carbamates has been researched along with urb 597 in 372 studies
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 0 (0.00) | 18.7374 |
1990's | 0 (0.00) | 18.2507 |
2000's | 114 (30.65) | 29.6817 |
2010's | 229 (61.56) | 24.3611 |
2020's | 29 (7.80) | 2.80 |
Authors | Studies |
---|---|
Bátkai, S; Bukoski, RD; Harvey-White, J; Kunos, G; Liu, J; Mackie, K; Offertáler, L; Osei-Hyiaman, D; Pacher, P; Radaeva, S; Rudd, MA | 1 |
Duranti, A; Fegley, D; Gaetani, S; Mor, M; Piomelli, D; Tarzia, G; Tontini, A | 1 |
Goldberg, SR; Makriyannis, A; Matthews, SA; Panlilio, LV; Solinas, M; Tanda, G | 1 |
Darmani, NA; Di Marzo, V; McClanahan, BA; Petrosino, S; Trinh, C; Valenti, M | 1 |
Bushell, KN; Clark, JD; Huang, N; Murphy, EA; Pan, N; Ramarao, MK; Shen, MW; Wang, Y; Williams, C | 1 |
Comelli, F; Costa, B; Fowler, CJ; Holt, S | 1 |
Lambert, DM; Okamoto, Y; Sun, YX; Tsuboi, K; Ueda, N; Zhao, LY | 1 |
Gessa, GL; Melis, M; Muntoni, AL; Perra, S; Pillolla, G; Pistis, M | 1 |
Bisogno, T; Cristino, L; de Novellis, V; Di Marzo, V; Guglielmotti, V; Maione, S; Palazzo, E; Petrosino, S; Rossi, F; Valenti, M | 1 |
Fegley, D; Gutierrez, T; Hohmann, AG; Piomelli, D; Suplita, RL | 1 |
Aslan, S; Greenwood, R; Jayamanne, A; Mitchell, VA; Piomelli, D; Vaughan, CW | 1 |
Bambico, FR; Bortolato, M; Campolongo, P; Cassano, T; Cuomo, V; Debonnel, G; Duranti, A; Gobbi, G; Goldberg, SR; Mangieri, R; Mor, M; Morgese, MG; Piomelli, D; Solinas, M; Tarzia, G; Tontini, A; Trezza, V | 1 |
Bolton, N; Connell, K; Hohmann, AG; Olsen, D; Piomelli, D | 1 |
Aguado, T; Cravatt, B; Galve-Roperh, I; Guzmán, M; Kokaia, Z; Lutz, B; Marsicano, G; Monory, K; Palazuelos, J; Stella, N | 1 |
Bermúdez-Silva, FJ; Hansson, AC; Heilig, M; Hyytiä, P; Kunos, G; Malinen, H; Rimondini, R; Rodriguez de Fonseca, F; Sanchez-Vera, I; Sommer, WH | 1 |
Jones, PG; Ramarao, MK; Rogers, KE; Uveges, A; Wang, Y; Xu, J | 1 |
Filip, M; McCreary, AC; Przegaliński, E; Zaniewska, M | 1 |
Goldberg, SR; Justinova, Z; Solinas, M; Tanda, G | 1 |
Brotchie, JM; Di Marzo, V; Lee, J | 1 |
Compton, TR; Dasse, O; Duranti, A; Monaghan, EP; Mor, M; Parrott, JA; Piomelli, D; Putman, D; Tarzia, G; Tontini, A | 1 |
Bandell, M; Cravatt, BF; McKinney, MK; Patapoutian, A; Saghatelian, A | 1 |
Alexander, JP; Cravatt, BF | 1 |
Duranti, A; Gatti, G; Kathuria, S; Lodola, A; Mor, M; Piersanti, G; Piomelli, D; Plazzi, PV; Rivara, S; Tarzia, G; Tontini, A | 1 |
Cichewicz, DL; Haller, VL; Welch, SP | 1 |
Clapper, JR; Duranti, A; Mor, M; Piomelli, D; Tarzia, G; Tontini, A | 1 |
Nomikos, GG; Panagis, G; Vlachou, S | 1 |
Fowler, CJ; Holt, S; Paylor, B | 1 |
Adriani, W; Canese, R; Laviola, G; Marco, EM; Podo, F; Viveros, MP | 1 |
Cross-Mellor, SK; Ossenkopp, KP; Parker, LA; Piomelli, D | 1 |
Barrett, DA; Chapman, V; Jhaveri, MD; Kendall, DA; Richardson, D | 1 |
Goldberg, SR; Justinova, Z; Makriyannis, A; Piomelli, D; Solinas, M; Tanda, G; Vadivel, SK; Wertheim, CE; Yasar, S | 1 |
Bhatia, P; Brioni, JD; Kolasa, T; Lannoye, GS; Patel, M; Richardson, P; Rogers, JC; Saraf, A; Stewart, A; Surowy, CS; Zhang, D; Zheng, GZ | 1 |
Ali, N; Chapman, V; Chimenti, M; de Lago, E; Fernandez-Ruiz, J; Kendall, DA; Millns, PJ; Ryland, E | 1 |
Ho, WS; Randall, MD | 1 |
Laitinen, JT; Lehtonen, M; Palomäki, VA; Savinainen, JR | 1 |
Hillard, CJ; Rademacher, DJ | 1 |
Lam, FF; Luk, PW; Ng, ES | 1 |
Ahn, K; Cravatt, BF; Lichtman, AH; Martin, BR; Naidu, PS; Varvel, SA | 1 |
Kreitzer, AC; Malenka, RC | 1 |
Chen, J; Faltynek, CR; Holzman, TF; Lake, MR; Moreland, RB; Neelands, T; Niforatos, W; Scott, VE; Walter, KA; Zhang, XF | 1 |
Alajakku, K; Fowler, CJ; Thors, L | 1 |
Drucker-Colin, R; Millán-Aldaco, D; Murillo-Rodríguez, E; Palomero-Rivero, M; Vázquez, E | 1 |
Trang, T | 1 |
Calignano, A; Compton, TR; Duranti, A; La Rana, G; Loverme, J; Mor, M; Parrott, J; Piomelli, D; Russo, R; Tarzia, G; Tontini, A | 1 |
Drysdale, AJ; Pertwee, RG; Platt, B; Ryan, D | 1 |
Arguello, O; Bortolato, M; Duranti, A; Fu, J; Kim, JH; Mangieri, RA; Mor, M; Piomelli, D; Tarzia, G; Tontini, A | 1 |
Luo, L; Tham, CS; Webb, M; Whitaker, J | 1 |
Agrò, AF; Bagetta, G; Bari, M; Cerulli, A; Corasaniti, MT; De Simone, C; Gasperi, V; Maccarrone, M; Morrone, LA; Nucci, C; Tartaglione, R; Terrinoni, A | 1 |
Castillo-Melendez, JA; Järvinen, T; Juvonen, RO; Kataja, AO; Koskinen, AM; Myllymäki, MJ; Nevalainen, T; Saario, SM | 1 |
Eriksson, J; Fowler, CJ; Thors, L | 1 |
Gorzalka, BB; Hill, MN; Morrish, AC | 1 |
Herradón, E; López-Miranda, V; Martín, MI | 1 |
Kaiser, N; Lutz, B; Monory, K; Moreira, FA | 1 |
Gorzalka, BB; Hill, MN; McLaughlin, RJ; Morrish, AC | 1 |
Artmann, A; Clausen, BH; Degn, M; Finsen, B; Hansen, HS; Hansen, SH; Lambertsen, KL; Lund, TM; Meldgaard, M; Petersen, G | 1 |
Gauthier, KM; Hammock, BD; Hillard, CJ; Ho, WS; Huang, H; Thompson, J; Wheelock, CE | 1 |
Cassano, T; Cuomo, V; Giuffrida, A; Morgese, MG | 1 |
Fratta, W; Goldberg, SR; Haller, J; Makriyannis, A; Medalie, J; Mikics, E; Piomelli, D; Scherma, M; Tanda, G; Vadivel, SK; Yasar, S | 1 |
Castiglioni, C; Di Marzo, V; Guidali, C; Maccarrone, M; Marras, E; Parolaro, D; Perletti, G; Petrosino, S; Realini, N; Rubino, T; Viganó, D | 1 |
Hungund, BL; Manzanares, J; Sanguino, E; Vinod, KY; Yalamanchili, R | 1 |
Ahn, K; Alexander, JP; Arendse, A; Cravatt, BF; Fitzgerald, LR; Johnson, DS; Liimatta, M; Lund, ET; Nomanbhoy, TK; Nugent, RA; Stevenson, T | 1 |
Limebeer, CL; Mechoulam, R; Parker, LA; Piomelli, D; Rock, EM | 1 |
Béquet, F; Desbazeille, M; Le Fur, G; Ludwiczak, P; Maftouh, M; Picard, C; Scatton, B; Uzabiaga, F | 1 |
Trezza, V; Vanderschuren, LJ | 2 |
Alizadeh, AM; Haghparast, A; Khani, A; Motamedi, F; Naderi, N; Rezaii, N; Saber-Tehrani, A | 1 |
Blankman, JL; Cravatt, BF; Simon, GM | 1 |
Finn, DP; Kelly, JP; O'Driscoll, M; Roche, M | 1 |
Bradshaw, HB; Burstein, S; Chen, JS; Cravatt, BF; Hu, SS; Hughes, HV; Jahnsen, JA; Masuda, K; McHugh, D; O'Dell, DK; Prieto, AL; Rimmerman, N; Thompson, EL; Vasko, MR; Vefring, E; Walker, JM | 1 |
Bilbao, A; Braconi, S; Cannella, N; Ciccocioppo, R; Cippitelli, A; Defonseca, FR; Duranti, A; Piomelli, D; Tontini, A | 1 |
Brand, S; Buckley, NE; Emmerdinger, D; Göke, B; Keenan, CM; Lutz, B; Massa, F; Patel, KD; Sharkey, KA; Sibaev, A; Storr, MA; Yüce, B; Zhang, H | 1 |
Alexander, SP; Barrett, DA; Bennett, AJ; Chapman, V; Garle, MJ; Jhaveri, MD; Kendall, DA; Patel, A; Richardson, D; Robinson, I; Sagar, DR; Sun, Y | 1 |
Njie, YF; Qiao, Z; Song, ZH; Wang, W; Xiao, Z | 1 |
Astarita, G; Eisenstein, SA; Hohmann, AG; Moise, AM; Piomelli, D | 1 |
Aziz Ahari, F; Motamedi, F; Naderi, N; Najarkolaei, AH; Shafaghi, B | 1 |
Cristino, L; Di Marzo, V; Drago, F; Leggio, GM; Micale, V; Petrosino, S; Tamburella, A | 1 |
Hasanein, P; Komaki, A; Mirazi, N; Shahidi, S | 1 |
Adamczyk, P; Filip, M; Gołda, A; McCreary, AC; Przegaliński, E | 1 |
Coomber, B; Mason, R; O'Donoghue, MF | 1 |
Fowler, CJ; Ghafouri, N | 1 |
Aguiar, DC; Guimarães, FS; Lisboa, SF; Resstel, LB | 1 |
Chapman, V; Kendall, DA; Sagar, DR | 1 |
Barnes, C; Fadda, P; Fattore, L; Fratta, W; Gamaleddin, I; Goldberg, SR; Haller, J; Justinová, Z; Le Foll, B; Medalie, J; Mikics, E; Panlilio, LV; Piomelli, D; Scherma, M; Stroik, J; Tanda, G; Yasar, S | 1 |
Haller, VL; Stevens, DL; Welch, SP | 1 |
Bortolato, M; Chefer, SI; Clapper, JR; Goldberg, SR; Justinova, Z; King, AR; Mangieri, RA; Mukhin, AG; Piomelli, D; Redhi, GH; Yasar, S | 1 |
Avraham, HK; Avraham, S; Koziel, H; Lu, TS; Makriyannis, A; Seng, S; Tachado, SD | 1 |
Butler, RK; Finn, DP; Gavin, AM; Lang, Y; Rea, K | 1 |
Billi, S; Farina, M; Franchi, AM; Gervasi, MG; Perez Martinez, S; Rapanelli, M; Ribeiro, ML | 1 |
Goldberg, SR; Luchicchi, A; Melis, M; Muntoni, AL; Pillolla, G; Pistis, M; Yasar, S | 1 |
Booker, L; Cravatt, BF; Lichtman, AH; Naidu, PS | 1 |
Adriani, W; Laviola, G; Marco, EM; Parolaro, D; Rubino, T; Viveros, MP | 1 |
Gardiner, SM; Ho, WS | 1 |
Bianchi, BR; Cavanaugh, EJ; Chen, J; Faltynek, CR; Kim, D; Kym, PR; Reilly, RM | 1 |
Boger, DL; Cravatt, BF; Lichtman, AH; Schlosburg, JE | 1 |
Kwiatkowska, M; Limebeer, CL; Litt, DL; Parker, LA; Piomelli, D; Rock, EM | 1 |
Barna, I; Barsvari, B; Goldberg, S; Gyimesi Pelczer, K; Haller, J; Panlilio, LV; Yasar, S | 1 |
Li, P; Longhurst, JC; Tjen-A-Looi, SC | 1 |
Kovacs, FE; Szabo, B; Urbanski, MJ | 1 |
Cadet, JL; Drago, F; Goldberg, SR; Mazzola, C; Medalie, J; Panlilio, LV; Scherma, M; Solinas, M; Tanda, G; Yasar, S | 1 |
Abdullah, RA; Carlson, BL; Cravatt, BF; Lichtman, AH; Long, JZ; Ramesh, D; Schlosburg, JE | 1 |
Benton, VM; Bradshaw, HB; Cravatt, BF; Hu, SS; Masuda, K; O'Dell, DK; Rimmerman, N; Stuart, JM; Walker, JM | 1 |
Käsnänen, H; Laitinen, JT; Leppänen, J; Minkkilä, A; Nevalainen, T; Poso, A; Saario, SM; Savinainen, JR; Xhaard, H | 1 |
Coen, KM; Forget, B; Le Foll, B | 1 |
Abdullah, RA; Boger, DL; Cravatt, BF; Kinsey, SG; Lichtman, AH; Long, JZ; O'Neal, ST; Poklis, JL | 1 |
Hasanein, P; Keshavarz, M; Parviz, M; Roohbakhsh, A | 1 |
Gontinou, C; Karaliota, S; Mavri-Vavayanni, M; Psarra, K; Siafaka-Kapadai, A | 1 |
Haghparast, A; Hosseini Najarkolaei, A; Motamedi, F; Naderi, N; Saber-Tehrani, A | 1 |
Eisenstein, SA; Hohmann, AG; Holmes, PV | 1 |
Advani, T; Cassano, T; Giuffrida, A; Hensler, JG; Seillier, A | 1 |
Hasanein, P; Keshavarz, S; Moghaddam, AH; Rezvani, ME; Roohbakhsh, A | 1 |
Cravatt, BF; Hillard, CJ; Liu, QS; Long, JZ; Pan, B; Sun, D; Wang, W | 1 |
Allen, CP; Lang, ST; Leri, F; Manwell, LA; Parker, LA; Satvat, E | 1 |
Floresco, SB; Gorzalka, BB; Hill, MN; Hillard, CJ; McLaughlin, RJ; Morrish, AC; Viau, V | 1 |
Fowler, CJ; Thors, L | 1 |
Anagnostopoulos, D; Gkini, E; Mavri-Vavayianni, M; Siafaka-Kapadai, A | 1 |
Adamczyk, P; Bienkowski, P; Filip, M; McCreary, AC; Mierzejewski, P; Przegalinski, E | 1 |
Galadari, S; Jaligam, V; Oz, M; Petroianu, G; Shippenberg, TS; Shuba, YM | 1 |
Bettoni, I; Comelli, F; Costa, B; Di Marzo, V; Giagnoni, G; Petrosino, S | 1 |
Burdet, B; De Laurentiis, A; Fernandez-Solari, J; Mohn, C; Rettori, V; Zorrilla Zubilete, MA | 1 |
Bernardi, G; Cantarella, C; Castelli, M; Cavasinni, F; Centonze, D; De Chiara, V; Mataluni, G; Musella, A; Rossi, S | 1 |
Baufreton, J; Manuel, I; Morera-Herreras, T; Rodriguez-Puertas, R; Ruiz-Ortega, JA; Taupignon, A; Ugedo, L | 1 |
Alger, BE; Kim, J | 1 |
Guindon, J; Hohmann, AG; Spradley, JM | 1 |
Bingham, B; Gorzalka, BB; Gray, JM; Hill, MN; Hillard, CJ; Lee, TT; McLaughlin, RJ; Shrestha, L; Viau, V | 1 |
Banke, TG; Chaplan, SR; Wickenden, AD | 1 |
Carta, S; Goldberg, SR; Lecca, S; Luchicchi, A; Muntoni, AL; Pillolla, G; Pistis, M; Yasar, S | 1 |
Benson, TE; Cravatt, BF; Kamtekar, S; Mileni, M; Stevens, RC; Wood, DC | 1 |
Bambico, FR; Cassano, T; Dominguez-Lopez, S; Gobbi, G; Katz, N; Piomelli, D; Walker, CD | 1 |
Alter, BJ; Burston, JJ; Cravatt, BF; Fowler, CJ; Gereau, RW; McKinney, MK; Pertwee, RG; Ross, RA; Thors, L; Wiley, JL | 1 |
De Bruyne, S; De Vos, F; Kapanda, CN; Labar, G; Lambert, DM; Muccioli, GG; Wyffels, L | 1 |
Limebeer, CL; McCallum, AL; Parker, LA | 1 |
Andrews, PL; Ho, WS; Percie du Sert, N; Rudd, JA | 1 |
De Chiaro, M; De Novellis, V; Gatta, L; Giordano, C; Guida, F; Krsiak, M; Luongo, L; Maione, S; Marabese, I; Migliozzi, AL; Palazzo, E; Siniscalco, D; Soukupová, M | 1 |
Anagnostopoulos, D; Evagorou, A; Farmaki, E; Siafaka-Kapadai, A | 1 |
Hacking, D; Kelly, RF; Lacerda, L; Lamont, KT; Lecour, S; Opie, LH; Somers, S; Thomas, P | 1 |
Bartolini, WP; Brotchie, JM; Fox, SH; Huot, P; Johnston, TH; Milne, GT; Pearson, JP; Sykes, KA; Wakefield, JD | 1 |
Casarotto, PC; Gomes, FV; Guimarães, FS; Resstel, LB | 1 |
Chambers, MG; Jassal, K; Johnson, MP; McDougall, JJ; Oskins, JL; Schuelert, N | 1 |
Bellini, G; Boccella, S; De Chiaro, M; de Novellis, V; Di Marzo, V; Gatta, L; Luongo, L; Maione, S; Marabese, I; Palazzo, E; Piscitelli, F; Rossi, F; Siniscalco, D; Vita, D | 1 |
Deadwyler, SA; Hampson, RE; Miller, F; Palchik, G | 1 |
Chapman, V; Lichtman, AH | 1 |
Giuffrida, A; Seillier, A | 2 |
McMahon, LR; Stewart, JL | 1 |
Arnold, JC; Hunt, GE; Long, LE; McGregor, IS; Sokolic, L | 1 |
Ahmad-Molaei, L; Aziz Ahari, F; Motamedi, F; Naderi, N | 1 |
Jain, NS; Manna, SS; Umathe, SN | 2 |
Berger, TW; Chan, RH; Deadwyler, SA; Goonawardena, AV; Hampson, RE; Marmarelis, VZ; Song, D; Sweatt, AJ | 1 |
Beltrame, JS; Burdet, J; Cella, M; Franchi, AM; Pardo, R; Ribeiro, ML; Sordelli, MS; Zotta, E | 1 |
Potschka, H; Soerensen, J; Wendt, H; Wotjak, CT | 1 |
Busquets-Garcia, A; de la Torre, R; Maldonado, R; Ozaita, A; Pastor, A; Puighermanal, E | 1 |
Cravatt, BF; Dudley, DT; Kinsey, SG; Lichtman, AH; Naidu, PS | 1 |
Alhamoruni, A; Larvin, M; O'Sullivan, SE; Wright, KL | 1 |
Hasanein, P; Shahidi, S | 1 |
Arias-Carrión, O; Drucker-Colín, R; Millán-Aldaco, D; Murillo-Rodríguez, E; Palomero-Rivero, M | 1 |
Butler, RK; Chapman, V; Doyle, KM; Finn, DP; Ford, GK; Hogan, M; Kelly, JP; Kendall, DA; Roche, M | 1 |
Ahmad-Molaei, L; Eslahkar, S; Mazar-Atabaki, A; Motiei-Langroudi, SM; Naderi, N; Ronaghi, A; Shirazi-zand, Z | 1 |
Burke, NN; Connor, TJ; Egan, LJ; Finn, DP; Ford, GK; Harhen, B; Kerr, DM; Roche, M | 1 |
Eriksen, GS; Gjerstad, J; Jacobsen, LM; Mahmood, A; Pedersen, LM | 1 |
Astarita, G; Caprioli, G; Ciccocioppo, R; Cippitelli, A; Duranti, A; Kallupi, M; Piomelli, D; Rodrìguez de Fonseca, F; Sagratini, G; Stopponi, S; Ubaldi, M | 1 |
Alves, FH; Corrêa, FM; Fedoce, AG; Ferreira-Junior, NC; Resstel, LB | 1 |
Baxter, P; Benfenati, F; Cerovic, M; Greco, B; Nazzaro, C; Parolaro, D; Pedarzani, P; Rubino, T; Tkatch, T; Tonini, R; Trusel, M | 1 |
Boczán, J; Czikora, Á; Daragó, A; Édes, I; Lizanecz, E; Papp, Z; Tóth, A | 1 |
Bambico, FR; Gobbi, G; Gorzalka, BB; Hill, MN; Hillard, CJ; McLaughlin, RJ; Stuhr, KL | 1 |
Centonze, D; Cutuli, D; De Chiara, V; Laricchiuta, D; Musella, A; Petrosini, L; Rossi, S | 1 |
Armirotti, A; Bandiera, T; Bertorelli, R; Colombano, G; Moreno-Sanz, G; Piomelli, D; Reggiani, A; Sasso, O; Scarpelli, R | 1 |
Bouzin, C; Feron, O; Gallez, B; Hamtiaux, L; Lambert, DM; Masquelier, J; Muccioli, GG | 1 |
Dunn, WR; Hopps, JJ; Randall, MD | 1 |
Dykstra, LA; Miller, LL; Picker, MJ; Schmidt, KT; Umberger, MD | 1 |
Blau, CW; Campbell, VA; Cowley, TR; Dempsey, CN; Finn, DP; Gowran, A; Lynch, MA; Murphy, N; Noonan, J; Olango, WM; Tanveer, R | 1 |
Harding-Rose, C; Khasabov, S; Khasabova, IA; Paz, J; Seybold, VS; Simone, DA | 1 |
Alexander, SP; Barrett, DA; Bennett, AJ; Burston, J; Chapman, V; Kendall, DA; Norris, LM; Okine, BN; Patel, A; Woodhams, S | 1 |
Cooper, TB; Hungund, BL; Psychoyos, D; Tejani-Butt, SM; Vinod, KY; Xie, S | 1 |
Baranowska-Kuczko, M; Kozłowska, H; MacLean, MR; Malinowska, B | 1 |
Currie, PJ; John, CS | 1 |
Araos, P; Calvo, EB; de Fonseca, FR; Galeano, P; Luque-Rojas, MJ; Santín, LJ; Suárez, J | 1 |
Abou-El-Ela, SH; El-Wakeil, AF; Zaitone, SA | 1 |
Canese, R; Ceci, C; Laviola, G; Macrì, S | 1 |
Bowie, AG; Campbell, VA; Gowran, A; Keating, SE; Noonan, J; Tanveer, R | 1 |
Bittles, V; Borazjani, A; Crow, JA; Potter, PM; Ross, MK | 1 |
Bosier, B; Lambert, DM; Muccioli, GG | 1 |
Bacigaluppi, M; Bari, M; Brambilla, E; Butti, E; Cambiaghi, M; Cebrian Silla, A; Centonze, D; Comi, G; D'Adamo, P; De Ceglia, R; De Chiara, V; Garcia-Verdugo, JM; Leocani, L; Maccarrone, M; Martino, G; Musella, A; Muzio, L; Quattrini, A; Rossi, S; Teneud, L | 1 |
Barker, E; Chester, JA; Cooper, BR; Davisson, VJ; Han, B; Kirchhoff, AM; Wright, R | 1 |
Campolongo, P; Cuomo, V; Damsteegt, R; Di Marzo, V; Manduca, A; Pasterkamp, RJ; Petrosino, S; Trezza, V; Van Kerkhof, LW; Vanderschuren, LJ; Zhou, Y | 1 |
Przewlocka, B; Starowicz, K | 1 |
Bradshaw, HB; Guindon, J; Hohmann, AG; Lai, Y; Takacs, SM | 1 |
Burger, F; Cravatt, B; Galan, K; Lenglet, S; Montecucco, F; Pelli, G; Soehnlein, O; Staub, C; Steffens, S; Thomas, A | 1 |
Avraham, HK; Li, H; Makriyannis, A; Seng, S; Vadivel, SK; Whitten, KM; Wood, JT | 1 |
de Oliveira, AC; Medeiros, DC; Moraes, MF; Moreira, FA; Rezende, GH; Vilela, LR | 1 |
Al-Banna, NA; Kelly, ME; Kianian, M; Lehmann, C | 1 |
Capoferri, L; Lodola, A; Mor, M; Mulholland, A; Piomelli, D; Rivara, S; Tarzia, G | 1 |
Banni, S; Cadeddu, F; Carta, G; Castelli, MP; De Montis, MG; Ennas, MG; Fadda, P; Fattore, L; Fratta, W; Frau, R; Lecca, S; Luchicchi, A; Madeddu, C; Melis, M; Pistis, M; Scheggi, S; Schilstrom, B | 1 |
Giuffrida, A; Martinez, AA; Seillier, A | 1 |
Cristino, L; De Petrocellis, L; Di Marzo, V; Korostynski, M; Makuch, W; Malek, N; Petrosino, S; Przewlocka, B; Slezak, M; Starowicz, K; Zychowska, M | 1 |
Bradshaw, HB; Cairns, EA; Di Polo, A; Kelly, ME; Slusar, JE; Szczesniak, AM | 1 |
Burlakova, N; Coicou, L; Harding-Rose, C; Holman, M; Khasabova, IA; Morse, T; Seybold, VS; Simone, DA | 1 |
Aguiar, DC; Gobira, PH; Moreira, FA | 1 |
Aliczki, M; Goldberg, SR; Haller, J; Panlilio, LV; Pelczer, KG | 1 |
Antunes-Rodrigues, J; Elias, LL; Ruginsk, SG; Uchoa, ET | 1 |
Centonze, D; Laricchiuta, D; Petrosini, L | 1 |
Aliczki, M; Balogh, Z; Haller, J; Kantor, S; Pelczer, KG; Spitzer, K | 1 |
Bindila, L; Fleischmann, BK; Lerner, R; Lutz, B; Matthey, M; Wenzel, D; Zimmer, A | 1 |
Cinar, R; Godlewski, G; Jourdan, T; Kunos, G; Lin, Y; Liu, J; Ntambi, JM; Xiong, K | 1 |
Cruz, JS; De Carvalho, CR; Pamplona, FA; Takahashi, RN | 1 |
Becker, A; Hoyer, FF; Kebschull, M; Khoury, M; Lerner, R; Lütjohann, D; Lutz, B; Nickenig, G; Schott, H; Slomka, H; Wojtalla, A; Zimmer, A | 1 |
Ceci, C; Laviola, G; Macrì, S; Marco, EM; Mela, V; Viveros, MP | 1 |
Anderson, WB; Gould, MJ; Mitchell, VA; Torres, RD; Vaughan, CW | 1 |
Abdullah, RA; Kwilasz, AJ; Lichtman, AH; Negus, SS; Poklis, JL | 1 |
Basavarajappa, BS; Nagre, NN; Subbanna, S; Xie, S | 1 |
Bystrowska, B; Filip, M; Gawliński, D; Pomierny, B; Smaga, I; Stankowicz, P | 1 |
Al Kury, LT; Ali, RM; Galadari, S; Howarth, FC; Oz, M; Rajesh, M; Shuba, YM; Thayyullathil, FT; Yang, KH | 1 |
Chavant, F; Duranti, A; Francheteau, M; Gennequin, B; Maccarrone, M; Makriyannis, A; Nader, J; Rapino, C; Solinas, M; Thiriet, N | 1 |
Andrews, MJ; Bradshaw, H; Czyzyk, T; Haskins, C; Jew, CP; Leishman, E; Lu, HC; Mackie, K; Morgan, D; Spencer, CM; Wu, CS | 1 |
Cravatt, BF; Germano, P; Hama, AT; Milne, GT; Pearson, JP; Sagen, J; Varghese, MS | 1 |
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Campolongo, P; Cuomo, V; Manduca, A; Palmery, M; Servadio, M; Trabace, L; Trezza, V; Vanderschuren, LJ | 1 |
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Hooker, JM; Liang, SH; Rotstein, BH; Shoup, TM; Vasdev, N; Wey, HY; Wilson, AA | 1 |
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Krustev, E; McDougall, JJ; Reid, A | 1 |
Aguiar, DC; Hott, SC; Moreira, FA; Resstel, LB; Viana, TG | 1 |
Fujinaga, M; Hatori, A; Kawamura, K; Kumata, K; Maeda, J; Nagai, Y; Ogawa, M; Shimoda, Y; Xie, L; Yamasaki, T; Yui, J; Zhang, MR | 1 |
de Ceballos, ML; Giusto, NM; Martín-Moreno, AM; Pascual, AC; Pasquaré, SJ | 1 |
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Khasabova, IA; Simone, DA; Uhelski, ML | 1 |
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Chauvet, C; Duranti, A; Lardeux, MV; Nicolas, C; Solinas, M; Thiriet, N | 1 |
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Campolongo, P; De Castro, V; Gray, JM; Hill, MN; Morena, M; Palmery, M; Roozendaal, B; Trezza, V | 1 |
Cox, CD; Gall, CM; Geschwind, DH; Karsten, CA; Lee, D; Peñagarikano, O; Piomelli, D; Wei, D | 1 |
Collier, TL; Fujinaga, M; Hatori, A; Kumata, K; Liang, SH; Mori, W; Ran, C; Rotstein, BH; Shimoda, Y; Vasdev, N; Wang, L; Wang, Q; Yamasaki, T; Yui, J; Zhang, MR; Zhang, Y | 1 |
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Fujinaga, M; Hatori, A; Ishii, H; Kumata, K; Kurihara, Y; Nengaki, N; Shimoda, Y; Xie, L; Yamasaki, T; Yui, J; Zhang, MR; Zhang, Y | 1 |
Bambico, FR; Duranti, A; Gobbi, G; Nobrega, JN | 1 |
Goldberg, SR; Justinova, Z; Makriyannis, A; Redhi, GH; Scherma, M; Schindler, CW; Vadivel, SK | 1 |
Aliczki, M; Baranyi, M; Barna, I; Goldberg, SR; Haller, J; Sperlagh, B; Till, I | 1 |
Alapafuja, SO; Bergman, J; Kangas, BD; Leonard, MZ; Makriyannis, A; Nikas, SP; Shukla, VG | 1 |
Forget, B; Gamaleddin, I; Goldberg, SR; Guranda, M; Le Foll, B | 1 |
Baranowska-Kuczko, M; Grzęda, E; Malinowska, B; Pędzińska-Betiuk, A; Toczek, M; Weresa, J | 1 |
Akirav, I; Zer-Aviv, TM | 1 |
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Cortesi, R; Drechsler, M; Esposito, E; Nastruzzi, C | 1 |
Baranowska-Kuczko, M; Harasim, E; Karpińska, O; Kasacka, I; Kloza, M; Kozłowska, H; Malinowska, B; Toczek, M | 1 |
Bielawska, K; Biernacki, M; Gęgotek, A; Skrzydlewska, E; Toczek, M; Łuczaj, W | 1 |
Giuffrida, A; Matricon, J; Seillier, A | 1 |
Freitas-Lima, LC; Meyrelles, SS; Nakamura-Palacios, EM; Pelição, R; Rodrigues, LC; Santos, MC; Vasquez, EC | 1 |
Aymerich, MS; Celorrio, M; Echeverry-Alzate, V; Fernández-Suárez, D; Franco, R; Hillard, CJ; López-Moreno, JA; Maldonado, R; Oyarzábal, J; Ramírez, MJ; Rojo-Bustamante, E | 1 |
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Alves-Silva, J; Batista, EM; Doria, JG; Ferguson, SS; Ferreira-Vieira, TH; Moreira, FA; Ribeiro, FM | 1 |
Campolongo, P; Gray, JM; Hill, MN; Leitl, KD; Morena, M; Vecchiarelli, HA | 1 |
Cador, M; Caillé, S; Rubino, T; Simonnet, A; Zamberletti, E | 1 |
Abassi, L; Jelinek, R; König, F; Lomazzo, E; Lutz, B | 1 |
Batista, LA; Haibara, AS; Moreira, FA; Schenberg, LC | 1 |
Hai, J; Lin, Q; Liu, K; Su, S; Wang, D; Wu, Y | 1 |
Colín-González, AL; Escamilla-Ramírez, A; Galván-Arzate, S; García, E; Palencia-Hernández, G; Santamaría, A; Sotelo, J; Túnez, I | 1 |
Castañeda-Achutiguí, F; Escalante-Castañeda, A; Flores-Soto, ME; Gonzalez-Castañeda, RE; Tejeda-Martínez, AR; Viveros-Paredes, JM | 1 |
Benítez-Valenzuela, J; Colín-González, AL; de Jesús Negrete-Ruíz, M; Martínez-Sánchez, JE; Maya-López, M; Parra-Cid, C; Rangel-López, E; Ruiz-Contreras, HA; Sánchez-Chapul, L; Santamaría, A; Villeda-Hernández, J | 1 |
Duan, T; Fang, Y; Gu, N; Han, J; Shen, Y; Wang, F; Wang, Y; Zhang, X; Zhu, J | 1 |
Barrett, DA; Couch, DG; Karwad, MA; Larvin, M; Lund, JN; O'Sullivan, SE; Sarmad, S; Theophilidou, E; Wright, KL | 1 |
Baranowska-Kuczko, M; Harasim-Symbor, E; Kasacka, I; Malinowska, B; Pędzińska-Betiuk, A; Toczek, M; Weresa, J | 1 |
Hai, J; Kasper, G; Lin, Q; Liu, KJ; Wang, DP | 1 |
Campolongo, P; Carducci, F; Cortesi, R; Drechsler, M; Esposito, E; Mariani, P; Melancia, F; Nastruzzi, C; Ratano, P; Servadio, M; Trezza, V | 1 |
Krustev, E; McDougall, JJ; Muley, MM; Philpott, HT; Reid, A | 1 |
Gupta, K; Simone, DA; Uhelski, ML | 1 |
Chabowski, A; Harasim-Symbor, E; Kasacka, I; Malinowska, B; Pędzińska-Betiuk, A; Polak, A; Weresa, J | 1 |
Aisenberg, N; Akirav, I; Sabban, EL; Serova, L | 1 |
Abush, H; Akirav, I; Mizrachi Zer-Aviv, T; Segev, A; Shoshan, N | 1 |
Giza, J; Gross, SS; Kreek, MJ; Lee, FS; Schwartz, BI; Zhou, Y | 1 |
DeVuono, MV; Hrelja, KM; MacPherson, DV; Parker, LA; Wills, KL | 1 |
Fu, HL; Lu, Y; Sun, HJ; Wang, HW; Wang, SR; Xu, WY; Yang, F; Yao, XY; Yuan, HB; Zhang, H | 1 |
Hai, J; Lin, Q; Su, SH; Wu, YF | 1 |
Genewsky, A; Heinz, DE; Wotjak, CT | 1 |
Benigno, A; Butini, S; Campiani, G; Colangeli, R; Di Giovanni, G; Pierucci, M | 1 |
Kitchigina, VF; Matveeva, N; Mikheeva, IB; Pavlik, LL; Shubina, L | 1 |
Borruto, AM; Cannella, N; Ciccocioppo, R; Domi, A; Fotio, Y; Natividad, L; Roberto, M; Stopponi, S | 1 |
Ambrożewicz, E; Bielawska, K; Biernacki, M; Gęgotek, A; Skrzydlewska, E; Toczek, M | 1 |
Berardi, A; Campolongo, P; Colucci, P; Hill, MN; Morena, M; Palmery, M; Trezza, V | 1 |
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Akirav, I; Burstein, O; Doron, R; Shoshan, N | 1 |
Akirav, I; Fidelman, S; Hillard, CJ; Lange, R; Mizrachi Zer-Aviv, T | 1 |
Chabowski, A; Harasim-Symbor, E; Kasacka, I; Lewandowska, A; Malinowska, B; Polak, A | 1 |
Carr, MR; Ferland, JN; Hoogeland, ME; Lee, AM; Pattij, T; Winstanley, CA | 1 |
Corcoran, L; Finn, DP; McGowan, F; Rea, K; Roche, M | 1 |
Gong, DY; Hai, KR; Jiang, HX; Ke, BW; Liu, J; Ma, G; Yang, Z; Zhou, C | 1 |
Chaves, YC; Crippa, JA; da Cunha, JM; de Morais, H; Genaro, K; Jesus, CHA; Waltrick, APF; Zanoveli, JM | 1 |
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Hai, J; Su, SH; Wang, DP; Wu, YF | 1 |
Abush, H; Akirav, I; Hillard, CJ; Korem, N; Lange, R; Mizrachi Zer-Aviv, T; Sauber, G; Segev, A | 1 |
Cuccurazzu, B; Grilli, M; Nazzaro, C; Parolaro, D; Prini, P; Rubino, T; Tonini, R; Trusel, M; Zamberletti, E | 1 |
Blanco, E; Fernández-Arjona, MDM; Grondona, JM; López-Ávalos, MD; Pavón, FJ; Rivera, P; Rodríguez de Fonseca, F; Serrano, A; Silva-Peña, D; Suárez, J; Vargas, A | 1 |
Biernacki, M; Jastrząb, A; Malinowska, B; Remiszewski, P; Skrzydlewska, E; Timoszuk, M; Toczek, M | 1 |
Ambrożewicz, E; Biernacki, M; Jarocka-Karpowicz, I; Skrzydlewska, E; Toczek, M; Łuczaj, W | 1 |
Ambrożewicz, E; Biernacki, M; Gęgotek, A; Skrzydlewska, E; Toczek, M | 1 |
Hohmann, AG; Iyer, V; Makriyannis, A; Saberi, SA; Slivicki, RA; Vemuri, VK | 1 |
Aliczki, M; Balogh, Z; Biro, L; Haller, J; Szente, L; Varga, ZK | 1 |
Fukumori, R; Nawata, Y; Yamaguchi, T; Yamamoto, T | 1 |
Dobrzyńska, I; Figaszewski, ZA; Skrzydlewska, E; Szachowicz-Petelska, B; Weresa, J | 1 |
Chabowski, A; Harasim-Symbor, E; Kasacka, I; Lewandowska, A; Malinowska, B; Pędzińska-Betiuk, A; Polak, A; Weresa, J | 1 |
Aguilera-Portillo, G; Colonnello, A; Galván-Arzate, S; Kotlar, I; Pedraza-Chaverri, J; Rangel-López, E; Santamaría, A; Serratos, IN; Túnez, I; Wajner, M | 1 |
Aguiar, DC; Bastos, JR; Coimbra, CC; Costa, RB; Hott, SC; Mansur, FS; Moreira, FA; Resstel, LB; Viana, TG | 1 |
Hohmann, AG; Mali, SS; Slivicki, RA; Xu, Z | 1 |
Correa, FM; Fassini, A; Guimarães, FS; Hartmann, A; Lisboa, SF; Resstel, LB; Scopinho, A | 1 |
Banaszkiewicz, I; Biala, G; Kruk-Slomka, M; Slomka, T | 1 |
Sackett, S; Tanaka, M; Yagyu, K; Zhang, Y | 1 |
Ebrahimi-Ghiri, M; Khakpai, F; Shahini, F; Zarrindast, MR | 1 |
Campolongo, P; Colucci, P; Hill, MN; Mancini, GF; Morena, M; Palmery, M; Puglisi-Allegra, S; Santori, A; Trezza, V | 1 |
Bellozi, PMQ; Campos, AC; de Oliveira, ACP; Lima, IVA; Nakamura-Palacios, EM; Pelição, R; Rodrigues, LCM; Saliba, SW; Santos, MC; Teixeira, AL; Vieira, ÉLM | 1 |
Chen, PS; Chu, MC; Lee, CW; Lin, HC; Lu, TY; Wu, HF | 1 |
Bisogno, T; Coccurello, R; Giacovazzo, G; Maccarrone, M; Oddi, S; Piscitelli, F; Verde, R | 1 |
Faron-Górecka, A; Filip, M; Gawlińska, K; Gawliński, D; Smaga, I; Zaniewska, M | 1 |
Akirav, I; Maymon, N; Mizrachi Zer-Aviv, T; Sabban, EL | 1 |
Demartini, C; Greco, R; Misto, A; Piomelli, D; Reggiani, A; Tassorelli, C; Tumelero, E; Zanaboni, AM | 1 |
Bortolanza, M; Crivelaro do Nascimento, G; Del Bel, EA; Ferrari, DP; Ferreira-Junior, NC; Guimaraes, FS | 1 |
Hai, J; Lin, Q; Su, SH; Wang, DP; Wu, YF | 1 |
Cancienne, HL; Edwards, S; Fucich, EA; Gilpin, NW; Middleton, JW; Molina, PE; Stielper, ZF | 1 |
Diwan, M; Giacobbe, P; Gidyk, DC; Gouveia, FV; Hamani, C; Lipsman, N; Nobrega, JN; Vimalanathan, A | 1 |
Dobrzyńska, I; Figaszewski, ZA; Pędzińska-Betiuk, A; Skrzydlewska, E; Szachowicz-Petelska, B | 1 |
Angelucci, CB; Ballone, A; Dainese, E; De Fabritiis, G; Dufrusine, B; Fezza, F; Maccarrone, M; Oddi, S; Sabatucci, A; Simonetti, M | 1 |
Abohalaka, R; Bozkurt, TE; Nemutlu, E; Onder, SC; Sahin-Erdemli, I | 1 |
Dronjak, S; Ferizovic, H; Jankovic, M; Spasojevic, N; Stefanovic, B | 3 |
Cui, J; Feng, L; James, TD; Li, L; Liu, T; Ma, X; Shao, B; Tian, X; Yao, D | 1 |
Baranowska-Kuczko, M; Biernacki, M; Niklińska, GN; Skrzydlewska, E | 1 |
Adelman, J; Akirav, I; Alteba, S; Ben David, G; Doron, R; Hillard, CJ; Mizrachi Zer-Aviv, T; Tenenhaus, A | 1 |
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Aschner, M; Chavira-Ramos, K; Colín-González, AL; Karasu, Ç; Orozco-Morales, M; Santamaría, A; Tinkov, AA | 1 |
Ebrahimi-Ghiri, M; Khakpai, F; Zarrindast, MR | 1 |
Arosio, B; Chiurchiù, V; Maccarrone, M; Mari, D; Oddi, S; Scipioni, L | 1 |
Baranowska-Kuczko, M; Biernacki, M; Harasim-Symbor, E; Kasacka, I; Kloza, M; Kozłowska, H; Malinowska, B | 1 |
Hai, J; Jin, KY; Kang, K; Lin, Q; Wang, DP; Zhao, P | 1 |
Gordon, RY; Khutsian, SS; Kitchigina, VF; Mikheeva, IB; Shubina, LV | 1 |
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Ebrahimi-Ghiri, M; Shahini, F; Zarrindast, MR | 1 |
Jerczynska, H; Stasiolek, M; Szemraj, J; Wysiadecki, G; Zubrzycka, M; Zubrzycki, M | 1 |
Hai, J; Kang, K; Lin, Q; Lv, QL; Sun, J; Wang, DP | 1 |
Huang, JY; Protti, DA; Yates, CF | 1 |
3 review(s) available for carbamates and urb 597
Article | Year |
---|---|
Pharmacological profile of the selective FAAH inhibitor KDS-4103 (URB597).
Topics: Amidohydrolases; Analgesics; Animals; Anxiety; Benzamides; Brain; Cannabinoids; Carbamates; Depression; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Inhibitors; Humans; Neurons; Pharmacokinetics | 2006 |
Inhibition of fatty acid amide hydrolase: a potential treatment for neuropathic pain.
Topics: Amidohydrolases; Animals; Benzamides; Carbamates; Mice; Neuralgia; Rats | 2007 |
Modulation of neuropathic-pain-related behaviour by the spinal endocannabinoid/endovanilloid system.
Topics: Amides; Amidohydrolases; Animals; Arachidonic Acid; Arachidonic Acids; Behavior; Benzamides; Carbamates; Endocannabinoids; Enzyme Inhibitors; Ethanolamines; Glycerides; Humans; Microglia; Neuralgia; Palmitic Acids; Peripheral Nerve Injuries; Polyunsaturated Alkamides; Receptor, Cannabinoid, CB1; Spinal Cord Injuries; TRPV Cation Channels | 2012 |
369 other study(ies) available for carbamates and urb 597
Article | Year |
---|---|
Endocannabinoids acting at cannabinoid-1 receptors regulate cardiovascular function in hypertension.
Topics: Amidohydrolases; Angiotensin II; Animals; Arachidonic Acids; Benzamides; Benzyl Compounds; Blood Pressure; Camphanes; Carbamates; Dronabinol; Endocannabinoids; Endothelium, Vascular; Hypertension; Male; Models, Cardiovascular; Myocardial Contraction; Myocardium; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rats; Rats, Inbred Dahl; Rats, Inbred SHR; Rats, Inbred WKY; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Rimonabant; Up-Regulation; Vascular Resistance; Vasodilation; Ventricular Function, Left | 2004 |
Characterization of the fatty acid amide hydrolase inhibitor cyclohexyl carbamic acid 3'-carbamoyl-biphenyl-3-yl ester (URB597): effects on anandamide and oleoylethanolamide deactivation.
Topics: Amidohydrolases; Animals; Arachidonic Acids; Benzamides; Body Temperature; Brain; Calcium Channel Blockers; Carbamates; Chromatography, High Pressure Liquid; Drug Synergism; Duodenum; Endocannabinoids; Enzyme Inhibitors; Feeding Behavior; Male; Mass Spectrometry; Mice; Mice, Inbred C57BL; Oleic Acids; Polyunsaturated Alkamides; PPAR alpha; Rats; Rats, Wistar | 2005 |
Cannabinoid agonists but not inhibitors of endogenous cannabinoid transport or metabolism enhance the reinforcing efficacy of heroin in rats.
Topics: Animals; Arachidonic Acids; Behavior, Animal; Benzamides; Benzoxazines; Cannabinoid Receptor Modulators; Cannabinoids; Carbamates; Conditioning, Operant; Dose-Response Relationship, Drug; Dronabinol; Drug Interactions; Heroin; Male; Morpholines; Naphthalenes; Narcotics; Rats; Rats, Sprague-Dawley; Reaction Time; Reinforcement Schedule; Reinforcement, Psychology; Self Administration; Time Factors | 2005 |
Cisplatin increases brain 2-arachidonoylglycerol (2-AG) and concomitantly reduces intestinal 2-AG and anandamide levels in the least shrew.
Topics: Analysis of Variance; Animals; Apomorphine; Arachidonic Acids; Benzamides; Benzyl Compounds; Brain; Carbamates; Cisplatin; Dopamine Agonists; Dose-Response Relationship, Drug; Drug Interactions; Endocannabinoids; Female; Glycerides; Intestinal Mucosa; Intestines; Male; Radiation-Sensitizing Agents; Serotonin; Shrews; Time Factors; Vomiting | 2005 |
A fluorescence-based assay for fatty acid amide hydrolase compatible with high-throughput screening.
Topics: Amidohydrolases; Animals; Arachidonic Acids; Benzamides; Biological Assay; Carbamates; CHO Cells; Coumarins; Cricetinae; Cricetulus; Dose-Response Relationship, Drug; Enzyme Inhibitors; Fluorescence; Fluorescent Dyes; Humans; Microsomes | 2005 |
Inhibitors of fatty acid amide hydrolase reduce carrageenan-induced hind paw inflammation in pentobarbital-treated mice: comparison with indomethacin and possible involvement of cannabinoid receptors.
Topics: Amidohydrolases; Animals; Anti-Inflammatory Agents, Non-Steroidal; Benzamides; Brain; Camphanes; Cannabinoid Receptor Antagonists; Carbamates; Carrageenan; Disease Models, Animal; Enzyme Inhibitors; Hindlimb; Indomethacin; Inflammation; Male; Mice; Mice, Inbred C57BL; Pentobarbital; Phenylmethylsulfonyl Fluoride; Pyrazoles; Spinal Cord | 2005 |
Involvement of N-acylethanolamine-hydrolyzing acid amidase in the degradation of anandamide and other N-acylethanolamines in macrophages.
Topics: Amides; Amidohydrolases; Animals; Arachidonic Acids; Benzamides; Brain; Carbamates; Cell Line; Cell Line, Tumor; Endocannabinoids; Enzyme Inhibitors; Ethanolamines; Gene Expression; Humans; Kidney; Liver; Lung; Macrophages; Macrophages, Peritoneal; Male; Mice; Mice, Inbred C57BL; Polyunsaturated Alkamides; Rats; Rats, Wistar; U937 Cells | 2005 |
Involvement of the endogenous cannabinoid system in the effects of alcohol in the mesolimbic reward circuit: electrophysiological evidence in vivo.
Topics: Animals; Benzamides; Cannabinoid Receptor Modulators; Carbamates; Dose-Response Relationship, Drug; Ethanol; Male; Nucleus Accumbens; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Reward; Rimonabant; Ventral Tegmental Area | 2005 |
Elevation of endocannabinoid levels in the ventrolateral periaqueductal grey through inhibition of fatty acid amide hydrolase affects descending nociceptive pathways via both cannabinoid receptor type 1 and transient receptor potential vanilloid type-1 re
Topics: Amidohydrolases; Analgesia; Animals; Benzamides; Benzoxazines; Cannabinoid Receptor Modulators; Carbamates; Endocannabinoids; Immunohistochemistry; Male; Medulla Oblongata; Morpholines; Naphthalenes; Pain; Periaqueductal Gray; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; TRPV Cation Channels | 2006 |
Endocannabinoids at the spinal level regulate, but do not mediate, nonopioid stress-induced analgesia.
Topics: Analgesia; Analysis of Variance; Animals; Arachidonic Acids; Behavior, Animal; Benzamides; Carbamates; Dose-Response Relationship, Drug; Drug Interactions; Endocannabinoids; Glycerides; Male; Mass Spectrometry; Pain Measurement; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rats; Rats, Sprague-Dawley; Reaction Time; Rimonabant; Serotonin; Spinal Cord; Stress, Psychological; Time Factors | 2006 |
Actions of the FAAH inhibitor URB597 in neuropathic and inflammatory chronic pain models.
Topics: Amidohydrolases; Animals; Benzamides; Carbamates; Chronic Disease; Disease Models, Animal; Enzyme Inhibitors; Hyperalgesia; Inflammation; Male; Motor Activity; Neuralgia; Pain; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; TRPV Cation Channels | 2006 |
Antidepressant-like activity and modulation of brain monoaminergic transmission by blockade of anandamide hydrolysis.
Topics: Animals; Antidepressive Agents; Arachidonic Acids; Behavior, Animal; Benzamides; Brain; Cannabinoid Receptor Agonists; Carbamates; Dronabinol; Endocannabinoids; Hydrolysis; Male; Mice; Mice, Inbred C57BL; Neurons; Norepinephrine; Polyunsaturated Alkamides; Rats; Receptors, Cannabinoid; Serotonin | 2005 |
Role of the basolateral nucleus of the amygdala in endocannabinoid-mediated stress-induced analgesia.
Topics: Amidohydrolases; Amygdala; Animals; Benzamides; Biphenyl Compounds; Cannabinoid Receptor Modulators; Carbamates; Endocannabinoids; Male; Microinjections; Monoacylglycerol Lipases; Pain; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Rimonabant; Stress, Psychological | 2006 |
The endocannabinoid system promotes astroglial differentiation by acting on neural progenitor cells.
Topics: Amidohydrolases; Animals; Apoptosis; Astrocytes; Benzamides; Benzoxazines; Cannabinoid Receptor Modulators; Cannabinoids; Carbamates; Cell Differentiation; Cells, Cultured; Endocannabinoids; Enzyme Inhibitors; Glial Fibrillary Acidic Protein; Hippocampus; Intermediate Filament Proteins; Mice; Mice, Knockout; Morpholines; Naphthalenes; Nerve Tissue Proteins; Nestin; Neurons; Rats; Receptor, Cannabinoid, CB1; Stem Cells | 2006 |
Genetic impairment of frontocortical endocannabinoid degradation and high alcohol preference.
Topics: Alcohol Drinking; Amidohydrolases; Analgesics; Animals; Behavior, Animal; Benzamides; Benzoxazines; Brain Chemistry; Cannabinoid Receptor Modulators; Carbamates; Central Nervous System Depressants; Dose-Response Relationship, Drug; Drug Interactions; Endocannabinoids; Ethanol; Gene Expression; Guanosine 5'-O-(3-Thiotriphosphate); In Situ Hybridization; Male; Morpholines; Naphthalenes; Piperidines; Prefrontal Cortex; Pyrazoles; Rats; Receptor, Cannabinoid, CB1; Reverse Transcriptase Polymerase Chain Reaction; Rimonabant; RNA, Messenger; Self Administration | 2007 |
A novel scintillation proximity assay for fatty acid amide hydrolase compatible with inhibitor screening.
Topics: Amidohydrolases; Animals; Arachidonic Acids; Benzamides; Binding Sites; Calcium Channel Blockers; Carbamates; CHO Cells; Cricetinae; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Endocannabinoids; Enzyme Inhibitors; Humans; Inhibitory Concentration 50; Ligands; Microsomes; Polyunsaturated Alkamides; Scintillation Counting; Wheat Germ Agglutinins | 2006 |
Evaluation of the role of nicotinic acetylcholine receptor subtypes and cannabinoid system in the discriminative stimulus effects of nicotine in rats.
Topics: Aconitine; Animals; Arachidonic Acids; Azetidines; Benzamides; Benzoxazines; Camphanes; Cannabinoid Receptor Antagonists; Carbamates; Cyclohexanols; Dihydro-beta-Erythroidine; Discrimination Learning; Dose-Response Relationship, Drug; Drug Synergism; Endocannabinoids; Male; Mecamylamine; Morpholines; Naphthalenes; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Polyunsaturated Alkamides; Pyrazoles; Pyridines; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Receptors, Cannabinoid; Receptors, Nicotinic | 2006 |
Anandamide administration alone and after inhibition of fatty acid amide hydrolase (FAAH) increases dopamine levels in the nucleus accumbens shell in rats.
Topics: Amidohydrolases; Animals; Arachidonic Acids; Benzamides; Calcium; Cannabinoids; Carbamates; Data Interpretation, Statistical; Dopamine; Endocannabinoids; Enzyme Inhibitors; Male; Microdialysis; Nucleus Accumbens; Polyunsaturated Alkamides; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Synaptic Transmission; Tetrodotoxin; TRPV Cation Channels | 2006 |
A role for vanilloid receptor 1 (TRPV1) and endocannabinnoid signalling in the regulation of spontaneous and L-DOPA induced locomotion in normal and reserpine-treated rats.
Topics: Adrenergic Uptake Inhibitors; Analysis of Variance; Animals; Arachidonic Acids; Behavior, Animal; Benzamides; Benzyl Compounds; Cannabinoid Receptor Modulators; Capsaicin; Carbamates; Dopamine Agents; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Inhibitors; Levodopa; Male; Motor Activity; Rats; Rats, Sprague-Dawley; Reserpine; Signal Transduction; TRPV Cation Channels | 2006 |
A FAAH-regulated class of N-acyl taurines that activates TRP ion channels.
Topics: Amidohydrolases; Animals; Benzamides; Carbamates; CHO Cells; Cricetinae; Enzyme Inhibitors; Mice; Mice, Knockout; Taurine; Tissue Distribution; TRPV Cation Channels | 2006 |
The putative endocannabinoid transport blocker LY2183240 is a potent inhibitor of FAAH and several other brain serine hydrolases.
Topics: Amidohydrolases; Animals; Antineoplastic Combined Chemotherapy Protocols; Benzamides; Brain; Cannabinoid Receptor Modulators; Carbamates; Cisplatin; Endocannabinoids; Gene Deletion; Heterocyclic Compounds, 1-Ring; Hydrolases; Ifosfamide; Male; Mice; Mice, Inbred C57BL; Mitomycin; Molecular Structure; Urea | 2006 |
Synthesis and structure-activity relationships of FAAH inhibitors: cyclohexylcarbamic acid biphenyl esters with chemical modulation at the proximal phenyl ring.
Topics: Amidohydrolases; Benzamides; Carbamates; Enzyme Inhibitors; Magnetic Resonance Spectroscopy; Models, Molecular; Quantitative Structure-Activity Relationship | 2006 |
Non-cannabinoid CB1, non-cannabinoid CB2 antinociceptive effects of several novel compounds in the PPQ stretch test in mice.
Topics: Acetaminophen; Amides; Analgesics; Animals; Arachidonic Acids; Benzamides; Benzoquinones; Camphanes; Capsaicin; Carbamates; Dose-Response Relationship, Drug; Dronabinol; Endocannabinoids; Ethanolamines; Hyperalgesia; Male; Mesencephalon; Mice; Mice, Inbred ICR; Narcotic Antagonists; Pain; Palmitic Acids; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Receptors, Opioid; Rimonabant; Spinal Cord; TRPV Cation Channels | 2006 |
The fatty-acid amide hydrolase inhibitor URB597 does not affect triacylglycerol hydrolysis in rat tissues.
Topics: Adipose Tissue, White; Amidohydrolases; Animals; Benzamides; Brain; Carbamates; Enzyme Inhibitors; Hydrolysis; Liver; Male; Myocardium; Rats; Rats, Wistar; Triglycerides; Triolein | 2006 |
Effects of endocannabinoid neurotransmission modulators on brain stimulation reward.
Topics: Amidohydrolases; Animals; Arachidonic Acids; Benzamides; Benzyl Compounds; Brain; Cannabinoid Receptor Modulators; Carbamates; Conditioning, Operant; Dose-Response Relationship, Drug; Electric Stimulation; Endocannabinoids; Injections, Intraperitoneal; Male; Medial Forebrain Bundle; Phenylmethylsulfonyl Fluoride; Piperidines; Polyunsaturated Alkamides; Protease Inhibitors; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Reinforcement Schedule; Reward; Rimonabant; Self Stimulation; Synaptic Transmission | 2006 |
The potency of the fatty acid amide hydrolase inhibitor URB597 is dependent upon the assay pH.
Topics: Amidohydrolases; Animals; Benzamides; Brain; Brain Neoplasms; Carbamates; Enzyme Inhibitors; Ethanolamine; Glioma; Hydrogen-Ion Concentration; Male; Rats; Rats, Sprague-Dawley; Rats, Wistar | 2006 |
Enhancement of endocannabinoid signalling during adolescence: Modulation of impulsivity and long-term consequences on metabolic brain parameters in early maternally deprived rats.
Topics: Amidohydrolases; Animals; Benzamides; Brain; Brain Chemistry; Cannabinoid Receptor Modulators; Carbamates; Conditioning, Operant; Endocannabinoids; Enzyme Inhibitors; Female; Hippocampus; Impulsive Behavior; Magnetic Resonance Spectroscopy; Maternal Deprivation; Motor Activity; Neostriatum; Nucleus Accumbens; Pregnancy; Rats; Rats, Wistar; Signal Transduction; Weight Gain | 2007 |
Effects of the FAAH inhibitor, URB597, and anandamide on lithium-induced taste reactivity responses: a measure of nausea in the rat.
Topics: Amidohydrolases; Animals; Arachidonic Acids; Association Learning; Avoidance Learning; Benzamides; Carbamates; Conditioning, Classical; Dose-Response Relationship, Drug; Endocannabinoids; Injections, Intraperitoneal; Lithium Chloride; Male; Nausea; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rats; Rats, Long-Evans; Receptor, Cannabinoid, CB1; Vomiting | 2007 |
Analgesic effects of fatty acid amide hydrolase inhibition in a rat model of neuropathic pain.
Topics: Amidohydrolases; Analgesics; Animals; Benzamides; Carbamates; Disease Models, Animal; Enzyme Inhibitors; Injections, Spinal; Male; Pain; Pain Measurement; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1 | 2006 |
The endogenous cannabinoid anandamide produces delta-9-tetrahydrocannabinol-like discriminative and neurochemical effects that are enhanced by inhibition of fatty acid amide hydrolase but not by inhibition of anandamide transport.
Topics: Amidohydrolases; Animals; Arachidonic Acids; Benzamides; Biological Transport, Active; Brain Chemistry; Carbamates; Discrimination Learning; Discrimination, Psychological; Dose-Response Relationship, Drug; Dronabinol; Endocannabinoids; Enzyme Inhibitors; Furans; Hallucinogens; Injections, Intraperitoneal; Injections, Intravenous; Male; Microdialysis; Nucleus Accumbens; Polyunsaturated Alkamides; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Reinforcement Schedule; TRPV Cation Channels | 2007 |
Fatty acid amide hydrolase inhibitors display broad selectivity and inhibit multiple carboxylesterases as off-targets.
Topics: Amidohydrolases; Animals; Antibodies; Benzamides; Brain; Carbamates; Carboxylesterase; Cell Line, Tumor; Enzyme Activation; Enzyme Inhibitors; Heart; Humans; Kidney; Liver; Proteome; Rats; Transfection | 2007 |
Effects of inhibition of fatty acid amide hydrolase vs. the anandamide membrane transporter on TRPV1-mediated calcium responses in adult DRG neurons; the role of CB receptors.
Topics: Amidohydrolases; Animals; Arachidonic Acids; Benzamides; Calcium; Capsaicin; Carbamates; Cells, Cultured; Dopamine; Drug Interactions; Endocannabinoids; Fura-2; Furans; Ganglia, Spinal; Male; Membrane Potentials; Membrane Transport Proteins; Neurons; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rats; Rats, Sprague-Dawley; TRPV Cation Channels | 2006 |
Endothelium-dependent metabolism by endocannabinoid hydrolases and cyclooxygenases limits vasorelaxation to anandamide and 2-arachidonoylglycerol.
Topics: Amidohydrolases; Animals; Arachidonic Acids; Benzamides; Cannabinoid Receptor Modulators; Carbamates; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Endocannabinoids; Endothelium, Vascular; Enzyme Inhibitors; Glycerides; Hydrolases; In Vitro Techniques; Lectins; Lectins, C-Type; Male; Membrane Proteins; Mesenteric Artery, Superior; Organophosphonates; Polyunsaturated Alkamides; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Wistar; Receptors, Cell Surface; Vasodilation; Vasodilator Agents | 2007 |
Visualization of 2-arachidonoylglycerol accumulation and cannabinoid CB1 receptor activity in rat brain cryosections by functional autoradiography.
Topics: Animals; Arachidonic Acids; Autoradiography; Benzamides; Binding, Competitive; Brain; Carbamates; Cryoultramicrotomy; Drug Interactions; Endocannabinoids; Enzyme Inhibitors; Glycerides; Guanosine 5'-O-(3-Thiotriphosphate); Male; Organophosphonates; Piperidines; Pyrazoles; Radiography; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Sulfones | 2007 |
Interactions between endocannabinoids and stress-induced decreased sensitivity to natural reward.
Topics: Analysis of Variance; Animals; Behavior, Animal; Benzamides; Body Weight; Cannabinoid Receptor Modulators; Carbamates; Cyclohexanes; Cyclohexanols; Dose-Response Relationship, Drug; Drinking Behavior; Drug Interactions; Endocannabinoids; Food Deprivation; Food Preferences; Male; Mice; Mice, Inbred ICR; Phenols; Piperidines; Pyrazoles; Restraint, Physical; Reward; Rimonabant; Stress, Psychological; Sucrose; Time Factors; Water Deprivation | 2007 |
Pharmacological characterization of receptor types mediating the dilator action of anandamide on blood vessels of the rat knee joint.
Topics: Amidohydrolases; Analysis of Variance; Animals; Arachidonic Acids; Benzamides; Blood Vessels; Cannabinoid Receptor Antagonists; Cannabinoid Receptor Modulators; Capsaicin; Carbamates; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Endocannabinoids; Flurbiprofen; Hindlimb; Indoles; Joints; Morpholines; Polyunsaturated Alkamides; Pyrazoles; Rats; Regional Blood Flow; TRPV Cation Channels; Vasodilation | 2007 |
Evaluation of fatty acid amide hydrolase inhibition in murine models of emotionality.
Topics: Amidohydrolases; Animals; Anxiety; Arachidonic Acids; Behavior, Animal; Benzamides; Cannabinoid Receptor Modulators; Carbamates; Depression; Disease Models, Animal; Dose-Response Relationship, Drug; Emotions; Endocannabinoids; Enzyme Inhibitors; Lighting; Maze Learning; Mice; Mice, Knockout; Polyunsaturated Alkamides; Pyridines; Signal Transduction | 2007 |
Endocannabinoid-mediated rescue of striatal LTD and motor deficits in Parkinson's disease models.
Topics: Animals; Benzamides; Benzoxazines; Cannabinoid Receptor Modulators; Carbamates; Disease Models, Animal; Dopamine; Dopamine D2 Receptor Antagonists; Endocannabinoids; Excitatory Postsynaptic Potentials; In Vitro Techniques; Long-Term Synaptic Depression; Mice; Mice, Transgenic; Morpholines; Naphthalenes; Neostriatum; Neuronal Plasticity; Oxidopamine; Parkinson Disease; Piperidines; Psychomotor Performance; Pyrazoles; Receptor, Cannabinoid, CB1; Receptors, Dopamine D2; Receptors, N-Methyl-D-Aspartate; Reserpine; Synapses | 2007 |
Activation of TRPA1 channels by the fatty acid amide hydrolase inhibitor 3'-carbamoylbiphenyl-3-yl cyclohexylcarbamate (URB597).
Topics: Amidohydrolases; Animals; Ankyrins; Benzamides; Calcium Channels; Carbamates; Cell Membrane; Ganglia, Spinal; Gene Expression; Humans; Ion Channel Gating; Male; Nerve Tissue Proteins; Neurons; Rats; Rats, Sprague-Dawley; Transfection; Transient Receptor Potential Channels; TRPA1 Cation Channel; TRPC Cation Channels; TRPM Cation Channels; TRPV Cation Channels | 2007 |
The 'specific' tyrosine kinase inhibitor genistein inhibits the enzymic hydrolysis of anandamide: implications for anandamide uptake.
Topics: Amidohydrolases; Animals; Arachidonic Acids; Benzamides; Brain; Carbamates; Cell Line, Tumor; Endocannabinoids; Genistein; Hydrolysis; Mice; Nystatin; Polyunsaturated Alkamides; Progesterone; Protein Kinase Inhibitors; Protein-Tyrosine Kinases; Rats | 2007 |
Effects of the fatty acid amide hydrolase inhibitor URB597 on the sleep-wake cycle, c-Fos expression and dopamine levels of the rat.
Topics: Amides; Amidohydrolases; Analgesics; Animals; Benzamides; Carbamates; Dopamine; Dose-Response Relationship, Drug; Endocannabinoids; Ethanolamines; Hippocampus; Injections, Intraventricular; Levodopa; Male; Microdialysis; Nucleus Accumbens; Oleic Acids; Palmitic Acids; Proto-Oncogene Proteins c-fos; Raphe Nuclei; Rats; Rats, Wistar; Sleep; Time Factors; Wakefulness | 2007 |
The fatty acid amide hydrolase inhibitor URB597 (cyclohexylcarbamic acid 3'-carbamoylbiphenyl-3-yl ester) reduces neuropathic pain after oral administration in mice.
Topics: Administration, Oral; Amidohydrolases; Analgesics; Animals; Benzamides; Capillary Permeability; Carbamates; Enzyme Inhibitors; Hyperalgesia; Male; Mice; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Spinal Cord | 2007 |
Interactions of cannabidiol with endocannabinoid signalling in hippocampal tissue.
Topics: Animals; Arachidonic Acids; Benzamides; Calcium; Cannabidiol; Cannabinoid Receptor Modulators; Carbamates; Cells, Cultured; Dronabinol; Endocannabinoids; Estrenes; Glutamic Acid; Glycerides; Hippocampus; Humans; Morpholines; Pertussis Toxin; Phosphodiesterase Inhibitors; Polyunsaturated Alkamides; Pyrazoles; Pyrrolidinones; Rats; Receptor, Cannabinoid, CB1; Signal Transduction | 2007 |
Antidepressant-like activity of the fatty acid amide hydrolase inhibitor URB597 in a rat model of chronic mild stress.
Topics: Amidohydrolases; Animals; Antidepressive Agents; Behavior, Animal; Benzamides; Body Weight; Brain; Cannabinoid Receptor Modulators; Carbamates; Chronic Disease; Disease Models, Animal; Dose-Response Relationship, Drug; Gene Expression Regulation; Imipramine; Lipid Metabolism; Male; Multivariate Analysis; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Stress, Psychological; Sucrose; Time Factors | 2007 |
Inhibition of microglial fatty acid amide hydrolase modulates LPS stimulated release of inflammatory mediators.
Topics: Amidohydrolases; Animals; Benzamides; Carbamates; Cells, Cultured; Cyclooxygenase 2; Dinoprostone; Inflammation Mediators; Lipopolysaccharides; Microglia; Nitric Oxide; Nitric Oxide Synthase Type II; Rats; Tumor Necrosis Factor-alpha | 2007 |
Involvement of the endocannabinoid system in retinal damage after high intraocular pressure-induced ischemia in rats.
Topics: Amidohydrolases; Animals; Arachidonic Acids; Benzamides; Cannabinoid Receptor Modulators; Capsaicin; Carbamates; Cell Count; Chromatography, High Pressure Liquid; Endocannabinoids; Enzyme Inhibitors; Enzyme-Linked Immunosorbent Assay; Hydrolysis; Intraocular Pressure; Male; Ocular Hypertension; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Reperfusion Injury; Retinal Diseases; Retinal Ganglion Cells; Retinal Vessels; Reverse Transcriptase Polymerase Chain Reaction; Rimonabant; RNA, Messenger; Thy-1 Antigens; TRPV Cation Channels | 2007 |
Design, synthesis, and in vitro evaluation of carbamate derivatives of 2-benzoxazolyl- and 2-benzothiazolyl-(3-hydroxyphenyl)-methanones as novel fatty acid amide hydrolase inhibitors.
Topics: Amidohydrolases; Animals; Benzamides; Benzothiazoles; Benzoxazoles; Brain; Carbamates; Drug Design; In Vitro Techniques; Male; Monoacylglycerol Lipases; Rats; Rats, Wistar; Structure-Activity Relationship | 2007 |
Inhibition of the cellular uptake of anandamide by genistein and its analogue daidzein in cells with different levels of fatty acid amide hydrolase-driven uptake.
Topics: 3T3-L1 Cells; Amidohydrolases; Animals; Arachidonic Acids; Benzamides; Biological Transport; Carbamates; Cell Line, Tumor; Dose-Response Relationship, Drug; Endocannabinoids; Genistein; Humans; Hydrogen-Ion Concentration; Hydrolysis; Isoflavones; Male; Mice; Molecular Structure; Polyunsaturated Alkamides; Protein Kinase Inhibitors; Rats; Tritium | 2007 |
Endocannabinoid modulation of male rat sexual behavior.
Topics: Amidohydrolases; Animals; Appetitive Behavior; Arachidonic Acids; Benzamides; Cannabinoid Receptor Modulators; Carbamates; Consummatory Behavior; Dose-Response Relationship, Drug; Ejaculation; Endocannabinoids; Enzyme Inhibitors; Male; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rats; Rats, Long-Evans; Receptor, Cannabinoid, CB1; Sexual Behavior, Animal | 2008 |
Characterization of the vasorelaxant mechanisms of the endocannabinoid anandamide in rat aorta.
Topics: Animals; Aorta, Abdominal; Apamin; Arachidonic Acids; Benzamides; Calcitonin Gene-Related Peptide; Camphanes; Cannabinoid Receptor Modulators; Capsaicin; Carbamates; Charybdotoxin; Dose-Response Relationship, Drug; Endocannabinoids; Endothelium, Vascular; In Vitro Techniques; Indomethacin; Isoindoles; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Peptide Fragments; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Rimonabant; Sulfonamides; Vasodilation | 2007 |
Reduced anxiety-like behaviour induced by genetic and pharmacological inhibition of the endocannabinoid-degrading enzyme fatty acid amide hydrolase (FAAH) is mediated by CB1 receptors.
Topics: Amidohydrolases; Analysis of Variance; Animals; Anxiety; Arachidonic Acids; Behavior, Animal; Benzamides; Carbamates; Disease Models, Animal; Endocannabinoids; Glycerides; Male; Maze Learning; Mice; Mice, Inbred C57BL; Mice, Knockout; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant | 2008 |
Local enhancement of cannabinoid CB1 receptor signalling in the dorsal hippocampus elicits an antidepressant-like effect.
Topics: Analysis of Variance; Animals; Antidepressive Agents; Behavior, Animal; Benzamides; Cannabinoid Receptor Modulators; Carbamates; Dentate Gyrus; Depression; Disease Models, Animal; Dronabinol; Hippocampus; Male; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Stress, Psychological; Swimming | 2007 |
Changes in brain levels of N-acylethanolamines and 2-arachidonoylglycerol in focal cerebral ischemia in mice.
Topics: Analysis of Variance; Animals; Arachidonic Acids; Benzamides; Brain; Brain Infarction; Brain Ischemia; Carbamates; Disease Models, Animal; Endocannabinoids; Enzyme Inhibitors; Ethanolamines; Glycerides; Male; Mice; RNA, Messenger; Time Factors | 2007 |
Inhibition of 2-arachidonoylglycerol catabolism modulates vasoconstriction of rat middle cerebral artery by the thromboxane mimetic, U-46619.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Amidohydrolases; Aniline Compounds; Animals; Arachidonic Acid; Arachidonic Acids; Benzamides; Benzoxazines; Carbamates; Dose-Response Relationship, Drug; Drug Synergism; Endocannabinoids; Enzyme Inhibitors; Glycerides; In Vitro Techniques; Male; Middle Cerebral Artery; Morpholines; Naphthalenes; Nimodipine; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Rimonabant; Thromboxanes; Vasoconstriction; Vasoconstrictor Agents | 2007 |
Anti-dyskinetic effects of cannabinoids in a rat model of Parkinson's disease: role of CB(1) and TRPV1 receptors.
Topics: Amidohydrolases; Animals; Antiparkinson Agents; Arachidonic Acids; Basal Ganglia; Benzamides; Benzoxazines; Cannabinoids; Capsaicin; Carbamates; Drug Therapy, Combination; Dyskinesia, Drug-Induced; Endocannabinoids; Levodopa; Male; Morpholines; Naphthalenes; Oxidopamine; Parkinson Disease, Secondary; Polyunsaturated Alkamides; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; TRPV Cation Channels | 2007 |
The endogenous cannabinoid anandamide has effects on motivation and anxiety that are revealed by fatty acid amide hydrolase (FAAH) inhibition.
Topics: Amidohydrolases; Analgesics; Analysis of Variance; Animals; Anxiety; Arachidonic Acids; Avoidance Learning; Behavior, Animal; Benzamides; Benzoxazines; Carbamates; Conditioning, Operant; Dose-Response Relationship, Drug; Endocannabinoids; Enzyme Inhibitors; Male; Morpholines; Motivation; Motor Activity; Naphthalenes; Polyunsaturated Alkamides; Rats; Rats, Sprague-Dawley; Time Factors | 2008 |
Role in anxiety behavior of the endocannabinoid system in the prefrontal cortex.
Topics: Animals; Anxiety; Arachidonic Acids; Benzamides; Cannabinoid Receptor Modulators; Carbamates; Dose-Response Relationship, Drug; Endocannabinoids; Male; Polyunsaturated Alkamides; Prefrontal Cortex; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1 | 2008 |
Manipulation of fatty acid amide hydrolase functional activity alters sensitivity and dependence to ethanol.
Topics: Alcohol Drinking; Amidohydrolases; Analgesics; Analgesics, Opioid; Animals; Behavior, Animal; Benzamides; Benzoxazines; Carbamates; Central Nervous System Depressants; Choice Behavior; Drug Interactions; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Ethanol; Guanosine 5'-O-(3-Thiotriphosphate); Hypothermia; Mice; Mice, Inbred C57BL; Mice, Knockout; Morpholines; Motor Activity; Naphthalenes; Protein Binding; Protein Precursors; Receptor, Cannabinoid, CB1 | 2008 |
Novel mechanistic class of fatty acid amide hydrolase inhibitors with remarkable selectivity.
Topics: Amidohydrolases; Anilides; Animals; Benzamides; Binding Sites; Carbamates; Enzyme Inhibitors; Humans; Inhibitory Concentration 50; Mice; Piperazines; Piperidines; Serine; Time Factors | 2007 |
The effect of cannabidiol and URB597 on conditioned gaping (a model of nausea) elicited by a lithium-paired context in the rat.
Topics: Amidohydrolases; Animals; Antiemetics; Antineoplastic Agents; Benzamides; Cannabidiol; Carbamates; Conditioning, Classical; Disease Models, Animal; Dose-Response Relationship, Drug; Lithium Chloride; Male; Nausea; Rats; Rats, Long-Evans; Rats, Sprague-Dawley; Vomiting, Anticipatory | 2008 |
CB1 receptor-mediated control of the release of endocannabinoids (as assessed by microdialysis coupled with LC/MS) in the rat hypothalamus.
Topics: Amidohydrolases; Animals; Arachidonic Acids; Benzamides; Benzoxazines; Cannabinoid Receptor Modulators; Cannabinoids; Carbamates; Chromatography, Liquid; Endocannabinoids; Extracellular Fluid; Glycerides; Hypothalamus; Male; Microdialysis; Morpholines; Naphthalenes; Piperidines; Polyunsaturated Alkamides; Potassium; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Rimonabant; Tandem Mass Spectrometry | 2007 |
Bidirectional cannabinoid modulation of social behavior in adolescent rats.
Topics: Analgesics, Opioid; Animals; Benzamides; Benzoxazines; Cannabinoids; Carbamates; Dopamine; Dopamine Antagonists; Exploratory Behavior; Flupenthixol; Male; Morphine; Morpholines; Motor Activity; Naloxone; Naphthalenes; Narcotic Antagonists; Piperidines; Play and Playthings; Pyrazoles; Rats; Rats, Wistar; Receptors, Dopamine; Reward; Rimonabant; Social Behavior | 2008 |
Interaction between cannabinoid compounds and diazepam on anxiety-like behaviour of mice.
Topics: Amidohydrolases; Animals; Anxiety; Arachidonic Acids; Behavior, Animal; Benzamides; Benzoxazines; Cannabinoids; Carbamates; Data Interpretation, Statistical; Diazepam; Dose-Response Relationship, Drug; Drug Combinations; Drug Interactions; Enzyme Inhibitors; GABA Modulators; Hypnotics and Sedatives; Male; Mice; Morpholines; Naphthalenes; Piperidines; Postural Balance; Pyrazoles; Receptor, Cannabinoid, CB1 | 2008 |
A comprehensive profile of brain enzymes that hydrolyze the endocannabinoid 2-arachidonoylglycerol.
Topics: Animals; Arachidonic Acids; Benzamides; Biotin; Brain; Carbamates; Catalysis; Chlorocebus aethiops; COS Cells; Endocannabinoids; Enzyme Inhibitors; Glycerides; Hydrolases; Lactones; Membrane Proteins; Mice; Mice, Inbred C57BL; Monoacylglycerol Lipases; Organophosphorus Compounds; Orlistat; Proteomics; Subcellular Fractions; Transfection | 2007 |
Augmentation of endogenous cannabinoid tone modulates lipopolysaccharide-induced alterations in circulating cytokine levels in rats.
Topics: Anilides; Animals; Arachidonic Acids; Benzamides; Cannabinoid Receptor Modulators; Carbamates; Cinnamates; Cytokines; Drug Synergism; Indoles; Interleukin-1beta; Interleukin-6; Lipopolysaccharides; Male; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Tumor Necrosis Factor-alpha | 2008 |
N-palmitoyl glycine, a novel endogenous lipid that acts as a modulator of calcium influx and nitric oxide production in sensory neurons.
Topics: Amidohydrolases; Animals; Antibodies; Benzamides; Brain Chemistry; Calcium; Carbamates; Cell Line; Crosses, Genetic; Dose-Response Relationship, Drug; Electrophysiology; Enzyme Inhibitors; Female; Ganglia, Spinal; Glycine; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Neurons, Afferent; Nitric Oxide; Nociceptors; Palmitic Acids; Pertussis Toxin; Rats; Rats, Sprague-Dawley; Receptors, Cannabinoid; Tissue Distribution; Up-Regulation | 2008 |
Cannabinoid and opioid modulation of social play behavior in adolescent rats: differential behavioral mechanisms.
Topics: Analgesics, Opioid; Analysis of Variance; Animals; Animals, Newborn; Behavior, Animal; Benzamides; Benzoxazines; Cannabinoids; Carbamates; Environment; Exploratory Behavior; Male; Morphine; Morpholines; Naphthalenes; Rats; Rats, Wistar; Recognition, Psychology; Social Behavior | 2008 |
Increase of brain endocannabinoid anandamide levels by FAAH inhibition and alcohol abuse behaviours in the rat.
Topics: Adrenergic alpha-Antagonists; Alcohol Drinking; Alcoholism; Amidohydrolases; Animals; Anxiety; Arachidonic Acids; Benzamides; Brain Chemistry; Carbamates; Conditioning, Operant; Cues; Electroshock; Endocannabinoids; Enzyme Inhibitors; Extinction, Psychological; Male; Polyunsaturated Alkamides; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Recurrence; Reinforcement Schedule; Self Administration; Stress, Psychological; Yohimbine | 2008 |
Targeting endocannabinoid degradation protects against experimental colitis in mice: involvement of CB1 and CB2 receptors.
Topics: Amidohydrolases; Animals; Arachidonic Acids; Benzamides; Cannabinoid Receptor Modulators; Carbamates; Colitis; Crohn Disease; Disease Models, Animal; Endocannabinoids; Humans; Mice; Mice, Inbred C57BL; Polymorphism, Genetic; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; RNA, Messenger; Trinitrobenzenesulfonic Acid | 2008 |
Inhibition of fatty acid amide hydrolase and cyclooxygenase-2 increases levels of endocannabinoid related molecules and produces analgesia via peroxisome proliferator-activated receptor-alpha in a model of inflammatory pain.
Topics: Amides; Amidohydrolases; Animals; Benzamides; Cannabinoid Receptor Modulators; Carbamates; Carrageenan; Cyclooxygenase 2; Disease Models, Animal; Dose-Response Relationship, Drug; Endocannabinoids; Enzyme Inhibitors; Ethanolamines; Guanosine 5'-O-(3-Thiotriphosphate); Hyperalgesia; Male; Pain Measurement; Palmitic Acids; PPAR alpha; Protein Binding; Rats; Rats, Sprague-Dawley; Sulfonamides; Time Factors; Weight-Bearing | 2008 |
N-arachidonylethanolamide-induced increase in aqueous humor outflow facility.
Topics: Amidohydrolases; Animals; Anterior Eye Segment; Aqueous Humor; Arachidonic Acids; Benzamides; Blotting, Western; Camphanes; Cannabinoid Receptor Antagonists; Cannabinoid Receptor Modulators; Carbamates; Chromatography, Thin Layer; Endocannabinoids; Organ Culture Techniques; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Receptors, Cannabinoid; Rimonabant; Swine; Trabecular Meshwork | 2008 |
An endocannabinoid signaling system modulates anxiety-like behavior in male Syrian hamsters.
Topics: Aggression; Amides; Amidohydrolases; Animals; Arousal; Autoradiography; Benzamides; Brain; Cannabinoid Receptor Modulators; Carbamates; Cricetinae; Dominance-Subordination; Endocannabinoids; Ethanolamines; Fear; Male; Maze Learning; Mesocricetus; Oleic Acids; Palmitic Acids; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant; Rotarod Performance Test; Signal Transduction; Social Environment | 2008 |
Evaluation of interactions between cannabinoid compounds and diazepam in electroshock-induced seizure model in mice.
Topics: Amidohydrolases; Animals; Anticonvulsants; Arachidonic Acids; Benzamides; Benzoxazines; Cannabinoid Receptor Modulators; Cannabinoids; Carbamates; Diazepam; Drug Interactions; Electroshock; Enzyme Inhibitors; Male; Mice; Morpholines; Naphthalenes; Postural Balance; Receptor, Cannabinoid, CB1; Seizures | 2008 |
Anxiolytic effects in mice of a dual blocker of fatty acid amide hydrolase and transient receptor potential vanilloid type-1 channels.
Topics: Amidohydrolases; Anilides; Animals; Anti-Anxiety Agents; Anxiety; Arachidonic Acids; Benzamides; Brain; Cannabinoid Receptor Modulators; Capsaicin; Carbamates; Cinnamates; Diazepam; Exploratory Behavior; Male; Mice; Mice, Inbred C57BL; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Serotonin; TRPV Cation Channels | 2009 |
Effects of URB597 as an inhibitor of fatty acid amide hydrolase on modulation of nociception in a rat model of cholestasis.
Topics: Amidohydrolases; Animals; Benzamides; Carbamates; Cholestasis; Disease Models, Animal; Injections, Intraperitoneal; Male; Pain; Pain Measurement; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2 | 2008 |
Activation of endocannabinoid transmission induces antidepressant-like effects in rats.
Topics: Animals; Antidepressive Agents; Arachidonic Acids; Benzamides; Cannabinoid Receptor Modulators; Carbamates; Depression; Dose-Response Relationship, Drug; Endocannabinoids; Immobilization; Male; Motor Activity; Rats; Rats, Wistar; Synaptic Transmission | 2008 |
Inhibition of endocannabinoid metabolism attenuates enhanced hippocampal neuronal activity induced by kainic acid.
Topics: Animals; Benzamides; Cannabinoid Receptor Modulators; Carbamates; Dose-Response Relationship, Drug; Endocannabinoids; Hippocampus; Kainic Acid; Male; Neural Inhibition; Neurons; Piperidines; Pyrazoles; Rats | 2008 |
Does the hydrolysis of 2-arachidonoylglycerol regulate its cellular uptake?
Topics: Amidohydrolases; Animals; Arachidonic Acids; Benzamides; Biphenyl Compounds; Cannabinoid Receptor Modulators; Carbamates; Cell Line, Tumor; Endocannabinoids; Glycerides; Humans; Hydrolysis; Polyunsaturated Alkamides | 2008 |
Activation of cannabinoid CB1 receptors in the dorsolateral periaqueductal gray induces anxiolytic effects in rats submitted to the Vogel conflict test.
Topics: Amidohydrolases; Animals; Anti-Anxiety Agents; Arachidonic Acids; Benzamides; Carbamates; Conflict, Psychological; Data Interpretation, Statistical; Drinking; Endocannabinoids; Enzyme Inhibitors; Male; Pain Measurement; Periaqueductal Gray; Polyunsaturated Alkamides; Rats; Rats, Wistar; Reaction Time; Receptor, Cannabinoid, CB1 | 2008 |
Inhibition of fatty acid amide hydrolase produces PPAR-alpha-mediated analgesia in a rat model of inflammatory pain.
Topics: Amidohydrolases; Analgesia; Animals; Benzamides; Carbamates; Carrageenan; Disease Models, Animal; Inflammation; Oxazoles; Pain; Piperidines; PPAR gamma; Pyrazoles; Rats; Receptor, Cannabinoid, CB1; Tyrosine | 2008 |
Inhibition of anandamide hydrolysis by cyclohexyl carbamic acid 3'-carbamoyl-3-yl ester (URB597) reverses abuse-related behavioral and neurochemical effects of nicotine in rats.
Topics: Amidohydrolases; Animals; Arachidonic Acids; Benzamides; Carbamates; Conditioning, Psychological; Dopamine; Endocannabinoids; Hydrolysis; Male; Motor Activity; Nicotine; Nucleus Accumbens; Polyunsaturated Alkamides; Rats; Rats, Long-Evans; Rats, Sprague-Dawley; Reward; Self Administration; Tobacco Use Disorder | 2008 |
Modulation of opioids via protection of anandamide degradation by fatty acid amide hydrolase.
Topics: Amidohydrolases; Analgesics, Opioid; Animals; Arachidonic Acids; Benzamides; Cannabinoid Receptor Modulators; Carbamates; Dose-Response Relationship, Drug; Drug Therapy, Combination; Endocannabinoids; Enzyme Inhibitors; Male; Mice; Mice, Inbred ICR; Mice, Knockout; Morphine; Pain; Polyunsaturated Alkamides; Receptor, Cannabinoid, CB1; Receptors, Opioid, kappa | 2008 |
Fatty acid amide hydrolase inhibition heightens anandamide signaling without producing reinforcing effects in primates.
Topics: Amidohydrolases; Analysis of Variance; Animals; Arachidonic Acids; Behavior, Animal; Benzamides; Brain; Cannabinoid Receptor Modulators; Carbamates; Chromatography, Liquid; Cocaine; Dose-Response Relationship, Drug; Dronabinol; Endocannabinoids; Male; Polyunsaturated Alkamides; Rats; Rats, Wistar; Reinforcement Schedule; Reinforcement, Psychology; Saimiri; Self Administration | 2008 |
Cannabinoids inhibit HIV-1 Gp120-mediated insults in brain microvascular endothelial cells.
Topics: AIDS Dementia Complex; Amidohydrolases; Anti-HIV Agents; Arachidonic Acids; Benzamides; Blood-Brain Barrier; Brain; Cannabinoid Receptor Modulators; Carbamates; Cell Line; Coculture Techniques; Endocannabinoids; Endothelium, Vascular; Glycerides; HIV Envelope Protein gp120; HIV-1; Humans; Microcirculation; Receptor, Cannabinoid, CB1 | 2008 |
Endocannabinoid-mediated enhancement of fear-conditioned analgesia in rats: opioid receptor dependency and molecular correlates.
Topics: Amidohydrolases; Amygdala; Analgesia; Animals; Arachidonic Acids; Avoidance Learning; Benzamides; Cannabinoid Receptor Modulators; Carbamates; Conditioning, Psychological; Endocannabinoids; Enzyme Inhibitors; Extracellular Signal-Regulated MAP Kinases; Fear; Male; Narcotic Antagonists; Neural Inhibition; Pain; Pain Measurement; Polyunsaturated Alkamides; Rats; Receptor, Cannabinoid, CB1; Receptors, Opioid; Signal Transduction | 2008 |
The endocannabinoid system in bull sperm and bovine oviductal epithelium: role of anandamide in sperm-oviduct interaction.
Topics: Amidohydrolases; Animals; Arachidonic Acids; Benzamides; Blotting, Western; Camphanes; Carbamates; Cattle; Endocannabinoids; Epithelium; Fallopian Tubes; Female; Immunohistochemistry; Male; Microscopy, Fluorescence; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Sperm Motility; Sperm-Ovum Interactions; Spermatozoa | 2009 |
Endogenous fatty acid ethanolamides suppress nicotine-induced activation of mesolimbic dopamine neurons through nuclear receptors.
Topics: Amides; Amidohydrolases; Animals; Appetite Depressants; Arachidonic Acids; Benzamides; Cannabinoid Receptor Antagonists; Carbamates; Dopamine; Endocannabinoids; Enzyme Activation; Enzyme Inhibitors; Ethanolamines; Injections, Intraventricular; Lipoxygenase Inhibitors; Male; Neurons; Nicotine; Oleic Acids; Organ Culture Techniques; Palmitic Acids; Patch-Clamp Techniques; Piperidines; PPAR alpha; Protein-Tyrosine Kinases; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptors, Cannabinoid; Rimonabant; Ventral Tegmental Area | 2008 |
Synergy between enzyme inhibitors of fatty acid amide hydrolase and cyclooxygenase in visceral nociception.
Topics: Acetic Acid; Amidohydrolases; Animals; Benzamides; Carbamates; Cyclooxygenase Inhibitors; Diclofenac; Dose-Response Relationship, Drug; Drug Synergism; Enzyme Inhibitors; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Naltrexone; Narcotic Antagonists; Nociceptors; Pain; Protective Agents; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Stomach Ulcer | 2009 |
Long-term consequences of URB597 administration during adolescence on cannabinoid CB1 receptor binding in brain areas.
Topics: Aging; Analysis of Variance; Animals; Arachidonic Acids; Autoradiography; Benzamides; Brain; Carbamates; Endocannabinoids; Male; Polyunsaturated Alkamides; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1 | 2009 |
Acute hypertension reveals depressor and vasodilator effects of cannabinoids in conscious rats.
Topics: Acute Disease; Amidohydrolases; Animals; Arachidonic Acids; Benzamides; Benzoxazines; Blood Pressure; Cannabinoids; Carbamates; Consciousness; Endocannabinoids; Hindlimb; Hypertension; Infusions, Intravenous; Injections, Intravenous; Male; Morpholines; Naphthalenes; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Renal Circulation; Splanchnic Circulation; Vascular Resistance; Vasodilation | 2009 |
Pore dilation occurs in TRPA1 but not in TRPM8 channels.
Topics: Aldehydes; Allyl Compounds; Anesthetics, Local; Animals; Benzamides; Benzoxazoles; Calcium; Calcium Channel Blockers; Calcium Channels; Calcium Signaling; Carbamates; Cells, Cultured; HeLa Cells; Humans; Ion Channel Gating; Lidocaine; Membrane Potentials; Movement; Nerve Tissue Proteins; Porins; Quinolinium Compounds; Rats; Thiocyanates; Transient Receptor Potential Channels; TRPA1 Cation Channel; TRPM Cation Channels | 2009 |
Endocannabinoid modulation of scratching response in an acute allergenic model: a new prospective neural therapeutic target for pruritus.
Topics: Amidohydrolases; Animals; Antipruritics; Behavior, Animal; Benzamides; Cannabinoid Receptor Modulators; Carbamates; Cell Degranulation; Dermatitis, Contact; Dose-Response Relationship, Drug; Dronabinol; Endocannabinoids; Enzyme Inhibitors; Genotype; Mast Cells; Mice; Mice, Inbred C57BL; Mice, Inbred ICR; p-Methoxy-N-methylphenethylamine; Pruritus; Pyridines; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Receptors, Cannabinoid | 2009 |
The FAAH inhibitor URB-597 interferes with cisplatin- and nicotine-induced vomiting in the Suncus murinus (house musk shrew).
Topics: Amidohydrolases; Animals; Arachidonic Acids; Benzamides; Carbamates; Cisplatin; Drug Interactions; Endocannabinoids; Female; Male; Nicotine; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant; Shrews; Vomiting | 2009 |
Interactions between environmental aversiveness and the anxiolytic effects of enhanced cannabinoid signaling by FAAH inhibition in rats.
Topics: Amidohydrolases; Animals; Anti-Anxiety Agents; Anxiety; Benzamides; Carbamates; Chlordiazepoxide; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme Inhibitors; Male; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Signal Transduction | 2009 |
Processing cardiovascular information in the vlPAG during electroacupuncture in rats: roles of endocannabinoids and GABA.
Topics: Animals; Benzamides; Cannabinoid Receptor Modulators; Carbamates; Drug Antagonism; Electroacupuncture; Endocannabinoids; gamma-Aminobutyric Acid; Hemodynamics; Male; Periaqueductal Gray; Piperidines; Pyrazoles; Pyridazines; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Reflex; Stomach; Sympathetic Nervous System | 2009 |
Depolarizing GABAergic synaptic input triggers endocannabinoid-mediated retrograde synaptic signaling.
Topics: Aniline Compounds; Animals; Animals, Newborn; Arachidonic Acids; Benzamides; Bicuculline; Biophysics; Calcium; Calcium Signaling; Cannabinoid Receptor Antagonists; Cannabinoid Receptor Modulators; Carbamates; Cerebellum; Electric Stimulation; Endocannabinoids; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Fluoresceins; GABA Agonists; GABA Antagonists; gamma-Aminobutyric Acid; Glycerides; In Vitro Techniques; Inhibitory Postsynaptic Potentials; Lactones; Mice; Muscimol; Orlistat; Patch-Clamp Techniques; Piperidines; Purkinje Cells; Pyrazoles; Quinoxalines; Rimonabant; Signal Transduction; Synapses; Valine | 2009 |
Fatty acid amide hydrolase (FAAH) inhibition enhances memory acquisition through activation of PPAR-alpha nuclear receptors.
Topics: Amidohydrolases; Animals; Benzamides; Brain; Carbamates; Enzyme Inhibitors; Learning; Male; Memory; PPAR alpha; Pyrimidines; Rats; Rats, Sprague-Dawley; Receptors, Cytoplasmic and Nuclear | 2009 |
Inhibitors of endocannabinoid-metabolizing enzymes reduce precipitated withdrawal responses in THC-dependent mice.
Topics: Amidohydrolases; Animals; Benzamides; Benzodioxoles; Cannabinoid Receptor Modulators; Carbamates; Dronabinol; Endocannabinoids; Enzyme Inhibitors; Hallucinogens; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Monoacylglycerol Lipases; Motor Activity; Piperidines; Postural Balance; Psychomotor Performance; Pyrazoles; Rimonabant; Substance Withdrawal Syndrome | 2009 |
The endocannabinoid anandamide is a precursor for the signaling lipid N-arachidonoyl glycine by two distinct pathways.
Topics: Amidohydrolases; Animals; Arachidonic Acids; Benzamides; Brain; Brain Chemistry; Carbamates; Cell Line, Tumor; Endocannabinoids; Glycine; Lipid Metabolism; Male; Metabolic Networks and Pathways; Mice; Mice, Knockout; Oxidation-Reduction; Polyunsaturated Alkamides; Rats; Recombinant Proteins | 2009 |
Screening of various hormone-sensitive lipase inhibitors as endocannabinoid-hydrolyzing enzyme inhibitors.
Topics: Amidohydrolases; Animals; Benzamides; Binding Sites; Carbamates; Computer Simulation; Crystallography, X-Ray; Drug Design; Enzyme Inhibitors; Hydrolysis; Mice; Monoacylglycerol Lipases; Oxadiazoles; Sterol Esterase; Structure-Activity Relationship | 2009 |
Inhibition of fatty acid amide hydrolase reduces reinstatement of nicotine seeking but not break point for nicotine self-administration--comparison with CB(1) receptor blockade.
Topics: Amidohydrolases; Animals; Behavior, Addictive; Benzamides; Carbamates; Enzyme Inhibitors; Male; Nicotine; Piperidines; Pyrazoles; Rats; Rats, Long-Evans; Receptor, Cannabinoid, CB1; Rimonabant; Self Administration; Smoking | 2009 |
Blockade of endocannabinoid-degrading enzymes attenuates neuropathic pain.
Topics: Amidohydrolases; Analgesics, Non-Narcotic; Animals; Arachidonic Acids; Benzamides; Benzodioxoles; Cannabinoid Receptor Modulators; Carbamates; Cold Temperature; Endocannabinoids; Enzyme Inhibitors; Glycerides; Hyperalgesia; Male; Mice; Mice, Inbred C57BL; Monoacylglycerol Lipases; Narcotic Antagonists; Pain; Pain Measurement; Peripheral Nervous System Diseases; Piperidines; Polyunsaturated Alkamides; Pyridines; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; TRPV Cation Channels | 2009 |
URB597, an inhibitor of fatty acid amide hydrolase, reduces hyperalgesia in diabetic rats.
Topics: Amidohydrolases; Animals; Benzamides; Blood Glucose; Body Weight; Cannabinoid Receptor Modulators; Carbamates; Diabetes Mellitus, Experimental; Dose-Response Relationship, Drug; Enzyme Inhibitors; Hyperalgesia; Injections, Intraperitoneal; Male; Pain Measurement; Pain Threshold; Rats; Rats, Wistar; Temperature | 2009 |
Anandamide increases the differentiation of rat adipocytes and causes PPARgamma and CB1 receptor upregulation.
Topics: Adipocytes; Adipose Tissue; Amidohydrolases; Animals; Arachidonic Acids; Benzamides; Blotting, Western; Carbamates; Cell Differentiation; Cyclooxygenase 2; Endocannabinoids; Enzyme Inhibitors; Flow Cytometry; Indomethacin; Male; Polyunsaturated Alkamides; PPAR gamma; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Reverse Transcriptase Polymerase Chain Reaction; Up-Regulation | 2009 |
Cannabinoids and their interactions with diazepam on modulation of serum corticosterone concentration in male mice.
Topics: Animals; Arachidonic Acids; Benzamides; Benzoxazines; Cannabinoid Receptor Antagonists; Cannabinoids; Carbamates; Corticosterone; Diazepam; Drug Interactions; Enzyme-Linked Immunosorbent Assay; Male; Mice; Morpholines; Naphthalenes | 2010 |
Endocannabinoid modulation of amphetamine sensitization is disrupted in a rodent model of lesion-induced dopamine dysregulation.
Topics: Amidohydrolases; Amphetamine; Animals; Benzamides; Cannabinoid Receptor Modulators; Carbamates; Central Nervous System Stimulants; Dopamine; Endocannabinoids; Enzyme Inhibitors; Exploratory Behavior; Male; Motor Activity; Olfactory Bulb; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1 | 2009 |
Inhibition of fatty-acid amide hydrolase and CB1 receptor antagonism differentially affect behavioural responses in normal and PCP-treated rats.
Topics: Amidohydrolases; Amphetamine; Animals; Autoradiography; Behavior, Animal; Benzamides; Cannabinoid Receptor Modulators; Carbamates; Central Nervous System Stimulants; Cyclohexanols; Drug Administration Schedule; Drug Interactions; Enzyme Inhibitors; Guanosine 5'-O-(3-Thiotriphosphate); Hallucinogens; Interpersonal Relations; Male; Memory, Short-Term; Motor Activity; Neuropsychological Tests; Phencyclidine; Piperidines; Protein Binding; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Statistics, Nonparametric; Sulfur Isotopes; Time Factors | 2010 |
Role of endocannabinoid system in the ventral hippocampus of rats in the modulation of anxiety-like behaviours.
Topics: Amidohydrolases; Animals; Anxiety; Baclofen; Behavior, Animal; Benzamides; Bicuculline; Cannabinoid Receptor Modulators; Carbamates; Dose-Response Relationship, Drug; Endocannabinoids; GABA Antagonists; Hippocampus; Male; Maze Learning; Piperidines; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1 | 2009 |
Blockade of 2-arachidonoylglycerol hydrolysis by selective monoacylglycerol lipase inhibitor 4-nitrophenyl 4-(dibenzo[d][1,3]dioxol-5-yl(hydroxy)methyl)piperidine-1-carboxylate (JZL184) Enhances retrograde endocannabinoid signaling.
Topics: Amidohydrolases; Animals; Arachidonic Acids; Benzamides; Benzodioxoles; Cannabinoid Receptor Modulators; Carbamates; Electrophysiology; Endocannabinoids; Enzyme Inhibitors; Glycerides; Hydrolysis; Lipase; Mice; Mice, Inbred C57BL; Mice, Knockout; Patch-Clamp Techniques; Piperidines; Purkinje Cells; Pyramidal Cells; Rats; Rats, Sprague-Dawley; Signal Transduction; Synapses | 2009 |
FAAH inhibitor, URB-597, promotes extinction and CB(1) antagonist, SR141716, inhibits extinction of conditioned aversion produced by naloxone-precipitated morphine withdrawal, but not extinction of conditioned preference produced by morphine in rats.
Topics: Amidohydrolases; Animals; Benzamides; Cannabinoid Receptor Modulators; Carbamates; Choice Behavior; Conditioning, Psychological; Dietary Sucrose; Extinction, Psychological; Female; Injections, Intraperitoneal; Injections, Subcutaneous; Male; Morphine; Morphine Dependence; Naloxone; Narcotic Antagonists; Narcotics; Piperidines; Pyrazoles; Rats; Rats, Long-Evans; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Reinforcement Schedule; Rimonabant; Species Specificity; Substance Withdrawal Syndrome | 2009 |
Suppression of amygdalar endocannabinoid signaling by stress contributes to activation of the hypothalamic-pituitary-adrenal axis.
Topics: Amidohydrolases; Amygdala; Animals; Arachidonic Acids; Benzamides; Cannabinoid Receptor Modulators; Carbamates; Corticosterone; Dronabinol; Drug Interactions; Endocannabinoids; Hypothalamo-Hypophyseal System; Male; Microinjections; Piperidines; Pituitary-Adrenal System; Polyunsaturated Alkamides; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Restraint, Physical; Signal Transduction; Stress, Psychological | 2009 |
Effect of nitric oxide donors on membrane tritium accumulation of endocannabinoids and related endogenous lipids.
Topics: Amides; Animals; Arachidonic Acids; Benzamides; Cannabinoid Receptor Modulators; Carbamates; Cell Line; Cell Membrane; Cyclic N-Oxides; Endocannabinoids; Ethanolamines; Free Radical Scavengers; Glycerides; Imidazoles; Lipid Metabolism; Mice; Nitric Oxide; Nitric Oxide Donors; Palmitic Acids; Polyunsaturated Alkamides; Rats; Signal Transduction; Tritium | 2009 |
Metabolism of 2-acylglycerol in rabbit and human platelets. Involvement of monoacylglycerol lipase and fatty acid amide hydrolase.
Topics: Amidohydrolases; Animals; Arachidonic Acids; Benzamides; Blood Platelets; Carbamates; Endocannabinoids; Enzyme Inhibitors; Glycerides; Glycerol; Humans; Hydrogen-Ion Concentration; Hydrolysis; Immunoblotting; Monoacylglycerol Lipases; Palmitates; Rabbits; Subcellular Fractions; Tritium | 2009 |
The effects of fatty acid amide hydrolase inhibitors on maintenance of cocaine and food self-administration and on reinstatement of cocaine-seeking and food-taking behavior in rats.
Topics: Amidohydrolases; Animals; Behavior, Animal; Benzamides; Carbamates; Cocaine; Cocaine-Related Disorders; Consummatory Behavior; Dose-Response Relationship, Drug; Eating; Enzyme Inhibitors; Extinction, Psychological; Feeding Behavior; Injections, Intraperitoneal; Male; Phenylmethylsulfonyl Fluoride; Rats; Rats, Wistar; Reinforcement, Psychology; Self Administration | 2009 |
The endogenous cannabinoid, anandamide, inhibits dopamine transporter function by a receptor-independent mechanism.
Topics: Alanine; Arachidonic Acids; Benzamides; Calcium; Cannabinoid Receptor Modulators; Carbamates; Cell Line, Transformed; Dopamine Plasma Membrane Transport Proteins; Dose-Response Relationship, Drug; Endocannabinoids; Enzyme Inhibitors; Humans; Luminescent Proteins; Microscopy, Confocal; Phenylmethylsulfonyl Fluoride; Polyunsaturated Alkamides; Receptors, Cannabinoid; Receptors, Scavenger; Silicone Elastomers; Time Factors; Transfection; Tritium; Tropanes | 2010 |
The dual fatty acid amide hydrolase/TRPV1 blocker, N-arachidonoyl-serotonin, relieves carrageenan-induced inflammation and hyperalgesia in mice.
Topics: Amidohydrolases; Analgesics; Animals; Anti-Inflammatory Agents; Arachidonic Acids; Benzamides; Capsaicin; Carbamates; Carrageenan; Hyperalgesia; Inflammation; Mice; Receptor, Cannabinoid, CB1; Serotonin; TRPV Cation Channels | 2010 |
The hypothalamic endocannabinoid system participates in the secretion of oxytocin and tumor necrosis factor-alpha induced by lipopolysaccharide.
Topics: Analysis of Variance; Animals; Arachidonic Acids; Benzamides; Cannabinoid Receptor Modulators; Carbamates; Endocannabinoids; Enzyme-Linked Immunosorbent Assay; Gene Expression Regulation; Hypothalamus; Indoles; Lipopolysaccharides; Male; Nitric Oxide; Oxytocin; Polyunsaturated Alkamides; Radioimmunoassay; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Tumor Necrosis Factor-alpha | 2010 |
Transient receptor potential vanilloid 1 channels control acetylcholine/2-arachidonoylglicerol coupling in the striatum.
Topics: Acetylcholine; Amidohydrolases; Animals; Arachidonic Acids; Benzamides; Cannabinoid Receptor Modulators; Capsaicin; Carbamates; Corpus Striatum; Endocannabinoids; Enzyme Inhibitors; gamma-Aminobutyric Acid; Glycerides; Inhibitory Postsynaptic Potentials; Mice; Mice, Inbred C57BL; Mice, Knockout; Muscarinic Agonists; Neural Inhibition; Organ Culture Techniques; Polyunsaturated Alkamides; Receptor, Metabotropic Glutamate 5; Receptor, Muscarinic M1; Receptors, Metabotropic Glutamate; Sensory System Agents; Synaptic Transmission; TRPV Cation Channels | 2010 |
Regulation of subthalamic neuron activity by endocannabinoids.
Topics: Animals; Arachidonic Acids; Benzamides; Cannabinoid Receptor Modulators; Carbamates; Cerebral Cortex; Dose-Response Relationship, Drug; Dronabinol; Electrophysiology; Endocannabinoids; Globus Pallidus; Immunohistochemistry; Injections, Intraventricular; Male; Microinjections; Neurons; Piperidines; Polyunsaturated Alkamides; Prefrontal Cortex; Pyrazoles; Rats; Rats, Sprague-Dawley; Rimonabant; Subthalamic Nucleus | 2010 |
Reduction in endocannabinoid tone is a homeostatic mechanism for specific inhibitory synapses.
Topics: Agatoxins; Animals; Arachidonic Acids; Benzamides; Benzoxazines; Biophysics; Calcium; Calcium Channel Blockers; Cannabinoid Receptor Modulators; Carbamates; Conotoxins; Dose-Response Relationship, Drug; Down-Regulation; Drug Interactions; Electric Stimulation; Endocannabinoids; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; gamma-Aminobutyric Acid; Glycerides; Hippocampus; Homeostasis; In Vitro Techniques; Inhibitory Postsynaptic Potentials; Morpholines; Naphthalenes; Nerve Net; Neural Inhibition; Neurons; Patch-Clamp Techniques; Piperidines; Polyamines; Polyunsaturated Alkamides; Pyrazoles; Rats; Receptor, Cannabinoid, CB1; Rimonabant; Sodium Channel Blockers; Synapses; Tetrodotoxin | 2010 |
Inhibitors of monoacylglycerol lipase, fatty-acid amide hydrolase and endocannabinoid transport differentially suppress capsaicin-induced behavioral sensitization through peripheral endocannabinoid mechanisms.
Topics: Amidohydrolases; Animals; Arachidonic Acids; Behavior, Animal; Benzamides; Benzodioxoles; Biological Transport; Cannabinoid Receptor Modulators; Capsaicin; Carbamates; Endocannabinoids; Male; Monoacylglycerol Lipases; Piperidines; Rats; Rats, Sprague-Dawley; Sensory System Agents | 2010 |
Endogenous cannabinoid signaling is essential for stress adaptation.
Topics: Adaptation, Physiological; Analysis of Variance; Animals; Arachidonic Acids; Benzamides; Cannabinoid Receptor Modulators; Carbamates; Corticosterone; Endocannabinoids; Male; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Signal Transduction; Stress, Physiological | 2010 |
Dynamic changes in the TRPA1 selectivity filter lead to progressive but reversible pore dilation.
Topics: Animals; Benzamides; Benzoxazoles; Calcium; Calcium Channels; Carbamates; Cell Membrane; Cell Membrane Permeability; CHO Cells; Cricetinae; Cricetulus; Dogs; Dose-Response Relationship, Drug; Farnesol; Humans; Ion Channel Gating; Isothiocyanates; Kinetics; Meglumine; Membrane Transport Modulators; Nerve Tissue Proteins; Purinergic P2 Receptor Agonists; Quinolinium Compounds; Rats; Receptors, Purinergic P2; Receptors, Purinergic P2X7; Salicylates; Transfection; Transient Receptor Potential Channels; TRPA1 Cation Channel; TRPM Cation Channels; TRPV Cation Channels | 2010 |
Effects of fatty acid amide hydrolase inhibition on neuronal responses to nicotine, cocaine and morphine in the nucleus accumbens shell and ventral tegmental area: involvement of PPAR-alpha nuclear receptors.
Topics: Amidohydrolases; Animals; Benzamides; Carbamates; Cocaine; Dopamine; Evoked Potentials; Male; Morphine; Neurons; Nicotine; Nucleus Accumbens; PPAR alpha; Rats; Rats, Sprague-Dawley; Receptors, Cytoplasmic and Nuclear; Reward; Ventral Tegmental Area | 2010 |
Crystal structure of fatty acid amide hydrolase bound to the carbamate inhibitor URB597: discovery of a deacylating water molecule and insight into enzyme inactivation.
Topics: Amidohydrolases; Benzamides; Carbamates; Catalytic Domain; Crystallography, X-Ray; Enzyme Inhibitors; Models, Molecular; Protein Binding; Protein Structure, Tertiary; Water | 2010 |
Genetic deletion of fatty acid amide hydrolase alters emotional behavior and serotonergic transmission in the dorsal raphe, prefrontal cortex, and hippocampus.
Topics: Action Potentials; Amidohydrolases; Animals; Behavior, Animal; Benzamides; Brain; Cannabinoid Receptor Antagonists; Carbamates; Enzyme Inhibitors; Exploratory Behavior; Hindlimb Suspension; Hippocampus; Male; Maze Learning; Mice; Mice, Inbred C57BL; Mice, Knockout; Mood Disorders; Piperidines; Prefrontal Cortex; Pyrazoles; Raphe Nuclei; Rimonabant; Serotonin; Serotonin Agents; Swimming | 2010 |
Biochanin A, a naturally occurring inhibitor of fatty acid amide hydrolase.
Topics: Amidohydrolases; Animals; Arachidonic Acids; Behavior, Animal; Benzamides; Brain; Cannabinoid Receptor Antagonists; Carbamates; Cell Line, Transformed; Chlorocebus aethiops; COS Cells; Drug Interactions; Endocannabinoids; Extracellular Signal-Regulated MAP Kinases; Formaldehyde; Genistein; Humans; Isoflavones; Liver; Mice; Mice, Inbred ICR; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rats | 2010 |
PET imaging of fatty acid amide hydrolase in the brain: synthesis and biological evaluation of an 11C-labelled URB597 analogue.
Topics: Amidohydrolases; Animals; Benzamides; Brain; Carbamates; Carbon Radioisotopes; Gene Knockout Techniques; Humans; Male; Mice; Positron-Emission Tomography; Quality Control | 2010 |
Reducing endocannabinoid metabolism with the fatty acid amide hydrolase inhibitor, URB597, fails to modify reinstatement of morphine-induced conditioned floor preference and naloxone-precipitated morphine withdrawal-induced conditioned floor avoidance.
Topics: Amidohydrolases; Animals; Avoidance Learning; Benzamides; Cannabinoid Receptor Modulators; Carbamates; Conditioning, Classical; Endocannabinoids; Enzyme Inhibitors; Male; Morphine; Naloxone; Rats; Rats, Sprague-Dawley; Substance Withdrawal Syndrome | 2010 |
Cannabinoid-induced reduction in antral pacemaker frequency: a telemetric study in the ferret.
Topics: Amidohydrolases; Animals; Apomorphine; Benzamides; Biological Clocks; Body Temperature; Cannabinoids; Carbamates; Emetics; Female; Ferrets; Heart Rate; Myoelectric Complex, Migrating; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Telemetry; Vomiting | 2010 |
Effects of URB597, an inhibitor of fatty acid amide hydrolase (FAAH), on analgesic activity of paracetamol.
Topics: Acetaminophen; Amidohydrolases; Analgesics, Non-Narcotic; Animals; Benzamides; Carbamates; Dose-Response Relationship, Drug; Drug Interactions; Linear Models; Male; Mice; Pain Measurement | 2010 |
Hydrolysis of 2-arachidonoylglycerol in Tetrahymena thermophila. Identification and partial characterization of a Monoacylglycerol Lipase-like enzyme.
Topics: Amidohydrolases; Arachidonic Acids; Benzamides; Carbamates; Cell Membrane; Cytosol; Endocannabinoids; Enzyme Inhibitors; Glycerides; Hydrogen-Ion Concentration; Hydrolysis; Kinetics; Molecular Weight; Monoacylglycerol Lipases; Palmitates; Protozoan Proteins; Tetrahymena thermophila | 2010 |
Ethanolamine is a novel STAT-3 dependent cardioprotective agent.
Topics: Amidohydrolases; Animals; Benzamides; Carbamates; Cardiovascular Agents; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme Inhibitors; Ethanolamine; Janus Kinases; Lysophospholipids; Male; Mice; Mice, Knockout; Myocardial Infarction; Myocardial Reperfusion Injury; Myocardium; Phosphorylation; Rats; Rats, Wistar; Sphingosine; STAT3 Transcription Factor; Tyrphostins | 2010 |
Fatty acid amide hydrolase (FAAH) inhibition reduces L-3,4-dihydroxyphenylalanine-induced hyperactivity in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-lesioned non-human primate model of Parkinson's disease.
Topics: Amides; Amidohydrolases; Animals; Benzamides; Callithrix; Carbamates; Disease Models, Animal; Dyskinesia, Drug-Induced; Endocannabinoids; Enzyme Inhibitors; Ethanolamines; Female; Levodopa; Motor Activity; MPTP Poisoning; Oleic Acids; Palmitic Acids; Psychoses, Substance-Induced | 2011 |
Facilitation of CB1 receptor-mediated neurotransmission decreases marble burying behavior in mice.
Topics: Amidohydrolases; Animals; Arachidonic Acids; Behavior, Animal; Benzamides; Benzoxazines; Calcium Channel Blockers; Cannabinoids; Carbamates; Drug Interactions; Endocannabinoids; Male; Mice; Mice, Inbred C57BL; Morpholines; Motor Activity; Naphthalenes; Obsessive-Compulsive Disorder; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Receptor, Cannabinoid, CB1; Synaptic Transmission | 2011 |
Local application of the endocannabinoid hydrolysis inhibitor URB597 reduces nociception in spontaneous and chemically induced models of osteoarthritis.
Topics: Action Potentials; Afferent Pathways; Age Factors; Animals; Arthralgia; Benzamides; Carbamates; Diclofenac; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme Inhibitors; Guinea Pigs; Indoles; Iodoacetic Acid; Male; Nociceptors; Osteoarthritis; Piperidines; Pyrazoles; Rats; Rats, Wistar; Time Factors; Weight-Bearing | 2011 |
The blockade of the transient receptor potential vanilloid type 1 and fatty acid amide hydrolase decreases symptoms and central sequelae in the medial prefrontal cortex of neuropathic rats.
Topics: Amidohydrolases; Amygdala; Animals; Arachidonic Acids; Benzamides; Carbamates; Electric Stimulation; Electrodes; Electrophysiological Phenomena; Male; Microdialysis; Microinjections; Mononeuropathies; Neurons; Nociceptors; Piperidines; Prefrontal Cortex; Pyrazoles; Rats; Rats, Wistar; RNA, Messenger; Serotonin; TRPV Cation Channels | 2011 |
Cannabinoid receptor activation modifies NMDA receptor mediated release of intracellular calcium: implications for endocannabinoid control of hippocampal neural plasticity.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Arachidonic Acids; Benzamides; Benzoxazines; Calcium; Cannabinoid Receptor Modulators; Carbamates; Endocannabinoids; Glycine; Hippocampus; In Vitro Techniques; Morpholines; Naphthalenes; Neuronal Plasticity; Neurons; Phosphorylation; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Receptors, N-Methyl-D-Aspartate; Rimonabant; Ryanodine Receptor Calcium Release Channel; Second Messenger Systems | 2011 |
A FAAH-fetched approach to treat osteoarthritis pain.
Topics: Amidohydrolases; Animals; Benzamides; Carbamates; Enzyme Inhibitors; Osteoarthritis; Pain | 2011 |
Inhibition of fatty acid amide hydrolase modulates anxiety-like behavior in PCP-treated rats.
Topics: Amidohydrolases; Animals; Anti-Anxiety Agents; Anxiety; Behavior, Animal; Benzamides; Carbamates; Enzyme Inhibitors; Male; Phencyclidine; Piperidines; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1 | 2011 |
The fatty acid amide hydrolase inhibitor URB 597: interactions with anandamide in rhesus monkeys.
Topics: Amidohydrolases; Animals; Arachidonic Acids; Benzamides; Carbamates; Discrimination, Psychological; Dronabinol; Drug Interactions; Drug Therapy, Combination; Endocannabinoids; Female; Macaca mulatta; Male; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rimonabant | 2011 |
Disruptive effects of the prototypical cannabinoid Δ⁹-tetrahydrocannabinol and the fatty acid amide inhibitor URB-597 on go/no-go auditory discrimination performance and olfactory reversal learning in rats.
Topics: Animals; Benzamides; Carbamates; Discrimination Learning; Dronabinol; Hearing; Male; Piperidines; Pyrazoles; Rats; Rats, Wistar; Reversal Learning; Rimonabant; Smell | 2011 |
Modulation of anticonvulsant effects of cannabinoid compounds by GABA-A receptor agonist in acute pentylenetetrazole model of seizure in rat.
Topics: Animals; Anticonvulsants; Benzamides; Benzoxazines; Biphenyl Compounds; Brain; Calcium Channel Blockers; Cannabinoids; Carbamates; GABA Antagonists; GABA-A Receptor Agonists; Isonicotinic Acids; Male; Morpholines; Naphthalenes; Pentylenetetrazole; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Seizures | 2011 |
Involvement of endocannabinoids in antidepressant and anti-compulsive effect of fluoxetine in mice.
Topics: Animals; Antidepressive Agents; Arachidonic Acids; Benzamides; Cannabinoid Receptor Modulators; Carbamates; Compulsive Behavior; Depression; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Drug Therapy, Combination; Endocannabinoids; Fluoxetine; Injections, Intraventricular; Male; Mice; Motor Activity; Piperidines; Polyunsaturated Alkamides; Pyrazoles | 2011 |
Memory encoding in hippocampal ensembles is negatively influenced by cannabinoid CB1 receptors.
Topics: Action Potentials; Animals; Benzamides; Benzoxazines; Biphenyl Compounds; CA1 Region, Hippocampal; Cannabinoids; Carbamates; Electric Stimulation; Electrodes, Implanted; Hippocampus; Injections; Male; Memory; Morpholines; Naphthalenes; Neurons; Piperidines; Pyrazoles; Rats; Rats, Long-Evans; Receptor, Cannabinoid, CB1; Rimonabant | 2011 |
The effect of anandamide on uterine nitric oxide synthase activity depends on the presence of the blastocyst.
Topics: Animals; Arachidonic Acids; Benzamides; Blastocyst; Cannabinoid Receptor Modulators; Carbamates; Embryo Implantation; Endocannabinoids; Female; Immunohistochemistry; Nitric Oxide Synthase; Polymerase Chain Reaction; Polyunsaturated Alkamides; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Uterus | 2011 |
Targeting the endocannabinoid system in the amygdala kindling model of temporal lobe epilepsy in mice.
Topics: Amidohydrolases; Amygdala; Animals; Benzamides; Benzoxazines; Carbamates; Disease Models, Animal; Epilepsy, Temporal Lobe; Kindling, Neurologic; Male; Mice; Models, Neurological; Morpholines; Naphthalenes; Receptor, Cannabinoid, CB1; Seizures | 2011 |
Differential role of anandamide and 2-arachidonoylglycerol in memory and anxiety-like responses.
Topics: Amidohydrolases; Analgesics; Animals; Anti-Anxiety Agents; Arachidonic Acids; Benzamides; Benzodioxoles; Cannabinoid Receptor Antagonists; Carbamates; Drug Tolerance; Endocannabinoids; Glycerides; Hippocampus; Maze Learning; Mice; Mice, Inbred Strains; Mice, Knockout; Monoacylglycerol Lipases; Pain Measurement; Piperidines; Polyunsaturated Alkamides; Receptors, Cannabinoid; Recognition, Psychology; TOR Serine-Threonine Kinases | 2011 |
Fatty acid amide hydrolase blockade attenuates the development of collagen-induced arthritis and related thermal hyperalgesia in mice.
Topics: Amidohydrolases; Animals; Arthritis, Experimental; Benzamides; Camphanes; Carbamates; Foot; Genotype; Hot Temperature; Hyperalgesia; Male; Mice; Mice, Inbred DBA; Mice, Knockout; Pain Measurement; Phenotype; Pyrazoles; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2 | 2011 |
Cannabinoids mediate opposing effects on inflammation-induced intestinal permeability.
Topics: Amidohydrolases; Benzamides; Benzodioxoles; Caco-2 Cells; Cannabinoids; Carbamates; Cell Survival; Enzyme Inhibitors; Humans; Indoles; Inflammation; Interferon-gamma; Intestinal Mucosa; Monoacylglycerol Lipases; Permeability; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Tumor Necrosis Factor-alpha | 2012 |
Behavioral effects of fatty acid amide hydrolase inhibition on morphine withdrawal symptoms.
Topics: Amidohydrolases; Animals; Behavior, Animal; Benzamides; Cannabinoid Receptor Modulators; Carbamates; Humans; Male; Morphine Dependence; Random Allocation; Rats; Rats, Wistar; Substance Withdrawal Syndrome | 2011 |
Administration of URB597, oleoylethanolamide or palmitoylethanolamide increases waking and dopamine in rats.
Topics: Amides; Amidohydrolases; Animals; Benzamides; Carbamates; Dopamine; Endocannabinoids; Enzyme Inhibitors; Ethanolamines; Hypothalamus; Male; Oleic Acids; Palmitic Acids; Rats; Sleep; Wakefulness | 2011 |
Fear-induced suppression of nociceptive behaviour and activation of Akt signalling in the rat periaqueductal grey: role of fatty acid amide hydrolase.
Topics: Amidohydrolases; Analgesia; Animals; Arachidonic Acids; Behavior, Animal; Benzamides; Cannabinoid Receptor Modulators; Carbamates; Conditioning, Psychological; Endocannabinoids; Ethanolamines; Exploratory Behavior; Fear; Formaldehyde; Hippocampus; Male; Motor Activity; Nociception; Pain; Periaqueductal Gray; Polyunsaturated Alkamides; Proto-Oncogene Proteins c-akt; Rats; Signal Transduction | 2012 |
L-type calcium channel mediates anticonvulsant effect of cannabinoids in acute and chronic murine models of seizure.
Topics: Acute Disease; Animals; Anticonvulsants; Benzamides; Benzoxazines; Calcium Channels, L-Type; Cannabinoids; Carbamates; Chronic Disease; Diltiazem; Disease Models, Animal; Kindling, Neurologic; Male; Mice; Morpholines; Naphthalenes; Rats; Rats, Wistar; Seizures; Verapamil | 2012 |
Pharmacological inhibition of endocannabinoid degradation modulates the expression of inflammatory mediators in the hypothalamus following an immunological stressor.
Topics: Animals; Benzamides; Cannabinoid Receptor Modulators; Carbamates; Cytokines; Endocannabinoids; Hypothalamus; Inflammation Mediators; Lipopolysaccharides; Male; Rats; Rats, Sprague-Dawley; Stress, Physiological | 2012 |
Inhibition of fatty acid amide hydrolase (FAAH) reduces spinal nociceptive responses and expression of spinal long-term potentiation (LTP).
Topics: Amidohydrolases; Animals; Benzamides; Biophysics; Carbamates; Dose-Response Relationship, Drug; Electric Stimulation; Enzyme Inhibitors; Female; Gene Expression Regulation; Long-Term Potentiation; Naloxone; Narcotic Antagonists; Nerve Fibers; Nociception; Rats; Rats, Sprague-Dawley; Spinal Cord; Time Factors | 2012 |
Endocannabinoid regulation of acute and protracted nicotine withdrawal: effect of FAAH inhibition.
Topics: Acute Disease; Amidohydrolases; Animals; Anxiety; Arachidonic Acids; Benzamides; Brain; Cannabinoid Receptor Modulators; Carbamates; Cotinine; Endocannabinoids; Glycerides; Implants, Experimental; Locomotion; Male; Maze Learning; Nicotine; Polyunsaturated Alkamides; Rats; Rats, Wistar; Substance Withdrawal Syndrome; Tobacco Use Cessation Devices; Weight Gain | 2011 |
Medial prefrontal cortex endocannabinoid system modulates baroreflex activity through CB(1) receptors.
Topics: Amidohydrolases; Animals; Arachidonic Acids; Baroreflex; Benzamides; Blood Pressure; Cannabinoid Receptor Modulators; Carbamates; Endocannabinoids; Glutamic Acid; Male; Piperidines; Prefrontal Cortex; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1 | 2012 |
SK channel modulation rescues striatal plasticity and control over habit in cannabinoid tolerance.
Topics: Animals; Apamin; Benzamides; Biophysics; Cannabinoids; Carbamates; Conditioning, Operant; Corpus Striatum; Cyclohexanols; Dose-Response Relationship, Drug; Dronabinol; Drug Tolerance; Electric Stimulation; Enzyme Inhibitors; Excitatory Postsynaptic Potentials; Guanosine 5'-O-(3-Thiotriphosphate); Habits; Long-Term Synaptic Depression; Male; Mice; Mice, Inbred C57BL; Motor Activity; Okadaic Acid; Patch-Clamp Techniques; Piperidines; Protein Binding; Pyrazoles; Rimonabant; Small-Conductance Calcium-Activated Potassium Channels; Sodium Channel Blockers; Tritium | 2012 |
Endocannabinoid analogues exacerbate marble-burying behavior in mice via TRPV1 receptor.
Topics: Animals; Arachidonic Acids; Behavior, Animal; Benzamides; Cannabinoids; Carbamates; Endocannabinoids; Mice; Motor Activity; Polyunsaturated Alkamides; TRPV Cation Channels | 2012 |
Vascular metabolism of anandamide to arachidonic acid affects myogenic constriction in response to intraluminal pressure elevation.
Topics: Analysis of Variance; Animals; Arachidonic Acids; Arterioles; Benzamides; Benzoxazines; Blood Pressure; Caproates; Capsaicin; Carbamates; Dose-Response Relationship, Drug; Endocannabinoids; Flavanones; Immunohistochemistry; In Vitro Techniques; Indomethacin; Morpholines; Muscle Contraction; Muscle, Smooth, Vascular; Naphthalenes; Polyunsaturated Alkamides; Rats | 2012 |
Prefrontal cortical anandamide signaling coordinates coping responses to stress through a serotonergic pathway.
Topics: Action Potentials; Adaptation, Psychological; Animals; Arachidonic Acids; Benzamides; Cannabinoid Receptor Antagonists; Carbamates; Endocannabinoids; Enzyme Inhibitors; Fenclonine; Glycerides; Male; Microinjections; Piperidines; Polyunsaturated Alkamides; Prefrontal Cortex; Pyrazoles; Raphe Nuclei; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Serotonergic Neurons; Signal Transduction; Stress, Psychological | 2012 |
Differences in spontaneously avoiding or approaching mice reflect differences in CB1-mediated signaling of dorsal striatal transmission.
Topics: Animals; Behavior, Animal; Benzamides; Carbamates; Corpus Striatum; Male; Maze Learning; Mice; Mice, Inbred C57BL; Neurons; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Signal Transduction; Synaptic Transmission | 2012 |
Peripheral FAAH inhibition causes profound antinociception and protects against indomethacin-induced gastric lesions.
Topics: Amidohydrolases; Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Benzamides; Cannabinoids; Carbamates; Disease Models, Animal; Enzyme Inhibitors; Hyperalgesia; Indomethacin; Male; Mice; Pain; Pyridazines; Sciatic Nerve; Stomach Ulcer; Urea | 2012 |
The association of N-palmitoylethanolamine with the FAAH inhibitor URB597 impairs melanoma growth through a supra-additive action.
Topics: Amides; Animals; Arachidonic Acids; Benzamides; Cannabinoid Receptor Modulators; Carbamates; Cell Death; Cell Line, Tumor; Cell Survival; Disease Models, Animal; Drug Synergism; Endocannabinoids; Ethanolamines; Male; Mass Spectrometry; Melanoma, Experimental; Mice; Mice, Inbred C57BL; Palmitic Acids; Polyunsaturated Alkamides; Random Allocation; Reverse Transcriptase Polymerase Chain Reaction; Skin Neoplasms | 2012 |
Enhanced vasorelaxant effects of the endocannabinoid-like mediator, oleamide, in hypertension.
Topics: Amidohydrolases; Animals; Aorta; Benzamides; Biomimetic Materials; Cannabinoid Receptor Modulators; Capsaicin; Carbamates; Cyclooxygenase Inhibitors; Endocannabinoids; Endothelium, Vascular; Hypertension; In Vitro Techniques; Male; NG-Nitroarginine Methyl Ester; Oleic Acids; Rats; Receptor, Cannabinoid, CB1; TRPV Cation Channels; Vasodilator Agents | 2012 |
Effects of alterations in cannabinoid signaling, alone and in combination with morphine, on pain-elicited and pain-suppressed behavior in mice.
Topics: Amidohydrolases; Analgesics; Animals; Arachidonic Acids; Benzamides; Cannabinoid Receptor Modulators; Carbamates; Cyclohexanols; Endocannabinoids; Male; Mice; Mice, Inbred C57BL; Morphine; Nociception; Pain; Polyunsaturated Alkamides; Receptor, Cannabinoid, CB1 | 2012 |
The fatty acid amide hydrolase inhibitor URB597 exerts anti-inflammatory effects in hippocampus of aged rats and restores an age-related deficit in long-term potentiation.
Topics: Aging; Amidohydrolases; Animals; Anti-Inflammatory Agents, Non-Steroidal; Benzamides; Carbamates; Hippocampus; Long-Term Potentiation; Male; Microglia; Rats; Rats, Wistar | 2012 |
Cannabinoid type-1 receptor reduces pain and neurotoxicity produced by chemotherapy.
Topics: Activating Transcription Factor 3; Animals; Antineoplastic Agents; Arachidonic Acids; Benzamides; Cannabinoid Receptor Modulators; Carbamates; Cells, Cultured; Cisplatin; Disease Models, Animal; Drug Interactions; Endocannabinoids; Enzyme Inhibitors; Ganglia, Spinal; Hyperalgesia; Male; Mice; Mice, Inbred C3H; Morpholines; Motor Activity; Neurites; Neurotoxicity Syndromes; Peripheral Nervous System Diseases; Polyunsaturated Alkamides; Pyrazoles; Receptor, Cannabinoid, CB1; TRPV Cation Channels | 2012 |
Lack of effect of chronic pre-treatment with the FAAH inhibitor URB597 on inflammatory pain behaviour: evidence for plastic changes in the endocannabinoid system.
Topics: Amides; Amidohydrolases; Animals; Arachidonic Acids; Behavior, Animal; Benzamides; Carbamates; Disease Models, Animal; Drug Administration Schedule; Endocannabinoids; Ethanolamines; Inflammation; Male; Oleic Acids; Pain; Palmitic Acids; Polyunsaturated Alkamides; Rats; Rats, Sprague-Dawley; Spinal Cord | 2012 |
Dysfunction in fatty acid amide hydrolase is associated with depressive-like behavior in Wistar Kyoto rats.
Topics: Amidohydrolases; Animals; Arachidonic Acids; Benzamides; Brain; Brain-Derived Neurotrophic Factor; Cannabinoid Receptor Modulators; Carbamates; Depressive Disorder; Disease Models, Animal; Endocannabinoids; Enzyme Inhibitors; Frontal Lobe; Genetic Predisposition to Disease; Hippocampus; Male; Phospholipase D; Polyunsaturated Alkamides; Rats; Rats, Inbred WKY; Rats, Wistar; Receptor, Cannabinoid, CB1; Species Specificity; Swimming | 2012 |
Endothelium-dependent mechanisms of the vasodilatory effect of the endocannabinoid, anandamide, in the rat pulmonary artery.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Amidohydrolases; Animals; Anisoles; Apamin; Arachidonic Acids; Benzamides; Benzyl Compounds; Cannabinoid Receptor Antagonists; Capsaicin; Carbamates; Charybdotoxin; Cyclohexanes; Endocannabinoids; Endothelium, Vascular; Imidazoles; Indoles; Indomethacin; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Piperidines; Polyunsaturated Alkamides; Potassium Channel Blockers; Potassium Chloride; Prostaglandin-Endoperoxide Synthases; Pulmonary Artery; Pyrazoles; Rats; Rats, Wistar; Receptors, Cannabinoid; Receptors, Epoprostenol; Tetraethylammonium; TRPV Cation Channels; Vasodilation | 2012 |
N-arachidonoyl-serotonin in the basolateral amygdala increases anxiolytic behavior in the elevated plus maze.
Topics: Amygdala; Analysis of Variance; Animals; Anxiety Disorders; Arachidonic Acids; Benzamides; Capsaicin; Carbamates; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Inhibitors; Exploratory Behavior; Male; Maze Learning; Rats; Rats, Sprague-Dawley; Serotonin; TRPV Cation Channels | 2012 |
Hyperactivity induced by the dopamine D2/D3 receptor agonist quinpirole is attenuated by inhibitors of endocannabinoid degradation in mice.
Topics: Animals; Benzamides; Carbamates; Dopamine Agonists; Endocannabinoids; Male; Mice; Mice, Inbred C57BL; Psychomotor Agitation; Quinpirole; Receptors, Dopamine D2; Receptors, Dopamine D3; Stereotyped Behavior | 2013 |
Inhibition of fatty acid amide hydrolase by URB597 attenuates the anxiolytic-like effect of acetaminophen in the mouse elevated plus-maze test.
Topics: Acetaminophen; Amidohydrolases; Animals; Anti-Anxiety Agents; Anxiety; Arachidonic Acids; Benzamides; Carbamates; Disease Models, Animal; Dose-Response Relationship, Drug; Injections, Intraperitoneal; Male; Maze Learning; Mice; Mice, Inbred BALB C; Motor Activity; Piperidines; Pyrazoles; Rimonabant | 2012 |
Prenatal stress and peripubertal stimulation of the endocannabinoid system differentially regulate emotional responses and brain metabolism in mice.
Topics: Anhedonia; Animals; Anxiety; Benzamides; Body Weight; Brain; Carbamates; Corticosterone; Drinking; Emotions; Endocannabinoids; Female; Locomotion; Male; Mice; Pregnancy; Puberty; Stress, Psychological; Time Factors | 2012 |
The endocannabinoid, anandamide, augments Notch-1 signaling in cultured cortical neurons exposed to amyloid-β and in the cortex of aged rats.
Topics: Aging; Alzheimer Disease; Amyloid beta-Peptides; Amyloid Precursor Protein Secretases; Animals; Arachidonic Acids; Benzamides; Carbamates; Cells, Cultured; Cerebral Cortex; Endocannabinoids; Gene Expression Regulation, Enzymologic; Glycerides; Hippocampus; Male; Membrane Glycoproteins; Neurons; Peptide Fragments; Polyunsaturated Alkamides; Rats; Rats, Wistar; Receptor, Notch1; Signal Transduction; Up-Regulation | 2012 |
Covalent inhibition of recombinant human carboxylesterase 1 and 2 and monoacylglycerol lipase by the carbamates JZL184 and URB597.
Topics: Benzamides; Benzodioxoles; Carbamates; Carboxylesterase; Carboxylic Ester Hydrolases; Enzyme Reactivators; Hep G2 Cells; Humans; Kinetics; Monoacylglycerol Lipases; Paraoxon; Phosphorylation; Piperidines; Recombinant Proteins | 2012 |
The FAAH inhibitor URB597 efficiently reduces tyrosine hydroxylase expression through CB₁- and FAAH-independent mechanisms.
Topics: Amidohydrolases; Animals; Animals, Outbred Strains; Anti-Anxiety Agents; Antidepressive Agents; Benzamides; Cannabidiol; Cannabinoid Receptor Antagonists; Carbamates; Cell Line, Tumor; Corpus Striatum; Dopaminergic Neurons; Endocannabinoids; Enzyme Inhibitors; Gene Expression Regulation, Enzymologic; Genes, Reporter; Hippocampus; Mice; Nerve Tissue Proteins; Peroxisome Proliferator-Activated Receptors; Promoter Regions, Genetic; Receptor, Cannabinoid, CB1; Tyrosine 3-Monooxygenase | 2013 |
Subventricular zone neural progenitors protect striatal neurons from glutamatergic excitotoxicity.
Topics: 4-Aminopyridine; Amidohydrolases; Animals; Arachidonic Acids; Benzamides; Carbamates; Corpus Striatum; Disease Models, Animal; Dronabinol; Endocannabinoids; Epilepsy; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Ganciclovir; Glutamic Acid; Lateral Ventricles; Lipopolysaccharides; Mice; Mice, Inbred C57BL; Mice, Transgenic; Neural Stem Cells; Neuroprotective Agents; Polyunsaturated Alkamides; Stem Cells; Stroke | 2012 |
Quantitative LC-MS/MS analysis of arachidonoyl amino acids in mouse brain with treatment of FAAH inhibitor.
Topics: Amidohydrolases; Amino Acids; Animals; Arachidonic Acids; Benzamides; Brain; Carbamates; Chromatography, High Pressure Liquid; Endocannabinoids; Enzyme Inhibitors; gamma-Aminobutyric Acid; Glycerides; Mice; Polyunsaturated Alkamides; Tandem Mass Spectrometry | 2013 |
Endocannabinoids in amygdala and nucleus accumbens mediate social play reward in adolescent rats.
Topics: Amidohydrolases; Amygdala; Analysis of Variance; Animals; Animals, Newborn; Benzamides; Cannabinoid Receptor Agonists; Carbamates; Dose-Response Relationship, Drug; Endocannabinoids; Enzyme Inhibitors; Gene Expression Regulation; Interpersonal Relations; Male; Nucleus Accumbens; Phospholipase D; Phosphorylation; Piperidines; Play and Playthings; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Reward; Rimonabant | 2012 |
Alterations in endocannabinoid tone following chemotherapy-induced peripheral neuropathy: effects of endocannabinoid deactivation inhibitors targeting fatty-acid amide hydrolase and monoacylglycerol lipase in comparison to reference analgesics following c
Topics: Amidohydrolases; Analgesics; Animals; Antineoplastic Agents; Arachidonic Acids; Benzamides; Benzodioxoles; Cannabinoids; Carbamates; Cisplatin; Endocannabinoids; Enzyme Inhibitors; Ganglia, Spinal; Glycerides; Hyperalgesia; Lipid Metabolism; Male; Monoacylglycerol Lipases; Peripheral Nervous System Diseases; Piperidines; Polyunsaturated Alkamides; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; RNA, Messenger; Spinal Cord; TRPV Cation Channels | 2013 |
Fatty acid amide hydrolase deficiency enhances intraplaque neutrophil recruitment in atherosclerotic mice.
Topics: Amides; Amidohydrolases; Animals; Aorta; Aortic Diseases; Apolipoproteins E; Arachidonic Acids; Atherosclerosis; Benzamides; Carbamates; Cells, Cultured; Chemokine CXCL1; Cholesterol; Disease Models, Animal; Endocannabinoids; Enzyme Inhibitors; Ethanolamines; Genotype; Inflammation Mediators; Interferon-gamma; Matrix Metalloproteinase 9; Mice; Mice, Inbred C57BL; Mice, Knockout; Muscle, Smooth, Vascular; Neutrophil Infiltration; Neutrophils; Oleic Acids; Palmitic Acids; Phenotype; Plaque, Atherosclerotic; Polyunsaturated Alkamides; Spleen; T-Lymphocytes, Regulatory; Time Factors; Tumor Necrosis Factor-alpha | 2013 |
Inhibition of fatty acid amide hydrolase activates Nrf2 signalling and induces heme oxygenase 1 transcription in breast cancer cells.
Topics: Active Transport, Cell Nucleus; Amidohydrolases; Antineoplastic Agents; Arachidonic Acids; Benzamides; Breast Neoplasms; Carbamates; Cell Survival; Dose-Response Relationship, Drug; Endocannabinoids; Enzyme Induction; Enzyme Inhibitors; Female; Gene Expression Regulation, Neoplastic; Heme Oxygenase-1; Humans; MCF-7 Cells; NF-E2-Related Factor 2; Polyunsaturated Alkamides; RNA Interference; Signal Transduction; Transcription, Genetic; Transfection | 2013 |
Effects of cannabinoids and endocannabinoid hydrolysis inhibition on pentylenetetrazole-induced seizure and electroencephalographic activity in rats.
Topics: Animals; Benzamides; Benzoxazines; Cannabinoids; Carbamates; Convulsants; Disease Models, Animal; Electroencephalography; Endocannabinoids; Hydrolysis; Male; Morpholines; Naphthalenes; Pentylenetetrazole; Rats; Rats, Wistar; Seizures | 2013 |
Inhibition of endocannabinoid degradation in experimental endotoxemia reduces leukocyte adhesion and improves capillary perfusion in the gut.
Topics: Amidohydrolases; Animals; Benzamides; Cannabinoid Receptor Antagonists; Capillaries; Carbamates; Cell Adhesion; Disease Models, Animal; Endocannabinoids; Endotoxemia; Indoles; Intestinal Mucosa; Intestines; Leukocytes; Lipopolysaccharides; Male; Rats; Rats, Inbred Lew; Receptor, Cannabinoid, CB2 | 2013 |
Quantum mechanics/molecular mechanics modeling of fatty acid amide hydrolase reactivation distinguishes substrate from irreversible covalent inhibitors.
Topics: Acylation; Amidohydrolases; Benzamides; Carbamates; Enzyme Activation; Enzyme Inhibitors; Enzyme Stability; Models, Molecular; Protein Conformation; Quantum Theory | 2013 |
PPARα regulates cholinergic-driven activity of midbrain dopamine neurons via a novel mechanism involving α7 nicotinic acetylcholine receptors.
Topics: Action Potentials; alpha7 Nicotinic Acetylcholine Receptor; Analysis of Variance; Animals; Animals, Newborn; Benzamides; Bridged Bicyclo Compounds; Carbamates; Cholinergic Agents; Dihydro-beta-Erythroidine; Dopaminergic Neurons; Drug Interactions; Enzyme Inhibitors; Ethanolamines; Excitatory Amino Acid Antagonists; In Vitro Techniques; Ligands; Male; Patch-Clamp Techniques; PPAR alpha; Pyrimidines; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic; Swimming; Tyrosine 3-Monooxygenase; Ventral Tegmental Area | 2013 |
Phencyclidine-induced social withdrawal results from deficient stimulation of cannabinoid CB₁ receptors: implications for schizophrenia.
Topics: Amidohydrolases; Amygdala; Animals; Arachidonic Acids; Benzamides; Cannabinoid Receptor Agonists; Cannabinoid Receptor Antagonists; Carbamates; Cyclohexanols; Dose-Response Relationship, Drug; Endocannabinoids; Male; Phencyclidine; Piperidines; Polyunsaturated Alkamides; Prefrontal Cortex; Pyrazoles; Quinazolinones; Rats; Receptor, Cannabinoid, CB1; Receptor, Cholecystokinin B; Rimonabant; Schizophrenia; Social Behavior | 2013 |
Full inhibition of spinal FAAH leads to TRPV1-mediated analgesic effects in neuropathic rats and possible lipoxygenase-mediated remodeling of anandamide metabolism.
Topics: Amides; Amidohydrolases; Analgesia; Animals; Arachidonate 15-Lipoxygenase; Arachidonic Acids; Benzamides; Calcium Signaling; Carbamates; Diterpenes; Endocannabinoids; Ethanolamines; Flavanones; Glycerides; HEK293 Cells; Humans; Hyperalgesia; Injections, Spinal; Lipoxygenase Inhibitors; Male; Neuralgia; Oleic Acids; Palmitic Acids; Polyunsaturated Alkamides; Posterior Horn Cells; Rats; Rats, Wistar; Sciatic Nerve; Spinal Cord; TRPV Cation Channels | 2013 |
The fatty acid amide hydrolase inhibitor, URB597, promotes retinal ganglion cell neuroprotection in a rat model of optic nerve axotomy.
Topics: Age Factors; Amidohydrolases; Animals; Axotomy; Benzamides; Carbamates; Cell Count; Disease Models, Animal; Endocannabinoids; Indoles; Microglia; Morpholines; Neural Pathways; Neuroprotective Agents; Optic Nerve Diseases; Pyrazoles; Rats; Rats, Inbred F344; Retina; Retinal Ganglion Cells; Stilbamidines | 2013 |
Increased anandamide uptake by sensory neurons contributes to hyperalgesia in a model of cancer pain.
Topics: Animals; Arachidonic Acids; Benzamides; Brain Neoplasms; Cannabinoid Receptor Antagonists; Carbamates; Cells, Cultured; Coculture Techniques; Disease Models, Animal; Endocannabinoids; Enzyme Inhibitors; Fibrosarcoma; Fluorescent Dyes; Ganglia, Spinal; Hyperalgesia; Indoles; Lactones; Male; Mice; Mice, Inbred C3H; Pain; Pain Threshold; Polyunsaturated Alkamides; Sensory Receptor Cells; Statistics, Nonparametric; Tritium | 2013 |
Effects of compounds that interfere with the endocannabinoid system on behaviors predictive of anxiolytic and panicolytic activities in the elevated T-maze.
Topics: Alprazolam; Animals; Anti-Anxiety Agents; Behavior, Animal; Benzamides; Benzodiazepines; Benzoxazines; Carbamates; Endocannabinoids; Locomotion; Male; Maze Learning; Morpholines; Naphthalenes; Panic; Piperidines; Pyrazoles; Rats; Receptor, Cannabinoid, CB1 | 2013 |
The effects of anandamide signaling enhanced by the FAAH inhibitor URB597 on coping styles in rats.
Topics: Adaptation, Psychological; Amidohydrolases; Animals; Arachidonic Acids; Behavior, Animal; Benzamides; Carbamates; Endocannabinoids; Male; Maze Learning; Polyunsaturated Alkamides; Rats; Rats, Wistar; Signal Transduction | 2013 |
Anandamide modulates the neuroendocrine responses induced by extracellular volume expansion.
Topics: Amidohydrolases; Animals; Arachidonic Acids; Benzamides; Carbamates; Endocannabinoids; Gene Expression Regulation; Infusions, Intraventricular; Male; Median Eminence; Neuroprotective Agents; Nitrates; Oxytocin; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; RNA, Messenger; Saline Solution, Hypertonic; Vasopressins | 2013 |
Effects of endocannabinoid and endovanilloid systems on aversive memory extinction.
Topics: Amidohydrolases; Animals; Arachidonic Acids; Benzamides; Carbamates; Endocannabinoids; Enzyme Inhibitors; Extinction, Psychological; Fear; Freezing Reaction, Cataleptic; Male; Memory; Mice, Inbred C57BL; Polyunsaturated Alkamides; Receptor, Cannabinoid, CB1; Social Dominance; Stress, Psychological; Time Factors; TRPV Cation Channels | 2013 |
Effects of the fatty acid amide hydrolase inhibitor URB597 on coping behavior under challenging conditions in mice.
Topics: Adaptation, Psychological; Amidohydrolases; Animals; Arachidonic Acids; Benzamides; Carbamates; Electrodes, Implanted; Electroencephalography; Electromyography; Electroshock; Endocannabinoids; Enzyme Inhibitors; Escape Reaction; Freezing Reaction, Cataleptic; Male; Mice, Inbred Strains; Motor Activity; Polyunsaturated Alkamides; Restraint, Physical; Sleep; Stress, Psychological | 2014 |
Endocannabinoid anandamide mediates hypoxic pulmonary vasoconstriction.
Topics: Amidohydrolases; Analysis of Variance; Animals; Arachidonic Acids; Benzamides; Blotting, Western; Carbamates; Chromatography, Liquid; DNA Primers; Endocannabinoids; Hypertension, Pulmonary; Hypoxia; Immunohistochemistry; Lung; Mice; Mice, Knockout; Myocytes, Smooth Muscle; Polyunsaturated Alkamides; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction; Vasoconstriction | 2013 |
Monounsaturated fatty acids generated via stearoyl CoA desaturase-1 are endogenous inhibitors of fatty acid amide hydrolase.
Topics: Amidohydrolases; Analysis of Variance; Animals; Arachidonic Acids; Benzamides; Carbamates; Endocannabinoids; Fatty Acids, Monounsaturated; Feedback, Physiological; Insulin Resistance; Liver; Male; Mice; Mice, Inbred C57BL; Obesity; Polyunsaturated Alkamides; Receptor, Cannabinoid, CB1; Stearoyl-CoA Desaturase | 2013 |
Endocannabinoids underlie reconsolidation of hedonic memories in Wistar rats.
Topics: Amidohydrolases; Animals; Benzamides; Benzoxazines; Carbamates; Conditioning, Psychological; Cues; Endocannabinoids; Indoles; Male; Memory; Morphine; Morpholines; Naphthalenes; Piperidines; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Recurrence; Rimonabant; Secondary Prevention | 2014 |
Inhibition of endocannabinoid-degrading enzyme fatty acid amide hydrolase increases atherosclerotic plaque vulnerability in mice.
Topics: Amidohydrolases; Animals; Apolipoproteins E; Arachidonic Acids; Benzamides; Carbamates; Cell Movement; Diet, High-Fat; Dietary Fats; Endocannabinoids; Enzyme Inhibitors; Gene Expression; Macrophages; Mice; Mice, Knockout; Neutrophils; Plaque, Atherosclerotic; Polyunsaturated Alkamides; Superoxides | 2014 |
Prenatal corticosterone and adolescent URB597 administration modulate emotionality and CB1 receptor expression in mice.
Topics: Animals; Benzamides; Brain; Carbamates; Corticosterone; Emotions; Female; Hypothalamo-Hypophyseal System; Male; Mice; Motor Activity; Pituitary-Adrenal System; Pregnancy; Prenatal Exposure Delayed Effects; Receptor, Cannabinoid, CB1 | 2014 |
Actions of the dual FAAH/MAGL inhibitor JZL195 in a murine inflammatory pain model.
Topics: Amidohydrolases; Analgesics; Analysis of Variance; Animals; Arthritis, Experimental; Benzamides; Benzoxazines; Carbamates; Disease Models, Animal; Dose-Response Relationship, Drug; Exploratory Behavior; Male; Mice; Mice, Inbred C57BL; Morpholines; Motor Activity; Naphthalenes; Pain; Pain Measurement; Piperazines; Piperidines; Pyrazoles; Time Factors | 2014 |
Effects of the fatty acid amide hydrolase inhibitor URB597 on pain-stimulated and pain-depressed behavior in rats.
Topics: Amidohydrolases; Analgesics; Animals; Arachidonic Acids; Behavior, Animal; Benzamides; Brain; Carbamates; Conditioning, Operant; Depression; Dose-Response Relationship, Drug; Electric Stimulation; Endocannabinoids; Enzyme Inhibitors; Implantable Neurostimulators; Injections, Intraperitoneal; Lactic Acid; Male; Pain; Polyunsaturated Alkamides; Rats; Rats, Sprague-Dawley; Receptors, Cannabinoid; Self Administration | 2014 |
Elevation of endogenous anandamide impairs LTP, learning, and memory through CB1 receptor signaling in mice.
Topics: Amidohydrolases; Animals; Arachidonic Acids; Benzamides; Calcium-Calmodulin-Dependent Protein Kinase Type 4; Carbamates; Cyclic AMP Response Element-Binding Protein; Endocannabinoids; Glycerides; Learning; Long-Term Potentiation; Male; MAP Kinase Signaling System; Maze Learning; Memory; Mice; Mice, Inbred C57BL; Mice, Knockout; Phosphorylation; Polyunsaturated Alkamides; Protein Processing, Post-Translational; Receptor, Cannabinoid, CB1; Spatial Memory | 2014 |
Antidepressants and changes in concentration of endocannabinoids and N-acylethanolamines in rat brain structures.
Topics: Acetylcysteine; Amides; Amidohydrolases; Animals; Antidepressive Agents; Arachidonic Acids; Benzamides; Brain; Carbamates; Citalopram; Endocannabinoids; Enzyme Inhibitors; Ethanolamines; Expectorants; Glycerides; Imipramine; Male; Oleic Acids; Palmitic Acids; Polyunsaturated Alkamides; Rats, Wistar; Thiazepines | 2014 |
Effects of endogenous cannabinoid anandamide on cardiac Na⁺/Ca²⁺ exchanger.
Topics: Animals; Arachidonic Acids; Benzamides; Calcium Channel Blockers; Carbamates; Cells, Cultured; Endocannabinoids; HEK293 Cells; Humans; Male; Microscopy, Confocal; Myocytes, Cardiac; Patch-Clamp Techniques; Polyunsaturated Alkamides; Rats; Rats, Wistar; Sodium-Calcium Exchanger | 2014 |
Prior stimulation of the endocannabinoid system prevents methamphetamine-induced dopaminergic neurotoxicity in the striatum through activation of CB2 receptors.
Topics: Animals; Arachidonic Acids; Benzamides; Benzodioxoles; Cannabinoid Receptor Modulators; Carbamates; Central Nervous System Stimulants; Dronabinol; Endocannabinoids; Enzyme Inhibitors; Glycerides; Male; Methamphetamine; Mice, Inbred C57BL; Neostriatum; Neurotoxicity Syndromes; Piperidines; Polyunsaturated Alkamides; Random Allocation; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Tumor Necrosis Factor-alpha; Tyrosine 3-Monooxygenase | 2014 |
Long-term consequences of perinatal fatty acid amino hydrolase inhibition.
Topics: Amidohydrolases; Animals; Behavior, Animal; Benzamides; Carbamates; Dose-Response Relationship, Drug; Enzyme Inhibitors; Female; Mice; Mice, Inbred ICR; Pregnancy | 2014 |
Fatty acid amide hydrolase (FAAH) inhibitors exert pharmacological effects, but lack antinociceptive efficacy in rats with neuropathic spinal cord injury pain.
Topics: Amidohydrolases; Analgesics; Animals; Arachidonic Acids; Benzamides; Benzoxazines; Brain; Carbamates; Endocannabinoids; Enzyme Inhibitors; Hindlimb; Male; Morpholines; Naphthalenes; Neuralgia; Pain Measurement; Pain Threshold; Piperidines; Polyunsaturated Alkamides; Pyridines; Rats, Sprague-Dawley; Spinal Cord; Spinal Cord Injuries; Treatment Outcome | 2014 |
The CB1 receptor antagonist AM251 impairs reconsolidation of pavlovian fear memory in the rat basolateral amygdala.
Topics: Amidohydrolases; Animals; Auditory Perception; Basolateral Nuclear Complex; Benzamides; Bicuculline; Cannabinoid Receptor Antagonists; Carbamates; Conditioning, Classical; Electroshock; Enzyme Inhibitors; Fear; GABA-A Receptor Antagonists; Male; Memory; Piperidines; Pyrazoles; Rats; Receptor, Cannabinoid, CB1; Receptors, GABA-A | 2014 |
Attenuation of serotonin-induced itch responses by inhibition of endocannabinoid degradative enzymes, fatty acid amide hydrolase and monoacylglycerol lipase.
Topics: Amidohydrolases; Animals; Arachidonic Acids; Benzamides; Benzodioxoles; Camphanes; Carbamates; Endocannabinoids; Enzyme Inhibitors; Male; Mice; Mice, Inbred BALB C; Monoacylglycerol Lipases; Piperidines; Pruritus; Pyrazoles; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Serotonin | 2015 |
Strain- and context-dependent effects of the anandamide hydrolysis inhibitor URB597 on social behavior in rats.
Topics: Age Factors; Amidohydrolases; Analysis of Variance; Animals; Behavior, Animal; Benzamides; Carbamates; Conditioning, Psychological; Dose-Response Relationship, Drug; Male; Rats; Rats, Sprague-Dawley; Rats, Wistar; Social Behavior; Species Specificity; Vocalization, Animal | 2014 |
Increased angiotensin II contraction of the uterine artery at early gestation in a transgenic model of hypertensive pregnancy is reduced by inhibition of endocannabinoid hydrolysis.
Topics: Amidohydrolases; Angiotensin II; Animals; Arachidonic Acids; Benzamides; Benzodioxoles; Blood Pressure; Carbamates; Disease Models, Animal; Endocannabinoids; Female; Glycerides; Humans; Hydrolysis; Hypertension, Pregnancy-Induced; Male; Monoglycerides; Piperidines; Polyunsaturated Alkamides; Pregnancy; Pregnancy, Animal; Rats; Rats, Sprague-Dawley; Rats, Transgenic; Uterine Artery; Vasoconstriction | 2014 |
PET imaging of fatty acid amide hydrolase with [(18)F]DOPP in nonhuman primates.
Topics: Amidohydrolases; Animals; Benzamides; Blood-Brain Barrier; Brain; Carbamates; Endocannabinoids; Fluorine Radioisotopes; Magnetic Resonance Imaging; Models, Chemical; Oxazoles; Papio; Positron-Emission Tomography; Primates; Tissue Distribution | 2014 |
Endocannabinoid modulation by FAAH and monoacylglycerol lipase within the analgesic circuitry of the periaqueductal grey.
Topics: Amidohydrolases; Animals; Arachidonic Acids; Benzamides; Benzodioxoles; Carbamates; Endocannabinoids; Female; Glycerides; In Vitro Techniques; Inhibitory Postsynaptic Potentials; Male; Monoacylglycerol Lipases; Neurons; Pain; Periaqueductal Gray; Piperidines; Polyunsaturated Alkamides; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Synaptic Transmission | 2014 |
Therapeutic potential of inhibitors of endocannabinoid degradation for the treatment of stress-related hyperalgesia in an animal model of chronic pain.
Topics: Amidohydrolases; Analgesics, Non-Narcotic; Animals; Anxiety; Benzamides; Benzodioxoles; Brain; Carbamates; Chronic Pain; Depression; Disease Models, Animal; Endocannabinoids; Enzyme Inhibitors; Hyperalgesia; Male; Mice, Inbred C57BL; Monoacylglycerol Lipases; Nerve Growth Factor; Piperidines; Stress, Psychological; Uncertainty | 2015 |
Role of the basolateral amygdala in mediating the effects of the fatty acid amide hydrolase inhibitor URB597 on HPA axis response to stress.
Topics: Analysis of Variance; Animals; Basolateral Nuclear Complex; Benzamides; Carbamates; Corticotropin-Releasing Hormone; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme Inhibitors; Gene Expression Regulation; Hypothalamo-Hypophyseal System; Male; Paraventricular Hypothalamic Nucleus; Piperidines; Pituitary-Adrenal System; Pro-Opiomelanocortin; Pyrazoles; Rats; RNA, Messenger; Stress, Psychological; Swimming; Time Factors | 2014 |
Blockade of monoacylglycerol lipase inhibits oligodendrocyte excitotoxicity and prevents demyelination in vivo.
Topics: Amidohydrolases; Animals; Benzamides; Benzodioxoles; Cannabinoid Receptor Modulators; Carbamates; Demyelinating Diseases; Monoacylglycerol Lipases; Multiple Sclerosis; Oligodendroglia; Piperidines; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1 | 2015 |
Endocannabinoid degradation inhibition improves neurobehavioral function, blood-brain barrier integrity, and neuroinflammation following mild traumatic brain injury.
Topics: Animals; Arachidonic Acids; Benzamides; Benzodioxoles; Blood-Brain Barrier; Blotting, Western; Brain Injuries; Carbamates; Disease Models, Animal; Endocannabinoids; Glycerides; Immunohistochemistry; Inflammation; Male; Neuroprotective Agents; Piperidines; Polyunsaturated Alkamides; Rats; Rats, Sprague-Dawley; Real-Time Polymerase Chain Reaction; Recovery of Function | 2015 |
Interaction between the cholecystokinin and endogenous cannabinoid systems in cued fear expression and extinction retention.
Topics: Amidohydrolases; Animals; Benzamides; Cannabinoid Receptor Antagonists; Carbamates; Cholecystokinin; Conditioning, Psychological; Cues; Dose-Response Relationship, Drug; Extinction, Psychological; Fear; Male; Mice; Mice, Knockout; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Receptor, Cholecystokinin B; Rimonabant | 2015 |
FAAH-mediated modulation of TLR3-induced neuroinflammation in the rat hippocampus.
Topics: Amidohydrolases; Animals; Benzamides; Carbamates; Chromatography, Liquid; Cytokines; Drug Administration Routes; Encephalitis; Enzyme Inhibitors; Gene Expression Regulation; Hippocampus; Interferon Inducers; Male; Poly I-C; Rats; Rats, Sprague-Dawley; RNA, Messenger; Tandem Mass Spectrometry; Toll-Like Receptor 3 | 2014 |
Tapping into the endocannabinoid system to ameliorate acute inflammatory flares and associated pain in mouse knee joints.
Topics: Acute Disease; Amidohydrolases; Animals; Arthralgia; Benzamides; Carbamates; Carrageenan; Endocannabinoids; Hindlimb; Hyperalgesia; Indoles; Inflammation; Kaolin; Knee Joint; Male; Mice, Inbred C57BL; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Synovitis; Weight-Bearing | 2014 |
Anti-aversive role of the endocannabinoid system in the periaqueductal gray stimulation model of panic attacks in rats.
Topics: Amidohydrolases; Animals; Anxiety; Arachidonic Acids; Behavior, Animal; Benzamides; Carbamates; Disease Models, Animal; Endocannabinoids; Enzyme Inhibitors; Male; N-Methylaspartate; Panic Disorder; Periaqueductal Gray; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1 | 2015 |
Development of [(11)C]MFTC for PET imaging of fatty acid amide hydrolase in rat and monkey brains.
Topics: Amidohydrolases; Animals; Benzamides; Brain; Carbamates; Carbon Radioisotopes; Enzyme Inhibitors; Kidney; Liver; Lung; Macaca mulatta; Mice; Positron-Emission Tomography; Radiopharmaceuticals; Rats; Species Specificity | 2015 |
Normal aging in rats and pathological aging in human Alzheimer's disease decrease FAAH activity: modulation by cannabinoid agonists.
Topics: Aged; Aged, 80 and over; Aging; Alzheimer Disease; Amidohydrolases; Amyloid beta-Peptides; Animals; Arachidonic Acids; Benzamides; Benzoxazines; Cannabinoid Receptor Agonists; Cannabinoids; Carbamates; Case-Control Studies; Cerebral Cortex; Endocannabinoids; Enzyme Inhibitors; Female; Frontal Lobe; Humans; In Vitro Techniques; Male; Middle Aged; Morpholines; Naphthalenes; Polyunsaturated Alkamides; Rats; Rats, Wistar; Synaptosomes | 2014 |
Attenuation of persistent pain-related behavior by fatty acid amide hydrolase (FAAH) inhibitors in a rat model of HIV sensory neuropathy.
Topics: Amidohydrolases; Amines; Analgesics; Animals; Benzamides; Carbamates; Cyclohexanecarboxylic Acids; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme Inhibitors; Gabapentin; gamma-Aminobutyric Acid; HIV Envelope Protein gp120; HIV Infections; Hyperalgesia; Male; Nociception; Piperidines; Pyridines; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Recombinant Proteins; Sciatic Neuropathy | 2015 |
Endogenous cannabinoid release within prefrontal-limbic pathways affects memory consolidation of emotional training.
Topics: Amidohydrolases; Animals; Arachidonic Acids; Avoidance Learning; Benzamides; Carbamates; Emotions; Endocannabinoids; Glycerides; Limbic System; Memory; Polyunsaturated Alkamides; Prefrontal Cortex; Rats; Receptor, Cannabinoid, CB1 | 2014 |
Inhibition of anandamide hydrolysis attenuates nociceptor sensitization in a murine model of chemotherapy-induced peripheral neuropathy.
Topics: Amidohydrolases; Animals; Arachidonic Acids; Benzamides; Cannabinoid Receptor Antagonists; Carbamates; Cisplatin; Endocannabinoids; Hydrolysis; Indoles; Male; Mice; Morpholines; Nerve Fibers, Unmyelinated; Nociception; Nociceptors; Peripheral Nervous System Diseases; Polyunsaturated Alkamides; Pyrazoles; Skin | 2015 |
Interaction between the endocannabinoid and serotonergic system in the exhibition of head twitch response in four mouse strains.
Topics: Amphetamines; Animals; Benzamides; Cannabinoid Receptor Agonists; Carbamates; Head Movements; Male; Mice; Mice, Inbred C57BL; Serotonin Receptor Agonists; Species Specificity | 2015 |
Chronic stimulation of the tone of endogenous anandamide reduces cue- and stress-induced relapse in rats.
Topics: Amidohydrolases; Animals; Arachidonic Acids; Benzamides; Carbamates; Cocaine; Cocaine-Related Disorders; Cues; Disease Models, Animal; Dopamine Uptake Inhibitors; Drug-Seeking Behavior; Endocannabinoids; Enzyme Inhibitors; Male; Polyunsaturated Alkamides; Rats, Sprague-Dawley; Recurrence; Self Administration; Stress, Physiological; Yohimbine | 2014 |
Increasing endocannabinoid levels in the ventral pallidum restore aberrant dopamine neuron activity in the subchronic PCP rodent model of schizophrenia.
Topics: Animals; Basal Forebrain; Benzamides; Carbamates; Central Nervous System Agents; Disease Models, Animal; Dopaminergic Neurons; Endocannabinoids; Hippocampus; Male; Microelectrodes; Phencyclidine; Rats, Sprague-Dawley; Schizophrenia; Sodium Channel Blockers; Tetrodotoxin; Ventral Tegmental Area | 2014 |
Inhibition of anandamide hydrolysis enhances noradrenergic and GABAergic transmission in the prefrontal cortex and basolateral amygdala of rats subjected to acute swim stress.
Topics: Analysis of Variance; Animals; Arachidonic Acids; Basolateral Nuclear Complex; Benzamides; Carbamates; Chromatography, High Pressure Liquid; Disease Models, Animal; Endocannabinoids; Extracellular Fluid; gamma-Aminobutyric Acid; Male; Microdialysis; Norepinephrine; Polyunsaturated Alkamides; Prefrontal Cortex; Rats; Rats, Wistar; Stress, Psychological; Swimming | 2015 |
Cannabinoid CB1 receptors in the dorsal hippocampus and prelimbic medial prefrontal cortex modulate anxiety-like behavior in rats: additional evidence.
Topics: Animals; Anxiety; Arachidonic Acids; Benzamides; Carbamates; Disease Models, Animal; Drinking; Drinking Behavior; Electric Stimulation; Enzyme Inhibitors; Hippocampus; Male; Maze Learning; Prefrontal Cortex; Rats; Rats, Wistar; Reaction Time; Receptor, Cannabinoid, CB1; Statistics, Nonparametric; Tail; Time Factors; Vocalization, Animal | 2015 |
Role of endocannabinoid signalling in the dorsolateral periaqueductal grey in the modulation of distinct panic-like responses.
Topics: Animals; Arachidonic Acids; Benzamides; Carbamates; Disease Models, Animal; Dose-Response Relationship, Drug; Endocannabinoids; Escape Reaction; Male; Maze Learning; Panic Disorder; Periaqueductal Gray; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Signal Transduction | 2015 |
Increased Contextual Fear Conditioning in iNOS Knockout Mice: Additional Evidence for the Involvement of Nitric Oxide in Stress-Related Disorders and Contribution of the Endocannabinoid System.
Topics: Animals; Arachidonic Acids; Benzamides; Benzoxazines; Cannabinoid Receptor Agonists; Cannabinoid Receptor Antagonists; Carbamates; Conditioning, Psychological; Endocannabinoids; Enzyme Inhibitors; Extinction, Psychological; Fear; Freezing Reaction, Cataleptic; Hippocampus; Indazoles; Male; Mice, Inbred C57BL; Mice, Knockout; Morpholines; Naphthalenes; Nitric Oxide; Nitric Oxide Synthase Type II; Polyunsaturated Alkamides; Prefrontal Cortex; Pyrazoles; Receptor, Cannabinoid, CB1; RNA, Messenger; Stress, Psychological | 2015 |
Effects of URB597 as an inhibitor of fatty acid amide hydrolase on WIN55, 212-2-induced learning and memory deficits in rats.
Topics: Amidohydrolases; Animals; Benzamides; Benzoxazines; Carbamates; Learning; Male; Memory Disorders; Morpholines; Naphthalenes; Nootropic Agents; Piperidines; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Retention, Psychology; Rimonabant | 2015 |
A multi-target approach for pain treatment: dual inhibition of fatty acid amide hydrolase and TRPV1 in a rat model of osteoarthritis.
Topics: Activating Transcription Factor 3; Amidohydrolases; Anilides; Animals; Arachidonic Acids; Benzamides; Capsaicin; Carbamates; Cinnamates; Disease Models, Animal; Endocannabinoids; Ganglia, Spinal; Gene Expression; Hyperalgesia; Inflammation; Interleukin-6; Lumbar Vertebrae; Male; Osteoarthritis; Pain; Pain Management; Pain Measurement; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; TRPV Cation Channels | 2015 |
Effects of Fatty Acid Amide Hydrolase (FAAH) Inhibitors in Non-Human Primate Models of Nicotine Reward and Relapse.
Topics: Animals; Benzamides; Biphenyl Compounds; Brain; Carbamates; Cues; Dopamine; Dose-Response Relationship, Drug; Drug-Seeking Behavior; Extinction, Psychological; Male; Mixed Function Oxygenases; Models, Animal; Nicotine; Nicotinic Agonists; Rats; Rats, Sprague-Dawley; Recurrence; Reward; Saimiri; Self Administration; Time Factors | 2015 |
Attenuation of kainic acid-induced status epilepticus by inhibition of endocannabinoid transport and degradation in guinea pigs.
Topics: Amidohydrolases; Animals; Anticonvulsants; Arachidonic Acids; Benzamides; Biological Transport; Brain; Cannabinoid Receptor Antagonists; Carbamates; Endocannabinoids; Guinea Pigs; Kainic Acid; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Seizures; Status Epilepticus | 2015 |
Cannabinoid receptor agonist WIN55,212-2 and fatty acid amide hydrolase inhibitor URB597 suppress chronic cerebral hypoperfusion-induced neuronal apoptosis by inhibiting c-Jun N-terminal kinase signaling.
Topics: Animals; Apoptosis; Benzamides; Benzoxazines; Calcium Channel Blockers; Carbamates; Carotid Stenosis; Cerebral Cortex; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Inhibitors; JNK Mitogen-Activated Protein Kinases; Male; Maze Learning; Morpholines; Naphthalenes; Neurons; Phosphopyruvate Hydratase; Rats; Rats, Sprague-Dawley; Signal Transduction; Time Factors | 2015 |
Inhibition of FAAH reduces nitroglycerin-induced migraine-like pain and trigeminal neuronal hyperactivity in mice.
Topics: Amidohydrolases; Analgesics; Animals; Arachidonic Acids; Benzamides; Cannabinoid Receptor Antagonists; Carbamates; Disease Models, Animal; Dose-Response Relationship, Drug; Endocannabinoids; Enzyme Inhibitors; Hyperalgesia; Male; Mice, Inbred C57BL; Mice, Knockout; Migraine Disorders; Monoacylglycerol Lipases; Nitroglycerin; Pain Measurement; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Rimonabant; Touch; Trigeminal Nuclei | 2015 |
Enhanced function of inhibitory presynaptic cannabinoid CB1 receptors on sympathetic nerves of DOCA-salt hypertensive rats.
Topics: Animals; Benzamides; Blood Pressure; Cannabinoid Receptor Agonists; Cannabinoid Receptor Antagonists; Carbamates; Desoxycorticosterone Acetate; Hypertension; Male; Nephrectomy; Phenylephrine; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Receptors, Presynaptic; Sodium, Dietary; Sympathetic Nervous System | 2015 |
Enhancement of endocannabinoid signaling protects against cocaine-induced neurotoxicity.
Topics: Animals; Benzamides; Carbamates; Cell Death; Cells, Cultured; Cocaine; Dose-Response Relationship, Drug; Endocannabinoids; Hippocampus; Male; Mice; Mice, Inbred C57BL; Neuroprotective Agents; Receptor, Cannabinoid, CB1; Signal Transduction | 2015 |
Cannabidiol effects in the prepulse inhibition disruption induced by amphetamine.
Topics: Amphetamine; Animals; Benzamides; Cannabidiol; Carbamates; Inhibition, Psychological; Male; Mice; Nucleus Accumbens; Prepulse Inhibition; Reflex, Startle | 2015 |
Endocannabinoid-mediated improvement on a test of aversive memory in a mouse model of fragile X syndrome.
Topics: Amidohydrolases; Animals; Anxiety; Arachidonic Acids; Avoidance Learning; Benzamides; Cannabinoid Receptor Antagonists; Carbamates; Disease Models, Animal; Endocannabinoids; Enzyme Inhibitors; Fragile X Mental Retardation Protein; Fragile X Syndrome; Male; Memory; Mice, Inbred C57BL; Mice, Knockout; Piperidines; Polyunsaturated Alkamides; Propofol; Pyrazoles; Receptor, Cannabinoid, CB1; Receptors, GABA-A; Social Behavior | 2015 |
Inhibition of fatty-acid amide hydrolyse (FAAH) exerts cognitive improvements in male but not female rats.
Topics: Amidohydrolases; Animals; Behavior, Animal; Benzamides; Brain; Carbamates; Cognition; Endocannabinoids; Enzyme Inhibitors; Exploratory Behavior; Female; Male; Memory, Short-Term; Motor Activity; Nootropic Agents; Rats, Sprague-Dawley; Recognition, Psychology; Sex Factors | 2015 |
Inhibition of FAAH confers increased stem cell migration via PPARα.
Topics: Adipose Tissue; Amides; Amidohydrolases; Arachidonic Acids; Benzamides; Carbamates; Cell Movement; Cells, Cultured; Endocannabinoids; Enzyme Inhibitors; Ethanolamines; Glycerides; Humans; Mesenchymal Stem Cells; Oleic Acids; Palmitic Acids; Polyunsaturated Alkamides; PPAR alpha; Receptor, Cannabinoid, CB1; Serotonin | 2015 |
Fatty acid amide hydrolase inhibitor URB597 prevented tolerance and cognitive deficits induced by chronic morphine administration in rats.
Topics: Amidohydrolases; Analgesics, Opioid; Animals; Avoidance Learning; Benzamides; Carbamates; Cognition Disorders; Drug Tolerance; Enzyme Inhibitors; Male; Memory Disorders; Morphine; Morphine Dependence; Nociception; Psychotropic Drugs; Random Allocation; Rats, Wistar | 2016 |
Interference with acute nausea and anticipatory nausea in rats by fatty acid amide hydrolase (FAAH) inhibition through a PPARα and CB1 receptor mechanism, respectively: a double dissociation.
Topics: Acute Disease; Amidohydrolases; Animals; Anticipation, Psychological; Benzamides; Carbamates; Male; Nausea; Piperidines; PPAR alpha; Pyridines; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1 | 2015 |
Anandamide mediates cognitive judgement bias in rats.
Topics: Acoustic Stimulation; Analysis of Variance; Animals; Arachidonic Acids; Benzamides; Bias; Calcium Channel Blockers; Carbamates; Cognition; Conditioning, Psychological; Cues; Discrimination, Psychological; Dose-Response Relationship, Drug; Drug Interactions; Endocannabinoids; Judgment; Male; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rats | 2016 |
Actions of the dual FAAH/MAGL inhibitor JZL195 in a murine neuropathic pain model.
Topics: Amidohydrolases; Animals; Benzamides; Benzodioxoles; Benzoxazines; Carbamates; Disease Models, Animal; Dose-Response Relationship, Drug; Hyperalgesia; Male; Mice; Monoacylglycerol Lipases; Morpholines; Naphthalenes; Neuralgia; Piperazines; Piperidines | 2016 |
Characterisation of (R)-2-(2-Fluorobiphenyl-4-yl)-N-(3-Methylpyridin-2-yl)Propanamide as a Dual Fatty Acid Amide Hydrolase: Cyclooxygenase Inhibitor.
Topics: Amides; Amidohydrolases; Animals; Arachidonic Acid; Arachidonic Acids; Benzamides; Brain; Carbamates; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Endocannabinoids; Flurbiprofen; Humans; Hydrolysis; Interferon-gamma; Ionomycin; Isoenzymes; Lipid Metabolism; Lipopolysaccharides; Male; Mice; Polyunsaturated Alkamides; Prostaglandins; RAW 264.7 Cells; Stereoisomerism | 2015 |
Training-Associated Emotional Arousal Shapes Endocannabinoid Modulation of Spatial Memory Retrieval in Rats.
Topics: Animals; Arachidonic Acids; Arousal; Benzamides; Benzoxazines; Calcium Channel Blockers; Cannabinoid Receptor Agonists; Carbamates; Corticosterone; Dose-Response Relationship, Drug; Emotions; Endocannabinoids; Enzyme Inhibitors; Glycerides; Hippocampus; Male; Maze Learning; Mental Recall; Morpholines; Naphthalenes; Rats; Rats, Sprague-Dawley; Spatial Learning; Stress, Psychological; Temperature | 2015 |
Endocannabinoid signaling mediates oxytocin-driven social reward.
Topics: Analysis of Variance; Animals; Arachidonic Acids; Autism Spectrum Disorder; Benzamides; Benzodiazepines; Camphanes; Carbamates; Clozapine; Cocaine; Endocannabinoids; Immunohistochemistry; Infusions, Intraventricular; Lipids; Male; Mice; Mice, Inbred C57BL; Nucleus Accumbens; Oxytocin; Piperazines; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Receptors, Cannabinoid; Reward; Signal Transduction; Social Behavior | 2015 |
Synthesis and Preliminary PET Imaging Studies of a FAAH Radiotracer ([¹¹C]MPPO) Based on α-Ketoheterocyclic Scaffold.
Topics: Amidohydrolases; Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Benzamides; Brain; Carbamates; Carbon Radioisotopes; Enzyme Inhibitors; Male; Mice; Mice, Transgenic; Positron-Emission Tomography; Radiopharmaceuticals; Rats; Rats, Sprague-Dawley; Tissue Distribution | 2016 |
THC and endocannabinoids differentially regulate neuronal activity in the prefrontal cortex and hippocampus in the subchronic PCP model of schizophrenia.
Topics: Animals; Arachidonic Acids; Benzamides; Carbamates; Disease Models, Animal; Dronabinol; Endocannabinoids; Hippocampus; Male; Phencyclidine; Polyunsaturated Alkamides; Prefrontal Cortex; Rats; Rats, Sprague-Dawley; Schizophrenia; Up-Regulation | 2016 |
Inhibition of anandamide hydrolysis dampens the neuroendocrine response to stress in neonatal rats subjected to suboptimal rearing conditions.
Topics: Adrenocorticotropic Hormone; Amidohydrolases; Animals; Animals, Newborn; Arachidonic Acids; Behavior, Animal; Benzamides; Carbamates; Corticosterone; Endocannabinoids; Hydrolysis; Hypothalamus; Male; Neurosecretory Systems; Paraventricular Hypothalamic Nucleus; Polyunsaturated Alkamides; Rats; Rats, Sprague-Dawley; Restraint, Physical; Stress, Physiological; Stress, Psychological | 2016 |
Fluorine nuclear magnetic resonance-based assay in living mammalian cells.
Topics: Amidohydrolases; Benzamides; Carbamates; Fluorine; HEK293 Cells; Humans; Inhibitory Concentration 50; Nuclear Magnetic Resonance, Biomolecular | 2016 |
N-(3,4-Dimethylisoxazol-5-yl)piperazine-4-[4-(2-fluoro-4-[(11)C]methylphenyl)thiazol-2-yl]-1-carboxamide: A promising positron emission tomography ligand for fatty acid amide hydrolase.
Topics: Amidohydrolases; Animals; Benzamides; Brain; Carbamates; Carbon Radioisotopes; Humans; Ligands; Mice; Molecular Structure; Piperazines; Positron-Emission Tomography; Radiopharmaceuticals; Rats; Thiazoles; Tissue Distribution | 2016 |
The fatty acid amide hydrolase inhibitor URB597 modulates serotonin-dependent emotional behaviour, and serotonin1A and serotonin2A/C activity in the hippocampus.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Action Potentials; Adrenergic Agents; Amidohydrolases; Animals; Benzamides; Benzoxazines; Benzylamines; Calcium Channel Blockers; Carbamates; Dose-Response Relationship, Drug; Emotions; Hippocampus; Immobility Response, Tonic; Locomotion; Male; Maze Learning; Morpholines; Naphthalenes; Rats; Rats, Sprague-Dawley; Receptors, Serotonin; Serotonergic Neurons; Serotonin; Serotonin Agents | 2016 |
Self-administration of the anandamide transport inhibitor AM404 by squirrel monkeys.
Topics: Animals; Arachidonic Acids; Benzamides; Cannabinoid Receptor Antagonists; Carbamates; Cocaine; Dose-Response Relationship, Drug; Dronabinol; Drug-Seeking Behavior; Endocannabinoids; Male; Nicotine; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Reinforcement, Psychology; Reward; Rimonabant; Saimiri; Self Administration | 2016 |
The effects anandamide signaling in the prelimbic cortex and basolateral amygdala on coping with environmental stimuli in rats.
Topics: Adaptation, Psychological; Animals; Anti-Anxiety Agents; Anxiety; Arachidonic Acids; Basolateral Nuclear Complex; Benzamides; Carbamates; Endocannabinoids; Glycerides; Male; Polyunsaturated Alkamides; Prefrontal Cortex; Rats; Rats, Wistar; Signal Transduction | 2016 |
Comparisons of Δ9-Tetrahydrocannabinol and Anandamide on a Battery of Cognition-Related Behavior in Nonhuman Primates.
Topics: Animals; Arachidonic Acids; Attention; Behavior, Animal; Benzamides; Carbamates; Cognition; Discrimination Learning; Dose-Response Relationship, Drug; Dronabinol; Endocannabinoids; Learning; Male; Memory, Short-Term; Motivation; Piperidines; Polyunsaturated Alkamides; Psychomotor Performance; Pyrazoles; Reversal Learning; Rimonabant; Saimiri | 2016 |
Attenuation of cue-induced reinstatement of nicotine seeking by URB597 through cannabinoid CB1 receptor in rats.
Topics: Amidohydrolases; Animals; Arachidonic Acids; Benzamides; Cannabinoid Receptor Antagonists; Carbamates; Cues; Drug-Seeking Behavior; Endocannabinoids; Male; Nicotine; Piperidines; Polyunsaturated Alkamides; PPAR alpha; Pyrazoles; Rats; Rats, Long-Evans; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Rimonabant; Tobacco Use Disorder | 2016 |
Age-specific influences of chronic administration of the fatty acid amide hydrolase inhibitor URB597 on cardiovascular parameters and organ hypertrophy in DOCA-salt hypertensive rats.
Topics: Amidohydrolases; Animals; Benzamides; Blood Pressure; Carbamates; Desoxycorticosterone Acetate; Heart; Heart Rate; Hypertension; Hypertrophy; Kidney; Male; Rats; Rats, Wistar | 2016 |
Sex differences in hippocampal response to endocannabinoids after exposure to severe stress.
Topics: Amidohydrolases; Amygdala; Animals; Benzamides; Carbamates; Disease Models, Animal; Endocannabinoids; Enzyme Inhibitors; Fear; Female; Hippocampus; Long-Term Potentiation; Male; Prefrontal Cortex; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Sex Characteristics; Stress Disorders, Post-Traumatic; Stress, Psychological | 2016 |
Fatty acid amide hydrolase inhibitors confer anti-invasive and antimetastatic effects on lung cancer cells.
Topics: Aged; Amidohydrolases; Animals; Apoptosis; Arachidonic Acids; Benzamides; Biomarkers, Tumor; Brain Neoplasms; Carbamates; Carcinoma, Non-Small-Cell Lung; Cell Movement; Cell Proliferation; Female; Gene Expression Regulation, Enzymologic; Humans; Lung Neoplasms; Male; Mice; Mice, Nude; Neoplasm Invasiveness; Receptor, Cannabinoid, CB2; Serotonin; Tissue Inhibitor of Metalloproteinase-1; Tumor Cells, Cultured; Xenograft Model Antitumor Assays | 2016 |
Encapsulation of cannabinoid drugs in nanostructured lipid carriers.
Topics: Benzamides; Cannabinoids; Carbamates; Drug Carriers; Lipids; Nanostructures; Piperidines; Pyrazoles; Rimonabant | 2016 |
Protective role of cannabinoid CB1 receptors and vascular effects of chronic administration of FAAH inhibitor URB597 in DOCA-salt hypertensive rats.
Topics: Amidohydrolases; Animals; Aorta; Arachidonic Acids; Benzamides; Blood Pressure; Capsaicin; Carbamates; Desoxycorticosterone Acetate; Dose-Response Relationship, Drug; Drug Interactions; Hypertension; Male; Mesenteric Arteries; Morpholines; Phenylephrine; Pyrazoles; Rats; Receptor, Cannabinoid, CB1; Sodium Chloride; Vasoconstriction; Vasodilation | 2016 |
Crosstalk between liver antioxidant and the endocannabinoid systems after chronic administration of the FAAH inhibitor, URB597, to hypertensive rats.
Topics: Amidohydrolases; Animals; Benzamides; Carbamates; Catalase; Desoxycorticosterone Acetate; Endocannabinoids; Glutathione; Glutathione Disulfide; Glutathione Peroxidase; Glutathione Transferase; Hypertension; Liver; Male; Monoacylglycerol Lipases; Phospholipases A2; Rats, Wistar; Reactive Oxygen Species; Receptor, Cannabinoid, CB1; Superoxide Dismutase | 2016 |
Distinct neuronal activation patterns are associated with PCP-induced social withdrawal and its reversal by the endocannabinoid-enhancing drug URB597.
Topics: Amidohydrolases; Animals; Benzamides; Brain; Carbamates; Endocannabinoids; Exploratory Behavior; Male; Neurons; Phencyclidine; Proto-Oncogene Proteins c-fos; Rats, Wistar; Schizophrenia; Schizophrenic Psychology; Social Behavior | 2016 |
URB597 inhibits oxidative stress induced by alcohol binging in the prefrontal cortex of adolescent rats.
Topics: Amidohydrolases; Animals; Benzamides; Binge Drinking; Carbamates; Ethanol; Male; Oxidative Stress; Prefrontal Cortex; Rats; Rats, Wistar | 2016 |
Fatty acid amide hydrolase inhibition for the symptomatic relief of Parkinson's disease.
Topics: Amidohydrolases; Animals; Arachidonic Acids; Benzamides; Cannabinoid Receptor Agonists; Carbamates; Disease Models, Animal; Endocannabinoids; Male; Mice; Mice, Inbred C57BL; Parkinsonian Disorders; Polyunsaturated Alkamides; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2 | 2016 |
Cannabinoid receptor agonist WIN55,212-2 and fatty acid amide hydrolase inhibitor URB597 may protect against cognitive impairment in rats of chronic cerebral hypoperfusion via PI3K/AKT signaling.
Topics: Animals; Benzamides; Benzoxazines; Cannabinoid Receptor Agonists; Carbamates; Cognitive Dysfunction; Fatty Acids; Glycogen Synthase Kinase 3; Long-Term Potentiation; Male; Maze Learning; Mixed Function Oxygenases; Morpholines; Naphthalenes; Neuroprotective Agents; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Rats, Sprague-Dawley; Receptors, Cannabinoid; Signal Transduction | 2016 |
Involvement of endocannabinoid neurotransmission in the bed nucleus of stria terminalis in cardiovascular responses to acute restraint stress in rats.
Topics: Acute Disease; Animals; Benzamides; Benzodioxoles; Carbamates; Cardiovascular System; Dose-Response Relationship, Drug; Endocannabinoids; Male; Piperidines; Pyrazoles; Rats; Rats, Wistar; Restraint, Physical; Septal Nuclei; Stress, Psychological; Structure-Activity Relationship; Synaptic Transmission | 2016 |
Orchestrated activation of mGluR5 and CB1 promotes neuroprotection.
Topics: Animals; Benzamides; Benzodioxoles; Calcium; Carbamates; Enzyme Activation; Extracellular Signal-Regulated MAP Kinases; Gene Knockdown Techniques; Intracellular Space; Mice, Inbred C57BL; Models, Biological; Neurons; Neuroprotection; Phosphorylation; Piperidines; Presynaptic Terminals; Proto-Oncogene Proteins c-akt; Pyrazoles; Receptor, Cannabinoid, CB1; Receptor, Metabotropic Glutamate 5; Synapses | 2016 |
Emotional arousal state influences the ability of amygdalar endocannabinoid signaling to modulate anxiety.
Topics: Animals; Anxiety; Arachidonic Acids; Arousal; Basolateral Nuclear Complex; Benzamides; Cannabinoid Receptor Agonists; Carbamates; Corticosterone; Emotions; Endocannabinoids; Epinephrine; Glycerides; Male; Polyunsaturated Alkamides; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Signal Transduction | 2016 |
Chronic FAAH inhibition during nicotine abstinence alters habenular CB1 receptor activity and precipitates depressive-like behaviors.
Topics: Amidohydrolases; Animals; Benzamides; Carbamates; Depression; Habenula; Male; Nicotine; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Self Administration; Substance Withdrawal Syndrome | 2017 |
Chronic stress leads to epigenetic dysregulation in the neuropeptide-Y and cannabinoid CB1 receptor genes in the mouse cingulate cortex.
Topics: Animals; Benzamides; Carbamates; Epigenesis, Genetic; Gyrus Cinguli; Humans; Male; Mice; Mice, Inbred C57BL; Neuropeptide Y; Receptor, Cannabinoid, CB1; Stress, Psychological | 2017 |
Effects of alprazolam and cannabinoid-related compounds in an animal model of panic attack.
Topics: Alprazolam; Analgesics; Animals; Arachidonic Acids; Benzamides; Benzoxazines; Blood Pressure; Cannabinoids; Carbamates; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme Inhibitors; Escape Reaction; Heart Rate; Hypnotics and Sedatives; Locomotion; Male; Mice; Morpholines; Naphthalenes; Panic Disorder; Potassium Cyanide; Rats, Wistar; Serotonin | 2017 |
URB597 improves cognitive impairment induced by chronic cerebral hypoperfusion by inhibiting mTOR-dependent autophagy.
Topics: Amidohydrolases; Animals; Apoptosis; Autophagy; Benzamides; CA1 Region, Hippocampal; Carbamates; Carotid Artery, Common; Cerebrovascular Disorders; Cognition; Cognitive Dysfunction; Disease Models, Animal; Long-Term Potentiation; Male; Maze Learning; Neurons; Neuroprotective Agents; Nootropic Agents; Phosphorylation; Rats, Sprague-Dawley; TOR Serine-Threonine Kinases | 2017 |
URB597 and the Cannabinoid WIN55,212-2 Reduce Behavioral and Neurochemical Deficits Induced by MPTP in Mice: Possible Role of Redox Modulation and NMDA Receptors.
Topics: Animals; Benzamides; Benzoxazines; Carbamates; Corpus Striatum; Dopamine; Down-Regulation; Lipid Peroxidation; Locomotion; Male; Mice; Morpholines; MPTP Poisoning; Naphthalenes; Oxidation-Reduction; Protein Carbonylation; Receptors, N-Methyl-D-Aspartate; Substantia Nigra; Tyrosine 3-Monooxygenase | 2017 |
Effect of inhibition of fatty acid amide hydrolase on MPTP-induced dopaminergic neuronal damage.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Amidohydrolases; Animals; Benzamides; Carbamates; Disease Models, Animal; Dopaminergic Neurons; Male; Mice; Mice, Inbred C57BL; Motor Skills; Neuroprotective Agents; Parkinson Disease; Substantia Nigra; Tyrosine 3-Monooxygenase | 2019 |
URB597 reduces biochemical, behavioral and morphological alterations in two neurotoxic models in rats.
Topics: Amidohydrolases; Animals; Apomorphine; Behavior, Animal; Benzamides; Body Weight; Carbamates; Injections; Lipid Peroxidation; Male; Motor Skills; Neostriatum; Neuroprotective Agents; Neurotoxicity Syndromes; Nitro Compounds; Oxidopamine; Propionates; Rats; Rats, Wistar | 2017 |
Fatty acid amide hydrolase inhibitors produce rapid anti-anxiety responses through amygdala long-term depression in male rodents.
Topics: Amidohydrolases; Amygdala; Animals; Anti-Anxiety Agents; Benzamides; Carbamates; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Long-Term Synaptic Depression; Male; Mutation; Piperidines; Pyridines; Rats; Receptor, Cannabinoid, CB1 | 2017 |
The role of CB
Topics: Amidohydrolases; Arachidonic Acids; Benzamides; Benzodioxoles; Caco-2 Cells; Carbamates; Colorectal Neoplasms; Cytokines; Electric Impedance; Endocannabinoids; Gene Expression Regulation; Glycerides; Humans; Inflammation; Intestinal Mucosa; Intestines; Monoacylglycerol Lipases; Oxygen Consumption; Permeability; Piperidines; Polyunsaturated Alkamides; Receptor, Cannabinoid, CB1; Tissue Culture Techniques | 2017 |
Chronic inhibition of fatty acid amide hydrolase by URB597 produces differential effects on cardiac performance in normotensive and hypertensive rats.
Topics: Amidohydrolases; Animals; Antihypertensive Agents; Benzamides; Blood Pressure; Carbamates; Cyclohexanols; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme Inhibitors; Heart; Isoproterenol; Male; Myocardial Contraction; Rats; Rats, Inbred SHR; Rats, Wistar; Structure-Activity Relationship | 2017 |
Inhibition of SENP3 by URB597 ameliorates neurovascular unit dysfunction in rats with chronic cerebral hypoperfusion.
Topics: Animals; Apoptosis; Benzamides; Brain; Brain Ischemia; Carbamates; Chronic Disease; Disease Models, Animal; Endopeptidases; Male; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Up-Regulation | 2017 |
Lipid nanoparticles for administration of poorly water soluble neuroactive drugs.
Topics: Animals; Benzamides; Brain; Carbamates; Drug Carriers; Drug Liberation; Glycerides; Kinetics; Lipids; Male; Nanoparticles; Particle Size; Polysorbates; Rats; Rats, Wistar; Solubility; Tissue Distribution; Triglycerides; Water | 2017 |
Early blockade of joint inflammation with a fatty acid amide hydrolase inhibitor decreases end-stage osteoarthritis pain and peripheral neuropathy in mice.
Topics: Amidohydrolases; Animals; Arthralgia; Benzamides; Carbamates; Inflammation; Knee Joint; Male; Mice; Mice, Inbred C57BL; Osteoarthritis; Peripheral Nervous System Diseases | 2017 |
Sensitization of C-fiber nociceptors in mice with sickle cell disease is decreased by local inhibition of anandamide hydrolysis.
Topics: Anemia, Sickle Cell; Animals; Arachidonic Acids; Benzamides; Carbamates; Disease Models, Animal; Endocannabinoids; Enzyme Inhibitors; Evoked Potentials; Hemoglobins; Humans; Hydrolysis; Hyperalgesia; Indoles; Male; Mice; Mice, Transgenic; Morpholines; Nerve Fibers, Unmyelinated; Nociceptors; Pain Threshold; Polyunsaturated Alkamides; Pyrazoles; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2 | 2017 |
The effects of chronic FAAH inhibition on myocardial lipid metabolism in normotensive and DOCA-salt hypertensive rats.
Topics: Amidohydrolases; Animals; Benzamides; Blood Pressure; Carbamates; Chromatography, Gas; Chromatography, Liquid; Coronary Vessels; Desoxycorticosterone Acetate; Disease Models, Animal; Endocannabinoids; Fatty Acids; Hypertension; Lipid Metabolism; Male; Myocardium; Myocytes, Cardiac; Rats; Rats, Wistar | 2017 |
The effects of enhancing endocannabinoid signaling and blocking corticotrophin releasing factor receptor in the amygdala and hippocampus on the consolidation of a stressful event.
Topics: Amidohydrolases; Animals; Anxiety; Basolateral Nuclear Complex; Benzamides; CA1 Region, Hippocampal; Carbamates; Disease Models, Animal; Endocannabinoids; Male; Memory Consolidation; Nootropic Agents; Pyrimidines; Pyrroles; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Receptors, Corticotropin-Releasing Hormone; Reflex, Startle; RNA, Messenger; Stress Disorders, Post-Traumatic; Stress, Psychological | 2017 |
Cannabinoids prevent the differential long-term effects of exposure to severe stress on hippocampal- and amygdala-dependent memory and plasticity.
Topics: Amidohydrolases; Amygdala; Animals; Avoidance Learning; Benzamides; Benzoxazines; Bromine; Cannabinoid Receptor Modulators; Cannabinoids; Carbamates; Disease Models, Animal; Drug Combinations; Electroshock; Enzyme Inhibitors; Fear; Glutamates; Hippocampus; Magnesium; Male; Memory; Morpholines; Naphthalenes; Neuronal Plasticity; Piperidines; Pyrazoles; Rats, Sprague-Dawley; Receptors, Cannabinoid; Stress Disorders, Post-Traumatic | 2017 |
Blockade of alcohol escalation and "relapse" drinking by pharmacological FAAH inhibition in male and female C57BL/6J mice.
Topics: Alcohol Drinking; Alcoholism; Amidohydrolases; Animals; Benzamides; Carbamates; Endocannabinoids; Ethanol; Male; Mice; Mice, Inbred C57BL; Random Allocation; Receptor, Cannabinoid, CB1; Recurrence | 2017 |
Effect of footshock stress on place conditioning produced by Δ
Topics: Affect; Animals; Arousal; Avoidance Learning; Benzamides; Carbamates; Conditioning, Classical; Dose-Response Relationship, Drug; Dronabinol; Electroshock; Male; Rats; Rats, Sprague-Dawley; Reward; Stress, Psychological | 2017 |
Activation of Endocannabinoid Receptor 2 as a Mechanism of Propofol Pretreatment-Induced Cardioprotection against Ischemia-Reperfusion Injury in Rats.
Topics: Animals; Apoptosis; Arachidonic Acids; Benzamides; Carbamates; Cells, Cultured; Endocannabinoids; Indoles; Male; Malondialdehyde; Myocardial Reperfusion Injury; Myocytes, Cardiac; Pentobarbital; Peroxidase; Propofol; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Signal Transduction; Superoxide Dismutase | 2017 |
Cannabinoid receptor agonist WIN55,212-2 and fatty acid amide hydrolase inhibitor URB597 ameliorate neuroinflammatory responses in chronic cerebral hypoperfusion model by blocking NF-κB pathways.
Topics: Amidohydrolases; Animals; Anti-Inflammatory Agents; Benzamides; Benzoxazines; Cannabinoid Receptor Agonists; Carbamates; Cerebrovascular Disorders; Endocannabinoids; Hippocampus; Macrophage Activation; Male; Morpholines; Naphthalenes; Neuritis; NF-kappa B; Prefrontal Cortex; Rats; Rats, Sprague-Dawley; Signal Transduction; Transcription Factor RelA | 2017 |
Enhanced anandamide signaling reduces flight behavior elicited by an approaching robo-beetle.
Topics: Amidohydrolases; Animals; Anti-Anxiety Agents; Anxiety; Arachidonic Acids; Avoidance Learning; Behavior, Animal; Benzamides; Benzodioxoles; Cannabinoid Receptor Agonists; Carbamates; Diazepam; Endocannabinoids; Fear; Male; Mice, Inbred C57BL; Monoacylglycerol Lipases; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant | 2017 |
The FAAH inhibitor URB597 suppresses hippocampal maximal dentate afterdischarges and restores seizure-induced impairment of short and long-term synaptic plasticity.
Topics: Amidohydrolases; Animals; Benzamides; Cannabinoids; Carbamates; Dentate Gyrus; Long-Term Potentiation; Male; Neuronal Plasticity; Rats; Seizures; Synaptic Transmission | 2017 |
Fatty acid amide hydrolase inhibitor URB597 may protect against kainic acid-induced damage to hippocampal neurons: Dependence on the degree of injury.
Topics: Amidohydrolases; Animals; Benzamides; Carbamates; Cell Death; Cell Nucleus; Cell Survival; Disease Models, Animal; Endoplasmic Reticulum; Enzyme Inhibitors; Hippocampus; Kainic Acid; Microscopy, Electron; Mitochondria; Neurons; Neuroprotective Agents; Rats, Wistar; Severity of Illness Index; Status Epilepticus | 2017 |
Inhibition of fatty acid amide hydrolase in the central amygdala alleviates co-morbid expression of innate anxiety and excessive alcohol intake.
Topics: Alcoholism; Amidohydrolases; Analysis of Variance; Animals; Anxiety Disorders; Benzamides; Carbamates; Central Amygdaloid Nucleus; Central Nervous System Depressants; Conditioning, Operant; Enzyme Inhibitors; Ethanol; Male; Maze Learning; Microinjections; Rats, Inbred Strains; Rats, Wistar; Restraint, Physical; Self Administration; Stress, Psychological | 2018 |
The cannabinoid transporter inhibitor OMDM-2 reduces social interaction: Further evidence for transporter-mediated endocannabinoid release.
Topics: Amidohydrolases; Amygdala; Animals; Arachidonic Acids; Behavior, Animal; Benzamides; Benzodioxoles; Benzyl Compounds; Cannabinoid Receptor Modulators; Carbamates; Endocannabinoids; Male; Piperidines; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Social Behavior | 2018 |
Redox system and phospholipid metabolism in the kidney of hypertensive rats after FAAH inhibitor URB597 administration.
Topics: Amidohydrolases; Animals; Benzamides; Blood Pressure; Carbamates; Humans; Hypertension, Renal; Kidney; Oxidation-Reduction; Phospholipids; Rats; Rats, Inbred SHR; Reactive Oxygen Species; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2 | 2018 |
Enhancing Endocannabinoid Neurotransmission Augments The Efficacy of Extinction Training and Ameliorates Traumatic Stress-Induced Behavioral Alterations in Rats.
Topics: Amidohydrolases; Animals; Arachidonic Acids; Benzamides; Benzodioxoles; Benzoxazines; Cannabinoid Receptor Modulators; Carbamates; Disease Models, Animal; Electroshock; Endocannabinoids; Extinction, Psychological; Glycerides; Male; Morpholines; Naphthalenes; Piperidines; Psychotropic Drugs; Rats, Sprague-Dawley; Social Isolation; Stress Disorders, Post-Traumatic; Synaptic Transmission | 2018 |
Modulation of central endocannabinoid system results in gastric mucosal protection in the rat.
Topics: Analysis of Variance; Animals; Arachidonic Acids; Benzamides; Benzodioxoles; Calcitonin Gene-Related Peptide; Carbamates; Catalepsy; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Routes; Endocannabinoids; Ethanol; Gastric Mucosa; Gastrointestinal Motility; Hypothermia; Male; Piperidines; Rats; Rats, Wistar; Somatostatin; Stomach Diseases; Superoxide Dismutase | 2018 |
Cannabinoids prevent depressive-like symptoms and alterations in BDNF expression in a rat model of PTSD.
Topics: Amidohydrolases; Animals; Benzamides; Benzoxazines; Brain-Derived Neurotrophic Factor; Cannabinoid Receptor Agonists; Cannabinoids; Carbamates; Depression; Disease Models, Animal; Electroshock; Enzyme Inhibitors; Gene Expression; Hippocampus; Male; Morpholines; Naphthalenes; Prefrontal Cortex; Rats, Sprague-Dawley; Stress Disorders, Post-Traumatic | 2018 |
Chronic treatment with URB597 ameliorates post-stress symptoms in a rat model of PTSD.
Topics: Amidohydrolases; Animals; Arachidonic Acids; Basolateral Nuclear Complex; Benzamides; Benzoxazines; CA1 Region, Hippocampal; Cannabinoid Receptor Antagonists; Carbamates; Dose-Response Relationship, Drug; Electric Stimulation; Endocannabinoids; Extinction, Psychological; Glycerides; Male; Morpholines; Naphthalenes; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rats; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Reflex, Startle; Stress Disorders, Post-Traumatic | 2018 |
The Endocannabinoid System Affects Myocardial Glucose Metabolism in the DOCA-Salt Model of Hypertension.
Topics: Animals; Benzamides; Blood Glucose; Carbamates; Desoxycorticosterone Acetate; Glucose; Glucose Transporter Type 1; Glucose Transporter Type 4; Glycogen; Hypertension; Insulin; Ketone Oxidoreductases; Male; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Myocardium; Phosphorylation; Proto-Oncogene Proteins c-akt; Rats; Rats, Wistar | 2018 |
Examination of the effects of cannabinoid ligands on decision making in a rat gambling task.
Topics: Animals; Benzamides; Benzoxazines; Carbamates; Decision Making; Dronabinol; Endocannabinoids; Gambling; Impulsive Behavior; Ligands; Male; Morpholines; Naphthalenes; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Rimonabant; Task Performance and Analysis | 2018 |
The prefrontal cortical endocannabinoid system modulates fear-pain interactions in a subregion-specific manner.
Topics: Animals; Behavior, Animal; Benzamides; Cannabinoid Receptor Modulators; Carbamates; Conditioning, Psychological; Endocannabinoids; Fear; Pain; Pain Measurement; Piperidines; Prefrontal Cortex; Pyrazoles; Rats | 2019 |
Inhibition of Fatty Acid Amide Hydrolase Improves Depressive-Like Behaviors Independent of Its Peripheral Antinociceptive Effects in a Rat Model of Neuropathic Pain.
Topics: Amidohydrolases; Animals; Arachidonic Acids; Behavior, Animal; Benzamides; Carbamates; Depression; Disease Models, Animal; Endocannabinoids; Enzyme Inhibitors; Feeding Behavior; Glycerides; Hippocampus; Locomotion; Male; Neuralgia; Neurogenesis; Pain Threshold; Polyunsaturated Alkamides; Rats, Wistar; Receptor, Cannabinoid, CB1; Signal Transduction; Swimming | 2019 |
Sub-chronic treatment with cannabidiol but not with URB597 induced a mild antidepressant-like effect in diabetic rats.
Topics: Animals; Antidepressive Agents; Benzamides; Cannabidiol; Carbamates; Depression; Diabetes Mellitus, Experimental; Dose-Response Relationship, Drug; Male; Rats; Rats, Wistar; Swimming | 2018 |
FAAH inhibition attenuates TLR3-mediated hyperthermia, nociceptive- and anxiety-like behaviour in female rats.
Topics: Amidohydrolases; Animals; Anxiety; Benzamides; Carbamates; Central Nervous System Agents; Enzyme Inhibitors; Fever; Hypothalamus; Inflammation; Macrophages; Microglia; Nociceptive Pain; Random Allocation; Rats; Rats, Sprague-Dawley; Toll-Like Receptor 3 | 2018 |
Inhibition of excessive autophagy and mitophagy mediates neuroprotective effects of URB597 against chronic cerebral hypoperfusion.
Topics: Adenylate Kinase; Animals; Autophagosomes; Autophagy; Beclin-1; Benzamides; Brain Ischemia; Carbamates; Hippocampus; Lysosomes; Male; Membrane Fusion; Mitochondria; Mitophagy; Neurons; Neuroprotective Agents; Phosphorylation; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-bcl-2; Rats, Sprague-Dawley; Synapses; TOR Serine-Threonine Kinases | 2018 |
Role of endocannabinoids in the hippocampus and amygdala in emotional memory and plasticity.
Topics: Amidohydrolases; Amygdala; Animals; Benzamides; CA1 Region, Hippocampal; Carbamates; Electroshock; Emotions; Endocannabinoids; Extinction, Psychological; Fear; Hippocampus; Long-Term Potentiation; Male; Memory; Microinjections; Neuronal Plasticity; Rats; Rats, Sprague-Dawley | 2018 |
Adult Cellular Neuroadaptations Induced by Adolescent THC Exposure in Female Rats Are Rescued by Enhancing Anandamide Signaling.
Topics: Adaptation, Psychological; Animals; Arachidonic Acids; Benzamides; Carbamates; Dentate Gyrus; Depression; Dronabinol; Endocannabinoids; Female; Marijuana Abuse; Neurogenesis; Neuronal Plasticity; Polyunsaturated Alkamides; Prefrontal Cortex; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Sexual Maturation; Signal Transduction; Synapses; Tissue Culture Techniques | 2018 |
Pharmacological blockade of fatty acid amide hydrolase (FAAH) by URB597 improves memory and changes the phenotype of hippocampal microglia despite ethanol exposure.
Topics: Amidohydrolases; Animals; Arachidonic Acids; Benzamides; Carbamates; Chemokines; Cytokines; Dentate Gyrus; Endocannabinoids; Enzyme Inhibitors; Ethanol; Gene Expression; Glial Fibrillary Acidic Protein; Hippocampus; Male; Memory; Memory, Long-Term; Memory, Short-Term; Microglia; Nitric Oxide Synthase Type II; Phenotype; Polyunsaturated Alkamides; Rats, Wistar; Receptors, Chemokine | 2018 |
Hypertension and chronic inhibition of endocannabinoid degradation modify the endocannabinoid system and redox balance in rat heart and plasma.
Topics: Amidohydrolases; Animals; Arachidonic Acids; Benzamides; Carbamates; Desoxycorticosterone Acetate; Endocannabinoids; Glycerides; Heart; Hypertension; Male; Myocardium; Oxidation-Reduction; Oxidative Stress; Polyunsaturated Alkamides; Rats, Inbred SHR; Rats, Wistar; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2 | 2018 |
The Effect of Long-Term Administration of Fatty Acid Amide Hydrolase Inhibitor URB597 on Oxidative Metabolism in the Heart of Rats with Primary and Secondary Hypertension.
Topics: Amidohydrolases; Animals; Benzamides; Carbamates; Desoxycorticosterone Acetate; Disease Models, Animal; Gene Expression Regulation; Heart; Hypertension; Injections, Intraperitoneal; Male; NF-E2-Related Factor 2; Oxidative Stress; Rats; Xanthine Oxidase | 2018 |
Long-term administration of fatty acid amide hydrolase inhibitor (URB597) to rats with spontaneous hypertension disturbs liver redox balance and phospholipid metabolism.
Topics: Amidohydrolases; Animals; Benzamides; Carbamates; Endocannabinoids; Enzyme Inhibitors; Fatty Acids; Hypertension; Lipid Metabolism; Male; NF-kappa B; Oxidation-Reduction; Phospholipids; Rats; Reactive Oxygen Species; Tumor Necrosis Factor-alpha | 2019 |
Brain-Permeant and -Impermeant Inhibitors of Fatty Acid Amide Hydrolase Synergize with the Opioid Analgesic Morphine to Suppress Chemotherapy-Induced Neuropathic Nociception Without Enhancing Effects of Morphine on Gastrointestinal Transit.
Topics: Amidohydrolases; Analgesics, Opioid; Animals; Antineoplastic Agents; Arachidonic Acids; Benzamides; Brain; Cannabinoids; Carbamates; Gastrointestinal Transit; Hyperalgesia; Indoles; Mice; Mice, Inbred C57BL; Morphine; Morpholines; Neuralgia; Nociception; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2 | 2018 |
Endocannabinoid interactions in the regulation of acquisition of contextual conditioned fear.
Topics: Animals; Arachidonic Acids; Benzamides; Benzodioxoles; Brain; Carbamates; Central Nervous System Agents; Conditioning, Psychological; Endocannabinoids; Fear; Glycerides; Male; Motor Activity; Nociception; Piperidines; Polyunsaturated Alkamides; Random Allocation; Rats, Wistar | 2019 |
Inhibition of Monoacylglycerol Lipase Reduces the Reinstatement of Methamphetamine-Seeking and Anxiety-Like Behaviors in Methamphetamine Self-Administered Rats.
Topics: Amidohydrolases; Amphetamine-Related Disorders; Animals; Anti-Anxiety Agents; Anxiety; Behavior, Addictive; Behavior, Animal; Benzamides; Benzodioxoles; Cannabinoid Receptor Antagonists; Carbamates; Central Nervous System Stimulants; Male; Maze Learning; Methamphetamine; Monoacylglycerol Lipases; Piperidines; Rats; Rats, Wistar | 2019 |
Changes in physicochemical properties of kidney cells membrane as a consequence of hypertension and treatment of hypertensive rats with FAAH inhibitor.
Topics: Amidohydrolases; Animals; Benzamides; Carbamates; Cell Membrane; Chromatography, High Pressure Liquid; Desoxycorticosterone Acetate; Disease Models, Animal; Enzyme Inhibitors; Hypertension; Kidney; Lipid Peroxidation; Male; N-Acetylneuraminic Acid; Phospholipids; Rats; Rats, Inbred SHR; Rats, Wistar | 2019 |
Fatty acid amide hydrolase inhibitor (URB597) as a regulator of myocardial lipid metabolism in spontaneously hypertensive rats.
Topics: Amidohydrolases; Animals; Benzamides; Carbamates; Enzyme Inhibitors; Lipid Metabolism; Myocardium; Rats; Rats, Inbred SHR; Rats, Inbred WKY | 2019 |
Anandamide Reduces the Toxic Synergism Exerted by Quinolinic Acid and Glutaric Acid in Rat Brain Neuronal Cells.
Topics: Animals; Arachidonic Acids; Benzamides; Cannabinoid Receptor Agonists; Carbamates; Cell Survival; Cells, Cultured; Cerebral Cortex; Drug Synergism; Endocannabinoids; Female; Glutarates; Male; Neurons; Piperidines; Polyunsaturated Alkamides; Pregnancy; Pyrazoles; Quinolinic Acid; Rats; Rats, Inbred WF; Receptors, Cannabinoid | 2019 |
Hypothalamic endocannabinoid signalling modulates aversive responses related to panic attacks.
Topics: Animals; Arachidonic Acids; Benzamides; Biphenyl Compounds; Blood Pressure; Cannabinoids; Carbamates; Corticosterone; Dorsomedial Hypothalamic Nucleus; Endocannabinoids; Indoles; Male; Microinjections; N-Methylaspartate; Panic Disorder; Piperidines; Pyrazoles; Rats | 2019 |
Brain permeant and impermeant inhibitors of fatty-acid amide hydrolase suppress the development and maintenance of paclitaxel-induced neuropathic pain without producing tolerance or physical dependence in vivo and synergize with paclitaxel to reduce tumor
Topics: Amidohydrolases; Analgesics; Animals; Antineoplastic Agents; Benzamides; Benzoxazines; Brain; Cannabinoids; Carbamates; Cell Line, Tumor; Cell Survival; Drug Synergism; Drug Tolerance; HEK293 Cells; Humans; Hyperalgesia; Male; Mice; Mice, Inbred C57BL; Morpholines; Naphthalenes; Neuralgia; Paclitaxel; Substance-Related Disorders | 2019 |
Role of the endocannabinoid system in the dorsal hippocampus in the cardiovascular changes and delayed anxiety-like effect induced by acute restraint stress in rats.
Topics: Amidohydrolases; Animals; Anxiety; Arachidonic Acids; Arterial Pressure; Behavior, Animal; Benzamides; Cannabinoid Receptor Agonists; Cannabinoid Receptor Antagonists; Carbamates; Disease Models, Animal; Endocannabinoids; Heart Rate; Hippocampus; Male; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Restraint, Physical; Skin Temperature; Stress, Psychological | 2019 |
Effects of Fatty Acid Amide Hydrolase Inhibitors Acute Administration on the Positive and Cognitive Symptoms of Schizophrenia in Mice.
Topics: Amidohydrolases; Animals; Avoidance Learning; Benzamides; Benzodioxoles; Carbamates; Cognition; Dizocilpine Maleate; Enzyme Inhibitors; Injections; Male; Memory; Mice; Motor Activity; Piperidines; Schizophrenia | 2019 |
Anti-Inflammatory Effects by Pharmacological Inhibition or Knockdown of Fatty Acid Amide Hydrolase in BV2 Microglial Cells.
Topics: Amidohydrolases; Animals; Anti-Inflammatory Agents; Benzamides; Carbamates; Cell Line; Cyclooxygenase 2; Cytokines; Dinoprostone; Gene Knockdown Techniques; Inflammation; Microglia; Piperidines; Pyridines | 2019 |
Antinociceptive and antidepressive efficacies of the combined ineffective doses of S-ketamine and URB597.
Topics: Amidohydrolases; Analgesics; Animals; Antidepressive Agents; Behavior, Animal; Benzamides; Carbamates; Dose-Response Relationship, Drug; Drug Synergism; Ketamine; Male; Mice, Inbred Strains; Motor Activity; Nociceptive Pain; Receptors, N-Methyl-D-Aspartate; Swimming | 2019 |
Anandamide modulation of circadian- and stress-dependent effects on rat short-term memory.
Topics: Animals; Arachidonic Acids; Arousal; Benzamides; Carbamates; Circadian Rhythm; Corticosterone; Emotions; Endocannabinoids; Male; Memory, Short-Term; Polyunsaturated Alkamides; Rats; Rats, Sprague-Dawley; Stress, Psychological | 2019 |
URB597 ameliorates the deleterious effects induced by binge alcohol consumption in adolescent rats.
Topics: Aging; Amidohydrolases; Animals; Benzamides; Binge Drinking; Brain; Brain-Derived Neurotrophic Factor; Carbamates; Cytokines; Male; Rats; Rats, Wistar | 2019 |
Targeting the inhibition of fatty acid amide hydrolase ameliorate the endocannabinoid-mediated synaptic dysfunction in a valproic acid-induced rat model of Autism.
Topics: Amidohydrolases; Animals; Arachidonic Acids; Autism Spectrum Disorder; Benzamides; Carbamates; Disease Models, Animal; Endocannabinoids; Enzyme Inhibitors; Female; Long-Term Synaptic Depression; Neuronal Plasticity; Polyunsaturated Alkamides; Prefrontal Cortex; Pregnancy; Prenatal Exposure Delayed Effects; Protein Transport; Rats; Receptors, AMPA; Receptors, Metabotropic Glutamate; Social Behavior; Valproic Acid | 2020 |
Different Routes to Inhibit Fatty Acid Amide Hydrolase: Do All Roads Lead to the Same Place?
Topics: Amidohydrolases; Animals; Benzamides; Carbamates; Cerebellum; Endocannabinoids; Enzyme Inhibitors; Hippocampus; Liver; Male; Mice, Inbred C57BL; Pyridazines; Urea | 2019 |
Adaptive mechanisms following antidepressant drugs: Focus on serotonin 5-HT
Topics: Acetylcysteine; Animals; Antidepressive Agents; Autoradiography; Benzamides; Brain; Carbamates; Citalopram; Imipramine; Ketanserin; Male; Nucleus Accumbens; Rats; Rats, Wistar; Receptor, Serotonin, 5-HT2A; Thiazepines | 2019 |
Neuropeptide Y and cannabinoids interaction in the amygdala after exposure to shock and reminders model of PTSD.
Topics: Amygdala; Animals; Arachidonic Acids; Arousal; Basolateral Nuclear Complex; Behavior, Animal; Benzamides; Carbamates; Depression; Disease Models, Animal; Endocannabinoids; Extinction, Psychological; Neuropeptide Y; Polyunsaturated Alkamides; Rats; Receptor, Cannabinoid, CB1; Receptors, Neuropeptide Y; Reflex, Startle; Social Behavior; Stress Disorders, Post-Traumatic | 2020 |
FAAH inhibition as a preventive treatment for migraine: A pre-clinical study.
Topics: Amidohydrolases; Animals; Benzamides; Carbamates; Disease Models, Animal; Male; Migraine Disorders; Nitroglycerin; Rats; Rats, Sprague-Dawley; Trigeminal Caudal Nucleus; Vasodilator Agents | 2020 |
Cannabidiol increases the nociceptive threshold in a preclinical model of Parkinson's disease.
Topics: Amidohydrolases; Analgesics; Animals; Benzamides; Brain; Cannabidiol; Capsaicin; Carbamates; Celecoxib; Hyperalgesia; Male; Mice; Mice, Inbred C57BL; Morphine; Nociception; Oxidopamine; Pain; Parkinson Disease; Piperidines; Pyrazoles; Thienamycins | 2020 |
URB597 protects against NLRP3 inflammasome activation by inhibiting autophagy dysfunction in a rat model of chronic cerebral hypoperfusion.
Topics: Animals; Autophagy; Benzamides; Brain Ischemia; Carbamates; Disease Models, Animal; Hippocampus; Inflammasomes; Male; Neuroprotective Agents; NLR Family, Pyrin Domain-Containing 3 Protein; Random Allocation; Rats; Rats, Sprague-Dawley | 2019 |
Endocannabinoid degradation inhibitors ameliorate neuronal and synaptic alterations following traumatic brain injury.
Topics: Amidohydrolases; Animals; Benzamides; Benzodioxoles; Brain Injuries, Traumatic; Carbamates; Electrophysiological Phenomena; Endocannabinoids; Enzyme Inhibitors; Excitatory Postsynaptic Potentials; Machine Learning; Male; Monoacylglycerol Lipases; Piperazines; Piperidines; Pyramidal Cells; Rats; Rats, Wistar; Sensorimotor Cortex; Succinimides | 2020 |
Endocannabinoid modulating drugs improve anxiety but not the expression of conditioned fear in a rodent model of post-traumatic stress disorder.
Topics: Animals; Anxiety; Benzamides; Benzoxazines; Carbamates; Conditioning, Psychological; Disease Models, Animal; Endocannabinoids; Fear; Male; Morpholines; Naphthalenes; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Rodentia; Stress Disorders, Post-Traumatic | 2020 |
Effects of hypertension and FAAH inhibitor treatment of rats with primary and secondary hypertension considering the physicochemical properties of erythrocytes.
Topics: Amidohydrolases; Animals; Benzamides; Carbamates; Disease Models, Animal; Erythrocyte Membrane; Hypertension; Lipid Peroxidation; Male; N-Acetylneuraminic Acid; Oxidative Stress; Rats; Rats, Inbred SHR | 2020 |
The endocannabinoid hydrolase FAAH is an allosteric enzyme.
Topics: Allosteric Regulation; Allosteric Site; Amidohydrolases; Animals; Arachidonic Acids; Benzamides; Biocatalysis; Carbamates; Catalytic Domain; Drug Design; Endocannabinoids; Enzyme Assays; Humans; Hydrolysis; Kinetics; Molecular Dynamics Simulation; Mutation; Polyunsaturated Alkamides; Protein Subunits; Rats | 2020 |
The effects of fatty acid amide hydrolase and monoacylglycerol lipase inhibitor treatments on lipopolysaccharide-induced airway inflammation in mice.
Topics: Amidohydrolases; Animals; Arachidonic Acids; Benzamides; Benzodioxoles; Carbamates; Cytokines; Endocannabinoids; Glycerides; Inflammation; Lipopolysaccharides; Lung; Male; Mice; Monoacylglycerol Lipases; Piperidines; Pneumonia; Polyunsaturated Alkamides; Respiratory Hypersensitivity | 2020 |
The fatty acid amide hydrolase inhibitor URB597 modulates splenic catecholamines in chronically stressed female and male rats.
Topics: Amidohydrolases; Animals; Anti-Anxiety Agents; Anxiety; Benzamides; Carbamates; Catechol O-Methyltransferase; Catecholamine Plasma Membrane Transport Proteins; Catecholamines; Endocannabinoids; Female; Interleukin-10; Interleukin-6; Male; Monoamine Oxidase; Neuroprotective Agents; Open Field Test; Phenylethanolamine N-Methyltransferase; Rats, Wistar; Sex Factors; Spleen; Stress, Physiological | 2020 |
Visual High-Throughput Screening for Developing a Fatty Acid Amide Hydrolase Natural Inhibitor Based on an Enzyme-Activated Fluorescent Probe.
Topics: Amidohydrolases; Benzamides; Carbamates; Cell Line; Cell Survival; Fluorescent Dyes; High-Throughput Screening Assays; Humans; Isoxazoles; Psoralea; Recombinant Proteins | 2020 |
The FAAH Inhibitor URB597 Modulates Lipid Mediators in the Brain of Rats with Spontaneous Hypertension.
Topics: Animals; Arachidonic Acids; Benzamides; Brain; Carbamates; Disease Models, Animal; Endocannabinoids; Hypertension; Injections, Intraperitoneal; Male; Malondialdehyde; Oxidation-Reduction; Phospholipids; Polyunsaturated Alkamides; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Receptor, Cannabinoid, CB2; Receptors, Cannabinoid; Receptors, G-Protein-Coupled | 2020 |
Antidepressant-like effects of URB597 and JZL184 in male and female rats exposed to early life stress.
Topics: Age Factors; Animals; Antidepressive Agents; Benzamides; Benzodioxoles; Carbamates; Depression; Female; Male; Piperidines; Rats; Rats, Sprague-Dawley; Social Interaction; Stress, Psychological; Treatment Outcome | 2020 |
The fatty-acid amide hydrolase inhibitor URB597 inhibits MICA/B shedding.
Topics: Amidohydrolases; Benzamides; Carbamates; Cell Line, Tumor; Culture Media; Gene Expression Regulation, Neoplastic; Histocompatibility Antigens Class I; Humans; Neoplasms; NK Cell Lectin-Like Receptor Subfamily K; T-Lymphocytes, Cytotoxic; Tissue Inhibitor of Metalloproteinase-3 | 2020 |
Effects of systemic endocannabinoid manipulation on social and exploratory behavior in prairie voles (Microtus ochrogaster).
Topics: Animals; Anxiety; Arachidonic Acids; Arvicolinae; Behavior, Animal; Benzamides; Carbamates; Endocannabinoids; Exploratory Behavior; Female; Male; Maze Learning; Nucleus Accumbens; Pair Bond; Polyunsaturated Alkamides; Pyrazoles; Receptor, Cannabinoid, CB1; Receptors, Oxytocin; Social Behavior | 2021 |
Intravenous doxapram administration as a potential model of panic attacks in rats.
Topics: Administration, Intravenous; Alprazolam; Animals; Benzamides; Carbamates; Central Nervous System Stimulants; Disease Models, Animal; Doxapram; Male; Maze Learning; Panic Disorder; Periaqueductal Gray; Proto-Oncogene Proteins c-fos; Rats; Rats, Wistar | 2021 |
URB597 Prevents the Short-Term Excitotoxic Cell Damage in Rat Cortical Slices: Role of Cannabinoid 1 Receptors.
Topics: Amidohydrolases; Animals; Apoptosis; Benzamides; Carbamates; Cells, Cultured; Cerebral Cortex; Male; Mitochondria; Neuroprotective Agents; Oxidative Stress; Quinolinic Acid; Rats, Wistar; Receptor, Cannabinoid, CB1 | 2021 |
URB597 abrogates anxiogenic and depressive behaviors in the methamphetamine-withdrawal mice: Role of the cannabinoid receptor type 1, cannabinoid receptor type 2, and transient receptor potential vanilloid 1 channels.
Topics: Amidohydrolases; Animals; Anxiety; Behavior, Animal; Benzamides; Cannabinoid Receptor Antagonists; Carbamates; Central Nervous System Stimulants; Depression; Disease Models, Animal; Endocannabinoids; Male; Methamphetamine; Mice; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Substance Withdrawal Syndrome; TRPV Cation Channels | 2021 |
Anti-Inflammatory Effects of Fatty Acid Amide Hydrolase Inhibition in Monocytes/Macrophages from Alzheimer's Disease Patients.
Topics: Aged; Alzheimer Disease; Amidohydrolases; Benzamides; Carbamates; Female; Humans; Interleukin-6; Leukocytes, Mononuclear; Lipopolysaccharides; Macrophages; Male; Middle Aged; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Tumor Necrosis Factor-alpha | 2021 |
Beneficial Changes in Rat Vascular Endocannabinoid System in Primary Hypertension and under Treatment with Chronic Inhibition of Fatty Acid Amide Hydrolase by URB597.
Topics: Acetylcholine; Amidohydrolases; Animals; Aorta; Arachidonic Acids; Benzamides; Carbamates; Endocannabinoids; Essential Hypertension; Hypertension; Male; Mesenteric Arteries; Nitroprusside; Polyunsaturated Alkamides; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Receptors, Cannabinoid; Vasoconstriction; Vasodilation | 2021 |
Neuroprotective Effects of VEGF-A Nanofiber Membrane and FAAH Inhibitor URB597 Against Oxygen-Glucose Deprivation-Induced Ischemic Neuronal Injury.
Topics: Amidohydrolases; Animals; Apoptosis; Benzamides; Brain Ischemia; Carbamates; Cells, Cultured; Endocannabinoids; Glucose; Hippocampus; Membranes, Artificial; Nanofibers; Neurons; Neuroprotective Agents; Oxygen; Rats, Sprague-Dawley; Vascular Endothelial Growth Factor A | 2021 |
Kainate-Induced Degeneration of Hippocampal Neurons. Protective Effect of Activation of the Endocannabinoid System.
Topics: Animals; Arachidonic Acids; Autophagosomes; Benzamides; CA3 Region, Hippocampal; Carbamates; Dentate Gyrus; Endocannabinoids; Endoplasmic Reticulum; Excitatory Amino Acid Agonists; Golgi Apparatus; Kainic Acid; Lysosomes; Male; Microscopy, Electron; Necrosis; Nerve Degeneration; Polyunsaturated Alkamides; Pyramidal Cells; Rats; Rats, Wistar; Status Epilepticus | 2021 |
Fatty Acid Amide Hydrolase (FAAH) Inhibition Modulates Amyloid-Beta-Induced Microglia Polarization.
Topics: Alzheimer Disease; Amidohydrolases; Amyloid beta-Peptides; Animals; Arachidonic Acids; Benzamides; Carbamates; Cell Line; Cell Movement; Cell Polarity; Cytokines; Cytoskeleton; Disease Models, Animal; Endocannabinoids; Mice; Microglia; Polyunsaturated Alkamides | 2021 |
The effect of URB597, exercise or their combination on the performance of 6-OHDA mouse model of Parkinson disease in the elevated plus maze, tail suspension test and step-down task.
Topics: Animals; Behavior, Animal; Benzamides; Carbamates; Disease Models, Animal; Elevated Plus Maze Test; Hindlimb Suspension; Male; Mice; Mice, Inbred Strains; Oxidopamine; Parkinson Disease | 2021 |
Effects of Fatty Acid Amide Hydroxylase Inhibitor URB597 on the Catecholaminergic Activity of the Adrenal Medulla in Stressed Male and Female Rats.
Topics: Adrenal Medulla; Amidohydrolases; Animals; Benzamides; Carbamates; Catechol O-Methyltransferase; Catecholamines; Endocannabinoids; Female; Male; Monoamine Oxidase; Organ Size; Pain; Rats, Wistar; Stress, Psychological | 2022 |
Sex specific effects of the fatty acid amide hydrolase inhibitor URB597 on memory and brain β
Topics: Amidohydrolases; Animals; Benzamides; Brain; Carbamates; Female; Male; Memory; Rats; Rats, Wistar; Receptors, Adrenergic, beta; Receptors, Dopamine D1; Sex Characteristics; Stress, Psychological | 2022 |
Effect of Fatty Acid Amide Hydrolase Inhibitor URB597 on Orofacial Pain Perception in Rats.
Topics: Amidohydrolases; Animals; Benzamides; Calcitonin Gene-Related Peptide; Carbamates; Endocannabinoids; Facial Pain; Pain Perception; Polyunsaturated Alkamides; Rats; Receptor, Cannabinoid, CB1; Receptors, Cannabinoid; RNA, Messenger | 2022 |
URB597 and Andrographolide Improve Brain Microvascular Endothelial Cell Permeability and Apoptosis by Reducing Oxidative Stress and Inflammation Associated with Activation of Nrf2 Signaling in Oxygen-Glucose Deprivation.
Topics: Anti-Inflammatory Agents; Apoptosis; Benzamides; Brain; Carbamates; Diterpenes; Endothelial Cells; Glucose; Humans; Inflammation; NF-E2-Related Factor 2; Oxidative Stress; Oxygen; Permeability; Reactive Oxygen Species | 2022 |
Tonic Endocannabinoid Levels Modulate Retinal Signaling.
Topics: Animals; Benzamides; Cannabinoid Receptor Agonists; Carbamates; Endocannabinoids; Mice; Retina | 2022 |