carbamazepine has been researched along with caffeine in 142 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 15 (10.56) | 18.7374 |
| 1990's | 13 (9.15) | 18.2507 |
| 2000's | 29 (20.42) | 29.6817 |
| 2010's | 70 (49.30) | 24.3611 |
| 2020's | 15 (10.56) | 2.80 |
| Authors | Studies |
|---|---|
| Creveling, CR; Daly, JW; Lewandowski, GA; McNeal, ET | 1 |
| Blake, JF; Curatolo, WJ; Lombardo, F | 1 |
| Topliss, JG; Yoshida, F | 1 |
| Abraham, MH; Gao, F; Lombardo, F; Shalaeva, MY; Tupper, KA | 1 |
| Gao, F; Lombardo, F; Shalaeva, MY; Tupper, KA | 1 |
| Alvarez-Pedraglio, A; Colmenarejo, G; Lavandera, JL | 1 |
| Faassen, F; Spanings, H; Vogel, G; Vromans, H | 1 |
| Bellows, DS; Clarke, ID; Diamandis, P; Dirks, PB; Graham, J; Jamieson, LG; Ling, EK; Sacher, AG; Tyers, M; Ward, RJ; Wildenhain, J | 1 |
| Andricopulo, AD; Moda, TL; Montanari, CA | 1 |
| Giralt, E; Malakoutikhah, M; Teixidó, M | 1 |
| Ahlin, G; Artursson, P; Bergström, CA; Gustavsson, L; Karlsson, J; Larsson, R; Matsson, P; Norinder, U; Pedersen, JM | 1 |
| Ahman, M; Holmén, AG; Wan, H | 1 |
| Botta, M; Dreassi, E; Falchi, F; Maga, G; Santucci, A; Schenone, S; Zizzari, AT | 1 |
| Chen, L; He, Z; Li, H; Liu, J; Liu, X; Sui, X; Sun, J; Wang, Y; Zhang, W | 1 |
| Conradi, R; Lee, PH; Shanmugasundaram, V | 1 |
| Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
| Choi, SS; Contrera, JF; Hastings, KL; Kruhlak, NL; Sancilio, LF; Weaver, JL; Willard, JM | 1 |
| Giralt, E; Malakoutikhah, M; Prades, R; Teixidó, M | 1 |
| Avdeef, A; Tam, KY | 1 |
| Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ | 1 |
| Glen, RC; Lowe, R; Mitchell, JB | 1 |
| Ekins, S; Williams, AJ; Xu, JJ | 1 |
| Boriss, H; Braggio, S; Corbioli, S; Fontana, S; Helmdach, L; Longhi, R; Schiller, J; Vinco, F | 1 |
| Sen, S; Sinha, N | 1 |
| Annand, R; Gozalbes, R; Jacewicz, M; Pineda-Lucena, A; Tsaioun, K | 1 |
| Honda, K; Izumi, T; Miyaji, Y; Nakayama, S; Okazaki, O; Okudaira, N; Shiosakai, K; Sugiyama, D; Suzuki, W; Takakusa, H; Watanabe, A | 1 |
| Barber, S; Dew, TP; Farrell, TL; Poquet, L; Williamson, G | 1 |
| Artursson, P; Haglund, U; Karlgren, M; Kimoto, E; Lai, Y; Norinder, U; Vildhede, A; Wisniewski, JR | 1 |
| Ambroso, JL; Ayrton, AD; Baines, IA; Bloomer, JC; Chen, L; Clarke, SE; Ellens, HM; Harrell, AW; Lovatt, CA; Reese, MJ; Sakatis, MZ; Taylor, MA; Yang, EY | 1 |
| Cantin, LD; Chen, H; Kenna, JG; Noeske, T; Stahl, S; Walker, CL; Warner, DJ | 1 |
| Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ | 1 |
| Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K | 1 |
| Campillo, NE; Cañada, FJ; Canales, A; Carvalho, I; Chierrito, TPC; Martinez, A; Martínez-Gonzalez, L; Pedersoli-Mantoani, S; Perez, C; Pérez, DI; Roca, C; Sebastian-Pérez, V | 1 |
| Borges, F; Chavarria, D; Fernandes, C; Gil-Martins, E; Oliveira, PJ; Remião, F; Silva, C; Silva, R; Silva, T; Silva, V; Soares, P | 1 |
| Behnam, MAM; Bock, J; Graf, D; Klein, CD; Kühl, N; Leuthold, MM | 1 |
| Behnam, MAM; Klein, CD; Kühl, N; Leuthold, MM | 1 |
| Karmen, A; Lehrer, M | 1 |
| Elphick, M; Godfrey, PP; Powell, T; Taghavi, Z | 1 |
| Haginaka, J; Kimura, Y; Wakai, J; Yasuda, H | 1 |
| Baty, C; Jambou, J; Leducq, B; Richard, L | 1 |
| Büchsel, R; Kohl, D; Kreiten, K; Matern, S; Wietholtz, H; Zysset, T | 1 |
| Caporali, MG; Popoli, P; Scotti de Carolis, A | 1 |
| David, J; Joseph, T; Kulkarni, C | 1 |
| Stein, MB; Uhde, TW | 1 |
| Clark, M; Post, RM | 1 |
| Fujiwara, Y; Kazahaya, Y; Otsuki, S; Sandyk, R; Takeda, T | 1 |
| Baudry, M; Jones, RS; Olpe, HR | 1 |
| Benedetti, M; Popoli, P; Scotti de Carolis, A | 1 |
| Caporali, MG; de Carolis, AS; Popoli, P | 1 |
| Marangos, PJ; Patel, J; Post, RM; Weiss, SR | 1 |
| Binns, PM; Ericsson, AD; Meyer, JS; Vulpe, M | 1 |
| Anderson, SM; Daly, JW; Padgett, W; Weir, RL | 1 |
| Bingmann, D; Düsing, R; Grunze, H; Liu, Z; Mayer, A; Schirrmacher, K; Walden, J | 1 |
| Beckmann, H; Berger, W; Deckert, J; Heckers, S; Heinsen, H; Kleopa, K; Ransmayr, G; Riederer, P | 1 |
| Borowicz, K; Czuczwar, SJ; Gasior, M; Kleinrok, Z | 1 |
| Kaneko, S; Kawata, Y; Kiryu, K; Mizuno, K; Okada, M; Tasaki, H; Wada, K | 1 |
| Choonara, I; Parker, AC; Preston, T; Pritchard, P | 1 |
| Akimoto, T; Mashimoto, S; Suetsugi, M; Ushijima, I; Watanabe, K; Yamada, M | 1 |
| David, J; Joseph, T; Kulkarni, C; Vaz, J | 1 |
| Kaneko, S; Okada, M | 1 |
| Gibson, GG; Goldfarb, PS; Gray, TJ; Ogg, MS; Tarbit, M; Williams, JM | 1 |
| Pons, G; Rey, E | 1 |
| Bošković, B; Prostran, MŠ; Stepanović-Petrović, RM; Tomić, MA; Ugrešić, N; Vučković, SM | 2 |
| Brain, RA; Hanson, ML; Johnson, DJ; Lam, MW; Mabury, SA; Richards, SM; Sanderson, H; Sibley, PK; Solomon, KR; Young, C | 1 |
| Lawrence, JR; Neu, TR; Swerhone, GD; Wassenaar, LI | 1 |
| Metcalfe, CD; Miao, XS; Yang, JJ | 1 |
| Boskovic, B; Prostran, M; Stepanovic-Petrovic, R; Tomic, M; Ugresic, N; Vuckovic, S | 1 |
| André, C; Blaise, C; Gagné, F; Salazar, M | 1 |
| Johnson, TN; Rostami-Hodjegan, A; Tucker, GT | 1 |
| Adriaensen, J; Augustijns, P; Brewster, ME; Mackie, C; Melis, A; Mensch, J; Noppe, M | 1 |
| Alsenz, J; Grassmann, O; Wyttenbach, N | 1 |
| Cederberg, J; Dahl, ML; Karlsson, MO; Magnusson, MO; Sandström, R | 1 |
| Błaszczyk, B; Chrościńska-Krawczyk, M; Czuczwar, SJ; Jankiewicz, K | 1 |
| Clinton, PW; Gielen, GJ; Greenfield, LG; van den Heuvel, MR | 1 |
| Benotti, MJ; Brownawell, BJ | 1 |
| Kakidas, C; Taylor, LS; Wikström, H | 1 |
| Gift, AD; Luedeman, L; Luner, PE; Taylor, LS | 1 |
| Agüera, A; Fernández-Alba, AR; Klamerth, N; Malato, S; Maldonado, MI; Rizzo, L | 1 |
| Fredholm, BB; Reid, AR; Sawynok, J | 1 |
| Alsberg, T; Filipovic, M; Magnér, J | 1 |
| Badruzzaman, M; Eaton, A; Haghani, AW; Jacangelo, JG; Oppenheimer, J | 1 |
| Ignatov, IuD; Liubashina, OA; Panteleev, SS; Sokolov, AIu; Syrovaia, AO; Zviagintseva, TV | 1 |
| Acuña, J; Gómez, E; Murillo, M; Perez, G; Spongberg, AL; Umaña, G; Vargas, J; Witter, JD | 1 |
| Aboulfadl, K; Deschamps, G; Dorner, S; Payment, P; Prévost, M; Sauvé, S | 1 |
| Geyer, T; Hillebrand, O; Licha, T; Nödler, K; Sauter, M | 1 |
| Kuroda, K; Murakami, M; Muramatsu, Y; Oguma, K; Takada, H; Takizawa, S | 1 |
| Kühne, S; Steinert, M; Untucht, C; Wätzig, H | 1 |
| Gersberg, RM; Hua, T; Tan, SK; Tuan, NA; Zhang, DQ; Zhu, J | 1 |
| Potera, C | 1 |
| Alonso, E; Aparicio, I; Camacho-Muñoz, MA; Martín, J; Santos, JL | 1 |
| Gersberg, RM; Hua, T; Jinadasa, KB; Tan, SK; Zhang, DQ; Zhu, J | 1 |
| Bahlmann, A; Carvalho, JJ; Panne, U; Schneider, RJ; Weller, MG | 1 |
| Cabrera-Lafaurie, WA; Hernández-Maldonado, AJ; Román, FR | 2 |
| Hirakura, Y; Terada, K; Teramura, T; Yamashita, H; Yuda, M | 1 |
| Jeanray, N; Martial, JA; Muller, M; Piot, A; Pruvot, B; Quiroz, Y; Voncken, A | 1 |
| Carriquiriborde, P; Elorriaga, Y; Marino, DJ; Ronco, AE | 1 |
| Barndõk, H; Blanco, A; Campo, P; Dionysiou, DD; Han, C; Hermosilla, D; Peláez, M; Platten, WE | 1 |
| Gardinali, PR; Wang, J | 1 |
| Chen, F; Chen, H; Fu, W; Luo, W; Meng, F; Xie, Y; Yang, X; Ye, T; Young, K | 1 |
| Hermsen, SA; Piersma, AH; Pronk, TE; van den Brandhof, EJ; van der Ven, LT | 1 |
| Aguirre-Martínez, GV; Buratti, S; DelValls, AT; Fabbr, E; Martín-Díaz, ML | 1 |
| Hu, J; Li, J; Ong, SL; Tran, NH | 1 |
| Fang, MD; Jiang, JJ; Lee, CL | 1 |
| Martínez, F; Melero, JA; Molina, R; Vasiliadou, IA | 1 |
| Carriere, JT; Chan, E; Dabros, M; Larkin, PJ; Sarsfield, B; Smith, BC | 1 |
| Mahugo-Santana, C; Montesdeoca-Esponda, S; Santana-Rodríguez, JJ; Sosa-Ferrera, Z | 1 |
| Licha, T; Nödler, K; Tsakiri, M | 1 |
| Dong, P; Huang, Z; Lang, T; Li, Y; Lin, L; Lu, M; Wu, C | 1 |
| Baran, N; Lapworth, DJ; Manamsa, K; Stuart, ME; Talbot, J | 1 |
| Gasser, G; Gerstl, Z; Ronen, D; Weisbrod, N; Zentner, E | 1 |
| Aguirre-Martínez, GV; DelValls, AT; Laura Martín-Díaz, M | 1 |
| Aguirre-Martínez, GV; DelValls, TA; Martín-Díaz, ML | 1 |
| Cimetière, N; Fallou, H; Giraudet, S; Le Cloirec, P; Wolbert, D | 1 |
| Almeida, Â; Calisto, V; Correia, J; Esteves, VI; Figueira, E; Freitas, R; Pires, A; Schneider, RJ; Soares, AM | 1 |
| Almeida, CM; Benoliel, MJ; Cardoso, VV; de Jesus Gaffney, V; Loureiro, M; Mota-Filipe, H; Pinto, RA; Thiemermann, C | 1 |
| de Bustamante, I; Herrera López, S; Martínez-Hernández, V; Meffe, R | 1 |
| Almeida, Â; Calisto, V; Esteves, VI; Figueira, E; Freitas, R; Pires, A; Schneider, RJ; Soares, AM; Wrona, FJ | 1 |
| Kiguchi, O; Kobayashi, T; Sato, G | 1 |
| Ali, R; Bodmeier, R; Dashevsky, A | 1 |
| Mamba, BB; Msagati, TA; Nyoni, H; Wanda, EM | 1 |
| Groza, LG; Hebig, KH; Ptacek, CJ; Sabourin, MJ; Scheytt, TJ | 1 |
| de Bustamante, I; Kohfahl, C; Martínez-Hernández, V; Meffe, R | 1 |
| Coutinho, JAP; Dinis, TBV; Esteves, VI; Freire, MG; Lima, DLD; Passos, H; Sousa, ACA | 1 |
| Aguirre-Martínez, GV; André, C; Gagné, F; Martín-Díaz, LM | 1 |
| Björnmalm, M; Caruso, F; Hata, Y; Ju, Y; Rahim, MA | 1 |
| Amat, AM; Arques, A; Gomis, J; Marin, ML; Martinez-Haya, R; Miranda, MA | 1 |
| Nagy, S; Pál, S; Salem, A; Széchenyi, A | 1 |
| Carl, P; Gregório, BJR; Hoffmann, K; Lehmann, A; Rurack, K; Sarma, D; Schneider, RJ | 1 |
| Ali, R; Bodmeier, R; Chaerunisaa, AY; Körber, M | 1 |
| Brenčič, M; Koroša, A; Mali, N | 1 |
| Coates, LJ; Gooley, AA; Haddad, PR; Lam, SC; Paull, B; Wirth, HJ | 1 |
| Do, QTT; Otaki, M; Otaki, Y; Sanjeewa, IW; Tushara, C | 1 |
| Correia, AT; Guimarães, LL; Roveri, V; Toma, W | 2 |
| Correia, AT; de Oliveira, TMN; Guimarães, LL; Pisetta, AM; Roveri, V | 1 |
| Dudziak, M; Kudlek, E; Lempart-Rapacewicz, A | 1 |
| Cao, X; Lu, Y; Song, S; Wang, C; Xiu, C; Zhang, M | 1 |
| Li, J; Liu, H; Meng, Y; Wang, X; Zhang, T | 1 |
| Boni, MR; Cecchini, G; Ceci, C; Chiavola, A; Di Marcantonio, C; Frugis, A; Gioia, V; Leoni, S; Spizzirri, M | 1 |
| Masís-Mora, M; Méndez-Rivera, M; Montiel-Mora, JR; Ramírez-Morales, D; Rodríguez-Rodríguez, CE | 1 |
2 review(s) available for carbamazepine and caffeine
| Article | Year |
|---|---|
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk | 2016 |
[Caffeine and antiepileptic drugs: experimental and clinical data].
Topics: Animals; Anticonvulsants; Caffeine; Carbamazepine; Dose-Response Relationship, Drug; Drug Interactions; Electroshock; Humans; Lamotrigine; Mice; Nipecotic Acids; Phenobarbital; Phenytoin; Seizures; Tiagabine; Triazines; Valproic Acid | 2007 |
1 trial(s) available for carbamazepine and caffeine
| Article | Year |
|---|---|
Influence of caffeine on pharmacokinetic profile of sodium valproate and carbamazepine in normal human volunteers.
Topics: Anticonvulsants; Caffeine; Carbamazepine; Cross-Over Studies; Drug Interactions; Epilepsy; Humans; Male; Valproic Acid | 1998 |
139 other study(ies) available for carbamazepine and caffeine
| Article | Year |
|---|---|
[3H]Batrachotoxinin A 20 alpha-benzoate binding to voltage-sensitive sodium channels: a rapid and quantitative assay for local anesthetic activity in a variety of drugs.
Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Anesthetics, Local; Animals; Batrachotoxins; Calcium Channel Blockers; Cyclic AMP; Guinea Pigs; Histamine H1 Antagonists; In Vitro Techniques; Ion Channels; Neurotoxins; Sodium; Tranquilizing Agents; Tritium | 1985 |
Computation of brain-blood partitioning of organic solutes via free energy calculations.
Topics: Animals; Blood-Brain Barrier; Brain; Cattle; Cells, Cultured; Endothelium, Vascular; Membrane Lipids; Microcirculation; Molecular Conformation; Molecular Structure; Monte Carlo Method; Permeability; Pharmaceutical Preparations; Software; Solubility; Thermodynamics | 1996 |
QSAR model for drug human oral bioavailability.
Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship | 2000 |
ElogPoct: a tool for lipophilicity determination in drug discovery.
Topics: 1-Octanol; Chromatography, High Pressure Liquid; Pharmaceutical Preparations; Solubility; Solvents | 2000 |
ElogD(oct): a tool for lipophilicity determination in drug discovery. 2. Basic and neutral compounds.
Topics: 1-Octanol; Chromatography, High Pressure Liquid; Pharmaceutical Preparations; Solubility; Water | 2001 |
Cheminformatic models to predict binding affinities to human serum albumin.
Topics: Adrenergic beta-Antagonists; Antidepressive Agents, Tricyclic; Chromatography, Affinity; Cyclooxygenase Inhibitors; Databases, Factual; Humans; Hydrophobic and Hydrophilic Interactions; Penicillins; Pharmaceutical Preparations; Protein Binding; Quantitative Structure-Activity Relationship; Reproducibility of Results; Serum Albumin; Steroids | 2001 |
Caco-2 permeability, P-glycoprotein transport ratios and brain penetration of heterocyclic drugs.
Topics: ATP Binding Cassette Transporter, Subfamily B, Member 1; Brain; Caco-2 Cells; Cell Membrane Permeability; Heterocyclic Compounds; Humans; Protein Transport | 2003 |
Chemical genetics reveals a complex functional ground state of neural stem cells.
Topics: Animals; Cell Survival; Cells, Cultured; Mice; Molecular Structure; Neoplasms; Neurons; Pharmaceutical Preparations; Sensitivity and Specificity; Stem Cells | 2007 |
Hologram QSAR model for the prediction of human oral bioavailability.
Topics: Administration, Oral; Biological Availability; Holography; Humans; Models, Biological; Models, Molecular; Molecular Structure; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship | 2007 |
Toward an optimal blood-brain barrier shuttle by synthesis and evaluation of peptide libraries.
Topics: Biological Transport; Blood-Brain Barrier; Cell Survival; Drug Carriers; Humans; Levodopa; Membranes, Artificial; Peptide Library; Peptides; Permeability; Phenylalanine; Solubility | 2008 |
Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1.
Topics: Cell Line; Computer Simulation; Drug Design; Gene Expression Profiling; Humans; Hydrogen Bonding; Liver; Molecular Weight; Organic Cation Transporter 1; Pharmaceutical Preparations; Predictive Value of Tests; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Structure-Activity Relationship | 2008 |
Relationship between brain tissue partitioning and microemulsion retention factors of CNS drugs.
Topics: Brain; Central Nervous System; Chromatography, Liquid; Emulsions; Mass Spectrometry | 2009 |
Determination of permeability and lipophilicity of pyrazolo-pyrimidine tyrosine kinase inhibitors and correlation with biological data.
Topics: Humans; Lipids; Membranes, Artificial; Permeability; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-abl; Pyrazoles; Pyrimidines | 2009 |
Prediction of volume of distribution values in human using immobilized artificial membrane partitioning coefficients, the fraction of compound ionized and plasma protein binding data.
Topics: Blood Proteins; Chemistry, Physical; Computer Simulation; Humans; Membranes, Artificial; Models, Biological; Pharmaceutical Preparations; Protein Binding; Tissue Distribution | 2009 |
Development of an in silico model for human skin permeation based on a Franz cell skin permeability assay.
Topics: 1-Methyl-3-isobutylxanthine; Cell Line; Cell Membrane Permeability; Humans; Models, Biological; Quantitative Structure-Activity Relationship; Skin Absorption | 2010 |
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
Development of a phospholipidosis database and predictive quantitative structure-activity relationship (QSAR) models.
Topics: | 2008 |
N-methyl phenylalanine-rich peptides as highly versatile blood-brain barrier shuttles.
Topics: Aminolevulinic Acid; Animals; Animals, Newborn; Astrocytes; Biological Transport; Blood Vessels; Blood-Brain Barrier; Brain; Cattle; Cell Membrane Permeability; Cells, Cultured; Chromatography, High Pressure Liquid; Coculture Techniques; Drug Carriers; Endothelial Cells; gamma-Aminobutyric Acid; Mass Spectrometry; Molecular Structure; Nipecotic Acids; Oligopeptides; Phenylalanine; Rats | 2010 |
How well can the Caco-2/Madin-Darby canine kidney models predict effective human jejunal permeability?
Topics: Animals; Disease Models, Animal; Dogs; Humans; Jejunal Diseases; Kidney Diseases; Models, Biological; Permeability; Porosity; Regression Analysis | 2010 |
Developing structure-activity relationships for the prediction of hepatotoxicity.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; Tetracyclines; Thiophenes | 2010 |
Predicting phospholipidosis using machine learning.
Topics: Animals; Artificial Intelligence; Databases, Factual; Drug Discovery; Humans; Lipidoses; Models, Biological; Phospholipids; Support Vector Machine | 2010 |
A predictive ligand-based Bayesian model for human drug-induced liver injury.
Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands | 2010 |
Brain tissue binding of drugs: evaluation and validation of solid supported porcine brain membrane vesicles (TRANSIL) as a novel high-throughput method.
Topics: Absorption; Albumins; Animals; Brain; Brain Chemistry; Cell Membrane; Chromatography, High Pressure Liquid; Drug Evaluation, Preclinical; In Vitro Techniques; Lipids; Male; Microdialysis; Pharmaceutical Preparations; Protein Binding; Rats; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Swine; Tissue Distribution | 2011 |
Predicting hERG activities of compounds from their 3D structures: development and evaluation of a global descriptors based QSAR model.
Topics: Computer Simulation; Ether-A-Go-Go Potassium Channels; Humans; Molecular Structure; Organic Chemicals; Quantitative Structure-Activity Relationship | 2011 |
QSAR-based permeability model for drug-like compounds.
Topics: Caco-2 Cells; Cell Membrane Permeability; Drug Discovery; Humans; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship | 2011 |
Combination of GSH trapping and time-dependent inhibition assays as a predictive method of drugs generating highly reactive metabolites.
Topics: Glutathione; Pharmacology; Sulfur Radioisotopes | 2011 |
Predicting phenolic acid absorption in Caco-2 cells: a theoretical permeability model and mechanistic study.
Topics: Artificial Intelligence; Caco-2 Cells; Cell Membrane Permeability; Cinnamates; Enterocytes; Humans; Hydrophobic and Hydrophilic Interactions; Intestinal Absorption; Kinetics; Models, Biological; Molecular Conformation; Osmolar Concentration; Phenols | 2012 |
Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions.
Topics: Atorvastatin; Biological Transport; Drug Interactions; Estradiol; Estrone; HEK293 Cells; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Least-Squares Analysis; Liver; Liver-Specific Organic Anion Transporter 1; Models, Molecular; Multivariate Analysis; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Protein Isoforms; Pyrroles; Solute Carrier Organic Anion Transporter Family Member 1B3; Structure-Activity Relationship; Transfection | 2012 |
Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds.
Topics: Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Decision Trees; Drug Evaluation, Preclinical; Drug-Related Side Effects and Adverse Reactions; Glutathione; Humans; Liver; Pharmaceutical Preparations; Protein Binding | 2012 |
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Humans; Quantitative Structure-Activity Relationship | 2012 |
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests | 2013 |
Chameleon-like behavior of indolylpiperidines in complex with cholinesterases targets: Potent butyrylcholinesterase inhibitors.
Topics: Acetylcholinesterase; Butyrylcholinesterase; Cholinesterase Inhibitors; Dose-Response Relationship, Drug; Humans; Indoles; Molecular Structure; Piperidines; Structure-Activity Relationship | 2018 |
Design of novel monoamine oxidase-B inhibitors based on piperine scaffold: Structure-activity-toxicity, drug-likeness and efflux transport studies.
Topics: Alkaloids; Benzodioxoles; Caco-2 Cells; Cell Differentiation; Cell Survival; Dose-Response Relationship, Drug; Drug Design; Humans; Ligands; Molecular Structure; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Neuroprotective Agents; Oxidative Stress; Piperidines; Polyunsaturated Alkamides; Structure-Activity Relationship; Tumor Cells, Cultured | 2020 |
A New Class of Dengue and West Nile Virus Protease Inhibitors with Submicromolar Activity in Reporter Gene DENV-2 Protease and Viral Replication Assays.
Topics: Animals; Chlorocebus aethiops; Dengue Virus; Dose-Response Relationship, Drug; Genes, Reporter; HeLa Cells; Humans; Protease Inhibitors; Vero Cells; Virus Replication; West Nile virus | 2020 |
Beyond Basicity: Discovery of Nonbasic DENV-2 Protease Inhibitors with Potent Activity in Cell Culture.
Topics: Animals; Benzamides; Cell Survival; Dengue Virus; Drug Stability; Genes, Reporter; HeLa Cells; Humans; Microsomes, Liver; Protease Inhibitors; Rats; Small Molecule Libraries; Structure-Activity Relationship; Viral Nonstructural Proteins; Virus Replication | 2021 |
Chemical ionization mass spectrometry for rapid assay of drugs in serum.
Topics: Anticonvulsants; Barbiturates; Caffeine; Carbamazepine; Electrochemistry; Mass Spectrometry; Nicotine; Phenytoin; Primidone; Temperature; Time Factors | 1976 |
Chronic carbamazepine down-regulates adenosine A2 receptors: studies with the putative selective adenosine antagonists PD115,199 and PD116,948.
Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Behavior, Animal; Brain Chemistry; Caffeine; Carbamazepine; Clonidine; Cyclic AMP; Down-Regulation; Male; Mice; Mice, Inbred C57BL; Motor Activity; Phenylisopropyladenosine; Purines; Receptors, Adrenergic; Sulfonamides; Theophylline; Xanthines | 1990 |
Determination of anticonvulsant drugs and methyl xanthine derivatives in serum by liquid chromatography with direct injection: column-switching method using a new internal-surface reversed-phase silica support as a precolumn.
Topics: Anticonvulsants; Caffeine; Carbamazepine; Chromatography, High Pressure Liquid; Humans; Indicators and Reagents; Phenobarbital; Phenytoin; Primidone; Silicon Dioxide; Spectrophotometry, Ultraviolet; Theobromine; Theophylline; Xanthines | 1990 |
[Plasma determination of 7 common drugs by high performance liquid chromatography].
Topics: Anticonvulsants; Bronchodilator Agents; Caffeine; Carbamazepine; Chromatography, High Pressure Liquid; Ethosuximide; Phenobarbital; Phenytoin; Theophylline; Valproic Acid | 1989 |
Effect of phenytoin, carbamazepine, and valproic acid on caffeine metabolism.
Topics: Adolescent; Adult; Aged; Antipyrine; Caffeine; Carbamazepine; Cytochrome P-450 Enzyme System; Enzyme Induction; Epilepsy; Female; Half-Life; Humans; Hydrocortisone; Male; Middle Aged; Phenytoin; Valproic Acid | 1989 |
The role of the purinergic system in the control of stereotypy: relationship to D-1/D-2 dopamine receptor activity.
Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Benzazepines; Caffeine; Carbamazepine; Dopamine Antagonists; Drug Interactions; Electroencephalography; Haloperidol; Male; Rabbits; Receptors, Dopamine; Receptors, Dopamine D1; Receptors, Dopamine D2; Receptors, Purinergic; Stereotyped Behavior | 1989 |
Inhibition of anticonvulsant action of carbamazepine by aminophylline and caffeine in rats.
Topics: Aminophylline; Animals; Caffeine; Carbamazepine; Dose-Response Relationship, Drug; Drug Interactions; Rats; Rats, Inbred Strains | 1989 |
Depersonalization disorder: effects of caffeine and response to pharmacotherapy.
Topics: Adult; Caffeine; Carbamazepine; Clonazepam; Depersonalization; Dose-Response Relationship, Drug; Fear; Female; Humans; Panic | 1989 |
Carbamazepine, but not caffeine, is highly selective for adenosine A1 binding sites.
Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Caffeine; Carbamazepine; Cerebellum; Corpus Striatum; In Vitro Techniques; Male; Rats; Rats, Inbred Strains; Receptors, Purinergic | 1989 |
Inhibitory effects of carbamazepine on clonidine-induced aggressive behavior in mice.
Topics: Adenosine; Aggression; Animals; Behavior, Animal; Caffeine; Carbamazepine; Clonidine; Haloperidol; Male; Mice; Prazosin; Receptors, Cell Surface; Yohimbine | 1988 |
Electrophysiological and neurochemical investigations on the action of carbamazepine on the rat hippocampus.
Topics: Anesthetics, Local; Animals; Caffeine; Carbamazepine; Depression, Chemical; Glutamates; Glutamic Acid; Hippocampus; Imipramine; In Vitro Techniques; Male; Rats; Rats, Inbred Strains; Receptors, Cell Surface; Receptors, Purinergic; Sodium; Synaptic Transmission; Tritium | 1985 |
Anticonvulsant activity of carbamazepine and N6-L-phenylisopropyladenosine in rabbits. Relationship to adenosine receptors in central nervous system.
Topics: Adenosine; Animals; Anticonvulsants; Caffeine; Carbamazepine; Central Nervous System; Drug Interactions; Electroencephalography; Male; Pentylenetetrazole; Phenylisopropyladenosine; Rabbits; Receptors, Purinergic; Seizures | 1988 |
Is the purinergic system involved in the control of pathological movements?
Topics: Animals; Caffeine; Carbamazepine; Electroencephalography; Haloperidol; Male; Purines; Rabbits; Stereotyped Behavior | 1987 |
Adenosine antagonists. Lack of effect on the inhibition of kindled seizures in rats by carbamazepine.
Topics: Adenosine; Animals; Caffeine; Carbamazepine; Kindling, Neurologic; Male; Rats; Rats, Inbred Strains; Seizures; Theophylline | 1985 |
Sphenopalatine gangionectomy for cluster headache.
Topics: Adult; Analgesics; Caffeine; Carbamazepine; Cortisone; Diazepam; Ergotamine; Female; Ganglia, Autonomic; Headache; Humans; Isoproterenol; Male; Methods; Methysergide; Middle Aged; Neuralgia; Palate; Phenytoin; Progesterone; Prognosis; Sphenoid Bone | 1970 |
Interaction of anticonvulsant drugs with adenosine receptors in the central nervous system.
Topics: Adenosine; Animals; Anticonvulsants; Brain; Caffeine; Carbamazepine; Cerebellum; Cerebral Cortex; Cyclic AMP; Phenobarbital; Phenytoin; Rats; Rats, Inbred Strains; Receptors, Cell Surface; Receptors, Purinergic; Theophylline | 1984 |
Calcium-antagonistic effects of carbamazepine in epilepsies and affective psychoses.
Topics: Animals; Caffeine; Calcium Channel Blockers; Carbamazepine; Epilepsy; Guinea Pigs; Hippocampus; In Vitro Techniques; Magnesium; Membrane Potentials; Mood Disorders; Neurons; Penicillins; Verapamil | 1993 |
Adenosine A1 receptors in human hippocampus: inhibition of [3H]8-cyclopentyl-1,3-dipropylxanthine binding by antagonist drugs.
Topics: Aged; Anticonvulsants; Autoradiography; Binding, Competitive; Caffeine; Carbamazepine; Female; Hippocampus; Humans; Male; Middle Aged; Oxcarbazepine; Purinergic Antagonists; Receptors, Purinergic; Xanthines | 1993 |
Chronic caffeine and the anticonvulsant potency of antiepileptic drugs against maximal electroshock.
Topics: Animals; Anticonvulsants; Caffeine; Carbamazepine; Dose-Response Relationship, Drug; Drug Interactions; Electroshock; Male; Mice; Mice, Inbred Strains; Seizures | 1996 |
Determination of the effects of caffeine and carbamazepine on striatal dopamine release by in vivo microdialysis.
Topics: Adenosine; Animals; Anticonvulsants; Caffeine; Carbamazepine; Central Nervous System Stimulants; Corpus Striatum; Dopamine; Dose-Response Relationship, Drug; Ligands; Male; Microdialysis; Rats; Rats, Wistar; Receptors, Purinergic P1 | 1997 |
Induction of CYP1A2 activity by carbamazepine in children using the caffeine breath test.
Topics: Adolescent; Analgesics, Non-Narcotic; Breath Tests; Caffeine; Carbamazepine; Carbon Dioxide; Central Nervous System Stimulants; Child; Cytochrome P-450 CYP1A2; Dose-Response Relationship, Drug; Drug Interactions; Epilepsy; Female; Humans; Male; Respiration | 1998 |
Stress-dependent antinociceptive effects of carbamazepine: a study in stressed and nonstressed rats.
Topics: Adenosine; Analgesics, Non-Narcotic; Analysis of Variance; Animals; Caffeine; Carbamazepine; Cerebral Ventricles; Dose-Response Relationship, Drug; Injections, Intraperitoneal; Injections, Intraventricular; Male; Naloxone; Pain; Physical Stimulation; Purinergic P1 Receptor Antagonists; Rats; Rats, Wistar; Restraint, Physical; Stress, Psychological; Time Factors | 1998 |
Pharmacological interactions between magnesium ion and adenosine on monoaminergic system in the central nervous system.
Topics: Adenosine; Animals; Biogenic Monoamines; Caffeine; Carbamazepine; Central Nervous System; Central Nervous System Stimulants; Dopamine; Dose-Response Relationship, Drug; Drug Interactions; Hippocampus; Magnesium; Male; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Rats; Rats, Wistar; Receptors, Purinergic P1; Serotonin; Theobromine; Theophylline; Visual Cortex | 1998 |
A reporter gene assay to assess the molecular mechanisms of xenobiotic-dependent induction of the human CYP3A4 gene in vitro.
Topics: Alkaline Phosphatase; beta-Naphthoflavone; Caffeine; Carbamazepine; Carcinoma, Hepatocellular; Clofibrate; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Dexamethasone; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Gene Expression Regulation; Genes, Reporter; Glucocorticoids; Hormone Antagonists; Humans; Isoniazid; Mifepristone; Mixed Function Oxygenases; Phenobarbital; Phenylbutazone; Phenytoin; Receptors, Glucocorticoid; Recombinant Proteins; Rifampin; Tumor Cells, Cultured; Xenobiotics | 1999 |
Stable isotopes labeling of drugs in pediatric clinical pharmacology.
Topics: Adolescent; Breath Tests; Caffeine; Carbamazepine; Child; Child, Preschool; Chromatography, High Pressure Liquid; Drug Therapy; Helicobacter Infections; Helicobacter pylori; Human Growth Hormone; Humans; Infant; Infant, Newborn; Isotope Labeling; Pancreas; Pediatrics; Theophylline | 1999 |
The anti-hyperalgesic effects of carbamazepine and oxcarbazepine are attenuated by treatment with adenosine receptor antagonists.
Topics: Analgesics, Non-Narcotic; Animals; Caffeine; Carbamazepine; Dose-Response Relationship, Drug; Drug Interactions; Hyperalgesia; Male; Oxcarbazepine; Pain Measurement; Purinergic P1 Receptor Antagonists; Rats; Rats, Wistar; Receptors, Purinergic P1 | 2004 |
Microcosm evaluation of the effects of an eight pharmaceutical mixture to the aquatic macrophytes Lemna gibba and Myriophyllum sibiricum.
Topics: Acetaminophen; Analysis of Variance; Atorvastatin; Biological Assay; Biomass; Caffeine; Carbamazepine; Complex Mixtures; Dose-Response Relationship, Drug; Heptanoic Acids; Heterocyclic Compounds; Levofloxacin; Magnoliopsida; Ofloxacin; Pharmaceutical Solutions; Pyrroles; Sertraline; Sulfamethoxazole; Toxicity Tests; Trimethoprim; Water Pollutants, Chemical | 2004 |
Effects of selected pharmaceuticals on riverine biofilm communities.
Topics: Bacteria; Biofilms; Bioreactors; Caffeine; Carbamazepine; Carbon Isotopes; Colony Count, Microbial; Drug Prescriptions; Ecosystem; Furosemide; Ibuprofen; In Situ Hybridization, Fluorescence; Microscopy, Confocal; Pharmaceutical Preparations; Rivers | 2005 |
Carbamazepine and its metabolites in wastewater and in biosolids in a municipal wastewater treatment plant.
Topics: Caffeine; Carbamazepine; Chromatography, Liquid; Environmental Monitoring; Ontario; Sewage; Spectrometry, Mass, Electrospray Ionization; Waste Disposal, Fluid; Water Pollutants, Chemical | 2005 |
Peripheral antinociception by carbamazepine in an inflammatory mechanical hyperalgesia model in the rat: a new target for carbamazepine?
Topics: Analgesics; Animals; Caffeine; Carbamazepine; Concanavalin A; Disease Models, Animal; Dose-Response Relationship, Drug; Hyperalgesia; Inflammation; Male; Pain; Rats; Rats, Wistar; Receptor, Adenosine A1; Time Factors; Touch; Xanthines | 2006 |
Effects of pharmaceutical products and municipal wastewaters on temperature-dependent mitochondrial electron transport activity in Elliptio complanata mussels.
Topics: Bivalvia; Caffeine; Carbamazepine; Cholestanol; Cotinine; Electron Transport; Fluoxetine; Ibuprofen; Lipid Peroxidation; Mitochondria; Novobiocin; Pharmaceutical Preparations; Sewage; Temperature; Trimethoprim; Xenobiotics | 2006 |
Peripheral anti-hyperalgesia by oxcarbazepine: involvement of adenosine A1 receptors.
Topics: Adenosine A1 Receptor Agonists; Adenosine A1 Receptor Antagonists; Animals; Anticonvulsants; Caffeine; Carbamazepine; Dose-Response Relationship, Drug; Drug Synergism; Functional Laterality; Hyperalgesia; Male; Oxcarbazepine; Peripheral Nervous System; Phosphoric Diester Hydrolases; Rats; Rats, Wistar; Receptor, Adenosine A1; Xanthines | 2006 |
Prediction of the clearance of eleven drugs and associated variability in neonates, infants and children.
Topics: Algorithms; Caffeine; Carbamazepine; Child; Computer Simulation; Humans; Infant; Infant, Newborn; Metabolic Clearance Rate; Midazolam; Models, Biological; Monte Carlo Method; Software | 2006 |
Novel generic UPLC/MS/MS method for high throughput analysis applied to permeability assessment in early Drug Discovery.
Topics: Ampicillin; Atenolol; Caffeine; Carbamazepine; Chromatography, High Pressure Liquid; Griseofulvin; Permeability; Pharmaceutical Preparations; Propranolol; Reproducibility of Results; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry | 2007 |
Miniaturized assay for solubility and residual solid screening (SORESOS) in early drug development.
Topics: Caffeine; Carbamazepine; Chromatography, Liquid; Crystallization; Drug Design; Hydrogen-Ion Concentration; Microchemistry; Pharmaceutical Preparations; Piroxicam; Powder Diffraction; Reproducibility of Results; Solubility; Solvents; Technology, Pharmaceutical; Temperature; X-Ray Diffraction | 2007 |
Pharmacodynamics of carbamazepine-mediated induction of CYP3A4, CYP1A2, and Pgp as assessed by probe substrates midazolam, caffeine, and digoxin.
Topics: Adult; ATP Binding Cassette Transporter, Subfamily B, Member 1; Caffeine; Carbamazepine; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP3A; Digoxin; Enzyme Induction; Humans; Male; Metabolic Clearance Rate; Midazolam; Middle Aged; Substrate Specificity | 2008 |
Factors impacting on pharmaceutical leaching following sewage application to land.
Topics: Adsorption; Caffeine; Carbamazepine; Models, Chemical; Pharmaceutical Preparations; Sewage; Soil; Therapeutic Irrigation; Volcanic Eruptions; Waste Disposal, Fluid | 2009 |
Microbial degradation of pharmaceuticals in estuarine and coastal seawater.
Topics: Absorption; Antipyrine; Bacteria; Biodegradation, Environmental; Caffeine; Carbamazepine; Cotinine; Diltiazem; Ecology; Endocrine Disruptors; Half-Life; New York; Nifedipine; Pharmaceutical Preparations; Seawater; Solubility; Sulfamethoxazole; Trimethoprim; Waste Disposal, Fluid; Water Microbiology; Water Pollutants, Chemical | 2009 |
Determination of hydrate transition temperature using transformation kinetics obtained by Raman spectroscopy.
Topics: Caffeine; Carbamazepine; Chemistry, Pharmaceutical; Crystallization; Kinetics; Molecular Structure; Molecular Weight; Phase Transition; Spectrum Analysis, Raman; Technology, Pharmaceutical; Temperature; Theophylline; Thermodynamics; Time Factors; Transition Temperature; Water | 2009 |
Manipulating hydrate formation during high shear wet granulation using polymeric excipients.
Topics: Caffeine; Calibration; Carbamazepine; Chemistry, Pharmaceutical; Crystallization; Drug Compounding; Excipients; Hypromellose Derivatives; Kinetics; Methylcellulose; Particle Size; Polymers; Powders; Software; Spectrum Analysis, Raman; Sulfaguanidine; Sulfathiazole; Sulfathiazoles | 2009 |
Degradation of fifteen emerging contaminants at microg L(-1) initial concentrations by mild solar photo-Fenton in MWTP effluents.
Topics: Aliivibrio fischeri; Anti-Infective Agents; Anti-Inflammatory Agents, Non-Steroidal; Caffeine; Carbamazepine; Cities; Cosmetics; Endocrine Disruptors; Environmental Restoration and Remediation; Herbicides; Hormones; Hydrogen Peroxide; Iron; Photolysis; Waste Disposal, Fluid; Water Pollutants, Chemical | 2010 |
Caffeine reverses antinociception by oxcarbazepine by inhibition of adenosine A1 receptors: insights using knockout mice.
Topics: Adenosine A1 Receptor Antagonists; Analgesics; Animals; Caffeine; Carbamazepine; Drug Antagonism; Female; Male; Mice; Mice, Knockout; Oxcarbazepine; Pain; Pain Measurement; Receptor, Adenosine A1 | 2010 |
Application of a novel solid-phase-extraction sampler and ultra-performance liquid chromatography quadrupole-time-of-flight mass spectrometry for determination of pharmaceutical residues in surface sea water.
Topics: Caffeine; Carbamazepine; Chromatography, Liquid; Drug Residues; Environmental Monitoring; Mass Spectrometry; Metoprolol; Oxazepam; Seawater; Solid Phase Extraction; Water Pollutants, Chemical | 2010 |
Occurrence and suitability of sucralose as an indicator compound of wastewater loading to surface waters in urbanized regions.
Topics: Caffeine; Carbamazepine; DEET; Gemfibrozil; Phosphines; Primidone; Sucrose; Sulfamethoxazole; Water Pollutants, Chemical | 2011 |
[Effect of migrepin on activity of trigeminal nucleus caudalis neurons].
Topics: Analgesics; Animals; Caffeine; Carbamazepine; Chlorobenzoates; Dose-Response Relationship, Drug; Drug Combinations; Dura Mater; Electric Stimulation; Injections, Intravenous; Male; Microelectrodes; Migraine Disorders; Neurons; Oscillometry; Potassium; Rats; Rats, Wistar; Trigeminal Caudal Nucleus | 2011 |
Reconnaissance of selected PPCP compounds in Costa Rican surface waters.
Topics: Anti-Bacterial Agents; Caffeine; Carbamazepine; Costa Rica; Environmental Monitoring; Fresh Water; Geography; Household Products; Limit of Detection; Mass Spectrometry; Pharmaceutical Preparations; Salinity; Surface Properties; Water Pollutants, Chemical; Water Pollution | 2011 |
Fecal coliforms, caffeine and carbamazepine in stormwater collection systems in a large urban area.
Topics: Caffeine; Carbamazepine; Chromatography, High Pressure Liquid; Enterobacteriaceae; Environmental Monitoring; Feces; Rain; Solid Phase Extraction; Tandem Mass Spectrometry; Urban Population; Water; Water Microbiology; Water Movements | 2012 |
Caffeine as an indicator for the quantification of untreated wastewater in karst systems.
Topics: Biodegradation, Environmental; Caffeine; Carbamazepine; Chromatography, High Pressure Liquid; Environmental Monitoring; Germany; Groundwater; Seasons; Sewage; Tandem Mass Spectrometry; Theobromine; Theophylline; Water Movements; Water Pollutants, Chemical | 2012 |
Assessment of groundwater pollution in Tokyo using PPCPs as sewage markers.
Topics: Antipyrine; Caffeine; Carbamazepine; Chromatography, Gas; Cosmetics; DEET; Drug Combinations; Environmental Monitoring; Escherichia coli; Groundwater; Mass Spectrometry; Salicylamides; Sewage; Terpenes; Tokyo; Toluidines; Water Movements; Water Pollutants, Chemical; Water Pollution | 2012 |
Fast investigations from biological matrices using CE--test of a blood-brain barrier model.
Topics: Acetaminophen; Adsorption; Animals; Blood-Brain Barrier; Caffeine; Carbamazepine; Cell Culture Techniques; Cell Line; Chromatography, Micellar Electrokinetic Capillary; Cimetidine; Humans; Indomethacin; Limit of Detection; Models, Biological; Propranolol; Rats; Reproducibility of Results; Tissue Distribution | 2012 |
Pharmaceutical removal in tropical subsurface flow constructed wetlands at varying hydraulic loading rates.
Topics: Caffeine; Carbamazepine; Clofibric Acid; Diclofenac; Ecosystem; Environmental Restoration and Remediation; Ketoprofen; Models, Chemical; Pharmaceutical Preparations; Rhizosphere; Tropical Climate; Waste Disposal, Fluid; Water Movements; Water Pollutants, Chemical; Wetlands | 2012 |
Caffeine in wastewater is a tracer for human fecal contamination.
Topics: Caffeine; Carbamazepine; Enterobacteriaceae; Environmental Monitoring; Feces; Humans; Quebec; Water; Water Microbiology; Water Pollution | 2012 |
Distribution and temporal evolution of pharmaceutically active compounds alongside sewage sludge treatment. Risk assessment of sludge application onto soils.
Topics: Anti-Bacterial Agents; Anti-Inflammatory Agents, Non-Steroidal; Caffeine; Carbamazepine; Clofibric Acid; Environmental Pollutants; Environmental Pollution; Estradiol; Gemfibrozil; Propranolol; Risk Assessment; Sewage; Soil; Spain; Time Factors | 2012 |
Batch versus continuous feeding strategies for pharmaceutical removal by subsurface flow constructed wetland.
Topics: Biodegradation, Environmental; Caffeine; Carbamazepine; Clofibric Acid; Diclofenac; Ibuprofen; Ketoprofen; Kinetics; Pharmaceutical Preparations; Waste Disposal, Fluid; Water Movements; Water Pollutants, Chemical; Wetlands | 2012 |
Immunoassays as high-throughput tools: monitoring spatial and temporal variations of carbamazepine, caffeine and cetirizine in surface and wastewaters.
Topics: Caffeine; Carbamazepine; Cetirizine; Chromatography, Liquid; Environmental Monitoring; Enzyme-Linked Immunosorbent Assay; Fresh Water; Germany; High-Throughput Screening Assays; Immunoassay; Wastewater; Water Pollutants, Chemical; Water Pollution, Chemical | 2012 |
Transition metal modified and partially calcined inorganic-organic pillared clays for the adsorption of salicylic acid, clofibric acid, carbamazepine, and caffeine from water.
Topics: Adsorption; Aluminum Silicates; Caffeine; Carbamazepine; Clay; Clofibric Acid; Salicylic Acid; Surface Properties; Transition Elements; Water | 2012 |
Detection of cocrystal formation based on binary phase diagrams using thermal analysis.
Topics: Caffeine; Calorimetry, Differential Scanning; Camphor; Carbamazepine; Crystallization; Heating; Indomethacin; Niacinamide; Pharmaceutical Preparations; Phase Transition; Piroxicam; Powder Diffraction; Salicylic Acid; Theophylline; X-Ray Diffraction | 2013 |
A panel of biological tests reveals developmental effects of pharmaceutical pollutants on late stage zebrafish embryos.
Topics: Animals; Behavior, Animal; Caffeine; Carbamazepine; Embryo, Nonmammalian; Gene Expression Regulation, Developmental; Heart Rate; Lithium Chloride; Motor Activity; Pentobarbital; Psychotropic Drugs; Theophylline; Toxicity Tests; Valproic Acid; Water Pollutants, Chemical; Zebrafish | 2012 |
Human pharmaceuticals in wastewaters from urbanized areas of Argentina.
Topics: Argentina; Atenolol; Caffeine; Carbamazepine; Chromatography, High Pressure Liquid; Cities; Diclofenac; Environmental Monitoring; Humans; Ibuprofen; Mass Spectrometry; Pharmaceutical Preparations; Wastewater; Water Pollutants, Chemical | 2013 |
Photocatalytic degradation of contaminants of concern with composite NF-TiO2 films under visible and solar light.
Topics: Atrazine; Caffeine; Carbamazepine; Catalysis; Microscopy, Electron, Scanning; Microscopy, Electron, Transmission; Nanoparticles; Nitrogen; Photolysis; Sunlight; Titanium; Wastewater; Water Pollutants, Chemical; X-Ray Diffraction | 2013 |
Uptake and depuration of pharmaceuticals in reclaimed water by mosquito fish (Gambusia holbrooki): a worst-case, multiple-exposure scenario.
Topics: Animals; Caffeine; Carbamazepine; Cyprinodontiformes; Diphenhydramine; Fresh Water; Ibuprofen; Pharmaceutical Preparations; Waste Disposal, Fluid; Wastewater; Water Pollutants, Chemical | 2013 |
Occurrence and fate of PPCPs and correlations with water quality parameters in urban riverine waters of the Pearl River Delta, South China.
Topics: Acetaminophen; Caffeine; Carbamazepine; Carbon; China; Ciprofloxacin; DEET; Environmental Monitoring; Erythromycin; Nitrates; Nitrites; Nitrogen; Pharmaceutical Preparations; Quaternary Ammonium Compounds; Rivers; Sulfamethoxazole; Trimethoprim; Water Pollutants, Chemical; Water Quality | 2013 |
Transcriptomic analysis in the developing zebrafish embryo after compound exposure: individual gene expression and pathway regulation.
Topics: Analysis of Variance; Animals; Biomarkers; Caffeine; Carbamazepine; Central Nervous System Stimulants; Embryo, Nonmammalian; Embryonic Development; Gene Expression Regulation, Developmental; Microarray Analysis; RNA; Signal Transduction; Teratogens; Transcriptome | 2013 |
Using lysosomal membrane stability of haemocytes in Ruditapes philippinarum as a biomarker of cellular stress to assess contamination by caffeine, ibuprofen, carbamazepine and novobiocin.
Topics: Animals; Biomarkers; Bivalvia; Caffeine; Carbamazepine; Hemocytes; Ibuprofen; Lysosomes; Neutral Red; Novobiocin; Wastewater; Water Pollutants, Chemical | 2013 |
Occurrence and suitability of pharmaceuticals and personal care products as molecular markers for raw wastewater contamination in surface water and groundwater.
Topics: Caffeine; Carbamazepine; Cosmetics; DEET; Environmental Monitoring; Fresh Water; Groundwater; Pharmaceutical Preparations; Sewage; Waste Disposal, Fluid; Wastewater; Water Pollutants, Chemical | 2014 |
Emerging organic contaminants in coastal waters: anthropogenic impact, environmental release and ecological risk.
Topics: Anti-Bacterial Agents; Anti-Inflammatory Agents, Non-Steroidal; Aquatic Organisms; Caffeine; Carbamazepine; Chromatography, Liquid; Environmental Monitoring; Gemfibrozil; Humans; Ketamine; N-Methyl-3,4-methylenedioxyamphetamine; Population Density; Pseudoephedrine; Risk; Rivers; Seawater; Solid Phase Extraction; Taiwan; Tandem Mass Spectrometry; Water Pollutants, Chemical | 2014 |
Single and multi-component adsorption of salicylic acid, clofibric acid, carbamazepine and caffeine from water onto transition metal modified and partially calcined inorganic-organic pillared clay fixed beds.
Topics: Adsorption; Bentonite; Caffeine; Carbamazepine; Clofibric Acid; Cobalt; Copper; Nickel; Pharmaceutical Preparations; Salicylic Acid; Water Pollutants, Chemical; Water Purification | 2015 |
Experimental and modeling study on removal of pharmaceutically active compounds in rotating biological contactors.
Topics: Adsorption; Biofilms; Bioreactors; Caffeine; Carbamazepine; Models, Theoretical; Pharmaceutical Preparations; Ranitidine; Sulfamethoxazole; Waste Disposal, Fluid; Water Pollutants, Chemical | 2014 |
Polymorph characterization of active pharmaceutical ingredients (APIs) using low-frequency Raman spectroscopy.
Topics: Caffeine; Carbamazepine; Crystallization; Crystallography; Ethanol; Filtration; Molecular Structure; Pharmaceutical Preparations; Powders; Pyrazoles; Pyridones; Solutions; Solvents; Spectroscopy, Fourier Transform Infrared; Spectrum Analysis, Raman; Theophylline; Vibration; Water | 2014 |
A dispersive liquid-liquid micellar microextraction for the determination of pharmaceutical compounds in wastewaters using ultra-high-performace liquid chromatography with DAD detection.
Topics: Caffeine; Carbamazepine; Chloroform; Chromatography, High Pressure Liquid; Ketoprofen; Liquid Phase Microextraction; Micelles; Naproxen; Ornidazole; Osmolar Concentration; Pharmaceutical Preparations; Polidocanol; Polyethylene Glycols; Solvents; Spain; Temperature; Wastewater; Water Pollutants, Chemical | 2015 |
The impact of different proportions of a treated effluent on the biotransformation of selected micro-contaminants in river water microcosms.
Topics: Acetaminophen; Biotransformation; Caffeine; Carbamazepine; Metoprolol; Pharmaceutical Preparations; Rivers; Sewage; Tetrazoles; Valine; Valsartan; Waste Disposal, Fluid; Water Pollutants, Chemical | 2014 |
In-situ synchrotron wide-angle X-ray diffraction as a rapid method for cocrystal/salt screening.
Topics: Caffeine; Calorimetry, Differential Scanning; Carbamazepine; Crystallization; Hot Temperature; Lamotrigine; Saccharin; Synchrotrons; Triazines; X-Ray Diffraction | 2015 |
Persistent and emerging micro-organic contaminants in Chalk groundwater of England and France.
Topics: Caffeine; Carbamazepine; England; Environmental Monitoring; Europe; France; Groundwater; Pesticides; Water Pollutants, Chemical | 2015 |
Puddles - A trigger for heterogeneous chemical influx into the unsaturated zone.
Topics: Caffeine; Carbamazepine; Carbon; Desvenlafaxine Succinate; Electric Conductivity; Groundwater; Israel; Limit of Detection; Nitrates; Sewage; Soil; Soil Pollutants; Sulfamethoxazole; Venlafaxine Hydrochloride; Water Pollutants; Water Pollutants, Chemical | 2015 |
Yes, caffeine, ibuprofen, carbamazepine, novobiocin and tamoxifen have an effect on Corbicula fluminea (Müller, 1774).
Topics: Animals; Biomarkers; Caffeine; Carbamazepine; Corbicula; DNA Damage; Environmental Monitoring; Glutathione Peroxidase; Glutathione Reductase; Glutathione Transferase; Ibuprofen; Lipid Peroxidation; Novobiocin; Oxidative Stress; Tamoxifen; Toxicity Tests; Water Pollutants, Chemical | 2015 |
General stress, detoxification pathways, neurotoxicity and genotoxicity evaluated in Ruditapes philippinarum exposed to human pharmaceuticals.
Topics: Acetylcholinesterase; Animals; Biomarkers; Bivalvia; Caffeine; Carbamazepine; Cytochrome P-450 CYP1A1; DNA Damage; Gastrointestinal Tract; Glutathione Peroxidase; Glutathione Reductase; Glutathione Transferase; Hemolymph; Ibuprofen; Inactivation, Metabolic; Lipid Peroxidation; Novobiocin; Oxidative Stress; Water Pollutants, Chemical | 2016 |
Adsorption of pharmaceuticals onto activated carbon fiber cloths - Modeling and extrapolation of adsorption isotherms at very low concentrations.
Topics: Acetaminophen; Adsorption; Caffeine; Carbamazepine; Carbon; Carbon Fiber; Charcoal; Diclofenac; Models, Theoretical; Reproducibility of Results; Water Purification | 2016 |
Long-term exposure to caffeine and carbamazepine: Impacts on the regenerative capacity of the polychaete Diopatra neapolitana.
Topics: Animals; Caffeine; Carbamazepine; Polychaeta; Regeneration; Toxicity Tests; Water Pollutants, Chemical | 2016 |
Chemical and biochemical characterization and in vivo safety evaluation of pharmaceuticals in drinking water.
Topics: Animals; Caffeine; Carbamazepine; Chromatography, High Pressure Liquid; Drinking Water; Environmental Exposure; Erythromycin; Kidney; Liver; Models, Theoretical; Pharmaceutical Preparations; Rats; Rats, Wistar; Tandem Mass Spectrometry; Water Purification | 2016 |
The role of sorption and biodegradation in the removal of acetaminophen, carbamazepine, caffeine, naproxen and sulfamethoxazole during soil contact: A kinetics study.
Topics: Acetaminophen; Adsorption; Biodegradation, Environmental; Caffeine; Carbamazepine; Kinetics; Models, Chemical; Naproxen; Soil; Soil Pollutants; Spain; Sulfamethoxazole; Waste Disposal, Fluid; Wastewater; Water Pollutants, Chemical | 2016 |
Hediste diversicolor as bioindicator of pharmaceutical pollution: Results from single and combined exposure to carbamazepine and caffeine.
Topics: Animals; Antioxidants; Biomarkers; Biotransformation; Caffeine; Carbamazepine; Catalase; Dose-Response Relationship, Drug; Energy Metabolism; Environmental Monitoring; Glutathione; Glutathione Transferase; Glycogen; Lipid Peroxidation; Oxidative Stress; Polychaeta; Superoxide Dismutase; Water Pollutants, Chemical | 2016 |
Source-specific sewage pollution detection in urban river waters using pharmaceuticals and personal care products as molecular indicators.
Topics: Caffeine; Carbamazepine; Environmental Monitoring; Humans; Japan; Pharmaceutical Preparations; Rivers; Sewage; Triclosan; Wastewater; Water Pollutants, Chemical; Water Quality | 2016 |
Poly vinyl acetate and ammonio methacrylate copolymer as unconventional polymer blends increase the mechanical robustness of HPMC matrix tablets.
Topics: Caffeine; Carbamazepine; Chemistry, Pharmaceutical; Drug Compounding; Drug Liberation; Excipients; Hypromellose Derivatives; Permeability; Polymers; Polyvinyls; Propranolol; Solubility; Tablets | 2017 |
Occurrence of Emerging Micropollutants in Water Systems in Gauteng, Mpumalanga, and North West Provinces, South Africa.
Topics: Benzhydryl Compounds; Benzopyrans; Caffeine; Carbamazepine; Drinking Water; Environmental Monitoring; Gas Chromatography-Mass Spectrometry; Nanoparticles; Phenols; South Africa; Tetrahydronaphthalenes; Water Pollutants, Chemical | 2017 |
Transport behavior of the pharmaceutical compounds carbamazepine, sulfamethoxazole, gemfibrozil, ibuprofen, and naproxen, and the lifestyle drug caffeine, in saturated laboratory columns.
Topics: Caffeine; Carbamazepine; Filtration; Gemfibrozil; Ibuprofen; Naproxen; Ontario; Silicon Dioxide; Sulfamethoxazole; Water Pollutants, Chemical | 2017 |
Investigating natural attenuation of pharmaceuticals through unsaturated column tests.
Topics: Acetaminophen; Caffeine; Carbamazepine; Kinetics; Naproxen; Nonlinear Dynamics; Pharmaceutical Preparations; Soil; Soil Pollutants; Sulfamethoxazole; Waste Disposal, Fluid; Wastewater; Water Pollutants, Chemical | 2017 |
Simultaneous extraction and concentration of water pollution tracers using ionic-liquid-based systems.
Topics: Caffeine; Carbamazepine; Chromatography, High Pressure Liquid; Humans; Ionic Liquids; Solid Phase Extraction; Spectrophotometry, Ultraviolet; Water Pollutants, Chemical | 2018 |
The effects of human drugs in Corbicula fluminea. Assessment of neurotoxicity, inflammation, gametogenic activity, and energy status.
Topics: Animals; Biomarkers; Caffeine; Carbamazepine; Corbicula; Energy Metabolism; Germ Cells; Humans; Ibuprofen; Inflammation; Neurotoxins; Novobiocin; Tamoxifen; Water Pollutants, Chemical | 2018 |
Supramolecular Metal-Phenolic Gels for the Crystallization of Active Pharmaceutical Ingredients.
Topics: Caffeine; Carbamazepine; Crystallization; Drug Liberation; Gels; Metals; Pharmaceutical Preparations; Piroxicam | 2018 |
Direct detection of the triphenylpyrylium-derived short-lived intermediates in the photocatalyzed degradation of acetaminophen, acetamiprid, caffeine and carbamazepine.
Topics: Acetaminophen; Benzene Derivatives; Caffeine; Carbamazepine; Light; Neonicotinoids; Oxidation-Reduction; Photolysis | 2018 |
Reliability of the Hansen solubility parameters as co-crystal formation prediction tool.
Topics: Caffeine; Carbamazepine; Chemistry, Pharmaceutical; Crystallization; Niacinamide; Piroxicam; Solubility; Theophylline | 2019 |
Wash-Free Multiplexed Mix-and-Read Suspension Array Fluorescence Immunoassay for Anthropogenic Markers in Wastewater.
Topics: Biomarkers; Caffeine; Carbamazepine; Chromatography, Liquid; Diclofenac; Environmental Monitoring; Fluorescence; Humans; Immunoassay; Limit of Detection; Suspensions; Tandem Mass Spectrometry; Wastewater; Water Pollutants, Chemical | 2019 |
Quantification of porogen effect on the drug release from single- and multi-layered ethylcellulose coated pellets containing single or combined drugs.
Topics: Caffeine; Carbamazepine; Cellulose; Chemistry, Pharmaceutical; Delayed-Action Preparations; Drug Carriers; Drug Liberation; Models, Theoretical; Porosity; Propranolol; Solubility; Water | 2020 |
Estimating the transport parameters of propyphenazone, caffeine and carbamazepine by means of a tracer experiment in a coarse-gravel unsaturated zone.
Topics: Antipyrine; Caffeine; Carbamazepine; Groundwater; Water Movements; Water Pollutants, Chemical | 2020 |
Modular, cost-effective, and portable capillary gradient liquid chromatography system for on-site analysis.
Topics: Caffeine; Carbamazepine; Chromatography, High Pressure Liquid; Cost-Benefit Analysis; Limit of Detection; Miniaturization; Point-of-Care Systems; Reproducibility of Results; Spectrophotometry, Ultraviolet; Sulfamethazine | 2020 |
Pharmaceutical Contaminants in Shallow Groundwater and Their Implication for Poor Sanitation Facilities in Low-Income Countries.
Topics: Bacteria; Caffeine; Carbamazepine; Chlorides; Environmental Monitoring; Escherichia coli; Groundwater; Nitrates; Pharmaceutical Preparations; Sanitation; Sulfamethoxazole; Wastewater; Water Pollutants, Chemical | 2022 |
Occurrence of pharmaceuticals and cocaine in the urban drainage channels located on the outskirts of the São Vicente Island (São Paulo, Brazil) and related ecological risk assessment.
Topics: Acetaminophen; Brazil; Caffeine; Carbamazepine; Cocaine; Environmental Monitoring; Humans; Losartan; Pharmaceutical Preparations; Risk Assessment; Water Pollutants, Chemical | 2022 |
First report on the occurrence of pharmaceuticals and cocaine in the coastal waters of Santa Catarina, Brazil, and its related ecological risk assessment.
Topics: Acetaminophen; Atenolol; Brazil; Caffeine; Carbamazepine; Chromatography, Liquid; Cocaine; Cosmetics; Diclofenac; Ecosystem; Environmental Monitoring; Humans; Losartan; Orphenadrine; Pharmaceutical Preparations; Risk Assessment; Sewage; Solid Waste; Tandem Mass Spectrometry; Water; Water Pollutants, Chemical | 2022 |
Identification of Potential Harmful Transformation Products of Selected Micropollutants in Outdoor and Indoor Swimming Pool Water.
Topics: Caffeine; Carbamazepine; Ozone; Swimming Pools; Water; Water Pollutants, Chemical; Water Purification | 2022 |
Distribution and ecological risks of pharmaceuticals and personal care products with different anthropogenic stresses in a coastal watershed of China.
Topics: Caffeine; Carbamazepine; China; Cosmetics; Ecosystem; Environmental Monitoring; Erythromycin; Pharmaceutical Preparations; Risk Assessment; Rivers; Sulfamethoxazole; Water; Water Pollutants, Chemical | 2022 |
Occurrence, ecological risk assessment and prioritization of pharmaceuticals and abuse drugs in estuarine waters along the São Paulo coast, Brazil.
Topics: Acetaminophen; Atenolol; Brazil; Caffeine; Carbamazepine; Chromatography, Liquid; Cocaine; Diclofenac; Ecosystem; Environmental Monitoring; Furosemide; Illicit Drugs; Losartan; Orphenadrine; Pharmaceutical Preparations; Risk Assessment; Rivers; Tandem Mass Spectrometry; Water Pollutants, Chemical | 2022 |
Mechanistic insights into UV photolysis of carbamazepine and caffeine: Active species, reaction sites, and toxicity evolution.
Topics: Caffeine; Carbamazepine; Ecosystem; Humans; Humic Substances; Hydroxyl Radical; Oxidation-Reduction; Oxygen Isotopes; Pharmaceutical Preparations; Photolysis; Singlet Oxygen; Ultraviolet Rays; Water; Water Pollutants, Chemical; Water Purification | 2022 |
A step forward on site-specific environmental risk assessment and insight into the main influencing factors of CECs removal from wastewater.
Topics: Caffeine; Carbamazepine; Ecosystem; Humans; Risk Assessment; Wastewater | 2023 |
On-farm Occurrence of Pharmaceuticals and Their Environmental Hazard: Case Study of a Tropical Dairy farm.
Topics: Acetaminophen; Animals; Caffeine; Carbamazepine; Environmental Monitoring; Farms; Ibuprofen; Ketoprofen; Pharmaceutical Preparations; Risperidone; Wastewater; Water; Water Pollutants, Chemical | 2023 |