Page last updated: 2024-09-04

carbapenems and l 749345

carbapenems has been researched along with l 749345 in 19 studies

Compound Research Comparison

Studies (carbapenems)	Trials (carbapenems)	Recent Studies (post-2010) (carbapenems)	Studies (l 749345)	Trials (l 749345)	Recent Studies (post-2010) (l 749345)
7,355	147	5,277	19	0	0

Research

Studies (19)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	8 (42.11)	18.2507
2000's	11 (57.89)	29.6817
2010's	0 (0.00)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Gill, CJ; Hajdu, R; Kropp, H; Rosen, H; Sundelof, JG; Thompson, R	1
Han, P; Jacoby, G; Tran, J	1
Gerckens, LS; Gill, CJ; Jackson, JJ; Kropp, H; Pelak, BA; Rosen, H; Sundelof, JG; Thompson, RK	1
Cars, O; Löwdin, E; Odenholt, I	1
Birk, KL; Cairns, AM; Majumdar, AK; Musson, DG; Rogers, JD	1
Bruhin, PJ; Lin, JH; Wong, BK	1
Dorso, KL; Hammond, GG; Kohler, J; Kropp, H; Rosen, H; Silver, LL; Young, K	1
Barry, AL; Brown, SD; Fuchs, PC	2
Finegold, SM; Molitoris, D; Wexler, HM	1
Citron, DM; Goldstein, EJ; Tyrrell, KL; Vreni Merriam, C; Warren, Y	1
Bagel, S; Baquero, F; Bell, J; Carter, MW; Endtz, HP; Fernandes, CJ; Fernandes, L; Frimodt-Moller, N; Giamarellos-Bourboulis, E; Giamarellou, H; Jarlier, V; Livermore, DM; Loza, E; Mixson, L; Nguyen, J; Nonhoff, C; Nord, CE; Pfister, S; Rasmussen, LS; Shungu, DL; Struelens, MJ; Turnidge, J; van Den Braak, N; Wiedemann, B; Zbinden, R	1
Betriu, C; Gómez, M; Palau, ML; Picazo, JJ; Sánchez, A	1
Carter, MW; Livermore, DM; Oakton, KJ; Warner, M	1
Jones, RN	1
Citron, DM; Fernandez, H; Goldstein, EJ; Merriam, CV; Tyrrell, K; Warren, YA	1
Appelbaum, PC; Davies, TA; Jacobs, MR; Pankuch, GA	1
Anthony, L; Appelbaum, PC; Credito, K; Ednie, LM; Hoellman, DB; Jacobs, MR; Kelly, LM	1
Hochman, JH; Lin, JH; Ohe, T; Yamazaki, M	1

Reviews

1 review(s) available for carbapenems and l 749345

Article	Year
Evaluation of drug interactions with P-glycoprotein in drug discovery: in vitro assessment of the potential for drug-drug interactions with P-glycoprotein. Current drug metabolism, 2002, Volume: 3, Issue:3 Topics: Administration, Oral; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Assay; Biological Transport; Carbapenems; Cells, Cultured; Drug Design; Drug Interactions; In Vitro Techniques; Pharmaceutical Preparations; Species Specificity; Structure-Activity Relationship; Tissue Distribution	2002

Article

Year

Evaluation of drug interactions with P-glycoprotein in drug discovery: in vitro assessment of the potential for drug-drug interactions with P-glycoprotein.

Current drug metabolism, 2002, Volume: 3, Issue:3

Topics: Administration, Oral; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Assay; Biological Transport; Carbapenems; Cells, Cultured; Drug Design; Drug Interactions; In Vitro Techniques; Pharmaceutical Preparations; Species Specificity; Structure-Activity Relationship; Tissue Distribution

2002

Other Studies

18 other study(ies) available for carbapenems and l 749345

Article	Year
Pharmacokinetics of L-749,345, a long-acting carbapenem antibiotic, in primates. Antimicrobial agents and chemotherapy, 1997, Volume: 41, Issue:8 Topics: Animals; Carbapenems; Half-Life; Humans; Macaca mulatta; Male; Pan troglodytes; Protein Binding; Species Specificity	1997
Comparative in vitro activities of carbapenem L-749,345 and other antimicrobials against multiresistant gram-negative clinical pathogens. Antimicrobial agents and chemotherapy, 1997, Volume: 41, Issue:8 Topics: beta-Lactam Resistance; Carbapenems; Drug Resistance, Multiple; Gram-Negative Bacteria; Microbial Sensitivity Tests	1997
In vivo activity and pharmacokinetic evaluation of a novel long-acting carbapenem antibiotic, MK-826 (L-749,345). Antimicrobial agents and chemotherapy, 1998, Volume: 42, Issue:8 Topics: Animals; Bacterial Infections; Carbapenems; Female; Mice; Mice, Inbred DBA; Rats; Rats, Sprague-Dawley	1998
In vitro pharmacodynamic studies of L-749,345 in comparison with imipenem and ceftriaxone against gram-positive and gram-negative bacteria. Antimicrobial agents and chemotherapy, 1998, Volume: 42, Issue:9 Topics: Anti-Bacterial Agents; Carbapenems; Ceftriaxone; Gram-Negative Bacteria; Gram-Positive Bacteria; Imipenem; Methicillin Resistance; Microbial Sensitivity Tests	1998
High-performance liquid chromatographic methods for the determination of a new carbapenem antibiotic, L-749,345, in human plasma and urine. Journal of chromatography. B, Biomedical sciences and applications, 1998, Dec-11, Volume: 720, Issue:1-2 Topics: Anti-Infective Agents; Calibration; Carbapenems; Chromatography, High Pressure Liquid; Humans; Reference Standards; Reproducibility of Results; Spectrophotometry, Ultraviolet	1998
Dose-dependent plasma clearance of MK-826, a carbapenem antibiotic, arising from concentration-dependent plasma protein binding in rats and monkeys. Journal of pharmaceutical sciences, 1999, Volume: 88, Issue:2 Topics: Animals; Blood Proteins; Carbapenems; Chromatography, Liquid; Dose-Response Relationship, Drug; Injections, Intravenous; Macaca mulatta; Male; Protein Binding; Rats; Rats, Sprague-Dawley; Spectrophotometry, Ultraviolet	1999
In vitro activities of the potent, broad-spectrum carbapenem MK-0826 (L-749,345) against broad-spectrum beta-lactamase-and extended-spectrum beta-lactamase-producing Klebsiella pneumoniae and Escherichia coli clinical isolates. Antimicrobial agents and chemotherapy, 1999, Volume: 43, Issue:5 Topics: beta-Lactamases; Carbapenems; Cephalosporin Resistance; Escherichia coli; Klebsiella pneumoniae; Microbial Sensitivity Tests	1999
In-vitro antimicrobial activity of a carbapenem, MK-0826 (L-749,345) and provisional interpretive criteria for disc tests. The Journal of antimicrobial chemotherapy, 1999, Volume: 43, Issue:5 Topics: Bacteria, Aerobic; Bacteria, Anaerobic; Carbapenems; Enterobacteriaceae; Imipenem; Microbial Sensitivity Tests	1999
In vitro activities of MK-826 (L-749,345) against 363 strains of anaerobic bacteria. Antimicrobial agents and chemotherapy, 2000, Volume: 44, Issue:8 Topics: Anti-Bacterial Agents; Bacteria, Anaerobic; Carbapenems; Clostridium perfringens; Fusobacterium nucleatum; Humans; Microbial Sensitivity Tests; Peptostreptococcus	2000
Comparative In vitro activities of ertapenem (MK-0826) against 1,001 anaerobes isolated from human intra-abdominal infections. Antimicrobial agents and chemotherapy, 2000, Volume: 44, Issue:9 Topics: Abdominal Abscess; Bacteria, Anaerobic; Brazil; Carbapenems; Humans; Microbial Sensitivity Tests; Russia; South Africa; Spain	2000
In vitro activities of ertapenem (MK-0826) against recent clinical bacteria collected in Europe and Australia. Antimicrobial agents and chemotherapy, 2001, Volume: 45, Issue:6 Topics: Anti-Bacterial Agents; Australia; Bacteria; Carbapenems; Europe; Microbial Sensitivity Tests; Quality Control	2001
In vitro activities of ertapenem (MK-0826) against clinical bacterial isolates from 11 North American medical centers. Antimicrobial agents and chemotherapy, 2001, Volume: 45, Issue:6 Topics: Anti-Bacterial Agents; Carbapenems; Enterobacteriaceae; Gram-Positive Bacteria; Microbial Sensitivity Tests; North America	2001
In vitro activities of MK-0826 and 16 other antimicrobials against Bacteroides fragilis group strains. Antimicrobial agents and chemotherapy, 2001, Volume: 45, Issue:8 Topics: Anti-Bacterial Agents; Bacteroides fragilis; Carbapenems; Drug Resistance, Microbial; Humans; Microbial Sensitivity Tests	2001
Activity of ertapenem (MK-0826) versus Enterobacteriaceae with potent beta-lactamases. Antimicrobial agents and chemotherapy, 2001, Volume: 45, Issue:10 Topics: Bacterial Proteins; beta-Lactamases; Carbapenems; Enterobacteriaceae; Humans; Klebsiella; Microbial Sensitivity Tests; Mutation	2001
In vitro evaluation of ertapenem (MK-0826), a long-acting carbapenem, tested against selected resistant strains. Journal of chemotherapy (Florence, Italy), 2001, Volume: 13, Issue:4 Topics: Anti-Bacterial Agents; Anti-Infective Agents; Carbapenems; Ciprofloxacin; Drug Evaluation; Drug Resistance; Drug Synergism; Gentamicins; Gram-Negative Aerobic Bacteria; Gram-Positive Bacteria; Microbial Sensitivity Tests; Molecular Structure; Phenotype	2001
Comparative in vitro activity of ertapenem and 11 other antimicrobial agents against aerobic and anaerobic pathogens isolated from skin and soft tissue animal and human bite wound infections. The Journal of antimicrobial chemotherapy, 2001, Volume: 48, Issue:5 Topics: Animals; Anti-Bacterial Agents; Bacteria, Aerobic; Bacteria, Anaerobic; Bites, Human; Carbapenems; Humans; Microbial Sensitivity Tests; Skin Diseases, Bacterial; Soft Tissue Infections; Wound Infection	2001
Antipneumococcal activity of ertapenem (MK-0826) compared to those of other agents. Antimicrobial agents and chemotherapy, 2002, Volume: 46, Issue:1 Topics: Amoxicillin; Carbapenems; Humans; Microbial Sensitivity Tests; Penicillins; Streptococcus pneumoniae; Time Factors	2002
In vitro antianaerobic activity of ertapenem (MK-0826) compared to seven other compounds. Antimicrobial agents and chemotherapy, 2002, Volume: 46, Issue:1 Topics: Bacteria, Anaerobic; Carbapenems; Ceftriaxone; Cephalosporins; Humans; Imipenem; Meropenem; Microbial Sensitivity Tests; Thienamycins	2002