. Clinical neurology and neurosurgery, 2013, Volume: 115, Issue:2 Topics: Antiparkinson Agents; Carbidopa; Catechols; Dyskinesia, Drug-Induced; Dystonia; Female; Foot Diseases; Humans; Levodopa; Middle Aged; Neurologic Examination; Nitriles; Parkinson Disease	2013
Chaotropic agents in liquid chromatographic method development for the simultaneous analysis of levodopa, carbidopa, entacapone and their impurities. Journal of pharmaceutical and biomedical analysis, 2013, Apr-15, Volume: 77 Topics: Antiparkinson Agents; Carbidopa; Catechols; Chromatography, Reverse-Phase; Drug Contamination; Levodopa; Nitriles; Particle Size; Reproducibility of Results; Sensitivity and Specificity; Trifluoroacetic Acid	2013
Clinical aspects of comorbid schizophrenia and idiopathic Parkinson's disease. Clinical schizophrenia & related psychoses, 2014, Volume: 8, Issue:1 Topics: Antiparkinson Agents; Antipsychotic Agents; Brain; Carbidopa; Catechols; Clozapine; Diagnosis, Differential; Fluphenazine; Follow-Up Studies; Humans; Levodopa; Male; Middle Aged; Nitriles; Parkinson Disease; Schizophrenia; Tomography, Emission-Computed, Single-Photon; Treatment Outcome	2014
Factors determining when to start levodopa/carbidopa/entacapone treatment in Spanish patients with Parkinson's disease. Neurologia (Barcelona, Spain), 2014, Volume: 29, Issue:3 Topics: Aged; Antiparkinson Agents; Carbidopa; Catechols; Cross-Sectional Studies; Drug Therapy, Combination; Female; Humans; Levodopa; Male; Middle Aged; Nitriles; Parkinson Disease; Retrospective Studies; Socioeconomic Factors; Spain	2014
Levodopa-related cysteinyl-glycine and cysteine reduction with and without catechol-O-methyltransferase inhibition in Parkinson's disease patients. Journal of neural transmission (Vienna, Austria : 1996), 2014, Volume: 121, Issue:6 Topics: Aged; Analysis of Variance; Antiparkinson Agents; Carbidopa; Catechol O-Methyltransferase; Catechols; Chromatography, Reverse-Phase; Cysteine; Dipeptides; Drug Delivery Systems; Female; Humans; Levodopa; Male; Methyldopa; Middle Aged; Nitriles; Parkinson Disease; Time Factors	2014
Fewer fluctuations, higher maximum concentration and better motor response of levodopa with catechol-O-methyltransferase inhibition. Journal of neural transmission (Vienna, Austria : 1996), 2014, Volume: 121, Issue:11 Topics: Aged; Antiparkinson Agents; Area Under Curve; Benzophenones; Carbidopa; Catechol O-Methyltransferase Inhibitors; Catechols; Dose-Response Relationship, Drug; Female; Humans; Levodopa; Male; Middle Aged; Motor Activity; Nitriles; Nitrophenols; Parkinson Disease; Psychomotor Performance; Statistics, Nonparametric; Tolcapone; Treatment Outcome	2014
Simultaneous determination of levodopa, carbidopa, entacapone, tolcapone, 3-O-methyldopa and dopamine in human plasma by an HPLC-MS/MS method. Bioanalysis, 2015, Volume: 7, Issue:2 Topics: Benzophenones; Blood Chemical Analysis; Carbidopa; Catechols; Chromatography, High Pressure Liquid; Dihydroxyphenylalanine; Dopamine; Humans; Levodopa; Nitriles; Nitrophenols; Quality Control; Reproducibility of Results; Tandem Mass Spectrometry; Tolcapone; Tyrosine	2015
Effects of levodopa-carbidopa-entacapone and smoked cocaine on facial affect recognition in cocaine smokers. Journal of psychopharmacology (Oxford, England), 2016, Volume: 30, Issue:4 Topics: Adult; Carbidopa; Catechols; Cocaine; Cocaine-Related Disorders; Drug Interactions; Face; Female; Humans; Levodopa; Male; Middle Aged; Nitriles; Smoke; Young Adult	2016
Multi-Drug-Loaded Microcapsules with Controlled Release for Management of Parkinson's Disease. Small (Weinheim an der Bergstrasse, Germany), 2016, Volume: 12, Issue:27 Topics: Animals; Caproates; Capsules; Carbidopa; Catechols; Delayed-Action Preparations; Drug Delivery Systems; Drug Liberation; Humans; Hydrophobic and Hydrophilic Interactions; Lactones; Levodopa; Microscopy, Confocal; Nitriles; Parkinson Disease; Polyesters	2016
Investigation of different spectrophotometric and chemometric methods for determination of entacapone, levodopa and carbidopa in ternary mixture. Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 2017, Jan-15, Volume: 171 Topics: Calibration; Carbidopa; Catechols; Least-Squares Analysis; Levodopa; Limit of Detection; Nitriles; Principal Component Analysis; Reproducibility of Results; Spectrophotometry	2017
Cathecol-O-methyltransferase inhibitors: another possibly useful pharmacological tool for treating Parkinson's disease in pregnancy? Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology, 2017, Volume: 37, Issue:3 Topics: Adult; Carbidopa; Catechol O-Methyltransferase; Catechol O-Methyltransferase Inhibitors; Catechols; Cesarean Section; Female; Gestational Age; Humans; Infant, Newborn; Levodopa; Nitriles; Parkinson Disease; Pregnancy; Pregnancy Complications; Pregnancy Outcome	2017
Development and Validation of a Robust and Efficient HPLC Method for the Simultaneous Quantification of Levodopa, Carbidopa, Benserazide and Entacapone in Complex Matrices. Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques, 2017, Volume: 20, Issue:0 Topics: Antiparkinson Agents; Benserazide; Carbidopa; Catechols; Chromatography, High Pressure Liquid; Levodopa; Molecular Structure; Nitriles	2017
Improved Bioavailability of Levodopa Using Floatable Spray-Coated Microcapsules for the Management of Parkinson's Disease. Neuromolecular medicine, 2018, Volume: 20, Issue:2 Topics: Administration, Oral; Animals; Antiparkinson Agents; Biological Availability; Brain Chemistry; Capsules; Carbidopa; Catechols; Dopamine; Drug Compounding; Female; Hydrophobic and Hydrophilic Interactions; Levodopa; Mice; Mice, Inbred C57BL; Microscopy, Electron, Scanning; Nitriles; Parkinson Disease	2018
Micellar HPLC-UV method for the simultaneous determination of levodopa, carbidopa and entacapone in pharmaceuticals and human plasma. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2018, Aug-01, Volume: 1091 Topics: Adult; Carbidopa; Catechols; Chromatography, High Pressure Liquid; Humans; Levodopa; Limit of Detection; Linear Models; Male; Nitriles; Reproducibility of Results; Spectrophotometry, Ultraviolet; Tablets	2018
Managing treatment fluctuations in Parkinson disease: "On" again-, "off" again. Neurology, 2019, 03-26, Volume: 92, Issue:13 Topics: Carbidopa; Catechols; Humans; Levodopa; Nitriles; Parkinson Disease	2019
Dyskinesia-Hyperpyrexia Syndrome in Parkinson's disease with Deep Brain Stimulation and high-dose levodopa/carbidopa and entacapone. Parkinsonism & related disorders, 2019, Volume: 64 Topics: Antiparkinson Agents; Carbidopa; Catechols; Combined Modality Therapy; Deep Brain Stimulation; Drug Combinations; Drug Therapy, Combination; Fever; Humans; Hyperkinesis; Levodopa; Male; Middle Aged; Nitriles; Parkinson Disease	2019
A rapid liquid chromatography/tandem mass spectrometry method for simultaneous determination of levodopa, carbidopa, entacapone and their six related compounds in film-coated tablets. Rapid communications in mass spectrometry : RCM, 2020, Jun-30, Volume: 34, Issue:12 Topics: Carbidopa; Catechols; Chromatography, High Pressure Liquid; Levodopa; Limit of Detection; Linear Models; Nitriles; Reproducibility of Results; Tablets; Tandem Mass Spectrometry	2020
Clinical Pharmacology of Entacapone (Comtan) From the FDA Reviewer. The international journal of neuropsychopharmacology, 2022, 08-04, Volume: 25, Issue:7 Topics: Antiparkinson Agents; Carbidopa; Catechol O-Methyltransferase; Catechols; Drug Therapy, Combination; Humans; Levodopa; Nitriles; Parkinson Disease; United States; United States Food and Drug Administration	2022
Effects of One-Day Application of Levodopa/Carbidopa/Entacapone versus Levodopa/Carbidopa/Opicapone in Parkinson's Disease Patients. Cells, 2022, 04-30, Volume: 11, Issue:9 Topics: Antiparkinson Agents; Aromatic Amino Acid Decarboxylase Inhibitors; Carbidopa; Catechol O-Methyltransferase; Catechol O-Methyltransferase Inhibitors; Catechols; Homocysteine; Humans; Levodopa; Nitriles; Oxadiazoles; Parkinson Disease	2022
Different dissolution conditions affect stability and dissolution profiles of bioequivalent levodopa-containing oral dosage forms. International journal of pharmaceutics, 2022, Dec-15, Volume: 629 Topics: Carbidopa; Drugs, Generic; Humans; Levodopa; Solubility; Therapeutic Equivalency	2022
Apprends-moi l'art des petits pas: Levodopa, Carbidopa Intestinal Gel plus Entacapone. Journal of neural transmission (Vienna, Austria : 1996), 2023, Volume: 130, Issue:11 Topics: Antiparkinson Agents; Carbidopa; Drug Combinations; Gels; Humans; Levodopa; Prospective Studies	2023