carbamazepine and ketoconazole

carbamazepine has been researched along with ketoconazole in 48 studies

Research

Studies (48)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	5 (10.42)	18.2507
2000's	12 (25.00)	29.6817
2010's	30 (62.50)	24.3611
2020's	1 (2.08)	2.80

Authors

Authors	Studies
Alvarez-Pedraglio, A; Colmenarejo, G; Lavandera, JL	1
Doman, TN; McGovern, SL; Seidler, J; Shoichet, BK	1
Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL	1
Bellows, DS; Clarke, ID; Diamandis, P; Dirks, PB; Graham, J; Jamieson, LG; Ling, EK; Sacher, AG; Tyers, M; Ward, RJ; Wildenhain, J	1
Artursson, P; Bergström, CA; Hoogstraate, J; Matsson, P; Norinder, U; Pedersen, JM	1
Ahlin, G; Artursson, P; Bergström, CA; Gustavsson, L; Karlsson, J; Larsson, R; Matsson, P; Norinder, U; Pedersen, JM	1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A	1
Choi, SS; Contrera, JF; Hastings, KL; Kruhlak, NL; Sancilio, LF; Weaver, JL; Willard, JM	1
García-Mera, X; González-Díaz, H; Prado-Prado, FJ	1
Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ	1
Glen, RC; Lowe, R; Mitchell, JB	1
Ekins, S; Williams, AJ; Xu, JJ	1
Sen, S; Sinha, N	1
Chen, M; Fang, H; Liu, Z; Shi, Q; Tong, W; Vijay, V	1
Barber, J; Dawson, S; Kenna, JG; Paul, N; Stahl, S	1
Artursson, P; Haglund, U; Karlgren, M; Kimoto, E; Lai, Y; Norinder, U; Vildhede, A; Wisniewski, JR	1
Ambroso, JL; Ayrton, AD; Baines, IA; Bloomer, JC; Chen, L; Clarke, SE; Ellens, HM; Harrell, AW; Lovatt, CA; Reese, MJ; Sakatis, MZ; Taylor, MA; Yang, EY	1
Cantin, LD; Chen, H; Kenna, JG; Noeske, T; Stahl, S; Walker, CL; Warner, DJ	1
Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ	1
Artursson, P; Mateus, A; Matsson, P	1
Bathurst, I; Burrows, JN; Charman, SA; Cross, RM; Flanigan, DL; Fronczek, FR; Guida, WC; Kyle, DE; LaCrue, AN; Maignan, JR; Manetsch, R; Monastyrskyi, A; Mutka, TS; Sáenz, FE; Shackleford, DM; White, KL; Wojtas, L	1
Filipek, B; Kamiński, K; Kieć-Kononowicz, K; Latacz, G; Obniska, J; Rapacz, A; Łuszczki, JJ	1
Andres-Mach, M; Kamiński, K; Kieć-Kononowicz, K; Latacz, G; Rapacz, A; Zagaja, M; Łuszczki, JJ	1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K	1
Denning, DW; Graybill, JR; Hanson, LH; Pappagianis, D; Rinaldi, MG; Sharkey, PK; Stevens, DA; Tucker, RM	1
Breckenridge, AM; Guenthner, TM; Kitteringham, NR; Park, BK; Pirmohamed, M	1
Eugster, HP; Sengstag, C	1
Arena, D; Fazio, A; Perucca, E; Pisani, F; Scordo, MG; Spina, E	1
Pagano, R	1
Auchère, D; Bonhomme-Faivre, L; Farinotti, R; Forestier, F; Orbach-Arbouys, S; Soursac, M	1
Grimm, SW; Reele, SB; Richtand, NM; Stams, KR; Winter, HR	1
de Kanter, R; Groothuis, G; Martignoni, M	1
Böttiger, Y	1
Arya, N; Beelen, A; Bowen, CJ; Herendeen, JM; Koch, KM; Smith, DA	1
Castberg, I; Davies, SJ; Lennard, MS; Lewis, G; Spigset, O; Taylor, S; Westin, AA	1
Chen, Y; Groothuis, GM; Hadi, M; Merema, MT; Starokozhko, V	1
Assaf, M; Hoffmann, M; Kasserra, C; Kumar, G; Li, Y; Liu, L; Palmisano, M; Wang, X	1
Boinpally, R; Gad, N; Gupta, S; Periclou, A	1
Ghosh, A; Ghosh, C; Grant, GA; Hossain, M; Janigro, D; Marchi, N; Perucca, E; Spriggs, A	1
Fukami, T; Iida, A; Nakajima, M; Sasaki, E; Tsuneyama, K; Yano, A; Yokoi, T	1
Boinpally, R; Chen, L; Gad, N; Ghahramani, P; Greenberg, WM; Periclou, A; Wangsa, J	1
Cai, JP; Chen, M; Chen, X; Gu, E; Hu, G; Wang, L; Wang, S; Zheng, X; Zhou, H	1
De Jong, J; de Zwart, L; Mannaert, E; Monshouwer, M; Snoeys, J; Sukbuntherng, J	1
Cleary, Y; Fowler, S; Greig, G; Guerini, E; Mallalieu, NL; Parrott, N; Qiu, N	1
Grewal, GK; Jajodia, A; Kanojia, N; Kukal, S; Kukreti, R; Misra, R; Muthusamy, K; Nagamani, S; Rawat, C; Singh, KD; Singhal, A	1
Fu, J; Lv, K; Sun, W; Wang, J; Yin, X; Zhang, J	1
Jones, LH; Nadanaciva, S; Rana, P; Will, Y	1
Brodsky, JL; Chiang, A; Chung, WJ; Denny, RA; Goeckeler-Fried, JL; Havasi, V; Hong, JS; Keeton, AB; Mazur, M; Piazza, GA; Plyler, ZE; Rasmussen, L; Rowe, SM; Sorscher, EJ; Weissman, AM; White, EL	1

Reviews

1 review(s) available for carbamazepine and ketoconazole

Article	Year
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans. Drug discovery today, 2016, Volume: 21, Issue:4 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk	2016

Trials

8 trial(s) available for carbamazepine and ketoconazole

Article	Year
Effects of cytochrome P450 3A modulators ketoconazole and carbamazepine on quetiapine pharmacokinetics. British journal of clinical pharmacology, 2006, Volume: 61, Issue:1 Topics: Administration, Oral; Adult; Antipsychotic Agents; Carbamazepine; Cross-Over Studies; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Dibenzothiazepines; Drug Interactions; Drug Therapy, Combination; Enzyme Induction; Enzyme Inhibitors; Female; Humans; Isoenzymes; Ketoconazole; Male; Mental Disorders; Microsomes, Liver; Middle Aged; Quetiapine Fumarate	2006
Use of omeprazole sulfone in a single plasma sample as a probe for CYP3A4. European journal of clinical pharmacology, 2006, Volume: 62, Issue:8 Topics: Adult; Aged; Aryl Hydrocarbon Hydroxylases; Carbamazepine; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Drug Interactions; Enzyme Activators; Enzyme Inhibitors; Female; Humans; Ketoconazole; Male; Middle Aged; Mixed Function Oxygenases; Omeprazole; Pharmacogenetics	2006
Effects of ketoconazole and carbamazepine on lapatinib pharmacokinetics in healthy subjects. British journal of clinical pharmacology, 2009, Volume: 67, Issue:4 Topics: Adolescent; Adult; Analgesics, Non-Narcotic; Antifungal Agents; Antineoplastic Agents; Area Under Curve; Carbamazepine; Cross-Over Studies; Drug Interactions; Female; Half-Life; Humans; Ketoconazole; Lapatinib; Male; Middle Aged; Protein Kinase Inhibitors; Quinazolines; Treatment Outcome; Young Adult	2009
Pomalidomide: evaluation of cytochrome P450 and transporter-mediated drug-drug interaction potential in vitro and in healthy subjects. Journal of clinical pharmacology, 2015, Volume: 55, Issue:2 Topics: Adult; Angiogenesis Inhibitors; Animals; Carbamazepine; Cell Line; Cytochrome P-450 Enzyme System; Drug Interactions; Fluvoxamine; Healthy Volunteers; HEK293 Cells; Humans; Ketoconazole; Male; Membrane Transport Proteins; Middle Aged; Neoplasm Proteins; Swine; Thalidomide; Young Adult	2015
Influence of CYP3A4 induction/inhibition on the pharmacokinetics of vilazodone in healthy subjects. Clinical therapeutics, 2014, Nov-01, Volume: 36, Issue:11 Topics: Adolescent; Adult; Carbamazepine; Cross-Over Studies; Cytochrome P-450 CYP3A Inducers; Cytochrome P-450 CYP3A Inhibitors; Depressive Disorder, Major; Double-Blind Method; Drug Interactions; Female; Healthy Volunteers; Humans; Ketoconazole; Male; Middle Aged; Vilazodone Hydrochloride; Young Adult	2014
Evaluation of Cytochrome P450 (CYP) 3A4-Based Interactions of Levomilnacipran with Ketoconazole, Carbamazepine or Alprazolam in Healthy Subjects. Clinical drug investigation, 2015, Volume: 35, Issue:10 Topics: Adolescent; Adult; Alprazolam; Area Under Curve; Carbamazepine; Cyclopropanes; Cytochrome P-450 CYP3A Inducers; Cytochrome P-450 CYP3A Inhibitors; Delayed-Action Preparations; Drug Interactions; Female; Healthy Volunteers; Humans; Ketoconazole; Male; Middle Aged; Milnacipran; Young Adult	2015
Ibrutinib Dosing Strategies Based on Interaction Potential of CYP3A4 Perpetrators Using Physiologically Based Pharmacokinetic Modeling. Clinical pharmacology and therapeutics, 2016, Volume: 100, Issue:5 Topics: Adenine; Alkynes; Azithromycin; Benzoxazines; Carbamazepine; Cyclopropanes; Cytochrome P-450 CYP3A Inducers; Cytochrome P-450 CYP3A Inhibitors; Drug Dosage Calculations; Drug Interactions; Fluvoxamine; Humans; Ketoconazole; Male; Models, Biological; Piperidines; Pyrazoles; Pyrimidines; Rifampin	2016
Low Potential of Basimglurant to Be Involved in Drug-Drug Interactions: Influence of Non-Michaelis-Menten P450 Kinetics on Fraction Metabolized. The Journal of pharmacology and experimental therapeutics, 2017, Volume: 360, Issue:1 Topics: Adult; Aged; Carbamazepine; Cytochrome P-450 Enzyme System; Drug Interactions; Female; Fluvoxamine; Humans; Imidazoles; Ketoconazole; Kinetics; Male; Middle Aged; Oxidation-Reduction; Pyridines; Young Adult	2017

Other Studies

39 other study(ies) available for carbamazepine and ketoconazole

Article	Year
Cheminformatic models to predict binding affinities to human serum albumin. Journal of medicinal chemistry, 2001, Dec-06, Volume: 44, Issue:25 Topics: Adrenergic beta-Antagonists; Antidepressive Agents, Tricyclic; Chromatography, Affinity; Cyclooxygenase Inhibitors; Databases, Factual; Humans; Hydrophobic and Hydrophilic Interactions; Penicillins; Pharmaceutical Preparations; Protein Binding; Quantitative Structure-Activity Relationship; Reproducibility of Results; Serum Albumin; Steroids	2001
Identification and prediction of promiscuous aggregating inhibitors among known drugs. Journal of medicinal chemistry, 2003, Oct-09, Volume: 46, Issue:21 Topics: Antifungal Agents; beta-Lactamase Inhibitors; Chemical Phenomena; Chemistry, Physical; Chymotrypsin; Enzyme Inhibitors; Kinetics; Light; Malate Dehydrogenase; Models, Molecular; Molecular Conformation; Scattering, Radiation; Structure-Activity Relationship	2003
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling. Current drug discovery technologies, 2004, Volume: 1, Issue:4 Topics: Adverse Drug Reaction Reporting Systems; Artificial Intelligence; Computers; Databases, Factual; Drug Prescriptions; Drug-Related Side Effects and Adverse Reactions; Endpoint Determination; Models, Molecular; Quantitative Structure-Activity Relationship; Software; United States; United States Food and Drug Administration	2004
Chemical genetics reveals a complex functional ground state of neural stem cells. Nature chemical biology, 2007, Volume: 3, Issue:5 Topics: Animals; Cell Survival; Cells, Cultured; Mice; Molecular Structure; Neoplasms; Neurons; Pharmaceutical Preparations; Sensitivity and Specificity; Stem Cells	2007
Prediction and identification of drug interactions with the human ATP-binding cassette transporter multidrug-resistance associated protein 2 (MRP2; ABCC2). Journal of medicinal chemistry, 2008, Jun-12, Volume: 51, Issue:11 Topics: Administration, Oral; Animals; Antineoplastic Agents; Antipsychotic Agents; Antiviral Agents; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Biological Transport; Cell Line; Computer Simulation; Cytochrome P-450 Enzyme System; Drug-Related Side Effects and Adverse Reactions; Estradiol; Humans; Insecta; Liver; Models, Molecular; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Neoplasm Proteins; Pharmaceutical Preparations; Pharmacology; Structure-Activity Relationship	2008
Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1. Journal of medicinal chemistry, 2008, Oct-09, Volume: 51, Issue:19 Topics: Cell Line; Computer Simulation; Drug Design; Gene Expression Profiling; Humans; Hydrogen Bonding; Liver; Molecular Weight; Organic Cation Transporter 1; Pharmaceutical Preparations; Predictive Value of Tests; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Structure-Activity Relationship	2008
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. Chemical research in toxicology, 2010, Volume: 23, Issue:1 Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship	2010
Development of a phospholipidosis database and predictive quantitative structure-activity relationship (QSAR) models. Toxicology mechanisms and methods, 2008, Volume: 18, Issue:2-3 Topics:	2008
Multi-target spectral moment QSAR versus ANN for antiparasitic drugs against different parasite species. Bioorganic & medicinal chemistry, 2010, Mar-15, Volume: 18, Issue:6 Topics: Antiparasitic Agents; Molecular Structure; Neural Networks, Computer; Parasitic Diseases; Quantitative Structure-Activity Relationship; Species Specificity; Thermodynamics	2010
Developing structure-activity relationships for the prediction of hepatotoxicity. Chemical research in toxicology, 2010, Jul-19, Volume: 23, Issue:7 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; Tetracyclines; Thiophenes	2010
Predicting phospholipidosis using machine learning. Molecular pharmaceutics, 2010, Oct-04, Volume: 7, Issue:5 Topics: Animals; Artificial Intelligence; Databases, Factual; Drug Discovery; Humans; Lipidoses; Models, Biological; Phospholipids; Support Vector Machine	2010
A predictive ligand-based Bayesian model for human drug-induced liver injury. Drug metabolism and disposition: the biological fate of chemicals, 2010, Volume: 38, Issue:12 Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands	2010
Predicting hERG activities of compounds from their 3D structures: development and evaluation of a global descriptors based QSAR model. European journal of medicinal chemistry, 2011, Volume: 46, Issue:2 Topics: Computer Simulation; Ether-A-Go-Go Potassium Channels; Humans; Molecular Structure; Organic Chemicals; Quantitative Structure-Activity Relationship	2011
FDA-approved drug labeling for the study of drug-induced liver injury. Drug discovery today, 2011, Volume: 16, Issue:15-16 Topics: Animals; Benchmarking; Biomarkers, Pharmacological; Chemical and Drug Induced Liver Injury; Drug Design; Drug Labeling; Drug-Related Side Effects and Adverse Reactions; Humans; Pharmaceutical Preparations; Reproducibility of Results; United States; United States Food and Drug Administration	2011
In vitro inhibition of the bile salt export pump correlates with risk of cholestatic drug-induced liver injury in humans. Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:1 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Cholestasis; Drug-Related Side Effects and Adverse Reactions; Humans; Insecta; Rats; Risk Factors	2012
Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions. Journal of medicinal chemistry, 2012, May-24, Volume: 55, Issue:10 Topics: Atorvastatin; Biological Transport; Drug Interactions; Estradiol; Estrone; HEK293 Cells; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Least-Squares Analysis; Liver; Liver-Specific Organic Anion Transporter 1; Models, Molecular; Multivariate Analysis; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Protein Isoforms; Pyrroles; Solute Carrier Organic Anion Transporter Family Member 1B3; Structure-Activity Relationship; Transfection	2012
Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds. Chemical research in toxicology, 2012, Oct-15, Volume: 25, Issue:10 Topics: Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Decision Trees; Drug Evaluation, Preclinical; Drug-Related Side Effects and Adverse Reactions; Glutathione; Humans; Liver; Pharmaceutical Preparations; Protein Binding	2012
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification. Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:12 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Humans; Quantitative Structure-Activity Relationship	2012
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development. Toxicological sciences : an official journal of the Society of Toxicology, 2013, Volume: 136, Issue:1 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests	2013
A high-throughput cell-based method to predict the unbound drug fraction in the brain. Journal of medicinal chemistry, 2014, Apr-10, Volume: 57, Issue:7 Topics: Animals; Brain; Dialysis; HEK293 Cells; High-Throughput Screening Assays; Humans; Pharmaceutical Preparations; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization	2014
Orally bioavailable 6-chloro-7-methoxy-4(1H)-quinolones efficacious against multiple stages of Plasmodium. Journal of medicinal chemistry, 2014, Nov-13, Volume: 57, Issue:21 Topics: Animals; Antimalarials; Humans; Inhibitory Concentration 50; Malaria; Mice; Microsomes, Liver; Parasitemia; Plasmodium; Plasmodium berghei; Quinolones; Structure-Activity Relationship	2014
Design, synthesis and biological evaluation of new hybrid anticonvulsants derived from N-benzyl-2-(2,5-dioxopyrrolidin-1-yl)propanamide and 2-(2,5-dioxopyrrolidin-1-yl)butanamide derivatives. Bioorganic & medicinal chemistry, 2015, May-15, Volume: 23, Issue:10 Topics: Amides; Animals; Anticonvulsants; Benzylamines; Convulsants; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Design; Electroshock; Humans; Imidazoles; Male; Mice; Microsomes, Liver; Molecular Structure; Motor Activity; Pentylenetetrazole; Propionates; Pyrrolidines; Rotarod Performance Test; Seizures; Small Molecule Libraries; Structure-Activity Relationship	2015
Design, synthesis, and anticonvulsant activity of new hybrid compounds derived from 2-(2,5-dioxopyrrolidin-1-yl)propanamides and 2-(2,5-dioxopyrrolidin-1-yl)butanamides. Journal of medicinal chemistry, 2015, Jul-09, Volume: 58, Issue:13 Topics: Animals; Anticonvulsants; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Design; Electroshock; HEK293 Cells; Humans; Mice; Models, Molecular; Molecular Structure; Motor Activity; Piperazines; Seizures; Structure-Activity Relationship; Succinimides	2015
Interaction of azoles with rifampin, phenytoin, and carbamazepine: in vitro and clinical observations. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 1992, Volume: 14, Issue:1 Topics: Adult; Aged; Antifungal Agents; Azoles; Carbamazepine; Coccidioides; Cryptococcus neoformans; Drug Interactions; Drug Therapy, Combination; Female; Fluconazole; Humans; Itraconazole; Ketoconazole; Malassezia; Male; Middle Aged; Mycoses; Phenytoin; Rifampin	1992
An investigation of the formation of cytotoxic, protein-reactive and stable metabolites from carbamazepine in vitro. Biochemical pharmacology, 1992, Apr-15, Volume: 43, Issue:8 Topics: Animals; Ascorbic Acid; Biotransformation; Carbamazepine; Cell Death; Cytosol; Epoxide Hydrolases; Glutathione; Humans; Ketoconazole; Lymphocytes; Mice; Microsomes, Liver; Models, Chemical; Phenobarbital; Proteins	1992
Saccharomyces cerevisiae: an alternative source for human microsomal liver enzymes and its use in drug interaction studies. Toxicology, 1993, Oct-05, Volume: 82, Issue:1-3 Topics: Anticonvulsants; Benzoflavones; Carbamazepine; Cloning, Molecular; Cytochrome P-450 CYP1A2; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; DNA, Complementary; Drug Interactions; Epoxide Hydrolases; Humans; Ketoconazole; Microsomes, Liver; Oxidoreductases, N-Demethylating; Saccharomyces cerevisiae; Valproic Acid	1993
Elevation of plasma carbamazepine concentrations by ketoconazole in patients with epilepsy. Therapeutic drug monitoring, 1997, Volume: 19, Issue:5 Topics: Adult; Antifungal Agents; Carbamazepine; Drug Interactions; Drug Monitoring; Epilepsy; Female; Humans; Ketoconazole; Male; Middle Aged	1997
Vulvar vestibulitis syndrome: an often unrecognized cause of dyspareunia. The Australian & New Zealand journal of obstetrics & gynaecology, 1999, Volume: 39, Issue:1 Topics: Adolescent; Adult; Aged; Amitriptyline; Analgesics, Non-Narcotic; Antidepressive Agents, Tricyclic; Antifungal Agents; Candidiasis, Vulvovaginal; Carbamazepine; Dyspareunia; Female; Follow-Up Studies; Humans; Hyperesthesia; Ketoconazole; Middle Aged; Prospective Studies; Risk Factors; Syndrome; Treatment Outcome; Vulvitis	1999
Chronic administration of verapamil, ketoconazole and carbamazepine: impact on immunological parameters. International journal of pharmaceutics, 2002, May-15, Volume: 238, Issue:1-2 Topics: Animals; Anticonvulsants; Antifungal Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Blood Cell Count; Body Weight; Calcium Channel Blockers; Carbamazepine; Cytochrome P-450 Enzyme System; Immunity; Immunity, Cellular; Ketoconazole; Male; Mice; Monocytes; Verapamil	2002
Comparison of mouse and rat cytochrome P450-mediated metabolism in liver and intestine. Drug metabolism and disposition: the biological fate of chemicals, 2006, Volume: 34, Issue:6 Topics: Animals; Carbamazepine; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Enzyme Inhibitors; Hydroxytestosterones; In Vitro Techniques; Intestinal Mucosa; Intestines; Ketoconazole; Liver; Male; Membrane Proteins; Mice; Mice, Nude; Microsomes; Midazolam; Oxidoreductases; Rats; Rats, Sprague-Dawley; RNA, Messenger; Substrate Specificity	2006
Characterisation of zuclopenthixol metabolism by in vitro and therapeutic drug monitoring studies. Acta psychiatrica Scandinavica, 2010, Volume: 122, Issue:6 Topics: Adult; Antidepressive Agents, Second-Generation; Antifungal Agents; Antimalarials; Antimanic Agents; Antipsychotic Agents; Carbamazepine; Clopenthixol; Cytochrome P-450 Enzyme System; Dose-Response Relationship, Drug; Drug Interactions; Drug Monitoring; Female; Fluoxetine; Humans; In Vitro Techniques; Ketoconazole; Male; Methotrimeprazine; Microsomes, Liver; Middle Aged; Paroxetine; Quinidine	2010
Mouse precision-cut liver slices as an ex vivo model to study idiosyncratic drug-induced liver injury. Chemical research in toxicology, 2012, Sep-17, Volume: 25, Issue:9 Topics: Animals; Benzodiazepines; Biomarkers; Carbamazepine; Cell Survival; Chemical and Drug Induced Liver Injury; Chemokines; Chromans; Clozapine; Cytokines; Diclofenac; Drug Synergism; Female; Glutathione; Granulocyte Colony-Stimulating Factor; Granulocyte-Macrophage Colony-Stimulating Factor; In Vitro Techniques; Ketoconazole; Lipopolysaccharides; Mice; Mice, Inbred C57BL; Nitrogen Oxides; Olanzapine; Pyrimidines; Thiazolidinediones; Triazoles; Troglitazone; Voriconazole	2012
Sertraline-induced potentiation of the CYP3A4-dependent neurotoxicity of carbamazepine: an in vitro study. Epilepsia, 2015, Volume: 56, Issue:3 Topics: Acetylcysteine; Adenylate Kinase; Anticonvulsants; Brain; Carbamazepine; Cell Death; Cells, Cultured; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Dopaminergic Neurons; Fetus; Gene Expression Regulation; Glutathione; Humans; Ketoconazole; Microsomes, Liver; Nitrites; Selective Serotonin Reuptake Inhibitors; Sertraline; Time Factors	2015
Carbamazepine-Induced Liver Injury Requires CYP3A-Mediated Metabolism and Glutathione Depletion in Rats. Drug metabolism and disposition: the biological fate of chemicals, 2015, Volume: 43, Issue:7 Topics: Alanine Transaminase; Animals; Anti-Bacterial Agents; Antifungal Agents; Buthionine Sulfoximine; Carbamazepine; Chemical and Drug Induced Liver Injury; Cytochrome P-450 CYP3A; Enzyme Induction; Enzyme Inhibitors; Glutathione; Hydroxylation; Ketoconazole; Liver; Male; Microsomes, Liver; Rats; Rats, Inbred F344; Troleandomycin	2015
Evaluation of the Effects of Ketoconazole and Voriconazole on the Pharmacokinetics of Oxcarbazepine and Its Main Metabolite MHD in Rats by UPLC-MS-MS. Journal of chromatographic science, 2016, Volume: 54, Issue:3 Topics: Animals; Anticonvulsants; Antifungal Agents; Biotransformation; Carbamazepine; Chromatography, High Pressure Liquid; Diazepam; Drug Combinations; Drug Interactions; Ketoconazole; Limit of Detection; Male; Oxcarbazepine; Prodrugs; Rats; Rats, Sprague-Dawley; Reference Standards; Reproducibility of Results; Tandem Mass Spectrometry; Voriconazole	2016
Exploring the Carbamazepine Interaction with Human Pregnane X Receptor and Effect on ABCC2 Using in Vitro and in Silico Approach. Pharmaceutical research, 2017, Volume: 34, Issue:7 Topics: Active Transport, Cell Nucleus; Anticonvulsants; Binding, Competitive; Carbamazepine; Cell Nucleus; Computer Simulation; Hep G2 Cells; Humans; Ketoconazole; Ligands; Molecular Docking Simulation; Molecular Dynamics Simulation; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Mutation; Phloroglucinol; Pregnane X Receptor; Protein Binding; Receptors, Steroid; RNA Interference; Terpenes	2017
Functionalized PEG-PLA nanoparticles for brain targeted delivery of ketoconazole contribute to pregnane X receptor overexpressing in drug-resistant epilepsy. Epilepsy research, 2022, Volume: 186 Topics: Animals; Brain; Carbamazepine; Drug Resistant Epilepsy; Epilepsy; Kainic Acid; Ketoconazole; Mice; Micelles; Nanoparticles; Polyethylene Glycols; Pregnane X Receptor	2022
Development of a cell viability assay to assess drug metabolite structure-toxicity relationships. Bioorganic & medicinal chemistry letters, 2016, 08-15, Volume: 26, Issue:16 Topics: Adenosine Triphosphate; Benzbromarone; Cell Line; Cell Survival; Chromans; Cytochrome P-450 CYP2C9; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Humans; Pharmaceutical Preparations; Thiazolidinediones; Troglitazone	2016
Increasing the Endoplasmic Reticulum Pool of the F508del Allele of the Cystic Fibrosis Transmembrane Conductance Regulator Leads to Greater Folding Correction by Small Molecule Therapeutics. PloS one, 2016, Volume: 11, Issue:10 Topics: Alleles; Benzoates; Cells, Cultured; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; Endoplasmic Reticulum; Furans; Gene Deletion; HEK293 Cells; HeLa Cells; High-Throughput Screening Assays; Humans; Hydroxamic Acids; Microscopy, Fluorescence; Protein Folding; Protein Structure, Tertiary; Pyrazoles; RNA, Messenger; Small Molecule Libraries; Ubiquitination; Vorinostat	2016