Page last updated: 2024-09-04

carbapenems and tomopenem

carbapenems has been researched along with tomopenem in 16 studies

Compound Research Comparison

Studies
(carbapenems)
Trials
(carbapenems)
Recent Studies (post-2010)
(carbapenems)
Studies
(tomopenem)
Trials
(tomopenem)
Recent Studies (post-2010) (tomopenem)
7,3551475,2771921

Research

Studies (16)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's13 (81.25)29.6817
2010's3 (18.75)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Moland, ES; Thomson, KS1
Abe, T; Fukuoka, T; Hirota, T; Inoue, H; Kakuta, M; Kitayama, A; Koga, T; Kuwahara, S; Masuda, N; Matsushita, Y; Nakagawa, M; Ohya, S; Shibayama, T; Sugihara, C; Takenouchi, T; Utsui, Y; Yoshida, T1
Hirota, T; Ikeda, T; Kuwahara, S; Matsushita, Y; Shibayama, T1
Hirota, T; Ikeda, T; Kawai, K; Kuwahara, S; Matsushita, Y; Shibayama, T1
Hirota, T; Ikeda, T; Matsushita, Y; Shibayama, T; Tokui, T; Yamamura, N1
Hirota, T; Ikeda, T; Kurihara, A; Matsushita, Y; Shibayama, T1
Hirota, T; Ikeda, T; Kamiyama, E; Shibayama, T; Sugiyama, D; Tokui, T1
Bowker, KE; MacGowan, AP; Noel, AR1
Davies, BE; Kirkpatrick, C; Lennon, S; Liu, M; Luedin, E; Mallalieu, NL; Robson, R1
Fukuoka, T; Kakuta, M; Koga, T; Masuda, N; Namba, E; Sugihara, C2
Izumikawa, K; Kakeya, H; Kamihira, S; Kohno, S; Morinaga, Y; Nakamura, S; Seki, M; Yamada, Y; Yamamoto, K; Yamamoto, Y; Yanagihara, K1
Davies, BE; Guy, T; Lennon, S; Liu, M; Luedin, E; Mallalieu, NL1
Kakuta, M; Koga, T; Sugihara, C; Sugihara, K; Tomozawa, T1
Inoue, H; Kakuta, M; Koga, T; Matsushita, Y; Namba, E; Nasu, H; Sugihara, C; Sugihara, K; Tokumitsu, A; Uemori, M; Yamamura, N1
Koga, T; Sugihara, C; Sugihara, K; Tateda, K; Yamaguchi, K; Yamamura, N1

Trials

2 trial(s) available for carbapenems and tomopenem

ArticleYear
Effect of impaired renal function on the pharmacokinetics of tomopenem (RO4908463/CS-023), a novel carbapenem.
    Antimicrobial agents and chemotherapy, 2008, Volume: 52, Issue:7

    Topics: Adult; Aged; Bacterial Infections; Carbapenems; Creatinine; Female; Humans; Infusions, Intravenous; Male; Metabolic Clearance Rate; Middle Aged; Renal Insufficiency

2008
Lack of age and gender effects on single-dose pharmacokinetics of tomopenem (RO4908463/CS-023), a novel carbapenem.
    British journal of clinical pharmacology, 2009, Volume: 67, Issue:4

    Topics: Adult; Age Factors; Aged; Area Under Curve; Carbapenems; Double-Blind Method; Female; Half-Life; Humans; Male; Metabolic Clearance Rate; Middle Aged; Sex Factors; Treatment Outcome; Young Adult

2009

Other Studies

14 other study(ies) available for carbapenems and tomopenem

ArticleYear
CS-023 (R-115685), a novel carbapenem with enhanced in vitro activity against oxacillin-resistant staphylococci and Pseudomonas aeruginosa.
    The Journal of antimicrobial chemotherapy, 2004, Volume: 54, Issue:2

    Topics: Anti-Infective Agents; Bacterial Infections; Carbapenems; Gram-Negative Bacteria; Gram-Positive Bacteria; Humans; Microbial Sensitivity Tests; Oxacillin; Penicillin Resistance; Penicillins; Pseudomonas aeruginosa; Staphylococcus; United States

2004
In vitro and in vivo antibacterial activities of CS-023 (RO4908463), a novel parenteral carbapenem.
    Antimicrobial agents and chemotherapy, 2005, Volume: 49, Issue:8

    Topics: Animals; Anti-Bacterial Agents; Carbapenems; Disease Models, Animal; Drug Resistance, Bacterial; Gram-Negative Bacteria; Gram-Negative Bacterial Infections; Gram-Positive Bacteria; Gram-Positive Bacterial Infections; Humans; Mice; Microbial Sensitivity Tests

2005
Pharmacokinetics of CS-023 (RO4908463), a novel parenteral carbapenem, in healthy male Caucasian volunteers.
    Antimicrobial agents and chemotherapy, 2006, Volume: 50, Issue:12

    Topics: Area Under Curve; Carbapenems; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; Half-Life; Humans; Infusions, Parenteral; Male; Molecular Structure; White People

2006
Pharmacokinetics and disposition of CS-023 (RO4908463), a novel parenteral carbapenem, in animals.
    Antimicrobial agents and chemotherapy, 2007, Volume: 51, Issue:1

    Topics: Animals; Carbapenems; Chromatography, Thin Layer; Dogs; Dose-Response Relationship, Drug; Feces; Haplorhini; Male; Molecular Structure; Radioisotopes; Rats; Rats, Sprague-Dawley; Tissue Distribution

2007
Renal handling of CS-023 (RO4908463), a novel parenteral carbapenem antibiotic, in rabbits in comparison with meropenem.
    Xenobiotica; the fate of foreign compounds in biological systems, 2006, Volume: 36, Issue:12

    Topics: Animals; Carbapenems; In Vitro Techniques; Kidney; Kidney Cortex; Kidney Tubules; Male; Meropenem; Metabolic Clearance Rate; Microsomes; Models, Animal; Rabbits; Thienamycins

2006
Prediction of pharmacokinetics of CS-023 (RO4908463), a novel parenteral carbapenem antibiotic, in humans using animal data.
    Xenobiotica; the fate of foreign compounds in biological systems, 2007, Volume: 37, Issue:1

    Topics: Animals; Body Weight; Carbapenems; Humans; Infusions, Intravenous; Male; Metabolic Clearance Rate

2007
Characterization of CS-023 (RO4908463), a novel parenteral carbapenem antibiotic, and meropenem as substrates of human renal transporters.
    Drug metabolism and pharmacokinetics, 2007, Feb-25, Volume: 22, Issue:1

    Topics: Algorithms; Anti-Bacterial Agents; Biological Transport, Active; Carbapenems; Carrier Proteins; Cationic Amino Acid Transporter 2; Cell Line; Humans; Kidney; Kinetics; Meropenem; Organic Anion Transport Protein 1; Organic Anion Transporters, Sodium-Independent; Organic Cation Transporter 1; Thienamycins

2007
Pharmacodynamics of the antibacterial effect and emergence of resistance to tomopenem, formerly RO4908463/CS-023, in an in vitro pharmacokinetic model of Staphylococcus aureus infection.
    Antimicrobial agents and chemotherapy, 2008, Volume: 52, Issue:4

    Topics: Anti-Bacterial Agents; Carbapenems; Colony Count, Microbial; Drug Resistance, Bacterial; Humans; Methicillin; Methicillin Resistance; Microbial Sensitivity Tests; Staphylococcus aureus; Vancomycin

2008
Potent in vitro activity of tomopenem (CS-023) against methicillin-resistant Staphylococcus aureus and Pseudomonas aeruginosa.
    Antimicrobial agents and chemotherapy, 2008, Volume: 52, Issue:8

    Topics: Carbapenems; Imipenem; Meropenem; Methicillin Resistance; Microbial Sensitivity Tests; Pseudomonas aeruginosa; Staphylococcus aureus; Thienamycins

2008
In vivo efficacy and pharmacokinetics of tomopenem (CS-023), a novel carbapenem, against Pseudomonas aeruginosa in a murine chronic respiratory tract infection model.
    The Journal of antimicrobial chemotherapy, 2008, Volume: 62, Issue:6

    Topics: Animals; Anti-Bacterial Agents; Carbapenems; Colony Count, Microbial; Humans; Lung; Male; Meropenem; Mice; Pseudomonas aeruginosa; Pseudomonas Infections; Respiratory Tract Infections; Serum; Thienamycins

2008
Affinity of Tomopenem (CS-023) for penicillin-binding proteins in Staphylococcus aureus, Escherichia coli, and Pseudomonas aeruginosa.
    Antimicrobial agents and chemotherapy, 2009, Volume: 53, Issue:3

    Topics: Carbapenems; Escherichia coli; Microbial Sensitivity Tests; Mutation; Penicillin-Binding Proteins; Pseudomonas aeruginosa; Staphylococcus aureus

2009
In vitro postantibiotic effects of tomopenem (CS-023) against Staphylococcus aureus and Pseudomonas aeruginosa.
    Journal of medical microbiology, 2010, Volume: 59, Issue:Pt 4

    Topics: Anti-Bacterial Agents; Carbapenems; Drug Resistance, Bacterial; Methicillin-Resistant Staphylococcus aureus; Microbial Sensitivity Tests; Pseudomonas aeruginosa; Staphylococcus aureus

2010
In vivo pharmacodynamic activity of tomopenem (formerly CS-023) against Pseudomonas aeruginosa and methicillin-resistant Staphylococcus aureus in a murine thigh infection model.
    Antimicrobial agents and chemotherapy, 2010, Volume: 54, Issue:12

    Topics: Animals; Anti-Bacterial Agents; Carbapenems; Male; Methicillin-Resistant Staphylococcus aureus; Mice; Mice, Inbred ICR; Pseudomonas aeruginosa; Pseudomonas Infections; Staphylococcal Infections; Thigh

2010
Efficacy of human-simulated exposures of tomopenem (formerly CS-023) in a murine model of Pseudomonas aeruginosa and methicillin-resistant Staphylococcus aureus infection.
    Antimicrobial agents and chemotherapy, 2011, Volume: 55, Issue:11

    Topics: Animals; Carbapenems; Humans; Male; Methicillin-Resistant Staphylococcus aureus; Mice; Mice, Inbred ICR; Pseudomonas aeruginosa; Pseudomonas Infections; Staphylococcal Infections

2011