carbamazepine epoxide has been researched along with carbamazepine in 287 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 105 (36.59) | 18.7374 |
| 1990's | 109 (37.98) | 18.2507 |
| 2000's | 36 (12.54) | 29.6817 |
| 2010's | 33 (11.50) | 24.3611 |
| 2020's | 4 (1.39) | 2.80 |
| Authors | Studies |
|---|---|
| Blake, JF; Curatolo, WJ; Lombardo, F | 1 |
| Abdelrahman, A; Dosa, S; El-Tayeb, A; Hinz, S; Müller, CE; Tian, M; Weinhausen, S; Weyer, S | 1 |
| Eadie, MJ; McKauge, L; Tyrer, JH | 2 |
| Rosenmund, H; Wad, N | 1 |
| Artesi, C; Fazio, A; Oteri, G; Perucca, E; Pisani, F; Spina, E; Tomson, T | 1 |
| Gorkov, VA; Kudriakova, TB; Rozova, GI; Sirota, LA | 1 |
| Bonneton, J; Genton, P; Mesdjian, E | 1 |
| Blacklaw, J; Brodie, MJ; Butler, E; Gillham, RA; McKee, PJ | 2 |
| He, J; Nakagawa, T; Shibukawa, A | 1 |
| Campestrini, J; Godbillon, J; Le Clanche, V; Lecaillon, JB; Rouan, MC | 1 |
| Lindhout, D; Meijer, JW; Meinardi, H; Nau, H | 1 |
| Breckenridge, AM; Guenthner, TM; Kitteringham, NR; Park, BK; Pirmohamed, M | 1 |
| Perrett, JE; Richens, A; Tsanaclis, LM; Wicks, JF; Williams, J; Wilson, JF | 1 |
| Duncan, JS; Elyas, AA; Patsalos, PN; Prevett, M; Warner, T | 1 |
| al-Quadah, AK; Camfield, C; Camfield, P; Fraser, A; Hwang, P; Soldin, S | 1 |
| Doorschot, CH; Loonen, AJ; Nijdam, JR; van Bavel, LP | 1 |
| Aleksandrowicz, J; Bowmer, CJ; Cawood, A; Forsythe, WI; Hartley, R | 1 |
| Hosoda, N; Miura, H; Shirai, H; Sunaoshi, W; Takanashi, S | 1 |
| Bertilsson, L; Tomson, T | 2 |
| Alric, R; Blayac, JP; Cociglio, M; Hue, B; Lonjon, R; Petit, P; Pouget, R; Sluzewska, A | 1 |
| Bidlingmeyer, BA; Schmitz, S; Warren, FV | 1 |
| Bidlingmeyer, BA; Grohs, RA; Warren, FV | 1 |
| Carter, JG; D'Mello, AP; D'Souza, MJ; Grimsley, SR; Jann, MW | 1 |
| Chan, KK; Riad, LE; Sawchuk, RJ | 2 |
| Anttila, M; Heinonen, E; Kaski, M; Sivenius, J; Tuominen, J | 1 |
| Eugster, HP; Hinnen, A; Meyer, UA; Sengstag, C; Würgler, FE | 1 |
| Forsythe, WI; Hartley, R; Lucock, MD; McLain, B; Ng, PC | 1 |
| Fazio, A; Martines, C; Pisani, F; Spina, E; Tomson, T; Trio, R | 1 |
| Bentrop, D; Bidlingmeyer, BA; Schmitz, S; Warren, FV | 1 |
| Boenigk, HE; May, T; Rambeck, B; Sälke-Treumann, A | 1 |
| Arvidsson, J; Eeg-Olofsson, O; Grahn, PA; Gylje, H; Larsson, C; Nilsson, HL; Norén, L; Tonnby, B | 1 |
| Briggle, TV; Guterman, A; McManus, DQ; Perchalski, R; Ramsay, RE; Vazquez, D; Wong, P; Yost, RA | 1 |
| Baumann, RJ; Chang, SL; Kuhn, R; Levy, RH; Robbins, DK; Wedlund, PJ | 1 |
| Horibe, Y; Ito, Y; Iwaki, M; Ogiso, T | 1 |
| Chang, TY; Liu, LT; Wang, RB; Yiu, CH | 1 |
| Dimanico, U; Gianelli, M; Monaco, F; Mutani, R | 1 |
| Jürgens, U; May, T; Rambeck, B; Schnabel, R; Villagrán, R | 2 |
| Bowmer, CJ; Forsythe, WI; Hartley, R; Lucock, MD; McLain, B; Ng, PC | 1 |
| Amendola D'Agostino, AM; Fazio, A; Ioculano, MP; Oteri, G; Pisani, F; Spina, E | 1 |
| Graves, NM; Miller, SA; Remmel, RP | 1 |
| Couet, W; Fourtillan, JB; Girault, J; Ingrand, I; Istin, B | 1 |
| Patsalos, PN | 1 |
| Cloyd, JC; Remmel, RP; Sinz, MW | 1 |
| Almkvist, O; Bertilsson, L; Nilsson, BY; Svensson, JO; Tomson, T | 1 |
| De Salamanca, RE; Diaz-Obregón, C; Muñoz, JJ; Timoneda, FL | 1 |
| Benetello, P; Furlanut, M; Perlotto, N | 1 |
| Eddy, AC; Guyot, M; Kerr, BM; Levy, RH; Loiseau, P; Rettie, AE; Wilensky, AJ | 1 |
| Eadie, MJ; Herkes, GK; McKinnon, GE | 1 |
| Bao, JQ; Gao, QZ; He, XY; Hu, DM; Wang, KM | 1 |
| Dyer, RD; Oles, KS; Penry, JK | 1 |
| Hönack, D; Löscher, W | 1 |
| Howald, WN; Kalhorn, TF; Levy, RH; Moor, MJ; Rashed, MS | 1 |
| Renton, KW; Turner, PV | 1 |
| Hilton-Brown, P; Svensson, JO; Tomson, T | 1 |
| Elyas, AA; Krishna, S; Lascelles, PT; Patsalos, PN; Stephenson, TJ; Wiles, CM | 1 |
| Macdonald, RL; McLean, MJ | 1 |
| Bennett, GD; Finnell, RH; Mohl, VK; Taylor, SM | 1 |
| Caccia, S; Conti, I; Fracasso, C; Salmona, M; Testa, R | 1 |
| Curzon, G; Lolin, YI; Patsalos, PN; Sokomba, EN | 1 |
| Holmes, MD; Narang, PK; Nice, FJ; Reeves, P; Theodore, WH | 1 |
| Landon, J; Sidki, AM; Smith, DS | 1 |
| Bertilsson, L; Fazio, A; Oteri, G; Perucca, E; Pisani, F; Spina, E | 1 |
| Bertilsson, L; Faigle, JW; Spina, E; Svensson, JO; Tomson, T | 1 |
| Brodie, MJ; Butler, E; Gillham, RA; Larkin, JG; Wiedmann, K; Williams, N | 1 |
| Bicz, W; Gaździk, W; Pachecka, J; Podleśny, J; Zaremba, K | 1 |
| Alavijeh, MS; Brownhill, W; Lascelles, PT; Patsalos, PN | 1 |
| Amione, C; Barzaghi, N; Crema, F; Faja, A; Gatti, G; Leone, L; Monteleone, M; Perucca, E | 1 |
| Chelberg, RD; Gunawan, S; Treiman, DM | 1 |
| Ivanyi, L; Zakrzewska, JM | 1 |
| Eichelbaum, M; Fröscher, W; Hildenbrand, G; Stoll, KD | 1 |
| Riad, LE; Sawchuk, RJ | 2 |
| Caccia, S; Conti, I; Guiso, G; Urso, R | 1 |
| Amione, C; Barzaghi, N; Crema, F; Gatti, G; Leone, L; Monteleone, M; Perucca, E | 1 |
| Neuvonen, PJ; Tokola, O | 1 |
| Kaneniwa, N; Sumi, M; Umezawa, O; Watari, N | 1 |
| Kaneniwa, N; Naito, H; Sumi, M; Umezawa, O; Watari, N | 1 |
| Post, RM; Weiss, SR | 1 |
| Davidson, AV; Davidson, DL; Hockings, N; Moody, J; Pall, A | 1 |
| Bellucci, G; Berti, G; Chiappe, C; Lippi, A; Marioni, F | 1 |
| Elyas, AA; Krishna, S; Lascelles, PT; Patsalos, PN | 1 |
| Asberg, A; Haffner, F | 1 |
| Berg, JD; Buckley, BM | 1 |
| Juergens, U; May, T; Rambeck, B | 1 |
| Friel, PN; van Belle, G | 1 |
| Agbato, OA; Brett, EM; Elyas, AA; Lascelles, PT; Patsalos, PN | 2 |
| Hekster, YA; Janssen, TJ; Termond, EF; van de Dries, AC; Vree, TB; Wijnands, WJ | 1 |
| Becker, M; Cookman, JR; Forsythe, WI; Hartley, R; Lucock, M; Smith, IJ; Smithells, RW | 1 |
| Di Perri, R; Fazio, A; Oteri, G; Perucca, E; Pisani, B; Pisani, F; Russo, M; Trio, R | 1 |
| McKinlay, I; Smith, I; Tomlin, PI | 1 |
| Albani, F; Baruzzi, A; Contin, M; Perucca, E; Riva, R | 1 |
| Rapeport, WG | 1 |
| Chang, SL; Levy, RH | 1 |
| Mendez-Alvarez, E; Sierra-Marcuño, G; Soto-Otero, R | 1 |
| Bonin, P; Casara, GL; Furlanut, M; Montanari, G | 1 |
| Dickinson, RG; Eadie, MJ; Hooper, WD; King, AR; Patterson, M | 1 |
| Berry, DJ; Bryson, SM; Denning, DW; Henry, JA; Matheson, L; Streete, J | 1 |
| Chan, KK; Gerardin, A; Hall, NR; LeSher, AR; Redalieu, E; Sawchuk, RJ; Thompson, TA; Wagner, WE; Weeks, BJ | 1 |
| Friel, PN; Miller, DQ; Yerby, MS | 1 |
| Casto, DT; Gal, P; Groce, JB | 1 |
| Albani, F; Ambrosetto, G; Baruzzi, A; Contin, M; Perucca, E; Procaccianti, G; Riva, R; Santucci, M | 1 |
| Chan, K | 1 |
| Albani, F; Baruzzi, A; Contin, M; Lamontanara, G; Perucca, E; Riva, R | 1 |
| Binnie, CD; de Beer-Pawlikowski, NK; Debets, RM; Meijer, JW; van Parys, JA | 1 |
| Post, RM; Uhde, TW; Wolff, EA | 1 |
| Dietrich, K; Eichelbaum, M; Froescher, W; Niesen, M; Rausch, P | 1 |
| Colin, L; Friel, PN; Johno, I; Koch, K; Levy, RH; Linthicum, LM; Raisys, VA; Temkin, NR; Wilensky, AJ | 1 |
| Brachet-Liermain, A; Guyot, M; Levy, RH; Loiseau, P; Moreland, TA; Morselli, PL | 1 |
| Brett, EM; Elyas, AA; Lascelles, PT; Schoeman, JF | 2 |
| Hoogewijs, G; Massart, DL | 1 |
| MacKichan, JJ; Zola, EM | 1 |
| Bourgeois, BF; Wad, N | 2 |
| Edwards, C; Panesar, R; Purkiss, R | 1 |
| Grasela, DM; Rocci, ML | 1 |
| de Groot, G; Maes, RA; van Heijst, AN | 1 |
| Edwards, C; Gard, PR; Rylance, GW | 1 |
| Albright, PS; Bruni, J | 1 |
| Albani, F; Ambrosetto, G; Baruzzi, A; Contin, M; Cortelli, P; Gobbi, G; Perucca, E; Procaccianti, G; Riva, R | 1 |
| Aman, MG; Paxton, JW; Werry, JS | 1 |
| Aucamp, AK; Hundt, HK; Müller, FO | 1 |
| Aucamp, AK; Hundt, HK; Müller, FO; Potgieter, MA | 1 |
| Andreasen, PB; Larsen, NE; Lühdorf, K; Sonne, J | 1 |
| Brodie, MJ; Forrest, G; Rapeport, WG | 1 |
| Deichl, A; Helge, H; Jäger-Roman, E; Kuhnz, W; Kunze, J; Nau, H; Rating, D | 1 |
| Kuhnz, W; Nau, H; Steldinger, R | 1 |
| Elyas, AA; Goldberg, VD; Lascelles, PT; Ratnaraj, N | 1 |
| Ballenger, JC; Bunney, WE; Chatterji, DC; Greene, RF; Post, RM; Uhde, TW | 1 |
| Bertilsson, L; Tomson, T; Tybring, G | 1 |
| Neels, HM; Scharpé, SL; Totté, JA; Verkerk, RM; Vlietinck, AJ | 1 |
| Meijer, JW; Rambeck, B; Riedmann, M | 1 |
| Bentley, P; Jung, R; Oesch, F | 1 |
| Paxton, JW | 1 |
| Cartier, LL; Sawchuk, RJ | 1 |
| Levy, RH; Patel, IH; Wedlund, PJ | 1 |
| Benassi, E; Besio, G; Ranise, A | 1 |
| Levy, RH; Patel, IH; Wedlund, P | 1 |
| Cohen, ME; Duffner, PK; MacKichan, JJ | 1 |
| Christiansen, J; Dam, M; Helles, A; Jaegerskou, A; Kristensen, CB; Schmiegelow, M | 1 |
| Brown, RD; Rane, A; van Boxtel, CJ; Wilson, JT | 1 |
| Angelo, H; Christensen, JM; Dam, M; Krag, B | 1 |
| MacKichan, JJ | 1 |
| Nad, N; Rosenmund, H; Weidkuhn, E | 1 |
| Delgado, MR; Liu, H | 3 |
| Fazio, A; Perucca, E; Pisani, F; Spina, E; Tomson, T; Xiao, B | 1 |
| Bonato, PS; Campos, GM; Lanchote, VL; Rodrigues, I | 1 |
| Jürgens, U; Lahl, R; May, T; Rambeck, B; Schnabel, R | 1 |
| Hannak, D; Haug, C; Korinthenberg, R | 1 |
| Fujii, I; Kodama, H; Kodama, Y; Kuranari, M; Okamoto, T; Takeyama, M; Tsutsumi, K; Yasunaga, F | 1 |
| Bernus, I; Dickinson, RG; Eadie, MJ; Hooper, WD | 2 |
| Baulac, M; Gimenez, F; Laplane, D; Longer, E; Semah, F; Thuillier, A | 1 |
| Barolome, M; Bernal, ML; Fanlo, A; Gazulla, J; Lanuza, J; Saenz, MA; Sinués, B | 1 |
| Gonzalez, FJ; Kerr, BM; Klein, SM; Kroetz, DL; Levy, RH; Thummel, KE; Wurden, CJ | 1 |
| Cramer, JA; During, MJ; Mattson, RH; Scheyer, RD; Spencer, DD | 1 |
| Jürgens, U; Lahl, R; May, TW; Rambeck, B; Schnabel, R | 1 |
| Banditt, P; Martens, J | 1 |
| Jones, SR; Ramachandran, S; Underhill, S | 1 |
| Ahmann, PA; Cascino, GD; Ruggles, KH; So, EL; Weatherford, KW | 1 |
| Camfield, CS; Camfield, PR; Dooley, JM; Fraser, AD; Gordon, KE | 1 |
| Guyot, M; Kroetz, DL; Levy, RH; Loiseau, P | 1 |
| Fujii, I; Kodama, H; Kodama, Y; Kuranari, M; Takeyama, M | 1 |
| Eugster, HP; Sengstag, C | 1 |
| Delgado, M; Eggers, CM; Forman, LJ; Iannaccone, ST; Liu, H | 1 |
| Anderson, GD; Gidal, BE; Miyoshi, HR; Seaton, TL; Wilenksy, AJ | 1 |
| Collins, DM; Gidal, BE; Pitterle, ME | 1 |
| Hagiwara, M; Kan, R; Takahashi, R; Takahashi, Y; Watabe, M | 1 |
| Dzeka, T; Ebinger, G; Michotte, Y; Sarre, S; Van Belle, K | 1 |
| McFadyen, ML; Miller, R; Moosa, RS; Rubin, J | 1 |
| Avenoso, A; Caputi, AP; Fazio, A; Pisani, F; Pollicino, AM; Spina, E | 1 |
| Frieman, M; Goldberg, SR; Marley, RJ; Shimosato, K | 1 |
| Lindhout, D; Los, FJ; Meijer, JW; Omtzigt, JG | 1 |
| Kerr, BM; Kroetz, DL; Levy, RH; Loiseau, P; McFarland, LV; Wilensky, AJ | 1 |
| Bye, A; Byron, D; Chee, KY; Lee, D; Naidoo, D | 1 |
| Graves, NM; Leppik, IE; Remmel, RP; Wagner, ML | 1 |
| Fujii, I; Kodama, H; Kodama, Y; Kuranari, M; Takeyama, M; Tsutsumi, K | 2 |
| Gidal, BE; Maly, MM; Pitterle, ME; Spencer, NW | 1 |
| Kimura, M; Maeoka, Y; Suzuki, N; Yoshino, K | 1 |
| Doose, DR; Kramer, LD; Nayak, RK; Sachdeo, RC; Sachdeo, SK; Walker, SA | 1 |
| Abbott, FS; Bandiera, SM; Panesar, SK | 1 |
| Davis, C; Howard, N; Kitteringham, NR; Park, BK; Pirmohamed, M | 1 |
| Fritsch, W; Jürgens, U; Lahl, R; May, T; Rambeck, B; Schnabel, R | 1 |
| Arnera, V; Castella, E; Chollet, D; Combe, P | 1 |
| Dial, SL; Grafton, TF; Hansen, DK; Terry, KK | 1 |
| Blacklaw, J; Brodie, MJ; Jamieson, V; Jones, T; Leach, JP; Richens, A | 1 |
| Pippenger, CE; Svinarov, DA | 1 |
| Amore, BM; Bennett, GD; Finnell, RH; Kalhorn, TF; Nelson, SD; Skiles, GL; Slattery, JT; Wlodarczyk, B | 1 |
| Arvela, P; Hakkola, J; Lampela, E; Pienimäki, P; Raunio, H; Vähäkangas, K | 1 |
| Nguyen, A; Ramzan, I | 1 |
| Brekelmans, GJ; Edelbroek, PM; Rademaker, RV; Saris, LA; van der Linden, GJ | 1 |
| Gidal, BE; Lensmeyer, GL; Wiebe, DA | 1 |
| Collins, DM; Gidal, BE; Maly, MM; Pitterle, ME; Rutecki, P; Shaw, R | 1 |
| Boreus, LO; Eriksson, AS | 1 |
| Guder, WG; Hallbach, J; Vogel, H | 1 |
| Chamberlin, N; Mahmood, I | 1 |
| Abe, K; Izumi, F; Minami, K; Terao, T; Toyohira, Y; Ueno, S; Uezono, Y; Yanagihara, N; Yoshimura, R | 1 |
| Bhatti, MM; Hanson, GD; Schultz, L | 1 |
| Berry, DJ; Besag, FM; Newbery, JE; Pool, F; Subel, B | 1 |
| Dutton, J; Higgins, G; Hughes, A; Roberts, NB | 1 |
| Härtter, S; Hiemke, C; Jensen, B; Leal, M; Unger, K; Weigmann, H | 1 |
| Donnelly, A; Potter, JM | 1 |
| Jürgens, U; May, T; Rambeck, B; Schnabel, R | 1 |
| Ersoy, O; Omurtag, GZ; Yeşilaltay, AK; Yurdun, T | 1 |
| Ohkubo, T; Shimoyama, R; Sugawara, K | 1 |
| Birkhahn, D; Burk, A; Dailey, JW; Graumlich, JF; Jobe, PC; McLaughlin, RG; Shah, N | 1 |
| Miura, H | 1 |
| Alfaro, RM; Burstein, AH; Dunn, T; Horton, RL; Piscitelli, SC; Theodore, W | 1 |
| Elin, RJ; Shen, S; Soldin, SJ | 1 |
| Getova, DP; Minkova, GD | 1 |
| Kuldvee, R; Thormann, W | 1 |
| Getova, D; Minkova, G | 1 |
| Badenhorst, D; Hundt, AF; Hundt, HK; Scanes, T; Swart, KJ; Van Rooyen, GF | 1 |
| Fujimoto, S; Kintsuji, S; Nagasawa, K; Nakanishi, H; Yamamoto, R | 1 |
| Fitzgerald, BJ; Okos, AJ | 1 |
| Szymańska, B; Szymczak, WM; Topaciński, B; Winnicka, RI | 1 |
| Koren, G | 1 |
| Bossu, H; Gagnieu, MC; Lardet, G; Moulsma, M; Parant, F | 1 |
| Ariyoshi, N; Ishii, I; Kitada, M; Nakamura, H; Nakasa, H; Ohmori, S; Torimoto, N | 1 |
| Chey, WY; Choi, J; Lee, AY | 1 |
| Hermida, J; Tutor, JC | 1 |
| Cohen, AF; Kroon, JM; Pieters, MS; Schoemaker, RC; van Gerven, JM; van Steveninck, AF | 1 |
| Cazali, N; d'Athis, P; Pons, G; Rey, E; Tran, A; Treluyer, JM; Vincent, J | 1 |
| Ariyoshi, N; Hata, M; Igarashi, T; Imada, H; Ishii, I; Kitada, M; Nakamura, H; Ohmori, S; Torimoto, N | 1 |
| Dasgupta, A; McNeese, C; Wells, A | 1 |
| Jiao, Z; Shi, XJ; Zhao, ZG; Zhong, MK | 1 |
| Agarwal, S; Aneja, S; Gupta, M; Gupta, YK; Kalaivani, M; Kohli, K | 1 |
| Dicenzo, R; DiFrancesco, R; Fischl, M; Forrest, A; Friedland, G; Morse, GD; Para, M; Pollard, R; Shelton, M; Smith, PF | 1 |
| Dasgupta, A; Datta, P | 1 |
| Fukushima-Uesaka, H; Goto, Y; Hasegawa, R; Kamatani, N; Kaniwa, N; Katoh, M; Kawai, M; Kimura, H; Minami, N; Nakajima, Y; Ohnuma, T; Ohtsuki, T; Ozawa, S; Saito, Y; Saitoh, O; Sawada, J; Shiseki, K; Sugai, K; Suzuki, C | 1 |
| Beutler, AS; Li, S; Nicol, R; Walsh, MJ | 1 |
| Kim, KA; Oh, SO; Park, JY; Park, PW | 1 |
| Bu, HZ; Deese, AJ; Kang, P; Pool, WF; Zhao, P | 1 |
| Hamano, S; Imai, K; Motohashi, S; Sato, M; Yoshida, T | 1 |
| Hemmateenejad, B; Khabnadideh, S; Rezaei, Z; Saffari, M | 1 |
| Bertucci, C; Chaves, AR; Dreossi, SA; Malfará, WR; Queiroz, ME; Queiroz, RH; Valério, DA | 1 |
| Damle, B; Grasela, DM; Ji, P; Kaul, S; Unger, SE; Xie, J | 1 |
| Culzoni, MJ; Goicoechea, HC; Olivieri, AC; Vera-Candioti, L | 1 |
| de Diego, M; Fierro, R; Godoy, CG; Mennickent, S; Vega, M | 1 |
| Jiang, XH; Jin, JX; Ju, Y; Liu, CX; Qiu, W | 1 |
| Dasgupta, A; Juenke, JM; McMillin, GA; Tso, G | 1 |
| Alves, G; Falcão, A; Fortuna, A; Soares-da-Silva, P; Sousa, J | 1 |
| Dasgupta, A; Davis, BG; Johnson, M; Marlow, AM; Reyes, MA | 1 |
| de Lannoy, I; Gien, B; Musteata, FM; Pawliszyn, J; Shirey, R; Sidisky, L; Vuckovic, D; Yang, Y | 1 |
| Galceran, MT; Huerta-Fontela, M; Ventura, F | 1 |
| Breton, H; Demoly, P; Gelisse, P; Hillaire-Buys, D; Mathieu, O; Picot, MC | 1 |
| Dasgupta, A; Johnson, MJ; Juenke, JM; McMillin, GA | 1 |
| Dhamodharan, J; Raja Karthik, K; Ram Prabahar, M; Singh, M; Singh, RB; Singh, S | 1 |
| Harder, JL; Heung, M; Mueller, BA; Segal, JH; Vilay, AM | 1 |
| Carton, A; Gatignol, C; Guerbet, M; Houeto, P; Lechat, P; Masset, D; Mauclaire, AC | 1 |
| Bakke, J; Gerna, M; Johannessen, SI; Morselli, PL; Strandjord, RE | 1 |
| Casellas, C; Fenet, H; Gomez, E; Hillaire-Buys, D; Li, Z; Mahjoub, O; Mathieu, O | 1 |
| Chi, YC; Hou, YC; Lin, SP | 1 |
| Ding, JJ; Jiao, Z; Wang, Y; Zhang, YJ | 1 |
| Lee, IO; MacLeod, BA; Puil, E; Ries, CR; Schwarz, SK; Whitehead, RA | 1 |
| Dang, XL; Liu, XY; Shi, L; Wei, HM; Yang, MM; Zhang, Y | 1 |
| Bořecká, K; Burianová, I | 1 |
| Boillot, C; Casellas, C; David, A; Fenet, H; Gomez, E; Le Dreau, M; Martinez Bueno, MJ; Mathieu, O; Munaron, D | 1 |
| de Almeida, CA; Mallmann, CA; Martins, AF; Oliveira, MS | 1 |
| Hýsková, V; Pomeislová, A; Pšondrová, Š; Ryšlavá, H; Smrček, S | 1 |
| Berg, AM; Meister, S; Mittag, N; Walther, UI | 1 |
| Bonnaillie, P; Chanteux, H; Rosa, M | 1 |
| Kearney, T; Petrie, MS; Smollin, CG | 1 |
| Brozmanova, H; Grundmann, M; Kacirova, I | 1 |
| Dasgupta, A; Davis, B; Johnson-Davis, KL; Slawson, MH | 1 |
| Fan, Y; Ma, K; Qu, L; Wang, W; Yin, Z | 1 |
| Golovko, O; Grabic, R; Klement, A; Koba, O; Kodešová, R | 1 |
| James, A; Lake, C; Patsalos, PN; Ratnaraj, N; Sander, JW; Zugman, M | 1 |
| Andres, S; Bado-Nilles, A; Baudoin, P; Beaudouin, R; Bonnard, I; Bonnard, M; Daniele, G; Fieu, M; Geffard, A; James-Casas, A; Joachim, S; Vulliet, E | 1 |
| Hanioka, N; Isobe, T; Miyata-Nozaka, Y; Shigeyama, M; Taguchi, M; Zain, SM | 1 |
| Bade-Döding, C; Blasczyk, R; Celik, AA; Hò, GT; Huyton, T; Kuhn, J; Kunze-Schumacher, H; Simper, GS | 1 |
| He, GH; Shen, ML; Wang, P; Xie, CX; Zhang, Z; Zhao, GX | 1 |
| Moseley, BD; Otoul, C; Staelens, L; Stockis, A | 1 |
| Bacher, M; Bernedo, V; Blickhan, M; Dietmann, D; Intravooth, T; Kornmeier, R; Kurth, C; Mahn, P; Schneider, M; Staack, AM; Steinhoff, BJ; Stockinger, J | 1 |
| Kuang, H; Liu, L; Xu, C; Xu, L; Zhou, S | 1 |
| Darweesh, RS; El-Elimat, T; Khamis, TN | 1 |
| Al-Qaim, FF; Mussa, ZH | 1 |
5 review(s) available for carbamazepine epoxide and carbamazepine
| Article | Year |
|---|---|
Kinetics, metabolism and effects of carbamazepine-10,11-epoxide in man.
Topics: Animals; Anticonvulsants; Carbamazepine; Drugs, Investigational; Electroencephalography; Evoked Potentials; Humans; Metabolic Clearance Rate | 1991 |
Factors influencing the relationship between carbamazepine plasma concentration and its clinical effects in patients with epilepsy.
Topics: Brain Chemistry; Carbamazepine; Drug Therapy, Combination; Epilepsies, Partial; Epilepsy; Epilepsy, Temporal Lobe; Humans; Kinetics | 1985 |
Potential interaction between carbamazepine and loxapine: case report and retrospective review.
Topics: Adult; Carbamazepine; Drug Interactions; Drug Monitoring; Female; Humans; Loxapine; Male; Middle Aged; Prospective Studies; Retrospective Studies | 1993 |
Successful treatment of carbamazepine poisoning with hemodialysis: a case report and review of the literature.
Topics: Adult; Analgesics, Non-Narcotic; Carbamazepine; Drug-Related Side Effects and Adverse Reactions; Female; Humans; Renal Dialysis; Time Factors | 2011 |
Association between EPHX1 polymorphisms and carbamazepine metabolism in epilepsy: a meta-analysis.
Topics: Anticonvulsants; Carbamazepine; Drug Resistance; Epilepsy; Epoxide Hydrolases; Humans; Polymorphism, Single Nucleotide | 2019 |
33 trial(s) available for carbamazepine epoxide and carbamazepine
| Article | Year |
|---|---|
A comparison of carbamazepine Divitabs and a normal carbamazepine preparation in psychiatric and oligophrenic patients.
Topics: Adult; Aged; Behavior; Carbamazepine; Delayed-Action Preparations; Double-Blind Method; Female; Humans; Male; Mental Disorders; Middle Aged; Seizures | 1992 |
Dissolution and relative bioavailability of two carbamazepine preparations for children with epilepsy.
Topics: Adolescent; Biological Availability; Carbamazepine; Child; Epilepsy; Female; Humans; Male; Random Allocation; Therapeutic Equivalency | 1991 |
Monotherapy with conventional and controlled-release carbamazepine: a double-blind, double-dummy comparison in epileptic patients.
Topics: Adult; Carbamazepine; Delayed-Action Preparations; Double-Blind Method; Drug Administration Schedule; Epilepsy; Female; Humans; Male; Middle Aged | 1991 |
Treatment of epilepsy in mentally retarded patients with a slow-release carbamazepine preparation.
Topics: Adolescent; Adult; Carbamazepine; Child; Delayed-Action Preparations; Double-Blind Method; Drug Administration Schedule; Electroencephalography; Epilepsy; Evoked Potentials; Female; Humans; Intellectual Disability; Male | 1991 |
Diurnal variation of carbamazepine and carbamazepine-10,11-epoxide in plasma and saliva in children with epilepsy: a comparison between conventional and slow-release formulations.
Topics: Adolescent; Carbamazepine; Child; Child, Preschool; Circadian Rhythm; Delayed-Action Preparations; Electroencephalography; Epilepsies, Partial; Epilepsy, Tonic-Clonic; Female; Follow-Up Studies; Humans; Male; Multicenter Studies as Topic | 1990 |
Inhibition by erythromycin of the conversion of carbamazepine to its active 10,11-epoxide metabolite.
Topics: Adult; Biotransformation; Carbamazepine; Depression, Chemical; Erythromycin; Humans; Male | 1987 |
Bioavailability of rectally administered carbamazepine mixture.
Topics: Administration, Rectal; Adult; Biological Availability; Carbamazepine; Chromatography, High Pressure Liquid; Female; Humans; Random Allocation | 1987 |
The effects of age on carbamazepine pharmacokinetics and adverse effects.
Topics: Adult; Aged; Aging; Carbamazepine; Double-Blind Method; Female; Humans; Kinetics; Male; Psychomotor Performance; Random Allocation; Saliva | 1986 |
Bioequivalence of carbamazepine chewable and conventional tablets: single-dose and steady-state studies.
Topics: Adult; Biotransformation; Carbamazepine; Humans; Kinetics; Tablets; Therapeutic Equivalency | 1985 |
Profile of clinical efficacy and side effect of carbamazepine in psychiatric illness: relationship to blood and CSF levels of carbamazepine and its -10,11-epoxide metabolite.
Topics: Biotransformation; Bipolar Disorder; Carbamazepine; Clinical Trials as Topic; Depressive Disorder; Double-Blind Method; Epilepsy, Temporal Lobe; Humans; Limbic System; Psychotic Disorders; Schizophrenia | 1984 |
Carbamazepine: a clinical biopharmaceutical study.
Topics: Adult; Carbamazepine; Female; Humans; Intestinal Absorption; Male; Particle Size; Solubility | 1981 |
Factors influencing plasma concentrations of carbamazepine and carbamazepine-10,11-epoxide in epileptic children and adults.
Topics: Adolescent; Adult; Aging; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Chromatography, High Pressure Liquid; Drug Interactions; Epilepsy; Female; Humans; Infant; Male; Middle Aged | 1995 |
The metabolization of carbamazepine to CBZ-10,11-epoxide in children from the newborn age to adolescence.
Topics: Adolescent; Age Factors; Anticonvulsants; Carbamazepine; Child; Child Development; Child, Preschool; Delayed-Action Preparations; Dose-Response Relationship, Drug; Drug Therapy, Combination; Epilepsies, Partial; Epilepsy, Complex Partial; Epilepsy, Tonic-Clonic; Female; Humans; Infant; Infant, Newborn; Male | 1994 |
Influence of sex, age, weight, and carbamazepine dose on serum concentrations, concentration ratios, and level/dose ratios of carbamazepine and its metabolites.
Topics: Aging; Body Weight; Carbamazepine; Child; Child, Preschool; Dose-Response Relationship, Drug; Epilepsy; Female; Humans; Male; Sex Factors | 1994 |
Carbamazepine and its epoxide: an open study of efficacy and side effects after carbamazepine dose increment in refractory partial epilepsy.
Topics: Adolescent; Adult; Aged; Carbamazepine; Drug Therapy, Combination; Epilepsies, Partial; Female; Humans; Male; Middle Aged; Remission Induction; Time Factors | 1994 |
Carbamazepine coadministration with fluoxetine or fluvoxamine.
Topics: Adult; Carbamazepine; Depression; Drug Interactions; Drug Therapy, Combination; Epilepsy, Complex Partial; Epilepsy, Tonic-Clonic; Female; Fluoxetine; Fluvoxamine; Humans; Male; Middle Aged | 1993 |
Effect of felbamate on carbamazepine and its major metabolites.
Topics: Adolescent; Adult; Anticonvulsants; Carbamazepine; Double-Blind Method; Drug Interactions; Epilepsy; Felbamate; Female; Humans; Male; Middle Aged; Phenylcarbamates; Phenytoin; Propylene Glycols | 1993 |
Steady-state pharmacokinetics of topiramate and carbamazepine in patients with epilepsy during monotherapy and concomitant therapy.
Topics: Adult; Anticonvulsants; Biological Availability; Carbamazepine; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Interactions; Drug Therapy, Combination; Epilepsies, Partial; Female; Fructose; Humans; Male; Metabolic Clearance Rate; Topiramate; Treatment Outcome | 1996 |
Mutual interaction between remacemide hydrochloride and carbamazepine: two drugs with active metabolites.
Topics: Acetamides; Adult; Anticonvulsants; Carbamazepine; Cross-Over Studies; Double-Blind Method; Drug Interactions; Epilepsy; Female; Humans; Male; Middle Aged; Placebos | 1996 |
Relationships between carbamazepine-diol, carbamazepine-epoxide, and carbamazepine total and free steady-state concentrations in epileptic patients: the influence of age, sex, and comedication.
Topics: Adolescent; Adult; Age Factors; Aged; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Drug Interactions; Drug Monitoring; Drug Therapy, Combination; Epilepsy; Female; Humans; Infant; Male; Middle Aged; Phenobarbital; Protein Binding; Sex Factors | 1996 |
The mechanism of the carbamazepine-valproate interaction in humans.
Topics: Adult; Anticonvulsants; Carbamazepine; Drug Therapy, Combination; Epilepsy; Female; Humans; Male; Middle Aged; Valproic Acid | 1997 |
A limited sampling method for the estimation of AUC and Cmax of carbamazepine and carbamazepine epoxide following a single and multiple dose of a sustained-release product.
Topics: Administration, Oral; Anticonvulsants; Area Under Curve; Carbamazepine; Delayed-Action Preparations; Dose-Response Relationship, Drug; Half-Life; Humans; Male | 1998 |
Micellar electrokinetic capillary chromatography for therapeutic drug monitoring of carbamazepine and its main metabolites.
Topics: Anticonvulsants; Carbamazepine; Chromatography, High Pressure Liquid; Drug Monitoring; Electrophoresis, Capillary; Humans | 1998 |
Developmental and therapeutic pharmacology of antiepileptic drugs.
Topics: Adolescent; Adult; Age Factors; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Drug Administration Schedule; Drug Industry; Drug Interactions; Drug Monitoring; Drug Therapy, Combination; Epilepsies, Partial; Epilepsy; Half-Life; Humans; Infant; Intestinal Absorption; Isoxazoles; Lamotrigine; Prospective Studies; Treatment Outcome; Triazines; Valproic Acid; Zonisamide | 2000 |
Influence of carbamazepine-10,11-epoxide on the serum level of valproic acid in epileptic patients on combined treatment with carbamazepine and valproic acid.
Topics: Adolescent; Adult; Age Factors; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Drug Interactions; Drug Therapy, Combination; Epilepsy; Humans; Middle Aged; Valproic Acid | 2000 |
The psychomotor effects of carbamazepine in epileptic patients and healthy volunteers.
Topics: Adolescent; Adult; Anticonvulsants; Area Under Curve; Carbamazepine; Chromatography, High Pressure Liquid; Epilepsy; Female; Humans; Male; Middle Aged; Psychomotor Performance; Pursuit, Smooth; Saccades; Time Factors | 2003 |
Effects of add-on melatonin administration on antioxidant enzymes in children with epilepsy taking carbamazepine monotherapy: a randomized, double-blind, placebo-controlled trial.
Topics: Anticonvulsants; Antioxidants; Carbamazepine; Child; Child, Preschool; Double-Blind Method; Drug Interactions; Drug Therapy, Combination; Epilepsy; Female; Glutathione Peroxidase; Glutathione Reductase; Humans; Male; Melatonin; Oxidative Stress; Placebos; Treatment Outcome | 2004 |
Population pharmacokinetics of delavirdine and N-delavirdine in HIV-infected individuals.
Topics: Adolescent; Adult; Anti-HIV Agents; Body Weight; Carbamazepine; Delavirdine; Double-Blind Method; Drug Therapy, Combination; Female; HIV Infections; Humans; Male; Metabolic Clearance Rate; Middle Aged; Racial Groups; Sex Factors | 2005 |
Haplotype structures of EPHX1 and their effects on the metabolism of carbamazepine-10,11-epoxide in Japanese epileptic patients.
Topics: Adolescent; Adult; Aged; Carbamazepine; Child; Epilepsy; Epoxide Hydrolases; Female; Haplotypes; Humans; Japan; Male; Middle Aged; Pharmacogenetics; Polymerase Chain Reaction; Polymorphism, Genetic | 2005 |
Effect of probenecid on the pharmacokinetics of carbamazepine in healthy subjects.
Topics: Adult; Anticonvulsants; Area Under Curve; Aryl Hydrocarbon Hydroxylases; Carbamazepine; Cross-Over Studies; Cytochrome P-450 CYP2C8; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Drug Interactions; Female; Glucuronides; Glucuronosyltransferase; Half-Life; Humans; Korea; Male; Metabolic Clearance Rate; Probenecid; Time Factors; Uricosuric Agents | 2005 |
Pharmacokinetic interaction between efavirenz and carbamazepine after multiple-dose administration in healthy subjects.
Topics: Adult; Alkynes; Anti-HIV Agents; Anticonvulsants; Area Under Curve; Benzoxazines; Biotransformation; Carbamazepine; Chromatography, High Pressure Liquid; Cross-Over Studies; Cyclopropanes; Drug Interactions; Female; Half-Life; Humans; Male; Middle Aged; Sample Size | 2008 |
Effects of carbamazepine and metabolites on IL-2, IL-5, IL-6, IL-10 and IFN-γ secretion in epileptic patients: the influence of co-medication.
Topics: Acridines; Adult; Aged; Anticonvulsants; Carbamazepine; Dibenzazepines; Drug Therapy, Combination; Epilepsy; Female; Humans; Interferon-gamma; Interleukins; Lamotrigine; Male; Middle Aged; Th1 Cells; Th2 Cells; Triazines; Valproic Acid; Young Adult | 2011 |
Pharmacokinetic interaction of brivaracetam on other antiepileptic drugs in adults with focal seizures: Pooled analysis of data from randomized clinical trials.
Topics: Adult; Anticonvulsants; Carbamazepine; Drug Resistant Epilepsy; Epilepsies, Partial; Female; Humans; Male; Middle Aged; Pyrrolidinones; Seizures | 2019 |
249 other study(ies) available for carbamazepine epoxide and carbamazepine
| Article | Year |
|---|---|
Computation of brain-blood partitioning of organic solutes via free energy calculations.
Topics: Animals; Blood-Brain Barrier; Brain; Cattle; Cells, Cultured; Endothelium, Vascular; Membrane Lipids; Microcirculation; Molecular Conformation; Molecular Structure; Monte Carlo Method; Permeability; Pharmaceutical Preparations; Software; Solubility; Thermodynamics | 1996 |
Carbamazepine derivatives with P2X4 receptor-blocking activity.
Topics: Adenosine Triphosphate; Animals; Calcium; Carbamazepine; Chemistry Techniques, Synthetic; Dibenzazepines; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Humans; Inhibitory Concentration 50; Mice; Purinergic P2X Receptor Antagonists; Rats; Receptors, Purinergic P2X4; Structure-Activity Relationship | 2014 |
The epoxide of carbamazepine.
Topics: Adolescent; Adult; Aged; Anticonvulsants; Biotransformation; Carbamazepine; Child; Child, Preschool; Epilepsy; Female; Humans; Infant; Male; Methods; Middle Aged; Phenytoin | 1979 |
Rapid quantitative method for the simultaneous determination of carbamazepine, carbamazepine-10,11-epoxide, diphenylhydantion, mephenytoin, phenobarbital and primidone in serum by thin-layer chromatography.
Topics: Carbamazepine; Chromatography, Thin Layer; Drug Combinations; Epoxy Compounds; Humans; Hydantoins; Mephenytoin; Phenobarbital; Phenytoin; Primidone | 1978 |
Impairment of carbamazepine-10, 11-epoxide elimination by valnoctamide, a valpromide isomer, in healthy subjects.
Topics: Administration, Oral; Adult; Amides; Anti-Anxiety Agents; Carbamazepine; Drug Interactions; Female; Half-Life; Humans; Male; Middle Aged | 1992 |
Autoinduction and steady-state pharmacokinetics of carbamazepine and its major metabolites.
Topics: Adult; Carbamazepine; Female; Humans; Male; Middle Aged | 1992 |
Distribution of carbamazepine and its epoxide in blood compartments in adolescent and adult epileptic patients.
Topics: Adolescent; Adult; Aged; Aging; Blood Proteins; Carbamazepine; Chromatography, High Pressure Liquid; Epilepsy; Erythrocytes; Humans; Middle Aged; Ultrafiltration | 1992 |
Variability and clinical relevance of the interaction between sodium valproate and carbamazepine in epileptic patients.
Topics: Adolescent; Adult; Carbamazepine; Cognition; Drug Interactions; Epilepsy; Female; Humans; Male; Middle Aged; Valproic Acid | 1992 |
Direct injection analysis of carbamazepine and its active 10,11-epoxide metabolite in plasma by use of a semipermeable surface (SPS) silica column in LC.
Topics: Calibration; Carbamazepine; Chromatography, High Pressure Liquid; Flow Injection Analysis; Humans; Hydrogen-Ion Concentration | 1992 |
Automated microanalysis of carbamazepine and its epoxide and trans-diol metabolites in plasma by column liquid chromatography.
Topics: Autoanalysis; Carbamazepine; Chromatography, Liquid; Humans; Indicators and Reagents; Microchemistry; Specimen Handling; Spectrophotometry, Ultraviolet | 1992 |
Antiepileptic drugs and teratogenesis in two consecutive cohorts: changes in prescription policy paralleled by changes in pattern of malformations.
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Carbamazepine; Cohort Studies; Drug Prescriptions; Epilepsy; Female; Humans; Infant; Infant, Newborn; Male; Phenobarbital; Phenytoin; Pregnancy; Pregnancy Complications; Valproic Acid | 1992 |
An investigation of the formation of cytotoxic, protein-reactive and stable metabolites from carbamazepine in vitro.
Topics: Animals; Ascorbic Acid; Biotransformation; Carbamazepine; Cell Death; Cytosol; Epoxide Hydrolases; Glutathione; Humans; Ketoconazole; Lymphocytes; Mice; Microsomes, Liver; Models, Chemical; Phenobarbital; Proteins | 1992 |
Performance of techniques for measurement of therapeutic drugs in serum. A comparison based on external quality assessment data.
Topics: Carbamazepine; Fluorescence Polarization Immunoassay; Humans; Pharmaceutical Preparations; Quality Control | 1992 |
Lamotrigine-induced carbamazepine toxicity: an interaction with carbamazepine-10,11-epoxide.
Topics: Adult; Anticonvulsants; Carbamazepine; Chromatography, High Pressure Liquid; Drug Interactions; Drug Therapy, Combination; Female; Humans; Lamotrigine; Male; Radioimmunoassay; Triazines | 1992 |
The pharmacology of chewable versus regular carbamazepine in chronically treated children with epilepsy.
Topics: Carbamazepine; Child; Chronic Disease; Epilepsy; Female; Humans; Male; Tablets | 1992 |
Influence of concurrent administration of sodium valproate on the plasma concentrations of carbamazepine and its epoxide and diol metabolites.
Topics: Adolescent; Adult; Carbamazepine; Child; Child, Preschool; Drug Therapy, Combination; Epilepsy; Female; Humans; Male; Valproic Acid | 1991 |
Carbamazepine and its 10,11-epoxide metabolite in acute mania: clinical and pharmacokinetic correlates.
Topics: Acute Disease; Adolescent; Adult; Aged; Bipolar Disorder; Carbamazepine; Female; Humans; Male; Middle Aged; Saliva | 1991 |
Analysis of carbamazepine and its 10,11-epoxide in serum by direct sample injection using surfactant containing eluents and column switching.
Topics: Carbamazepine; Chromatography, Liquid; Drug Monitoring; Humans; Reproducibility of Results; Surface-Active Agents | 1991 |
Analysis of drugs in the presence of serum albumin by liquid chromatography with eluents containing surfactants.
Topics: Adsorption; Carbamazepine; Chromatography, Liquid; Hydrogen-Ion Concentration; Serum Albumin; Surface-Active Agents; Xanthines | 1991 |
Increased carbamazepine plasma concentrations after fluoxetine coadministration.
Topics: Administration, Oral; Adult; Carbamazepine; Chromatography, High Pressure Liquid; Drug Interactions; Fluoxetine; Humans; Male | 1991 |
Determination of the relative formation and elimination clearance of two major carbamazepine metabolites in humans: a comparison between traditional and pooled sample analysis.
Topics: Administration, Oral; Adult; Carbamazepine; Humans; Male; Models, Biological | 1991 |
Heterologous expression of human microsomal epoxide hydrolase in Saccharomyces cerevisiae. Study of the valpromide-carbamazepine epoxide interaction.
Topics: Base Sequence; Carbamazepine; Drug Interactions; Epoxide Hydrolases; Epoxy Compounds; Gene Expression Regulation, Enzymologic; Humans; Kinetics; Microsomes; Molecular Sequence Data; Saccharomyces cerevisiae; Styrenes; Valproic Acid | 1991 |
Daily variations in steady-state plasma concentrations of carbamazepine and its metabolites in epileptic children.
Topics: Adolescent; Carbamazepine; Child; Chromatography, High Pressure Liquid; Epilepsy; Female; Humans; Male | 1991 |
Effect of phenobarbital on the pharmacokinetics of carbamazepine-10,11-epoxide, an active metabolite of carbamazepine.
Topics: Adult; Biological Availability; Carbamazepine; Drug Interactions; Epilepsy; Humans; Male; Middle Aged; Phenobarbital | 1991 |
Analysis of carbamazepine in serum by liquid chromatography with direct sample injection and surfactant-containing eluents.
Topics: Animals; Carbamazepine; Cattle; Chromatography, Liquid; Hydrogen-Ion Concentration | 1990 |
Valproic acid-induced carbamazepine-10,11-epoxide toxicity in children and adolescents.
Topics: Adolescent; Adult; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Drug Interactions; Epilepsy; Female; Humans; Infant; Male; Valproic Acid | 1990 |
Carbamazepine metabolism in humans: effect of concurrent anticonvulsant therapy.
Topics: Administration, Oral; Adolescent; Adult; Carbamazepine; Chromatography, High Pressure Liquid; Drug Interactions; Drug Therapy, Combination; Epilepsy; Female; Half-Life; Humans; Male; Middle Aged; Phenobarbital; Phenytoin; Protein Binding; Valproic Acid | 1990 |
Inhibition of epoxide hydrolase by valproic acid in epileptic patients receiving carbamazepine.
Topics: Adolescent; Blood Proteins; Carbamazepine; Child; Epilepsy; Epoxide Hydrolases; Female; Humans; Male; Protein Binding; Valproic Acid | 1990 |
Inhibitory effect of valproic acid on metabolic clearance of carbamazepine epoxide.
Topics: Animals; Arabidopsis Proteins; Carbamazepine; Glucosyltransferases; Male; Rats; Rats, Inbred Strains; Time Factors; Valproic Acid | 1990 |
Carbamazepine drug interactions: the influence of concurrent drug therapy on serum concentrations of carbamazepine and its epoxide metabolite.
Topics: Adolescent; Adult; Anticonvulsants; Carbamazepine; Drug Interactions; Drug Therapy, Combination; Epilepsy; Female; Humans; Male; Middle Aged; Regression Analysis | 1990 |
A simple and disposable visual measuring device to assay antiepileptic drugs from whole blood samples.
Topics: Anticonvulsants; Carbamazepine; Chromatography; Humans; Immunoenzyme Techniques; Phenobarbital; Phenytoin | 1990 |
Postmortem serum protein binding and brain concentrations of antiepileptic drugs in autoptic specimens from 45 epileptic patients.
Topics: Anticonvulsants; Blood Proteins; Brain; Carbamazepine; Epilepsy; Female; Humans; Male; Phenobarbital; Phenytoin; Protein Binding; Valproic Acid | 1990 |
Factors influencing plasma level/dose ratios of carbamazepine and its major metabolites in epileptic children.
Topics: Adolescent; Age Factors; Carbamazepine; Child; Epilepsy; Humans; Regression Analysis; Time Factors | 1990 |
No effect of thioridazine on plasma concentrations of carbamazepine and its active metabolite carbamazepine-10,11-epoxide.
Topics: Adult; Carbamazepine; Epilepsy; Female; Homeostasis; Humans; Male; Middle Aged; Thioridazine | 1990 |
Simultaneous assay of felbamate plus carbamazepine, phenytoin, and their metabolites by liquid chromatography with mobile phase optimization.
Topics: Carbamazepine; Chromatography, High Pressure Liquid; Felbamate; Humans; Phenylcarbamates; Phenytoin; Propylene Glycols | 1990 |
Effect of ponsinomycin on single-dose kinetics and metabolism of carbamazepine.
Topics: Adult; Blood Proteins; Carbamazepine; Drug Interactions; Female; Humans; Male; Miocamycin; Protein Binding | 1990 |
A comparative pharmacokinetic study of conventional and chewable carbamazepine in epileptic patients.
Topics: Adult; Biological Availability; Carbamazepine; Epilepsy; Female; Humans; Male; Tablets | 1990 |
Dose-dependent pharmacokinetics of carbamazepine in rats: determination of the formation clearance of carbamazepine-10,11-epoxide.
Topics: Animals; Blood Proteins; Carbamazepine; Dose-Response Relationship, Drug; Injections, Intravenous; Male; Protein Binding; Rats; Rats, Inbred Strains; Regression Analysis | 1990 |
Carbamazepine-10,11-epoxide in epilepsy. A pilot study.
Topics: Adult; Carbamazepine; Dose-Response Relationship, Drug; Epilepsy; Female; Humans; Male; Middle Aged; Neuropsychological Tests; Pilot Projects; Single-Blind Method | 1990 |
The effect of clobazam on steady state plasma concentrations of carbamazepine and its metabolites.
Topics: Anti-Anxiety Agents; Anticonvulsants; Benzodiazepines; Benzodiazepinones; Carbamazepine; Chromatography, High Pressure Liquid; Clobazam; Drug Therapy, Combination; Epilepsy; Humans | 1990 |
Carbamazepine and carbamazepine-epoxide serum concentrations in some resistant cases of complex partial seizures.
Topics: Adolescent; Adult; Carbamazepine; Dose-Response Relationship, Drug; Epilepsies, Partial; Female; Humans; Male | 1989 |
Inhibition of human liver microsomal epoxide hydrolase by valproate and valpromide: in vitro/in vivo correlation.
Topics: Anticonvulsants; Carbamazepine; Drug Interactions; Epoxide Hydrolases; Epoxy Compounds; Humans; Hydrolysis; In Vitro Techniques; Male; Microsomes, Liver; Valproic Acid | 1989 |
Carbamazepine update.
Topics: Carbamazepine; Diuresis; Drug Evaluation; Drug Interactions; Epilepsy; Humans; Trigeminal Neuralgia | 1989 |
Simultaneous quantitation of salivary carbamazepine, carbamazepine-10,11-epoxide, phenytoin and phenobarbitone by high-performance liquid chromatography.
Topics: Anticonvulsants; Carbamazepine; Chromatography, High Pressure Liquid; Humans; Phenobarbital; Phenytoin; Saliva; Spectrophotometry, Ultraviolet | 1989 |
[Simultaneous determination of carbamazepine and its active metabolite in serum by high performance liquid chromatography].
Topics: Carbamazepine; Chromatography, High Pressure Liquid; Humans | 1989 |
Evaluation of an enzyme immunochromatography method for carbamazepine: a comparison with enzyme-multiplied immunoassay technique, fluorescence polarization immunoassay, and high-performance liquid chromatography.
Topics: Adolescent; Adult; Aged; Carbamazepine; Child; Chromatography, High Pressure Liquid; Enzyme-Linked Immunosorbent Assay; Evaluation Studies as Topic; Fluorescent Antibody Technique; Humans; Middle Aged; Spectrometry, Fluorescence | 1989 |
Amygdala-kindling as a model for chronic efficacy studies on antiepileptic drugs: experiments with carbamazepine.
Topics: Amygdala; Animals; Anticonvulsants; Body Temperature; Body Weight; Carbamazepine; Electric Stimulation; Electrodes, Implanted; Female; Kindling, Neurologic; Models, Neurological; Rats; Rats, Inbred Strains; Substance Withdrawal Syndrome | 1989 |
Application of thermospray liquid chromatography-mass spectrometry to the simultaneous quantification of tracer concentrations of isotopically labelled carbamazepine epoxide and steady-state levels of carbamazepine and carbamazepine epoxide.
Topics: Carbamazepine; Chemical Phenomena; Chemistry; Chromatography, High Pressure Liquid; Humans; Isotopes; Mass Spectrometry | 1989 |
The interaction between carbamazepine and erythromycin.
Topics: Animals; Carbamazepine; Drug Interactions; Erythromycin; Female; Half-Life; In Vitro Techniques; Male; Microsomes, Liver; Rats; Rats, Inbred Strains; Swine | 1989 |
Relationship of intraindividual dose to plasma concentration of carbamazepine: indication of dose-dependent induction of metabolism.
Topics: Adolescent; Adult; Carbamazepine; Dose-Response Relationship, Drug; Epilepsy; Female; Humans; Male | 1989 |
Side-effects induced by carbamazepine-10,11-epoxide.
Topics: Carbamazepine; Female; Humans; Middle Aged | 1985 |
Carbamazepine and 10,11-epoxycarbamazepine produce use- and voltage-dependent limitation of rapidly firing action potentials of mouse central neurons in cell culture.
Topics: Action Potentials; Animals; Carbamazepine; Cells, Cultured; Central Nervous System; Cerebral Cortex; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Hippocampus; Membrane Potentials; Mice; Neurons; Phenytoin; Sodium; Spinal Cord | 1986 |
Failure of epoxide formation to influence carbamazepine-induced teratogenesis in a mouse model.
Topics: Animals; Carbamazepine; Female; Fetal Blood; Fetal Growth Retardation; Mice; Mice, Inbred Strains; Pregnancy; Species Specificity; Teratogens | 1986 |
Interaction of the anticonvulsants, denzimol and nafimidone, with liver cytochrome P450 in the rat.
Topics: Animals; Anticonvulsants; Biotransformation; Carbamazepine; Cytochrome P-450 Enzyme System; Diazepam; Imidazoles; In Vitro Techniques; Liver; Male; Microsomes, Liver; Naphazoline; Rats; Rats, Inbred Strains; Sleep; Time Factors | 1988 |
Concurrent monitoring of central carbamazepine and transmitter amine metabolism and motor activity in individual unrestrained rats using repetitive withdrawal of cerebrospinal fluid.
Topics: Animals; Brain Chemistry; Carbamazepine; Kinetics; Male; Motor Activity; Neurotransmitter Agents; Rats; Rats, Inbred Strains | 1988 |
Carbamazepine and its epoxide: relation of plasma levels to toxicity and seizure control.
Topics: Carbamazepine; Dose-Response Relationship, Drug; Drug Therapy, Combination; Electroencephalography; Epilepsy, Temporal Lobe; Evoked Potentials; Humans | 1989 |
Direct homogeneous phosphoroimmunoassay for carbamazepine in serum.
Topics: Carbamazepine; Chromatography, High Pressure Liquid; Erythrosine; Humans; Immunoassay; Luminescent Measurements; Temperature | 1986 |
Effect of valpromide on the pharmacokinetics of carbamazepine-10, 11-epoxide.
Topics: Adolescent; Adult; Anticonvulsants; Carbamazepine; Female; Half-Life; Humans; Male; Middle Aged; Valproic Acid | 1988 |
Single-dose kinetics of an enteric-coated formulation of carbamazepine-10,11-epoxide, an active metabolite of carbamazepine.
Topics: Adult; Carbamazepine; Female; Half-Life; Humans; Male; Tablets, Enteric-Coated | 1988 |
Concentration-effect relationships with carbamazepine and its epoxide on psychomotor and cognitive function in epileptic patients.
Topics: Adult; Carbamazepine; Dose-Response Relationship, Drug; Drug Therapy, Combination; Epilepsy; Female; Humans; Male; Neuropsychological Tests; Psychomotor Performance; Substance-Related Disorders | 1988 |
Effect of high ambient temperature on distribution of carbamazepine and its main metabolite 10,11-epoxy-carbamazepine in rat brain.
Topics: Animals; Biological Transport; Brain; Carbamazepine; Hot Temperature; Male; Rats; Time Factors | 1988 |
Effect of denzimol on carbamazepine and carbamazepine-10,11-epoxide concentrations in serum, liver, spleen and different brain regions of the rat: an inhibitory metabolic interaction.
Topics: Animals; Anticonvulsants; Brain; Carbamazepine; Drug Interactions; Imidazoles; Liver; Male; Rats; Rats, Inbred Strains; Spleen | 1988 |
Effect of flurithromycin, a new macrolide antibiotic, on carbamazepine disposition in normal subjects.
Topics: Adult; Carbamazepine; Erythromycin; Half-Life; Humans; Male | 1988 |
Simultaneous high-performance liquid chromatographic determination of carbamazepine and its principal metabolites in human plasma and urine.
Topics: Biotransformation; Carbamazepine; Chromatography, High Pressure Liquid; Humans | 1988 |
In vitro lymphocyte proliferation by carbamazepine, carbamazepine-10, 11-epoxide, and oxcarbazepine in the diagnosis of drug-induced hypersensitivity.
Topics: Administration, Oral; Anticonvulsants; Carbamazepine; Drug Hypersensitivity; Humans; Lymphocyte Activation; Oxcarbazepine; Trigeminal Neuralgia | 1988 |
Investigations on the intraindividual constancy of the ratio of carbamazepine to carbamazepine-10,11-epoxide in man.
Topics: Adolescent; Adult; Carbamazepine; Chromatography, High Pressure Liquid; Female; Humans; Male; Middle Aged; Sex Factors | 1988 |
Simultaneous determination of carbamazepine and its epoxide and transdiol metabolites in plasma by microbore liquid chromatography.
Topics: Adult; Carbamazepine; Chromatography, Liquid; Clonazepam; Humans; Male; Phenobarbital; Phenytoin; Quality Control; Statistics as Topic; Therapeutic Equivalency | 1988 |
Inhibitory and inducing effects of denzimol on carbamazepine metabolism in the rat.
Topics: Animals; Anticonvulsants; Body Weight; Carbamazepine; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Enzyme Induction; Imidazoles; In Vitro Techniques; Male; Microsomes, Liver; Organ Size; Rats | 1987 |
Pharmacokinetic study of carbamazepine and its epoxide metabolite in humans.
Topics: Adult; Biological Availability; Biotransformation; Carbamazepine; Female; Humans; Male | 1987 |
[Influence of phenobarbital on pharmacokinetics of carbamazepine and its epoxide metabolite in the rabbit].
Topics: Animals; Carbamazepine; Male; Models, Biological; Phenobarbital; Rabbits | 1987 |
Carbamazepine and carbamazepine-10,11-epoxide inhibit amygdala-kindled seizures in the rat but do not block their development.
Topics: Amygdala; Animals; Carbamazepine; Kindling, Neurologic; Male; Rats; Rats, Inbred Strains; Seizures | 1987 |
The metabolism of carbamazepine in humans: steric course of the enzymatic hydrolysis of the 10,11-epoxide.
Topics: Adult; Animals; Carbamazepine; Circular Dichroism; Cytosol; Epoxide Hydrolases; Female; Guinea Pigs; Humans; Hydrolysis; Liver; Magnetic Resonance Spectroscopy; Male; Microsomes, Liver; Molecular Conformation; Rabbits; Rats; Rats, Inbred Strains | 1987 |
Carbamazepine and carbamazepine-10,11-epoxide pharmacokinetics in an overdose patient.
Topics: Adolescent; Carbamazepine; Female; Half-Life; Humans; Kinetics; Nervous System Diseases | 1987 |
Analysis of serum concentration of phenobarbital, phenytoin, carbamazepine and carbamazepine 10,11-epoxide by solvent-recycled liquid chromatography.
Topics: Carbamazepine; Chromatography, High Pressure Liquid; Humans; Phenobarbital; Phenytoin | 1987 |
Rapid measurement of anticonvulsant drug concentrations in the out-patient clinic, using HPLC with direct injection of plasma.
Topics: Carbamazepine; Chromatography, High Pressure Liquid; Evaluation Studies as Topic; Humans; Phenobarbital; Phenytoin | 1987 |
Serum concentrations of carbamazepine and its epoxide and diol metabolites in epileptic patients: the influence of dose and comedication.
Topics: Adult; Carbamazepine; Dose-Response Relationship, Drug; Drug Interactions; Drug Therapy, Combination; Epilepsy; Female; Humans; Male; Middle Aged; Regression Analysis | 1987 |
Problem of spurious correlation in the evaluation of steady-state carbamazepine levels using metabolite data.
Topics: Adolescent; Adult; Anticonvulsants; Carbamazepine; Drug Therapy, Combination; Epilepsy; Female; Humans; Male; Middle Aged; Statistics as Topic | 1986 |
Factors influencing simultaneous concentrations of total and free carbamazepine and carbamazepine-10, 11-epoxide in serum of children with epilepsy.
Topics: Adolescent; Adult; Age Factors; Carbamazepine; Child; Child, Preschool; Dose-Response Relationship, Drug; Drug Therapy, Combination; Epilepsy; Female; Free Radicals; Humans; Male | 1986 |
Clinical pharmacokinetics of carbamazepine and its epoxy and hydroxy metabolites in humans after an overdose.
Topics: Adult; Carbamazepine; Female; Humans; Hydrolysis; Kidney; Kinetics; Male; Middle Aged; Protein Binding; Time Factors | 1986 |
High-performance liquid chromatographic determination of carbamazepine and carbamazepine 10,11-epoxide in plasma and saliva following solid-phase sample extraction.
Topics: Carbamazepine; Child; Chromatography, High Pressure Liquid; Drug Stability; Humans; Indicators and Reagents; Saliva | 1986 |
Total and free serum concentrations of carbamazepine and carbamazepine-10,11-epoxide in children with epilepsy.
Topics: Adolescent; Carbamazepine; Child; Epilepsy; Female; Humans; Male | 1986 |
Carbamazepine-viloxazine interaction in patients with epilepsy.
Topics: Adult; Carbamazepine; Depressive Disorder; Drug Interactions; Drug Therapy, Combination; Epilepsy; Female; Humans; Male; Middle Aged; Morpholines; Viloxazine | 1986 |
A study on carbamazepine levels, including estimation of 10-11 epoxy-carbamazepine and levels in free plasma and saliva.
Topics: Adolescent; Carbamazepine; Child; Child, Preschool; Humans; Kinetics; Protein Binding; Saliva | 1986 |
Determination of total and free plasma carbamazepine concentrations by enzyme multiplied immunoassay: interference with the 10,11-epoxide metabolite.
Topics: Carbamazepine; Chromatography, High Pressure Liquid; Humans; Immunoenzyme Techniques; Methods | 1985 |
Inhibition of epoxidation of carbamazepine by valproic acid in the isolated perfused rat liver.
Topics: Animals; Carbamazepine; Chromatography, High Pressure Liquid; In Vitro Techniques; Injections, Intraperitoneal; Liver; Male; Metabolic Clearance Rate; Rats; Rats, Inbred Strains; Valproic Acid | 1985 |
The effect of storage conditions on the stability of carbamazepine and carbamazepine-10,11-epoxide in plasma.
Topics: Carbamazepine; Chromatography, High Pressure Liquid; Drug Stability; Humans; Specimen Handling; Temperature; Time Factors | 1986 |
Carbamazepine and carbamazepine-10,11-epoxide serum concentrations in epileptic children.
Topics: Adolescent; Age Factors; Carbamazepine; Child; Child, Preschool; Drug Therapy, Combination; Epilepsy; Ethosuximide; Female; Humans; Infant; Kinetics; Male; Phenobarbital; Phenytoin; Primidone; Sex Factors | 1985 |
Simultaneous plasma carbamazepine and carbamazepine-epoxide concentrations in pharmacokinetic and bioavailability studies.
Topics: Adult; Biological Availability; Carbamazepine; Chromatography, High Pressure Liquid; Female; Humans; Kinetics; Male; Models, Biological; Saliva | 1985 |
Death due to carbamazepine self-poisoning: remedies reviewed.
Topics: Adult; Carbamazepine; Hemodynamics; Humans; Male; Pneumonia, Aspiration; Suicide; Time Factors | 1985 |
Carbamazepine protein binding and disposition in pregnancy.
Topics: Adult; Blood Proteins; Carbamazepine; Female; Humans; Maternal-Fetal Exchange; Metabolic Clearance Rate; Pregnancy; Protein Binding | 1985 |
Carbamazepine and carbamazepine-epoxide serum protein binding in newborn infants.
Topics: Blood Proteins; Carbamazepine; Fetal Blood; Humans; Infant, Newborn; Protein Binding | 1985 |
Lateral gaze nystagmus in carbamazepine-treated epileptic patients: correlation with total and free plasma concentrations of parent drug and its 10,11-epoxide metabolite.
Topics: Adult; Carbamazepine; Epilepsy; Female; Humans; Male; Nystagmus, Pathologic; Phenobarbital | 1985 |
Simultaneous determination of carbamazepine and its epoxide metabolite in plasma and urine by high-performance liquid chromatography.
Topics: Bipolar Disorder; Carbamazepine; Chromatography, High Pressure Liquid; Drug Stability; Humans; Spectrophotometry, Ultraviolet | 1985 |
Alpha 1-acid glycoprotein concentration and serum protein binding of carbamazepine and carbamazepine-10,11 epoxide in children with epilepsy.
Topics: Carbamazepine; Child; Child, Preschool; Epilepsy; Female; Humans; Infant; Male; Orosomucoid; Protein Binding | 1985 |
Possible hazard of valpromide-carbamazepine combination therapy in epilepsy.
Topics: Anticonvulsants; Carbamazepine; Drug Synergism; Drug Therapy, Combination; Epilepsy; Humans; Valproic Acid | 1984 |
Carbamazepine levels in breast milk.
Topics: Adult; Carbamazepine; Epilepsy; Female; Humans; Immunoenzyme Techniques; Milk, Human; Spectrophotometry, Ultraviolet | 1984 |
Filtration for free drug level monitoring: carbamazepine and valproic acid.
Topics: Blood Proteins; Carbamazepine; Chromatography, Gas; Dialysis; Filtration; Humans; Protein Binding; Valproic Acid | 1984 |
Carbamazepine/valproic acid interaction in man and rhesus monkey.
Topics: Adolescent; Adult; Animals; Carbamazepine; Child; Dose-Response Relationship, Drug; Drug Interactions; Epilepsy; Female; Humans; Macaca mulatta; Male; Middle Aged; Valproic Acid | 1984 |
Altered ratio of carbamazepine-10,11-epoxide/carbamazepine in plasma of children: evidence of anticonvulsant drug interaction.
Topics: Anticonvulsants; Carbamazepine; Child; Chromatography, Gas; Chromatography, High Pressure Liquid; Drug Interactions; Drug Therapy, Combination; Epilepsy; Humans; Valproic Acid | 1984 |
Correlation between plasma carbamazepine-10,11-epoxide concentration and drug side-effects in children with epilepsy.
Topics: Adolescent; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Drug Therapy, Combination; Epilepsy; Humans; Valproic Acid | 1984 |
Development of a standardized analysis strategy for basic drugs, using ion-pair extraction and high-performance liquid chromatography. VI. Drug level determination in saliva.
Topics: Aminopyrine; Carbamazepine; Chromatography, High Pressure Liquid; Humans; Saliva | 1984 |
Determinants of carbamazepine and carbamazepine 10,11-epoxide binding to serum protein, albumin and alpha 1-acid glycoprotein.
Topics: Blood Proteins; Carbamazepine; Humans; In Vitro Techniques; Orosomucoid; Protein Binding; Serum Albumin | 1984 |
Individual and combined antiepileptic and neurotoxic activity of carbamazepine and carbamazepine-10,11-epoxide in mice.
Topics: Animals; Brain; Carbamazepine; Drug Synergism; Female; Mice; Mice, Inbred ICR; Nervous System; Proadifen; Seizures | 1984 |
Carbamazepine-10,11-diol steady-state serum levels and renal excretion during carbamazepine therapy in adults and children.
Topics: Adult; Biotransformation; Carbamazepine; Child; Epilepsy; Female; Humans; Kinetics; Male | 1984 |
A rapid, reversed phase liquid chromatographic technique for the simultaneous determination of carbamazepine and its 10,11-epoxide.
Topics: Carbamazepine; Chromatography, High Pressure Liquid; Female; Humans; Male; Nitrazepam; Saliva | 1984 |
Liquid chromatographic microassay for carbamazepine and its 10,11-epoxide in plasma.
Topics: Carbamazepine; Chromatography, High Pressure Liquid; Humans | 1984 |
Charcoal hemoperfusion in the treatment of two cases of acute carbamazepine poisoning.
Topics: Adult; Carbamazepine; Charcoal; Erythrocytes; Female; Hemoperfusion; Humans; Male; Middle Aged | 1984 |
Carbamazepine 10,11-epoxide in children.
Topics: Adolescent; Carbamazepine; Child; Child, Preschool; Drug Administration Schedule; Humans; Infant; Kinetics; Saliva | 1984 |
Effects of carbamazepine and its epoxide metabolite on amygdala-kindled seizures in rats.
Topics: Amygdala; Animals; Carbamazepine; Kindling, Neurologic; Male; Rats; Rats, Inbred Strains; Seizures | 1984 |
Free and total plasma concentrations of carbamazepine and carbamazepine-10,11-epoxide in epileptic patients: diurnal fluctuations and relationship with side effects.
Topics: Adult; Aged; Carbamazepine; Child; Circadian Rhythm; Epilepsy; Female; Humans; Male; Middle Aged | 1984 |
Fluctuations in salivary carbamazepine and carbamazepine-10,11-epoxide concentrations during the day in epileptic children.
Topics: Adolescent; Carbamazepine; Child; Circadian Rhythm; Epilepsy; Female; Humans; Male; Saliva | 1983 |
Pharmacokinetic aspects of carbamazepine and its two major metabolites in plasma during overdosage.
Topics: Biotransformation; Carbamazepine; Humans; Intestinal Absorption; Kinetics | 1983 |
Carbamazepine and its major metabolites in plasma: a summary of eight years of therapeutic drug monitoring.
Topics: Black People; Carbamazepine; Epilepsy; Humans; White People | 1983 |
Lack of interaction between cimetidine and carbamazepine.
Topics: Adult; Aged; Carbamazepine; Cimetidine; Drug Interactions; Female; Humans; Male; Middle Aged | 1983 |
Carbamazepine 10, 11 epoxide concentrations in epileptics on carbamazepine alone and in combination with other anticonvulsants.
Topics: Anticonvulsants; Carbamazepine; Drug Interactions; Drug Therapy, Combination; Epilepsy; Humans | 1983 |
Carbamazepine and carbamazepine-10,11- epoxide during pregnancy and postnatal period in epileptic mother and their nursed infants: pharmacokinetics and clinical effects.
Topics: Abnormalities, Drug-Induced; Carbamazepine; Chromatography, High Pressure Liquid; Epilepsy; Female; Half-Life; Humans; Infant, Newborn; Maternal-Fetal Exchange; Milk, Human; Pregnancy; Pregnancy Complications; Prospective Studies | 1983 |
Protein binding of carbamazepine and its epoxide in maternal and fetal plasma at delivery: comparison to other anticonvulsants.
Topics: Adult; Anticonvulsants; Carbamazepine; Chromatography, High Pressure Liquid; Epilepsy; Fatty Acids, Nonesterified; Female; Fetal Blood; Humans; Labor, Obstetric; Male; Pregnancy; Protein Binding; Serum Albumin; Triglycerides | 1984 |
Potent therapeutic effect of carbamazepine-10,11-epoxide in trigeminal neuralgia.
Topics: Aged; Carbamazepine; Female; Humans; Male; Middle Aged; Trigeminal Neuralgia | 1984 |
Routine monitoring of carbamazepine and carbamazepine-10,11-epoxide in plasma by high-performance liquid chromatography using 10-methoxycarbamazepine as internal standard.
Topics: Carbamazepine; Chromatography, Gas; Chromatography, High Pressure Liquid; Humans; Immunoenzyme Techniques; Reference Standards | 1982 |
Carbamazepine and its -10,11-epoxide metabolite in plasma and CSF. Relationship to antidepressant response.
Topics: Adult; Aged; Bipolar Disorder; Carbamazepine; Depressive Disorder; Female; Humans; Male; Middle Aged; Psychotic Disorders | 1983 |
Single-dose kinetics and metabolism of carbamazepine-10,11-epoxide.
Topics: Absorption; Adult; Carbamazepine; Female; Gastric Juice; Humans; Kinetics; Male; Middle Aged; Structure-Activity Relationship | 1983 |
Simultaneous high performance liquid-chromatographic determination of carbamazepine, carbamazepine-10,11-epoxide, ethosuximide, phenobarbital, phenytoin, primidone and phenylethylmalonamide in plasma.
Topics: Anticonvulsants; Carbamazepine; Chromatography, High Pressure Liquid; Ethosuximide; Humans; Phenobarbital; Phenylethylmalonamide; Phenytoin; Primidone | 1983 |
Quantitative simultaneous determination of eight common antiepileptic drugs and metabolites by liquid chromatography.
Topics: Anticonvulsants; Carbamazepine; Chromatography, Liquid; Ethosuximide; Humans; Phenobarbital; Phenylethylmalonamide; Phenytoin; Primidone; Succinimides | 1981 |
Influence of carbamazepine 10,11-oxide on drug metabolizing enzymes.
Topics: 7-Alkoxycoumarin O-Dealkylase; Animals; Carbamazepine; Cytochrome P-450 Enzyme System; Enzyme Induction; Epoxide Hydrolases; Glutathione Transferase; Kinetics; Liver; Male; Oxygenases; Rats | 1980 |
Carbamazepine determination in saliva of children: enzyme immunoassay (EMIT) versus high pressure liquid chromatography.
Topics: Carbamazepine; Child; Child, Preschool; Chromatography, High Pressure Liquid; Epilepsy; Humans; Immunoenzyme Techniques; Saliva | 1982 |
Simultaneous liquid-chromatographic determination of carbamazepine and its epoxide metabolite in plasma.
Topics: Carbamazepine; Child; Chromatography, High Pressure Liquid; Epilepsy; Evaluation Studies as Topic; Humans | 1982 |
Induction effect of phenobarbital on carbamazepine-10,11-epoxide kinetics in the rhesus monkey.
Topics: Animals; Biotransformation; Carbamazepine; Kinetics; Macaca mulatta; Male; Phenobarbital | 1982 |
Rapid gas chromatography method for the determination of carbamazepine and unrearranged carbamazepine-10,11-epoxide in human plasma.
Topics: Carbamazepine; Chromatography, Gas; Humans; Mass Spectrometry | 1981 |
Induction effect of phenobarbital on the carbamazepine to carbamazepine-10, 11-epoxide pathway in rhesus monkeys.
Topics: Animals; Carbamazepine; Drug Interactions; Enzyme Induction; Glucaric Acid; Kinetics; Macaca mulatta; Models, Biological; Phenobarbital; Time Factors | 1981 |
Factors influencing simultaneous concentrations of carbamazepine and its epoxide in plasma.
Topics: Adolescent; Adult; Aging; Anticonvulsants; Biotransformation; Carbamazepine; Drug Interactions; Female; Humans; Male; Sex Factors | 1981 |
Salivary concentrations and plasma protein binding of carbamazepine and carbamazepine 10,11-epoxide in epileptic patients.
Topics: Blood Proteins; Carbamazepine; Epilepsy; Female; Humans; Male; Protein Binding; Saliva | 1981 |
The formation of carbamazepine epoxide by rat liver microsomes: an investigation of the biphasic kinetic profile.
Topics: Aging; Animals; Carbamazepine; Kinetics; Male; Methylcholanthrene; Microsomes, Liver; Phenobarbital; Phenytoin; Rats; Rats, Inbred Strains | 1981 |
Influence of disulfiram on the serum concentration of carbamazepine in patients with epilepsy.
Topics: Adult; Carbamazepine; Disulfiram; Drug Interactions; Epilepsy; Female; Humans; Male; Middle Aged | 1981 |
Simultaneous liquid chromatographic analysis for carbamazepine and carbamazepine 10,11-epoxide in plasma and saliva by use of double internal standardization.
Topics: Carbamazepine; Chromatography, High Pressure Liquid; Epilepsy; Humans; Saliva | 1980 |
A quantitative method for the simultaneous determination of carbamazepine, mephenytoin, phenylethylmalonamide, phenobarbital, phenytoin and primidone in serum by thin-layer chromatography. Additional comments to the analysis of carbazepine-10,11-epoxide.
Topics: Anticonvulsants; Carbamazepine; Chromatography, Thin Layer; Humans; Phenylethylmalonamide; Primidone | 1980 |
Interactions of phenobarbital and phenytoin with carbamazepine and its metabolites' concentrations, concentration ratios, and level/dose ratios in epileptic children.
Topics: Biotransformation; Carbamazepine; Child; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; Drug Interactions; Drug Therapy, Combination; Enzyme Induction; Epilepsy; Female; Humans; Male; Oxidoreductases; Phenobarbital; Phenytoin | 1995 |
Single dose pharmacokinetics of carbamazepine-10,11-epoxide in patients on lamotrigine monotherapy.
Topics: Adult; Anticonvulsants; Carbamazepine; Drug Interactions; Epilepsy, Complex Partial; Female; Humans; Lamotrigine; Male; Middle Aged; Triazines | 1994 |
Efficacy of carbamazepine with respect to distribution of carbamazepine and its metabolite 10,11-epoxide in cerebral tumours and paratumorous cortex.
Topics: Adolescent; Adult; Aged; Biopsy; Brain Neoplasms; Carbamazepine; Cerebral Cortex; Child; Epilepsy; Female; Humans; Male; Middle Aged | 1994 |
In vivo binding characteristics of carbamazepine and carbamazepine 10, 11-epoxide to serum proteins in monotherapy adult patients.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Carbamazepine; Epilepsy; Female; Humans; Male; Middle Aged; Orosomucoid; Serum Albumin | 1994 |
Early stage autoinduction of carbamazepine metabolism in humans.
Topics: Acridines; Adult; Carbamazepine; Confidence Intervals; Humans; Male; Oxidation-Reduction | 1994 |
Six mutagenicity assays in exposure biomonitoring of patients receiving carbamazepine for epilepsy or trigeminal neuralgia.
Topics: Adolescent; Adult; Aged; Biotransformation; Carbamazepine; Case-Control Studies; Cell Division; Child; Chromosome Aberrations; Epilepsy; Female; Humans; Male; Micronucleus Tests; Middle Aged; Mitotic Index; Mutagenicity Tests; Salmonella typhimurium; Sister Chromatid Exchange; Statistics, Nonparametric; Trigeminal Neuralgia | 1995 |
Human liver carbamazepine metabolism. Role of CYP3A4 and CYP2C8 in 10,11-epoxide formation.
Topics: Adolescent; Adult; Biotransformation; Carbamazepine; Cells, Cultured; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; DNA, Complementary; Humans; Kinetics; Male; Microsomes, Liver; Middle Aged; Mixed Function Oxygenases; Transfection; Troleandomycin | 1994 |
The influence of polytherapy on the relationships between serum carbamazepine and its metabolites in epileptic children.
Topics: Aging; Anticonvulsants; Body Weight; Carbamazepine; Child; Chromatography, High Pressure Liquid; Drug Interactions; Drug Therapy, Combination; Epilepsy; Female; Humans; Male; Spectrophotometry, Ultraviolet; Valproic Acid | 1994 |
Measurement of carbamazepine and carbamazepine epoxide in the human brain using in vivo microdialysis.
Topics: Brain Chemistry; Carbamazepine; Extracellular Space; Humans; Microdialysis | 1994 |
Concentrations of carbamazepine and carbamazepine-10, 11-epoxide in serum, brain tumors and paratumorous cortex: a prospective study of 37 neurosurgically treated epileptic patients.
Topics: Adolescent; Adult; Aged; Biological Availability; Biopsy; Brain Neoplasms; Carbamazepine; Cerebral Cortex; Child; Dose-Response Relationship, Drug; Epilepsy; Female; Glioma; Humans; Male; Middle Aged | 1994 |
Validation of the analysis of carbamazepine and its 10,11-epoxide metabolite by high-performance liquid chromatography from plasma: comparison with gas chromatography and the enzyme-multiplied immunoassay technique.
Topics: Carbamazepine; Chromatography, Gas; Chromatography, High Pressure Liquid; Enzyme Multiplied Immunoassay Technique; Humans | 1993 |
Measurement of lamotrigine under conditions measuring phenobarbitone, phenytoin, and carbamazepine using reversed-phase high-performance liquid chromatography at dual wavelengths.
Topics: Anticonvulsants; Carbamazepine; Chromatography, High Pressure Liquid; Humans; Indicators and Reagents; Lamotrigine; Phenobarbital; Phenytoin; Spectrophotometry, Ultraviolet; Triazines | 1994 |
Seizure exacerbation and status epilepticus related to carbamazepine-10,11-epoxide.
Topics: Adult; Age of Onset; Carbamazepine; Female; Humans; Male; Middle Aged; Phenytoin; Seizures; Status Epilepticus | 1994 |
The use of antiepileptic drug levels in children: a survey of Canadian pediatric neurologists.
Topics: Adolescent; Anticonvulsants; Attitude of Health Personnel; Carbamazepine; Child; Epilepsy; Ethosuximide; Female; Humans; Male; Phenobarbital; Valproic Acid | 1993 |
In vivo and in vitro correlation of microsomal epoxide hydrolase inhibition by progabide.
Topics: Adult; Anticonvulsants; Carbamazepine; Drug Interactions; Epoxide Hydrolases; gamma-Aminobutyric Acid; Humans; In Vitro Techniques; Least-Squares Analysis; Male; Microsomes, Liver; Reference Values | 1993 |
In vivo determinations of carbamazepine and carbamazepine-10, 11-epoxide binding parameters to serum proteins in monotherapy patients.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Blood Proteins; Carbamazepine; Child; Child, Preschool; Female; Humans; Male; Middle Aged; Protein Binding | 1993 |
Saccharomyces cerevisiae: an alternative source for human microsomal liver enzymes and its use in drug interaction studies.
Topics: Anticonvulsants; Benzoflavones; Carbamazepine; Cloning, Molecular; Cytochrome P-450 CYP1A2; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; DNA, Complementary; Drug Interactions; Epoxide Hydrolases; Humans; Ketoconazole; Microsomes, Liver; Oxidoreductases, N-Demethylating; Saccharomyces cerevisiae; Valproic Acid | 1993 |
Determination of total and free carbamazepine and the principal metabolites in serum by high-performance liquid chromatography with photodiode-array detection.
Topics: Carbamazepine; Child; Chromatography, High Pressure Liquid; Epilepsy; Humans; Spectrophotometry, Ultraviolet; Ultrafiltration | 1993 |
Evaluation of the effect of fluoxetine on the formation of carbamazepine epoxide.
Topics: Animals; Carbamazepine; Drug Evaluation, Preclinical; Drug Interactions; Fluoxetine; Humans; In Vitro Techniques; Liver; Male; Microsomes, Liver; Perfusion; Rats; Rats, Sprague-Dawley | 1993 |
Carbamazepine and carbamazepine-10, 11-epoxide concentrations in rat brain and blood evaluated by in vivo microdialysis.
Topics: Animals; Brain; Carbamazepine; Corpus Striatum; Male; Microdialysis; Rats; Rats, Wistar | 1993 |
In vitro and in vivo microdialysis calibration for the measurement of carbamazepine and its metabolites in rat brain tissue using the internal reference technique.
Topics: Animals; Brain; Calibration; Carbamazepine; In Vitro Techniques; Male; Microdialysis; Rats; Rats, Wistar; Reference Standards | 1993 |
Carbamazepine and its metabolites in neuralgias: concentration-effect relations.
Topics: Adult; Aged; Aged, 80 and over; Carbamazepine; Chromatography, High Pressure Liquid; Enzyme Multiplied Immunoassay Technique; Female; Humans; Male; Middle Aged; Neuralgia; Regression Analysis | 1993 |
Transient steady-state analysis: application in the determination of the relative formation and elimination clearances of two major carbamazepine metabolites in humans.
Topics: Adult; Carbamazepine; Chromatography, High Pressure Liquid; Half-Life; Humans; Male; Models, Biological | 1993 |
Genetic differences in the time course for the development and persistence of the anticonvulsant effects of carbamazepine against cocaine seizures.
Topics: Animals; Anticonvulsants; Brain; Carbamazepine; Cocaine; Diet; Male; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Inbred Strains; Seizures; Species Specificity; Time Factors | 1993 |
The 10,11-epoxide-10,11-diol pathway of carbamazepine in early pregnancy in maternal serum, urine, and amniotic fluid: effect of dose, comedication, and relation to outcome of pregnancy.
Topics: Abnormalities, Drug-Induced; Amniotic Fluid; Carbamazepine; Cohort Studies; Dose-Response Relationship, Drug; Drug Interactions; Epilepsy; Female; Humans; Pregnancy; Pregnancy Complications; Pregnancy Outcome; Prenatal Exposure Delayed Effects; Prospective Studies; Tissue Distribution | 1993 |
Measurement of in vivo microsomal epoxide hydrolase activity in white subjects.
Topics: Adolescent; Adult; Carbamazepine; Epoxide Hydrolases; Female; Humans; Male; Metabolic Clearance Rate; Microsomes; Normal Distribution; Reference Values; White People | 1993 |
A simple collection method for saliva in children: potential for home monitoring of carbamazepine therapy.
Topics: Adolescent; Carbamazepine; Child; Child, Preschool; Chromatography, High Pressure Liquid; Drug Monitoring; Humans; Saliva; Self Care; Specimen Handling; Surveys and Questionnaires | 1993 |
In vivo binding characteristics of carbamazepine and carbamazepine-10,11-epoxide to serum proteins in paediatric patients with epilepsy.
Topics: Adolescent; Age Factors; Blood Proteins; Carbamazepine; Child; Child, Preschool; Epilepsy; Female; Humans; Male; Protein Binding | 1993 |
Postmortem concentrations of phenobarbital, carbamazepine, and its metabolite carbamazepine-10,11-epoxide in different regions of the brain and in the serum: analysis of autoptic specimens from 51 epileptic patients.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Autopsy; Brain Chemistry; Carbamazepine; Child; Child, Preschool; Epilepsy; Female; Humans; Infant; Male; Middle Aged; Phenobarbital; Tissue Distribution | 1993 |
Comparison of equations for predicting bound serum concentrations of carbamazepine and carbamazepine-10, 11-epoxide after polytherapy in patients with epilepsy.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anticonvulsants; Blood Proteins; Carbamazepine; Child; Child, Preschool; Epilepsy; Female; Humans; Infant; Male; Middle Aged; Protein Binding; Reproducibility of Results; Retrospective Studies | 1995 |
Evaluation of carbamazepine and carbamazepine-epoxide protein binding in patients undergoing epilepsy surgery.
Topics: Adult; Blood Proteins; Carbamazepine; Epilepsies, Partial; Epilepsy, Temporal Lobe; Female; Humans; Male; Orosomucoid; Postoperative Period; Protein Binding; Serum Albumin; Temporal Lobe | 1996 |
Carbamazepine-induced thrombocytopenia and carbamazepine-10,11-epoxide: a case report.
Topics: Adult; Anticonvulsants; Carbamazepine; Epilepsy; Female; Hemiplegia; Humans; Thrombocytopenia | 1995 |
Comparative effects of carbamazepine and carbamazepine-10,11-epoxide on hepatic cytochromes P450 in the rat.
Topics: Animals; Anticonvulsants; Aryl Hydrocarbon Hydroxylases; Carbamazepine; Cytochrome P-450 CYP2B1; Cytochrome P-450 CYP2E1; Cytochrome P-450 Enzyme System; Enzyme Induction; Female; Male; Microsomes, Liver; Phenobarbital; Rats; Steroid Hydroxylases | 1996 |
Interindividual and interspecies variation in hepatic microsomal epoxide hydrolase activity: studies with cis-stilbene oxide, carbamazepine 10, 11-epoxide and naphthalene.
Topics: Adult; Animals; Carbamazepine; Cricetinae; Cytochrome P-450 Enzyme System; Dogs; Epoxide Hydrolases; Exons; Female; Humans; Kinetics; Male; Mice; Microsomes, Liver; Middle Aged; Naphthalenes; Polymorphism, Genetic; Rabbits; Rats; Species Specificity; Stilbenes | 1996 |
Lack of influence of histopathological changes on carbamazepine and carbamazepine-10, 11-epoxide concentrations in the brain cortex of epileptic patients.
Topics: Adult; Aged; Aged, 80 and over; Anticonvulsants; Carbamazepine; Cerebral Cortex; Epilepsy; Female; Humans; Male; Middle Aged | 1996 |
High-speed liquid chromatographic method for the monitoring of carbamazepine and its active metabolite, carbamazepine-10,11-epoxide, in human plasma.
Topics: Anticonvulsants; Calibration; Carbamazepine; Chromatography, High Pressure Liquid; Circadian Rhythm; Humans; Reproducibility of Results; Spectrophotometry, Ultraviolet | 1996 |
In vitro embryotoxicity of carbamazepine and carbamazepine-10, 11-epoxide.
Topics: Animals; Carbamazepine; Mice; Rats; Teratogens | 1996 |
Teratogenicity of carbamazepine-10, 11-epoxide and oxcarbazepine in the SWV mouse.
Topics: Animals; Anticonvulsants; Carbamazepine; Female; Mice; Mice, Inbred Strains; Oxcarbazepine; Pregnancy; Teratogens | 1996 |
Pharmacokinetics of oxcarbazepine and carbamazepine in human placenta.
Topics: Anticonvulsants; Carbamazepine; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Epilepsy; Female; Fetal Blood; Humans; Mixed Function Oxygenases; Oxcarbazepine; Placenta; Pregnancy; Pregnancy Complications | 1997 |
Acute in vitro neuromuscular effects of carbamazepine and carbamazepine-10,11-epoxide.
Topics: Animals; Anticonvulsants; Carbamazepine; Dose-Response Relationship, Drug; In Vitro Techniques; Male; Neuromuscular Junction; Rats; Rats, Sprague-Dawley | 1997 |
High-performance liquid chromatographic determination of carbamazepine and metabolites in human hair.
Topics: Adult; Anticonvulsants; Carbamazepine; Chromatography, High Pressure Liquid; Hair; Humans; Reproducibility of Results; Sensitivity and Specificity; Spectrophotometry, Ultraviolet | 1997 |
Optimized high-performance liquid chromatographic method for determination of lamotrigine in serum with concomitant determination of phenytoin, carbamazepine, and carbamazepine epoxide.
Topics: Anticonvulsants; Carbamazepine; Chromatography, High Pressure Liquid; Humans; Lamotrigine; Phenytoin; Triazines | 1997 |
Effect of lamotrigine on carbamazepine epoxide/carbamazepine serum concentration ratios in adult patients with epilepsy.
Topics: Administration, Oral; Adult; Anticonvulsants; Carbamazepine; Epilepsy; Female; Humans; Lamotrigine; Male; Metabolic Clearance Rate; Triazines | 1997 |
No increase in carbamazepine-10,11-epoxide during addition of lamotrigine treatment in children.
Topics: Adolescent; Adult; Anticonvulsants; Carbamazepine; Child; Drug Interactions; Drug Monitoring; Epilepsy, Generalized; Humans; Lamotrigine; Triazines | 1997 |
Determination of lamotrigine, carbamazepine and carbamazepine epoxide in human serum by gas chromatography mass spectrometry.
Topics: Anticonvulsants; Carbamazepine; Chromatography, High Pressure Liquid; Drug Monitoring; Fluorescence Polarization Immunoassay; Gas Chromatography-Mass Spectrometry; Humans; Lamotrigine; Pressure; Reference Values; Reproducibility of Results; Temperature; Triazines | 1997 |
An active metabolite of carbamazepine, carbamazepine-10,11-epoxide, inhibits ion channel-mediated catecholamine secretion in cultured bovine adrenal medullary cells.
Topics: Adrenal Medulla; Animals; Anti-Anxiety Agents; Benzodiazepines; Calcium; Carbachol; Carbamazepine; Catecholamines; Cattle; Cells, Cultured; Cholinergic Agonists; Ion Channels; Sodium | 1998 |
Simultaneous determination of phenytoin, carbamazepine, and 10,11-carbamazepine epoxide in human plasma by high-performance liquid chromatography with ultraviolet detection.
Topics: Carbamazepine; Chromatography, High Pressure Liquid; Humans; Phenytoin; Sensitivity and Specificity; Spectrophotometry, Ultraviolet | 1998 |
Carbamazepine toxicity with lamotrigine: pharmacokinetic or pharmacodynamic interaction?
Topics: Anticonvulsants; Carbamazepine; Child; Diplopia; Dizziness; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Interactions; Drug Therapy, Combination; Epilepsy; Humans; Lamotrigine; Triazines | 1998 |
A partial area difference analysis for estimating elimination rate constants and distribution volumes of metabolites.
Topics: Adult; Anticonvulsants; Carbamazepine; Humans | 1998 |
The incorporation of lamotrigine into the routine automated sequential trace enrichment of dialysates assay of anticonvulsants.
Topics: Anticonvulsants; Carbamazepine; Chromatography, High Pressure Liquid; Humans; Lamotrigine; Phenobarbital; Phenytoin; Triazines | 1998 |
Carbamazepine-10,11-epoxide in therapeutic drug monitoring.
Topics: Adult; Anticonvulsants; Carbamazepine; Chromatography, High Pressure Liquid; Drug Interactions; Drug Monitoring; Female; Fluorescence Polarization Immunoassay; Humans; Lamotrigine; Phenytoin; Sodium Channels; Triazines; Valproic Acid | 1998 |
Comparison between premortem and postmortem serum concentrations of phenobarbital, phenytoin, carbamazepine and its 10,11-epoxide metabolite in institutionalized patients with epilepsy.
Topics: Adult; Aged; Aged, 80 and over; Anticonvulsants; Carbamazepine; Epilepsy; Female; Hospitalization; Humans; Male; Middle Aged; Phenobarbital; Phenytoin; Postmortem Changes; Time Factors | 1999 |
Effects of carbamazepine on hepatic glutathione level in rats and determination of carbamazepine and its epoxide metabolite in plasma by HPLC.
Topics: Animals; Anticonvulsants; Carbamazepine; Chromatography, High Pressure Liquid; Glutathione; Liver; Male; Rats; Rats, Wistar | 1998 |
Monitoring of carbamazepine and carbamazepine 10,11-epoxide in breast milk and plasma by high-performance liquid chromatography.
Topics: Adult; Anticonvulsants; Calibration; Carbamazepine; Chromatography, High Pressure Liquid; Female; Humans; Japan; Lactation; Milk, Human; Reproducibility of Results; Time Factors | 2000 |
Subcutaneous microdialysis in rats correlates with carbamazepine concentrations in plasma and brain.
Topics: Animals; Anticonvulsants; Area Under Curve; Brain; Carbamazepine; Female; Microdialysis; Osmolar Concentration; Rats; Rats, Sprague-Dawley; Skin | 2000 |
Lack of effect of St John's Wort on carbamazepine pharmacokinetics in healthy volunteers.
Topics: Adult; Anticonvulsants; Carbamazepine; Drug Interactions; Humans; Hypericum; Male; Plants, Medicinal | 2000 |
Characterization of cross reactivity by carbamazepine 10,11-epoxide with carbamazepine assays.
Topics: Anticonvulsants; Carbamazepine; Chemistry, Clinical; Drug Interactions; Humans | 2001 |
Determination of carbamazepine and carbamazepine-10,11-epoxide in human serum and plasma by micellar electrokinetic capillary chromatography in the absence of electroosmosis.
Topics: Carbamazepine; Chromatography; Electrophoresis, Capillary; Humans | 2001 |
Determination of carbamazepine and its metabolite carbamazepine-10,11-epoxide in serum with gas-chromatography mass spectrometry.
Topics: Adolescent; Adult; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Chromatography, High Pressure Liquid; Gas Chromatography-Mass Spectrometry; Humans; Infant; Middle Aged | 2001 |
Determination of carbamazepine and carbamazepine 10,11-epoxide in human plasma by tandem liquid chromatography-mass spectrometry with electrospray ionisation.
Topics: Calibration; Carbamazepine; Chromatography, Liquid; Humans; Reproducibility of Results; Sensitivity and Specificity; Spectrometry, Mass, Electrospray Ionization | 2002 |
Decreased bioavailability of carbamazepine suppository after its intrarectal and intracolostomal administration to rectal-resected or colostoma-constructed rabbits.
Topics: Administration, Oral; Administration, Rectal; Animals; Anticonvulsants; Biological Availability; Carbamazepine; Rabbits | 2002 |
Elevation of carbamazepine-10,11-epoxide by quetiapine.
Topics: Ataxia; Carbamazepine; Dibenzothiazepines; Drug Synergism; Female; Humans; Male; Middle Aged; Psychomotor Agitation; Quetiapine Fumarate | 2002 |
Carbamazepine poisoning: elimination kinetics and quantitative relationship with carbamazepine 10,11-epoxide.
Topics: Adult; Analgesics, Non-Narcotic; Biotransformation; Carbamazepine; Central Nervous System Depressants; Coma; Ethanol; Female; Humans; Male; Poisoning | 2002 |
Comment on antiepileptics and antipsychotics.
Topics: Animals; Anticonvulsants; Antipsychotic Agents; Carbamazepine; Female; Folic Acid; Hematinics; Humans; Mice; Neural Tube Defects; Pregnancy; Rats | 2002 |
Cross-reactivity assessment of carbamazepine-10,11-epoxide, oxcarbazepine, and 10-hydroxy-carbazepine in two automated carbamazepine immunoassays: PETINIA and EMIT 2000.
Topics: Adult; Carbamazepine; Chromatography, High Pressure Liquid; Cross Reactions; Enzyme Multiplied Immunoassay Technique; Female; Fluorescence Polarization Immunoassay; Humans; Immunoassay; Linear Models; Male; Middle Aged; Nephelometry and Turbidimetry; Oxcarbazepine | 2003 |
CYP3A4 and CYP3A7-mediated carbamazepine 10,11-epoxidation are activated by differential endogenous steroids.
Topics: Animals; Anticonvulsants; Aryl Hydrocarbon Hydroxylases; Arylsulfatases; Benzoflavones; Carbamazepine; Cells, Cultured; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Dose-Response Relationship, Drug; Humans; In Vitro Techniques; Insecta; Kinetics; Steroid Hydroxylases; Steroids; Steryl-Sulfatase; Substrate Specificity | 2003 |
Patch testing with carbamazepine and its main metabolite carbamazepine epoxide in cutaneous adverse drug reactions to carbamazepine.
Topics: Adolescent; Adult; Aged; Allergens; Anticonvulsants; Carbamazepine; Case-Control Studies; Drug Eruptions; Female; Humans; Male; Middle Aged; Patch Tests | 2003 |
How suitable are currently used carbamazepine immunoassays for quantifying carbamazepine-10,11-epoxide in serum samples?
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Carbamazepine; Child; Child, Preschool; Female; Humans; Immunoassay; Male; Middle Aged | 2003 |
Inhibitory effect of stiripentol on carbamazepine and saquinavir metabolism in human.
Topics: Adolescent; Anticonvulsants; Carbamazepine; Child; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Dioxolanes; Drug Interactions; HIV Protease Inhibitors; Humans; In Vitro Techniques; Microsomes, Liver; Saquinavir; Time Factors | 2003 |
Direct interaction between substrates and endogenous steroids in the active site may change the activity of cytochrome P450 3A4.
Topics: Adult; Aldosterone; Androstenedione; Binding Sites; Carbamazepine; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Enzyme Stability; Estradiol; Humans; Hydroxylation; Kinetics; Mutation; Nevirapine; Serine; Substrate Specificity | 2003 |
Interference of carbamazepine and carbamazepine 10,11-epoxide in the fluorescence polarization immunoassay for tricyclic antidepressants: estimation of the true tricyclic antidepressant concentration in the presence of carbamazepine using a mathematical m
Topics: Antidepressive Agents, Tricyclic; Carbamazepine; Fluorescence Polarization Immunoassay; Humans; Models, Theoretical; Sensitivity and Specificity | 2004 |
Population pharmacokinetic modeling of steady state clearance of carbamazepine and its epoxide metabolite from sparse routine clinical data.
Topics: Administration, Oral; Adolescent; Adult; Anticonvulsants; Asian People; Body Weight; Carbamazepine; Chromatography, High Pressure Liquid; Drug Administration Schedule; Drug Therapy, Combination; Female; Humans; Male; Metabolic Clearance Rate; Methods; Models, Biological; Pharmacokinetics; Phenobarbital; Phenytoin; Regression Analysis; Valproic Acid | 2004 |
Analytic performance evaluation of a new turbidimetric immunoassay for carbamazepine on the ADVIA 1650 analyzer: effect of carbamazepine 10,11-epoxide.
Topics: Carbamazepine; Chemistry, Pharmaceutical; Fluorescence Polarization Immunoassay; Humans; Immunoassay; Luminescent Measurements; Nephelometry and Turbidimetry; Sensitivity and Specificity | 2005 |
Carbamazepine is an inhibitor of histone deacetylases.
Topics: Acetylation; Anticonvulsants; Carbamazepine; Cell Line, Tumor; Dose-Response Relationship, Drug; Enzyme Inhibitors; Hepatocytes; Histone Deacetylase Inhibitors; Histone Deacetylases; Histones; Humans; Valproic Acid | 2005 |
Human in vitro glutathionyl and protein adducts of carbamazepine-10,11-epoxide, a stable and pharmacologically active metabolite of carbamazepine.
Topics: Carbamazepine; Glutathione; Humans; Microsomes, Liver; Protein Binding | 2005 |
Simultaneous determination of zonisamide, carbamazepine and carbamazepine-10,11-epoxide in infant serum by high-performance liquid chromatography.
Topics: Anticonvulsants; Carbamazepine; Chromatography, High Pressure Liquid; Epilepsy; Humans; Infant; Isoxazoles; Zonisamide | 2006 |
A PLS-based extractive spectrophotometric method for simultaneous determination of carbamazepine and carbamazepine-10,11-epoxide in plasma and comparison with HPLC.
Topics: Adult; Calibration; Carbamazepine; Chromatography, High Pressure Liquid; Humans; Least-Squares Analysis; Middle Aged; Spectrophotometry, Ultraviolet | 2007 |
Quantification of carbamazepine, carbamazepine-10,11-epoxide, phenytoin and phenobarbital in plasma samples by stir bar-sorptive extraction and liquid chromatography.
Topics: Carbamazepine; Chromatography, High Pressure Liquid; Drug Monitoring; Humans; Phenobarbital; Phenytoin; Sensitivity and Specificity | 2008 |
Chemometric resolution of fully overlapped CE peaks: quantitation of carbamazepine in human serum in the presence of several interferences.
Topics: Algorithms; Analysis of Variance; Anticonvulsants; Carbamazepine; Electrophoresis, Capillary; Humans; Least-Squares Analysis; Linear Models; Multivariate Analysis; Pharmaceutical Preparations; Reproducibility of Results; Sensitivity and Specificity; Software | 2008 |
Instrumental planar chromatographic method for determination of carbamazepine in human serum.
Topics: Calibration; Carbamazepine; Chromatography, Thin Layer; Densitometry; Humans; Reproducibility of Results; Silica Gel; Silicon Dioxide; Solvents; Spectrometry, Fluorescence | 2009 |
Effect of berberine on the pharmacokinetics of substrates of CYP3A and P-gp.
Topics: Animals; Area Under Curve; ATP Binding Cassette Transporter, Subfamily B, Member 1; Berberine; Biological Availability; Carbamazepine; Cyclosporine; Cytochrome P-450 CYP3A; Digoxin; Drug Interactions; Male; Rats; Rats, Wistar | 2009 |
Estimation of carbamazepine and carbamazepine-10,11-epoxide concentrations in plasma using mathematical equations generated with two carbamazepine immunoassays.
Topics: Carbamazepine; Chromatography, High Pressure Liquid; Computational Biology; Cross Reactions; Enzyme Multiplied Immunoassay Technique; Fluorescence Polarization Immunoassay; Humans; Immunoassay; Nephelometry and Turbidimetry; Reproducibility of Results; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry | 2010 |
Development and validation of an HPLC-UV method for the simultaneous quantification of carbamazepine, oxcarbazepine, eslicarbazepine acetate and their main metabolites in human plasma.
Topics: Carbamazepine; Chromatography, High Pressure Liquid; Dibenzazepines; Humans; Molecular Structure; Oxcarbazepine; Sensitivity and Specificity; Spectrophotometry, Ultraviolet; Stereoisomerism | 2010 |
Analytical performance evaluation of ADVIA Chemistry Carbamazepine_2 assay: minimal cross-reactivity with carbamazepine 10, 11-epoxide and none with hydroxyzine or cetirizine.
Topics: Anticonvulsants; Blood Chemical Analysis; Carbamazepine; Cetirizine; Drug Monitoring; Humans; Hydroxyzine; Immunoassay; Linear Models; Reproducibility of Results; Sensitivity and Specificity | 2010 |
In vivo solid-phase microextraction for single rodent pharmacokinetics studies of carbamazepine and carbamazepine-10,11-epoxide in mice.
Topics: Animals; Blood Specimen Collection; Carbamazepine; Chromatography, Liquid; Equipment Design; Linear Models; Male; Mice; Reproducibility of Results; Solid Phase Microextraction; Tandem Mass Spectrometry | 2011 |
Occurrence and removal of pharmaceuticals and hormones through drinking water treatment.
Topics: Atenolol; Carbamazepine; Hormones; Hydrochlorothiazide; Ozone; Pharmaceutical Preparations; Phenytoin; Sotalol; Water Pollutants, Chemical; Water Purification; Water Supply | 2011 |
Discordant carbamazepine values between two immunoassays: carbamazepine values determined by ADVIA Centaur correlate better with those determined by LC-MS/MS than PETINIA assay.
Topics: Carbamazepine; Chromatography, Liquid; Humans; Immunoassay; Mass Spectrometry; Reagent Kits, Diagnostic | 2011 |
Carbamazepine and the active epoxide metabolite are effectively cleared by hemodialysis followed by continuous venovenous hemodialysis in an acute overdose.
Topics: Adult; Analgesics, Non-Narcotic; Carbamazepine; Drug Overdose; Half-Life; Humans; Male; Renal Dialysis; Time Factors | 2011 |
Assessment of the health risks related to the presence of drug residues in water for human consumption: application to carbamazepine.
Topics: Animals; Anticonvulsants; Carbamazepine; Dogs; Environmental Monitoring; Humans; Mice; Rabbits; Rats; Rats, Sprague-Dawley; Risk Assessment; Water Pollutants, Chemical; Water Supply | 2012 |
CSF concentrations and serum protein binding of carbamazepine and carbamazepine-10,11-epoxide in epileptic patients.
Topics: Adolescent; Adult; Blood Proteins; Carbamazepine; Epilepsy; Humans; Male; Protein Binding; Young Adult | 1976 |
Carbamazepine, carbamazepine epoxide and dihydroxycarbamazepine sorption to soil and occurrence in a wastewater reuse site in Tunisia.
Topics: Adsorption; Carbamazepine; Soil; Tunisia; Waste Disposal, Fluid; Water Pollutants, Chemical | 2012 |
A new herb-drug interaction of Polygonum cuspidatum, a resveratrol-rich nutraceutical, with carbamazepine in rats.
Topics: Administration, Oral; Animals; Anticonvulsants; Area Under Curve; Brain; Carbamazepine; Chromatography, High Pressure Liquid; Cross-Over Studies; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Fallopia japonica; Herb-Drug Interactions; Kidney; Liver; Male; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Plant Extracts; Rats; Rats, Sprague-Dawley; Resveratrol; Stilbenes; Tissue Distribution | 2012 |
The effect of poor compliance on the pharmacokinetics of carbamazepine and its epoxide metabolite using Monte Carlo simulation.
Topics: Anticonvulsants; Asian People; Carbamazepine; China; Computer Simulation; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Interactions; Epilepsy; Humans; Medication Adherence; Monte Carlo Method; Time Factors | 2012 |
Evaluation of a novel mouse model of intracisternal strychnine-induced trigeminal allodynia.
Topics: Analgesics, Non-Narcotic; Animals; Carbamazepine; Cerebrospinal Fluid; Cisterna Magna; Disease Models, Animal; Female; Glycine; Glycine Agents; Injections; Injections, Subcutaneous; Mice; Morphine; Narcotics; Pain Measurement; Random Allocation; Single-Blind Method; Strychnine; Trigeminal Neuralgia | 2013 |
Effect of Sophora flavescens on the pharmacokinetics of carbamazepine in rats.
Topics: Animals; Area Under Curve; ATP-Binding Cassette Transporters; Carbamazepine; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP3A; Dose-Response Relationship, Drug; Drug Interactions; Male; Plant Extracts; Plant Roots; Rats, Sprague-Dawley; Sophora; Substrate Specificity; Time Factors; Tissue Distribution | 2014 |
Routine therapeutic monitoring of the active metabolite of carbamazepine: Is it really necessary?
Topics: Carbamazepine; Chromatography, High Pressure Liquid; Drug Monitoring; Drug Therapy, Combination; Humans; Immunoassay; Regression Analysis | 2015 |
In vivo exposure of marine mussels to carbamazepine and 10-hydroxy-10,11-dihydro-carbamazepine: Bioconcentration and metabolization.
Topics: Animals; Anticonvulsants; Carbamazepine; Environmental Monitoring; Mytilus; Water Pollutants, Chemical | 2015 |
Determination of the psychoactive drugs carbamazepine and diazepam in hospital effluent and identification of their metabolites.
Topics: Brazil; Carbamazepine; Chromatography, Liquid; Diazepam; Hospitals, University; Medical Waste; Psychotropic Drugs; Sewage; Spectrometry, Mass, Electrospray Ionization; Wastewater; Water Pollutants, Chemical | 2015 |
Phytoremediation of carbamazepine and its metabolite 10,11-epoxycarbamazepine by C3 and C4 plants.
Topics: Anticonvulsants; Biodegradation, Environmental; Carbamazepine; Chromatography, High Pressure Liquid; Czech Republic; Helianthus; Hydroponics; Plant Leaves; Soil Pollutants; Zea mays | 2015 |
A Case Report of a Carbamazepine Overdose With Focus on Pharmacokinetic Aspects.
Topics: Carbamazepine; Charcoal; Drug Monitoring; Drug Overdose; Humans; Male; Middle Aged | 2016 |
Prediction of drug-drug interactions with carbamazepine-10,11-epoxide using a new in vitro assay for epoxide hydrolase inhibition.
Topics: Biological Assay; Carbamazepine; Drug Interactions; Enzyme Inhibitors; Epoxide Hydrolases; Humans | 2016 |
Carbamazepine and carbamazepine-10,11-epoxide clearance measurements during continuous venovenous hemofiltration in a massive overdose.
Topics: Adult; Anticonvulsants; Carbamazepine; Chromatography, High Pressure Liquid; Drug Overdose; Female; Hemofiltration; Humans; Metabolic Clearance Rate; Renal Dialysis; Treatment Outcome | 2016 |
Concentrations of carbamazepine and carbamazepine-10,11-epoxide in maternal and umbilical cord blood at birth: Influence of co-administration of valproic acid or enzyme-inducing antiepileptic drugs.
Topics: Adolescent; Adult; Anticonvulsants; Blood Chemical Analysis; Carbamazepine; Dose-Response Relationship, Drug; Drug Interactions; Drug Therapy, Combination; Epilepsy; Female; Fetal Blood; Humans; Pregnancy; Pregnancy Complications; Retrospective Studies; Valproic Acid; Young Adult | 2016 |
Effect of Carbamazepine 10, 11-Epoxide on Serum Carbamazepine Measurement Using a New CMIA Assay: Comparison of Values Obtained by Using PETINIA, CEDIA and Liquid Chromatography Combined with Tandem Mass Spectrometry.
Topics: Carbamazepine; Chromatography, Liquid; Humans; Immunoassay; Luminescent Measurements; Regression Analysis; Tandem Mass Spectrometry | 2016 |
Development, validation and clinical application of an online-SPE-LC-HRMS/MS for simultaneous quantification of phenobarbital, phenytoin, carbamazepine, and its active metabolite carbamazepine 10,11-epoxide.
Topics: Adult; Anticonvulsants; Carbamazepine; Chromatography, High Pressure Liquid; Drug Monitoring; Epilepsy; Female; Humans; Male; Phenobarbital; Phenytoin; Reproducibility of Results; Solid Phase Extraction; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry | 2016 |
Transformation of atenolol, metoprolol, and carbamazepine in soils: The identification, quantification, and stability of the transformation products and further implications for the environment.
Topics: Atenolol; Carbamazepine; Groundwater; Humans; Metoprolol; Soil; Soil Pollutants | 2016 |
Serum protein binding of 25 antiepileptic drugs in a routine clinical setting: A comparison of free non-protein-bound concentrations.
Topics: Adult; Anticonvulsants; Benzodiazepines; Biological Availability; Blood-Brain Barrier; Carbamazepine; Epilepsy; Gas Chromatography-Mass Spectrometry; Humans; Protein Binding; Retrospective Studies | 2017 |
Determination of carbamazepine and 12 degradation products in various compartments of an outdoor aquatic mesocosm by reliable analytical methods based on liquid chromatography-tandem mass spectrometry.
Topics: Animals; Carbamazepine; Chromatography, Liquid; Tandem Mass Spectrometry; Water Pollutants, Chemical | 2017 |
Carbamazepine 10,11-epoxidation in human liver microsomes: influence of the
Topics: Adult; Aged; Anticonvulsants; Carbamazepine; Cytochrome P-450 CYP3A; Female; Genotype; Humans; Male; Microsomes, Liver; Middle Aged; Polymorphism, Genetic | 2017 |
Carbamazepine-Mediated Adverse Drug Reactions: CBZ-10,11-epoxide but Not Carbamazepine Induces the Alteration of Peptides Presented by HLA-B∗15:02.
Topics: Allergens; Anticonvulsants; Antigen Presentation; B-Lymphocytes; Binding Sites; Carbamazepine; Cell Line; Drug Hypersensitivity; Drug-Related Side Effects and Adverse Reactions; HLA-B15 Antigen; Humans; Immunomodulation; Mass Spectrometry; Peptide Fragments; Protein Binding | 2018 |
Is brivaracetam-induced elevation of carbamazepine-epoxide levels common and clinically relevant? - A case series.
Topics: Adult; Carbamazepine; Epilepsies, Partial; Female; Humans; Male; Middle Aged; Pyrrolidinones; Seizures | 2020 |
Development of a monoclonal antibody-based immunochromatographic assay for the detection of carbamazepine and carbamazepine-10, 11-epoxide.
Topics: Antibodies, Immobilized; Antibodies, Monoclonal; Carbamazepine; Chromatography, Liquid; Humans; Immunoassay; Limit of Detection; Linear Models | 2020 |
The effect of cannabidiol on the pharmacokinetics of carbamazepine in rats.
Topics: Animals; Anticonvulsants; Cannabidiol; Carbamazepine; Dose-Response Relationship, Drug; Drug Interactions; Male; Rats; Rats, Sprague-Dawley | 2020 |
Quantification of 10,11-dihydro-10-hydroxy carbamazepine and 10,11-epoxycarbamazepine as the main by-products in the electrochemical degradation of carbamazepine.
Topics: Anticonvulsants; Carbamazepine; Chromatography, High Pressure Liquid; Chromatography, Liquid; Wastewater | 2022 |