Page last updated: 2024-09-04

carbapenems and clavulanic acid

carbapenems has been researched along with clavulanic acid in 30 studies

Compound Research Comparison

Studies (carbapenems)	Trials (carbapenems)	Recent Studies (post-2010) (carbapenems)	Studies (clavulanic acid)	Trials (clavulanic acid)	Recent Studies (post-2010) (clavulanic acid)
7,355	147	5,277	1,801	212	424

Protein Interaction Comparison

Protein	Taxonomy	clavulanic acid (IC50)
Beta-lactamase	Klebsiella pneumoniae	1.72
Beta-lactamase	Escherichia coli	0.07
Beta-lactamase	Citrobacter gillenii	0.009
Beta-lactamase	Shouchella clausii	0.085
Beta-lactamase	Pseudomonas aeruginosa	0.1
Beta-lactamase	Pseudomonas aeruginosa	0.1
Beta-lactamase	Staphylococcus aureus	0.08
Beta-lactamase	Escherichia coli K-12	0.015
Beta-lactamase SHV-1	Escherichia coli	0.028
Beta-lactamase SHV-1	Klebsiella pneumoniae	0.17
Beta-lactamase OXA-1	Escherichia coli	3.2
Cytochrome P450 2B6	Homo sapiens (human)	0.17
Beta-lactamase	Pseudomonas aeruginosa PAO1	0.8
Beta-lactamase TEM	Escherichia coli	0.0933
Beta-lactamase	Salmonella enterica subsp. enterica serovar Westhampton	0.01
Beta-lactamase	Pseudomonas aeruginosa	0.1
Beta-lactamase	Klebsiella pneumoniae	0.02
Class D beta-lactamase	Brachyspira pilosicoli	2
Beta-lactamase	Pseudomonas luteola	0.036
Beta-lactamase	Escherichia coli	8.6
Beta-lactamase	Escherichia coli	0.009

Research

Studies (30)

Timeframe	Studies, this research(%)	All Research%
pre-1990	1 (3.33)	18.7374
1990's	4 (13.33)	18.2507
2000's	5 (16.67)	29.6817
2010's	15 (50.00)	24.3611
2020's	5 (16.67)	2.80

Authors

Authors	Studies
Giroir, AM; Grosset, J; Jarlier, V; Nicolas, MH; Philippon, A	1
Chen, HY; Livermore, DM; Yuan, M	1
Livermore, DM; Yuan, M	1
Bycroft, BW; McGowan, SJ; Porter, LE; Salmond, GP; Sebaihia, M; Stewart, GS; Williams, P	1
Blumer, JL; Bonafede, ME	1
Bellais, S; Naas, T; Nordmann, P	1
Elander, RP	1
Kong, HS; Xu, GY; Xu, XW; Yang, Q; Yu, YS; Zhong, BY	1
Jacoby, GA; Walker, VJ; Walsh, KE	1
Correia, A; Domingues, MR; Domingues, P; Fonseca, F; Henriques, I; Saavedra, MJ; Samyn, B; Sarmento, AC; van Beeumen, J	1
Bonnin, RA; Lecuyer, H; Nordmann, P; Poirel, L; Potron, A; Zahar, JR	1
Jarlier, V; Mainardi, JL; Truffot, C; Veziris, N	1
Bethel, CR; Bonnet, R; Bonomo, RA; Distler, AM; Endimiani, A; Hujer, AM; Hujer, KM; Papp-Wallace, K; Shyr, T; Taracila, M; Thomson, JM	1
Fujimoto, N; Hamasuna, R; Matsumoto, T; Mizokami, Y; Muratani, T; Sho, T	1
Antunes, NT; Frase, H; Toth, M; Vakulenko, SB; Vakulenko, V	1
Arthur, M; Dubée, V; Dubost, L; Ethève-Quelquejeu, M; Gutmann, L; Hugonnet, JE; Mainardi, JL; Marie, A; Triboulet, S	1
Arthur, M; Cordillot, M; Dubée, V; Dubost, L; Hugonnet, JE; Mainardi, JL; Marie, A; Triboulet, S	1
Dance, D	1
Bhattacharyya, RP; Hung, DT; Wivagg, CN	1
González-López, JJ; Martínez-Martínez, L	1
Abbas, S; Dortet, L; Nordmann, P; Oueslati, S; Poirel, L	1
Caminero, JA; Scardigli, A	1
Boyd, D; Carpenter, M; Desruisseau, A; Janecko, N; Mangat, CS; Martz, SL; Mulvey, MR; Reid-Smith, RJ	1
Cicek, AC; Duzgun, AO; June, CM; Leonard, DA; Sandalli, C; Saral, A	1
Chan, KF; Chen, T; He, Y; Pan, X; Zhao, Y	1
Deligios, M; Fiamma, M; Paglietti, B; Rubino, S; Sacarlal, J; Santona, A; Simbine, SE; Sumbana, JJ; Taviani, E; Zimba, T	1
Alfandari, S; Bajolet, O; Blanchard, H; Colomb-Cotinat, M; Daniau, C; Dumartin, C; Lecuru, M; Simon, L	1
Acampora, A; Albano, R; Buonsenso, D; Ferrari, V; Fiori, B; Pata, D; Sanguinetti, M; Spanu, T; Valentini, P	1
Dalğıç, D; Kandemir, T; Nağıyev, T; Üçkayabaşı, A	1
Ciszek, M; Hryniewiecka, E; Jasińska, K; Pączek, L; Wilkowski, P	1

Reviews

5 review(s) available for carbapenems and clavulanic acid

Article	Year
Role of newer broad-spectrum beta-lactam and fluoroquinolone antibiotics in children. Advances in pediatric infectious diseases, 1996, Volume: 12 Topics: Adolescent; Anti-Bacterial Agents; Anti-Infective Agents; Bacterial Infections; Carbapenems; Cephalosporins; Child; Child, Preschool; Clavulanic Acid; Clavulanic Acids; Drug Interactions; Drug Resistance, Microbial; Drug Therapy, Combination; Enzyme Inhibitors; Fluoroquinolones; Humans; Molecular Structure; Penicillanic Acid; Penicillins; Piperacillin; Tazobactam; Ticarcillin	1996
Industrial production of beta-lactam antibiotics. Applied microbiology and biotechnology, 2003, Volume: 61, Issue:5-6 Topics: Anti-Bacterial Agents; Biotechnology; Carbapenems; Cephalosporins; Cephamycins; Clavulanic Acid; Drug Industry; Fermentation; Penicillins	2003
Treatment and prophylaxis of melioidosis. International journal of antimicrobial agents, 2014, Volume: 43, Issue:4 Topics: Administration, Oral; Amoxicillin-Potassium Clavulanate Combination; Anti-Bacterial Agents; Burkholderia pseudomallei; Carbapenems; Ceftazidime; Clavulanic Acid; Drug Resistance, Multiple, Bacterial; Drug Therapy, Combination; Humans; Infusions, Parenteral; Melioidosis; Sulfamethoxazole; Trimethoprim	2014
Mechanisms of β-lactam killing and resistance in the context of Mycobacterium tuberculosis. The Journal of antibiotics, 2014, Volume: 67, Issue:9 Topics: Animals; Anti-Bacterial Agents; beta-Lactamases; beta-Lactams; Carbapenems; Clavulanic Acid; Drug Therapy, Combination; Humans; Mycobacterium tuberculosis; Tuberculosis, Multidrug-Resistant	2014
Carbapenemases in Enterobacteriaceae: types and molecular epidemiology. Enfermedades infecciosas y microbiologia clinica, 2014, Volume: 32 Suppl 4 Topics: Anti-Bacterial Agents; Bacterial Proteins; beta-Lactam Resistance; beta-Lactamases; Carbapenems; Clavulanic Acid; Drug Resistance, Multiple, Bacterial; Enterobacteriaceae; Enterobacteriaceae Infections; Genes, Bacterial; Global Health; Humans; Plasmids; Substrate Specificity; Zinc	2014

Other Studies

25 other study(ies) available for carbapenems and clavulanic acid

Article	Year
In-vitro activity of FCE 22101 and other beta-lactam antibiotics against Enterobacteriaceae resistant to third generation cephalosporins. The Journal of antimicrobial chemotherapy, 1989, Volume: 24, Issue:2 Topics: beta-Lactamases; Carbapenems; Cephalosporinase; Cephalosporins; Clavulanic Acid; Clavulanic Acids; Drug Resistance, Microbial; Enterobacteriaceae; Enzyme Induction; Escherichia coli; Klebsiella; Microbial Sensitivity Tests	1989
Mechanisms of resistance to beta-lactam antibiotics amongst Pseudomonas aeruginosa isolates collected in the UK in 1993. Journal of medical microbiology, 1995, Volume: 43, Issue:4 Topics: beta-Lactam Resistance; beta-Lactamase Inhibitors; beta-Lactamases; Carbapenems; Ceftazidime; Cephalosporins; Clavulanic Acid; Clavulanic Acids; Cloxacillin; Enzyme Inhibitors; Humans; Indicators and Reagents; Penicillin Resistance; Penicillins; Pseudomonas aeruginosa	1995
Antibiotic resistance and production of extended-spectrum beta-lactamases amongst Klebsiella spp. from intensive care units in Europe. The Journal of antimicrobial chemotherapy, 1996, Volume: 38, Issue:3 Topics: Ampicillin; Anti-Bacterial Agents; beta-Lactam Resistance; beta-Lactamase Inhibitors; beta-Lactamases; Carbapenems; Ceftazidime; Cephalosporins; Clavulanic Acid; Clavulanic Acids; Drug Therapy, Combination; Enzyme Inhibitors; Europe; Humans; Intensive Care Units; Klebsiella; Klebsiella Infections; Microbial Sensitivity Tests; Monobactams; Penicillanic Acid; Piperacillin; Tazobactam	1996
Analysis of bacterial carbapenem antibiotic production genes reveals a novel beta-lactam biosynthesis pathway. Molecular microbiology, 1996, Volume: 22, Issue:3 Topics: Amino Acid Sequence; Bacterial Proteins; Carbapenems; Chromosome Mapping; Clavulanic Acid; Clavulanic Acids; Cloning, Molecular; Cosmids; DNA, Bacterial; Escherichia coli; Gene Expression Regulation, Bacterial; Genetic Complementation Test; Molecular Sequence Data; Multigene Family; Operon; Pectobacterium carotovorum; Pheromones; Sequence Analysis, DNA; Sequence Homology, Amino Acid; Streptomyces	1996
Genetic and biochemical characterization of CGB-1, an Ambler class B carbapenem-hydrolyzing beta-lactamase from Chryseobacterium gleum. Antimicrobial agents and chemotherapy, 2002, Volume: 46, Issue:9 Topics: Amino Acid Sequence; Bacteria; Base Sequence; beta-Lactamases; Carbapenems; Clavulanic Acid; Cloning, Molecular; Conjugation, Genetic; DNA, Bacterial; DNA, Recombinant; Drug Resistance; Enzyme Induction; Enzyme Inhibitors; In Situ Hybridization; Isoelectric Focusing; Kinetics; Microbial Sensitivity Tests; Molecular Sequence Data; Plasmids	2002
Typing and characterization of carbapenem-resistant Acinetobacter calcoaceticus-baumannii complex in a Chinese hospital. Journal of medical microbiology, 2004, Volume: 53, Issue:Pt 7 Topics: Acinetobacter baumannii; Acinetobacter calcoaceticus; Acinetobacter Infections; Anti-Bacterial Agents; Bacterial Proteins; Bacterial Typing Techniques; beta-Lactam Resistance; beta-Lactamases; Carbapenems; China; Clavulanic Acid; Cloxacillin; Cross Infection; DNA Fingerprinting; DNA, Bacterial; Electrophoresis, Gel, Pulsed-Field; Enzyme Inhibitors; Genes, Bacterial; Genotype; Imipenem; Isoelectric Focusing; Isoelectric Point; Microbial Sensitivity Tests; Molecular Epidemiology; Sequence Analysis, DNA	2004
Identification of extended-spectrum, AmpC, and carbapenem- hydrolyzing beta-lactamases in Escherichia coli and Klebsiella pneumoniae by disk tests. Journal of clinical microbiology, 2006, Volume: 44, Issue:6 Topics: Anti-Bacterial Agents; Bacterial Proteins; beta-Lactam Resistance; beta-Lactamases; Carbapenems; Cefoxitin; Clavulanic Acid; Edetic Acid; Escherichia coli; Humans; Hydrolysis; Imipenem; Klebsiella pneumoniae; Microbial Sensitivity Tests	2006
Biochemical Characterization of SFC-1, a class A carbapenem-hydrolyzing beta-lactamase. Antimicrobial agents and chemotherapy, 2007, Volume: 51, Issue:12 Topics: Aztreonam; beta-Lactamases; Carbapenems; Catalysis; Cephalosporins; Clavulanic Acid; Electrophoresis, Polyacrylamide Gel; Escherichia coli; Hydrolysis; Kinetics; Molecular Weight; Penicillanic Acid; Penicillins; Recombinant Proteins; Serratia; Sulbactam; Tazobactam	2007
Carbapenem-hydrolyzing GES-type extended-spectrum beta-lactamase in Acinetobacter baumannii. Antimicrobial agents and chemotherapy, 2011, Volume: 55, Issue:1 Topics: Acinetobacter baumannii; Anti-Bacterial Agents; beta-Lactamases; Carbapenems; Clavulanic Acid; Escherichia coli; Microbial Sensitivity Tests; Models, Genetic; Molecular Sequence Data; Penicillanic Acid; Polymerase Chain Reaction; Tazobactam	2011
Activity of carbapenems combined with clavulanate against murine tuberculosis. Antimicrobial agents and chemotherapy, 2011, Volume: 55, Issue:6 Topics: Animals; Anti-Bacterial Agents; Bacterial Load; Carbapenems; Clavulanic Acid; Drug Therapy, Combination; Female; Lung; Mice; Microbial Sensitivity Tests; Spleen; Tuberculosis	2011
Exploring the inhibition of CTX-M-9 by beta-lactamase inhibitors and carbapenems. Antimicrobial agents and chemotherapy, 2011, Volume: 55, Issue:7 Topics: Anti-Bacterial Agents; beta-Lactamase Inhibitors; beta-Lactamases; Carbapenems; Clavulanic Acid; Enzyme Inhibitors; Escherichia coli Proteins; Kinetics; Meropenem; Molecular Dynamics Simulation; Molecular Structure; Penicillanic Acid; Spectrometry, Mass, Electrospray Ionization; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Sulbactam; Tazobactam; Thienamycins	2011
Mechanism of resistance of a highly carbapenem-resistant Klebsiella oxytoca isolate and comparison of susceptibility to five carbapenems. International journal of antimicrobial agents, 2012, Volume: 39, Issue:3 Topics: Aged; Anti-Bacterial Agents; Carbapenems; Clavulanic Acid; Drug Resistance, Multiple, Bacterial; Female; Humans; Klebsiella Infections; Klebsiella oxytoca; Microbial Sensitivity Tests	2012
Class A carbapenemase FPH-1 from Francisella philomiragia. Antimicrobial agents and chemotherapy, 2012, Volume: 56, Issue:6 Topics: Bacterial Proteins; beta-Lactamases; beta-Lactams; Carbapenems; Clavulanic Acid; Doripenem; Ertapenem; Escherichia coli; Francisella; Imipenem; Meropenem; Microbial Sensitivity Tests; Penicillanic Acid; Sulbactam; Tazobactam; Thienamycins	2012
Inactivation of Mycobacterium tuberculosis l,d-transpeptidase LdtMt₁ by carbapenems and cephalosporins. Antimicrobial agents and chemotherapy, 2012, Volume: 56, Issue:8 Topics: Anti-Bacterial Agents; Carbapenems; Cephalosporins; Clavulanic Acid; Extensively Drug-Resistant Tuberculosis; Meropenem; Microbial Sensitivity Tests; Mycobacterium tuberculosis; Peptidoglycan; Peptidyl Transferases; Thienamycins	2012
In vitro cross-linking of Mycobacterium tuberculosis peptidoglycan by L,D-transpeptidases and inactivation of these enzymes by carbapenems. Antimicrobial agents and chemotherapy, 2013, Volume: 57, Issue:12 Topics: Antitubercular Agents; Bacterial Proteins; beta-Lactamase Inhibitors; beta-Lactamases; beta-Lactams; Carbapenems; Cell Wall; Clavulanic Acid; Doripenem; Enzyme Assays; Ertapenem; Escherichia coli; Gene Expression; Imipenem; Kinetics; Meropenem; Mycobacterium tuberculosis; Peptidoglycan; Peptidyl Transferases; Recombinant Proteins; Thienamycins	2013
Genetic and Biochemical Characterization of FRI-1, a Carbapenem-Hydrolyzing Class A β-Lactamase from Enterobacter cloacae. Antimicrobial agents and chemotherapy, 2015, Volume: 59, Issue:12 Topics: Amino Acid Sequence; Anti-Bacterial Agents; Bacterial Proteins; beta-Lactamase Inhibitors; beta-Lactamases; Carbapenems; Clavulanic Acid; Cloning, Molecular; Drug Resistance, Multiple, Bacterial; Enterobacter cloacae; Humans; Inhibitory Concentration 50; Microbial Sensitivity Tests; Molecular Sequence Data; Penicillanic Acid; Plasmids; Sequence Homology, Amino Acid; Tazobactam	2015
Classification of antituberculosis drugs: a new proposal based on the most recent evidence. The European respiratory journal, 2015, Volume: 46, Issue:4 Topics: Antitubercular Agents; Carbapenems; Clavulanic Acid; Clofazimine; Diarylquinolines; Drug Therapy, Combination; Extensively Drug-Resistant Tuberculosis; Humans; Infectious Disease Medicine; Linezolid; Nitroimidazoles; Oxazoles; Practice Guidelines as Topic; Tuberculosis, Multidrug-Resistant; World Health Organization	2015
Characterization of VCC-1, a Novel Ambler Class A Carbapenemase from Vibrio cholerae Isolated from Imported Retail Shrimp Sold in Canada. Antimicrobial agents and chemotherapy, 2016, Jan-11, Volume: 60, Issue:3 Topics: Amino Acid Sequence; Animals; Aztreonam; Bacterial Proteins; Base Sequence; beta-Lactamases; Canada; Carbapenems; Cephalosporins; Clavulanic Acid; Drug Resistance, Multiple, Bacterial; Genome, Bacterial; Humans; Microbial Sensitivity Tests; Penaeidae; Penicillanic Acid; Penicillins; Seafood; Sequence Alignment; Sequence Analysis, DNA; Tazobactam; Vibrio cholerae	2016
Kinetic characterization of GES-22 β-lactamase harboring the M169L clinical mutation. The Journal of antibiotics, 2016, Volume: 69, Issue:12 Topics: Acinetobacter baumannii; Amino Acid Sequence; Amino Acid Substitution; Anti-Bacterial Agents; Aztreonam; beta-Lactamase Inhibitors; beta-Lactamases; Carbapenems; Ceftazidime; Cephalosporins; Clavulanic Acid; Drug Resistance, Bacterial; Hydrolysis; Mutation; Penicillins; Plasmids; Protein Conformation; Substrate Specificity; Turkey	2016
Modified Penicillin Molecule with Carbapenem-Like Stereochemistry Specifically Inhibits Class C β-Lactamases. Antimicrobial agents and chemotherapy, 2017, Volume: 61, Issue:12 Topics: beta-Lactamase Inhibitors; beta-Lactamases; Binding Sites; Carbapenem-Resistant Enterobacteriaceae; Carbapenems; Catalytic Domain; Cephalosporins; Clavulanic Acid; Crystallography, X-Ray; Models, Molecular; Molecular Structure; Penicillins; Stereoisomerism; Sulbenicillin	2017
High-risk lineages among extended-spectrum β-lactamase-producing Escherichia coli from extraintestinal infections in Maputo Central Hospital, Mozambique. International journal of antimicrobial agents, 2022, Volume: 60, Issue:4 Topics: Amoxicillin; Anti-Bacterial Agents; beta-Lactamases; Carbapenems; Cefotaxime; Ceftazidime; Ciprofloxacin; Clavulanic Acid; Escherichia coli; Escherichia coli Infections; Escherichia coli Proteins; Extraintestinal Pathogenic Escherichia coli; Gentamicins; Hospitals; Humans; Iron; Mozambique; Piperacillin; Tazobactam; Trimethoprim, Sulfamethoxazole Drug Combination	2022
Evolution of antibiotic treatments for healthcare-associated infections caused by extended-spectrum beta-lactamase-producing Enterobacteriaceae in France. Infectious diseases now, 2022, Volume: 52, Issue:7 Topics: Aminoglycosides; Amoxicillin; Anti-Bacterial Agents; beta-Lactamases; beta-Lactams; Carbapenems; Clavulanic Acid; Cross Infection; Delivery of Health Care; Enterobacteriaceae; Enterobacteriaceae Infections; France; Humans; Nitrofurantoin; Ofloxacin; Penicillins; Urinary Tract Infections	2022
Escherichia coli resistance patterns, empiric and targeted antibiotic prescriptions in children: a single center experience. Acta bio-medica : Atenei Parmensis, 2022, 10-26, Volume: 93, Issue:5 Topics: Aminoglycosides; Anti-Bacterial Agents; Carbapenems; Cephalosporins; Child; Clavulanic Acid; Escherichia coli; Escherichia coli Infections; Humans; Infant; Microbial Sensitivity Tests; Prescriptions; Retrospective Studies	2022
[Relationship of Hypervirulent Capsular Genotypes of Klebsiella pneumoniae with Antibiotic Susceptibility and Beta-Lactamase Genes]. Mikrobiyoloji bulteni, 2023, Volume: 57, Issue:1 Topics: Amoxicillin; Anti-Bacterial Agents; beta-Lactamases; Carbapenems; Clavulanic Acid; Colistin; Drug Resistance, Bacterial; Genotype; Klebsiella pneumoniae; Microbial Sensitivity Tests; Piperacillin; Tazobactam	2023
Breaking Antimicrobial Resistance: High-Dose Amoxicillin with Clavulanic Acid for Urinary Tract Infections Due to Extended-Spectrum Beta-Lactamase (ESBL)-Producing Klebsiella pneumoniae. Annals of transplantation, 2023, May-16, Volume: 28 Topics: Amoxicillin; Anti-Bacterial Agents; beta-Lactamases; Carbapenems; Clavulanic Acid; Drug Resistance, Bacterial; Humans; Klebsiella Infections; Klebsiella pneumoniae; Microbial Sensitivity Tests; Urinary Tract Infections	2023