Page last updated: 2024-09-04

carbapenems and tebipenem

carbapenems has been researched along with tebipenem in 65 studies

Compound Research Comparison

Studies (carbapenems)	Trials (carbapenems)	Recent Studies (post-2010) (carbapenems)	Studies (tebipenem)	Trials (tebipenem)	Recent Studies (post-2010) (tebipenem)
7,355	147	5,277	72	8	52

Research

Studies (65)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	1 (1.54)	18.2507
2000's	14 (21.54)	29.6817
2010's	34 (52.31)	24.3611
2020's	16 (24.62)	2.80

Authors

Authors	Studies
Hikida, M; Igarashi, A; Itahashi, K; Kitamura, M; Shiba, T	1
Hasegawa, K; Kobayashi, R; Konomi, M; Morozumi, M; Sunakawa, K; Ubukata, K	1
Billal, DS; Fujihara, K; Fukushima, T; Hotomi, M; Itahashi, K; Nagura, J; Shimada, J; Suzumoto, M; Yamanaka, N; Yamauchi, K	1
Sakata, H	3
Dilay, L; Hoban, DJ; Karlowsky, JA; Noreddin, AM; Rubinstein, E; Thomson, K; Wiebe, R; Zhanel, GG	1
Ida, T; Kato, Y; Maebashi, K; Sanbongi, Y; Takahata, S	1
Baba, N; Gomi, S; Ohsawa, F; Takeuchi, Y; Watanabe, T; Yamada, M	1
Hayashi, H; Kijima, K; Koresawa, T; Kurosawa, T; Mitomi, N; Morita, J; Sato, N; Shibasaki, S; Suzuki, H; Totsuka, K	1
Doi, K; Kobayashi, T; Matsumoto, T; Muratani, T; Nakamura, T	1
Aizawa, K; Baba, S; Kasahara, H; Morita, J; Sunakawa, K	1
Aizawa, K; Morita, J; Nakashima, M; Takata, T	1
Hayashi, H; Kijima, K; Koresawa, T; Kurosawa, T; Morita, J; Sato, N; Shibasaki, S; Totsuka, K	1
Baba, S; Furukawa, M; Furuya, N; Suzuki, K; Totsuka, K; Ubukata, K; Yamanaka, N	1
Aoki, M; Hayashi, H; Kato, K; Kijima, K; Kurosawa, T; Morita, J; Shibasaki, S; Suzuki, K	1
Kurata, Y; Kurosawa, T; Nawa, T; Shibasaki, S; Suzuki, H; Yagi, Y	1
Ikeda, H; Kuroki, H; Saito, N; Tateno, N	1
Chiba, N; Ida, T; Kishii, K; Morozumi, M; Ono, A; Ubukata, K	1
Fujisaki, M; Hirakata, Y; Ikedo, M; Kaku, M; Sadamoto, S; Tateda, K; Totsuka, K; Yamaguchi, K	1
Iguchi, M; Kato, K; Kikuchi, A; Kuraoka, E; Kurosawa, T; Shibasaki, S; Shirasaka, Y; Suzuki, H; Tamai, I	1
Chiba, N; Morozumi, M; Ubukata, K	1
Sugita, R	1
Seenama, C; Thamlikitkul, V; Tiengrim, S	1
Chen, H; Li, H; Wang, H; Wang, Q; Wang, Z; Zhang, F; Zhao, C	1
Blanchard, JS; Hazra, S; Xu, H	1
Cielecka-Piontek, J; Paczkowska, M; Zalewski, P	1
Cielecka-Piontek, J; Mizera, M; Paczkowska, M; Talaczyńska, A; Zalewski, P	1
Ouchi, K; Sunakawa, K	1
Doi, N; Horita, Y; Kazumi, Y; Maeda, S	1
Miki, A; Nakamoto, N; Satoh, H; Sawada, Y; Shihyakugari, A	1
Lorchirachoonkul, N; Thamlikitkul, V; Tiengrim, S	1
Cielecka-Piontek, J; Mizera, M; Skibiński, R; Talaczyńska, A; Zalewski, P	1
Cielecka-Piontek, J; Garbacki, P; Lewandowska, K; Miklaszewski, A; Mizera, M; Skibiński, R; Talaczyńska, A; Zalewski, P	1
Cui, T; Su, M; Wang, J; Yan, H; Yang, H; Yang, Z; Yao, Q; Zhan, Y; Zhao, P	1
Kasahara, H; Kataoka, H; Matsumoto, M; Sasagawa, Y; Shimada, S	1
Iwata, S; Kuroki, H; Ouchi, K; Sakata, H; Tajima, T	1
Fisher, S; Galanis, C; Gupta, C; Kaushik, A; Lamichhane, G; Parrish, N; Story-Roller, E	1
Basta, LAB; Bianchet, MA; Kumar, P; Lamichhane, G; Lloyd, EP; Mattoo, R; Pan, YH; Saavedra, H; Townsend, CA	1
Brunelle, JL; Kaushik, A; Kumar, P; Lamichhane, G; Lloyd, EP; Mattoo, R; Townsend, CA	1
Ainsa, JA; Briffotaux, J; Buchieri, MV; Cimino, M; Gicquel, B; Hao, P; Huang, W; Liu, L; Namouchi, A; Wang, X	1
Jain, A; Parr, TR; Pucci, MJ; Utley, L; Zabawa, T	1
Jain, A; Pucci, MJ; Rubio, A	1
Ida, T; Senju, N; Sugano, T; Takata, T; Takayama, Y	1
Błaszczak, W; Cielecka-Piontek, J; Mizera, M; Paczkowska, M; Piotrowska-Kempisty, H; Siąkowska, D; Szymanowska-Powałowska, D	1
Brouillette, E; Lacasse, E; Larose, A; Malouin, F; Parr, TR; Rubio, A	1
Chen, X; Li, N; Lu, Y; Qin, Z; Ren, G; Xue, S; Yang, Z; Zhang, Y; Zhao, D	1
Adachi, Y; Iwata, S; Mokuno, E; Morozumi, M; Sakuma, M; Tajima, T; Ubukata, K	1
Dane, A; Eckburg, PB; Jain, A; Manyak, E; Melnick, D; Moore, G; Utley, L; Walpole, S	1
Cotroneo, N; Critchley, IA; Pillar, C; Pucci, MJ; Rubio, A	1
Eckburg, P; Gupta, VK; Jain, A; Lei, Y; Maier, G; Manyak, E; Melnick, D; Morelli, L	1
Cao, W; Ke, Y; Li, F; Li, L; Shi, W; Xi, P; Xu, H; Xu, X; Zhang, J	1
Cho, JC; Clark, M; Kronsberg, KA; Sodhi, V	1
Baker, S; Ballell, L; Dongol, S; Fernández Álvaro, E; Ha Thanh, T; Karkey, A; Mylona, E; Qamar, F; Qureshi, S; Voong Vinh, P; Walson, J	1
Arnold, SLM; Baker, S; Ballell Pages, L; Castañeda, P; Cortés, A; Dayao, D; de Cozar, C; de Mercado, J; Fernández Álvaro, E; García-Perez, A; Ha Thanh, T; Martínez-Martínez, MS; Martinot, A; McCloskey, M; Pavlinac, P; Price, A; Shaheen, S; Singa, B; Tran Do Hoang, N; Tzipori, S; Urones, B; Voong Vinh, P; Walson, J; Willé, DR	1
Critchley, IA; Dane, A; Eckburg, PB; Jain, A; Keutzer, T; Kwak, H; Melnick, D; Moore, G; Muir, L; Phelan, AM; Talley, AK; Walpole, S	1
Bajraktari, F; Gasink, L; Gupta, VK; Jain, A; Lei, Y; Patel, G; Srivastava, P; Talley, AK	1
Rosellen, J; Wagenlehner, F	1
Dartois, V; Dick, T; Negatu, DA; Zimmerman, MD	1
Castanheira, M; Cotroneo, N; Critchley, I; Hubler, C; Kantro, V; Kimbrough, JH; Mendes, RE	1
Asempa, TE; Fouad, A; Nicolau, DP; Quintiliani, R	1
Ambrose, PG; Bhavnani, SM; Conde, H; Cotroneo, N; Friedrich, LV; Jones, S; VanScoy, BD	1
Bhavnani, SM; Ganesan, H; Gupta, VK; Melnick, D; Rubino, CM; Safir, MC; Talley, AK	1
Bouvier, M; Le Terrier, C; Nordmann, P; Poirel, L	1
Ahmed, A; Chryssanthou, E; Davies Forsman, L; Fröberg, G	1

Reviews

4 review(s) available for carbapenems and tebipenem

Article	Year
Comparative review of the carbapenems. Drugs, 2007, Volume: 67, Issue:7 Topics: Anti-Bacterial Agents; Bacterial Infections; beta-Lactams; Carbapenems; Doripenem; Ertapenem; Humans; Imipenem; Meropenem; Thienamycins	2007
[Effect of new oral antimicrobial agents in outpatient treatment of pneumonia in children]. The Japanese journal of antibiotics, 2014, Volume: 67, Issue:3 Topics: Administration, Oral; Anti-Infective Agents; Carbapenems; Child; Fluoroquinolones; Humans; Naphthyridines; Outpatients; Pneumonia	2014
Tebipenem, the first oral carbapenem antibiotic. Expert review of anti-infective therapy, 2018, Volume: 16, Issue:7 Topics: Administration, Oral; Adult; Animals; Anti-Bacterial Agents; Carbapenems; Drug Design; Drug Resistance, Bacterial; Gram-Negative Bacteria; Gram-Negative Bacterial Infections; Humans; Prodrugs	2018
Tebipenem pivoxil hydrobromide-No PICC, no problem! Pharmacotherapy, 2021, Volume: 41, Issue:9 Topics: Anti-Infective Agents; Carbapenems; Clinical Trials, Phase III as Topic; Humans	2021

Trials

8 trial(s) available for carbapenems and tebipenem

Article	Year
Population pharmacokinetics of tebipenem pivoxil (ME1211), a novel oral carbapenem antibiotic, in pediatric patients with otolaryngological infection or pneumonia. Drug metabolism and pharmacokinetics, 2008, Volume: 23, Issue:6 Topics: Administration, Oral; Adolescent; Carbapenems; Child; Child, Preschool; Female; Humans; Infant; Male; Otorhinolaryngologic Diseases; Pneumonia, Pneumococcal; Population	2008
[Pharmacokinetics analysis of tebipenem pivoxil in a phase II clinical trial in otolaryngological infections]. The Japanese journal of antibiotics, 2009, Volume: 62, Issue:2 Topics: Adult; Bacterial Infections; Carbapenems; Dose-Response Relationship, Drug; Female; Humans; Male; Otorhinolaryngologic Diseases	2009
[Clinical efficacy, safety and PK-PD analysis of tebipenem pivoxil in a phase II clinical trial in otolaryngological infections]. The Japanese journal of antibiotics, 2009, Volume: 62, Issue:2 Topics: Administration, Oral; Adult; Aged; Bacteria; Bacterial Infections; Carbapenems; Drug Resistance, Microbial; Female; Humans; Male; Middle Aged; Otorhinolaryngologic Diseases; Treatment Outcome; Young Adult	2009
Safety, Pharmacokinetics, and Food Effect of Tebipenem Pivoxil Hydrobromide after Single and Multiple Ascending Oral Doses in Healthy Adult Subjects. Antimicrobial agents and chemotherapy, 2019, Volume: 63, Issue:9 Topics: Administration, Oral; Adult; Anti-Bacterial Agents; Carbapenems; Diarrhea; Fasting; Female; Food-Drug Interactions; Healthy Volunteers; Humans; Male; Prodrugs	2019
Randomized, Double-Blind, Placebo- and Positive-Controlled Crossover Study of the Effects of Tebipenem Pivoxil Hydrobromide on QT/QTc Intervals in Healthy Subjects. Antimicrobial agents and chemotherapy, 2021, 06-17, Volume: 65, Issue:7 Topics: Carbapenems; Cross-Over Studies; Dose-Response Relationship, Drug; Double-Blind Method; Electrocardiography; Fluoroquinolones; Healthy Volunteers; Heart Rate; Humans; Long QT Syndrome	2021
Oral Tebipenem Pivoxil Hydrobromide in Complicated Urinary Tract Infection. The New England journal of medicine, 2022, 04-07, Volume: 386, Issue:14 Topics: Administration, Intravenous; Administration, Oral; Adult; Anti-Bacterial Agents; Carbapenems; Double-Blind Method; Drug Resistance, Multiple, Bacterial; Ertapenem; Humans; Pyelonephritis; Urinary Tract Infections	2022
Bioequivalence of two oral formulations of tebipenem pivoxil hydrobromide in healthy subjects. Clinical and translational science, 2022, Volume: 15, Issue:7 Topics: Administration, Oral; Adult; Carbapenems; Healthy Volunteers; Humans; Tablets; Therapeutic Equivalency	2022
Relative bioavailability of crushed tebipenem administered through a nasogastric tube with and without enteral feeding. The Journal of antimicrobial chemotherapy, 2022, 12-23, Volume: 78, Issue:1 Topics: Administration, Oral; Area Under Curve; Biological Availability; Carbapenems; Cross-Over Studies; Enteral Nutrition; Healthy Volunteers; Humans; Tablets	2022

Other Studies

53 other study(ies) available for carbapenems and tebipenem

Article	Year
In vitro antibacterial activity of LJC 11,036, an active metabolite of L-084, a new oral carbapenem antibiotic with potent antipneumococcal activity. Antimicrobial agents and chemotherapy, 1999, Volume: 43, Issue:8 Topics: Anti-Bacterial Agents; Anti-Infective Agents; Bacterial Proteins; beta-Lactamases; beta-Lactams; Carbapenems; Carrier Proteins; Cefdinir; Cephalosporins; Dipeptidases; Drug Stability; Escherichia coli Proteins; Hexosyltransferases; Imipenem; Lactams; Levofloxacin; Microbial Sensitivity Tests; Muramoylpentapeptide Carboxypeptidase; Ofloxacin; Penicillin-Binding Proteins; Peptidoglycan Glycosyltransferase; Peptidyl Transferases; Protein Binding; Serine-Type D-Ala-D-Ala Carboxypeptidase; Thienamycins	1999
In vitro activity of tebipenem, a new oral carbapenem antibiotic, against penicillin-nonsusceptible Streptococcus pneumoniae. Antimicrobial agents and chemotherapy, 2005, Volume: 49, Issue:3 Topics: Administration, Oral; Anti-Bacterial Agents; Carbapenems; Microbial Sensitivity Tests; Penicillin Resistance; Streptococcus pneumoniae	2005
Efficacy of a novel oral carbapenem, tebipenem pivoxil (TBM-PI), against experimental otitis media caused by penicillin resistant Streptococcus pneumoniae in chinchilla. Vaccine, 2007, Mar-22, Volume: 25, Issue:13 Topics: Administration, Oral; Amoxicillin; Animals; Anti-Bacterial Agents; Carbapenems; Chinchilla; Male; Models, Animal; Otitis Media; Penicillin Resistance; Pneumococcal Infections; Streptococcus pneumoniae	2007
[Relationship between protein binding and antimicrobial activities of antibiotics against Streptococcus pneumoniae and Haemophilus influenzae]. The Japanese journal of antibiotics, 2006, Volume: 59, Issue:5 Topics: Administration, Oral; Anti-Bacterial Agents; Carbapenems; Cephalosporins; Child; Haemophilus influenzae; Humans; Injections, Intravenous; Meropenem; Microbial Sensitivity Tests; Protein Binding; Streptococcus pneumoniae; Thienamycins	2006
Comparison of the efficacies of oral beta-lactams in selection of Haemophilus influenzae transformants with mutated ftsI genes. Antimicrobial agents and chemotherapy, 2008, Volume: 52, Issue:5 Topics: Ampicillin; Bacterial Proteins; beta-Lactams; Carbapenems; Cefdinir; Cefprozil; Cephalosporins; Gene Transfer, Horizontal; Haemophilus influenzae; Mutation; Penicillin-Binding Proteins	2008
Crystal structures of biapenem and tebipenem complexed with penicillin-binding proteins 2X and 1A from Streptococcus pneumoniae. Antimicrobial agents and chemotherapy, 2008, Volume: 52, Issue:6 Topics: Anti-Bacterial Agents; Bacterial Proteins; beta-Lactams; Binding Sites; Carbapenems; Crystallization; Crystallography, X-Ray; Models, Molecular; Molecular Structure; Penicillin-Binding Proteins; Peptidyl Transferases; Protein Binding; Streptococcus pneumoniae; Thienamycins	2008
[Antimicrobial activity of tebipenem against various clinical isolates from various specimen, mainly urinary tract]. The Japanese journal of antibiotics, 2009, Volume: 62, Issue:2 Topics: Carbapenems; Citrobacter freundii; Drug Resistance, Bacterial; Enterobacter; Enterococcus faecalis; Escherichia coli; Humans; Klebsiella pneumoniae; Urinary Tract Infections	2009
[Tissue and aural discharge distribution of tebipenem pivoxil]. The Japanese journal of antibiotics, 2009, Volume: 62, Issue:2 Topics: Administration, Oral; Adult; Aged; Carbapenems; Ear, Middle; Exudates and Transudates; Hepatic Veno-Occlusive Disease; Humans; Middle Aged; Mucous Membrane; Otitis Media; Young Adult	2009
[Effect of diet on the pharmacokinetics of tebipenem pivoxil fine granules in healthy male volunteers]. The Japanese journal of antibiotics, 2009, Volume: 62, Issue:2 Topics: Adult; Carbapenems; Eating; Fasting; Humans; Intestinal Absorption; Male; Young Adult	2009
[Pharmacokinetics of tebipenem pivoxil, a novel oral carbapenem antibiotic, in experimental animals]. The Japanese journal of antibiotics, 2009, Volume: 62, Issue:3 Topics: Administration, Oral; Adolescent; Adult; Aged; Animals; Blood Proteins; Carbapenems; Cells, Cultured; Child; Child, Preschool; Cytochrome P-450 Enzyme Inhibitors; Dogs; Female; Humans; Infant; Macaca fascicularis; Male; Mice; Mice, Inbred ICR; Microsomes, Liver; Middle Aged; Protein Binding; Rats; Rats, Sprague-Dawley; Tissue Distribution; Young Adult	2009
[Convulsive liability of an oral carbapenem antibiotic, tebipenem pivoxil]. The Japanese journal of antibiotics, 2009, Volume: 62, Issue:3 Topics: Administration, Oral; Animals; Carbapenems; Cilastatin; Cilastatin, Imipenem Drug Combination; Dose-Response Relationship, Drug; Drug Combinations; Drug Synergism; Imipenem; Infusions, Intravenous; Injections, Intraventricular; Male; Mice; Pentylenetetrazole; Rats; Seizures	2009
Investigation of pneumonia-causing pathogenic organisms in children and the usefulness of tebipenem pivoxil for their treatment. Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy, 2010, Volume: 16, Issue:4 Topics: Adolescent; Carbapenems; Child; Child, Preschool; Female; Humans; Infant; Male; Microbial Sensitivity Tests; Nasopharynx; Pneumonia, Bacterial; Sputum	2010
In vitro activity of tebipenem, a new oral carbapenem antibiotic, against beta-lactamase-nonproducing, ampicillin-resistant Haemophilus influenzae. Antimicrobial agents and chemotherapy, 2010, Volume: 54, Issue:9 Topics: Ampicillin Resistance; Bacterial Proteins; beta-Lactamases; Carbapenems; Drug Resistance, Bacterial; Haemophilus influenzae; Microbial Sensitivity Tests; Polymerase Chain Reaction	2010
Development of interpretive criteria for tebipenem disk diffusion susceptibility testing with Staphylococcus spp. and Haemophilus influenzae. Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy, 2011, Volume: 17, Issue:1 Topics: Anti-Bacterial Agents; Carbapenems; Disk Diffusion Antimicrobial Tests; Haemophilus influenzae; Linear Models; Staphylococcus	2011
Intestinal absorption mechanism of tebipenem pivoxil, a novel oral carbapenem: involvement of human OATP family in apical membrane transport. Molecular pharmaceutics, 2010, Oct-04, Volume: 7, Issue:5 Topics: Administration, Oral; Animals; Anti-Bacterial Agents; Biological Transport, Active; Caco-2 Cells; Captopril; Carbapenems; Female; Humans; Hydrogen-Ion Concentration; Intestinal Absorption; Kinetics; Male; Oocytes; Organic Anion Transporters; Peptide Transporter 1; Rats; Rats, Sprague-Dawley; Symporters; Xenopus	2010
[Clinical efficacy of tebipenem pivoxil treatment in children with pneumonia, who had no relief despite having administered oral beta-lactam antibiotics]. The Japanese journal of antibiotics, 2011, Volume: 64, Issue:3 Topics: Administration, Oral; Amdinocillin Pivoxil; Anti-Bacterial Agents; beta-Lactams; Carbapenems; Child, Preschool; Drug Administration Schedule; Drug Combinations; Drug Resistance, Bacterial; Female; Haemophilus Infections; Haemophilus influenzae; Humans; Infant; Male; Pneumonia, Bacterial; Streptococcal Infections; Streptococcus pneumoniae; Treatment Failure; Treatment Outcome	2011
[Morphological changes in penicillin-resistant Streptococcus pneumoniae and beta-lactamase-nonproducing, ampicillin-resistant Haemophilus influenzae after exposure to oral antibacterial agents]. The Japanese journal of antibiotics, 2012, Volume: 65, Issue:5 Topics: Amoxicillin; Ampicillin Resistance; Anti-Bacterial Agents; Bacteriolysis; beta-Lactamases; Carbapenems; Cephalosporins; Child; Dose-Response Relationship, Drug; Fluoroquinolones; Haemophilus Infections; Haemophilus influenzae; Humans; Microscopy, Phase-Contrast; Naphthyridines; Penicillin Resistance; Pneumococcal Infections; Streptococcus pneumoniae; Time Factors	2012
Good transfer of tebipenem into middle ear effusion conduces to the favorable clinical outcomes of tebipenem pivoxil in pediatric patients with acute otitis media. Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy, 2013, Volume: 19, Issue:3 Topics: Anti-Bacterial Agents; Carbapenems; Child, Preschool; Cohort Studies; Exudates and Transudates; Female; Haemophilus Infections; Haemophilus influenzae; Humans; Infant; Male; Otitis Media with Effusion; Pneumococcal Infections; Streptococcus pneumoniae; Treatment Outcome	2013
In vitro activity of tebipenem against Burkholderia pseudomallei. International journal of antimicrobial agents, 2013, Volume: 42, Issue:4 Topics: Anti-Bacterial Agents; Burkholderia pseudomallei; Carbapenems; Humans; Microbial Sensitivity Tests	2013
In vitro antibacterial activities of two novel oral antibiotics, tebipenem and cefditoren, and other comparators against community-acquired respiratory tract infection-associated bacterial pathogens: a multicentre study in China. International journal of antimicrobial agents, 2014, Volume: 43, Issue:1 Topics: Anti-Bacterial Agents; Bacteria; Bacterial Infections; Carbapenems; Cephalosporins; China; Community-Acquired Infections; Humans; Microbial Sensitivity Tests; Respiratory Tract Infections	2014
Tebipenem, a new carbapenem antibiotic, is a slow substrate that inhibits the β-lactamase from Mycobacterium tuberculosis. Biochemistry, 2014, Jun-10, Volume: 53, Issue:22 Topics: beta-Lactamase Inhibitors; beta-Lactamases; Carbapenems; Crystallization; Crystallography, X-Ray; Mycobacterium tuberculosis; Substrate Specificity	2014
The chromatographic approach to kinetic studies of tebipenem pivoxil. Journal of chromatographic science, 2015, Volume: 53, Issue:2 Topics: Carbapenems; Chromatography, High Pressure Liquid; Drug Stability; Limit of Detection; Linear Models; Reproducibility of Results	2015
Tebipenem pivoxyl. Derivative spectroscopy study of stability of the first oral carbapenem. Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 2015, Jan-25, Volume: 135 Topics: Administration, Oral; Carbapenems; Kinetics; Reproducibility of Results; Spectrum Analysis	2015
In vitro susceptibility of Mycobacterium tuberculosis isolates to an oral carbapenem alone or in combination with β-lactamase inhibitors. Antimicrobial agents and chemotherapy, 2014, Volume: 58, Issue:11 Topics: Antitubercular Agents; beta-Lactamase Inhibitors; Carbapenems; Drug Combinations; Drug Resistance, Multiple, Bacterial; Humans; Microbial Sensitivity Tests; Mycobacterium tuberculosis; Tuberculosis, Multidrug-Resistant; Tuberculosis, Pulmonary	2014
First case report of suspected onset of convulsive seizures due to co-administration of valproic acid and tebipenem. International journal of clinical pharmacology and therapeutics, 2015, Volume: 53, Issue:1 Topics: Anti-Bacterial Agents; Anticonvulsants; Carbapenems; Child; Drug Interactions; Drug Monitoring; Humans; Male; Medication Errors; Polypharmacy; Seizures; Valproic Acid	2015
In vitro and in vivo activity of tebipenem against ESBL-producing E. coli. Journal of the Medical Association of Thailand = Chotmaihet thangphaet, 2014, Volume: 97, Issue:12 Topics: Adolescent; Adult; Anti-Bacterial Agents; beta-Lactamases; Carbapenems; Escherichia coli; Humans; In Vitro Techniques; Male; Young Adult	2014
Prediction of HPLC retention times of tebipenem pivoxyl and its degradation products in solid state by applying adaptive artificial neural network with recursive features elimination. Talanta, 2015, Volume: 137 Topics: Carbapenems; Chromatography, High Pressure Liquid; Electrical Equipment and Supplies; Models, Chemical; Neural Networks, Computer; Tandem Mass Spectrometry; Time Factors	2015
Solid-state stability studies of crystal form of tebipenem. Drug development and industrial pharmacy, 2016, Volume: 42, Issue:2 Topics: Anti-Bacterial Agents; Carbapenems; Chromatography, High Pressure Liquid; Crystallization; Drug Stability; Humidity; Kinetics; Spectrometry, Mass, Electrospray Ionization; Spectroscopy, Fourier Transform Infrared; Tandem Mass Spectrometry; Thermodynamics	2016
Antibacterial Properties of Tebipenem Pivoxil Tablet, a New Oral Carbapenem Preparation against a Variety of Pathogenic Bacteria in Vitro and in Vivo. Molecules (Basel, Switzerland), 2016, Jan-06, Volume: 21, Issue:1 Topics: Animals; Anti-Bacterial Agents; Carbapenems; Escherichia coli; Escherichia coli Infections; Female; Klebsiella Infections; Klebsiella pneumoniae; Male; Mice; Mice, Inbred ICR; Microbial Sensitivity Tests; Pseudomonas aeruginosa; Pseudomonas Infections; Sepsis; Staphylococcal Infections; Staphylococcus aureus; Survival Analysis; Tablets	2016
[Evaluation of safety and efficacy of tebipenem pivoxil granules for pediatric in pneumonia, otitis media and sinusitis]. The Japanese journal of antibiotics, 2016, Volume: 69, Issue:1 Topics: Adolescent; Anti-Bacterial Agents; Carbapenems; Child; Child, Preschool; Female; Humans; Infant; Male; Otitis Media; Pneumonia; Product Surveillance, Postmarketing; Sinusitis	2016
Pediatric community-acquired pneumonia treated with a three-day course of tebipenem pivoxil. Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy, 2017, Volume: 23, Issue:5 Topics: Adolescent; Anti-Bacterial Agents; C-Reactive Protein; Carbapenems; Child; Child, Preschool; Community-Acquired Infections; Female; Humans; Infant; Male; Pneumonia	2017
Combinations of avibactam and carbapenems exhibit enhanced potencies against drug-resistant Mycobacterium abscessus. Future microbiology, 2017, Volume: 12 Topics: Azabicyclo Compounds; beta-Lactamase Inhibitors; beta-Lactams; Carbapenems; Drug Resistance, Multiple, Bacterial; Ertapenem; Microbial Sensitivity Tests; Mycobacterium abscessus; Mycobacterium Infections, Nontuberculous; Thienamycins	2017
Structural insight into the inactivation of Mycobacterium tuberculosis non-classical transpeptidase Ldt BMC biochemistry, 2017, 05-25, Volume: 18, Issue:1 Topics: beta-Lactams; Carbapenems; Crystallography, X-Ray; Drug Design; Mycobacterium tuberculosis; Peptidyl Transferases; Protein Binding; Thienamycins	2017
Ldt Future microbiology, 2017, Volume: 12 Topics: Anti-Bacterial Agents; beta-Lactams; Carbapenems; Crystallography, X-Ray; Drug Resistance, Multiple, Bacterial; Genome, Bacterial; Mycobacterium avium Complex; Peptidyl Transferases; Sequence Analysis, DNA	2017
Ionophore A23187 shows anti-tuberculosis activity and synergy with tebipenem. Tuberculosis (Edinburgh, Scotland), 2017, Volume: 107 Topics: Antibiotics, Antitubercular; Bacterial Proteins; Calcimycin; Calcium Ionophores; Carbapenems; Cells, Cultured; Dose-Response Relationship, Drug; Drug Resistance, Bacterial; Drug Synergism; Genotype; Humans; Macrophages; Membrane Transport Proteins; Microbial Sensitivity Tests; Mutation; Mycobacterium tuberculosis	2017
Characterization of SPR994, an Orally Available Carbapenem, with Activity Comparable to Intravenously Administered Carbapenems. ACS infectious diseases, 2018, 10-12, Volume: 4, Issue:10 Topics: Administration, Intravenous; Administration, Oral; Adult; Animals; Anti-Bacterial Agents; Biological Availability; Carbapenems; Disease Models, Animal; Gastrointestinal Microbiome; Gram-Negative Bacteria; Gram-Positive Bacteria; Hospitalization; Humans; Male; Mice; Microbial Sensitivity Tests; Treatment Outcome; Urinary Tract Infections	2018
Clinical evaluation of 3-day tebipenem pivoxil therapy in children with community-acquired pneumonia. The Japanese journal of antibiotics, 2016, Volume: 69, Issue:3 Topics: Carbapenems; Child; Child, Preschool; Community-Acquired Infections; Female; Humans; Infant; Male; Pneumonia; Retrospective Studies; Time Factors	2016
Investigations on yearly changes in tebipenem susceptibility of bacterial isolates from pediatric patients -A post-marketing surveillance of tebipenem pivoxil granules for pediatric. The Japanese journal of antibiotics, 2016, Volume: 69, Issue:4 Topics: Adolescent; Anti-Bacterial Agents; Bacterial Infections; Carbapenems; Child; Child, Preschool; Genotype; Humans; Infant; Microbial Sensitivity Tests; Mutation	2016
Cyclodextrins as multifunctional excipients: Influence of inclusion into β-cyclodextrin on physicochemical and biological properties of tebipenem pivoxil. PloS one, 2019, Volume: 14, Issue:1 Topics: Anti-Bacterial Agents; beta-Cyclodextrins; Caco-2 Cells; Calorimetry, Differential Scanning; Carbapenems; Cell Membrane Permeability; Humans; Models, Theoretical; Solubility; Spectroscopy, Fourier Transform Infrared; Spectrum Analysis, Raman	2019
Antimicrobial agents and chemotherapy, 2019, Volume: 63, Issue:4 Topics: Anti-Bacterial Agents; Bacterial Proteins; beta-Lactamases; Carbapenems; Gram-Negative Bacteria; Gram-Positive Bacteria; Humans; Microbial Sensitivity Tests; Penicillin-Binding Proteins	2019
A validated UPLC-MS/MS method for determination of tebipenem in human plasma and its application to a pharmacokinetic study in healthy volunteers. Journal of pharmaceutical and biomedical analysis, 2019, Jun-05, Volume: 170 Topics: Administration, Oral; Carbapenems; Chromatography, High Pressure Liquid; Healthy Volunteers; Humans; Plasma; Reproducibility of Results; Tandem Mass Spectrometry	2019
Genetic characteristics and antibiotic resistance of Haemophilus influenzae isolates from pediatric patients with acute otitis media after introduction of 13-valent pneumococcal conjugate vaccine in Japan. Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy, 2019, Volume: 25, Issue:9 Topics: Acute Disease; Ampicillin; Anti-Bacterial Agents; beta-Lactam Resistance; Carbapenems; Cephalosporins; Child, Preschool; Drug Resistance, Multiple, Bacterial; Fluoroquinolones; Haemophilus Infections; Haemophilus influenzae; Humans; Infant; Japan; Microbial Sensitivity Tests; Multilocus Sequence Typing; Naphthyridines; Otitis Media; Pneumococcal Vaccines; Quinolones; Streptococcus pneumoniae; Vaccines, Conjugate	2019
Antimicrobial agents and chemotherapy, 2020, 07-22, Volume: 64, Issue:8 Topics: Adult; Animals; Anti-Bacterial Agents; Carbapenems; Humans; Meropenem; Mice; Urinary Tract Infections	2020
Identification of related impurities in an oral pharmaceutical formulation of tebipenem pivoxil using ultra-high-performance liquid chromatography/electrospray ionization quadrupole time-of-flight tandem mass spectrometry. Rapid communications in mass spectrometry : RCM, 2021, Aug-30, Volume: 35, Issue:16 Topics: Carbapenems; Chromatography, High Pressure Liquid; Dosage Forms; Drug Contamination; Models, Molecular; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry	2021
Tebipenem as an oral alternative for the treatment of typhoid caused by XDR Salmonella Typhi. The Journal of antimicrobial chemotherapy, 2021, 11-12, Volume: 76, Issue:12 Topics: Anti-Bacterial Agents; Carbapenems; Humans; Salmonella; Salmonella typhi; Typhoid Fever	2021
The repurposing of Tebipenem pivoxil as alternative therapy for severe gastrointestinal infections caused by extensively drug-resistant eLife, 2022, 03-15, Volume: 11 Topics: Animals; Anti-Bacterial Agents; Anti-Infective Agents; Carbapenems; Child; Communicable Diseases; Diarrhea; Drug Repositioning; Humans; Mice; Shigella; Swine	2022
[Tebipenem pivoxil : Oral carbapenem for treatment of complicated urinary tract infections]. Urologie (Heidelberg, Germany), 2022, Volume: 61, Issue:7 Topics: Carbapenems; Humans; Urinary Tract Infections	2022
Strongly Bactericidal All-Oral β-Lactam Combinations for the Treatment of Mycobacterium abscessus Lung Disease. Antimicrobial agents and chemotherapy, 2022, 09-20, Volume: 66, Issue:9 Topics: Amoxicillin; Anti-Bacterial Agents; Azabicyclo Compounds; beta-Lactamase Inhibitors; beta-Lactamases; beta-Lactams; Carbapenems; Cefuroxime; Humans; Lactams; Lung Diseases; Microbial Sensitivity Tests; Mycobacterium abscessus	2022
Antimicrobial agents and chemotherapy, 2022, 10-18, Volume: 66, Issue:10 Topics: Anti-Bacterial Agents; beta-Lactamases; Carbapenems; Escherichia coli; Escherichia coli Infections; Escherichia coli Proteins; Humans; United States; Urinary Tract Infections	2022
Evaluation of Oral Tebipenem as a Step-Down Therapy following Intravenous Ertapenem against Extended-Spectrum β-Lactamase-Producing Escherichia coli in a Hollow-Fiber Antimicrobial agents and chemotherapy, 2023, 03-16, Volume: 67, Issue:3 Topics: Anti-Bacterial Agents; beta-Lactamases; beta-Lactams; Carbapenems; Ertapenem; Escherichia coli; Humans	2023
Population Pharmacokinetic Analyses for Tebipenem after Oral Administration of Pro-Drug Tebipenem Pivoxil Hydrobromide. Antimicrobial agents and chemotherapy, 2023, 06-15, Volume: 67, Issue:6 Topics: Administration, Oral; Anti-Bacterial Agents; Carbapenems; Humans; Monobactams; Prodrugs; Pyelonephritis; Urinary Tract Infections	2023
Impact of acquired broad-spectrum β-lactamases on susceptibility to oral penems/carbapenems (tebipenem, sulopenem, and faropenem) alone or in combination with avibactam and taniborbactam β-lactamase inhibitors in Antimicrobial agents and chemotherapy, 2023, 10-18, Volume: 67, Issue:10 Topics: Anti-Bacterial Agents; Azabicyclo Compounds; beta-Lactamase Inhibitors; beta-Lactamases; Carbapenems; Escherichia coli; Meropenem; Microbial Sensitivity Tests	2023
The Antimicrobial agents and chemotherapy, 2023, 10-18, Volume: 67, Issue:10 Topics: Anti-Bacterial Agents; Azabicyclo Compounds; beta-Lactamase Inhibitors; beta-Lactamases; Carbapenems; Drug Combinations; Imipenem; Microbial Sensitivity Tests; Mycobacterium abscessus	2023