Page last updated: 2024-09-04

carbapenems and cilastatin

carbapenems has been researched along with cilastatin in 49 studies

Compound Research Comparison

Studies (carbapenems)	Trials (carbapenems)	Recent Studies (post-2010) (carbapenems)	Studies (cilastatin)	Trials (cilastatin)	Recent Studies (post-2010) (cilastatin)
7,355	147	5,277	999	270	137

Research

Studies (49)

Timeframe	Studies, this research(%)	All Research%
pre-1990	3 (6.12)	18.7374
1990's	16 (32.65)	18.2507
2000's	15 (30.61)	29.6817
2010's	14 (28.57)	24.3611
2020's	1 (2.04)	2.80

Authors

Authors	Studies
Battaglia, R; Fontana, E; Strolin Benedetti, M	1
Jacobus, NV; Petersen, PJ; Testa, RT; Weiss, WJ	1
Burman, LA; Cassinelli, G; Corigli, R; Dornbusch, K; Franceschi, G; Norrby, SR; Sassella, D	1
Giles, RE; Patel, JB	1
Broholm, KA; Liljedahl, AL; Norrby, SR; Schliamser, SE	1
Schliamser, SE	1
Fanta, J; Felbr, O; Lochmann, O; Pelák, Z; Vyhnánek, F	1
Brismar, B; Eklund, AE; Nord, CE	1
Cravarezza, P; Romanelli, G	1
Diwok, K; Hamacher, J; Kohl, FV; Lichey, J; Lode, H; Vogel, F; Wendel, H	1
Geroulanos, SJ	1
Baldassarre, R; Comunale, L; Poletti, G; Tallarigo, C	1
Cama, L; Kropp, H; Sasor, MW; Sundelof, JG; Thompson, R; White, KM	1
Norrby, SR	1
Endo, R; Hisaoka, M; Kawamoto, I; Miyauchi, M; Yasuda, H	1
Blanquer, J; Cobo, L; Corcia, S; Daguerre, M; de Latorre, FJ; Del Nogal, F; Garau, J; León, C; Net, A; Rello, J	1
Domon, H; Furuya, N; Ishii, K; Matsumoto, T; Miyazaki, S; Ohno, A; Tateda, K; Yamaguchi, K	1
Ambrose, PG; Nightingale, CH; Quintiliani, R; Richerson, MA	1
Kim, SH; Kim, WB; Kwon, JW; Lee, MG	1
Pietroski, N; Schlossberg, D	1
Giller, RH; Nelson, WK; Quinones, R; Rayback, PA	1
Cravarezza, P; Donati, P; Franchino, L; Grassi, V; Pozzi, A; Prometti, P; Ravizzola, G; Romanelli, G; Zulli, R	1
Mikamo, H; Ninomiya, M; Tamaya, T	1
Araake, M; Hara, T; Watabe, H	1
Inoue, M; Kaku, M; Nasu, M; Sagawa, K; Yokoyama, T	1
Axtell, SS; Callahan, J; Shekar, R; Sodhi, M	1
Brink, AJ; Feldman, C; Grolman, DC; Muckart, D; Pretorius, J; Richards, GA; Senekal, M; Sieling, W	1
Donskey, CJ; Pultz, NJ; Stiefel, U	1
Archontoulis, N; Giamarellos-Bourboulis, EJ; Giamarellou, H; Mega, A; Pavleas, I; Rigas, K; Thomopoulos, G; Vernikos, P	1
Ha, JR; Kim, HG; Kim, J; Kim, JG; Lee, DG; Lee, JM; Lee, SH; Oh, SW	1
Gfröer, S; Knabbe, C; Rahmig, H; Schroeppel, K; Susa, M; Weile, J	1
Katsube, T; Yamano, Y; Yano, Y	1
Ha, JR; Kim, BO; Kim, HG; Kim, JG; Kim, JM; Lee, DG; Lee, JM; Lee, SH; Oh, SW	1
Kurata, Y; Kurosawa, T; Nawa, T; Shibasaki, S; Suzuki, H; Yagi, Y	1
Chen, J; Mody, SH; Shorr, AF; Zilberberg, MD	1
Bonomo, RA; Endimiani, A; Papp-Wallace, KM; Taracila, MA	1
Chen, CC; Chen, CH; Chiang, SR; Chuang, YC; Ko, WC; Lee, NY; Shieh, JM; Tang, HJ	1
Badal, RE; Boffard, KD; Botha, RF; Brink, AJ; Feldman, C; Grolman, DC; Joubert, I; Poswa, X; Pretorius, J; Richards, GA; Senekal, M; Veller, M	1
Chastre, J; Cirillo, I; Clavel, M; Kaniga, K; Kimko, H; Kollef, MH; Michiels, B; Redman, R; Restrepo, MI	1
Martin-Loeches, I; Torres, A	1
Kurtinecz, M; Li, G; Mitrani-Gold, FS; Mundy, LM; Singh, KP; Tomayko, JF; Wetherington, J	1
Cannon, JP; Clark, NM; Grim, SA; Lee, TA; Setlak, P	1
Igarashi, Y; Inui, K; Ohara, H; Ryozawa, S; Tazuma, S; Tsuyuguchi, T	1
Decosterd, LA; Eggimann, P; Fournier, A; Marchetti, O; Pagani, JL; Pannatier, A; Que, YA; Revelly, JP; Voirol, P	1
Aydın, F; Bayramoğlu, G; Gençoğlu Özgür, Ç; Kılıç, AO; Uluçam, G	1
Chanawong, A; Charoensri, N; Lulitanond, A; Piyapatthanakul, S; Srisrattakarn, A; Supajeen, A; Wilailuckana, C; Wonglakorn, L	1
Boudawara, T; Daoud, S; Kallel, R; Ksouda, K; Sahnoun, Z; Tahri, A; Zeghal, KM	1
Chahine, EB; Karaoui, LR; Mansour, H; Ouweini, AEL	1

Reviews

6 review(s) available for carbapenems and cilastatin

Article	Year
[Multicenter comparative study of meropenem vs. imipenem in the intramuscular treatment of hospital infections of the urinary tract]. Minerva urologica e nefrologica = The Italian journal of urology and nephrology, 1995, Volume: 47, Issue:3 Topics: Adult; Aged; Carbapenems; Chi-Square Distribution; Cilastatin; Cross Infection; Female; Humans; Imipenem; Male; Meropenem; Middle Aged; Protease Inhibitors; Thienamycins; Urinary Tract Infections	1995
Neurotoxicity of carbapenem antibacterials. Drug safety, 1996, Volume: 15, Issue:2 Topics: Animals; Carbapenems; Child; Cilastatin; Humans; Imipenem; Meropenem; Receptors, GABA; Seizures; Thienamycins	1996
Appropriate use of the carbapenems. South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde, 2004, Volume: 94, Issue:10 Pt 2 Topics: Anti-Bacterial Agents; Bacterial Infections; beta-Lactams; Carbapenems; Cilastatin; Community-Acquired Infections; Cross Infection; Drug Resistance, Bacterial; Drug Utilization; Ertapenem; Humans; Imipenem; Lactams; Meropenem; Patient Selection; Pneumonia, Bacterial; Practice Patterns, Physicians'; Protease Inhibitors; South Africa; Surgical Wound Infection; Thienamycins; Urinary Tract Infections	2004
Carbapenems: past, present, and future. Antimicrobial agents and chemotherapy, 2011, Volume: 55, Issue:11 Topics: Anti-Bacterial Agents; beta-Alanine; beta-Lactams; Carbapenems; Cilastatin; Cilastatin, Imipenem Drug Combination; Doripenem; Drug Combinations; Ertapenem; Humans; Imipenem; Thienamycins	2011
Systematic review and meta-analysis of antimicrobial treatment effect estimation in complicated urinary tract infection. Antimicrobial agents and chemotherapy, 2013, Volume: 57, Issue:11 Topics: Anti-Bacterial Agents; Carbapenems; Cilastatin; Cilastatin, Imipenem Drug Combination; Clinical Trials as Topic; Databases, Bibliographic; Doripenem; Drug Combinations; Female; Humans; Imipenem; Levofloxacin; Male; Research Design; Treatment Outcome; Urinary Tract Infections	2013
The risk of seizures among the carbapenems: a meta-analysis. The Journal of antimicrobial chemotherapy, 2014, Volume: 69, Issue:8 Topics: Adult; Anti-Bacterial Agents; beta-Lactams; Carbapenems; Child; Cilastatin; Cilastatin, Imipenem Drug Combination; Doripenem; Drug Combinations; Ertapenem; Humans; Imipenem; Meropenem; Risk; Seizures; Thienamycins	2014

Trials

13 trial(s) available for carbapenems and cilastatin

Article	Year
Pharmacokinetics in healthy subjects of FCE 22101 and its acetoxymethyl ester, FCE 22891: effect of co-administration of imipenem/cilastatin on the renal metabolism of FCE 22101. The Journal of antimicrobial chemotherapy, 1990, Volume: 25, Issue:3 Topics: Adult; Anti-Bacterial Agents; Carbapenems; Chromatography, High Pressure Liquid; Cilastatin; Cilastatin, Imipenem Drug Combination; Dipeptidases; Drug Combinations; Drug Interactions; Drug Therapy, Combination; Humans; Imipenem; Kidney; Lactams; Male; Reference Values	1990
Immune response in patients with intra-abdominal infections treated with carbapenems. International journal of clinical pharmacology research, 1994, Volume: 14, Issue:3 Topics: Abdominal Abscess; Adolescent; Adult; Aged; Antibodies, Bacterial; Bacteria, Aerobic; Bacteria, Anaerobic; Carbapenems; Cilastatin; Fluorescent Antibody Technique; Humans; Imipenem; Injections, Intravenous; Meropenem; Middle Aged; Thienamycins	1994
Intramuscular meropenem in the treatment of bacterial infections of the urinary and lower respiratory tracts. Italian Intramuscular Meropenem Study Group. The Journal of antimicrobial chemotherapy, 1995, Volume: 36 Suppl A Topics: Bacterial Infections; Carbapenems; Ceftazidime; Cilastatin; Humans; Imipenem; Injections, Intramuscular; Meropenem; Respiratory Tract Infections; Thienamycins; Treatment Outcome; Urinary Tract Infections	1995
Treatment of acute bacterial exacerbations of chronic obstructive pulmonary disease in hospitalised patients--a comparison of meropenem and imipenem/cilastatin. COPD Study Group. The Journal of antimicrobial chemotherapy, 1995, Volume: 36 Suppl A Topics: Bacterial Infections; Bronchitis; Carbapenems; Cilastatin; Drug Therapy, Combination; Drug Tolerance; Hospitalization; Humans; Imipenem; Lung Diseases, Obstructive; Meropenem; Prospective Studies; Thienamycins; Treatment Outcome	1995
Meropenem versus imipenem/cilastatin in intra-abdominal infections requiring surgery. Meropenem Study Group. The Journal of antimicrobial chemotherapy, 1995, Volume: 36 Suppl A Topics: Abdomen; Adolescent; Adult; Aged; Bacterial Infections; Carbapenems; Cilastatin; Drug Therapy, Combination; Humans; Imipenem; Injections, Intravenous; Meropenem; Middle Aged; Thienamycins; Treatment Outcome	1995
[Multicenter comparative study of meropenem vs. imipenem in the intramuscular treatment of hospital infections of the urinary tract]. Minerva urologica e nefrologica = The Italian journal of urology and nephrology, 1995, Volume: 47, Issue:3 Topics: Adult; Aged; Carbapenems; Chi-Square Distribution; Cilastatin; Cross Infection; Female; Humans; Imipenem; Male; Meropenem; Middle Aged; Protease Inhibitors; Thienamycins; Urinary Tract Infections	1995
Prospective, randomised, multicentre study of meropenem versus imipenem/cilastatin as empiric monotherapy in severe nosocomial infections. European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology, 1997, Volume: 16, Issue:11 Topics: Adolescent; Adult; Aged; Aged, 80 and over; Carbapenems; Cilastatin; Cilastatin, Imipenem Drug Combination; Cross Infection; Drug Combinations; Drug Therapy, Combination; Female; Humans; Imipenem; Male; Meropenem; Middle Aged; Prospective Studies; Thienamycins	1997
Empiric carbapenem monotherapy in pediatric bone marrow transplant recipients. The Annals of pharmacotherapy, 2002, Volume: 36, Issue:9 Topics: Adolescent; Bacterial Infections; Bone Marrow Transplantation; Carbapenems; Child; Child, Preschool; Cilastatin; Drug Costs; Female; Humans; Imipenem; Male; Meropenem; Postoperative Complications; Prospective Studies; Protease Inhibitors; Thienamycins; Vomiting	2002
Carbapenems in the treatment of severe community-acquired pneumonia in hospitalized elderly patients: a comparative study against standard therapy. Journal of chemotherapy (Florence, Italy), 2002, Volume: 14, Issue:6 Topics: Aged; Aged, 80 and over; Anti-Bacterial Agents; Carbapenems; Ceftriaxone; Cilastatin; Cilastatin, Imipenem Drug Combination; Clarithromycin; Community-Acquired Infections; Costs and Cost Analysis; Drug Combinations; Drug Costs; Drug Therapy, Combination; Female; Hospitalization; Humans; Imipenem; Male; Meropenem; Pneumonia, Bacterial; Prospective Studies; Thienamycins; Treatment Outcome	2002
[Investigation on administration method of carbapenems]. The Japanese journal of antibiotics, 2002, Volume: 55, Issue:6 Topics: Adult; Aged; beta-Alanine; Body Temperature; C-Reactive Protein; Carbapenems; Cilastatin; Cilastatin, Imipenem Drug Combination; Drug Administration Schedule; Drug Combinations; Female; Humans; Imipenem; Leukocyte Count; Meropenem; Middle Aged; Parametritis; Thienamycins	2002
Impact of carbapenem administration on systemic endotoxemia in patients with severe sepsis and Gram-negative bacteremia. Journal of chemotherapy (Florence, Italy), 2006, Volume: 18, Issue:5 Topics: Aged; Aged, 80 and over; Anti-Bacterial Agents; Bacteremia; C-Reactive Protein; Carbapenems; Cilastatin; Cilastatin, Imipenem Drug Combination; Drug Combinations; Endotoxemia; Female; Gram-Negative Bacterial Infections; Humans; Imipenem; Interleukin-6; Lipopolysaccharides; Male; Middle Aged; Pneumonia, Ventilator-Associated; Sepsis	2006
A randomized trial of 7-day doripenem versus 10-day imipenem-cilastatin for ventilator-associated pneumonia. Critical care (London, England), 2012, Nov-13, Volume: 16, Issue:6 Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anti-Bacterial Agents; Carbapenems; Cilastatin; Doripenem; Double-Blind Method; Drug Administration Schedule; Drug Therapy, Combination; Female; Humans; Imipenem; Infusions, Intravenous; Male; Middle Aged; Pneumonia, Ventilator-Associated; Young Adult	2012
Clinical efficacy of intravenous doripenem in patients with acute biliary tract infection: a multicenter, randomized, controlled trial with imipenem/cilastatin as comparator. Journal of gastroenterology, 2015, Volume: 50, Issue:2 Topics: Acute Disease; Adult; Aged; Aged, 80 and over; Anti-Bacterial Agents; Bacterial Infections; Body Temperature; C-Reactive Protein; Carbapenems; Cholangitis; Cholecystitis, Acute; Cilastatin; Cilastatin, Imipenem Drug Combination; Doripenem; Drug Combinations; Female; Humans; Imipenem; Infusions, Intravenous; Male; Middle Aged; Treatment Outcome; Young Adult	2015

Other Studies

31 other study(ies) available for carbapenems and cilastatin

Article	Year
Effect of cilastatin on the urinary metabolism of FCE 22101 in the rat. The Journal of antimicrobial chemotherapy, 1992, Volume: 29, Issue:1 Topics: Animals; Anti-Bacterial Agents; Carbapenems; Carbon Radioisotopes; Cilastatin; Drug Therapy, Combination; Female; Rats; Rats, Inbred Strains	1992
In vitro and in vivo activities of LJC10,627, a new carbapenem with stability to dehydropeptidase I. Antimicrobial agents and chemotherapy, 1991, Volume: 35, Issue:1 Topics: Amikacin; Animals; Bacterial Infections; Bacteroides fragilis; Carbapenems; Ceftazidime; Cilastatin; Ciprofloxacin; Dipeptidases; Drug Therapy, Combination; Escherichia coli; Female; Imipenem; Klebsiella pneumoniae; Metronidazole; Mice; Microbial Sensitivity Tests; Piperacillin; Pseudomonas aeruginosa; Staphylococcus; Streptococcus; Thienamycins	1991
Meropenem: evidence of lack of proconvulsive tendency in mice. The Journal of antimicrobial chemotherapy, 1989, Volume: 24 Suppl A Topics: Animals; Carbapenems; Cilastatin; Imipenem; Male; Meropenem; Mice; Seizures; Thienamycins	1989
Comparative neurotoxicity of benzylpenicillin, imipenem/cilastatin and FCE 22101, a new injectible penem. The Journal of antimicrobial chemotherapy, 1988, Volume: 22, Issue:5 Topics: Animals; Anti-Bacterial Agents; Brain; Carbapenems; Cilastatin; Drug Interactions; Electroencephalography; Imipenem; Penicillin G; Rabbits	1988
Neurotoxicity of beta-lactam antibiotics. Experimental kinetic and neurophysiological studies. Scandinavian journal of infectious diseases. Supplementum, 1988, Volume: 55 Topics: Acute Kidney Injury; Animals; Anti-Bacterial Agents; Blood-Brain Barrier; Brain; Carbapenems; Cilastatin; Drug Interactions; Electroencephalography; Enterobacteriaceae Infections; Female; Hippocampus; Imipenem; Male; Meningitis; Penicillin G; Rabbits; Rats; Rats, Inbred Strains; Seizures; Thiopental; Tissue Distribution; Uremia	1988
[New approaches in the use of antibiotics in the treatment of postoperative intra-abdominal infections]. Rozhledy v chirurgii : mesicnik Ceskoslovenske chirurgicke spolecnosti, 1995, Volume: 74, Issue:3 Topics: Abdomen; Adolescent; Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Bacterial Infections; Carbapenems; Cilastatin; Cilastatin, Imipenem Drug Combination; Drug Combinations; Female; Humans; Imipenem; Male; Middle Aged; Postoperative Complications	1995
Pharmacokinetics in nonhuman primates of a prototype carbapenem active against methicillin-resistant Staphylococcus aureus. Antimicrobial agents and chemotherapy, 1996, Volume: 40, Issue:3 Topics: Animals; Anti-Bacterial Agents; Carbapenems; Cilastatin; Cilastatin, Imipenem Drug Combination; Dipeptidases; Drug Combinations; Drug Therapy, Combination; Half-Life; Imidazoles; Imipenem; Injections, Intravenous; Kidney; Macaca mulatta; Male; Methicillin Resistance; Pan troglodytes; Staphylococcus aureus	1996
Synthesis and structure-activity relationships of a novel oral carbapenem, CS-834. The Journal of antibiotics, 1997, Volume: 50, Issue:5 Topics: Administration, Oral; Animals; Carbapenems; Cilastatin; Dogs; Drug Interactions; Gram-Positive Bacteria; Injections, Intravenous; Mice; Microbial Sensitivity Tests; Protease Inhibitors; Structure-Activity Relationship	1997
In vitro and in vivo antibacterial activities of CS-834, a new oral carbapenem. Antimicrobial agents and chemotherapy, 1998, Volume: 42, Issue:3 Topics: Animals; Carbapenems; Cilastatin; Drug Resistance, Microbial; Gram-Negative Bacteria; Gram-Negative Bacterial Infections; Gram-Positive Bacteria; Gram-Positive Bacterial Infections; Humans; Male; Mice; Mice, Inbred ICR; Microbial Sensitivity Tests; Prodrugs; Protease Inhibitors; Sepsis	1998
Formulary review of the carbapenems: comparison of imipenem/cilastatin and meropenem. Connecticut medicine, 1998, Volume: 62, Issue:3 Topics: Carbapenems; Cilastatin; Drug Combinations; Drug Costs; Humans; Imipenem; Meropenem; Microbial Sensitivity Tests; Protease Inhibitors; Thienamycins	1998
Effects of cilastatin on the pharmacokinetics of a new carbapenem, DA-1131, in rats, rabbits, and dogs. Antimicrobial agents and chemotherapy, 1999, Volume: 43, Issue:10 Topics: Animals; Carbapenems; Cilastatin; Dipeptidases; Dogs; Drug Interactions; Metabolic Clearance Rate; Microvilli; Protease Inhibitors; Rabbits; Rats; Rats, Sprague-Dawley	1999
Carbapenems. Seminars in pediatric infectious diseases, 2002, Volume: 13, Issue:1 Topics: Anti-Bacterial Agents; Bacterial Infections; Carbapenems; Cilastatin; Cilastatin, Imipenem Drug Combination; Clinical Trials as Topic; Drug Administration Schedule; Drug Combinations; Humans; Imipenem; Infant; Infant, Newborn; Infant, Premature	2002
[Antibacterial activity of biapenem against recent clinical isolates]. The Japanese journal of antibiotics, 2003, Volume: 56, Issue:2 Topics: Bacteria; Bacterial Infections; beta-Alanine; Carbapenems; Ceftazidime; Cilastatin; Cilastatin, Imipenem Drug Combination; Drug Combinations; Drug Resistance, Bacterial; Humans; Imipenem; Meropenem; Thienamycins	2003
[Proper use of carbapenem antibiotics based on the feature in the treatment of infectious diseases (discussion)]]. The Japanese journal of antibiotics, 2004, Volume: 57, Issue:1 Topics: Bacteria; Bacterial Infections; beta-Alanine; Carbapenems; Cilastatin; Cilastatin, Imipenem Drug Combination; Drug Administration Schedule; Drug Combinations; Drug Resistance, Bacterial; Humans; Imipenem; Meropenem; Thienamycins; Treatment Failure	2004
Is it safe to use carbapenems in patients with a history of allergy to penicillin? The Journal of antimicrobial chemotherapy, 2004, Volume: 54, Issue:6 Topics: Adult; Aged; Aged, 80 and over; Anti-Bacterial Agents; Carbapenems; Cilastatin; Cilastatin, Imipenem Drug Combination; Cross Reactions; Drug Combinations; Drug Hypersensitivity; Female; Humans; Imipenem; Incidence; Male; Meropenem; Middle Aged; Penicillins; Retrospective Studies; Thienamycins	2004
Effect of carbapenem administration on establishment of intestinal colonization by vancomycin-resistant enterococci and Klebsiella pneumoniae in mice. Antimicrobial agents and chemotherapy, 2007, Volume: 51, Issue:1 Topics: Animals; beta-Lactams; Carbapenems; Ceftriaxone; Cilastatin; Cilastatin, Imipenem Drug Combination; Drug Combinations; Enterococcus; Ertapenem; Female; Imipenem; Intestines; Klebsiella pneumoniae; Mice; Piperacillin; Sodium Chloride; Time Factors; Vancomycin Resistance	2007
CW-270033, a novel pyrrolidinyl-thio carbapenem, has potent antimicrobial activity in vitro and in vivo. Biological & pharmaceutical bulletin, 2007, Volume: 30, Issue:3 Topics: Animals; Anti-Bacterial Agents; Bacteria; Bacterial Infections; Carbapenems; Cilastatin; Dose-Response Relationship, Drug; Enterococcus faecalis; Escherichia coli; Injections, Intravenous; Meropenem; Methicillin Resistance; Mice; Microbial Sensitivity Tests; Molecular Structure; Protease Inhibitors; Pseudomonas aeruginosa; Pyrrolidines; Staphylococcus aureus; Thienamycins; Vancomycin Resistance	2007
First detection of a VIM-1 metallo-beta-lactamase in a carbapenem-resistant Citrobacter freundii clinical isolate in an acute hospital in Germany. Scandinavian journal of infectious diseases, 2007, Volume: 39, Issue:3 Topics: Aged, 80 and over; beta-Lactam Resistance; beta-Lactamases; Carbapenems; Cilastatin; Ciprofloxacin; Citrobacter freundii; Enterobacteriaceae Infections; Female; Germany; Humans; Imipenem; Polymerase Chain Reaction	2007
Pharmacokinetic-pharmacodynamic modeling and simulation for in vivo bactericidal effect in murine infection model. Journal of pharmaceutical sciences, 2008, Volume: 97, Issue:4 Topics: Animals; Anti-Bacterial Agents; Area Under Curve; Bacterial Infections; Carbapenems; Cilastatin; Disease Models, Animal; Doripenem; Female; Imipenem; Meropenem; Mice; Mice, Inbred ICR; Microbial Sensitivity Tests; Models, Biological; Thienamycins	2008
Comparison of in vivo nephrotoxicity in the rabbit by a pyrrolidinyl-thio Carbapenem CW-270031. Journal of microbiology and biotechnology, 2008, Volume: 18, Issue:11 Topics: Animals; Anti-Bacterial Agents; Carbapenems; Cilastatin; Imipenem; Kidney; Kidney Diseases; Male; Meropenem; Pyrrolidines; Rabbits; Thienamycins	2008
[Convulsive liability of an oral carbapenem antibiotic, tebipenem pivoxil]. The Japanese journal of antibiotics, 2009, Volume: 62, Issue:3 Topics: Administration, Oral; Animals; Carbapenems; Cilastatin; Cilastatin, Imipenem Drug Combination; Dose-Response Relationship, Drug; Drug Combinations; Drug Synergism; Imipenem; Infusions, Intravenous; Injections, Intraventricular; Male; Mice; Pentylenetetrazole; Rats; Seizures	2009
Cost-effectiveness model of empiric doripenem compared with imipenem-cilastatin in ventilator-associated pneumonia. Surgical infections, 2010, Volume: 11, Issue:5 Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anti-Bacterial Agents; Carbapenems; Cilastatin; Cilastatin, Imipenem Drug Combination; Cost-Benefit Analysis; Doripenem; Drug Combinations; Humans; Imipenem; Length of Stay; Middle Aged; Pneumonia, Ventilator-Associated; Pseudomonas aeruginosa; Pseudomonas Infections; Quality-Adjusted Life Years; Young Adult	2010
Comparative evaluation of intratracheal colistimethate sodium, imipenem, and meropenem in BALB/c mice with carbapenem-resistant Acinetobacter baumannii pneumonia. International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases, 2012, Volume: 16, Issue:1 Topics: Acinetobacter baumannii; Acinetobacter Infections; Acute Disease; Animals; Anti-Bacterial Agents; Carbapenems; Cilastatin; Cilastatin, Imipenem Drug Combination; Colistin; Cytokines; Disease Models, Animal; Drug Combinations; Drug Resistance, Bacterial; Female; Imipenem; Meropenem; Mice; Mice, Inbred BALB C; Microbial Sensitivity Tests; Pneumonia, Bacterial; Stem Cells; Thienamycins	2012
Antimicrobial susceptibility of gram-negative pathogens isolated from patients with complicated intra-abdominal infections in South African hospitals (SMART Study 2004-2009): impact of the new carbapenem breakpoints. Surgical infections, 2012, Volume: 13, Issue:1 Topics: Anti-Bacterial Agents; Carbapenems; Cilastatin; Cilastatin, Imipenem Drug Combination; Drug Combinations; Drug Resistance, Multiple, Bacterial; Gram-Negative Bacteria; Gram-Negative Bacterial Infections; Humans; Imipenem; Intraabdominal Infections; Microbial Sensitivity Tests; Prevalence; South Africa	2012
Doripenem: excess mortality. Prescrire international, 2012, Volume: 21, Issue:130 Topics: Anti-Bacterial Agents; Carbapenems; Cilastatin; Cilastatin, Imipenem Drug Combination; Doripenem; Drug Combinations; Early Termination of Clinical Trials; Evidence-Based Medicine; Humans; Imipenem; Pneumonia, Ventilator-Associated; Randomized Controlled Trials as Topic; Risk Assessment; Risk Factors; Treatment Outcome	2012
A week seems to be weak: tailoring duration of antibiotic treatment in Gram-negative ventilator-associated pneumonia. Critical care (London, England), 2013, Jan-21, Volume: 17, Issue:1 Topics: Anti-Bacterial Agents; Carbapenems; Cilastatin; Female; Humans; Imipenem; Male; Pneumonia, Ventilator-Associated	2013
Impact of the introduction of real-time therapeutic drug monitoring on empirical doses of carbapenems in critically ill burn patients. Burns : journal of the International Society for Burn Injuries, 2015, Volume: 41, Issue:5 Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anti-Bacterial Agents; Bacterial Infections; Body Surface Area; Burn Units; Burns; Carbapenems; Cilastatin; Cilastatin, Imipenem Drug Combination; Cohort Studies; Computer Systems; Critical Illness; Drug Combinations; Drug Monitoring; Female; Humans; Imipenem; Length of Stay; Male; Meropenem; Middle Aged; Retrospective Studies; Thienamycins; Young Adult	2015
[Comparison of the modified Hodge test and the Carba NP test for detection of carbapenemases in Enterobacteriaceae isolates]. Mikrobiyoloji bulteni, 2016, Volume: 50, Issue:1 Topics: Anti-Bacterial Agents; Bacterial Proteins; beta-Lactamases; Carbapenems; Cilastatin; Enterobacteriaceae; Enzyme Assays; Humans; Imipenem; Microbial Sensitivity Tests; Phenotype; Sensitivity and Specificity	2016
Modification and evaluation of the Carba NP test by use of paper strip for simple and rapid detection of carbapenemase-producing Enterobacteriaceae. World journal of microbiology & biotechnology, 2016, Volume: 32, Issue:7 Topics: Bacterial Proteins; Bacteriological Techniques; beta-Lactamases; Carbapenems; Cilastatin; Cilastatin, Imipenem Drug Combination; Drug Combinations; Enterobacteriaceae; Enterobacteriaceae Infections; Enzyme Assays; Humans; Imipenem; Phenotype; Polymerase Chain Reaction; Pseudomonas; Reagent Strips	2016
A carbapenem antibiotic imipenem/cilastatin induces an oxidative stress-status and gonadotoxic effects in « wistar » rats. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2017, Volume: 95 Topics: Animals; Anti-Bacterial Agents; Carbapenems; Cilastatin; Cilastatin, Imipenem Drug Combination; Dose-Response Relationship, Drug; Drug Combinations; Imipenem; Male; Oxidative Stress; Rats; Rats, Wistar; Spermatozoa; Testis	2017
Imipenem/cilastatin/relebactam: A new carbapenem β-lactamase inhibitor combination. American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists, 2021, 03-31, Volume: 78, Issue:8 Topics: Adolescent; Adult; Anti-Bacterial Agents; Azabicyclo Compounds; Carbapenems; Cilastatin; Cilastatin, Imipenem Drug Combination; Humans; Imipenem; Microbial Sensitivity Tests	2021