Page last updated: 2024-09-04

carbapenems and cilastatin, imipenem drug combination

carbapenems has been researched along with cilastatin, imipenem drug combination in 29 studies

Compound Research Comparison

Studies (carbapenems)	Trials (carbapenems)	Recent Studies (post-2010) (carbapenems)	Studies (cilastatin, imipenem drug combination)	Trials (cilastatin, imipenem drug combination)	Recent Studies (post-2010) (cilastatin, imipenem drug combination)
7,355	147	5,277	473	130	115

Research

Studies (29)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	4 (13.79)	18.2507
2000's	9 (31.03)	29.6817
2010's	12 (41.38)	24.3611
2020's	4 (13.79)	2.80

Authors

Authors	Studies
Burman, LA; Cassinelli, G; Corigli, R; Dornbusch, K; Franceschi, G; Norrby, SR; Sassella, D	1
Fanta, J; Felbr, O; Lochmann, O; Pelák, Z; Vyhnánek, F	1
Cama, L; Kropp, H; Sasor, MW; Sundelof, JG; Thompson, R; White, KM	1
Blanquer, J; Cobo, L; Corcia, S; Daguerre, M; de Latorre, FJ; Del Nogal, F; Garau, J; León, C; Net, A; Rello, J	1
Pietroski, N; Schlossberg, D	1
Cravarezza, P; Donati, P; Franchino, L; Grassi, V; Pozzi, A; Prometti, P; Ravizzola, G; Romanelli, G; Zulli, R	1
Mikamo, H; Ninomiya, M; Tamaya, T	1
Araake, M; Hara, T; Watabe, H	1
Inoue, M; Kaku, M; Nasu, M; Sagawa, K; Yokoyama, T	1
Axtell, SS; Callahan, J; Shekar, R; Sodhi, M	1
Donskey, CJ; Pultz, NJ; Stiefel, U	1
Archontoulis, N; Giamarellos-Bourboulis, EJ; Giamarellou, H; Mega, A; Pavleas, I; Rigas, K; Thomopoulos, G; Vernikos, P	1
Kurata, Y; Kurosawa, T; Nawa, T; Shibasaki, S; Suzuki, H; Yagi, Y	1
Chen, J; Mody, SH; Shorr, AF; Zilberberg, MD	1
Bonomo, RA; Endimiani, A; Papp-Wallace, KM; Taracila, MA	1
Chen, CC; Chen, CH; Chiang, SR; Chuang, YC; Ko, WC; Lee, NY; Shieh, JM; Tang, HJ	1
Badal, RE; Boffard, KD; Botha, RF; Brink, AJ; Feldman, C; Grolman, DC; Joubert, I; Poswa, X; Pretorius, J; Richards, GA; Senekal, M; Veller, M	1
Kurtinecz, M; Li, G; Mitrani-Gold, FS; Mundy, LM; Singh, KP; Tomayko, JF; Wetherington, J	1
Cannon, JP; Clark, NM; Grim, SA; Lee, TA; Setlak, P	1
Igarashi, Y; Inui, K; Ohara, H; Ryozawa, S; Tazuma, S; Tsuyuguchi, T	1
Decosterd, LA; Eggimann, P; Fournier, A; Marchetti, O; Pagani, JL; Pannatier, A; Que, YA; Revelly, JP; Voirol, P	1
Chanawong, A; Charoensri, N; Lulitanond, A; Piyapatthanakul, S; Srisrattakarn, A; Supajeen, A; Wilailuckana, C; Wonglakorn, L	1
Boudawara, T; Daoud, S; Kallel, R; Ksouda, K; Sahnoun, Z; Tahri, A; Zeghal, KM	1
Hsu, AJ; Tamma, PD	1
Li, X; Lu, C; Sun, S; Wang, D; Wang, Y	1
Chahine, EB; Karaoui, LR; Mansour, H; Ouweini, AEL	1
Courtois, R; Danneels, P; Dubée, V; Eveillard, M; Kempf, M; Mahieu, R; Quinqueneau, C; Rihet, C; Vannier, C	1
Luo, Q; Shen, P; Xiao, Y; Xiong, L; Yu, W	1

Reviews

5 review(s) available for carbapenems and cilastatin, imipenem drug combination

Article	Year
Carbapenems: past, present, and future. Antimicrobial agents and chemotherapy, 2011, Volume: 55, Issue:11 Topics: Anti-Bacterial Agents; beta-Alanine; beta-Lactams; Carbapenems; Cilastatin; Cilastatin, Imipenem Drug Combination; Doripenem; Drug Combinations; Ertapenem; Humans; Imipenem; Thienamycins	2011
Systematic review and meta-analysis of antimicrobial treatment effect estimation in complicated urinary tract infection. Antimicrobial agents and chemotherapy, 2013, Volume: 57, Issue:11 Topics: Anti-Bacterial Agents; Carbapenems; Cilastatin; Cilastatin, Imipenem Drug Combination; Clinical Trials as Topic; Databases, Bibliographic; Doripenem; Drug Combinations; Female; Humans; Imipenem; Levofloxacin; Male; Research Design; Treatment Outcome; Urinary Tract Infections	2013
The risk of seizures among the carbapenems: a meta-analysis. The Journal of antimicrobial chemotherapy, 2014, Volume: 69, Issue:8 Topics: Adult; Anti-Bacterial Agents; beta-Lactams; Carbapenems; Child; Cilastatin; Cilastatin, Imipenem Drug Combination; Doripenem; Drug Combinations; Ertapenem; Humans; Imipenem; Meropenem; Risk; Seizures; Thienamycins	2014
Defining the Role of Novel β-Lactam Agents That Target Carbapenem-Resistant Gram-Negative Organisms. Journal of the Pediatric Infectious Diseases Society, 2019, Jul-01, Volume: 8, Issue:3 Topics: Anti-Bacterial Agents; Azabicyclo Compounds; Aztreonam; Boronic Acids; Carbapenems; Cefiderocol; Ceftazidime; Cephalosporins; Cilastatin, Imipenem Drug Combination; Drug Combinations; Drug Resistance, Multiple, Bacterial; Gram-Negative Bacteria; Gram-Negative Bacterial Infections; Heterocyclic Compounds, 1-Ring; Meropenem; Tazobactam	2019
Efficacy and safety of novel carbapenem-β-lactamase inhibitor combinations: Results from phase II and III trials. Frontiers in cellular and infection microbiology, 2022, Volume: 12 Topics: beta-Lactamase Inhibitors; Carbapenems; Cilastatin, Imipenem Drug Combination; Clinical Trials, Phase II as Topic; Clinical Trials, Phase III as Topic; Drug Combinations; Humans; Meropenem; Microbial Sensitivity Tests	2022

Trials

6 trial(s) available for carbapenems and cilastatin, imipenem drug combination

Article	Year
Pharmacokinetics in healthy subjects of FCE 22101 and its acetoxymethyl ester, FCE 22891: effect of co-administration of imipenem/cilastatin on the renal metabolism of FCE 22101. The Journal of antimicrobial chemotherapy, 1990, Volume: 25, Issue:3 Topics: Adult; Anti-Bacterial Agents; Carbapenems; Chromatography, High Pressure Liquid; Cilastatin; Cilastatin, Imipenem Drug Combination; Dipeptidases; Drug Combinations; Drug Interactions; Drug Therapy, Combination; Humans; Imipenem; Kidney; Lactams; Male; Reference Values	1990
Prospective, randomised, multicentre study of meropenem versus imipenem/cilastatin as empiric monotherapy in severe nosocomial infections. European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology, 1997, Volume: 16, Issue:11 Topics: Adolescent; Adult; Aged; Aged, 80 and over; Carbapenems; Cilastatin; Cilastatin, Imipenem Drug Combination; Cross Infection; Drug Combinations; Drug Therapy, Combination; Female; Humans; Imipenem; Male; Meropenem; Middle Aged; Prospective Studies; Thienamycins	1997
Carbapenems in the treatment of severe community-acquired pneumonia in hospitalized elderly patients: a comparative study against standard therapy. Journal of chemotherapy (Florence, Italy), 2002, Volume: 14, Issue:6 Topics: Aged; Aged, 80 and over; Anti-Bacterial Agents; Carbapenems; Ceftriaxone; Cilastatin; Cilastatin, Imipenem Drug Combination; Clarithromycin; Community-Acquired Infections; Costs and Cost Analysis; Drug Combinations; Drug Costs; Drug Therapy, Combination; Female; Hospitalization; Humans; Imipenem; Male; Meropenem; Pneumonia, Bacterial; Prospective Studies; Thienamycins; Treatment Outcome	2002
[Investigation on administration method of carbapenems]. The Japanese journal of antibiotics, 2002, Volume: 55, Issue:6 Topics: Adult; Aged; beta-Alanine; Body Temperature; C-Reactive Protein; Carbapenems; Cilastatin; Cilastatin, Imipenem Drug Combination; Drug Administration Schedule; Drug Combinations; Female; Humans; Imipenem; Leukocyte Count; Meropenem; Middle Aged; Parametritis; Thienamycins	2002
Impact of carbapenem administration on systemic endotoxemia in patients with severe sepsis and Gram-negative bacteremia. Journal of chemotherapy (Florence, Italy), 2006, Volume: 18, Issue:5 Topics: Aged; Aged, 80 and over; Anti-Bacterial Agents; Bacteremia; C-Reactive Protein; Carbapenems; Cilastatin; Cilastatin, Imipenem Drug Combination; Drug Combinations; Endotoxemia; Female; Gram-Negative Bacterial Infections; Humans; Imipenem; Interleukin-6; Lipopolysaccharides; Male; Middle Aged; Pneumonia, Ventilator-Associated; Sepsis	2006
Clinical efficacy of intravenous doripenem in patients with acute biliary tract infection: a multicenter, randomized, controlled trial with imipenem/cilastatin as comparator. Journal of gastroenterology, 2015, Volume: 50, Issue:2 Topics: Acute Disease; Adult; Aged; Aged, 80 and over; Anti-Bacterial Agents; Bacterial Infections; Body Temperature; C-Reactive Protein; Carbapenems; Cholangitis; Cholecystitis, Acute; Cilastatin; Cilastatin, Imipenem Drug Combination; Doripenem; Drug Combinations; Female; Humans; Imipenem; Infusions, Intravenous; Male; Middle Aged; Treatment Outcome; Young Adult	2015

Other Studies

18 other study(ies) available for carbapenems and cilastatin, imipenem drug combination

Article	Year
[New approaches in the use of antibiotics in the treatment of postoperative intra-abdominal infections]. Rozhledy v chirurgii : mesicnik Ceskoslovenske chirurgicke spolecnosti, 1995, Volume: 74, Issue:3 Topics: Abdomen; Adolescent; Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Bacterial Infections; Carbapenems; Cilastatin; Cilastatin, Imipenem Drug Combination; Drug Combinations; Female; Humans; Imipenem; Male; Middle Aged; Postoperative Complications	1995
Pharmacokinetics in nonhuman primates of a prototype carbapenem active against methicillin-resistant Staphylococcus aureus. Antimicrobial agents and chemotherapy, 1996, Volume: 40, Issue:3 Topics: Animals; Anti-Bacterial Agents; Carbapenems; Cilastatin; Cilastatin, Imipenem Drug Combination; Dipeptidases; Drug Combinations; Drug Therapy, Combination; Half-Life; Imidazoles; Imipenem; Injections, Intravenous; Kidney; Macaca mulatta; Male; Methicillin Resistance; Pan troglodytes; Staphylococcus aureus	1996
Carbapenems. Seminars in pediatric infectious diseases, 2002, Volume: 13, Issue:1 Topics: Anti-Bacterial Agents; Bacterial Infections; Carbapenems; Cilastatin; Cilastatin, Imipenem Drug Combination; Clinical Trials as Topic; Drug Administration Schedule; Drug Combinations; Humans; Imipenem; Infant; Infant, Newborn; Infant, Premature	2002
[Antibacterial activity of biapenem against recent clinical isolates]. The Japanese journal of antibiotics, 2003, Volume: 56, Issue:2 Topics: Bacteria; Bacterial Infections; beta-Alanine; Carbapenems; Ceftazidime; Cilastatin; Cilastatin, Imipenem Drug Combination; Drug Combinations; Drug Resistance, Bacterial; Humans; Imipenem; Meropenem; Thienamycins	2003
[Proper use of carbapenem antibiotics based on the feature in the treatment of infectious diseases (discussion)]]. The Japanese journal of antibiotics, 2004, Volume: 57, Issue:1 Topics: Bacteria; Bacterial Infections; beta-Alanine; Carbapenems; Cilastatin; Cilastatin, Imipenem Drug Combination; Drug Administration Schedule; Drug Combinations; Drug Resistance, Bacterial; Humans; Imipenem; Meropenem; Thienamycins; Treatment Failure	2004
Is it safe to use carbapenems in patients with a history of allergy to penicillin? The Journal of antimicrobial chemotherapy, 2004, Volume: 54, Issue:6 Topics: Adult; Aged; Aged, 80 and over; Anti-Bacterial Agents; Carbapenems; Cilastatin; Cilastatin, Imipenem Drug Combination; Cross Reactions; Drug Combinations; Drug Hypersensitivity; Female; Humans; Imipenem; Incidence; Male; Meropenem; Middle Aged; Penicillins; Retrospective Studies; Thienamycins	2004
Effect of carbapenem administration on establishment of intestinal colonization by vancomycin-resistant enterococci and Klebsiella pneumoniae in mice. Antimicrobial agents and chemotherapy, 2007, Volume: 51, Issue:1 Topics: Animals; beta-Lactams; Carbapenems; Ceftriaxone; Cilastatin; Cilastatin, Imipenem Drug Combination; Drug Combinations; Enterococcus; Ertapenem; Female; Imipenem; Intestines; Klebsiella pneumoniae; Mice; Piperacillin; Sodium Chloride; Time Factors; Vancomycin Resistance	2007
[Convulsive liability of an oral carbapenem antibiotic, tebipenem pivoxil]. The Japanese journal of antibiotics, 2009, Volume: 62, Issue:3 Topics: Administration, Oral; Animals; Carbapenems; Cilastatin; Cilastatin, Imipenem Drug Combination; Dose-Response Relationship, Drug; Drug Combinations; Drug Synergism; Imipenem; Infusions, Intravenous; Injections, Intraventricular; Male; Mice; Pentylenetetrazole; Rats; Seizures	2009
Cost-effectiveness model of empiric doripenem compared with imipenem-cilastatin in ventilator-associated pneumonia. Surgical infections, 2010, Volume: 11, Issue:5 Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anti-Bacterial Agents; Carbapenems; Cilastatin; Cilastatin, Imipenem Drug Combination; Cost-Benefit Analysis; Doripenem; Drug Combinations; Humans; Imipenem; Length of Stay; Middle Aged; Pneumonia, Ventilator-Associated; Pseudomonas aeruginosa; Pseudomonas Infections; Quality-Adjusted Life Years; Young Adult	2010
Comparative evaluation of intratracheal colistimethate sodium, imipenem, and meropenem in BALB/c mice with carbapenem-resistant Acinetobacter baumannii pneumonia. International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases, 2012, Volume: 16, Issue:1 Topics: Acinetobacter baumannii; Acinetobacter Infections; Acute Disease; Animals; Anti-Bacterial Agents; Carbapenems; Cilastatin; Cilastatin, Imipenem Drug Combination; Colistin; Cytokines; Disease Models, Animal; Drug Combinations; Drug Resistance, Bacterial; Female; Imipenem; Meropenem; Mice; Mice, Inbred BALB C; Microbial Sensitivity Tests; Pneumonia, Bacterial; Stem Cells; Thienamycins	2012
Antimicrobial susceptibility of gram-negative pathogens isolated from patients with complicated intra-abdominal infections in South African hospitals (SMART Study 2004-2009): impact of the new carbapenem breakpoints. Surgical infections, 2012, Volume: 13, Issue:1 Topics: Anti-Bacterial Agents; Carbapenems; Cilastatin; Cilastatin, Imipenem Drug Combination; Drug Combinations; Drug Resistance, Multiple, Bacterial; Gram-Negative Bacteria; Gram-Negative Bacterial Infections; Humans; Imipenem; Intraabdominal Infections; Microbial Sensitivity Tests; Prevalence; South Africa	2012
Doripenem: excess mortality. Prescrire international, 2012, Volume: 21, Issue:130 Topics: Anti-Bacterial Agents; Carbapenems; Cilastatin; Cilastatin, Imipenem Drug Combination; Doripenem; Drug Combinations; Early Termination of Clinical Trials; Evidence-Based Medicine; Humans; Imipenem; Pneumonia, Ventilator-Associated; Randomized Controlled Trials as Topic; Risk Assessment; Risk Factors; Treatment Outcome	2012
Impact of the introduction of real-time therapeutic drug monitoring on empirical doses of carbapenems in critically ill burn patients. Burns : journal of the International Society for Burn Injuries, 2015, Volume: 41, Issue:5 Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anti-Bacterial Agents; Bacterial Infections; Body Surface Area; Burn Units; Burns; Carbapenems; Cilastatin; Cilastatin, Imipenem Drug Combination; Cohort Studies; Computer Systems; Critical Illness; Drug Combinations; Drug Monitoring; Female; Humans; Imipenem; Length of Stay; Male; Meropenem; Middle Aged; Retrospective Studies; Thienamycins; Young Adult	2015
Modification and evaluation of the Carba NP test by use of paper strip for simple and rapid detection of carbapenemase-producing Enterobacteriaceae. World journal of microbiology & biotechnology, 2016, Volume: 32, Issue:7 Topics: Bacterial Proteins; Bacteriological Techniques; beta-Lactamases; Carbapenems; Cilastatin; Cilastatin, Imipenem Drug Combination; Drug Combinations; Enterobacteriaceae; Enterobacteriaceae Infections; Enzyme Assays; Humans; Imipenem; Phenotype; Polymerase Chain Reaction; Pseudomonas; Reagent Strips	2016
A carbapenem antibiotic imipenem/cilastatin induces an oxidative stress-status and gonadotoxic effects in « wistar » rats. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2017, Volume: 95 Topics: Animals; Anti-Bacterial Agents; Carbapenems; Cilastatin; Cilastatin, Imipenem Drug Combination; Dose-Response Relationship, Drug; Drug Combinations; Imipenem; Male; Oxidative Stress; Rats; Rats, Wistar; Spermatozoa; Testis	2017
In vitro interactions of ambroxol hydrochloride or amlodipine in combination with antibacterial agents against carbapenem-resistant Acinetobacter baumannii. Letters in applied microbiology, 2020, Volume: 70, Issue:3 Topics: Acinetobacter baumannii; Acinetobacter Infections; Ambroxol; Amlodipine; Anti-Bacterial Agents; Carbapenems; Cefoperazone; Cilastatin, Imipenem Drug Combination; Drug Combinations; Drug Resistance, Bacterial; Drug Synergism; Humans; Meropenem; Microbial Sensitivity Tests; Sulbactam; Thienamycins	2020
Imipenem/cilastatin/relebactam: A new carbapenem β-lactamase inhibitor combination. American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists, 2021, 03-31, Volume: 78, Issue:8 Topics: Adolescent; Adult; Anti-Bacterial Agents; Azabicyclo Compounds; Carbapenems; Cilastatin; Cilastatin, Imipenem Drug Combination; Humans; Imipenem; Microbial Sensitivity Tests	2021
Cefoxitin-based combination for ESBL-producing Enterobacteriaceae endocarditis. Infectious diseases now, 2022, Volume: 52, Issue:7 Topics: Anti-Bacterial Agents; beta-Lactamases; Carbapenems; Cefoxitin; Cilastatin, Imipenem Drug Combination; Ciprofloxacin; Endocarditis; Enterobacteriaceae; Escherichia coli; Escherichia coli Infections; Fosfomycin; Humans; Microbial Sensitivity Tests; Urinary Tract Infections	2022