carbamazepine epoxide has been researched along with valproic acid in 29 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 8 (27.59) | 18.7374 |
| 1990's | 14 (48.28) | 18.2507 |
| 2000's | 5 (17.24) | 29.6817 |
| 2010's | 2 (6.90) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Huber, VJ; Kwee, IL; Nakada, T; Tsujita, M | 1 |
| Blacklaw, J; Brodie, MJ; Butler, E; Gillham, RA; McKee, PJ | 1 |
| Lindhout, D; Meijer, JW; Meinardi, H; Nau, H | 1 |
| Hosoda, N; Miura, H; Shirai, H; Sunaoshi, W; Takanashi, S | 1 |
| Eugster, HP; Hinnen, A; Meyer, UA; Sengstag, C; Würgler, FE | 1 |
| Boenigk, HE; May, T; Rambeck, B; Sälke-Treumann, A | 1 |
| Briggle, TV; Guterman, A; McManus, DQ; Perchalski, R; Ramsay, RE; Vazquez, D; Wong, P; Yost, RA | 1 |
| Baumann, RJ; Chang, SL; Kuhn, R; Levy, RH; Robbins, DK; Wedlund, PJ | 1 |
| Horibe, Y; Ito, Y; Iwaki, M; Ogiso, T | 1 |
| Jürgens, U; May, T; Rambeck, B; Schnabel, R; Villagrán, R | 1 |
| Eddy, AC; Guyot, M; Kerr, BM; Levy, RH; Loiseau, P; Rettie, AE; Wilensky, AJ | 1 |
| Bertilsson, L; Fazio, A; Oteri, G; Perucca, E; Pisani, F; Spina, E | 1 |
| Chang, SL; Levy, RH | 1 |
| Binnie, CD; de Beer-Pawlikowski, NK; Debets, RM; Meijer, JW; van Parys, JA | 1 |
| Colin, L; Friel, PN; Johno, I; Koch, K; Levy, RH; Linthicum, LM; Raisys, VA; Temkin, NR; Wilensky, AJ | 1 |
| Brachet-Liermain, A; Guyot, M; Levy, RH; Loiseau, P; Moreland, TA; Morselli, PL | 1 |
| Brett, EM; Elyas, AA; Lascelles, PT; Schoeman, JF | 2 |
| Delgado, MR; Liu, H | 1 |
| Camfield, CS; Camfield, PR; Dooley, JM; Fraser, AD; Gordon, KE | 1 |
| Eugster, HP; Sengstag, C | 1 |
| Bernus, I; Dickinson, RG; Eadie, MJ; Hooper, WD | 1 |
| Donnelly, A; Potter, JM | 1 |
| Miura, H | 1 |
| Getova, DP; Minkova, GD | 1 |
| Jiao, Z; Shi, XJ; Zhao, ZG; Zhong, MK | 1 |
| Beutler, AS; Li, S; Nicol, R; Walsh, MJ | 1 |
| Breton, H; Demoly, P; Gelisse, P; Hillaire-Buys, D; Mathieu, O; Picot, MC | 1 |
| Brozmanova, H; Grundmann, M; Kacirova, I | 1 |
4 trial(s) available for carbamazepine epoxide and valproic acid
| Article | Year |
|---|---|
The mechanism of the carbamazepine-valproate interaction in humans.
Topics: Adult; Anticonvulsants; Carbamazepine; Drug Therapy, Combination; Epilepsy; Female; Humans; Male; Middle Aged; Valproic Acid | 1997 |
Developmental and therapeutic pharmacology of antiepileptic drugs.
Topics: Adolescent; Adult; Age Factors; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Drug Administration Schedule; Drug Industry; Drug Interactions; Drug Monitoring; Drug Therapy, Combination; Epilepsies, Partial; Epilepsy; Half-Life; Humans; Infant; Intestinal Absorption; Isoxazoles; Lamotrigine; Prospective Studies; Treatment Outcome; Triazines; Valproic Acid; Zonisamide | 2000 |
Influence of carbamazepine-10,11-epoxide on the serum level of valproic acid in epileptic patients on combined treatment with carbamazepine and valproic acid.
Topics: Adolescent; Adult; Age Factors; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Drug Interactions; Drug Therapy, Combination; Epilepsy; Humans; Middle Aged; Valproic Acid | 2000 |
Effects of carbamazepine and metabolites on IL-2, IL-5, IL-6, IL-10 and IFN-γ secretion in epileptic patients: the influence of co-medication.
Topics: Acridines; Adult; Aged; Anticonvulsants; Carbamazepine; Dibenzazepines; Drug Therapy, Combination; Epilepsy; Female; Humans; Interferon-gamma; Interleukins; Lamotrigine; Male; Middle Aged; Th1 Cells; Th2 Cells; Triazines; Valproic Acid; Young Adult | 2011 |
25 other study(ies) available for carbamazepine epoxide and valproic acid
| Article | Year |
|---|---|
Inhibition of aquaporin 4 by antiepileptic drugs.
Topics: Animals; Anticonvulsants; Aquaporin 4; Computer Simulation; Drug Evaluation, Preclinical; Humans; Oocytes; Protein Binding; Thermodynamics; Xenopus | 2009 |
Variability and clinical relevance of the interaction between sodium valproate and carbamazepine in epileptic patients.
Topics: Adolescent; Adult; Carbamazepine; Cognition; Drug Interactions; Epilepsy; Female; Humans; Male; Middle Aged; Valproic Acid | 1992 |
Antiepileptic drugs and teratogenesis in two consecutive cohorts: changes in prescription policy paralleled by changes in pattern of malformations.
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Carbamazepine; Cohort Studies; Drug Prescriptions; Epilepsy; Female; Humans; Infant; Infant, Newborn; Male; Phenobarbital; Phenytoin; Pregnancy; Pregnancy Complications; Valproic Acid | 1992 |
Influence of concurrent administration of sodium valproate on the plasma concentrations of carbamazepine and its epoxide and diol metabolites.
Topics: Adolescent; Adult; Carbamazepine; Child; Child, Preschool; Drug Therapy, Combination; Epilepsy; Female; Humans; Male; Valproic Acid | 1991 |
Heterologous expression of human microsomal epoxide hydrolase in Saccharomyces cerevisiae. Study of the valpromide-carbamazepine epoxide interaction.
Topics: Base Sequence; Carbamazepine; Drug Interactions; Epoxide Hydrolases; Epoxy Compounds; Gene Expression Regulation, Enzymologic; Humans; Kinetics; Microsomes; Molecular Sequence Data; Saccharomyces cerevisiae; Styrenes; Valproic Acid | 1991 |
Valproic acid-induced carbamazepine-10,11-epoxide toxicity in children and adolescents.
Topics: Adolescent; Adult; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Drug Interactions; Epilepsy; Female; Humans; Infant; Male; Valproic Acid | 1990 |
Carbamazepine metabolism in humans: effect of concurrent anticonvulsant therapy.
Topics: Administration, Oral; Adolescent; Adult; Carbamazepine; Chromatography, High Pressure Liquid; Drug Interactions; Drug Therapy, Combination; Epilepsy; Female; Half-Life; Humans; Male; Middle Aged; Phenobarbital; Phenytoin; Protein Binding; Valproic Acid | 1990 |
Inhibition of epoxide hydrolase by valproic acid in epileptic patients receiving carbamazepine.
Topics: Adolescent; Blood Proteins; Carbamazepine; Child; Epilepsy; Epoxide Hydrolases; Female; Humans; Male; Protein Binding; Valproic Acid | 1990 |
Inhibitory effect of valproic acid on metabolic clearance of carbamazepine epoxide.
Topics: Animals; Arabidopsis Proteins; Carbamazepine; Glucosyltransferases; Male; Rats; Rats, Inbred Strains; Time Factors; Valproic Acid | 1990 |
Postmortem serum protein binding and brain concentrations of antiepileptic drugs in autoptic specimens from 45 epileptic patients.
Topics: Anticonvulsants; Blood Proteins; Brain; Carbamazepine; Epilepsy; Female; Humans; Male; Phenobarbital; Phenytoin; Protein Binding; Valproic Acid | 1990 |
Inhibition of human liver microsomal epoxide hydrolase by valproate and valpromide: in vitro/in vivo correlation.
Topics: Anticonvulsants; Carbamazepine; Drug Interactions; Epoxide Hydrolases; Epoxy Compounds; Humans; Hydrolysis; In Vitro Techniques; Male; Microsomes, Liver; Valproic Acid | 1989 |
Effect of valpromide on the pharmacokinetics of carbamazepine-10, 11-epoxide.
Topics: Adolescent; Adult; Anticonvulsants; Carbamazepine; Female; Half-Life; Humans; Male; Middle Aged; Valproic Acid | 1988 |
Inhibition of epoxidation of carbamazepine by valproic acid in the isolated perfused rat liver.
Topics: Animals; Carbamazepine; Chromatography, High Pressure Liquid; In Vitro Techniques; Injections, Intraperitoneal; Liver; Male; Metabolic Clearance Rate; Rats; Rats, Inbred Strains; Valproic Acid | 1985 |
Possible hazard of valpromide-carbamazepine combination therapy in epilepsy.
Topics: Anticonvulsants; Carbamazepine; Drug Synergism; Drug Therapy, Combination; Epilepsy; Humans; Valproic Acid | 1984 |
Filtration for free drug level monitoring: carbamazepine and valproic acid.
Topics: Blood Proteins; Carbamazepine; Chromatography, Gas; Dialysis; Filtration; Humans; Protein Binding; Valproic Acid | 1984 |
Carbamazepine/valproic acid interaction in man and rhesus monkey.
Topics: Adolescent; Adult; Animals; Carbamazepine; Child; Dose-Response Relationship, Drug; Drug Interactions; Epilepsy; Female; Humans; Macaca mulatta; Male; Middle Aged; Valproic Acid | 1984 |
Altered ratio of carbamazepine-10,11-epoxide/carbamazepine in plasma of children: evidence of anticonvulsant drug interaction.
Topics: Anticonvulsants; Carbamazepine; Child; Chromatography, Gas; Chromatography, High Pressure Liquid; Drug Interactions; Drug Therapy, Combination; Epilepsy; Humans; Valproic Acid | 1984 |
Correlation between plasma carbamazepine-10,11-epoxide concentration and drug side-effects in children with epilepsy.
Topics: Adolescent; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Drug Therapy, Combination; Epilepsy; Humans; Valproic Acid | 1984 |
The influence of polytherapy on the relationships between serum carbamazepine and its metabolites in epileptic children.
Topics: Aging; Anticonvulsants; Body Weight; Carbamazepine; Child; Chromatography, High Pressure Liquid; Drug Interactions; Drug Therapy, Combination; Epilepsy; Female; Humans; Male; Spectrophotometry, Ultraviolet; Valproic Acid | 1994 |
The use of antiepileptic drug levels in children: a survey of Canadian pediatric neurologists.
Topics: Adolescent; Anticonvulsants; Attitude of Health Personnel; Carbamazepine; Child; Epilepsy; Ethosuximide; Female; Humans; Male; Phenobarbital; Valproic Acid | 1993 |
Saccharomyces cerevisiae: an alternative source for human microsomal liver enzymes and its use in drug interaction studies.
Topics: Anticonvulsants; Benzoflavones; Carbamazepine; Cloning, Molecular; Cytochrome P-450 CYP1A2; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; DNA, Complementary; Drug Interactions; Epoxide Hydrolases; Humans; Ketoconazole; Microsomes, Liver; Oxidoreductases, N-Demethylating; Saccharomyces cerevisiae; Valproic Acid | 1993 |
Carbamazepine-10,11-epoxide in therapeutic drug monitoring.
Topics: Adult; Anticonvulsants; Carbamazepine; Chromatography, High Pressure Liquid; Drug Interactions; Drug Monitoring; Female; Fluorescence Polarization Immunoassay; Humans; Lamotrigine; Phenytoin; Sodium Channels; Triazines; Valproic Acid | 1998 |
Population pharmacokinetic modeling of steady state clearance of carbamazepine and its epoxide metabolite from sparse routine clinical data.
Topics: Administration, Oral; Adolescent; Adult; Anticonvulsants; Asian People; Body Weight; Carbamazepine; Chromatography, High Pressure Liquid; Drug Administration Schedule; Drug Therapy, Combination; Female; Humans; Male; Metabolic Clearance Rate; Methods; Models, Biological; Pharmacokinetics; Phenobarbital; Phenytoin; Regression Analysis; Valproic Acid | 2004 |
Carbamazepine is an inhibitor of histone deacetylases.
Topics: Acetylation; Anticonvulsants; Carbamazepine; Cell Line, Tumor; Dose-Response Relationship, Drug; Enzyme Inhibitors; Hepatocytes; Histone Deacetylase Inhibitors; Histone Deacetylases; Histones; Humans; Valproic Acid | 2005 |
Concentrations of carbamazepine and carbamazepine-10,11-epoxide in maternal and umbilical cord blood at birth: Influence of co-administration of valproic acid or enzyme-inducing antiepileptic drugs.
Topics: Adolescent; Adult; Anticonvulsants; Blood Chemical Analysis; Carbamazepine; Dose-Response Relationship, Drug; Drug Interactions; Drug Therapy, Combination; Epilepsy; Female; Fetal Blood; Humans; Pregnancy; Pregnancy Complications; Retrospective Studies; Valproic Acid; Young Adult | 2016 |