carbamazepine and efavirenz

carbamazepine has been researched along with efavirenz in 14 studies

Research

Studies (14)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	7 (50.00)	29.6817
2010's	6 (42.86)	24.3611
2020's	1 (7.14)	2.80

Authors

Authors	Studies
Ahlin, G; Artursson, P; Bergström, CA; Gustavsson, L; Karlsson, J; Larsson, R; Matsson, P; Norinder, U; Pedersen, JM	1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A	1
Artursson, P; Haglund, U; Karlgren, M; Kimoto, E; Lai, Y; Norinder, U; Vildhede, A; Wisniewski, JR	1
Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ	1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K	1
Burman, W; Orr, L	1
Best, B; Capparelli, E; Goicoechea, M; Haubrich, R	1
Faucette, SR; LeCluyse, EL; Moore, R; Negishi, M; Omiecinski, CJ; Sueyoshi, T; Wang, H; Zhang, TC	1
Damle, B; Grasela, DM; Ji, P; Kaul, S; Unger, SE; Xie, J	1
Hayashi, M; Morrissey, K; Pan, Y; Shou, M; Skiles, GL; Xu, L; Xu, Y	1
Grasela, DM; Kaul, S; Nandy, P; Pfister, M; Zhu, M	1
De Jong, J; de Zwart, L; Mannaert, E; Monshouwer, M; Snoeys, J; Sukbuntherng, J	1
Burger, DM; Drenth, JPH; Jacobs, TG; Khoo, SH; Pranger, AD; van Crevel, R	1
Chaturvedula, A; Cicali, B; Cristofoletti, R; Hoechel, J; Lingineni, K; Schmidt, S; Vozmediano, V; Wendl, T; Wiesinger, H	1

Reviews

1 review(s) available for carbamazepine and efavirenz

Article	Year
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans. Drug discovery today, 2016, Volume: 21, Issue:4 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk	2016

Trials

2 trial(s) available for carbamazepine and efavirenz

Article	Year
Pharmacokinetic interaction between efavirenz and carbamazepine after multiple-dose administration in healthy subjects. Journal of clinical pharmacology, 2008, Volume: 48, Issue:8 Topics: Adult; Alkynes; Anti-HIV Agents; Anticonvulsants; Area Under Curve; Benzoxazines; Biotransformation; Carbamazepine; Chromatography, High Pressure Liquid; Cross-Over Studies; Cyclopropanes; Drug Interactions; Female; Half-Life; Humans; Male; Middle Aged; Sample Size	2008
Ibrutinib Dosing Strategies Based on Interaction Potential of CYP3A4 Perpetrators Using Physiologically Based Pharmacokinetic Modeling. Clinical pharmacology and therapeutics, 2016, Volume: 100, Issue:5 Topics: Adenine; Alkynes; Azithromycin; Benzoxazines; Carbamazepine; Cyclopropanes; Cytochrome P-450 CYP3A Inducers; Cytochrome P-450 CYP3A Inhibitors; Drug Dosage Calculations; Drug Interactions; Fluvoxamine; Humans; Ketoconazole; Male; Models, Biological; Piperidines; Pyrazoles; Pyrimidines; Rifampin	2016

Article

Year

Pharmacokinetic interaction between efavirenz and carbamazepine after multiple-dose administration in healthy subjects.

Journal of clinical pharmacology, 2008, Volume: 48, Issue:8

Topics: Adult; Alkynes; Anti-HIV Agents; Anticonvulsants; Area Under Curve; Benzoxazines; Biotransformation; Carbamazepine; Chromatography, High Pressure Liquid; Cross-Over Studies; Cyclopropanes; Drug Interactions; Female; Half-Life; Humans; Male; Middle Aged; Sample Size

2008

Ibrutinib Dosing Strategies Based on Interaction Potential of CYP3A4 Perpetrators Using Physiologically Based Pharmacokinetic Modeling.

Clinical pharmacology and therapeutics, 2016, Volume: 100, Issue:5

Topics: Adenine; Alkynes; Azithromycin; Benzoxazines; Carbamazepine; Cyclopropanes; Cytochrome P-450 CYP3A Inducers; Cytochrome P-450 CYP3A Inhibitors; Drug Dosage Calculations; Drug Interactions; Fluvoxamine; Humans; Ketoconazole; Male; Models, Biological; Piperidines; Pyrazoles; Pyrimidines; Rifampin

2016

Other Studies

11 other study(ies) available for carbamazepine and efavirenz

Article	Year
Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1. Journal of medicinal chemistry, 2008, Oct-09, Volume: 51, Issue:19 Topics: Cell Line; Computer Simulation; Drug Design; Gene Expression Profiling; Humans; Hydrogen Bonding; Liver; Molecular Weight; Organic Cation Transporter 1; Pharmaceutical Preparations; Predictive Value of Tests; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Structure-Activity Relationship	2008
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. Chemical research in toxicology, 2010, Volume: 23, Issue:1 Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship	2010
Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions. Journal of medicinal chemistry, 2012, May-24, Volume: 55, Issue:10 Topics: Atorvastatin; Biological Transport; Drug Interactions; Estradiol; Estrone; HEK293 Cells; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Least-Squares Analysis; Liver; Liver-Specific Organic Anion Transporter 1; Models, Molecular; Multivariate Analysis; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Protein Isoforms; Pyrroles; Solute Carrier Organic Anion Transporter Family Member 1B3; Structure-Activity Relationship; Transfection	2012
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development. Toxicological sciences : an official journal of the Society of Toxicology, 2013, Volume: 136, Issue:1 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests	2013
Carbamazepine toxicity after starting combination antiretroviral therapy including ritonavir and efavirenz. AIDS (London, England), 2000, Dec-01, Volume: 14, Issue:17 Topics: Alkynes; Anti-HIV Agents; Anticonvulsants; Antiretroviral Therapy, Highly Active; Benzoxazines; Carbamazepine; Cyclopropanes; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Dose-Response Relationship, Drug; Drug Interactions; Female; HIV Infections; HIV Protease Inhibitors; Humans; Middle Aged; Mixed Function Oxygenases; Oxazines; Reverse Transcriptase Inhibitors; Ritonavir; Seizures	2000
Concurrent use of efavirenz and oxcarbazepine may not affect efavirenz plasma concentrations. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2006, Jul-01, Volume: 43, Issue:1 Topics: Adult; Alkynes; Anti-HIV Agents; Anticonvulsants; Benzoxazines; Bipolar Disorder; Carbamazepine; Cyclopropanes; Cytochrome P-450 Enzyme System; Drug Interactions; Drug Monitoring; HIV Infections; Humans; Male; Mental Disorders; Nervous System Diseases; Oxazines; Oxcarbazepine; Treatment Failure; Viral Load	2006
Relative activation of human pregnane X receptor versus constitutive androstane receptor defines distinct classes of CYP2B6 and CYP3A4 inducers. The Journal of pharmacology and experimental therapeutics, 2007, Volume: 320, Issue:1 Topics: Alkynes; Animals; Aryl Hydrocarbon Hydroxylases; Benzoxazines; Carbamazepine; Cells, Cultured; Constitutive Androstane Receptor; Cyclopropanes; Cytochrome P-450 CYP2B6; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Enzyme Induction; Gene Expression Regulation, Enzymologic; Hepatocytes; Humans; Mice; Nevirapine; Oxazines; Oxidoreductases, N-Demethylating; Pregnane X Receptor; Protein Transport; Receptors, Cytoplasmic and Nuclear; Receptors, Steroid; Transcription Factors; Transcriptional Activation	2007
Modeling, prediction, and in vitro in vivo correlation of CYP3A4 induction. Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:11 Topics: Adult; Alkynes; Benzoxazines; Bosentan; Carbamazepine; Cells, Cultured; Cyclopropanes; Cytochrome P-450 CYP3A; Dose-Response Relationship, Drug; Enzyme Induction; Female; Hepatocytes; Humans; Models, Biological; Models, Chemical; Predictive Value of Tests; Substrate Specificity; Sulfonamides	2008
Model-based approach to characterize efavirenz autoinduction and concurrent enzyme induction with carbamazepine. Antimicrobial agents and chemotherapy, 2009, Volume: 53, Issue:6 Topics: Adolescent; Adult; Alkynes; Area Under Curve; Aryl Hydrocarbon Hydroxylases; Benzoxazines; Carbamazepine; Cyclopropanes; Cytochrome P-450 CYP2B6; Cytochrome P-450 CYP3A; Drug Interactions; Enzyme Induction; Female; Humans; Male; Middle Aged; Models, Biological; Oxidoreductases, N-Demethylating	2009
Carbamazepine intervention in a patient with efavirenz-induced liver injury. AIDS (London, England), 2019, 05-01, Volume: 33, Issue:6 Topics: Alanine Transaminase; Alkynes; Anti-HIV Agents; Aspartate Aminotransferases; Benzoxazines; Bilirubin; Carbamazepine; Chemical and Drug Induced Liver Injury; Cyclopropanes; Cytochrome P-450 CYP2B6 Inducers; Cytochrome P-450 CYP3A Inducers; Humans; Male; Middle Aged; Treatment Outcome	2019
Quantitative Assessment of Levonorgestrel Binding Partner Interplay and Drug-Drug Interactions Using Physiologically Based Pharmacokinetic Modeling. CPT: pharmacometrics & systems pharmacology, 2021, Volume: 10, Issue:1 Topics: Adult; Alkynes; Benzoxazines; Body Mass Index; Carbamazepine; Clarithromycin; Computer Simulation; Contraceptives, Oral, Combined; Cyclopropanes; Cytochrome P-450 CYP3A Inducers; Cytochrome P-450 CYP3A Inhibitors; Drug Combinations; Drug Interactions; Ethinyl Estradiol; Female; Humans; Itraconazole; Levonorgestrel; Models, Biological; Obesity; Rifampin; Sex Hormone-Binding Globulin	2021