carbapenems has been researched along with ritipenem in 66 studies
| Studies (carbapenems) | Trials (carbapenems) | Recent Studies (post-2010) (carbapenems) | Studies (ritipenem) | Trials (ritipenem) | Recent Studies (post-2010) (ritipenem) |
|---|---|---|---|---|---|
| 7,355 | 147 | 5,277 | 69 | 7 | 0 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 41 (62.12) | 18.7374 |
| 1990's | 23 (34.85) | 18.2507 |
| 2000's | 2 (3.03) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Boobis, A; Davies, D; Efthymiopoulos, C; Sassella, D; Strolin Benedetti, M | 1 |
| Martín-Villacorta, J; Méndez, R; Negro, A | 1 |
| Lewis, DA; Lovering, AM; MacGowan, AP; Reeves, DS | 1 |
| Andrews, JM; Donovan, IA; Hextall, A; Wise, R | 1 |
| Battaglia, R; Fontana, E; Strolin Benedetti, M | 1 |
| Battaglia, R; Efthymiopoulos, C; Strolin Benedetti, M | 1 |
| Bergholm, AM; Dornbusch, K | 2 |
| Piddock, LJ; Traynor, EA | 1 |
| Ellis, ME; Qadri, SM; Ueno, Y | 1 |
| Livermore, DM; Wu, PJ; Yang, YJ | 1 |
| Burman, LA; Cassinelli, G; Corigli, R; Dornbusch, K; Franceschi, G; Norrby, SR; Sassella, D | 1 |
| Busnelli, V; Farina, M; Finetti, G | 1 |
| Alpegiani, M; Battistini, C; Bedeschi, A; Della Bruna, C; Franceschi, G; Perrone, E; Zarini, F | 1 |
| Castellani, P; Della Bruna, C; Jabes, D; Rossi, R; Younes, G | 1 |
| Dworkin, RJ; Kennedy, SL; Sachdeva, M; Sande, MA; Tureen, JH | 1 |
| Ballard, RC; Wise, R | 1 |
| Jabes, D; Tomasz, A | 1 |
| Giroir, AM; Grosset, J; Jarlier, V; Nicolas, MH; Philippon, A | 1 |
| Fontana, R; Tonin, EA | 1 |
| Livermore, DM; Said, AA | 1 |
| Dornbusch, K; Henning, C; Lindén, E | 1 |
| Brughera, M; Ferrari, ML; Mazué, G; Nava, A; Scampini, G | 1 |
| Lahnborg, G; Nord, CE | 1 |
| Castellani, P; Della Bruna, C; Rossi, R; Younes, G | 1 |
| Castellani, P; Della Bruna, C; Meinardi, G | 1 |
| Battaglia, R; Goldaniga, G; Montesanti, L; Strolin Benedetti, M; Vicario, G | 1 |
| Barry, AL; Jones, RN; Thornsberry, C | 1 |
| Battaglia, R; Roncucci, R; Strolin Benedetti, M; Vicario, G | 1 |
| Lewis, DA; Lovering, AM; MacGowan, AP; Pickin, DM; Reeves, DS; Routh, KR; White, LO | 1 |
| Ballard, RC; Cassinelli, G; Corigli, R; Dewland, P; Hutt, V; Lode, H; Sassella, D | 1 |
| Dornbusch, K; Göransson, E; Kronvall, G; Mörtsell, E | 2 |
| Piddock, LJ; Traynor, EA; Wise, R | 1 |
| Asad, S; Maskell, JP; Tang, T; Williams, JD | 1 |
| Benedetti, MS; Carnovali, M; Jannuzzo, MG; Mandelli, M; Moro, E; Sassella, D; Vaiani, R | 1 |
| Hoban, DJ | 1 |
| Livermore, DM; Yang, Y | 1 |
| Chin, NX; Neu, HC | 1 |
| Chin, NX; Labthavikul, P; Neu, HC | 1 |
| Lindmark, A; Nord, CE; Person, I | 1 |
| Aldridge, KE; Allen, SD; Barry, AL; Fuchs, PC; Gerlach, EH; Jones, RN; Pfaller, MA | 1 |
| Barry, AL; Jones, RN | 1 |
| Bywater, MJ; Holt, HA; Reeves, DS | 1 |
| Broholm, KA; Liljedahl, AL; Norrby, SR; Schliamser, SE | 1 |
| Schliamser, SE | 1 |
| Baskerville, AJ; Felmingham, D; Grüneberg, RN | 1 |
| Andrews, JM; Ashby, JP; Wallbridge, D; Webberley, JM; Wise, R | 1 |
| Bedeschi, A; Borghi, D; Cassinelli, G; Corigli, R; Franceschi, G; Orezzi, P; Perrone, E; Ventrella, G | 1 |
| Ernst, F; Glupczynski, Y; Grenier, P; Husson, M; Klastersky, J; Van der Auwera, P | 1 |
| Andrews, JM; Danks, G; Wise, R | 1 |
| Brughera, M; Dayan, AD; Iatropoulos, MJ; Mazue, G; Newman, AJ; Scampini, G | 1 |
| Galanakis, N; Giamarellou, H; Voutsinas, D | 1 |
| Bando, T; Chiba, S; Hiraga, Y; Hirai, Y; Inoue, H; Ito, T; Kikuchi, K; Kobayashi, H; Matsumoto, H; Moriya, K; Mouri, T; Nakashima, M; Ohmichi, M; Ohsaki, Y; Saito, A; Sakamoto, M; Sasaki, N; Shirato, K; Suda, T; Takeuchi, K; Tanifuji, Y; Tanno, Y; Tsuzino, M; Yoshida, M | 1 |
| Bischoff, W; Castellani, P; Herceg, R; Landi, V; Sassella, D | 1 |
| Abe, S; Bando, T; Hiraga, Y; Hirano, H; Inoue, H; Ito, T; Kawakami, Y; Kikuchi, K; Koba, H; Kobayashi, H; Matsumoto, H; Mouri, T; Nakashima, M; Ohmichi, M; Ohsaki, Y; Saito, A; Sakamoto, M; Shirato, K; Takahashi, M; Takeuchi, K; Tanifuji, Y; Tanno, Y; Yamaguchi, E; Yoshida, M | 1 |
| Banno, K; Maki, T; Matsuoka, M; Sato, T | 1 |
| Akama, M; Araki, H; Iyobe, S; Minami, S; Mitsuhashi, S; Narita, H; Watanabe, Y | 1 |
| Carra, L; Frigerio, E; Poggesi, I; Rimoldi, R; Sassella, D; Spinelli, R; Strolin Benedetti, M | 1 |
| Banno, K; Imado, N; Maki, T; Matsuoka, M; Sato, T | 1 |
| Endo, T; Inui, T; Matsushita, T; Oshida, T | 1 |
| Altamura, M; Arcamone, FM; Crea, A; Maggi, CA; Manzini, S; Perrotta, E; Poma, D; Salimbeni, A; Triolo, A | 1 |
| Gotoh, N; Nishino, T; Okamoto, K | 1 |
| Carnovali, M; Cassinelli, G; Corigli, R; Jannuzzo, MG; Strolin Benedetti, M; Vaiani, R | 1 |
| Frigerio, E; Hitzenberger, G; Jannuzzo, MG; Moro, E; Sassella, D; Silvestri, S; Strolin Benedetti, M | 1 |
2 review(s) available for carbapenems and ritipenem
| Article | Year |
|---|---|
Synthesis and antimicrobial spectrum of FCE 22101 and its orally available ester FCE 22891.
Topics: Anti-Bacterial Agents; Bacteria; Carbapenems; Chemical Phenomena; Chemistry; Lactams | 1989 |
Review of the in-vitro evaluation of FCE 22101.
Topics: Anti-Bacterial Agents; Bacteria; Bacterial Proteins; Carbapenems; Carrier Proteins; Hexosyltransferases; Humans; Lactams; Microbial Sensitivity Tests; Muramoylpentapeptide Carboxypeptidase; Penicillin-Binding Proteins; Peptidyl Transferases | 1989 |
7 trial(s) available for carbapenems and ritipenem
| Article | Year |
|---|---|
Intraperitoneal penetration of FCE 22101.
Topics: Aged; Ascitic Fluid; Carbapenems; Humans; Microbial Sensitivity Tests; Peritoneal Cavity | 1992 |
Pharmacokinetics in healthy subjects of FCE 22101 and its acetoxymethyl ester, FCE 22891: effect of co-administration of imipenem/cilastatin on the renal metabolism of FCE 22101.
Topics: Adult; Anti-Bacterial Agents; Carbapenems; Chromatography, High Pressure Liquid; Cilastatin; Cilastatin, Imipenem Drug Combination; Dipeptidases; Drug Combinations; Drug Interactions; Drug Therapy, Combination; Humans; Imipenem; Kidney; Lactams; Male; Reference Values | 1990 |
Pharmacokinetics of FCE 22101 in man following different modes of administration.
Topics: Adolescent; Adult; Anti-Bacterial Agents; Biological Availability; Carbapenems; Chromatography, High Pressure Liquid; Humans; Infusions, Intravenous; Injections, Intramuscular; Injections, Intravenous; Lactams; Male; Middle Aged | 1989 |
Urinary recovery and tolerability of FCE 22101 following single intravenous administration under restricted and high fluid intake.
Topics: Adult; Anti-Bacterial Agents; Carbapenems; Drinking; Humans; Hydrogen-Ion Concentration; Injections, Intravenous; Lactams; Male; Urodynamics | 1989 |
[A comparative study on the efficacies of ritipenem acoxil and cefotiam hexetil in bacterial pneumonia by the double-blind method].
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Bacteria; Carbapenems; Cefotiam; Double-Blind Method; Female; Humans; Male; Middle Aged; Pneumonia, Bacterial; Prodrugs | 1996 |
Dose finding study on the efficacy and safety of ritipenem in complicated urinary tract infections.
Topics: Adult; Aged; Aged, 80 and over; Carbapenems; Double-Blind Method; Female; Humans; Male; Middle Aged; Urinary Tract Infections | 1995 |
[Comparative study on the efficacy of ritipenem acoxil and cefotiam hexetil in chronic lower respiratory tract infections by the double-blind method].
Topics: Adult; Aged; Aged, 80 and over; Bacterial Infections; Carbapenems; Cefotiam; Cephalosporins; Chronic Disease; Double-Blind Method; Female; Humans; Japan; Male; Middle Aged; Respiratory Tract Infections | 1996 |
57 other study(ies) available for carbapenems and ritipenem
| Article | Year |
|---|---|
Pharmacokinetics of [14C]FCE 22891, a penem antibiotic, following oral administration to healthy volunteers.
Topics: Administration, Oral; Adolescent; Adult; Anti-Bacterial Agents; Carbapenems; Feces; Humans; Intestinal Absorption; Lactams; Male; Prodrugs | 1992 |
High-performance liquid chromatographic methods for the determination of the penems SCH 29482 and FCE 22101 in human serum and urine.
Topics: Anti-Bacterial Agents; Carbapenems; Chromatography, High Pressure Liquid; Chromatography, Ion Exchange; Drug Stability; Humans; Lactams; Temperature; Ultraviolet Rays | 1992 |
Pharmacokinetics and metabolism of FCE 22101 following its administration as the oral pro-drug FCE 22891.
Topics: Administration, Oral; Adult; Anti-Bacterial Agents; Carbapenems; Humans; Lactams; Male; Middle Aged; Prodrugs | 1992 |
Effect of cilastatin on the urinary metabolism of FCE 22101 in the rat.
Topics: Animals; Anti-Bacterial Agents; Carbapenems; Carbon Radioisotopes; Cilastatin; Drug Therapy, Combination; Female; Rats; Rats, Inbred Strains | 1992 |
Animal pharmacokinetics and interspecies scaling of FCE 22101, a penem antibiotic.
Topics: Animals; Carbapenems; Female; Humans; Injections, Intravenous; Macaca fascicularis; Male; Rabbits; Rats; Rats, Inbred Strains; Species Specificity | 1991 |
Synergy and cumulated killing effect of the penems FCE 22101 and FCE 25199 in combination with gentamicin against bacteria isolated from septicaemia.
Topics: Animals; Bacteria; Carbapenems; Drug Synergism; Drug Therapy, Combination; Enterococcus faecalis; Escherichia coli; Gentamicins; Klebsiella; Microbial Sensitivity Tests; Rabbits; Sepsis; Staphylococcus aureus; Streptococcus sanguis | 1991 |
Characterization of FCE 22101-resistant Enterobacteriaceae and the effect of FCE 22101 upon the activity of anti-pseudomonal beta-lactams for Pseudomonas aeruginosa.
Topics: Anti-Bacterial Agents; Carbapenems; Drug Resistance, Microbial; Enterobacteriaceae; Mutation; Pseudomonas aeruginosa | 1991 |
Antibacterial activity of FCE 22101 against relatively resistant blood culture isolates.
Topics: Anti-Bacterial Agents; Carbapenems; Drug Resistance, Microbial; Enterobacteriaceae; Humans; Imipenem; Methicillin Resistance; Saudi Arabia; Staphylococcus aureus | 1991 |
Biochemical characterization of a beta-lactamase that hydrolyzes penems and carbapenems from two Serratia marcescens isolates.
Topics: beta-Lactamase Inhibitors; beta-Lactamases; Carbapenems; Hydrolysis; Imipenem; Isoelectric Focusing; Kinetics; Microbial Sensitivity Tests; Serratia marcescens; Spectrophotometry, Ultraviolet | 1990 |
Postantibiotic effect of the penem FCE 22101 against selected gram-positive and gram-negative bacteria in vitro and in vivo by the use of a tissue cage model in rabbits.
Topics: Animals; Carbapenems; Colony Count, Microbial; Diffusion Chambers, Culture; Gram-Negative Bacteria; Gram-Positive Bacteria; Microbial Sensitivity Tests; Rabbits | 1990 |
High-performance liquid chromatographic method for the simultaneous assay of a new synthetic penem molecule and its salt-forming agent in injectable formulations.
Topics: Anti-Bacterial Agents; Arginine; Carbapenems; Chromatography, High Pressure Liquid; Dosage Forms; Injections | 1990 |
FCE 22101 and FCE 22891: in-vitro antibacterial activity at concentrations simulating human plasma levels following intravenous, intramuscular and oral administration.
Topics: Administration, Oral; Anti-Bacterial Agents; Bacteria; Carbapenems; Culture Media; Enterobacter; Escherichia coli; Humans; Injections, Intramuscular; Injections, Intravenous; Lactams; Microbial Sensitivity Tests; Models, Biological; Staphylococcus aureus; Streptococcus | 1989 |
Evaluation of FCE 22101 in experimental meningitis caused by Escherichia coli and Streptococcus pneumoniae.
Topics: Animals; Anti-Bacterial Agents; Blood Bactericidal Activity; Carbapenems; Ceftriaxone; Escherichia coli Infections; Imipenem; Meningitis; Meningitis, Pneumococcal; Microbial Sensitivity Tests; Penicillins; Rabbits | 1989 |
Lytic and bactericidal activity of FCE 22101.
Topics: Anti-Bacterial Agents; Autolysis; Bacteria; Bacterial Proteins; Carbapenems; Carrier Proteins; Escherichia coli; Hexosyltransferases; Lactams; Microbial Sensitivity Tests; Muramoylpentapeptide Carboxypeptidase; Penicillin Resistance; Penicillin-Binding Proteins; Penicillins; Peptidyl Transferases; Streptococcus pneumoniae | 1989 |
In-vitro activity of FCE 22101 and other beta-lactam antibiotics against Enterobacteriaceae resistant to third generation cephalosporins.
Topics: beta-Lactamases; Carbapenems; Cephalosporinase; Cephalosporins; Clavulanic Acid; Clavulanic Acids; Drug Resistance, Microbial; Enterobacteriaceae; Enzyme Induction; Escherichia coli; Klebsiella; Microbial Sensitivity Tests | 1989 |
Interaction of FCE 22101 with penicillin-binding proteins of Staphylococcus aureus.
Topics: Anti-Bacterial Agents; Bacterial Proteins; Carbapenems; Carrier Proteins; Hexosyltransferases; Lactams; Muramoylpentapeptide Carboxypeptidase; Penicillin-Binding Proteins; Peptidyl Transferases; Staphylococcus aureus | 1989 |
FCE 22101, a new penem antibacterial, and its oral prodrug, FCE 22891. Twenty-eighth Interscience Conference on Antimicrobial Agents and Chemotherapy. Los Angeles, California, 23-26 October 1988.
Topics: Animals; Anti-Bacterial Agents; Carbapenems; Humans; Lactams | 1989 |
In-vitro interactions of FCE 22101 with aminoglycosides against gram-negative rods.
Topics: Amikacin; Anti-Bacterial Agents; Carbapenems; Drug Interactions; Gentamicins; Gram-Negative Bacteria; Lactams; Microbial Sensitivity Tests; Tobramycin | 1989 |
In-vitro activity of the new penems FCE 22101 and FCE 24362 alone or in combination with aminoglycosides against streptococci isolated from patients with endocarditis.
Topics: Anti-Bacterial Agents; Carbapenems; Drug Synergism; Endocarditis, Bacterial; Gentamicins; Humans; Lactams; Microbial Sensitivity Tests; Netilmicin; Streptococcus; Time Factors | 1989 |
Toxicological profile of FCE 22101 and its orally available ester FCE 22891.
Topics: Animals; Anti-Bacterial Agents; Carbapenems; Female; Kidney Diseases; Lactams; Lethal Dose 50; Male; Mice; Mice, Inbred Strains; Rats; Time Factors | 1989 |
Efficacy of FCE 22101 compared with imipenem and with gentamicin plus metronidazole in the treatment of experimental intra-abdominal infections in rats.
Topics: Animals; Anti-Bacterial Agents; Bacteria; Bacterial Infections; Carbapenems; Gentamicins; Imipenem; Male; Metronidazole; Microbial Sensitivity Tests; Rats; Rats, Inbred Strains; Time Factors | 1989 |
Activity of FCE 22891 compared with cefuroxime axetil and cefixime in pulmonary and subcutaneous infections in mice.
Topics: Abscess; Animals; Anti-Bacterial Agents; Bacterial Infections; Bacteroides fragilis; Bacteroides Infections; Carbapenems; Cefixime; Cefotaxime; Cefuroxime; Cephalosporins; Female; Half-Life; Lung Diseases; Mice; Microbial Sensitivity Tests; Pneumonia, Pneumococcal | 1989 |
Activity of FCE 22101 and other beta-lactam antibiotics against experimental genital infections in the rat and mouse.
Topics: Ampicillin; Animals; Anti-Bacterial Agents; Bacterial Infections; Carbapenems; Cefuroxime; Female; Genital Diseases, Female; Mice; Rats; Surgical Wound Infection; Uterine Diseases; Uterus | 1989 |
Disposition of 14C-labelled FCE 22101 in animals.
Topics: Animals; Anti-Bacterial Agents; Autoradiography; Carbapenems; Dogs; Feces; Female; Lactams; Macaca fascicularis; Male; Rabbits; Rats; Rats, Inbred Strains; Species Specificity; Tissue Distribution | 1989 |
In-vitro activity of the penem, FCE 22101, and tentative interpretive criteria for disc susceptibility tests.
Topics: Anti-Bacterial Agents; Bacteria; Carbapenems; Drug Resistance, Microbial; Imipenem; Microbial Sensitivity Tests | 1989 |
Urinary metabolites of 14C-labelled FCE 22101 in animals.
Topics: Animals; Anti-Bacterial Agents; Biotransformation; Carbapenems; Dogs; Humans; Hydrogen-Ion Concentration; Injections, Intravenous; Lactams; Macaca fascicularis; Rabbits; Rats; Rats, Inbred Strains; Species Specificity | 1989 |
Comparative in-vitro activity of the penem FCE 22101 against recent European blood culture isolates.
Topics: Anti-Bacterial Agents; Bacteria; Carbapenems; Gram-Negative Bacteria; Humans; Methicillin; Microbial Sensitivity Tests; Penicillin Resistance; Pseudomonas; Sepsis; Staphylococcus | 1989 |
Activity of FCE 22101 against methicillin-resistant Staphylococcus aureus and affinity for penicillin binding proteins.
Topics: Anti-Bacterial Agents; Bacterial Proteins; Carbapenems; Carrier Proteins; Hexosyltransferases; Imipenem; Methicillin; Microbial Sensitivity Tests; Muramoylpentapeptide Carboxypeptidase; Penicillin Resistance; Penicillin-Binding Proteins; Peptidyl Transferases; Staphylococcus aureus | 1989 |
Comparative inhibitory and bactericidal activities of FCE 22101 against gram-positive cocci and anaerobes in vitro.
Topics: Anti-Bacterial Agents; Bacteria, Anaerobic; Bacteroides fragilis; Carbapenems; Clostridium; Culture Media; Gram-Positive Bacteria; Imipenem; Microbial Sensitivity Tests; Staphylococcus aureus; Streptococcus | 1989 |
Pharmacokinetics and tolerance of a new penem antibiotic, FCE 22101, in healthy volunteers after a single intravenous dose.
Topics: Adult; Anti-Bacterial Agents; Carbapenems; Drug Tolerance; Humans; Infusions, Intravenous; Lactams; Male; Models, Biological | 1989 |
In-vitro activity of FCE 22101 against respiratory tract pathogens with reference to production of beta-lactamases.
Topics: Anti-Bacterial Agents; Bacteria; beta-Lactamases; Carbapenems; Ceftibuten; Cephalosporins; Imipenem; Microbial Sensitivity Tests; Respiratory Tract Infections | 1989 |
In-vitro activity of a new penem FCE 22101.
Topics: Anti-Bacterial Agents; Bacteria; Bacterial Infections; beta-Lactamases; beta-Lactams; Carbapenems; Gram-Negative Bacteria; Gram-Positive Bacteria; Microbial Sensitivity Tests | 1989 |
Interactions of FCE 22101 with class I beta-lactamases.
Topics: Anti-Bacterial Agents; Bacteria; beta-Lactamases; beta-Lactams; Carbapenems; Culture Media; Enzyme Induction; Microbial Sensitivity Tests; Mutation | 1989 |
In-vitro activity of FCE 22101 and synergy studies with other antimicrobial agents.
Topics: Anti-Bacterial Agents; Bacteria; Bacterial Infections; beta-Lactamase Inhibitors; beta-Lactamases; beta-Lactams; Carbapenems; Ciprofloxacin; Drug Resistance, Microbial; Drug Synergism; Gentamicins; Gram-Positive Bacteria; Microbial Sensitivity Tests | 1989 |
The in-vitro activity of a novel penem FCE 22101 compared to other beta-lactam antibiotics.
Topics: Anti-Bacterial Agents; Bacteria; beta-Lactamase Inhibitors; beta-Lactamases; Carbapenems; Cephalosporins; Gram-Negative Bacteria; Imipenem; Microbial Sensitivity Tests; Penicillanic Acid; Thienamycins | 1985 |
Susceptibility of anaerobic bacteria to FCE 22101.
Topics: Anti-Bacterial Agents; Bacteria, Anaerobic; Carbapenems; Humans; Microbial Sensitivity Tests; Penicillanic Acid | 1987 |
In vitro activity of FCE 22101, imipenem, and ceftazidime against over 6,000 bacterial isolates and MIC quality control limits of FCE 22101.
Topics: Anti-Bacterial Agents; Bacteria; Carbapenems; Ceftazidime; Imipenem; Microbial Sensitivity Tests; Quality Control | 1988 |
In vitro interaction between the penem FCE 22101 and ceftazidime.
Topics: Anti-Bacterial Agents; beta-Lactamases; Carbapenems; Ceftazidime; Drug Interactions; Enzyme Induction; Hydrolysis; Microbial Sensitivity Tests | 1988 |
Activity of penems against methicillin-resistant Staphylococcus aureus.
Topics: Anti-Bacterial Agents; Carbapenems; Drug Resistance, Microbial; Imipenem; Lactams; Methicillin; Microbial Sensitivity Tests; Staphylococcus aureus | 1988 |
Comparative neurotoxicity of benzylpenicillin, imipenem/cilastatin and FCE 22101, a new injectible penem.
Topics: Animals; Anti-Bacterial Agents; Brain; Carbapenems; Cilastatin; Drug Interactions; Electroencephalography; Imipenem; Penicillin G; Rabbits | 1988 |
Neurotoxicity of beta-lactam antibiotics. Experimental kinetic and neurophysiological studies.
Topics: Acute Kidney Injury; Animals; Anti-Bacterial Agents; Blood-Brain Barrier; Brain; Carbapenems; Cilastatin; Drug Interactions; Electroencephalography; Enterobacteriaceae Infections; Female; Hippocampus; Imipenem; Male; Meningitis; Penicillin G; Rabbits; Rats; Rats, Inbred Strains; Seizures; Thiopental; Tissue Distribution; Uremia | 1988 |
A high performance liquid chromatography method for the determination of FCE 22101, a novel penem antimicrobial, in serum.
Topics: Anti-Bacterial Agents; Carbapenems; Chromatography, High Pressure Liquid; Humans; Lactams | 1988 |
The pharmacokinetics and tissue penetration of FCE 22101 following intravenous and oral administration.
Topics: Administration, Oral; Adult; Anti-Bacterial Agents; Blister; Carbapenems; Half-Life; Humans; Injections, Intravenous; Lactams; Male; Middle Aged; Time Factors; Tissue Distribution | 1988 |
Structure determination of the primary renal metabolite of the penem FCE 22101.
Topics: Animals; Anti-Bacterial Agents; Carbapenems; Chemical Phenomena; Chemistry; Drug Stability; Hydrolysis; Kidney; Lactams; Swine | 1988 |
In-vitro activity of two new carbapenems FCE 22101 and CGP 31608 in comparison with imipenem.
Topics: Anti-Bacterial Agents; Carbapenems; Drug Synergism; Hydrogen-Ion Concentration; Imipenem; Lactams; Microbial Sensitivity Tests; Thienamycins | 1987 |
Comparison of in vitro activity of FCE 22101, a new penem, with those of other beta-lactam antibiotics.
Topics: Anti-Bacterial Agents; Bacteria; beta-Lactamases; beta-Lactams; Carbapenems; Microbial Sensitivity Tests | 1983 |
Urinary bladder hyperplasia in the rat: non-specific pathogenetic considerations using a beta-lactam antibiotic.
Topics: Animals; Anti-Bacterial Agents; beta-Lactams; Carbapenems; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Hydrogen-Ion Concentration; Hyperplasia; Kidney; Lactams; Male; Precancerous Conditions; Rats; Time Factors; Urinary Bladder; Urinary Bladder Diseases; Urinary Bladder Neoplasms; Urine | 1994 |
The in vitro activity of FCE 22101 against gram-negative aerobic isolates resistant to third generation cephalosporins.
Topics: Carbapenems; Cephalosporins; Cross Infection; Drug Resistance, Microbial; Gram-Negative Aerobic Bacteria; Humans; Microbial Sensitivity Tests | 1994 |
Liquid chromatographic analysis of penem antibiotic FCE22101 in biological fluids with a liquid-liquid extraction procedure.
Topics: Acetates; Administration, Oral; Anti-Bacterial Agents; Calibration; Carbapenems; Chromatography, High Pressure Liquid; Humans; Lactams; Linear Models; Osmolar Concentration; Prodrugs; Reproducibility of Results; Sensitivity and Specificity; Time Factors | 1996 |
Imipenem and cephem resistant Pseudomonas aeruginosa carrying plasmids coding for class B beta-lactamase.
Topics: Anti-Infective Agents; beta-Lactam Resistance; beta-Lactamases; Carbapenems; Cephalosporinase; Hydrolysis; Imipenem; Isoelectric Focusing; Microbial Sensitivity Tests; Ofloxacin; Plasmids; Porins; Pseudomonas aeruginosa; Thienamycins | 1996 |
A study of the pharmacokinetics and tolerability of ritipenem acoxil in healthy volunteers following multiple oral dosing.
Topics: Administration, Oral; Adult; Analysis of Variance; Carbapenems; Humans; Kidney; Male; Middle Aged | 1997 |
Simultaneous determination of an active metabolite and open-ring metabolites by high performance liquid chromatography and pharmacokinetic studies of a penem antibiotic, FCE22891, in dogs.
Topics: Acetylcarnitine; Administration, Oral; Animals; Anti-Bacterial Agents; Area Under Curve; Butyrates; Carbapenems; Chromatography, High Pressure Liquid; Dogs; Formaldehyde; Hydrogen-Ion Concentration; Lactams; Prodrugs; Reproducibility of Results; Thiazoles | 1998 |
Potent bacteriolytic activity of ritipenem associated with a characteristic profile of affinities for penicillin-binding proteins of Haemophilus influenzae.
Topics: Bacterial Proteins; Bacteriolysis; Carbapenems; Carrier Proteins; Haemophilus influenzae; Hexosyltransferases; Humans; Microbial Sensitivity Tests; Muramoylpentapeptide Carboxypeptidase; Penicillin-Binding Proteins; Peptidyl Transferases | 1999 |
Synthesis and biological activity of the penem antibiotic MEN 10700 and its orally absorbed ester MEN 11505.
Topics: Administration, Oral; Animals; Anti-Bacterial Agents; Bacteria; Biological Availability; Carbapenems; Dipeptidases; Lactams; Male; Microbial Sensitivity Tests; Penicillins; Prodrugs; Rats; Rats, Sprague-Dawley; Structure-Activity Relationship | 2000 |
Pseudomonas aeruginosa reveals high intrinsic resistance to penem antibiotics: penem resistance mechanisms and their interplay.
Topics: Anti-Bacterial Agents; Bacterial Outer Membrane Proteins; Bacterial Proteins; beta-Lactam Resistance; beta-Lactamases; beta-Lactams; Biological Transport; Carbapenems; Carrier Proteins; Escherichia coli; Humans; Lactams; Membrane Transport Proteins; Microbial Sensitivity Tests; Porins; Pseudomonas aeruginosa | 2001 |
Pharmacokinetics and metabolism of FCE 22101, a new penem antibiotic.
Topics: Adult; Anti-Bacterial Agents; Carbapenems; Humans; Infusions, Intravenous; Kinetics; Male; Metabolic Clearance Rate | 1989 |
Pharmacokinetics and clinical tolerability of FCE 22101, a new penem antibiotic, in healthy volunteers after a single i.m. administration.
Topics: Adult; Anti-Bacterial Agents; Area Under Curve; Carbapenems; Humans; Injections, Intramuscular; Metabolic Clearance Rate; Reference Values | 1989 |