carbamates and urb 597

carbamates has been researched along with urb 597 in 372 studies

Research

Studies (372)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's114 (30.65)29.6817
2010's229 (61.56)24.3611
2020's29 (7.80)2.80

Authors

AuthorsStudies
Bátkai, S; Bukoski, RD; Harvey-White, J; Kunos, G; Liu, J; Mackie, K; Offertáler, L; Osei-Hyiaman, D; Pacher, P; Radaeva, S; Rudd, MA1
Duranti, A; Fegley, D; Gaetani, S; Mor, M; Piomelli, D; Tarzia, G; Tontini, A1
Goldberg, SR; Makriyannis, A; Matthews, SA; Panlilio, LV; Solinas, M; Tanda, G1
Darmani, NA; Di Marzo, V; McClanahan, BA; Petrosino, S; Trinh, C; Valenti, M1
Bushell, KN; Clark, JD; Huang, N; Murphy, EA; Pan, N; Ramarao, MK; Shen, MW; Wang, Y; Williams, C1
Comelli, F; Costa, B; Fowler, CJ; Holt, S1
Lambert, DM; Okamoto, Y; Sun, YX; Tsuboi, K; Ueda, N; Zhao, LY1
Gessa, GL; Melis, M; Muntoni, AL; Perra, S; Pillolla, G; Pistis, M1
Bisogno, T; Cristino, L; de Novellis, V; Di Marzo, V; Guglielmotti, V; Maione, S; Palazzo, E; Petrosino, S; Rossi, F; Valenti, M1
Fegley, D; Gutierrez, T; Hohmann, AG; Piomelli, D; Suplita, RL1
Aslan, S; Greenwood, R; Jayamanne, A; Mitchell, VA; Piomelli, D; Vaughan, CW1
Bambico, FR; Bortolato, M; Campolongo, P; Cassano, T; Cuomo, V; Debonnel, G; Duranti, A; Gobbi, G; Goldberg, SR; Mangieri, R; Mor, M; Morgese, MG; Piomelli, D; Solinas, M; Tarzia, G; Tontini, A; Trezza, V1
Bolton, N; Connell, K; Hohmann, AG; Olsen, D; Piomelli, D1
Aguado, T; Cravatt, B; Galve-Roperh, I; Guzmán, M; Kokaia, Z; Lutz, B; Marsicano, G; Monory, K; Palazuelos, J; Stella, N1
Bermúdez-Silva, FJ; Hansson, AC; Heilig, M; Hyytiä, P; Kunos, G; Malinen, H; Rimondini, R; Rodriguez de Fonseca, F; Sanchez-Vera, I; Sommer, WH1
Jones, PG; Ramarao, MK; Rogers, KE; Uveges, A; Wang, Y; Xu, J1
Filip, M; McCreary, AC; Przegaliński, E; Zaniewska, M1
Goldberg, SR; Justinova, Z; Solinas, M; Tanda, G1
Brotchie, JM; Di Marzo, V; Lee, J1
Compton, TR; Dasse, O; Duranti, A; Monaghan, EP; Mor, M; Parrott, JA; Piomelli, D; Putman, D; Tarzia, G; Tontini, A1
Bandell, M; Cravatt, BF; McKinney, MK; Patapoutian, A; Saghatelian, A1
Alexander, JP; Cravatt, BF1
Duranti, A; Gatti, G; Kathuria, S; Lodola, A; Mor, M; Piersanti, G; Piomelli, D; Plazzi, PV; Rivara, S; Tarzia, G; Tontini, A1
Cichewicz, DL; Haller, VL; Welch, SP1
Clapper, JR; Duranti, A; Mor, M; Piomelli, D; Tarzia, G; Tontini, A1
Nomikos, GG; Panagis, G; Vlachou, S1
Fowler, CJ; Holt, S; Paylor, B1
Adriani, W; Canese, R; Laviola, G; Marco, EM; Podo, F; Viveros, MP1
Cross-Mellor, SK; Ossenkopp, KP; Parker, LA; Piomelli, D1
Barrett, DA; Chapman, V; Jhaveri, MD; Kendall, DA; Richardson, D1
Goldberg, SR; Justinova, Z; Makriyannis, A; Piomelli, D; Solinas, M; Tanda, G; Vadivel, SK; Wertheim, CE; Yasar, S1
Bhatia, P; Brioni, JD; Kolasa, T; Lannoye, GS; Patel, M; Richardson, P; Rogers, JC; Saraf, A; Stewart, A; Surowy, CS; Zhang, D; Zheng, GZ1
Ali, N; Chapman, V; Chimenti, M; de Lago, E; Fernandez-Ruiz, J; Kendall, DA; Millns, PJ; Ryland, E1
Ho, WS; Randall, MD1
Laitinen, JT; Lehtonen, M; Palomäki, VA; Savinainen, JR1
Hillard, CJ; Rademacher, DJ1
Lam, FF; Luk, PW; Ng, ES1
Ahn, K; Cravatt, BF; Lichtman, AH; Martin, BR; Naidu, PS; Varvel, SA1
Kreitzer, AC; Malenka, RC1
Chen, J; Faltynek, CR; Holzman, TF; Lake, MR; Moreland, RB; Neelands, T; Niforatos, W; Scott, VE; Walter, KA; Zhang, XF1
Alajakku, K; Fowler, CJ; Thors, L1
Drucker-Colin, R; Millán-Aldaco, D; Murillo-Rodríguez, E; Palomero-Rivero, M; Vázquez, E1
Trang, T1
Calignano, A; Compton, TR; Duranti, A; La Rana, G; Loverme, J; Mor, M; Parrott, J; Piomelli, D; Russo, R; Tarzia, G; Tontini, A1
Drysdale, AJ; Pertwee, RG; Platt, B; Ryan, D1
Arguello, O; Bortolato, M; Duranti, A; Fu, J; Kim, JH; Mangieri, RA; Mor, M; Piomelli, D; Tarzia, G; Tontini, A1
Luo, L; Tham, CS; Webb, M; Whitaker, J1
Agrò, AF; Bagetta, G; Bari, M; Cerulli, A; Corasaniti, MT; De Simone, C; Gasperi, V; Maccarrone, M; Morrone, LA; Nucci, C; Tartaglione, R; Terrinoni, A1
Castillo-Melendez, JA; Järvinen, T; Juvonen, RO; Kataja, AO; Koskinen, AM; Myllymäki, MJ; Nevalainen, T; Saario, SM1
Eriksson, J; Fowler, CJ; Thors, L1
Gorzalka, BB; Hill, MN; Morrish, AC1
Herradón, E; López-Miranda, V; Martín, MI1
Kaiser, N; Lutz, B; Monory, K; Moreira, FA1
Gorzalka, BB; Hill, MN; McLaughlin, RJ; Morrish, AC1
Artmann, A; Clausen, BH; Degn, M; Finsen, B; Hansen, HS; Hansen, SH; Lambertsen, KL; Lund, TM; Meldgaard, M; Petersen, G1
Gauthier, KM; Hammock, BD; Hillard, CJ; Ho, WS; Huang, H; Thompson, J; Wheelock, CE1
Cassano, T; Cuomo, V; Giuffrida, A; Morgese, MG1
Fratta, W; Goldberg, SR; Haller, J; Makriyannis, A; Medalie, J; Mikics, E; Piomelli, D; Scherma, M; Tanda, G; Vadivel, SK; Yasar, S1
Castiglioni, C; Di Marzo, V; Guidali, C; Maccarrone, M; Marras, E; Parolaro, D; Perletti, G; Petrosino, S; Realini, N; Rubino, T; Viganó, D1
Hungund, BL; Manzanares, J; Sanguino, E; Vinod, KY; Yalamanchili, R1
Ahn, K; Alexander, JP; Arendse, A; Cravatt, BF; Fitzgerald, LR; Johnson, DS; Liimatta, M; Lund, ET; Nomanbhoy, TK; Nugent, RA; Stevenson, T1
Limebeer, CL; Mechoulam, R; Parker, LA; Piomelli, D; Rock, EM1
Béquet, F; Desbazeille, M; Le Fur, G; Ludwiczak, P; Maftouh, M; Picard, C; Scatton, B; Uzabiaga, F1
Trezza, V; Vanderschuren, LJ2
Alizadeh, AM; Haghparast, A; Khani, A; Motamedi, F; Naderi, N; Rezaii, N; Saber-Tehrani, A1
Blankman, JL; Cravatt, BF; Simon, GM1
Finn, DP; Kelly, JP; O'Driscoll, M; Roche, M1
Bradshaw, HB; Burstein, S; Chen, JS; Cravatt, BF; Hu, SS; Hughes, HV; Jahnsen, JA; Masuda, K; McHugh, D; O'Dell, DK; Prieto, AL; Rimmerman, N; Thompson, EL; Vasko, MR; Vefring, E; Walker, JM1
Bilbao, A; Braconi, S; Cannella, N; Ciccocioppo, R; Cippitelli, A; Defonseca, FR; Duranti, A; Piomelli, D; Tontini, A1
Brand, S; Buckley, NE; Emmerdinger, D; Göke, B; Keenan, CM; Lutz, B; Massa, F; Patel, KD; Sharkey, KA; Sibaev, A; Storr, MA; Yüce, B; Zhang, H1
Alexander, SP; Barrett, DA; Bennett, AJ; Chapman, V; Garle, MJ; Jhaveri, MD; Kendall, DA; Patel, A; Richardson, D; Robinson, I; Sagar, DR; Sun, Y1
Njie, YF; Qiao, Z; Song, ZH; Wang, W; Xiao, Z1
Astarita, G; Eisenstein, SA; Hohmann, AG; Moise, AM; Piomelli, D1
Aziz Ahari, F; Motamedi, F; Naderi, N; Najarkolaei, AH; Shafaghi, B1
Cristino, L; Di Marzo, V; Drago, F; Leggio, GM; Micale, V; Petrosino, S; Tamburella, A1
Hasanein, P; Komaki, A; Mirazi, N; Shahidi, S1
Adamczyk, P; Filip, M; Gołda, A; McCreary, AC; Przegaliński, E1
Coomber, B; Mason, R; O'Donoghue, MF1
Fowler, CJ; Ghafouri, N1
Aguiar, DC; Guimarães, FS; Lisboa, SF; Resstel, LB1
Chapman, V; Kendall, DA; Sagar, DR1
Barnes, C; Fadda, P; Fattore, L; Fratta, W; Gamaleddin, I; Goldberg, SR; Haller, J; Justinová, Z; Le Foll, B; Medalie, J; Mikics, E; Panlilio, LV; Piomelli, D; Scherma, M; Stroik, J; Tanda, G; Yasar, S1
Haller, VL; Stevens, DL; Welch, SP1
Bortolato, M; Chefer, SI; Clapper, JR; Goldberg, SR; Justinova, Z; King, AR; Mangieri, RA; Mukhin, AG; Piomelli, D; Redhi, GH; Yasar, S1
Avraham, HK; Avraham, S; Koziel, H; Lu, TS; Makriyannis, A; Seng, S; Tachado, SD1
Butler, RK; Finn, DP; Gavin, AM; Lang, Y; Rea, K1
Billi, S; Farina, M; Franchi, AM; Gervasi, MG; Perez Martinez, S; Rapanelli, M; Ribeiro, ML1
Goldberg, SR; Luchicchi, A; Melis, M; Muntoni, AL; Pillolla, G; Pistis, M; Yasar, S1
Booker, L; Cravatt, BF; Lichtman, AH; Naidu, PS1
Adriani, W; Laviola, G; Marco, EM; Parolaro, D; Rubino, T; Viveros, MP1
Gardiner, SM; Ho, WS1
Bianchi, BR; Cavanaugh, EJ; Chen, J; Faltynek, CR; Kim, D; Kym, PR; Reilly, RM1
Boger, DL; Cravatt, BF; Lichtman, AH; Schlosburg, JE1
Kwiatkowska, M; Limebeer, CL; Litt, DL; Parker, LA; Piomelli, D; Rock, EM1
Barna, I; Barsvari, B; Goldberg, S; Gyimesi Pelczer, K; Haller, J; Panlilio, LV; Yasar, S1
Li, P; Longhurst, JC; Tjen-A-Looi, SC1
Kovacs, FE; Szabo, B; Urbanski, MJ1
Cadet, JL; Drago, F; Goldberg, SR; Mazzola, C; Medalie, J; Panlilio, LV; Scherma, M; Solinas, M; Tanda, G; Yasar, S1
Abdullah, RA; Carlson, BL; Cravatt, BF; Lichtman, AH; Long, JZ; Ramesh, D; Schlosburg, JE1
Benton, VM; Bradshaw, HB; Cravatt, BF; Hu, SS; Masuda, K; O'Dell, DK; Rimmerman, N; Stuart, JM; Walker, JM1
Käsnänen, H; Laitinen, JT; Leppänen, J; Minkkilä, A; Nevalainen, T; Poso, A; Saario, SM; Savinainen, JR; Xhaard, H1
Coen, KM; Forget, B; Le Foll, B1
Abdullah, RA; Boger, DL; Cravatt, BF; Kinsey, SG; Lichtman, AH; Long, JZ; O'Neal, ST; Poklis, JL1
Hasanein, P; Keshavarz, M; Parviz, M; Roohbakhsh, A1
Gontinou, C; Karaliota, S; Mavri-Vavayanni, M; Psarra, K; Siafaka-Kapadai, A1
Haghparast, A; Hosseini Najarkolaei, A; Motamedi, F; Naderi, N; Saber-Tehrani, A1
Eisenstein, SA; Hohmann, AG; Holmes, PV1
Advani, T; Cassano, T; Giuffrida, A; Hensler, JG; Seillier, A1
Hasanein, P; Keshavarz, S; Moghaddam, AH; Rezvani, ME; Roohbakhsh, A1
Cravatt, BF; Hillard, CJ; Liu, QS; Long, JZ; Pan, B; Sun, D; Wang, W1
Allen, CP; Lang, ST; Leri, F; Manwell, LA; Parker, LA; Satvat, E1
Floresco, SB; Gorzalka, BB; Hill, MN; Hillard, CJ; McLaughlin, RJ; Morrish, AC; Viau, V1
Fowler, CJ; Thors, L1
Anagnostopoulos, D; Gkini, E; Mavri-Vavayianni, M; Siafaka-Kapadai, A1
Adamczyk, P; Bienkowski, P; Filip, M; McCreary, AC; Mierzejewski, P; Przegalinski, E1
Galadari, S; Jaligam, V; Oz, M; Petroianu, G; Shippenberg, TS; Shuba, YM1
Bettoni, I; Comelli, F; Costa, B; Di Marzo, V; Giagnoni, G; Petrosino, S1
Burdet, B; De Laurentiis, A; Fernandez-Solari, J; Mohn, C; Rettori, V; Zorrilla Zubilete, MA1
Bernardi, G; Cantarella, C; Castelli, M; Cavasinni, F; Centonze, D; De Chiara, V; Mataluni, G; Musella, A; Rossi, S1
Baufreton, J; Manuel, I; Morera-Herreras, T; Rodriguez-Puertas, R; Ruiz-Ortega, JA; Taupignon, A; Ugedo, L1
Alger, BE; Kim, J1
Guindon, J; Hohmann, AG; Spradley, JM1
Bingham, B; Gorzalka, BB; Gray, JM; Hill, MN; Hillard, CJ; Lee, TT; McLaughlin, RJ; Shrestha, L; Viau, V1
Banke, TG; Chaplan, SR; Wickenden, AD1
Carta, S; Goldberg, SR; Lecca, S; Luchicchi, A; Muntoni, AL; Pillolla, G; Pistis, M; Yasar, S1
Benson, TE; Cravatt, BF; Kamtekar, S; Mileni, M; Stevens, RC; Wood, DC1
Bambico, FR; Cassano, T; Dominguez-Lopez, S; Gobbi, G; Katz, N; Piomelli, D; Walker, CD1
Alter, BJ; Burston, JJ; Cravatt, BF; Fowler, CJ; Gereau, RW; McKinney, MK; Pertwee, RG; Ross, RA; Thors, L; Wiley, JL1
De Bruyne, S; De Vos, F; Kapanda, CN; Labar, G; Lambert, DM; Muccioli, GG; Wyffels, L1
Limebeer, CL; McCallum, AL; Parker, LA1
Andrews, PL; Ho, WS; Percie du Sert, N; Rudd, JA1
De Chiaro, M; De Novellis, V; Gatta, L; Giordano, C; Guida, F; Krsiak, M; Luongo, L; Maione, S; Marabese, I; Migliozzi, AL; Palazzo, E; Siniscalco, D; Soukupová, M1
Anagnostopoulos, D; Evagorou, A; Farmaki, E; Siafaka-Kapadai, A1
Hacking, D; Kelly, RF; Lacerda, L; Lamont, KT; Lecour, S; Opie, LH; Somers, S; Thomas, P1
Bartolini, WP; Brotchie, JM; Fox, SH; Huot, P; Johnston, TH; Milne, GT; Pearson, JP; Sykes, KA; Wakefield, JD1
Casarotto, PC; Gomes, FV; Guimarães, FS; Resstel, LB1
Chambers, MG; Jassal, K; Johnson, MP; McDougall, JJ; Oskins, JL; Schuelert, N1
Bellini, G; Boccella, S; De Chiaro, M; de Novellis, V; Di Marzo, V; Gatta, L; Luongo, L; Maione, S; Marabese, I; Palazzo, E; Piscitelli, F; Rossi, F; Siniscalco, D; Vita, D1
Deadwyler, SA; Hampson, RE; Miller, F; Palchik, G1
Chapman, V; Lichtman, AH1
Giuffrida, A; Seillier, A2
McMahon, LR; Stewart, JL1
Arnold, JC; Hunt, GE; Long, LE; McGregor, IS; Sokolic, L1
Ahmad-Molaei, L; Aziz Ahari, F; Motamedi, F; Naderi, N1
Jain, NS; Manna, SS; Umathe, SN2
Berger, TW; Chan, RH; Deadwyler, SA; Goonawardena, AV; Hampson, RE; Marmarelis, VZ; Song, D; Sweatt, AJ1
Beltrame, JS; Burdet, J; Cella, M; Franchi, AM; Pardo, R; Ribeiro, ML; Sordelli, MS; Zotta, E1
Potschka, H; Soerensen, J; Wendt, H; Wotjak, CT1
Busquets-Garcia, A; de la Torre, R; Maldonado, R; Ozaita, A; Pastor, A; Puighermanal, E1
Cravatt, BF; Dudley, DT; Kinsey, SG; Lichtman, AH; Naidu, PS1
Alhamoruni, A; Larvin, M; O'Sullivan, SE; Wright, KL1
Hasanein, P; Shahidi, S1
Arias-Carrión, O; Drucker-Colín, R; Millán-Aldaco, D; Murillo-Rodríguez, E; Palomero-Rivero, M1
Butler, RK; Chapman, V; Doyle, KM; Finn, DP; Ford, GK; Hogan, M; Kelly, JP; Kendall, DA; Roche, M1
Ahmad-Molaei, L; Eslahkar, S; Mazar-Atabaki, A; Motiei-Langroudi, SM; Naderi, N; Ronaghi, A; Shirazi-zand, Z1
Burke, NN; Connor, TJ; Egan, LJ; Finn, DP; Ford, GK; Harhen, B; Kerr, DM; Roche, M1
Eriksen, GS; Gjerstad, J; Jacobsen, LM; Mahmood, A; Pedersen, LM1
Astarita, G; Caprioli, G; Ciccocioppo, R; Cippitelli, A; Duranti, A; Kallupi, M; Piomelli, D; Rodrìguez de Fonseca, F; Sagratini, G; Stopponi, S; Ubaldi, M1
Alves, FH; Corrêa, FM; Fedoce, AG; Ferreira-Junior, NC; Resstel, LB1
Baxter, P; Benfenati, F; Cerovic, M; Greco, B; Nazzaro, C; Parolaro, D; Pedarzani, P; Rubino, T; Tkatch, T; Tonini, R; Trusel, M1
Boczán, J; Czikora, Á; Daragó, A; Édes, I; Lizanecz, E; Papp, Z; Tóth, A1
Bambico, FR; Gobbi, G; Gorzalka, BB; Hill, MN; Hillard, CJ; McLaughlin, RJ; Stuhr, KL1
Centonze, D; Cutuli, D; De Chiara, V; Laricchiuta, D; Musella, A; Petrosini, L; Rossi, S1
Armirotti, A; Bandiera, T; Bertorelli, R; Colombano, G; Moreno-Sanz, G; Piomelli, D; Reggiani, A; Sasso, O; Scarpelli, R1
Bouzin, C; Feron, O; Gallez, B; Hamtiaux, L; Lambert, DM; Masquelier, J; Muccioli, GG1
Dunn, WR; Hopps, JJ; Randall, MD1
Dykstra, LA; Miller, LL; Picker, MJ; Schmidt, KT; Umberger, MD1
Blau, CW; Campbell, VA; Cowley, TR; Dempsey, CN; Finn, DP; Gowran, A; Lynch, MA; Murphy, N; Noonan, J; Olango, WM; Tanveer, R1
Harding-Rose, C; Khasabov, S; Khasabova, IA; Paz, J; Seybold, VS; Simone, DA1
Alexander, SP; Barrett, DA; Bennett, AJ; Burston, J; Chapman, V; Kendall, DA; Norris, LM; Okine, BN; Patel, A; Woodhams, S1
Cooper, TB; Hungund, BL; Psychoyos, D; Tejani-Butt, SM; Vinod, KY; Xie, S1
Baranowska-Kuczko, M; Kozłowska, H; MacLean, MR; Malinowska, B1
Currie, PJ; John, CS1
Araos, P; Calvo, EB; de Fonseca, FR; Galeano, P; Luque-Rojas, MJ; Santín, LJ; Suárez, J1
Abou-El-Ela, SH; El-Wakeil, AF; Zaitone, SA1
Canese, R; Ceci, C; Laviola, G; Macrì, S1
Bowie, AG; Campbell, VA; Gowran, A; Keating, SE; Noonan, J; Tanveer, R1
Bittles, V; Borazjani, A; Crow, JA; Potter, PM; Ross, MK1
Bosier, B; Lambert, DM; Muccioli, GG1
Bacigaluppi, M; Bari, M; Brambilla, E; Butti, E; Cambiaghi, M; Cebrian Silla, A; Centonze, D; Comi, G; D'Adamo, P; De Ceglia, R; De Chiara, V; Garcia-Verdugo, JM; Leocani, L; Maccarrone, M; Martino, G; Musella, A; Muzio, L; Quattrini, A; Rossi, S; Teneud, L1
Barker, E; Chester, JA; Cooper, BR; Davisson, VJ; Han, B; Kirchhoff, AM; Wright, R1
Campolongo, P; Cuomo, V; Damsteegt, R; Di Marzo, V; Manduca, A; Pasterkamp, RJ; Petrosino, S; Trezza, V; Van Kerkhof, LW; Vanderschuren, LJ; Zhou, Y1
Przewlocka, B; Starowicz, K1
Bradshaw, HB; Guindon, J; Hohmann, AG; Lai, Y; Takacs, SM1
Burger, F; Cravatt, B; Galan, K; Lenglet, S; Montecucco, F; Pelli, G; Soehnlein, O; Staub, C; Steffens, S; Thomas, A1
Avraham, HK; Li, H; Makriyannis, A; Seng, S; Vadivel, SK; Whitten, KM; Wood, JT1
de Oliveira, AC; Medeiros, DC; Moraes, MF; Moreira, FA; Rezende, GH; Vilela, LR1
Al-Banna, NA; Kelly, ME; Kianian, M; Lehmann, C1
Capoferri, L; Lodola, A; Mor, M; Mulholland, A; Piomelli, D; Rivara, S; Tarzia, G1
Banni, S; Cadeddu, F; Carta, G; Castelli, MP; De Montis, MG; Ennas, MG; Fadda, P; Fattore, L; Fratta, W; Frau, R; Lecca, S; Luchicchi, A; Madeddu, C; Melis, M; Pistis, M; Scheggi, S; Schilstrom, B1
Giuffrida, A; Martinez, AA; Seillier, A1
Cristino, L; De Petrocellis, L; Di Marzo, V; Korostynski, M; Makuch, W; Malek, N; Petrosino, S; Przewlocka, B; Slezak, M; Starowicz, K; Zychowska, M1
Bradshaw, HB; Cairns, EA; Di Polo, A; Kelly, ME; Slusar, JE; Szczesniak, AM1
Burlakova, N; Coicou, L; Harding-Rose, C; Holman, M; Khasabova, IA; Morse, T; Seybold, VS; Simone, DA1
Aguiar, DC; Gobira, PH; Moreira, FA1
Aliczki, M; Goldberg, SR; Haller, J; Panlilio, LV; Pelczer, KG1
Antunes-Rodrigues, J; Elias, LL; Ruginsk, SG; Uchoa, ET1
Centonze, D; Laricchiuta, D; Petrosini, L1
Aliczki, M; Balogh, Z; Haller, J; Kantor, S; Pelczer, KG; Spitzer, K1
Bindila, L; Fleischmann, BK; Lerner, R; Lutz, B; Matthey, M; Wenzel, D; Zimmer, A1
Cinar, R; Godlewski, G; Jourdan, T; Kunos, G; Lin, Y; Liu, J; Ntambi, JM; Xiong, K1
Cruz, JS; De Carvalho, CR; Pamplona, FA; Takahashi, RN1
Becker, A; Hoyer, FF; Kebschull, M; Khoury, M; Lerner, R; Lütjohann, D; Lutz, B; Nickenig, G; Schott, H; Slomka, H; Wojtalla, A; Zimmer, A1
Ceci, C; Laviola, G; Macrì, S; Marco, EM; Mela, V; Viveros, MP1
Anderson, WB; Gould, MJ; Mitchell, VA; Torres, RD; Vaughan, CW1
Abdullah, RA; Kwilasz, AJ; Lichtman, AH; Negus, SS; Poklis, JL1
Basavarajappa, BS; Nagre, NN; Subbanna, S; Xie, S1
Bystrowska, B; Filip, M; Gawliński, D; Pomierny, B; Smaga, I; Stankowicz, P1
Al Kury, LT; Ali, RM; Galadari, S; Howarth, FC; Oz, M; Rajesh, M; Shuba, YM; Thayyullathil, FT; Yang, KH1
Chavant, F; Duranti, A; Francheteau, M; Gennequin, B; Maccarrone, M; Makriyannis, A; Nader, J; Rapino, C; Solinas, M; Thiriet, N1
Andrews, MJ; Bradshaw, H; Czyzyk, T; Haskins, C; Jew, CP; Leishman, E; Lu, HC; Mackie, K; Morgan, D; Spencer, CM; Wu, CS1
Cravatt, BF; Germano, P; Hama, AT; Milne, GT; Pearson, JP; Sagen, J; Varghese, MS1
Everitt, BJ; Milton, AL; Ratano, P1
Gunduz, O; Tosun, NC; Ulugol, A1
Campolongo, P; Cuomo, V; Manduca, A; Palmery, M; Servadio, M; Trabace, L; Trezza, V; Vanderschuren, LJ1
Bader, M; Brosnihan, KB; Dechend, R; Howlett, AC; McGee, CM; Pulgar, VM; Varagic, J; Yamaleyeva, LM1
Hooker, JM; Liang, SH; Rotstein, BH; Shoup, TM; Vasdev, N; Wey, HY; Wilson, AA1
Drew, GM; Lau, BK; Mitchell, VA; Vaughan, CW1
Bindila, L; Hoheisel, U; Lerner, R; Lomazzo, E; Lutz, B; Remmers, F; Schwitter, C1
Altieri, F; Bedse, G; Cassano, T; Cifani, C; Colangeli, R; Gaetani, S; Lavecchia, AM; Romano, A1
Bernal-Chico, A; Canedo, M; Manterola, A; Mato, S; Matute, C; Pérez-Samartín, A; Rodríguez-Puertas, R; Victoria Sánchez-Gómez, M1
Impastato, RA; Katz, PS; Molina, PE; Rogers, EK; Sulzer, JK; Teng, SX1
Bowers, ME; Ressler, KJ1
Finn, DP; Henry, RJ; Kerr, DM; Roche, M1
Krustev, E; McDougall, JJ; Reid, A1
Aguiar, DC; Hott, SC; Moreira, FA; Resstel, LB; Viana, TG1
Fujinaga, M; Hatori, A; Kawamura, K; Kumata, K; Maeda, J; Nagai, Y; Ogawa, M; Shimoda, Y; Xie, L; Yamasaki, T; Yui, J; Zhang, MR1
de Ceballos, ML; Giusto, NM; Martín-Moreno, AM; Pascual, AC; Pasquaré, SJ1
Jergova, S; Nasirinezhad, F; Pearson, JP; Sagen, J1
Atsak, P; Campolongo, P; Cuomo, V; Hauer, D; McGaugh, JL; Morena, M; Peloso, A; Ratano, P; Roozendaal, B; Schelling, G; Trabace, L; Trezza, V1
Khasabova, IA; Simone, DA; Uhelski, ML1
Ceci, C; Laviola, G; Macrì, S; Proietti Onori, M1
Chauvet, C; Duranti, A; Lardeux, MV; Nicolas, C; Solinas, M; Thiriet, N1
Aguilar, DD; Chen, L; Lodge, DJ1
Bedse, G; Bellomo, A; Cassano, T; Cifani, C; Duranti, A; Gaetani, S; Lavecchia, MA; Micioni Di Bonaventura, MV; Pace, L; Romano, A; Tempesta, B1
Borges, AA; Fassini, A; Guimarães, FS; Lisboa, SF; Nejo, P; Resstel, LB1
Bastos, JR; Batista, LA; Moreira, FA1
Camargo, LH; Cunha, FQ; Gomes, FV; Guimarães, FS; Joca, SR; Lisboa, SF; Resstel, LB; Silva, AL; Uliana, DL1
Hasanein, P; Teimuri Far, M1
Binkowski, M; Czaja, M; Di Marzo, V; Kolosowska, N; Makuch, W; Malek, N; Morera, E; Mrugala, M; Przewlocka, B; Starowicz, K1
Armirotti, A; Auber, A; Bandiera, T; Barnes, C; Bertorelli, R; Chefer, SI; Goldberg, SR; Justinova, Z; Mascia, P; Moreno-Sanz, G; Panlilio, LV; Piomelli, D; Redhi, GH; Secci, ME; Yasar, S1
Aliev, R; Kitchigina, V; Shubina, L1
Hai, J; Lin, Q; Su, SH; Wu, YF; Yu, F1
Markert, A; Nozaki, C; Zimmer, A1
Grzęda, E; Malinowska, B; Schlicker, E; Toczek, M1
Aguiar, DC; de Oliveira, AC; Doria, JG; Ferreira-Vieira, TH; Gobira, PH; Massessini, AR; Medeiros, DC; Moraes, MF; Moreira, FA; Pereira, GS; Ribeiro, FM; Rodrigues, F; Viana, TG; Vilela, LR1
Del-Bel, EA; Gomes, FV; Guimarães, FS; Issy, AC; Pedrazzi, JF1
Krych, L; Moulton, K; Qin, M; Smith, CB; Xia, Z; Zeidler, Z1
Chmelova, M; Csanova, A; Danevova, V; Hlavacova, N; Jezova, D1
Hinz, B; Ivanov, I; Peters, K; Ramer, R; Salamon, A; Wollank, Y1
Ghafari-Vahed, M; Hasanein, P1
Cohen, A; Cravatt, BF; Grove, K; Limebeer, CL; Niphakis, MJ; Parker, LA; Rock, EM; Ward, JM1
Kregiel, J; Malek, N; Popik, P; Rygula, R; Starowicz, K1
Adamson Barnes, NS; Kazantzis, NP; Mitchell, VA; Vaughan, CW1
Congiu, C; Deplano, A; Fowler, CJ; Fredriksson Sundbom, M; Gouveia-Figueira, S; Hashemian, S; Karlsson, J; Onnis, V; Svensson, M1
Campolongo, P; De Castro, V; Gray, JM; Hill, MN; Morena, M; Palmery, M; Roozendaal, B; Trezza, V1
Cox, CD; Gall, CM; Geschwind, DH; Karsten, CA; Lee, D; Peñagarikano, O; Piomelli, D; Wei, D1
Collier, TL; Fujinaga, M; Hatori, A; Kumata, K; Liang, SH; Mori, W; Ran, C; Rotstein, BH; Shimoda, Y; Vasdev, N; Wang, L; Wang, Q; Yamasaki, T; Yui, J; Zhang, MR; Zhang, Y1
Aguilar, DD; Giuffrida, A; Lodge, DJ1
Gray, JM; Hill, MN; McLaughlin, RJ; Verlezza, S; Walker, CD1
Bandiera, T; Castellani, B; Dalvit, C; Garau, G; Giacomina, F; Lambruschini, C; Ottonello, G; Piomelli, D; Romeo, E; Scarpelli, R; Veronesi, M1
Fujinaga, M; Hatori, A; Ishii, H; Kumata, K; Kurihara, Y; Nengaki, N; Shimoda, Y; Xie, L; Yamasaki, T; Yui, J; Zhang, MR; Zhang, Y1
Bambico, FR; Duranti, A; Gobbi, G; Nobrega, JN1
Goldberg, SR; Justinova, Z; Makriyannis, A; Redhi, GH; Scherma, M; Schindler, CW; Vadivel, SK1
Aliczki, M; Baranyi, M; Barna, I; Goldberg, SR; Haller, J; Sperlagh, B; Till, I1
Alapafuja, SO; Bergman, J; Kangas, BD; Leonard, MZ; Makriyannis, A; Nikas, SP; Shukla, VG1
Forget, B; Gamaleddin, I; Goldberg, SR; Guranda, M; Le Foll, B1
Baranowska-Kuczko, M; Grzęda, E; Malinowska, B; Pędzińska-Betiuk, A; Toczek, M; Weresa, J1
Akirav, I; Zer-Aviv, TM1
Dithmer, S; Hinz, B; Ivanov, I; Merkord, J; Ramer, R; Winkler, K1
Cortesi, R; Drechsler, M; Esposito, E; Nastruzzi, C1
Baranowska-Kuczko, M; Harasim, E; Karpińska, O; Kasacka, I; Kloza, M; Kozłowska, H; Malinowska, B; Toczek, M1
Bielawska, K; Biernacki, M; Gęgotek, A; Skrzydlewska, E; Toczek, M; Łuczaj, W1
Giuffrida, A; Matricon, J; Seillier, A1
Freitas-Lima, LC; Meyrelles, SS; Nakamura-Palacios, EM; Pelição, R; Rodrigues, LC; Santos, MC; Vasquez, EC1
Aymerich, MS; Celorrio, M; Echeverry-Alzate, V; Fernández-Suárez, D; Franco, R; Hillard, CJ; López-Moreno, JA; Maldonado, R; Oyarzábal, J; Ramírez, MJ; Rojo-Bustamante, E1
Hai, J; Lin, Q; Su, SH; Wang, DP; Wang, YQ; Wu, YF1
Benini, R; Costa-Ferreira, W; Crestani, CC; Gomes-de-Souza, L; Oliveira, LA; Rodella, P1
Alves-Silva, J; Batista, EM; Doria, JG; Ferguson, SS; Ferreira-Vieira, TH; Moreira, FA; Ribeiro, FM1
Campolongo, P; Gray, JM; Hill, MN; Leitl, KD; Morena, M; Vecchiarelli, HA1
Cador, M; Caillé, S; Rubino, T; Simonnet, A; Zamberletti, E1
Abassi, L; Jelinek, R; König, F; Lomazzo, E; Lutz, B1
Batista, LA; Haibara, AS; Moreira, FA; Schenberg, LC1
Hai, J; Lin, Q; Liu, K; Su, S; Wang, D; Wu, Y1
Colín-González, AL; Escamilla-Ramírez, A; Galván-Arzate, S; García, E; Palencia-Hernández, G; Santamaría, A; Sotelo, J; Túnez, I1
Castañeda-Achutiguí, F; Escalante-Castañeda, A; Flores-Soto, ME; Gonzalez-Castañeda, RE; Tejeda-Martínez, AR; Viveros-Paredes, JM1
Benítez-Valenzuela, J; Colín-González, AL; de Jesús Negrete-Ruíz, M; Martínez-Sánchez, JE; Maya-López, M; Parra-Cid, C; Rangel-López, E; Ruiz-Contreras, HA; Sánchez-Chapul, L; Santamaría, A; Villeda-Hernández, J1
Duan, T; Fang, Y; Gu, N; Han, J; Shen, Y; Wang, F; Wang, Y; Zhang, X; Zhu, J1
Barrett, DA; Couch, DG; Karwad, MA; Larvin, M; Lund, JN; O'Sullivan, SE; Sarmad, S; Theophilidou, E; Wright, KL1
Baranowska-Kuczko, M; Harasim-Symbor, E; Kasacka, I; Malinowska, B; Pędzińska-Betiuk, A; Toczek, M; Weresa, J1
Hai, J; Kasper, G; Lin, Q; Liu, KJ; Wang, DP1
Campolongo, P; Carducci, F; Cortesi, R; Drechsler, M; Esposito, E; Mariani, P; Melancia, F; Nastruzzi, C; Ratano, P; Servadio, M; Trezza, V1
Krustev, E; McDougall, JJ; Muley, MM; Philpott, HT; Reid, A1
Gupta, K; Simone, DA; Uhelski, ML1
Chabowski, A; Harasim-Symbor, E; Kasacka, I; Malinowska, B; Pędzińska-Betiuk, A; Polak, A; Weresa, J1
Aisenberg, N; Akirav, I; Sabban, EL; Serova, L1
Abush, H; Akirav, I; Mizrachi Zer-Aviv, T; Segev, A; Shoshan, N1
Giza, J; Gross, SS; Kreek, MJ; Lee, FS; Schwartz, BI; Zhou, Y1
DeVuono, MV; Hrelja, KM; MacPherson, DV; Parker, LA; Wills, KL1
Fu, HL; Lu, Y; Sun, HJ; Wang, HW; Wang, SR; Xu, WY; Yang, F; Yao, XY; Yuan, HB; Zhang, H1
Hai, J; Lin, Q; Su, SH; Wu, YF1
Genewsky, A; Heinz, DE; Wotjak, CT1
Benigno, A; Butini, S; Campiani, G; Colangeli, R; Di Giovanni, G; Pierucci, M1
Kitchigina, VF; Matveeva, N; Mikheeva, IB; Pavlik, LL; Shubina, L1
Borruto, AM; Cannella, N; Ciccocioppo, R; Domi, A; Fotio, Y; Natividad, L; Roberto, M; Stopponi, S1
Ambrożewicz, E; Bielawska, K; Biernacki, M; Gęgotek, A; Skrzydlewska, E; Toczek, M1
Berardi, A; Campolongo, P; Colucci, P; Hill, MN; Morena, M; Palmery, M; Trezza, V1
Fehér, Á; Gyertyán, I; Gyires, K; Németh, J; Tóth, VE; Zádori, ZS1
Akirav, I; Burstein, O; Doron, R; Shoshan, N1
Akirav, I; Fidelman, S; Hillard, CJ; Lange, R; Mizrachi Zer-Aviv, T1
Chabowski, A; Harasim-Symbor, E; Kasacka, I; Lewandowska, A; Malinowska, B; Polak, A1
Carr, MR; Ferland, JN; Hoogeland, ME; Lee, AM; Pattij, T; Winstanley, CA1
Corcoran, L; Finn, DP; McGowan, F; Rea, K; Roche, M1
Gong, DY; Hai, KR; Jiang, HX; Ke, BW; Liu, J; Ma, G; Yang, Z; Zhou, C1
Chaves, YC; Crippa, JA; da Cunha, JM; de Morais, H; Genaro, K; Jesus, CHA; Waltrick, APF; Zanoveli, JM1
Finn, DP; Flannery, LE; Kerr, DM; Roche, M1
Hai, J; Su, SH; Wang, DP; Wu, YF1
Abush, H; Akirav, I; Hillard, CJ; Korem, N; Lange, R; Mizrachi Zer-Aviv, T; Sauber, G; Segev, A1
Cuccurazzu, B; Grilli, M; Nazzaro, C; Parolaro, D; Prini, P; Rubino, T; Tonini, R; Trusel, M; Zamberletti, E1
Blanco, E; Fernández-Arjona, MDM; Grondona, JM; López-Ávalos, MD; Pavón, FJ; Rivera, P; Rodríguez de Fonseca, F; Serrano, A; Silva-Peña, D; Suárez, J; Vargas, A1
Biernacki, M; Jastrząb, A; Malinowska, B; Remiszewski, P; Skrzydlewska, E; Timoszuk, M; Toczek, M1
Ambrożewicz, E; Biernacki, M; Jarocka-Karpowicz, I; Skrzydlewska, E; Toczek, M; Łuczaj, W1
Ambrożewicz, E; Biernacki, M; Gęgotek, A; Skrzydlewska, E; Toczek, M1
Hohmann, AG; Iyer, V; Makriyannis, A; Saberi, SA; Slivicki, RA; Vemuri, VK1
Aliczki, M; Balogh, Z; Biro, L; Haller, J; Szente, L; Varga, ZK1
Fukumori, R; Nawata, Y; Yamaguchi, T; Yamamoto, T1
Dobrzyńska, I; Figaszewski, ZA; Skrzydlewska, E; Szachowicz-Petelska, B; Weresa, J1
Chabowski, A; Harasim-Symbor, E; Kasacka, I; Lewandowska, A; Malinowska, B; Pędzińska-Betiuk, A; Polak, A; Weresa, J1
Aguilera-Portillo, G; Colonnello, A; Galván-Arzate, S; Kotlar, I; Pedraza-Chaverri, J; Rangel-López, E; Santamaría, A; Serratos, IN; Túnez, I; Wajner, M1
Aguiar, DC; Bastos, JR; Coimbra, CC; Costa, RB; Hott, SC; Mansur, FS; Moreira, FA; Resstel, LB; Viana, TG1
Hohmann, AG; Mali, SS; Slivicki, RA; Xu, Z1
Correa, FM; Fassini, A; Guimarães, FS; Hartmann, A; Lisboa, SF; Resstel, LB; Scopinho, A1
Banaszkiewicz, I; Biala, G; Kruk-Slomka, M; Slomka, T1
Sackett, S; Tanaka, M; Yagyu, K; Zhang, Y1
Ebrahimi-Ghiri, M; Khakpai, F; Shahini, F; Zarrindast, MR1
Campolongo, P; Colucci, P; Hill, MN; Mancini, GF; Morena, M; Palmery, M; Puglisi-Allegra, S; Santori, A; Trezza, V1
Bellozi, PMQ; Campos, AC; de Oliveira, ACP; Lima, IVA; Nakamura-Palacios, EM; Pelição, R; Rodrigues, LCM; Saliba, SW; Santos, MC; Teixeira, AL; Vieira, ÉLM1
Chen, PS; Chu, MC; Lee, CW; Lin, HC; Lu, TY; Wu, HF1
Bisogno, T; Coccurello, R; Giacovazzo, G; Maccarrone, M; Oddi, S; Piscitelli, F; Verde, R1
Faron-Górecka, A; Filip, M; Gawlińska, K; Gawliński, D; Smaga, I; Zaniewska, M1
Akirav, I; Maymon, N; Mizrachi Zer-Aviv, T; Sabban, EL1
Demartini, C; Greco, R; Misto, A; Piomelli, D; Reggiani, A; Tassorelli, C; Tumelero, E; Zanaboni, AM1
Bortolanza, M; Crivelaro do Nascimento, G; Del Bel, EA; Ferrari, DP; Ferreira-Junior, NC; Guimaraes, FS1
Hai, J; Lin, Q; Su, SH; Wang, DP; Wu, YF1
Cancienne, HL; Edwards, S; Fucich, EA; Gilpin, NW; Middleton, JW; Molina, PE; Stielper, ZF1
Diwan, M; Giacobbe, P; Gidyk, DC; Gouveia, FV; Hamani, C; Lipsman, N; Nobrega, JN; Vimalanathan, A1
Dobrzyńska, I; Figaszewski, ZA; Pędzińska-Betiuk, A; Skrzydlewska, E; Szachowicz-Petelska, B1
Angelucci, CB; Ballone, A; Dainese, E; De Fabritiis, G; Dufrusine, B; Fezza, F; Maccarrone, M; Oddi, S; Sabatucci, A; Simonetti, M1
Abohalaka, R; Bozkurt, TE; Nemutlu, E; Onder, SC; Sahin-Erdemli, I1
Dronjak, S; Ferizovic, H; Jankovic, M; Spasojevic, N; Stefanovic, B3
Cui, J; Feng, L; James, TD; Li, L; Liu, T; Ma, X; Shao, B; Tian, X; Yao, D1
Baranowska-Kuczko, M; Biernacki, M; Niklińska, GN; Skrzydlewska, E1
Adelman, J; Akirav, I; Alteba, S; Ben David, G; Doron, R; Hillard, CJ; Mizrachi Zer-Aviv, T; Tenenhaus, A1
Funato, K; Koike, K; Miyakawa, Y; Otsuka, M; Seimiya, T; Sekiba, K; Tanaka, E1
Bales, KL; Simmons, TC; Singh, ALK1
Batista, LA; Brianis, RC; Haibara, AS; Lopes, JB; Moreira, FA1
Aschner, M; Chavira-Ramos, K; Colín-González, AL; Karasu, Ç; Orozco-Morales, M; Santamaría, A; Tinkov, AA1
Ebrahimi-Ghiri, M; Khakpai, F; Zarrindast, MR1
Arosio, B; Chiurchiù, V; Maccarrone, M; Mari, D; Oddi, S; Scipioni, L1
Baranowska-Kuczko, M; Biernacki, M; Harasim-Symbor, E; Kasacka, I; Kloza, M; Kozłowska, H; Malinowska, B1
Hai, J; Jin, KY; Kang, K; Lin, Q; Wang, DP; Zhao, P1
Gordon, RY; Khutsian, SS; Kitchigina, VF; Mikheeva, IB; Shubina, LV1
Armeli, F; Bisogno, T; Businaro, R; Coccurello, R; D'Erme, M; De Caris, MG; Grieco, M; Maccarrone, M; Maggi, E; Mancini, P1
Ebrahimi-Ghiri, M; Shahini, F; Zarrindast, MR1
Jerczynska, H; Stasiolek, M; Szemraj, J; Wysiadecki, G; Zubrzycka, M; Zubrzycki, M1
Hai, J; Kang, K; Lin, Q; Lv, QL; Sun, J; Wang, DP1
Huang, JY; Protti, DA; Yates, CF1

Reviews

3 review(s) available for carbamates and urb 597

ArticleYear
Pharmacological profile of the selective FAAH inhibitor KDS-4103 (URB597).
    CNS drug reviews, 2006,Spring, Volume: 12, Issue:1

    Topics: Amidohydrolases; Analgesics; Animals; Anxiety; Benzamides; Brain; Cannabinoids; Carbamates; Depression; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Inhibitors; Humans; Neurons; Pharmacokinetics

2006
Inhibition of fatty acid amide hydrolase: a potential treatment for neuropathic pain.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2007, Mar-28, Volume: 27, Issue:13

    Topics: Amidohydrolases; Animals; Benzamides; Carbamates; Mice; Neuralgia; Rats

2007
Modulation of neuropathic-pain-related behaviour by the spinal endocannabinoid/endovanilloid system.
    Philosophical transactions of the Royal Society of London. Series B, Biological sciences, 2012, Dec-05, Volume: 367, Issue:1607

    Topics: Amides; Amidohydrolases; Animals; Arachidonic Acid; Arachidonic Acids; Behavior; Benzamides; Carbamates; Endocannabinoids; Enzyme Inhibitors; Ethanolamines; Glycerides; Humans; Microglia; Neuralgia; Palmitic Acids; Peripheral Nerve Injuries; Polyunsaturated Alkamides; Receptor, Cannabinoid, CB1; Spinal Cord Injuries; TRPV Cation Channels

2012

Other Studies

369 other study(ies) available for carbamates and urb 597

ArticleYear
Endocannabinoids acting at cannabinoid-1 receptors regulate cardiovascular function in hypertension.
    Circulation, 2004, Oct-05, Volume: 110, Issue:14

    Topics: Amidohydrolases; Angiotensin II; Animals; Arachidonic Acids; Benzamides; Benzyl Compounds; Blood Pressure; Camphanes; Carbamates; Dronabinol; Endocannabinoids; Endothelium, Vascular; Hypertension; Male; Models, Cardiovascular; Myocardial Contraction; Myocardium; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rats; Rats, Inbred Dahl; Rats, Inbred SHR; Rats, Inbred WKY; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Rimonabant; Up-Regulation; Vascular Resistance; Vasodilation; Ventricular Function, Left

2004
Characterization of the fatty acid amide hydrolase inhibitor cyclohexyl carbamic acid 3'-carbamoyl-biphenyl-3-yl ester (URB597): effects on anandamide and oleoylethanolamide deactivation.
    The Journal of pharmacology and experimental therapeutics, 2005, Volume: 313, Issue:1

    Topics: Amidohydrolases; Animals; Arachidonic Acids; Benzamides; Body Temperature; Brain; Calcium Channel Blockers; Carbamates; Chromatography, High Pressure Liquid; Drug Synergism; Duodenum; Endocannabinoids; Enzyme Inhibitors; Feeding Behavior; Male; Mass Spectrometry; Mice; Mice, Inbred C57BL; Oleic Acids; Polyunsaturated Alkamides; PPAR alpha; Rats; Rats, Wistar

2005
Cannabinoid agonists but not inhibitors of endogenous cannabinoid transport or metabolism enhance the reinforcing efficacy of heroin in rats.
    Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2005, Volume: 30, Issue:11

    Topics: Animals; Arachidonic Acids; Behavior, Animal; Benzamides; Benzoxazines; Cannabinoid Receptor Modulators; Cannabinoids; Carbamates; Conditioning, Operant; Dose-Response Relationship, Drug; Dronabinol; Drug Interactions; Heroin; Male; Morpholines; Naphthalenes; Narcotics; Rats; Rats, Sprague-Dawley; Reaction Time; Reinforcement Schedule; Reinforcement, Psychology; Self Administration; Time Factors

2005
Cisplatin increases brain 2-arachidonoylglycerol (2-AG) and concomitantly reduces intestinal 2-AG and anandamide levels in the least shrew.
    Neuropharmacology, 2005, Volume: 49, Issue:4

    Topics: Analysis of Variance; Animals; Apomorphine; Arachidonic Acids; Benzamides; Benzyl Compounds; Brain; Carbamates; Cisplatin; Dopamine Agonists; Dose-Response Relationship, Drug; Drug Interactions; Endocannabinoids; Female; Glycerides; Intestinal Mucosa; Intestines; Male; Radiation-Sensitizing Agents; Serotonin; Shrews; Time Factors; Vomiting

2005
A fluorescence-based assay for fatty acid amide hydrolase compatible with high-throughput screening.
    Analytical biochemistry, 2005, Aug-01, Volume: 343, Issue:1

    Topics: Amidohydrolases; Animals; Arachidonic Acids; Benzamides; Biological Assay; Carbamates; CHO Cells; Coumarins; Cricetinae; Cricetulus; Dose-Response Relationship, Drug; Enzyme Inhibitors; Fluorescence; Fluorescent Dyes; Humans; Microsomes

2005
Inhibitors of fatty acid amide hydrolase reduce carrageenan-induced hind paw inflammation in pentobarbital-treated mice: comparison with indomethacin and possible involvement of cannabinoid receptors.
    British journal of pharmacology, 2005, Volume: 146, Issue:3

    Topics: Amidohydrolases; Animals; Anti-Inflammatory Agents, Non-Steroidal; Benzamides; Brain; Camphanes; Cannabinoid Receptor Antagonists; Carbamates; Carrageenan; Disease Models, Animal; Enzyme Inhibitors; Hindlimb; Indomethacin; Inflammation; Male; Mice; Mice, Inbred C57BL; Pentobarbital; Phenylmethylsulfonyl Fluoride; Pyrazoles; Spinal Cord

2005
Involvement of N-acylethanolamine-hydrolyzing acid amidase in the degradation of anandamide and other N-acylethanolamines in macrophages.
    Biochimica et biophysica acta, 2005, Oct-01, Volume: 1736, Issue:3

    Topics: Amides; Amidohydrolases; Animals; Arachidonic Acids; Benzamides; Brain; Carbamates; Cell Line; Cell Line, Tumor; Endocannabinoids; Enzyme Inhibitors; Ethanolamines; Gene Expression; Humans; Kidney; Liver; Lung; Macrophages; Macrophages, Peritoneal; Male; Mice; Mice, Inbred C57BL; Polyunsaturated Alkamides; Rats; Rats, Wistar; U937 Cells

2005
Involvement of the endogenous cannabinoid system in the effects of alcohol in the mesolimbic reward circuit: electrophysiological evidence in vivo.
    Psychopharmacology, 2005, Volume: 183, Issue:3

    Topics: Animals; Benzamides; Cannabinoid Receptor Modulators; Carbamates; Dose-Response Relationship, Drug; Ethanol; Male; Nucleus Accumbens; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Reward; Rimonabant; Ventral Tegmental Area

2005
Elevation of endocannabinoid levels in the ventrolateral periaqueductal grey through inhibition of fatty acid amide hydrolase affects descending nociceptive pathways via both cannabinoid receptor type 1 and transient receptor potential vanilloid type-1 re
    The Journal of pharmacology and experimental therapeutics, 2006, Volume: 316, Issue:3

    Topics: Amidohydrolases; Analgesia; Animals; Benzamides; Benzoxazines; Cannabinoid Receptor Modulators; Carbamates; Endocannabinoids; Immunohistochemistry; Male; Medulla Oblongata; Morpholines; Naphthalenes; Pain; Periaqueductal Gray; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; TRPV Cation Channels

2006
Endocannabinoids at the spinal level regulate, but do not mediate, nonopioid stress-induced analgesia.
    Neuropharmacology, 2006, Volume: 50, Issue:3

    Topics: Analgesia; Analysis of Variance; Animals; Arachidonic Acids; Behavior, Animal; Benzamides; Carbamates; Dose-Response Relationship, Drug; Drug Interactions; Endocannabinoids; Glycerides; Male; Mass Spectrometry; Pain Measurement; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rats; Rats, Sprague-Dawley; Reaction Time; Rimonabant; Serotonin; Spinal Cord; Stress, Psychological; Time Factors

2006
Actions of the FAAH inhibitor URB597 in neuropathic and inflammatory chronic pain models.
    British journal of pharmacology, 2006, Volume: 147, Issue:3

    Topics: Amidohydrolases; Animals; Benzamides; Carbamates; Chronic Disease; Disease Models, Animal; Enzyme Inhibitors; Hyperalgesia; Inflammation; Male; Motor Activity; Neuralgia; Pain; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; TRPV Cation Channels

2006
Antidepressant-like activity and modulation of brain monoaminergic transmission by blockade of anandamide hydrolysis.
    Proceedings of the National Academy of Sciences of the United States of America, 2005, Dec-20, Volume: 102, Issue:51

    Topics: Animals; Antidepressive Agents; Arachidonic Acids; Behavior, Animal; Benzamides; Brain; Cannabinoid Receptor Agonists; Carbamates; Dronabinol; Endocannabinoids; Hydrolysis; Male; Mice; Mice, Inbred C57BL; Neurons; Norepinephrine; Polyunsaturated Alkamides; Rats; Receptors, Cannabinoid; Serotonin

2005
Role of the basolateral nucleus of the amygdala in endocannabinoid-mediated stress-induced analgesia.
    Neuroscience letters, 2006, Apr-24, Volume: 397, Issue:3

    Topics: Amidohydrolases; Amygdala; Animals; Benzamides; Biphenyl Compounds; Cannabinoid Receptor Modulators; Carbamates; Endocannabinoids; Male; Microinjections; Monoacylglycerol Lipases; Pain; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Rimonabant; Stress, Psychological

2006
The endocannabinoid system promotes astroglial differentiation by acting on neural progenitor cells.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2006, Feb-01, Volume: 26, Issue:5

    Topics: Amidohydrolases; Animals; Apoptosis; Astrocytes; Benzamides; Benzoxazines; Cannabinoid Receptor Modulators; Cannabinoids; Carbamates; Cell Differentiation; Cells, Cultured; Endocannabinoids; Enzyme Inhibitors; Glial Fibrillary Acidic Protein; Hippocampus; Intermediate Filament Proteins; Mice; Mice, Knockout; Morpholines; Naphthalenes; Nerve Tissue Proteins; Nestin; Neurons; Rats; Receptor, Cannabinoid, CB1; Stem Cells

2006
Genetic impairment of frontocortical endocannabinoid degradation and high alcohol preference.
    Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2007, Volume: 32, Issue:1

    Topics: Alcohol Drinking; Amidohydrolases; Analgesics; Animals; Behavior, Animal; Benzamides; Benzoxazines; Brain Chemistry; Cannabinoid Receptor Modulators; Carbamates; Central Nervous System Depressants; Dose-Response Relationship, Drug; Drug Interactions; Endocannabinoids; Ethanol; Gene Expression; Guanosine 5'-O-(3-Thiotriphosphate); In Situ Hybridization; Male; Morpholines; Naphthalenes; Piperidines; Prefrontal Cortex; Pyrazoles; Rats; Receptor, Cannabinoid, CB1; Reverse Transcriptase Polymerase Chain Reaction; Rimonabant; RNA, Messenger; Self Administration

2007
A novel scintillation proximity assay for fatty acid amide hydrolase compatible with inhibitor screening.
    Analytical biochemistry, 2006, Jul-01, Volume: 354, Issue:1

    Topics: Amidohydrolases; Animals; Arachidonic Acids; Benzamides; Binding Sites; Calcium Channel Blockers; Carbamates; CHO Cells; Cricetinae; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Endocannabinoids; Enzyme Inhibitors; Humans; Inhibitory Concentration 50; Ligands; Microsomes; Polyunsaturated Alkamides; Scintillation Counting; Wheat Germ Agglutinins

2006
Evaluation of the role of nicotinic acetylcholine receptor subtypes and cannabinoid system in the discriminative stimulus effects of nicotine in rats.
    European journal of pharmacology, 2006, Jul-01, Volume: 540, Issue:1-3

    Topics: Aconitine; Animals; Arachidonic Acids; Azetidines; Benzamides; Benzoxazines; Camphanes; Cannabinoid Receptor Antagonists; Carbamates; Cyclohexanols; Dihydro-beta-Erythroidine; Discrimination Learning; Dose-Response Relationship, Drug; Drug Synergism; Endocannabinoids; Male; Mecamylamine; Morpholines; Naphthalenes; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Polyunsaturated Alkamides; Pyrazoles; Pyridines; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Receptors, Cannabinoid; Receptors, Nicotinic

2006
Anandamide administration alone and after inhibition of fatty acid amide hydrolase (FAAH) increases dopamine levels in the nucleus accumbens shell in rats.
    Journal of neurochemistry, 2006, Volume: 98, Issue:2

    Topics: Amidohydrolases; Animals; Arachidonic Acids; Benzamides; Calcium; Cannabinoids; Carbamates; Data Interpretation, Statistical; Dopamine; Endocannabinoids; Enzyme Inhibitors; Male; Microdialysis; Nucleus Accumbens; Polyunsaturated Alkamides; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Synaptic Transmission; Tetrodotoxin; TRPV Cation Channels

2006
A role for vanilloid receptor 1 (TRPV1) and endocannabinnoid signalling in the regulation of spontaneous and L-DOPA induced locomotion in normal and reserpine-treated rats.
    Neuropharmacology, 2006, Volume: 51, Issue:3

    Topics: Adrenergic Uptake Inhibitors; Analysis of Variance; Animals; Arachidonic Acids; Behavior, Animal; Benzamides; Benzyl Compounds; Cannabinoid Receptor Modulators; Capsaicin; Carbamates; Dopamine Agents; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Inhibitors; Levodopa; Male; Motor Activity; Rats; Rats, Sprague-Dawley; Reserpine; Signal Transduction; TRPV Cation Channels

2006
A FAAH-regulated class of N-acyl taurines that activates TRP ion channels.
    Biochemistry, 2006, Aug-01, Volume: 45, Issue:30

    Topics: Amidohydrolases; Animals; Benzamides; Carbamates; CHO Cells; Cricetinae; Enzyme Inhibitors; Mice; Mice, Knockout; Taurine; Tissue Distribution; TRPV Cation Channels

2006
The putative endocannabinoid transport blocker LY2183240 is a potent inhibitor of FAAH and several other brain serine hydrolases.
    Journal of the American Chemical Society, 2006, Aug-02, Volume: 128, Issue:30

    Topics: Amidohydrolases; Animals; Antineoplastic Combined Chemotherapy Protocols; Benzamides; Brain; Cannabinoid Receptor Modulators; Carbamates; Cisplatin; Endocannabinoids; Gene Deletion; Heterocyclic Compounds, 1-Ring; Hydrolases; Ifosfamide; Male; Mice; Mice, Inbred C57BL; Mitomycin; Molecular Structure; Urea

2006
Synthesis and structure-activity relationships of FAAH inhibitors: cyclohexylcarbamic acid biphenyl esters with chemical modulation at the proximal phenyl ring.
    ChemMedChem, 2006, Volume: 1, Issue:1

    Topics: Amidohydrolases; Benzamides; Carbamates; Enzyme Inhibitors; Magnetic Resonance Spectroscopy; Models, Molecular; Quantitative Structure-Activity Relationship

2006
Non-cannabinoid CB1, non-cannabinoid CB2 antinociceptive effects of several novel compounds in the PPQ stretch test in mice.
    European journal of pharmacology, 2006, Sep-28, Volume: 546, Issue:1-3

    Topics: Acetaminophen; Amides; Analgesics; Animals; Arachidonic Acids; Benzamides; Benzoquinones; Camphanes; Capsaicin; Carbamates; Dose-Response Relationship, Drug; Dronabinol; Endocannabinoids; Ethanolamines; Hyperalgesia; Male; Mesencephalon; Mice; Mice, Inbred ICR; Narcotic Antagonists; Pain; Palmitic Acids; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Receptors, Opioid; Rimonabant; Spinal Cord; TRPV Cation Channels

2006
The fatty-acid amide hydrolase inhibitor URB597 does not affect triacylglycerol hydrolysis in rat tissues.
    Pharmacological research, 2006, Volume: 54, Issue:5

    Topics: Adipose Tissue, White; Amidohydrolases; Animals; Benzamides; Brain; Carbamates; Enzyme Inhibitors; Hydrolysis; Liver; Male; Myocardium; Rats; Rats, Wistar; Triglycerides; Triolein

2006
Effects of endocannabinoid neurotransmission modulators on brain stimulation reward.
    Psychopharmacology, 2006, Volume: 188, Issue:3

    Topics: Amidohydrolases; Animals; Arachidonic Acids; Benzamides; Benzyl Compounds; Brain; Cannabinoid Receptor Modulators; Carbamates; Conditioning, Operant; Dose-Response Relationship, Drug; Electric Stimulation; Endocannabinoids; Injections, Intraperitoneal; Male; Medial Forebrain Bundle; Phenylmethylsulfonyl Fluoride; Piperidines; Polyunsaturated Alkamides; Protease Inhibitors; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Reinforcement Schedule; Reward; Rimonabant; Self Stimulation; Synaptic Transmission

2006
The potency of the fatty acid amide hydrolase inhibitor URB597 is dependent upon the assay pH.
    Pharmacological research, 2006, Volume: 54, Issue:6

    Topics: Amidohydrolases; Animals; Benzamides; Brain; Brain Neoplasms; Carbamates; Enzyme Inhibitors; Ethanolamine; Glioma; Hydrogen-Ion Concentration; Male; Rats; Rats, Sprague-Dawley; Rats, Wistar

2006
Enhancement of endocannabinoid signalling during adolescence: Modulation of impulsivity and long-term consequences on metabolic brain parameters in early maternally deprived rats.
    Pharmacology, biochemistry, and behavior, 2007, Volume: 86, Issue:2

    Topics: Amidohydrolases; Animals; Benzamides; Brain; Brain Chemistry; Cannabinoid Receptor Modulators; Carbamates; Conditioning, Operant; Endocannabinoids; Enzyme Inhibitors; Female; Hippocampus; Impulsive Behavior; Magnetic Resonance Spectroscopy; Maternal Deprivation; Motor Activity; Neostriatum; Nucleus Accumbens; Pregnancy; Rats; Rats, Wistar; Signal Transduction; Weight Gain

2007
Effects of the FAAH inhibitor, URB597, and anandamide on lithium-induced taste reactivity responses: a measure of nausea in the rat.
    Psychopharmacology, 2007, Volume: 190, Issue:2

    Topics: Amidohydrolases; Animals; Arachidonic Acids; Association Learning; Avoidance Learning; Benzamides; Carbamates; Conditioning, Classical; Dose-Response Relationship, Drug; Endocannabinoids; Injections, Intraperitoneal; Lithium Chloride; Male; Nausea; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rats; Rats, Long-Evans; Receptor, Cannabinoid, CB1; Vomiting

2007
Analgesic effects of fatty acid amide hydrolase inhibition in a rat model of neuropathic pain.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2006, Dec-20, Volume: 26, Issue:51

    Topics: Amidohydrolases; Analgesics; Animals; Benzamides; Carbamates; Disease Models, Animal; Enzyme Inhibitors; Injections, Spinal; Male; Pain; Pain Measurement; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1

2006
The endogenous cannabinoid anandamide produces delta-9-tetrahydrocannabinol-like discriminative and neurochemical effects that are enhanced by inhibition of fatty acid amide hydrolase but not by inhibition of anandamide transport.
    The Journal of pharmacology and experimental therapeutics, 2007, Volume: 321, Issue:1

    Topics: Amidohydrolases; Animals; Arachidonic Acids; Benzamides; Biological Transport, Active; Brain Chemistry; Carbamates; Discrimination Learning; Discrimination, Psychological; Dose-Response Relationship, Drug; Dronabinol; Endocannabinoids; Enzyme Inhibitors; Furans; Hallucinogens; Injections, Intraperitoneal; Injections, Intravenous; Male; Microdialysis; Nucleus Accumbens; Polyunsaturated Alkamides; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Reinforcement Schedule; TRPV Cation Channels

2007
Fatty acid amide hydrolase inhibitors display broad selectivity and inhibit multiple carboxylesterases as off-targets.
    Neuropharmacology, 2007, Volume: 52, Issue:4

    Topics: Amidohydrolases; Animals; Antibodies; Benzamides; Brain; Carbamates; Carboxylesterase; Cell Line, Tumor; Enzyme Activation; Enzyme Inhibitors; Heart; Humans; Kidney; Liver; Proteome; Rats; Transfection

2007
Effects of inhibition of fatty acid amide hydrolase vs. the anandamide membrane transporter on TRPV1-mediated calcium responses in adult DRG neurons; the role of CB receptors.
    The European journal of neuroscience, 2006, Volume: 24, Issue:12

    Topics: Amidohydrolases; Animals; Arachidonic Acids; Benzamides; Calcium; Capsaicin; Carbamates; Cells, Cultured; Dopamine; Drug Interactions; Endocannabinoids; Fura-2; Furans; Ganglia, Spinal; Male; Membrane Potentials; Membrane Transport Proteins; Neurons; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rats; Rats, Sprague-Dawley; TRPV Cation Channels

2006
Endothelium-dependent metabolism by endocannabinoid hydrolases and cyclooxygenases limits vasorelaxation to anandamide and 2-arachidonoylglycerol.
    British journal of pharmacology, 2007, Volume: 150, Issue:5

    Topics: Amidohydrolases; Animals; Arachidonic Acids; Benzamides; Cannabinoid Receptor Modulators; Carbamates; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Endocannabinoids; Endothelium, Vascular; Enzyme Inhibitors; Glycerides; Hydrolases; In Vitro Techniques; Lectins; Lectins, C-Type; Male; Membrane Proteins; Mesenteric Artery, Superior; Organophosphonates; Polyunsaturated Alkamides; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Wistar; Receptors, Cell Surface; Vasodilation; Vasodilator Agents

2007
Visualization of 2-arachidonoylglycerol accumulation and cannabinoid CB1 receptor activity in rat brain cryosections by functional autoradiography.
    Journal of neurochemistry, 2007, Volume: 101, Issue:4

    Topics: Animals; Arachidonic Acids; Autoradiography; Benzamides; Binding, Competitive; Brain; Carbamates; Cryoultramicrotomy; Drug Interactions; Endocannabinoids; Enzyme Inhibitors; Glycerides; Guanosine 5'-O-(3-Thiotriphosphate); Male; Organophosphonates; Piperidines; Pyrazoles; Radiography; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Sulfones

2007
Interactions between endocannabinoids and stress-induced decreased sensitivity to natural reward.
    Progress in neuro-psychopharmacology & biological psychiatry, 2007, Apr-13, Volume: 31, Issue:3

    Topics: Analysis of Variance; Animals; Behavior, Animal; Benzamides; Body Weight; Cannabinoid Receptor Modulators; Carbamates; Cyclohexanes; Cyclohexanols; Dose-Response Relationship, Drug; Drinking Behavior; Drug Interactions; Endocannabinoids; Food Deprivation; Food Preferences; Male; Mice; Mice, Inbred ICR; Phenols; Piperidines; Pyrazoles; Restraint, Physical; Reward; Rimonabant; Stress, Psychological; Sucrose; Time Factors; Water Deprivation

2007
Pharmacological characterization of receptor types mediating the dilator action of anandamide on blood vessels of the rat knee joint.
    Life sciences, 2007, Mar-27, Volume: 80, Issue:16

    Topics: Amidohydrolases; Analysis of Variance; Animals; Arachidonic Acids; Benzamides; Blood Vessels; Cannabinoid Receptor Antagonists; Cannabinoid Receptor Modulators; Capsaicin; Carbamates; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Endocannabinoids; Flurbiprofen; Hindlimb; Indoles; Joints; Morpholines; Polyunsaturated Alkamides; Pyrazoles; Rats; Regional Blood Flow; TRPV Cation Channels; Vasodilation

2007
Evaluation of fatty acid amide hydrolase inhibition in murine models of emotionality.
    Psychopharmacology, 2007, Volume: 192, Issue:1

    Topics: Amidohydrolases; Animals; Anxiety; Arachidonic Acids; Behavior, Animal; Benzamides; Cannabinoid Receptor Modulators; Carbamates; Depression; Disease Models, Animal; Dose-Response Relationship, Drug; Emotions; Endocannabinoids; Enzyme Inhibitors; Lighting; Maze Learning; Mice; Mice, Knockout; Polyunsaturated Alkamides; Pyridines; Signal Transduction

2007
Endocannabinoid-mediated rescue of striatal LTD and motor deficits in Parkinson's disease models.
    Nature, 2007, Feb-08, Volume: 445, Issue:7128

    Topics: Animals; Benzamides; Benzoxazines; Cannabinoid Receptor Modulators; Carbamates; Disease Models, Animal; Dopamine; Dopamine D2 Receptor Antagonists; Endocannabinoids; Excitatory Postsynaptic Potentials; In Vitro Techniques; Long-Term Synaptic Depression; Mice; Mice, Transgenic; Morpholines; Naphthalenes; Neostriatum; Neuronal Plasticity; Oxidopamine; Parkinson Disease; Piperidines; Psychomotor Performance; Pyrazoles; Receptor, Cannabinoid, CB1; Receptors, Dopamine D2; Receptors, N-Methyl-D-Aspartate; Reserpine; Synapses

2007
Activation of TRPA1 channels by the fatty acid amide hydrolase inhibitor 3'-carbamoylbiphenyl-3-yl cyclohexylcarbamate (URB597).
    Molecular pharmacology, 2007, Volume: 71, Issue:5

    Topics: Amidohydrolases; Animals; Ankyrins; Benzamides; Calcium Channels; Carbamates; Cell Membrane; Ganglia, Spinal; Gene Expression; Humans; Ion Channel Gating; Male; Nerve Tissue Proteins; Neurons; Rats; Rats, Sprague-Dawley; Transfection; Transient Receptor Potential Channels; TRPA1 Cation Channel; TRPC Cation Channels; TRPM Cation Channels; TRPV Cation Channels

2007
The 'specific' tyrosine kinase inhibitor genistein inhibits the enzymic hydrolysis of anandamide: implications for anandamide uptake.
    British journal of pharmacology, 2007, Volume: 150, Issue:7

    Topics: Amidohydrolases; Animals; Arachidonic Acids; Benzamides; Brain; Carbamates; Cell Line, Tumor; Endocannabinoids; Genistein; Hydrolysis; Mice; Nystatin; Polyunsaturated Alkamides; Progesterone; Protein Kinase Inhibitors; Protein-Tyrosine Kinases; Rats

2007
Effects of the fatty acid amide hydrolase inhibitor URB597 on the sleep-wake cycle, c-Fos expression and dopamine levels of the rat.
    European journal of pharmacology, 2007, May-07, Volume: 562, Issue:1-2

    Topics: Amides; Amidohydrolases; Analgesics; Animals; Benzamides; Carbamates; Dopamine; Dose-Response Relationship, Drug; Endocannabinoids; Ethanolamines; Hippocampus; Injections, Intraventricular; Levodopa; Male; Microdialysis; Nucleus Accumbens; Oleic Acids; Palmitic Acids; Proto-Oncogene Proteins c-fos; Raphe Nuclei; Rats; Rats, Wistar; Sleep; Time Factors; Wakefulness

2007
The fatty acid amide hydrolase inhibitor URB597 (cyclohexylcarbamic acid 3'-carbamoylbiphenyl-3-yl ester) reduces neuropathic pain after oral administration in mice.
    The Journal of pharmacology and experimental therapeutics, 2007, Volume: 322, Issue:1

    Topics: Administration, Oral; Amidohydrolases; Analgesics; Animals; Benzamides; Capillary Permeability; Carbamates; Enzyme Inhibitors; Hyperalgesia; Male; Mice; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Spinal Cord

2007
Interactions of cannabidiol with endocannabinoid signalling in hippocampal tissue.
    The European journal of neuroscience, 2007, Volume: 25, Issue:7

    Topics: Animals; Arachidonic Acids; Benzamides; Calcium; Cannabidiol; Cannabinoid Receptor Modulators; Carbamates; Cells, Cultured; Dronabinol; Endocannabinoids; Estrenes; Glutamic Acid; Glycerides; Hippocampus; Humans; Morpholines; Pertussis Toxin; Phosphodiesterase Inhibitors; Polyunsaturated Alkamides; Pyrazoles; Pyrrolidinones; Rats; Receptor, Cannabinoid, CB1; Signal Transduction

2007
Antidepressant-like activity of the fatty acid amide hydrolase inhibitor URB597 in a rat model of chronic mild stress.
    Biological psychiatry, 2007, Nov-15, Volume: 62, Issue:10

    Topics: Amidohydrolases; Animals; Antidepressive Agents; Behavior, Animal; Benzamides; Body Weight; Brain; Cannabinoid Receptor Modulators; Carbamates; Chronic Disease; Disease Models, Animal; Dose-Response Relationship, Drug; Gene Expression Regulation; Imipramine; Lipid Metabolism; Male; Multivariate Analysis; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Stress, Psychological; Sucrose; Time Factors

2007
Inhibition of microglial fatty acid amide hydrolase modulates LPS stimulated release of inflammatory mediators.
    FEBS letters, 2007, Jun-26, Volume: 581, Issue:16

    Topics: Amidohydrolases; Animals; Benzamides; Carbamates; Cells, Cultured; Cyclooxygenase 2; Dinoprostone; Inflammation Mediators; Lipopolysaccharides; Microglia; Nitric Oxide; Nitric Oxide Synthase Type II; Rats; Tumor Necrosis Factor-alpha

2007
Involvement of the endocannabinoid system in retinal damage after high intraocular pressure-induced ischemia in rats.
    Investigative ophthalmology & visual science, 2007, Volume: 48, Issue:7

    Topics: Amidohydrolases; Animals; Arachidonic Acids; Benzamides; Cannabinoid Receptor Modulators; Capsaicin; Carbamates; Cell Count; Chromatography, High Pressure Liquid; Endocannabinoids; Enzyme Inhibitors; Enzyme-Linked Immunosorbent Assay; Hydrolysis; Intraocular Pressure; Male; Ocular Hypertension; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Reperfusion Injury; Retinal Diseases; Retinal Ganglion Cells; Retinal Vessels; Reverse Transcriptase Polymerase Chain Reaction; Rimonabant; RNA, Messenger; Thy-1 Antigens; TRPV Cation Channels

2007
Design, synthesis, and in vitro evaluation of carbamate derivatives of 2-benzoxazolyl- and 2-benzothiazolyl-(3-hydroxyphenyl)-methanones as novel fatty acid amide hydrolase inhibitors.
    Journal of medicinal chemistry, 2007, Aug-23, Volume: 50, Issue:17

    Topics: Amidohydrolases; Animals; Benzamides; Benzothiazoles; Benzoxazoles; Brain; Carbamates; Drug Design; In Vitro Techniques; Male; Monoacylglycerol Lipases; Rats; Rats, Wistar; Structure-Activity Relationship

2007
Inhibition of the cellular uptake of anandamide by genistein and its analogue daidzein in cells with different levels of fatty acid amide hydrolase-driven uptake.
    British journal of pharmacology, 2007, Volume: 152, Issue:5

    Topics: 3T3-L1 Cells; Amidohydrolases; Animals; Arachidonic Acids; Benzamides; Biological Transport; Carbamates; Cell Line, Tumor; Dose-Response Relationship, Drug; Endocannabinoids; Genistein; Humans; Hydrogen-Ion Concentration; Hydrolysis; Isoflavones; Male; Mice; Molecular Structure; Polyunsaturated Alkamides; Protein Kinase Inhibitors; Rats; Tritium

2007
Endocannabinoid modulation of male rat sexual behavior.
    Psychopharmacology, 2008, Volume: 198, Issue:4

    Topics: Amidohydrolases; Animals; Appetitive Behavior; Arachidonic Acids; Benzamides; Cannabinoid Receptor Modulators; Carbamates; Consummatory Behavior; Dose-Response Relationship, Drug; Ejaculation; Endocannabinoids; Enzyme Inhibitors; Male; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rats; Rats, Long-Evans; Receptor, Cannabinoid, CB1; Sexual Behavior, Animal

2008
Characterization of the vasorelaxant mechanisms of the endocannabinoid anandamide in rat aorta.
    British journal of pharmacology, 2007, Volume: 152, Issue:5

    Topics: Animals; Aorta, Abdominal; Apamin; Arachidonic Acids; Benzamides; Calcitonin Gene-Related Peptide; Camphanes; Cannabinoid Receptor Modulators; Capsaicin; Carbamates; Charybdotoxin; Dose-Response Relationship, Drug; Endocannabinoids; Endothelium, Vascular; In Vitro Techniques; Indomethacin; Isoindoles; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Peptide Fragments; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Rimonabant; Sulfonamides; Vasodilation

2007
Reduced anxiety-like behaviour induced by genetic and pharmacological inhibition of the endocannabinoid-degrading enzyme fatty acid amide hydrolase (FAAH) is mediated by CB1 receptors.
    Neuropharmacology, 2008, Volume: 54, Issue:1

    Topics: Amidohydrolases; Analysis of Variance; Animals; Anxiety; Arachidonic Acids; Behavior, Animal; Benzamides; Carbamates; Disease Models, Animal; Endocannabinoids; Glycerides; Male; Maze Learning; Mice; Mice, Inbred C57BL; Mice, Knockout; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant

2008
Local enhancement of cannabinoid CB1 receptor signalling in the dorsal hippocampus elicits an antidepressant-like effect.
    Behavioural pharmacology, 2007, Volume: 18, Issue:5-6

    Topics: Analysis of Variance; Animals; Antidepressive Agents; Behavior, Animal; Benzamides; Cannabinoid Receptor Modulators; Carbamates; Dentate Gyrus; Depression; Disease Models, Animal; Dronabinol; Hippocampus; Male; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Stress, Psychological; Swimming

2007
Changes in brain levels of N-acylethanolamines and 2-arachidonoylglycerol in focal cerebral ischemia in mice.
    Journal of neurochemistry, 2007, Volume: 103, Issue:5

    Topics: Analysis of Variance; Animals; Arachidonic Acids; Benzamides; Brain; Brain Infarction; Brain Ischemia; Carbamates; Disease Models, Animal; Endocannabinoids; Enzyme Inhibitors; Ethanolamines; Glycerides; Male; Mice; RNA, Messenger; Time Factors

2007
Inhibition of 2-arachidonoylglycerol catabolism modulates vasoconstriction of rat middle cerebral artery by the thromboxane mimetic, U-46619.
    British journal of pharmacology, 2007, Volume: 152, Issue:5

    Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Amidohydrolases; Aniline Compounds; Animals; Arachidonic Acid; Arachidonic Acids; Benzamides; Benzoxazines; Carbamates; Dose-Response Relationship, Drug; Drug Synergism; Endocannabinoids; Enzyme Inhibitors; Glycerides; In Vitro Techniques; Male; Middle Cerebral Artery; Morpholines; Naphthalenes; Nimodipine; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Rimonabant; Thromboxanes; Vasoconstriction; Vasoconstrictor Agents

2007
Anti-dyskinetic effects of cannabinoids in a rat model of Parkinson's disease: role of CB(1) and TRPV1 receptors.
    Experimental neurology, 2007, Volume: 208, Issue:1

    Topics: Amidohydrolases; Animals; Antiparkinson Agents; Arachidonic Acids; Basal Ganglia; Benzamides; Benzoxazines; Cannabinoids; Capsaicin; Carbamates; Drug Therapy, Combination; Dyskinesia, Drug-Induced; Endocannabinoids; Levodopa; Male; Morpholines; Naphthalenes; Oxidopamine; Parkinson Disease, Secondary; Polyunsaturated Alkamides; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; TRPV Cation Channels

2007
The endogenous cannabinoid anandamide has effects on motivation and anxiety that are revealed by fatty acid amide hydrolase (FAAH) inhibition.
    Neuropharmacology, 2008, Volume: 54, Issue:1

    Topics: Amidohydrolases; Analgesics; Analysis of Variance; Animals; Anxiety; Arachidonic Acids; Avoidance Learning; Behavior, Animal; Benzamides; Benzoxazines; Carbamates; Conditioning, Operant; Dose-Response Relationship, Drug; Endocannabinoids; Enzyme Inhibitors; Male; Morpholines; Motivation; Motor Activity; Naphthalenes; Polyunsaturated Alkamides; Rats; Rats, Sprague-Dawley; Time Factors

2008
Role in anxiety behavior of the endocannabinoid system in the prefrontal cortex.
    Cerebral cortex (New York, N.Y. : 1991), 2008, Volume: 18, Issue:6

    Topics: Animals; Anxiety; Arachidonic Acids; Benzamides; Cannabinoid Receptor Modulators; Carbamates; Dose-Response Relationship, Drug; Endocannabinoids; Male; Polyunsaturated Alkamides; Prefrontal Cortex; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1

2008
Manipulation of fatty acid amide hydrolase functional activity alters sensitivity and dependence to ethanol.
    Journal of neurochemistry, 2008, Volume: 104, Issue:1

    Topics: Alcohol Drinking; Amidohydrolases; Analgesics; Analgesics, Opioid; Animals; Behavior, Animal; Benzamides; Benzoxazines; Carbamates; Central Nervous System Depressants; Choice Behavior; Drug Interactions; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Ethanol; Guanosine 5'-O-(3-Thiotriphosphate); Hypothermia; Mice; Mice, Inbred C57BL; Mice, Knockout; Morpholines; Motor Activity; Naphthalenes; Protein Binding; Protein Precursors; Receptor, Cannabinoid, CB1

2008
Novel mechanistic class of fatty acid amide hydrolase inhibitors with remarkable selectivity.
    Biochemistry, 2007, Nov-13, Volume: 46, Issue:45

    Topics: Amidohydrolases; Anilides; Animals; Benzamides; Binding Sites; Carbamates; Enzyme Inhibitors; Humans; Inhibitory Concentration 50; Mice; Piperazines; Piperidines; Serine; Time Factors

2007
The effect of cannabidiol and URB597 on conditioned gaping (a model of nausea) elicited by a lithium-paired context in the rat.
    Psychopharmacology, 2008, Volume: 196, Issue:3

    Topics: Amidohydrolases; Animals; Antiemetics; Antineoplastic Agents; Benzamides; Cannabidiol; Carbamates; Conditioning, Classical; Disease Models, Animal; Dose-Response Relationship, Drug; Lithium Chloride; Male; Nausea; Rats; Rats, Long-Evans; Rats, Sprague-Dawley; Vomiting, Anticipatory

2008
CB1 receptor-mediated control of the release of endocannabinoids (as assessed by microdialysis coupled with LC/MS) in the rat hypothalamus.
    The European journal of neuroscience, 2007, Volume: 26, Issue:12

    Topics: Amidohydrolases; Animals; Arachidonic Acids; Benzamides; Benzoxazines; Cannabinoid Receptor Modulators; Cannabinoids; Carbamates; Chromatography, Liquid; Endocannabinoids; Extracellular Fluid; Glycerides; Hypothalamus; Male; Microdialysis; Morpholines; Naphthalenes; Piperidines; Polyunsaturated Alkamides; Potassium; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Rimonabant; Tandem Mass Spectrometry

2007
Bidirectional cannabinoid modulation of social behavior in adolescent rats.
    Psychopharmacology, 2008, Volume: 197, Issue:2

    Topics: Analgesics, Opioid; Animals; Benzamides; Benzoxazines; Cannabinoids; Carbamates; Dopamine; Dopamine Antagonists; Exploratory Behavior; Flupenthixol; Male; Morphine; Morpholines; Motor Activity; Naloxone; Naphthalenes; Narcotic Antagonists; Piperidines; Play and Playthings; Pyrazoles; Rats; Rats, Wistar; Receptors, Dopamine; Reward; Rimonabant; Social Behavior

2008
Interaction between cannabinoid compounds and diazepam on anxiety-like behaviour of mice.
    Pharmacology, biochemistry, and behavior, 2008, Volume: 89, Issue:1

    Topics: Amidohydrolases; Animals; Anxiety; Arachidonic Acids; Behavior, Animal; Benzamides; Benzoxazines; Cannabinoids; Carbamates; Data Interpretation, Statistical; Diazepam; Dose-Response Relationship, Drug; Drug Combinations; Drug Interactions; Enzyme Inhibitors; GABA Modulators; Hypnotics and Sedatives; Male; Mice; Morpholines; Naphthalenes; Piperidines; Postural Balance; Pyrazoles; Receptor, Cannabinoid, CB1

2008
A comprehensive profile of brain enzymes that hydrolyze the endocannabinoid 2-arachidonoylglycerol.
    Chemistry & biology, 2007, Volume: 14, Issue:12

    Topics: Animals; Arachidonic Acids; Benzamides; Biotin; Brain; Carbamates; Catalysis; Chlorocebus aethiops; COS Cells; Endocannabinoids; Enzyme Inhibitors; Glycerides; Hydrolases; Lactones; Membrane Proteins; Mice; Mice, Inbred C57BL; Monoacylglycerol Lipases; Organophosphorus Compounds; Orlistat; Proteomics; Subcellular Fractions; Transfection

2007
Augmentation of endogenous cannabinoid tone modulates lipopolysaccharide-induced alterations in circulating cytokine levels in rats.
    Immunology, 2008, Volume: 125, Issue:2

    Topics: Anilides; Animals; Arachidonic Acids; Benzamides; Cannabinoid Receptor Modulators; Carbamates; Cinnamates; Cytokines; Drug Synergism; Indoles; Interleukin-1beta; Interleukin-6; Lipopolysaccharides; Male; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Tumor Necrosis Factor-alpha

2008
N-palmitoyl glycine, a novel endogenous lipid that acts as a modulator of calcium influx and nitric oxide production in sensory neurons.
    Molecular pharmacology, 2008, Volume: 74, Issue:1

    Topics: Amidohydrolases; Animals; Antibodies; Benzamides; Brain Chemistry; Calcium; Carbamates; Cell Line; Crosses, Genetic; Dose-Response Relationship, Drug; Electrophysiology; Enzyme Inhibitors; Female; Ganglia, Spinal; Glycine; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Neurons, Afferent; Nitric Oxide; Nociceptors; Palmitic Acids; Pertussis Toxin; Rats; Rats, Sprague-Dawley; Receptors, Cannabinoid; Tissue Distribution; Up-Regulation

2008
Cannabinoid and opioid modulation of social play behavior in adolescent rats: differential behavioral mechanisms.
    European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology, 2008, Volume: 18, Issue:7

    Topics: Analgesics, Opioid; Analysis of Variance; Animals; Animals, Newborn; Behavior, Animal; Benzamides; Benzoxazines; Cannabinoids; Carbamates; Environment; Exploratory Behavior; Male; Morphine; Morpholines; Naphthalenes; Rats; Rats, Wistar; Recognition, Psychology; Social Behavior

2008
Increase of brain endocannabinoid anandamide levels by FAAH inhibition and alcohol abuse behaviours in the rat.
    Psychopharmacology, 2008, Volume: 198, Issue:4

    Topics: Adrenergic alpha-Antagonists; Alcohol Drinking; Alcoholism; Amidohydrolases; Animals; Anxiety; Arachidonic Acids; Benzamides; Brain Chemistry; Carbamates; Conditioning, Operant; Cues; Electroshock; Endocannabinoids; Enzyme Inhibitors; Extinction, Psychological; Male; Polyunsaturated Alkamides; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Recurrence; Reinforcement Schedule; Self Administration; Stress, Psychological; Yohimbine

2008
Targeting endocannabinoid degradation protects against experimental colitis in mice: involvement of CB1 and CB2 receptors.
    Journal of molecular medicine (Berlin, Germany), 2008, Volume: 86, Issue:8

    Topics: Amidohydrolases; Animals; Arachidonic Acids; Benzamides; Cannabinoid Receptor Modulators; Carbamates; Colitis; Crohn Disease; Disease Models, Animal; Endocannabinoids; Humans; Mice; Mice, Inbred C57BL; Polymorphism, Genetic; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; RNA, Messenger; Trinitrobenzenesulfonic Acid

2008
Inhibition of fatty acid amide hydrolase and cyclooxygenase-2 increases levels of endocannabinoid related molecules and produces analgesia via peroxisome proliferator-activated receptor-alpha in a model of inflammatory pain.
    Neuropharmacology, 2008, Volume: 55, Issue:1

    Topics: Amides; Amidohydrolases; Animals; Benzamides; Cannabinoid Receptor Modulators; Carbamates; Carrageenan; Cyclooxygenase 2; Disease Models, Animal; Dose-Response Relationship, Drug; Endocannabinoids; Enzyme Inhibitors; Ethanolamines; Guanosine 5'-O-(3-Thiotriphosphate); Hyperalgesia; Male; Pain Measurement; Palmitic Acids; PPAR alpha; Protein Binding; Rats; Rats, Sprague-Dawley; Sulfonamides; Time Factors; Weight-Bearing

2008
N-arachidonylethanolamide-induced increase in aqueous humor outflow facility.
    Investigative ophthalmology & visual science, 2008, Volume: 49, Issue:10

    Topics: Amidohydrolases; Animals; Anterior Eye Segment; Aqueous Humor; Arachidonic Acids; Benzamides; Blotting, Western; Camphanes; Cannabinoid Receptor Antagonists; Cannabinoid Receptor Modulators; Carbamates; Chromatography, Thin Layer; Endocannabinoids; Organ Culture Techniques; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Receptors, Cannabinoid; Rimonabant; Swine; Trabecular Meshwork

2008
An endocannabinoid signaling system modulates anxiety-like behavior in male Syrian hamsters.
    Psychopharmacology, 2008, Volume: 200, Issue:3

    Topics: Aggression; Amides; Amidohydrolases; Animals; Arousal; Autoradiography; Benzamides; Brain; Cannabinoid Receptor Modulators; Carbamates; Cricetinae; Dominance-Subordination; Endocannabinoids; Ethanolamines; Fear; Male; Maze Learning; Mesocricetus; Oleic Acids; Palmitic Acids; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant; Rotarod Performance Test; Signal Transduction; Social Environment

2008
Evaluation of interactions between cannabinoid compounds and diazepam in electroshock-induced seizure model in mice.
    Journal of neural transmission (Vienna, Austria : 1996), 2008, Volume: 115, Issue:11

    Topics: Amidohydrolases; Animals; Anticonvulsants; Arachidonic Acids; Benzamides; Benzoxazines; Cannabinoid Receptor Modulators; Cannabinoids; Carbamates; Diazepam; Drug Interactions; Electroshock; Enzyme Inhibitors; Male; Mice; Morpholines; Naphthalenes; Postural Balance; Receptor, Cannabinoid, CB1; Seizures

2008
Anxiolytic effects in mice of a dual blocker of fatty acid amide hydrolase and transient receptor potential vanilloid type-1 channels.
    Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2009, Volume: 34, Issue:3

    Topics: Amidohydrolases; Anilides; Animals; Anti-Anxiety Agents; Anxiety; Arachidonic Acids; Benzamides; Brain; Cannabinoid Receptor Modulators; Capsaicin; Carbamates; Cinnamates; Diazepam; Exploratory Behavior; Male; Mice; Mice, Inbred C57BL; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Serotonin; TRPV Cation Channels

2009
Effects of URB597 as an inhibitor of fatty acid amide hydrolase on modulation of nociception in a rat model of cholestasis.
    European journal of pharmacology, 2008, Sep-04, Volume: 591, Issue:1-3

    Topics: Amidohydrolases; Animals; Benzamides; Carbamates; Cholestasis; Disease Models, Animal; Injections, Intraperitoneal; Male; Pain; Pain Measurement; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2

2008
Activation of endocannabinoid transmission induces antidepressant-like effects in rats.
    Journal of physiology and pharmacology : an official journal of the Polish Physiological Society, 2008, Volume: 59, Issue:2

    Topics: Animals; Antidepressive Agents; Arachidonic Acids; Benzamides; Cannabinoid Receptor Modulators; Carbamates; Depression; Dose-Response Relationship, Drug; Endocannabinoids; Immobilization; Male; Motor Activity; Rats; Rats, Wistar; Synaptic Transmission

2008
Inhibition of endocannabinoid metabolism attenuates enhanced hippocampal neuronal activity induced by kainic acid.
    Synapse (New York, N.Y.), 2008, Volume: 62, Issue:10

    Topics: Animals; Benzamides; Cannabinoid Receptor Modulators; Carbamates; Dose-Response Relationship, Drug; Endocannabinoids; Hippocampus; Kainic Acid; Male; Neural Inhibition; Neurons; Piperidines; Pyrazoles; Rats

2008
Does the hydrolysis of 2-arachidonoylglycerol regulate its cellular uptake?
    Pharmacological research, 2008, Volume: 58, Issue:1

    Topics: Amidohydrolases; Animals; Arachidonic Acids; Benzamides; Biphenyl Compounds; Cannabinoid Receptor Modulators; Carbamates; Cell Line, Tumor; Endocannabinoids; Glycerides; Humans; Hydrolysis; Polyunsaturated Alkamides

2008
Activation of cannabinoid CB1 receptors in the dorsolateral periaqueductal gray induces anxiolytic effects in rats submitted to the Vogel conflict test.
    European journal of pharmacology, 2008, Sep-28, Volume: 593, Issue:1-3

    Topics: Amidohydrolases; Animals; Anti-Anxiety Agents; Arachidonic Acids; Benzamides; Carbamates; Conflict, Psychological; Data Interpretation, Statistical; Drinking; Endocannabinoids; Enzyme Inhibitors; Male; Pain Measurement; Periaqueductal Gray; Polyunsaturated Alkamides; Rats; Rats, Wistar; Reaction Time; Receptor, Cannabinoid, CB1

2008
Inhibition of fatty acid amide hydrolase produces PPAR-alpha-mediated analgesia in a rat model of inflammatory pain.
    British journal of pharmacology, 2008, Volume: 155, Issue:8

    Topics: Amidohydrolases; Analgesia; Animals; Benzamides; Carbamates; Carrageenan; Disease Models, Animal; Inflammation; Oxazoles; Pain; Piperidines; PPAR gamma; Pyrazoles; Rats; Receptor, Cannabinoid, CB1; Tyrosine

2008
Inhibition of anandamide hydrolysis by cyclohexyl carbamic acid 3'-carbamoyl-3-yl ester (URB597) reverses abuse-related behavioral and neurochemical effects of nicotine in rats.
    The Journal of pharmacology and experimental therapeutics, 2008, Volume: 327, Issue:2

    Topics: Amidohydrolases; Animals; Arachidonic Acids; Benzamides; Carbamates; Conditioning, Psychological; Dopamine; Endocannabinoids; Hydrolysis; Male; Motor Activity; Nicotine; Nucleus Accumbens; Polyunsaturated Alkamides; Rats; Rats, Long-Evans; Rats, Sprague-Dawley; Reward; Self Administration; Tobacco Use Disorder

2008
Modulation of opioids via protection of anandamide degradation by fatty acid amide hydrolase.
    European journal of pharmacology, 2008, Dec-14, Volume: 600, Issue:1-3

    Topics: Amidohydrolases; Analgesics, Opioid; Animals; Arachidonic Acids; Benzamides; Cannabinoid Receptor Modulators; Carbamates; Dose-Response Relationship, Drug; Drug Therapy, Combination; Endocannabinoids; Enzyme Inhibitors; Male; Mice; Mice, Inbred ICR; Mice, Knockout; Morphine; Pain; Polyunsaturated Alkamides; Receptor, Cannabinoid, CB1; Receptors, Opioid, kappa

2008
Fatty acid amide hydrolase inhibition heightens anandamide signaling without producing reinforcing effects in primates.
    Biological psychiatry, 2008, Dec-01, Volume: 64, Issue:11

    Topics: Amidohydrolases; Analysis of Variance; Animals; Arachidonic Acids; Behavior, Animal; Benzamides; Brain; Cannabinoid Receptor Modulators; Carbamates; Chromatography, Liquid; Cocaine; Dose-Response Relationship, Drug; Dronabinol; Endocannabinoids; Male; Polyunsaturated Alkamides; Rats; Rats, Wistar; Reinforcement Schedule; Reinforcement, Psychology; Saimiri; Self Administration

2008
Cannabinoids inhibit HIV-1 Gp120-mediated insults in brain microvascular endothelial cells.
    Journal of immunology (Baltimore, Md. : 1950), 2008, Nov-01, Volume: 181, Issue:9

    Topics: AIDS Dementia Complex; Amidohydrolases; Anti-HIV Agents; Arachidonic Acids; Benzamides; Blood-Brain Barrier; Brain; Cannabinoid Receptor Modulators; Carbamates; Cell Line; Coculture Techniques; Endocannabinoids; Endothelium, Vascular; Glycerides; HIV Envelope Protein gp120; HIV-1; Humans; Microcirculation; Receptor, Cannabinoid, CB1

2008
Endocannabinoid-mediated enhancement of fear-conditioned analgesia in rats: opioid receptor dependency and molecular correlates.
    Pain, 2008, Volume: 140, Issue:3

    Topics: Amidohydrolases; Amygdala; Analgesia; Animals; Arachidonic Acids; Avoidance Learning; Benzamides; Cannabinoid Receptor Modulators; Carbamates; Conditioning, Psychological; Endocannabinoids; Enzyme Inhibitors; Extracellular Signal-Regulated MAP Kinases; Fear; Male; Narcotic Antagonists; Neural Inhibition; Pain; Pain Measurement; Polyunsaturated Alkamides; Rats; Receptor, Cannabinoid, CB1; Receptors, Opioid; Signal Transduction

2008
The endocannabinoid system in bull sperm and bovine oviductal epithelium: role of anandamide in sperm-oviduct interaction.
    Reproduction (Cambridge, England), 2009, Volume: 137, Issue:3

    Topics: Amidohydrolases; Animals; Arachidonic Acids; Benzamides; Blotting, Western; Camphanes; Carbamates; Cattle; Endocannabinoids; Epithelium; Fallopian Tubes; Female; Immunohistochemistry; Male; Microscopy, Fluorescence; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Sperm Motility; Sperm-Ovum Interactions; Spermatozoa

2009
Endogenous fatty acid ethanolamides suppress nicotine-induced activation of mesolimbic dopamine neurons through nuclear receptors.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2008, Dec-17, Volume: 28, Issue:51

    Topics: Amides; Amidohydrolases; Animals; Appetite Depressants; Arachidonic Acids; Benzamides; Cannabinoid Receptor Antagonists; Carbamates; Dopamine; Endocannabinoids; Enzyme Activation; Enzyme Inhibitors; Ethanolamines; Injections, Intraventricular; Lipoxygenase Inhibitors; Male; Neurons; Nicotine; Oleic Acids; Organ Culture Techniques; Palmitic Acids; Patch-Clamp Techniques; Piperidines; PPAR alpha; Protein-Tyrosine Kinases; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptors, Cannabinoid; Rimonabant; Ventral Tegmental Area

2008
Synergy between enzyme inhibitors of fatty acid amide hydrolase and cyclooxygenase in visceral nociception.
    The Journal of pharmacology and experimental therapeutics, 2009, Volume: 329, Issue:1

    Topics: Acetic Acid; Amidohydrolases; Animals; Benzamides; Carbamates; Cyclooxygenase Inhibitors; Diclofenac; Dose-Response Relationship, Drug; Drug Synergism; Enzyme Inhibitors; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Naltrexone; Narcotic Antagonists; Nociceptors; Pain; Protective Agents; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Stomach Ulcer

2009
Long-term consequences of URB597 administration during adolescence on cannabinoid CB1 receptor binding in brain areas.
    Brain research, 2009, Feb-27, Volume: 1257

    Topics: Aging; Analysis of Variance; Animals; Arachidonic Acids; Autoradiography; Benzamides; Brain; Carbamates; Endocannabinoids; Male; Polyunsaturated Alkamides; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1

2009
Acute hypertension reveals depressor and vasodilator effects of cannabinoids in conscious rats.
    British journal of pharmacology, 2009, Volume: 156, Issue:1

    Topics: Acute Disease; Amidohydrolases; Animals; Arachidonic Acids; Benzamides; Benzoxazines; Blood Pressure; Cannabinoids; Carbamates; Consciousness; Endocannabinoids; Hindlimb; Hypertension; Infusions, Intravenous; Injections, Intravenous; Male; Morpholines; Naphthalenes; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Renal Circulation; Splanchnic Circulation; Vascular Resistance; Vasodilation

2009
Pore dilation occurs in TRPA1 but not in TRPM8 channels.
    Molecular pain, 2009, Jan-21, Volume: 5

    Topics: Aldehydes; Allyl Compounds; Anesthetics, Local; Animals; Benzamides; Benzoxazoles; Calcium; Calcium Channel Blockers; Calcium Channels; Calcium Signaling; Carbamates; Cells, Cultured; HeLa Cells; Humans; Ion Channel Gating; Lidocaine; Membrane Potentials; Movement; Nerve Tissue Proteins; Porins; Quinolinium Compounds; Rats; Thiocyanates; Transient Receptor Potential Channels; TRPA1 Cation Channel; TRPM Cation Channels

2009
Endocannabinoid modulation of scratching response in an acute allergenic model: a new prospective neural therapeutic target for pruritus.
    The Journal of pharmacology and experimental therapeutics, 2009, Volume: 329, Issue:1

    Topics: Amidohydrolases; Animals; Antipruritics; Behavior, Animal; Benzamides; Cannabinoid Receptor Modulators; Carbamates; Cell Degranulation; Dermatitis, Contact; Dose-Response Relationship, Drug; Dronabinol; Endocannabinoids; Enzyme Inhibitors; Genotype; Mast Cells; Mice; Mice, Inbred C57BL; Mice, Inbred ICR; p-Methoxy-N-methylphenethylamine; Pruritus; Pyridines; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Receptors, Cannabinoid

2009
The FAAH inhibitor URB-597 interferes with cisplatin- and nicotine-induced vomiting in the Suncus murinus (house musk shrew).
    Physiology & behavior, 2009, Apr-20, Volume: 97, Issue:1

    Topics: Amidohydrolases; Animals; Arachidonic Acids; Benzamides; Carbamates; Cisplatin; Drug Interactions; Endocannabinoids; Female; Male; Nicotine; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant; Shrews; Vomiting

2009
Interactions between environmental aversiveness and the anxiolytic effects of enhanced cannabinoid signaling by FAAH inhibition in rats.
    Psychopharmacology, 2009, Volume: 204, Issue:4

    Topics: Amidohydrolases; Animals; Anti-Anxiety Agents; Anxiety; Benzamides; Carbamates; Chlordiazepoxide; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme Inhibitors; Male; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Signal Transduction

2009
Processing cardiovascular information in the vlPAG during electroacupuncture in rats: roles of endocannabinoids and GABA.
    Journal of applied physiology (Bethesda, Md. : 1985), 2009, Volume: 106, Issue:6

    Topics: Animals; Benzamides; Cannabinoid Receptor Modulators; Carbamates; Drug Antagonism; Electroacupuncture; Endocannabinoids; gamma-Aminobutyric Acid; Hemodynamics; Male; Periaqueductal Gray; Piperidines; Pyrazoles; Pyridazines; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Reflex; Stomach; Sympathetic Nervous System

2009
Depolarizing GABAergic synaptic input triggers endocannabinoid-mediated retrograde synaptic signaling.
    Synapse (New York, N.Y.), 2009, Volume: 63, Issue:8

    Topics: Aniline Compounds; Animals; Animals, Newborn; Arachidonic Acids; Benzamides; Bicuculline; Biophysics; Calcium; Calcium Signaling; Cannabinoid Receptor Antagonists; Cannabinoid Receptor Modulators; Carbamates; Cerebellum; Electric Stimulation; Endocannabinoids; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Fluoresceins; GABA Agonists; GABA Antagonists; gamma-Aminobutyric Acid; Glycerides; In Vitro Techniques; Inhibitory Postsynaptic Potentials; Lactones; Mice; Muscimol; Orlistat; Patch-Clamp Techniques; Piperidines; Purkinje Cells; Pyrazoles; Quinoxalines; Rimonabant; Signal Transduction; Synapses; Valine

2009
Fatty acid amide hydrolase (FAAH) inhibition enhances memory acquisition through activation of PPAR-alpha nuclear receptors.
    Learning & memory (Cold Spring Harbor, N.Y.), 2009, Volume: 16, Issue:5

    Topics: Amidohydrolases; Animals; Benzamides; Brain; Carbamates; Enzyme Inhibitors; Learning; Male; Memory; PPAR alpha; Pyrimidines; Rats; Rats, Sprague-Dawley; Receptors, Cytoplasmic and Nuclear

2009
Inhibitors of endocannabinoid-metabolizing enzymes reduce precipitated withdrawal responses in THC-dependent mice.
    The AAPS journal, 2009, Volume: 11, Issue:2

    Topics: Amidohydrolases; Animals; Benzamides; Benzodioxoles; Cannabinoid Receptor Modulators; Carbamates; Dronabinol; Endocannabinoids; Enzyme Inhibitors; Hallucinogens; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Monoacylglycerol Lipases; Motor Activity; Piperidines; Postural Balance; Psychomotor Performance; Pyrazoles; Rimonabant; Substance Withdrawal Syndrome

2009
The endocannabinoid anandamide is a precursor for the signaling lipid N-arachidonoyl glycine by two distinct pathways.
    BMC biochemistry, 2009, May-21, Volume: 10

    Topics: Amidohydrolases; Animals; Arachidonic Acids; Benzamides; Brain; Brain Chemistry; Carbamates; Cell Line, Tumor; Endocannabinoids; Glycine; Lipid Metabolism; Male; Metabolic Networks and Pathways; Mice; Mice, Knockout; Oxidation-Reduction; Polyunsaturated Alkamides; Rats; Recombinant Proteins

2009
Screening of various hormone-sensitive lipase inhibitors as endocannabinoid-hydrolyzing enzyme inhibitors.
    ChemMedChem, 2009, Volume: 4, Issue:8

    Topics: Amidohydrolases; Animals; Benzamides; Binding Sites; Carbamates; Computer Simulation; Crystallography, X-Ray; Drug Design; Enzyme Inhibitors; Hydrolysis; Mice; Monoacylglycerol Lipases; Oxadiazoles; Sterol Esterase; Structure-Activity Relationship

2009
Inhibition of fatty acid amide hydrolase reduces reinstatement of nicotine seeking but not break point for nicotine self-administration--comparison with CB(1) receptor blockade.
    Psychopharmacology, 2009, Volume: 205, Issue:4

    Topics: Amidohydrolases; Animals; Behavior, Addictive; Benzamides; Carbamates; Enzyme Inhibitors; Male; Nicotine; Piperidines; Pyrazoles; Rats; Rats, Long-Evans; Receptor, Cannabinoid, CB1; Rimonabant; Self Administration; Smoking

2009
Blockade of endocannabinoid-degrading enzymes attenuates neuropathic pain.
    The Journal of pharmacology and experimental therapeutics, 2009, Volume: 330, Issue:3

    Topics: Amidohydrolases; Analgesics, Non-Narcotic; Animals; Arachidonic Acids; Benzamides; Benzodioxoles; Cannabinoid Receptor Modulators; Carbamates; Cold Temperature; Endocannabinoids; Enzyme Inhibitors; Glycerides; Hyperalgesia; Male; Mice; Mice, Inbred C57BL; Monoacylglycerol Lipases; Narcotic Antagonists; Pain; Pain Measurement; Peripheral Nervous System Diseases; Piperidines; Polyunsaturated Alkamides; Pyridines; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; TRPV Cation Channels

2009
URB597, an inhibitor of fatty acid amide hydrolase, reduces hyperalgesia in diabetic rats.
    Canadian journal of physiology and pharmacology, 2009, Volume: 87, Issue:6

    Topics: Amidohydrolases; Animals; Benzamides; Blood Glucose; Body Weight; Cannabinoid Receptor Modulators; Carbamates; Diabetes Mellitus, Experimental; Dose-Response Relationship, Drug; Enzyme Inhibitors; Hyperalgesia; Injections, Intraperitoneal; Male; Pain Measurement; Pain Threshold; Rats; Rats, Wistar; Temperature

2009
Anandamide increases the differentiation of rat adipocytes and causes PPARgamma and CB1 receptor upregulation.
    Obesity (Silver Spring, Md.), 2009, Volume: 17, Issue:10

    Topics: Adipocytes; Adipose Tissue; Amidohydrolases; Animals; Arachidonic Acids; Benzamides; Blotting, Western; Carbamates; Cell Differentiation; Cyclooxygenase 2; Endocannabinoids; Enzyme Inhibitors; Flow Cytometry; Indomethacin; Male; Polyunsaturated Alkamides; PPAR gamma; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Reverse Transcriptase Polymerase Chain Reaction; Up-Regulation

2009
Cannabinoids and their interactions with diazepam on modulation of serum corticosterone concentration in male mice.
    Neurochemical research, 2010, Volume: 35, Issue:1

    Topics: Animals; Arachidonic Acids; Benzamides; Benzoxazines; Cannabinoid Receptor Antagonists; Cannabinoids; Carbamates; Corticosterone; Diazepam; Drug Interactions; Enzyme-Linked Immunosorbent Assay; Male; Mice; Morpholines; Naphthalenes

2010
Endocannabinoid modulation of amphetamine sensitization is disrupted in a rodent model of lesion-induced dopamine dysregulation.
    Synapse (New York, N.Y.), 2009, Volume: 63, Issue:11

    Topics: Amidohydrolases; Amphetamine; Animals; Benzamides; Cannabinoid Receptor Modulators; Carbamates; Central Nervous System Stimulants; Dopamine; Endocannabinoids; Enzyme Inhibitors; Exploratory Behavior; Male; Motor Activity; Olfactory Bulb; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1

2009
Inhibition of fatty-acid amide hydrolase and CB1 receptor antagonism differentially affect behavioural responses in normal and PCP-treated rats.
    The international journal of neuropsychopharmacology, 2010, Volume: 13, Issue:3

    Topics: Amidohydrolases; Amphetamine; Animals; Autoradiography; Behavior, Animal; Benzamides; Cannabinoid Receptor Modulators; Carbamates; Central Nervous System Stimulants; Cyclohexanols; Drug Administration Schedule; Drug Interactions; Enzyme Inhibitors; Guanosine 5'-O-(3-Thiotriphosphate); Hallucinogens; Interpersonal Relations; Male; Memory, Short-Term; Motor Activity; Neuropsychological Tests; Phencyclidine; Piperidines; Protein Binding; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Statistics, Nonparametric; Sulfur Isotopes; Time Factors

2010
Role of endocannabinoid system in the ventral hippocampus of rats in the modulation of anxiety-like behaviours.
    Basic & clinical pharmacology & toxicology, 2009, Volume: 105, Issue:5

    Topics: Amidohydrolases; Animals; Anxiety; Baclofen; Behavior, Animal; Benzamides; Bicuculline; Cannabinoid Receptor Modulators; Carbamates; Dose-Response Relationship, Drug; Endocannabinoids; GABA Antagonists; Hippocampus; Male; Maze Learning; Piperidines; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1

2009
Blockade of 2-arachidonoylglycerol hydrolysis by selective monoacylglycerol lipase inhibitor 4-nitrophenyl 4-(dibenzo[d][1,3]dioxol-5-yl(hydroxy)methyl)piperidine-1-carboxylate (JZL184) Enhances retrograde endocannabinoid signaling.
    The Journal of pharmacology and experimental therapeutics, 2009, Volume: 331, Issue:2

    Topics: Amidohydrolases; Animals; Arachidonic Acids; Benzamides; Benzodioxoles; Cannabinoid Receptor Modulators; Carbamates; Electrophysiology; Endocannabinoids; Enzyme Inhibitors; Glycerides; Hydrolysis; Lipase; Mice; Mice, Inbred C57BL; Mice, Knockout; Patch-Clamp Techniques; Piperidines; Purkinje Cells; Pyramidal Cells; Rats; Rats, Sprague-Dawley; Signal Transduction; Synapses

2009
FAAH inhibitor, URB-597, promotes extinction and CB(1) antagonist, SR141716, inhibits extinction of conditioned aversion produced by naloxone-precipitated morphine withdrawal, but not extinction of conditioned preference produced by morphine in rats.
    Pharmacology, biochemistry, and behavior, 2009, Volume: 94, Issue:1

    Topics: Amidohydrolases; Animals; Benzamides; Cannabinoid Receptor Modulators; Carbamates; Choice Behavior; Conditioning, Psychological; Dietary Sucrose; Extinction, Psychological; Female; Injections, Intraperitoneal; Injections, Subcutaneous; Male; Morphine; Morphine Dependence; Naloxone; Narcotic Antagonists; Narcotics; Piperidines; Pyrazoles; Rats; Rats, Long-Evans; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Reinforcement Schedule; Rimonabant; Species Specificity; Substance Withdrawal Syndrome

2009
Suppression of amygdalar endocannabinoid signaling by stress contributes to activation of the hypothalamic-pituitary-adrenal axis.
    Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2009, Volume: 34, Issue:13

    Topics: Amidohydrolases; Amygdala; Animals; Arachidonic Acids; Benzamides; Cannabinoid Receptor Modulators; Carbamates; Corticosterone; Dronabinol; Drug Interactions; Endocannabinoids; Hypothalamo-Hypophyseal System; Male; Microinjections; Piperidines; Pituitary-Adrenal System; Polyunsaturated Alkamides; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Restraint, Physical; Signal Transduction; Stress, Psychological

2009
Effect of nitric oxide donors on membrane tritium accumulation of endocannabinoids and related endogenous lipids.
    European journal of pharmacology, 2009, Oct-25, Volume: 621, Issue:1-3

    Topics: Amides; Animals; Arachidonic Acids; Benzamides; Cannabinoid Receptor Modulators; Carbamates; Cell Line; Cell Membrane; Cyclic N-Oxides; Endocannabinoids; Ethanolamines; Free Radical Scavengers; Glycerides; Imidazoles; Lipid Metabolism; Mice; Nitric Oxide; Nitric Oxide Donors; Palmitic Acids; Polyunsaturated Alkamides; Rats; Signal Transduction; Tritium

2009
Metabolism of 2-acylglycerol in rabbit and human platelets. Involvement of monoacylglycerol lipase and fatty acid amide hydrolase.
    Platelets, 2009, Volume: 20, Issue:6

    Topics: Amidohydrolases; Animals; Arachidonic Acids; Benzamides; Blood Platelets; Carbamates; Endocannabinoids; Enzyme Inhibitors; Glycerides; Glycerol; Humans; Hydrogen-Ion Concentration; Hydrolysis; Immunoblotting; Monoacylglycerol Lipases; Palmitates; Rabbits; Subcellular Fractions; Tritium

2009
The effects of fatty acid amide hydrolase inhibitors on maintenance of cocaine and food self-administration and on reinstatement of cocaine-seeking and food-taking behavior in rats.
    Journal of physiology and pharmacology : an official journal of the Polish Physiological Society, 2009, Volume: 60, Issue:3

    Topics: Amidohydrolases; Animals; Behavior, Animal; Benzamides; Carbamates; Cocaine; Cocaine-Related Disorders; Consummatory Behavior; Dose-Response Relationship, Drug; Eating; Enzyme Inhibitors; Extinction, Psychological; Feeding Behavior; Injections, Intraperitoneal; Male; Phenylmethylsulfonyl Fluoride; Rats; Rats, Wistar; Reinforcement, Psychology; Self Administration

2009
The endogenous cannabinoid, anandamide, inhibits dopamine transporter function by a receptor-independent mechanism.
    Journal of neurochemistry, 2010, Volume: 112, Issue:6

    Topics: Alanine; Arachidonic Acids; Benzamides; Calcium; Cannabinoid Receptor Modulators; Carbamates; Cell Line, Transformed; Dopamine Plasma Membrane Transport Proteins; Dose-Response Relationship, Drug; Endocannabinoids; Enzyme Inhibitors; Humans; Luminescent Proteins; Microscopy, Confocal; Phenylmethylsulfonyl Fluoride; Polyunsaturated Alkamides; Receptors, Cannabinoid; Receptors, Scavenger; Silicone Elastomers; Time Factors; Transfection; Tritium; Tropanes

2010
The dual fatty acid amide hydrolase/TRPV1 blocker, N-arachidonoyl-serotonin, relieves carrageenan-induced inflammation and hyperalgesia in mice.
    Pharmacological research, 2010, Volume: 61, Issue:6

    Topics: Amidohydrolases; Analgesics; Animals; Anti-Inflammatory Agents; Arachidonic Acids; Benzamides; Capsaicin; Carbamates; Carrageenan; Hyperalgesia; Inflammation; Mice; Receptor, Cannabinoid, CB1; Serotonin; TRPV Cation Channels

2010
The hypothalamic endocannabinoid system participates in the secretion of oxytocin and tumor necrosis factor-alpha induced by lipopolysaccharide.
    Journal of neuroimmunology, 2010, Apr-15, Volume: 221, Issue:1-2

    Topics: Analysis of Variance; Animals; Arachidonic Acids; Benzamides; Cannabinoid Receptor Modulators; Carbamates; Endocannabinoids; Enzyme-Linked Immunosorbent Assay; Gene Expression Regulation; Hypothalamus; Indoles; Lipopolysaccharides; Male; Nitric Oxide; Oxytocin; Polyunsaturated Alkamides; Radioimmunoassay; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Tumor Necrosis Factor-alpha

2010
Transient receptor potential vanilloid 1 channels control acetylcholine/2-arachidonoylglicerol coupling in the striatum.
    Neuroscience, 2010, May-19, Volume: 167, Issue:3

    Topics: Acetylcholine; Amidohydrolases; Animals; Arachidonic Acids; Benzamides; Cannabinoid Receptor Modulators; Capsaicin; Carbamates; Corpus Striatum; Endocannabinoids; Enzyme Inhibitors; gamma-Aminobutyric Acid; Glycerides; Inhibitory Postsynaptic Potentials; Mice; Mice, Inbred C57BL; Mice, Knockout; Muscarinic Agonists; Neural Inhibition; Organ Culture Techniques; Polyunsaturated Alkamides; Receptor, Metabotropic Glutamate 5; Receptor, Muscarinic M1; Receptors, Metabotropic Glutamate; Sensory System Agents; Synaptic Transmission; TRPV Cation Channels

2010
Regulation of subthalamic neuron activity by endocannabinoids.
    Synapse (New York, N.Y.), 2010, Volume: 64, Issue:9

    Topics: Animals; Arachidonic Acids; Benzamides; Cannabinoid Receptor Modulators; Carbamates; Cerebral Cortex; Dose-Response Relationship, Drug; Dronabinol; Electrophysiology; Endocannabinoids; Globus Pallidus; Immunohistochemistry; Injections, Intraventricular; Male; Microinjections; Neurons; Piperidines; Polyunsaturated Alkamides; Prefrontal Cortex; Pyrazoles; Rats; Rats, Sprague-Dawley; Rimonabant; Subthalamic Nucleus

2010
Reduction in endocannabinoid tone is a homeostatic mechanism for specific inhibitory synapses.
    Nature neuroscience, 2010, Volume: 13, Issue:5

    Topics: Agatoxins; Animals; Arachidonic Acids; Benzamides; Benzoxazines; Biophysics; Calcium; Calcium Channel Blockers; Cannabinoid Receptor Modulators; Carbamates; Conotoxins; Dose-Response Relationship, Drug; Down-Regulation; Drug Interactions; Electric Stimulation; Endocannabinoids; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; gamma-Aminobutyric Acid; Glycerides; Hippocampus; Homeostasis; In Vitro Techniques; Inhibitory Postsynaptic Potentials; Morpholines; Naphthalenes; Nerve Net; Neural Inhibition; Neurons; Patch-Clamp Techniques; Piperidines; Polyamines; Polyunsaturated Alkamides; Pyrazoles; Rats; Receptor, Cannabinoid, CB1; Rimonabant; Sodium Channel Blockers; Synapses; Tetrodotoxin

2010
Inhibitors of monoacylglycerol lipase, fatty-acid amide hydrolase and endocannabinoid transport differentially suppress capsaicin-induced behavioral sensitization through peripheral endocannabinoid mechanisms.
    Pharmacological research, 2010, Volume: 62, Issue:3

    Topics: Amidohydrolases; Animals; Arachidonic Acids; Behavior, Animal; Benzamides; Benzodioxoles; Biological Transport; Cannabinoid Receptor Modulators; Capsaicin; Carbamates; Endocannabinoids; Male; Monoacylglycerol Lipases; Piperidines; Rats; Rats, Sprague-Dawley; Sensory System Agents

2010
Endogenous cannabinoid signaling is essential for stress adaptation.
    Proceedings of the National Academy of Sciences of the United States of America, 2010, May-18, Volume: 107, Issue:20

    Topics: Adaptation, Physiological; Analysis of Variance; Animals; Arachidonic Acids; Benzamides; Cannabinoid Receptor Modulators; Carbamates; Corticosterone; Endocannabinoids; Male; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Signal Transduction; Stress, Physiological

2010
Dynamic changes in the TRPA1 selectivity filter lead to progressive but reversible pore dilation.
    American journal of physiology. Cell physiology, 2010, Volume: 298, Issue:6

    Topics: Animals; Benzamides; Benzoxazoles; Calcium; Calcium Channels; Carbamates; Cell Membrane; Cell Membrane Permeability; CHO Cells; Cricetinae; Cricetulus; Dogs; Dose-Response Relationship, Drug; Farnesol; Humans; Ion Channel Gating; Isothiocyanates; Kinetics; Meglumine; Membrane Transport Modulators; Nerve Tissue Proteins; Purinergic P2 Receptor Agonists; Quinolinium Compounds; Rats; Receptors, Purinergic P2; Receptors, Purinergic P2X7; Salicylates; Transfection; Transient Receptor Potential Channels; TRPA1 Cation Channel; TRPM Cation Channels; TRPV Cation Channels

2010
Effects of fatty acid amide hydrolase inhibition on neuronal responses to nicotine, cocaine and morphine in the nucleus accumbens shell and ventral tegmental area: involvement of PPAR-alpha nuclear receptors.
    Addiction biology, 2010, Volume: 15, Issue:3

    Topics: Amidohydrolases; Animals; Benzamides; Carbamates; Cocaine; Dopamine; Evoked Potentials; Male; Morphine; Neurons; Nicotine; Nucleus Accumbens; PPAR alpha; Rats; Rats, Sprague-Dawley; Receptors, Cytoplasmic and Nuclear; Reward; Ventral Tegmental Area

2010
Crystal structure of fatty acid amide hydrolase bound to the carbamate inhibitor URB597: discovery of a deacylating water molecule and insight into enzyme inactivation.
    Journal of molecular biology, 2010, Jul-23, Volume: 400, Issue:4

    Topics: Amidohydrolases; Benzamides; Carbamates; Catalytic Domain; Crystallography, X-Ray; Enzyme Inhibitors; Models, Molecular; Protein Binding; Protein Structure, Tertiary; Water

2010
Genetic deletion of fatty acid amide hydrolase alters emotional behavior and serotonergic transmission in the dorsal raphe, prefrontal cortex, and hippocampus.
    Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2010, Volume: 35, Issue:10

    Topics: Action Potentials; Amidohydrolases; Animals; Behavior, Animal; Benzamides; Brain; Cannabinoid Receptor Antagonists; Carbamates; Enzyme Inhibitors; Exploratory Behavior; Hindlimb Suspension; Hippocampus; Male; Maze Learning; Mice; Mice, Inbred C57BL; Mice, Knockout; Mood Disorders; Piperidines; Prefrontal Cortex; Pyrazoles; Raphe Nuclei; Rimonabant; Serotonin; Serotonin Agents; Swimming

2010
Biochanin A, a naturally occurring inhibitor of fatty acid amide hydrolase.
    British journal of pharmacology, 2010, Volume: 160, Issue:3

    Topics: Amidohydrolases; Animals; Arachidonic Acids; Behavior, Animal; Benzamides; Brain; Cannabinoid Receptor Antagonists; Carbamates; Cell Line, Transformed; Chlorocebus aethiops; COS Cells; Drug Interactions; Endocannabinoids; Extracellular Signal-Regulated MAP Kinases; Formaldehyde; Genistein; Humans; Isoflavones; Liver; Mice; Mice, Inbred ICR; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rats

2010
PET imaging of fatty acid amide hydrolase in the brain: synthesis and biological evaluation of an 11C-labelled URB597 analogue.
    Nuclear medicine and biology, 2010, Volume: 37, Issue:5

    Topics: Amidohydrolases; Animals; Benzamides; Brain; Carbamates; Carbon Radioisotopes; Gene Knockout Techniques; Humans; Male; Mice; Positron-Emission Tomography; Quality Control

2010
Reducing endocannabinoid metabolism with the fatty acid amide hydrolase inhibitor, URB597, fails to modify reinstatement of morphine-induced conditioned floor preference and naloxone-precipitated morphine withdrawal-induced conditioned floor avoidance.
    Pharmacology, biochemistry, and behavior, 2010, Volume: 96, Issue:4

    Topics: Amidohydrolases; Animals; Avoidance Learning; Benzamides; Cannabinoid Receptor Modulators; Carbamates; Conditioning, Classical; Endocannabinoids; Enzyme Inhibitors; Male; Morphine; Naloxone; Rats; Rats, Sprague-Dawley; Substance Withdrawal Syndrome

2010
Cannabinoid-induced reduction in antral pacemaker frequency: a telemetric study in the ferret.
    Neurogastroenterology and motility, 2010, Volume: 22, Issue:11

    Topics: Amidohydrolases; Animals; Apomorphine; Benzamides; Biological Clocks; Body Temperature; Cannabinoids; Carbamates; Emetics; Female; Ferrets; Heart Rate; Myoelectric Complex, Migrating; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Telemetry; Vomiting

2010
Effects of URB597, an inhibitor of fatty acid amide hydrolase (FAAH), on analgesic activity of paracetamol.
    Neuro endocrinology letters, 2010, Volume: 31, Issue:4

    Topics: Acetaminophen; Amidohydrolases; Analgesics, Non-Narcotic; Animals; Benzamides; Carbamates; Dose-Response Relationship, Drug; Drug Interactions; Linear Models; Male; Mice; Pain Measurement

2010
Hydrolysis of 2-arachidonoylglycerol in Tetrahymena thermophila. Identification and partial characterization of a Monoacylglycerol Lipase-like enzyme.
    European journal of protistology, 2010, Volume: 46, Issue:4

    Topics: Amidohydrolases; Arachidonic Acids; Benzamides; Carbamates; Cell Membrane; Cytosol; Endocannabinoids; Enzyme Inhibitors; Glycerides; Hydrogen-Ion Concentration; Hydrolysis; Kinetics; Molecular Weight; Monoacylglycerol Lipases; Palmitates; Protozoan Proteins; Tetrahymena thermophila

2010
Ethanolamine is a novel STAT-3 dependent cardioprotective agent.
    Basic research in cardiology, 2010, Volume: 105, Issue:6

    Topics: Amidohydrolases; Animals; Benzamides; Carbamates; Cardiovascular Agents; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme Inhibitors; Ethanolamine; Janus Kinases; Lysophospholipids; Male; Mice; Mice, Knockout; Myocardial Infarction; Myocardial Reperfusion Injury; Myocardium; Phosphorylation; Rats; Rats, Wistar; Sphingosine; STAT3 Transcription Factor; Tyrphostins

2010
Fatty acid amide hydrolase (FAAH) inhibition reduces L-3,4-dihydroxyphenylalanine-induced hyperactivity in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-lesioned non-human primate model of Parkinson's disease.
    The Journal of pharmacology and experimental therapeutics, 2011, Volume: 336, Issue:2

    Topics: Amides; Amidohydrolases; Animals; Benzamides; Callithrix; Carbamates; Disease Models, Animal; Dyskinesia, Drug-Induced; Endocannabinoids; Enzyme Inhibitors; Ethanolamines; Female; Levodopa; Motor Activity; MPTP Poisoning; Oleic Acids; Palmitic Acids; Psychoses, Substance-Induced

2011
Facilitation of CB1 receptor-mediated neurotransmission decreases marble burying behavior in mice.
    Progress in neuro-psychopharmacology & biological psychiatry, 2011, Mar-30, Volume: 35, Issue:2

    Topics: Amidohydrolases; Animals; Arachidonic Acids; Behavior, Animal; Benzamides; Benzoxazines; Calcium Channel Blockers; Cannabinoids; Carbamates; Drug Interactions; Endocannabinoids; Male; Mice; Mice, Inbred C57BL; Morpholines; Motor Activity; Naphthalenes; Obsessive-Compulsive Disorder; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Receptor, Cannabinoid, CB1; Synaptic Transmission

2011
Local application of the endocannabinoid hydrolysis inhibitor URB597 reduces nociception in spontaneous and chemically induced models of osteoarthritis.
    Pain, 2011, Volume: 152, Issue:5

    Topics: Action Potentials; Afferent Pathways; Age Factors; Animals; Arthralgia; Benzamides; Carbamates; Diclofenac; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme Inhibitors; Guinea Pigs; Indoles; Iodoacetic Acid; Male; Nociceptors; Osteoarthritis; Piperidines; Pyrazoles; Rats; Rats, Wistar; Time Factors; Weight-Bearing

2011
The blockade of the transient receptor potential vanilloid type 1 and fatty acid amide hydrolase decreases symptoms and central sequelae in the medial prefrontal cortex of neuropathic rats.
    Molecular pain, 2011, Jan-17, Volume: 7

    Topics: Amidohydrolases; Amygdala; Animals; Arachidonic Acids; Benzamides; Carbamates; Electric Stimulation; Electrodes; Electrophysiological Phenomena; Male; Microdialysis; Microinjections; Mononeuropathies; Neurons; Nociceptors; Piperidines; Prefrontal Cortex; Pyrazoles; Rats; Rats, Wistar; RNA, Messenger; Serotonin; TRPV Cation Channels

2011
Cannabinoid receptor activation modifies NMDA receptor mediated release of intracellular calcium: implications for endocannabinoid control of hippocampal neural plasticity.
    Neuropharmacology, 2011, Volume: 60, Issue:6

    Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Arachidonic Acids; Benzamides; Benzoxazines; Calcium; Cannabinoid Receptor Modulators; Carbamates; Endocannabinoids; Glycine; Hippocampus; In Vitro Techniques; Morpholines; Naphthalenes; Neuronal Plasticity; Neurons; Phosphorylation; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Receptors, N-Methyl-D-Aspartate; Rimonabant; Ryanodine Receptor Calcium Release Channel; Second Messenger Systems

2011
A FAAH-fetched approach to treat osteoarthritis pain.
    Pain, 2011, Volume: 152, Issue:5

    Topics: Amidohydrolases; Animals; Benzamides; Carbamates; Enzyme Inhibitors; Osteoarthritis; Pain

2011
Inhibition of fatty acid amide hydrolase modulates anxiety-like behavior in PCP-treated rats.
    Pharmacology, biochemistry, and behavior, 2011, Volume: 98, Issue:4

    Topics: Amidohydrolases; Animals; Anti-Anxiety Agents; Anxiety; Behavior, Animal; Benzamides; Carbamates; Enzyme Inhibitors; Male; Phencyclidine; Piperidines; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1

2011
The fatty acid amide hydrolase inhibitor URB 597: interactions with anandamide in rhesus monkeys.
    British journal of pharmacology, 2011, Volume: 164, Issue:2b

    Topics: Amidohydrolases; Animals; Arachidonic Acids; Benzamides; Carbamates; Discrimination, Psychological; Dronabinol; Drug Interactions; Drug Therapy, Combination; Endocannabinoids; Female; Macaca mulatta; Male; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rimonabant

2011
Disruptive effects of the prototypical cannabinoid Δ⁹-tetrahydrocannabinol and the fatty acid amide inhibitor URB-597 on go/no-go auditory discrimination performance and olfactory reversal learning in rats.
    Behavioural pharmacology, 2011, Volume: 22, Issue:3

    Topics: Animals; Benzamides; Carbamates; Discrimination Learning; Dronabinol; Hearing; Male; Piperidines; Pyrazoles; Rats; Rats, Wistar; Reversal Learning; Rimonabant; Smell

2011
Modulation of anticonvulsant effects of cannabinoid compounds by GABA-A receptor agonist in acute pentylenetetrazole model of seizure in rat.
    Neurochemical research, 2011, Volume: 36, Issue:8

    Topics: Animals; Anticonvulsants; Benzamides; Benzoxazines; Biphenyl Compounds; Brain; Calcium Channel Blockers; Cannabinoids; Carbamates; GABA Antagonists; GABA-A Receptor Agonists; Isonicotinic Acids; Male; Morpholines; Naphthalenes; Pentylenetetrazole; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Seizures

2011
Involvement of endocannabinoids in antidepressant and anti-compulsive effect of fluoxetine in mice.
    Behavioural brain research, 2011, Sep-30, Volume: 223, Issue:1

    Topics: Animals; Antidepressive Agents; Arachidonic Acids; Benzamides; Cannabinoid Receptor Modulators; Carbamates; Compulsive Behavior; Depression; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Drug Therapy, Combination; Endocannabinoids; Fluoxetine; Injections, Intraventricular; Male; Mice; Motor Activity; Piperidines; Polyunsaturated Alkamides; Pyrazoles

2011
Memory encoding in hippocampal ensembles is negatively influenced by cannabinoid CB1 receptors.
    Behavioural pharmacology, 2011, Volume: 22, Issue:4

    Topics: Action Potentials; Animals; Benzamides; Benzoxazines; Biphenyl Compounds; CA1 Region, Hippocampal; Cannabinoids; Carbamates; Electric Stimulation; Electrodes, Implanted; Hippocampus; Injections; Male; Memory; Morpholines; Naphthalenes; Neurons; Piperidines; Pyrazoles; Rats; Rats, Long-Evans; Receptor, Cannabinoid, CB1; Rimonabant

2011
The effect of anandamide on uterine nitric oxide synthase activity depends on the presence of the blastocyst.
    PloS one, 2011, Apr-29, Volume: 6, Issue:4

    Topics: Animals; Arachidonic Acids; Benzamides; Blastocyst; Cannabinoid Receptor Modulators; Carbamates; Embryo Implantation; Endocannabinoids; Female; Immunohistochemistry; Nitric Oxide Synthase; Polymerase Chain Reaction; Polyunsaturated Alkamides; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Uterus

2011
Targeting the endocannabinoid system in the amygdala kindling model of temporal lobe epilepsy in mice.
    Epilepsia, 2011, Volume: 52, Issue:7

    Topics: Amidohydrolases; Amygdala; Animals; Benzamides; Benzoxazines; Carbamates; Disease Models, Animal; Epilepsy, Temporal Lobe; Kindling, Neurologic; Male; Mice; Models, Neurological; Morpholines; Naphthalenes; Receptor, Cannabinoid, CB1; Seizures

2011
Differential role of anandamide and 2-arachidonoylglycerol in memory and anxiety-like responses.
    Biological psychiatry, 2011, Sep-01, Volume: 70, Issue:5

    Topics: Amidohydrolases; Analgesics; Animals; Anti-Anxiety Agents; Arachidonic Acids; Benzamides; Benzodioxoles; Cannabinoid Receptor Antagonists; Carbamates; Drug Tolerance; Endocannabinoids; Glycerides; Hippocampus; Maze Learning; Mice; Mice, Inbred Strains; Mice, Knockout; Monoacylglycerol Lipases; Pain Measurement; Piperidines; Polyunsaturated Alkamides; Receptors, Cannabinoid; Recognition, Psychology; TOR Serine-Threonine Kinases

2011
Fatty acid amide hydrolase blockade attenuates the development of collagen-induced arthritis and related thermal hyperalgesia in mice.
    Pharmacology, biochemistry, and behavior, 2011, Volume: 99, Issue:4

    Topics: Amidohydrolases; Animals; Arthritis, Experimental; Benzamides; Camphanes; Carbamates; Foot; Genotype; Hot Temperature; Hyperalgesia; Male; Mice; Mice, Inbred DBA; Mice, Knockout; Pain Measurement; Phenotype; Pyrazoles; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2

2011
Cannabinoids mediate opposing effects on inflammation-induced intestinal permeability.
    British journal of pharmacology, 2012, Volume: 165, Issue:8

    Topics: Amidohydrolases; Benzamides; Benzodioxoles; Caco-2 Cells; Cannabinoids; Carbamates; Cell Survival; Enzyme Inhibitors; Humans; Indoles; Inflammation; Interferon-gamma; Intestinal Mucosa; Monoacylglycerol Lipases; Permeability; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Tumor Necrosis Factor-alpha

2012
Behavioral effects of fatty acid amide hydrolase inhibition on morphine withdrawal symptoms.
    Brain research bulletin, 2011, Aug-10, Volume: 86, Issue:1-2

    Topics: Amidohydrolases; Animals; Behavior, Animal; Benzamides; Cannabinoid Receptor Modulators; Carbamates; Humans; Male; Morphine Dependence; Random Allocation; Rats; Rats, Wistar; Substance Withdrawal Syndrome

2011
Administration of URB597, oleoylethanolamide or palmitoylethanolamide increases waking and dopamine in rats.
    PloS one, 2011, Volume: 6, Issue:7

    Topics: Amides; Amidohydrolases; Animals; Benzamides; Carbamates; Dopamine; Endocannabinoids; Enzyme Inhibitors; Ethanolamines; Hypothalamus; Male; Oleic Acids; Palmitic Acids; Rats; Sleep; Wakefulness

2011
Fear-induced suppression of nociceptive behaviour and activation of Akt signalling in the rat periaqueductal grey: role of fatty acid amide hydrolase.
    Journal of psychopharmacology (Oxford, England), 2012, Volume: 26, Issue:1

    Topics: Amidohydrolases; Analgesia; Animals; Arachidonic Acids; Behavior, Animal; Benzamides; Cannabinoid Receptor Modulators; Carbamates; Conditioning, Psychological; Endocannabinoids; Ethanolamines; Exploratory Behavior; Fear; Formaldehyde; Hippocampus; Male; Motor Activity; Nociception; Pain; Periaqueductal Gray; Polyunsaturated Alkamides; Proto-Oncogene Proteins c-akt; Rats; Signal Transduction

2012
L-type calcium channel mediates anticonvulsant effect of cannabinoids in acute and chronic murine models of seizure.
    Neurochemical research, 2012, Volume: 37, Issue:2

    Topics: Acute Disease; Animals; Anticonvulsants; Benzamides; Benzoxazines; Calcium Channels, L-Type; Cannabinoids; Carbamates; Chronic Disease; Diltiazem; Disease Models, Animal; Kindling, Neurologic; Male; Mice; Morpholines; Naphthalenes; Rats; Rats, Wistar; Seizures; Verapamil

2012
Pharmacological inhibition of endocannabinoid degradation modulates the expression of inflammatory mediators in the hypothalamus following an immunological stressor.
    Neuroscience, 2012, Mar-01, Volume: 204

    Topics: Animals; Benzamides; Cannabinoid Receptor Modulators; Carbamates; Cytokines; Endocannabinoids; Hypothalamus; Inflammation Mediators; Lipopolysaccharides; Male; Rats; Rats, Sprague-Dawley; Stress, Physiological

2012
Inhibition of fatty acid amide hydrolase (FAAH) reduces spinal nociceptive responses and expression of spinal long-term potentiation (LTP).
    Brain research bulletin, 2012, Feb-10, Volume: 87, Issue:2-3

    Topics: Amidohydrolases; Animals; Benzamides; Biophysics; Carbamates; Dose-Response Relationship, Drug; Electric Stimulation; Enzyme Inhibitors; Female; Gene Expression Regulation; Long-Term Potentiation; Naloxone; Narcotic Antagonists; Nerve Fibers; Nociception; Rats; Rats, Sprague-Dawley; Spinal Cord; Time Factors

2012
Endocannabinoid regulation of acute and protracted nicotine withdrawal: effect of FAAH inhibition.
    PloS one, 2011, Volume: 6, Issue:11

    Topics: Acute Disease; Amidohydrolases; Animals; Anxiety; Arachidonic Acids; Benzamides; Brain; Cannabinoid Receptor Modulators; Carbamates; Cotinine; Endocannabinoids; Glycerides; Implants, Experimental; Locomotion; Male; Maze Learning; Nicotine; Polyunsaturated Alkamides; Rats; Rats, Wistar; Substance Withdrawal Syndrome; Tobacco Use Cessation Devices; Weight Gain

2011
Medial prefrontal cortex endocannabinoid system modulates baroreflex activity through CB(1) receptors.
    American journal of physiology. Regulatory, integrative and comparative physiology, 2012, Volume: 302, Issue:7

    Topics: Amidohydrolases; Animals; Arachidonic Acids; Baroreflex; Benzamides; Blood Pressure; Cannabinoid Receptor Modulators; Carbamates; Endocannabinoids; Glutamic Acid; Male; Piperidines; Prefrontal Cortex; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1

2012
SK channel modulation rescues striatal plasticity and control over habit in cannabinoid tolerance.
    Nature neuroscience, 2012, Jan-08, Volume: 15, Issue:2

    Topics: Animals; Apamin; Benzamides; Biophysics; Cannabinoids; Carbamates; Conditioning, Operant; Corpus Striatum; Cyclohexanols; Dose-Response Relationship, Drug; Dronabinol; Drug Tolerance; Electric Stimulation; Enzyme Inhibitors; Excitatory Postsynaptic Potentials; Guanosine 5'-O-(3-Thiotriphosphate); Habits; Long-Term Synaptic Depression; Male; Mice; Mice, Inbred C57BL; Motor Activity; Okadaic Acid; Patch-Clamp Techniques; Piperidines; Protein Binding; Pyrazoles; Rimonabant; Small-Conductance Calcium-Activated Potassium Channels; Sodium Channel Blockers; Tritium

2012
Endocannabinoid analogues exacerbate marble-burying behavior in mice via TRPV1 receptor.
    Neuropharmacology, 2012, Volume: 62, Issue:5-6

    Topics: Animals; Arachidonic Acids; Behavior, Animal; Benzamides; Cannabinoids; Carbamates; Endocannabinoids; Mice; Motor Activity; Polyunsaturated Alkamides; TRPV Cation Channels

2012
Vascular metabolism of anandamide to arachidonic acid affects myogenic constriction in response to intraluminal pressure elevation.
    Life sciences, 2012, Mar-10, Volume: 90, Issue:11-12

    Topics: Analysis of Variance; Animals; Arachidonic Acids; Arterioles; Benzamides; Benzoxazines; Blood Pressure; Caproates; Capsaicin; Carbamates; Dose-Response Relationship, Drug; Endocannabinoids; Flavanones; Immunohistochemistry; In Vitro Techniques; Indomethacin; Morpholines; Muscle Contraction; Muscle, Smooth, Vascular; Naphthalenes; Polyunsaturated Alkamides; Rats

2012
Prefrontal cortical anandamide signaling coordinates coping responses to stress through a serotonergic pathway.
    European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology, 2012, Volume: 22, Issue:9

    Topics: Action Potentials; Adaptation, Psychological; Animals; Arachidonic Acids; Benzamides; Cannabinoid Receptor Antagonists; Carbamates; Endocannabinoids; Enzyme Inhibitors; Fenclonine; Glycerides; Male; Microinjections; Piperidines; Polyunsaturated Alkamides; Prefrontal Cortex; Pyrazoles; Raphe Nuclei; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Serotonergic Neurons; Signal Transduction; Stress, Psychological

2012
Differences in spontaneously avoiding or approaching mice reflect differences in CB1-mediated signaling of dorsal striatal transmission.
    PloS one, 2012, Volume: 7, Issue:3

    Topics: Animals; Behavior, Animal; Benzamides; Carbamates; Corpus Striatum; Male; Maze Learning; Mice; Mice, Inbred C57BL; Neurons; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Signal Transduction; Synaptic Transmission

2012
Peripheral FAAH inhibition causes profound antinociception and protects against indomethacin-induced gastric lesions.
    Pharmacological research, 2012, Volume: 65, Issue:5

    Topics: Amidohydrolases; Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Benzamides; Cannabinoids; Carbamates; Disease Models, Animal; Enzyme Inhibitors; Hyperalgesia; Indomethacin; Male; Mice; Pain; Pyridazines; Sciatic Nerve; Stomach Ulcer; Urea

2012
The association of N-palmitoylethanolamine with the FAAH inhibitor URB597 impairs melanoma growth through a supra-additive action.
    BMC cancer, 2012, Mar-19, Volume: 12

    Topics: Amides; Animals; Arachidonic Acids; Benzamides; Cannabinoid Receptor Modulators; Carbamates; Cell Death; Cell Line, Tumor; Cell Survival; Disease Models, Animal; Drug Synergism; Endocannabinoids; Ethanolamines; Male; Mass Spectrometry; Melanoma, Experimental; Mice; Mice, Inbred C57BL; Palmitic Acids; Polyunsaturated Alkamides; Random Allocation; Reverse Transcriptase Polymerase Chain Reaction; Skin Neoplasms

2012
Enhanced vasorelaxant effects of the endocannabinoid-like mediator, oleamide, in hypertension.
    European journal of pharmacology, 2012, Jun-05, Volume: 684, Issue:1-3

    Topics: Amidohydrolases; Animals; Aorta; Benzamides; Biomimetic Materials; Cannabinoid Receptor Modulators; Capsaicin; Carbamates; Cyclooxygenase Inhibitors; Endocannabinoids; Endothelium, Vascular; Hypertension; In Vitro Techniques; Male; NG-Nitroarginine Methyl Ester; Oleic Acids; Rats; Receptor, Cannabinoid, CB1; TRPV Cation Channels; Vasodilator Agents

2012
Effects of alterations in cannabinoid signaling, alone and in combination with morphine, on pain-elicited and pain-suppressed behavior in mice.
    The Journal of pharmacology and experimental therapeutics, 2012, Volume: 342, Issue:1

    Topics: Amidohydrolases; Analgesics; Animals; Arachidonic Acids; Benzamides; Cannabinoid Receptor Modulators; Carbamates; Cyclohexanols; Endocannabinoids; Male; Mice; Mice, Inbred C57BL; Morphine; Nociception; Pain; Polyunsaturated Alkamides; Receptor, Cannabinoid, CB1

2012
The fatty acid amide hydrolase inhibitor URB597 exerts anti-inflammatory effects in hippocampus of aged rats and restores an age-related deficit in long-term potentiation.
    Journal of neuroinflammation, 2012, Apr-26, Volume: 9

    Topics: Aging; Amidohydrolases; Animals; Anti-Inflammatory Agents, Non-Steroidal; Benzamides; Carbamates; Hippocampus; Long-Term Potentiation; Male; Microglia; Rats; Rats, Wistar

2012
Cannabinoid type-1 receptor reduces pain and neurotoxicity produced by chemotherapy.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2012, May-16, Volume: 32, Issue:20

    Topics: Activating Transcription Factor 3; Animals; Antineoplastic Agents; Arachidonic Acids; Benzamides; Cannabinoid Receptor Modulators; Carbamates; Cells, Cultured; Cisplatin; Disease Models, Animal; Drug Interactions; Endocannabinoids; Enzyme Inhibitors; Ganglia, Spinal; Hyperalgesia; Male; Mice; Mice, Inbred C3H; Morpholines; Motor Activity; Neurites; Neurotoxicity Syndromes; Peripheral Nervous System Diseases; Polyunsaturated Alkamides; Pyrazoles; Receptor, Cannabinoid, CB1; TRPV Cation Channels

2012
Lack of effect of chronic pre-treatment with the FAAH inhibitor URB597 on inflammatory pain behaviour: evidence for plastic changes in the endocannabinoid system.
    British journal of pharmacology, 2012, Volume: 167, Issue:3

    Topics: Amides; Amidohydrolases; Animals; Arachidonic Acids; Behavior, Animal; Benzamides; Carbamates; Disease Models, Animal; Drug Administration Schedule; Endocannabinoids; Ethanolamines; Inflammation; Male; Oleic Acids; Pain; Palmitic Acids; Polyunsaturated Alkamides; Rats; Rats, Sprague-Dawley; Spinal Cord

2012
Dysfunction in fatty acid amide hydrolase is associated with depressive-like behavior in Wistar Kyoto rats.
    PloS one, 2012, Volume: 7, Issue:5

    Topics: Amidohydrolases; Animals; Arachidonic Acids; Benzamides; Brain; Brain-Derived Neurotrophic Factor; Cannabinoid Receptor Modulators; Carbamates; Depressive Disorder; Disease Models, Animal; Endocannabinoids; Enzyme Inhibitors; Frontal Lobe; Genetic Predisposition to Disease; Hippocampus; Male; Phospholipase D; Polyunsaturated Alkamides; Rats; Rats, Inbred WKY; Rats, Wistar; Receptor, Cannabinoid, CB1; Species Specificity; Swimming

2012
Endothelium-dependent mechanisms of the vasodilatory effect of the endocannabinoid, anandamide, in the rat pulmonary artery.
    Pharmacological research, 2012, Volume: 66, Issue:3

    Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Amidohydrolases; Animals; Anisoles; Apamin; Arachidonic Acids; Benzamides; Benzyl Compounds; Cannabinoid Receptor Antagonists; Capsaicin; Carbamates; Charybdotoxin; Cyclohexanes; Endocannabinoids; Endothelium, Vascular; Imidazoles; Indoles; Indomethacin; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Piperidines; Polyunsaturated Alkamides; Potassium Channel Blockers; Potassium Chloride; Prostaglandin-Endoperoxide Synthases; Pulmonary Artery; Pyrazoles; Rats; Rats, Wistar; Receptors, Cannabinoid; Receptors, Epoprostenol; Tetraethylammonium; TRPV Cation Channels; Vasodilation

2012
N-arachidonoyl-serotonin in the basolateral amygdala increases anxiolytic behavior in the elevated plus maze.
    Behavioural brain research, 2012, Aug-01, Volume: 233, Issue:2

    Topics: Amygdala; Analysis of Variance; Animals; Anxiety Disorders; Arachidonic Acids; Benzamides; Capsaicin; Carbamates; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Inhibitors; Exploratory Behavior; Male; Maze Learning; Rats; Rats, Sprague-Dawley; Serotonin; TRPV Cation Channels

2012
Hyperactivity induced by the dopamine D2/D3 receptor agonist quinpirole is attenuated by inhibitors of endocannabinoid degradation in mice.
    The international journal of neuropsychopharmacology, 2013, Volume: 16, Issue:3

    Topics: Animals; Benzamides; Carbamates; Dopamine Agonists; Endocannabinoids; Male; Mice; Mice, Inbred C57BL; Psychomotor Agitation; Quinpirole; Receptors, Dopamine D2; Receptors, Dopamine D3; Stereotyped Behavior

2013
Inhibition of fatty acid amide hydrolase by URB597 attenuates the anxiolytic-like effect of acetaminophen in the mouse elevated plus-maze test.
    Behavioural pharmacology, 2012, Volume: 23, Issue:4

    Topics: Acetaminophen; Amidohydrolases; Animals; Anti-Anxiety Agents; Anxiety; Arachidonic Acids; Benzamides; Carbamates; Disease Models, Animal; Dose-Response Relationship, Drug; Injections, Intraperitoneal; Male; Maze Learning; Mice; Mice, Inbred BALB C; Motor Activity; Piperidines; Pyrazoles; Rimonabant

2012
Prenatal stress and peripubertal stimulation of the endocannabinoid system differentially regulate emotional responses and brain metabolism in mice.
    PloS one, 2012, Volume: 7, Issue:7

    Topics: Anhedonia; Animals; Anxiety; Benzamides; Body Weight; Brain; Carbamates; Corticosterone; Drinking; Emotions; Endocannabinoids; Female; Locomotion; Male; Mice; Pregnancy; Puberty; Stress, Psychological; Time Factors

2012
The endocannabinoid, anandamide, augments Notch-1 signaling in cultured cortical neurons exposed to amyloid-β and in the cortex of aged rats.
    The Journal of biological chemistry, 2012, Oct-05, Volume: 287, Issue:41

    Topics: Aging; Alzheimer Disease; Amyloid beta-Peptides; Amyloid Precursor Protein Secretases; Animals; Arachidonic Acids; Benzamides; Carbamates; Cells, Cultured; Cerebral Cortex; Endocannabinoids; Gene Expression Regulation, Enzymologic; Glycerides; Hippocampus; Male; Membrane Glycoproteins; Neurons; Peptide Fragments; Polyunsaturated Alkamides; Rats; Rats, Wistar; Receptor, Notch1; Signal Transduction; Up-Regulation

2012
Covalent inhibition of recombinant human carboxylesterase 1 and 2 and monoacylglycerol lipase by the carbamates JZL184 and URB597.
    Biochemical pharmacology, 2012, Nov-01, Volume: 84, Issue:9

    Topics: Benzamides; Benzodioxoles; Carbamates; Carboxylesterase; Carboxylic Ester Hydrolases; Enzyme Reactivators; Hep G2 Cells; Humans; Kinetics; Monoacylglycerol Lipases; Paraoxon; Phosphorylation; Piperidines; Recombinant Proteins

2012
The FAAH inhibitor URB597 efficiently reduces tyrosine hydroxylase expression through CB₁- and FAAH-independent mechanisms.
    British journal of pharmacology, 2013, Volume: 169, Issue:4

    Topics: Amidohydrolases; Animals; Animals, Outbred Strains; Anti-Anxiety Agents; Antidepressive Agents; Benzamides; Cannabidiol; Cannabinoid Receptor Antagonists; Carbamates; Cell Line, Tumor; Corpus Striatum; Dopaminergic Neurons; Endocannabinoids; Enzyme Inhibitors; Gene Expression Regulation, Enzymologic; Genes, Reporter; Hippocampus; Mice; Nerve Tissue Proteins; Peroxisome Proliferator-Activated Receptors; Promoter Regions, Genetic; Receptor, Cannabinoid, CB1; Tyrosine 3-Monooxygenase

2013
Subventricular zone neural progenitors protect striatal neurons from glutamatergic excitotoxicity.
    Brain : a journal of neurology, 2012, Volume: 135, Issue:Pt 11

    Topics: 4-Aminopyridine; Amidohydrolases; Animals; Arachidonic Acids; Benzamides; Carbamates; Corpus Striatum; Disease Models, Animal; Dronabinol; Endocannabinoids; Epilepsy; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Ganciclovir; Glutamic Acid; Lateral Ventricles; Lipopolysaccharides; Mice; Mice, Inbred C57BL; Mice, Transgenic; Neural Stem Cells; Neuroprotective Agents; Polyunsaturated Alkamides; Stem Cells; Stroke

2012
Quantitative LC-MS/MS analysis of arachidonoyl amino acids in mouse brain with treatment of FAAH inhibitor.
    Analytical biochemistry, 2013, Jan-15, Volume: 432, Issue:2

    Topics: Amidohydrolases; Amino Acids; Animals; Arachidonic Acids; Benzamides; Brain; Carbamates; Chromatography, High Pressure Liquid; Endocannabinoids; Enzyme Inhibitors; gamma-Aminobutyric Acid; Glycerides; Mice; Polyunsaturated Alkamides; Tandem Mass Spectrometry

2013
Endocannabinoids in amygdala and nucleus accumbens mediate social play reward in adolescent rats.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2012, Oct-24, Volume: 32, Issue:43

    Topics: Amidohydrolases; Amygdala; Analysis of Variance; Animals; Animals, Newborn; Benzamides; Cannabinoid Receptor Agonists; Carbamates; Dose-Response Relationship, Drug; Endocannabinoids; Enzyme Inhibitors; Gene Expression Regulation; Interpersonal Relations; Male; Nucleus Accumbens; Phospholipase D; Phosphorylation; Piperidines; Play and Playthings; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Reward; Rimonabant

2012
Alterations in endocannabinoid tone following chemotherapy-induced peripheral neuropathy: effects of endocannabinoid deactivation inhibitors targeting fatty-acid amide hydrolase and monoacylglycerol lipase in comparison to reference analgesics following c
    Pharmacological research, 2013, Volume: 67, Issue:1

    Topics: Amidohydrolases; Analgesics; Animals; Antineoplastic Agents; Arachidonic Acids; Benzamides; Benzodioxoles; Cannabinoids; Carbamates; Cisplatin; Endocannabinoids; Enzyme Inhibitors; Ganglia, Spinal; Glycerides; Hyperalgesia; Lipid Metabolism; Male; Monoacylglycerol Lipases; Peripheral Nervous System Diseases; Piperidines; Polyunsaturated Alkamides; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; RNA, Messenger; Spinal Cord; TRPV Cation Channels

2013
Fatty acid amide hydrolase deficiency enhances intraplaque neutrophil recruitment in atherosclerotic mice.
    Arteriosclerosis, thrombosis, and vascular biology, 2013, Volume: 33, Issue:2

    Topics: Amides; Amidohydrolases; Animals; Aorta; Aortic Diseases; Apolipoproteins E; Arachidonic Acids; Atherosclerosis; Benzamides; Carbamates; Cells, Cultured; Chemokine CXCL1; Cholesterol; Disease Models, Animal; Endocannabinoids; Enzyme Inhibitors; Ethanolamines; Genotype; Inflammation Mediators; Interferon-gamma; Matrix Metalloproteinase 9; Mice; Mice, Inbred C57BL; Mice, Knockout; Muscle, Smooth, Vascular; Neutrophil Infiltration; Neutrophils; Oleic Acids; Palmitic Acids; Phenotype; Plaque, Atherosclerotic; Polyunsaturated Alkamides; Spleen; T-Lymphocytes, Regulatory; Time Factors; Tumor Necrosis Factor-alpha

2013
Inhibition of fatty acid amide hydrolase activates Nrf2 signalling and induces heme oxygenase 1 transcription in breast cancer cells.
    British journal of pharmacology, 2013, Volume: 170, Issue:3

    Topics: Active Transport, Cell Nucleus; Amidohydrolases; Antineoplastic Agents; Arachidonic Acids; Benzamides; Breast Neoplasms; Carbamates; Cell Survival; Dose-Response Relationship, Drug; Endocannabinoids; Enzyme Induction; Enzyme Inhibitors; Female; Gene Expression Regulation, Neoplastic; Heme Oxygenase-1; Humans; MCF-7 Cells; NF-E2-Related Factor 2; Polyunsaturated Alkamides; RNA Interference; Signal Transduction; Transcription, Genetic; Transfection

2013
Effects of cannabinoids and endocannabinoid hydrolysis inhibition on pentylenetetrazole-induced seizure and electroencephalographic activity in rats.
    Epilepsy research, 2013, Volume: 104, Issue:3

    Topics: Animals; Benzamides; Benzoxazines; Cannabinoids; Carbamates; Convulsants; Disease Models, Animal; Electroencephalography; Endocannabinoids; Hydrolysis; Male; Morpholines; Naphthalenes; Pentylenetetrazole; Rats; Rats, Wistar; Seizures

2013
Inhibition of endocannabinoid degradation in experimental endotoxemia reduces leukocyte adhesion and improves capillary perfusion in the gut.
    Journal of basic and clinical physiology and pharmacology, 2013, Volume: 24, Issue:1

    Topics: Amidohydrolases; Animals; Benzamides; Cannabinoid Receptor Antagonists; Capillaries; Carbamates; Cell Adhesion; Disease Models, Animal; Endocannabinoids; Endotoxemia; Indoles; Intestinal Mucosa; Intestines; Leukocytes; Lipopolysaccharides; Male; Rats; Rats, Inbred Lew; Receptor, Cannabinoid, CB2

2013
Quantum mechanics/molecular mechanics modeling of fatty acid amide hydrolase reactivation distinguishes substrate from irreversible covalent inhibitors.
    Journal of medicinal chemistry, 2013, Mar-28, Volume: 56, Issue:6

    Topics: Acylation; Amidohydrolases; Benzamides; Carbamates; Enzyme Activation; Enzyme Inhibitors; Enzyme Stability; Models, Molecular; Protein Conformation; Quantum Theory

2013
PPARα regulates cholinergic-driven activity of midbrain dopamine neurons via a novel mechanism involving α7 nicotinic acetylcholine receptors.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2013, Apr-03, Volume: 33, Issue:14

    Topics: Action Potentials; alpha7 Nicotinic Acetylcholine Receptor; Analysis of Variance; Animals; Animals, Newborn; Benzamides; Bridged Bicyclo Compounds; Carbamates; Cholinergic Agents; Dihydro-beta-Erythroidine; Dopaminergic Neurons; Drug Interactions; Enzyme Inhibitors; Ethanolamines; Excitatory Amino Acid Antagonists; In Vitro Techniques; Ligands; Male; Patch-Clamp Techniques; PPAR alpha; Pyrimidines; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic; Swimming; Tyrosine 3-Monooxygenase; Ventral Tegmental Area

2013
Phencyclidine-induced social withdrawal results from deficient stimulation of cannabinoid CB₁ receptors: implications for schizophrenia.
    Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2013, Volume: 38, Issue:9

    Topics: Amidohydrolases; Amygdala; Animals; Arachidonic Acids; Benzamides; Cannabinoid Receptor Agonists; Cannabinoid Receptor Antagonists; Carbamates; Cyclohexanols; Dose-Response Relationship, Drug; Endocannabinoids; Male; Phencyclidine; Piperidines; Polyunsaturated Alkamides; Prefrontal Cortex; Pyrazoles; Quinazolinones; Rats; Receptor, Cannabinoid, CB1; Receptor, Cholecystokinin B; Rimonabant; Schizophrenia; Social Behavior

2013
Full inhibition of spinal FAAH leads to TRPV1-mediated analgesic effects in neuropathic rats and possible lipoxygenase-mediated remodeling of anandamide metabolism.
    PloS one, 2013, Volume: 8, Issue:4

    Topics: Amides; Amidohydrolases; Analgesia; Animals; Arachidonate 15-Lipoxygenase; Arachidonic Acids; Benzamides; Calcium Signaling; Carbamates; Diterpenes; Endocannabinoids; Ethanolamines; Flavanones; Glycerides; HEK293 Cells; Humans; Hyperalgesia; Injections, Spinal; Lipoxygenase Inhibitors; Male; Neuralgia; Oleic Acids; Palmitic Acids; Polyunsaturated Alkamides; Posterior Horn Cells; Rats; Rats, Wistar; Sciatic Nerve; Spinal Cord; TRPV Cation Channels

2013
The fatty acid amide hydrolase inhibitor, URB597, promotes retinal ganglion cell neuroprotection in a rat model of optic nerve axotomy.
    Neuropharmacology, 2013, Volume: 72

    Topics: Age Factors; Amidohydrolases; Animals; Axotomy; Benzamides; Carbamates; Cell Count; Disease Models, Animal; Endocannabinoids; Indoles; Microglia; Morpholines; Neural Pathways; Neuroprotective Agents; Optic Nerve Diseases; Pyrazoles; Rats; Rats, Inbred F344; Retina; Retinal Ganglion Cells; Stilbamidines

2013
Increased anandamide uptake by sensory neurons contributes to hyperalgesia in a model of cancer pain.
    Neurobiology of disease, 2013, Volume: 58

    Topics: Animals; Arachidonic Acids; Benzamides; Brain Neoplasms; Cannabinoid Receptor Antagonists; Carbamates; Cells, Cultured; Coculture Techniques; Disease Models, Animal; Endocannabinoids; Enzyme Inhibitors; Fibrosarcoma; Fluorescent Dyes; Ganglia, Spinal; Hyperalgesia; Indoles; Lactones; Male; Mice; Mice, Inbred C3H; Pain; Pain Threshold; Polyunsaturated Alkamides; Sensory Receptor Cells; Statistics, Nonparametric; Tritium

2013
Effects of compounds that interfere with the endocannabinoid system on behaviors predictive of anxiolytic and panicolytic activities in the elevated T-maze.
    Pharmacology, biochemistry, and behavior, 2013, Volume: 110

    Topics: Alprazolam; Animals; Anti-Anxiety Agents; Behavior, Animal; Benzamides; Benzodiazepines; Benzoxazines; Carbamates; Endocannabinoids; Locomotion; Male; Maze Learning; Morpholines; Naphthalenes; Panic; Piperidines; Pyrazoles; Rats; Receptor, Cannabinoid, CB1

2013
The effects of anandamide signaling enhanced by the FAAH inhibitor URB597 on coping styles in rats.
    Psychopharmacology, 2013, Volume: 230, Issue:3

    Topics: Adaptation, Psychological; Amidohydrolases; Animals; Arachidonic Acids; Behavior, Animal; Benzamides; Carbamates; Endocannabinoids; Male; Maze Learning; Polyunsaturated Alkamides; Rats; Rats, Wistar; Signal Transduction

2013
Anandamide modulates the neuroendocrine responses induced by extracellular volume expansion.
    Clinical and experimental pharmacology & physiology, 2013, Volume: 40, Issue:10

    Topics: Amidohydrolases; Animals; Arachidonic Acids; Benzamides; Carbamates; Endocannabinoids; Gene Expression Regulation; Infusions, Intraventricular; Male; Median Eminence; Neuroprotective Agents; Nitrates; Oxytocin; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; RNA, Messenger; Saline Solution, Hypertonic; Vasopressins

2013
Effects of endocannabinoid and endovanilloid systems on aversive memory extinction.
    Behavioural brain research, 2013, Nov-01, Volume: 256

    Topics: Amidohydrolases; Animals; Arachidonic Acids; Benzamides; Carbamates; Endocannabinoids; Enzyme Inhibitors; Extinction, Psychological; Fear; Freezing Reaction, Cataleptic; Male; Memory; Mice, Inbred C57BL; Polyunsaturated Alkamides; Receptor, Cannabinoid, CB1; Social Dominance; Stress, Psychological; Time Factors; TRPV Cation Channels

2013
Effects of the fatty acid amide hydrolase inhibitor URB597 on coping behavior under challenging conditions in mice.
    Psychopharmacology, 2014, Volume: 231, Issue:3

    Topics: Adaptation, Psychological; Amidohydrolases; Animals; Arachidonic Acids; Benzamides; Carbamates; Electrodes, Implanted; Electroencephalography; Electromyography; Electroshock; Endocannabinoids; Enzyme Inhibitors; Escape Reaction; Freezing Reaction, Cataleptic; Male; Mice, Inbred Strains; Motor Activity; Polyunsaturated Alkamides; Restraint, Physical; Sleep; Stress, Psychological

2014
Endocannabinoid anandamide mediates hypoxic pulmonary vasoconstriction.
    Proceedings of the National Academy of Sciences of the United States of America, 2013, Nov-12, Volume: 110, Issue:46

    Topics: Amidohydrolases; Analysis of Variance; Animals; Arachidonic Acids; Benzamides; Blotting, Western; Carbamates; Chromatography, Liquid; DNA Primers; Endocannabinoids; Hypertension, Pulmonary; Hypoxia; Immunohistochemistry; Lung; Mice; Mice, Knockout; Myocytes, Smooth Muscle; Polyunsaturated Alkamides; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction; Vasoconstriction

2013
Monounsaturated fatty acids generated via stearoyl CoA desaturase-1 are endogenous inhibitors of fatty acid amide hydrolase.
    Proceedings of the National Academy of Sciences of the United States of America, 2013, Nov-19, Volume: 110, Issue:47

    Topics: Amidohydrolases; Analysis of Variance; Animals; Arachidonic Acids; Benzamides; Carbamates; Endocannabinoids; Fatty Acids, Monounsaturated; Feedback, Physiological; Insulin Resistance; Liver; Male; Mice; Mice, Inbred C57BL; Obesity; Polyunsaturated Alkamides; Receptor, Cannabinoid, CB1; Stearoyl-CoA Desaturase

2013
Endocannabinoids underlie reconsolidation of hedonic memories in Wistar rats.
    Psychopharmacology, 2014, Volume: 231, Issue:7

    Topics: Amidohydrolases; Animals; Benzamides; Benzoxazines; Carbamates; Conditioning, Psychological; Cues; Endocannabinoids; Indoles; Male; Memory; Morphine; Morpholines; Naphthalenes; Piperidines; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Recurrence; Rimonabant; Secondary Prevention

2014
Inhibition of endocannabinoid-degrading enzyme fatty acid amide hydrolase increases atherosclerotic plaque vulnerability in mice.
    Journal of molecular and cellular cardiology, 2014, Volume: 66

    Topics: Amidohydrolases; Animals; Apolipoproteins E; Arachidonic Acids; Benzamides; Carbamates; Cell Movement; Diet, High-Fat; Dietary Fats; Endocannabinoids; Enzyme Inhibitors; Gene Expression; Macrophages; Mice; Mice, Knockout; Neutrophils; Plaque, Atherosclerotic; Polyunsaturated Alkamides; Superoxides

2014
Prenatal corticosterone and adolescent URB597 administration modulate emotionality and CB1 receptor expression in mice.
    Psychopharmacology, 2014, Volume: 231, Issue:10

    Topics: Animals; Benzamides; Brain; Carbamates; Corticosterone; Emotions; Female; Hypothalamo-Hypophyseal System; Male; Mice; Motor Activity; Pituitary-Adrenal System; Pregnancy; Prenatal Exposure Delayed Effects; Receptor, Cannabinoid, CB1

2014
Actions of the dual FAAH/MAGL inhibitor JZL195 in a murine inflammatory pain model.
    Neuropharmacology, 2014, Volume: 81

    Topics: Amidohydrolases; Analgesics; Analysis of Variance; Animals; Arthritis, Experimental; Benzamides; Benzoxazines; Carbamates; Disease Models, Animal; Dose-Response Relationship, Drug; Exploratory Behavior; Male; Mice; Mice, Inbred C57BL; Morpholines; Motor Activity; Naphthalenes; Pain; Pain Measurement; Piperazines; Piperidines; Pyrazoles; Time Factors

2014
Effects of the fatty acid amide hydrolase inhibitor URB597 on pain-stimulated and pain-depressed behavior in rats.
    Behavioural pharmacology, 2014, Volume: 25, Issue:2

    Topics: Amidohydrolases; Analgesics; Animals; Arachidonic Acids; Behavior, Animal; Benzamides; Brain; Carbamates; Conditioning, Operant; Depression; Dose-Response Relationship, Drug; Electric Stimulation; Endocannabinoids; Enzyme Inhibitors; Implantable Neurostimulators; Injections, Intraperitoneal; Lactic Acid; Male; Pain; Polyunsaturated Alkamides; Rats; Rats, Sprague-Dawley; Receptors, Cannabinoid; Self Administration

2014
Elevation of endogenous anandamide impairs LTP, learning, and memory through CB1 receptor signaling in mice.
    Hippocampus, 2014, Volume: 24, Issue:7

    Topics: Amidohydrolases; Animals; Arachidonic Acids; Benzamides; Calcium-Calmodulin-Dependent Protein Kinase Type 4; Carbamates; Cyclic AMP Response Element-Binding Protein; Endocannabinoids; Glycerides; Learning; Long-Term Potentiation; Male; MAP Kinase Signaling System; Maze Learning; Memory; Mice; Mice, Inbred C57BL; Mice, Knockout; Phosphorylation; Polyunsaturated Alkamides; Protein Processing, Post-Translational; Receptor, Cannabinoid, CB1; Spatial Memory

2014
Antidepressants and changes in concentration of endocannabinoids and N-acylethanolamines in rat brain structures.
    Neurotoxicity research, 2014, Volume: 26, Issue:2

    Topics: Acetylcysteine; Amides; Amidohydrolases; Animals; Antidepressive Agents; Arachidonic Acids; Benzamides; Brain; Carbamates; Citalopram; Endocannabinoids; Enzyme Inhibitors; Ethanolamines; Expectorants; Glycerides; Imipramine; Male; Oleic Acids; Palmitic Acids; Polyunsaturated Alkamides; Rats, Wistar; Thiazepines

2014
Effects of endogenous cannabinoid anandamide on cardiac Na⁺/Ca²⁺ exchanger.
    Cell calcium, 2014, Volume: 55, Issue:5

    Topics: Animals; Arachidonic Acids; Benzamides; Calcium Channel Blockers; Carbamates; Cells, Cultured; Endocannabinoids; HEK293 Cells; Humans; Male; Microscopy, Confocal; Myocytes, Cardiac; Patch-Clamp Techniques; Polyunsaturated Alkamides; Rats; Rats, Wistar; Sodium-Calcium Exchanger

2014
Prior stimulation of the endocannabinoid system prevents methamphetamine-induced dopaminergic neurotoxicity in the striatum through activation of CB2 receptors.
    Neuropharmacology, 2014, Volume: 87

    Topics: Animals; Arachidonic Acids; Benzamides; Benzodioxoles; Cannabinoid Receptor Modulators; Carbamates; Central Nervous System Stimulants; Dronabinol; Endocannabinoids; Enzyme Inhibitors; Glycerides; Male; Methamphetamine; Mice, Inbred C57BL; Neostriatum; Neurotoxicity Syndromes; Piperidines; Polyunsaturated Alkamides; Random Allocation; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Tumor Necrosis Factor-alpha; Tyrosine 3-Monooxygenase

2014
Long-term consequences of perinatal fatty acid amino hydrolase inhibition.
    British journal of pharmacology, 2014, Volume: 171, Issue:6

    Topics: Amidohydrolases; Animals; Behavior, Animal; Benzamides; Carbamates; Dose-Response Relationship, Drug; Enzyme Inhibitors; Female; Mice; Mice, Inbred ICR; Pregnancy

2014
Fatty acid amide hydrolase (FAAH) inhibitors exert pharmacological effects, but lack antinociceptive efficacy in rats with neuropathic spinal cord injury pain.
    PloS one, 2014, Volume: 9, Issue:5

    Topics: Amidohydrolases; Analgesics; Animals; Arachidonic Acids; Benzamides; Benzoxazines; Brain; Carbamates; Endocannabinoids; Enzyme Inhibitors; Hindlimb; Male; Morpholines; Naphthalenes; Neuralgia; Pain Measurement; Pain Threshold; Piperidines; Polyunsaturated Alkamides; Pyridines; Rats, Sprague-Dawley; Spinal Cord; Spinal Cord Injuries; Treatment Outcome

2014
The CB1 receptor antagonist AM251 impairs reconsolidation of pavlovian fear memory in the rat basolateral amygdala.
    Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2014, Volume: 39, Issue:11

    Topics: Amidohydrolases; Animals; Auditory Perception; Basolateral Nuclear Complex; Benzamides; Bicuculline; Cannabinoid Receptor Antagonists; Carbamates; Conditioning, Classical; Electroshock; Enzyme Inhibitors; Fear; GABA-A Receptor Antagonists; Male; Memory; Piperidines; Pyrazoles; Rats; Receptor, Cannabinoid, CB1; Receptors, GABA-A

2014
Attenuation of serotonin-induced itch responses by inhibition of endocannabinoid degradative enzymes, fatty acid amide hydrolase and monoacylglycerol lipase.
    Journal of neural transmission (Vienna, Austria : 1996), 2015, Volume: 122, Issue:3

    Topics: Amidohydrolases; Animals; Arachidonic Acids; Benzamides; Benzodioxoles; Camphanes; Carbamates; Endocannabinoids; Enzyme Inhibitors; Male; Mice; Mice, Inbred BALB C; Monoacylglycerol Lipases; Piperidines; Pruritus; Pyrazoles; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Serotonin

2015
Strain- and context-dependent effects of the anandamide hydrolysis inhibitor URB597 on social behavior in rats.
    European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology, 2014, Volume: 24, Issue:8

    Topics: Age Factors; Amidohydrolases; Analysis of Variance; Animals; Behavior, Animal; Benzamides; Carbamates; Conditioning, Psychological; Dose-Response Relationship, Drug; Male; Rats; Rats, Sprague-Dawley; Rats, Wistar; Social Behavior; Species Specificity; Vocalization, Animal

2014
Increased angiotensin II contraction of the uterine artery at early gestation in a transgenic model of hypertensive pregnancy is reduced by inhibition of endocannabinoid hydrolysis.
    Hypertension (Dallas, Tex. : 1979), 2014, Volume: 64, Issue:3

    Topics: Amidohydrolases; Angiotensin II; Animals; Arachidonic Acids; Benzamides; Benzodioxoles; Blood Pressure; Carbamates; Disease Models, Animal; Endocannabinoids; Female; Glycerides; Humans; Hydrolysis; Hypertension, Pregnancy-Induced; Male; Monoglycerides; Piperidines; Polyunsaturated Alkamides; Pregnancy; Pregnancy, Animal; Rats; Rats, Sprague-Dawley; Rats, Transgenic; Uterine Artery; Vasoconstriction

2014
PET imaging of fatty acid amide hydrolase with [(18)F]DOPP in nonhuman primates.
    Molecular pharmaceutics, 2014, Nov-03, Volume: 11, Issue:11

    Topics: Amidohydrolases; Animals; Benzamides; Blood-Brain Barrier; Brain; Carbamates; Endocannabinoids; Fluorine Radioisotopes; Magnetic Resonance Imaging; Models, Chemical; Oxazoles; Papio; Positron-Emission Tomography; Primates; Tissue Distribution

2014
Endocannabinoid modulation by FAAH and monoacylglycerol lipase within the analgesic circuitry of the periaqueductal grey.
    British journal of pharmacology, 2014, Volume: 171, Issue:23

    Topics: Amidohydrolases; Animals; Arachidonic Acids; Benzamides; Benzodioxoles; Carbamates; Endocannabinoids; Female; Glycerides; In Vitro Techniques; Inhibitory Postsynaptic Potentials; Male; Monoacylglycerol Lipases; Neurons; Pain; Periaqueductal Gray; Piperidines; Polyunsaturated Alkamides; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Synaptic Transmission

2014
Therapeutic potential of inhibitors of endocannabinoid degradation for the treatment of stress-related hyperalgesia in an animal model of chronic pain.
    Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2015, Volume: 40, Issue:2

    Topics: Amidohydrolases; Analgesics, Non-Narcotic; Animals; Anxiety; Benzamides; Benzodioxoles; Brain; Carbamates; Chronic Pain; Depression; Disease Models, Animal; Endocannabinoids; Enzyme Inhibitors; Hyperalgesia; Male; Mice, Inbred C57BL; Monoacylglycerol Lipases; Nerve Growth Factor; Piperidines; Stress, Psychological; Uncertainty

2015
Role of the basolateral amygdala in mediating the effects of the fatty acid amide hydrolase inhibitor URB597 on HPA axis response to stress.
    European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology, 2014, Volume: 24, Issue:9

    Topics: Analysis of Variance; Animals; Basolateral Nuclear Complex; Benzamides; Carbamates; Corticotropin-Releasing Hormone; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme Inhibitors; Gene Expression Regulation; Hypothalamo-Hypophyseal System; Male; Paraventricular Hypothalamic Nucleus; Piperidines; Pituitary-Adrenal System; Pro-Opiomelanocortin; Pyrazoles; Rats; RNA, Messenger; Stress, Psychological; Swimming; Time Factors

2014
Blockade of monoacylglycerol lipase inhibits oligodendrocyte excitotoxicity and prevents demyelination in vivo.
    Glia, 2015, Volume: 63, Issue:1

    Topics: Amidohydrolases; Animals; Benzamides; Benzodioxoles; Cannabinoid Receptor Modulators; Carbamates; Demyelinating Diseases; Monoacylglycerol Lipases; Multiple Sclerosis; Oligodendroglia; Piperidines; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1

2015
Endocannabinoid degradation inhibition improves neurobehavioral function, blood-brain barrier integrity, and neuroinflammation following mild traumatic brain injury.
    Journal of neurotrauma, 2015, Mar-01, Volume: 32, Issue:5

    Topics: Animals; Arachidonic Acids; Benzamides; Benzodioxoles; Blood-Brain Barrier; Blotting, Western; Brain Injuries; Carbamates; Disease Models, Animal; Endocannabinoids; Glycerides; Immunohistochemistry; Inflammation; Male; Neuroprotective Agents; Piperidines; Polyunsaturated Alkamides; Rats; Rats, Sprague-Dawley; Real-Time Polymerase Chain Reaction; Recovery of Function

2015
Interaction between the cholecystokinin and endogenous cannabinoid systems in cued fear expression and extinction retention.
    Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2015, Volume: 40, Issue:3

    Topics: Amidohydrolases; Animals; Benzamides; Cannabinoid Receptor Antagonists; Carbamates; Cholecystokinin; Conditioning, Psychological; Cues; Dose-Response Relationship, Drug; Extinction, Psychological; Fear; Male; Mice; Mice, Knockout; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Receptor, Cholecystokinin B; Rimonabant

2015
FAAH-mediated modulation of TLR3-induced neuroinflammation in the rat hippocampus.
    Journal of neuroimmunology, 2014, Nov-15, Volume: 276, Issue:1-2

    Topics: Amidohydrolases; Animals; Benzamides; Carbamates; Chromatography, Liquid; Cytokines; Drug Administration Routes; Encephalitis; Enzyme Inhibitors; Gene Expression Regulation; Hippocampus; Interferon Inducers; Male; Poly I-C; Rats; Rats, Sprague-Dawley; RNA, Messenger; Tandem Mass Spectrometry; Toll-Like Receptor 3

2014
Tapping into the endocannabinoid system to ameliorate acute inflammatory flares and associated pain in mouse knee joints.
    Arthritis research & therapy, 2014, Sep-27, Volume: 16, Issue:5

    Topics: Acute Disease; Amidohydrolases; Animals; Arthralgia; Benzamides; Carbamates; Carrageenan; Endocannabinoids; Hindlimb; Hyperalgesia; Indoles; Inflammation; Kaolin; Knee Joint; Male; Mice, Inbred C57BL; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Synovitis; Weight-Bearing

2014
Anti-aversive role of the endocannabinoid system in the periaqueductal gray stimulation model of panic attacks in rats.
    Psychopharmacology, 2015, Volume: 232, Issue:9

    Topics: Amidohydrolases; Animals; Anxiety; Arachidonic Acids; Behavior, Animal; Benzamides; Carbamates; Disease Models, Animal; Endocannabinoids; Enzyme Inhibitors; Male; N-Methylaspartate; Panic Disorder; Periaqueductal Gray; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1

2015
Development of [(11)C]MFTC for PET imaging of fatty acid amide hydrolase in rat and monkey brains.
    ACS chemical neuroscience, 2015, Feb-18, Volume: 6, Issue:2

    Topics: Amidohydrolases; Animals; Benzamides; Brain; Carbamates; Carbon Radioisotopes; Enzyme Inhibitors; Kidney; Liver; Lung; Macaca mulatta; Mice; Positron-Emission Tomography; Radiopharmaceuticals; Rats; Species Specificity

2015
Normal aging in rats and pathological aging in human Alzheimer's disease decrease FAAH activity: modulation by cannabinoid agonists.
    Experimental gerontology, 2014, Volume: 60

    Topics: Aged; Aged, 80 and over; Aging; Alzheimer Disease; Amidohydrolases; Amyloid beta-Peptides; Animals; Arachidonic Acids; Benzamides; Benzoxazines; Cannabinoid Receptor Agonists; Cannabinoids; Carbamates; Case-Control Studies; Cerebral Cortex; Endocannabinoids; Enzyme Inhibitors; Female; Frontal Lobe; Humans; In Vitro Techniques; Male; Middle Aged; Morpholines; Naphthalenes; Polyunsaturated Alkamides; Rats; Rats, Wistar; Synaptosomes

2014
Attenuation of persistent pain-related behavior by fatty acid amide hydrolase (FAAH) inhibitors in a rat model of HIV sensory neuropathy.
    Neuropharmacology, 2015, Volume: 95

    Topics: Amidohydrolases; Amines; Analgesics; Animals; Benzamides; Carbamates; Cyclohexanecarboxylic Acids; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme Inhibitors; Gabapentin; gamma-Aminobutyric Acid; HIV Envelope Protein gp120; HIV Infections; Hyperalgesia; Male; Nociception; Piperidines; Pyridines; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Recombinant Proteins; Sciatic Neuropathy

2015
Endogenous cannabinoid release within prefrontal-limbic pathways affects memory consolidation of emotional training.
    Proceedings of the National Academy of Sciences of the United States of America, 2014, Dec-23, Volume: 111, Issue:51

    Topics: Amidohydrolases; Animals; Arachidonic Acids; Avoidance Learning; Benzamides; Carbamates; Emotions; Endocannabinoids; Glycerides; Limbic System; Memory; Polyunsaturated Alkamides; Prefrontal Cortex; Rats; Receptor, Cannabinoid, CB1

2014
Inhibition of anandamide hydrolysis attenuates nociceptor sensitization in a murine model of chemotherapy-induced peripheral neuropathy.
    Journal of neurophysiology, 2015, Mar-01, Volume: 113, Issue:5

    Topics: Amidohydrolases; Animals; Arachidonic Acids; Benzamides; Cannabinoid Receptor Antagonists; Carbamates; Cisplatin; Endocannabinoids; Hydrolysis; Indoles; Male; Mice; Morpholines; Nerve Fibers, Unmyelinated; Nociception; Nociceptors; Peripheral Nervous System Diseases; Polyunsaturated Alkamides; Pyrazoles; Skin

2015
Interaction between the endocannabinoid and serotonergic system in the exhibition of head twitch response in four mouse strains.
    Neurotoxicity research, 2015, Volume: 27, Issue:3

    Topics: Amphetamines; Animals; Benzamides; Cannabinoid Receptor Agonists; Carbamates; Head Movements; Male; Mice; Mice, Inbred C57BL; Serotonin Receptor Agonists; Species Specificity

2015
Chronic stimulation of the tone of endogenous anandamide reduces cue- and stress-induced relapse in rats.
    The international journal of neuropsychopharmacology, 2014, Dec-05, Volume: 18, Issue:1

    Topics: Amidohydrolases; Animals; Arachidonic Acids; Benzamides; Carbamates; Cocaine; Cocaine-Related Disorders; Cues; Disease Models, Animal; Dopamine Uptake Inhibitors; Drug-Seeking Behavior; Endocannabinoids; Enzyme Inhibitors; Male; Polyunsaturated Alkamides; Rats, Sprague-Dawley; Recurrence; Self Administration; Stress, Physiological; Yohimbine

2014
Increasing endocannabinoid levels in the ventral pallidum restore aberrant dopamine neuron activity in the subchronic PCP rodent model of schizophrenia.
    The international journal of neuropsychopharmacology, 2014, Oct-31, Volume: 18, Issue:1

    Topics: Animals; Basal Forebrain; Benzamides; Carbamates; Central Nervous System Agents; Disease Models, Animal; Dopaminergic Neurons; Endocannabinoids; Hippocampus; Male; Microelectrodes; Phencyclidine; Rats, Sprague-Dawley; Schizophrenia; Sodium Channel Blockers; Tetrodotoxin; Ventral Tegmental Area

2014
Inhibition of anandamide hydrolysis enhances noradrenergic and GABAergic transmission in the prefrontal cortex and basolateral amygdala of rats subjected to acute swim stress.
    Journal of neuroscience research, 2015, Volume: 93, Issue:5

    Topics: Analysis of Variance; Animals; Arachidonic Acids; Basolateral Nuclear Complex; Benzamides; Carbamates; Chromatography, High Pressure Liquid; Disease Models, Animal; Endocannabinoids; Extracellular Fluid; gamma-Aminobutyric Acid; Male; Microdialysis; Norepinephrine; Polyunsaturated Alkamides; Prefrontal Cortex; Rats; Rats, Wistar; Stress, Psychological; Swimming

2015
Cannabinoid CB1 receptors in the dorsal hippocampus and prelimbic medial prefrontal cortex modulate anxiety-like behavior in rats: additional evidence.
    Progress in neuro-psychopharmacology & biological psychiatry, 2015, Jun-03, Volume: 59

    Topics: Animals; Anxiety; Arachidonic Acids; Benzamides; Carbamates; Disease Models, Animal; Drinking; Drinking Behavior; Electric Stimulation; Enzyme Inhibitors; Hippocampus; Male; Maze Learning; Prefrontal Cortex; Rats; Rats, Wistar; Reaction Time; Receptor, Cannabinoid, CB1; Statistics, Nonparametric; Tail; Time Factors; Vocalization, Animal

2015
Role of endocannabinoid signalling in the dorsolateral periaqueductal grey in the modulation of distinct panic-like responses.
    Journal of psychopharmacology (Oxford, England), 2015, Volume: 29, Issue:3

    Topics: Animals; Arachidonic Acids; Benzamides; Carbamates; Disease Models, Animal; Dose-Response Relationship, Drug; Endocannabinoids; Escape Reaction; Male; Maze Learning; Panic Disorder; Periaqueductal Gray; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Signal Transduction

2015
Increased Contextual Fear Conditioning in iNOS Knockout Mice: Additional Evidence for the Involvement of Nitric Oxide in Stress-Related Disorders and Contribution of the Endocannabinoid System.
    The international journal of neuropsychopharmacology, 2015, Jan-24, Volume: 18, Issue:8

    Topics: Animals; Arachidonic Acids; Benzamides; Benzoxazines; Cannabinoid Receptor Agonists; Cannabinoid Receptor Antagonists; Carbamates; Conditioning, Psychological; Endocannabinoids; Enzyme Inhibitors; Extinction, Psychological; Fear; Freezing Reaction, Cataleptic; Hippocampus; Indazoles; Male; Mice, Inbred C57BL; Mice, Knockout; Morpholines; Naphthalenes; Nitric Oxide; Nitric Oxide Synthase Type II; Polyunsaturated Alkamides; Prefrontal Cortex; Pyrazoles; Receptor, Cannabinoid, CB1; RNA, Messenger; Stress, Psychological

2015
Effects of URB597 as an inhibitor of fatty acid amide hydrolase on WIN55, 212-2-induced learning and memory deficits in rats.
    Pharmacology, biochemistry, and behavior, 2015, Volume: 131

    Topics: Amidohydrolases; Animals; Benzamides; Benzoxazines; Carbamates; Learning; Male; Memory Disorders; Morpholines; Naphthalenes; Nootropic Agents; Piperidines; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Retention, Psychology; Rimonabant

2015
A multi-target approach for pain treatment: dual inhibition of fatty acid amide hydrolase and TRPV1 in a rat model of osteoarthritis.
    Pain, 2015, Volume: 156, Issue:5

    Topics: Activating Transcription Factor 3; Amidohydrolases; Anilides; Animals; Arachidonic Acids; Benzamides; Capsaicin; Carbamates; Cinnamates; Disease Models, Animal; Endocannabinoids; Ganglia, Spinal; Gene Expression; Hyperalgesia; Inflammation; Interleukin-6; Lumbar Vertebrae; Male; Osteoarthritis; Pain; Pain Management; Pain Measurement; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; TRPV Cation Channels

2015
Effects of Fatty Acid Amide Hydrolase (FAAH) Inhibitors in Non-Human Primate Models of Nicotine Reward and Relapse.
    Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2015, Volume: 40, Issue:9

    Topics: Animals; Benzamides; Biphenyl Compounds; Brain; Carbamates; Cues; Dopamine; Dose-Response Relationship, Drug; Drug-Seeking Behavior; Extinction, Psychological; Male; Mixed Function Oxygenases; Models, Animal; Nicotine; Nicotinic Agonists; Rats; Rats, Sprague-Dawley; Recurrence; Reward; Saimiri; Self Administration; Time Factors

2015
Attenuation of kainic acid-induced status epilepticus by inhibition of endocannabinoid transport and degradation in guinea pigs.
    Epilepsy research, 2015, Volume: 111

    Topics: Amidohydrolases; Animals; Anticonvulsants; Arachidonic Acids; Benzamides; Biological Transport; Brain; Cannabinoid Receptor Antagonists; Carbamates; Endocannabinoids; Guinea Pigs; Kainic Acid; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Seizures; Status Epilepticus

2015
Cannabinoid receptor agonist WIN55,212-2 and fatty acid amide hydrolase inhibitor URB597 suppress chronic cerebral hypoperfusion-induced neuronal apoptosis by inhibiting c-Jun N-terminal kinase signaling.
    Neuroscience, 2015, Aug-20, Volume: 301

    Topics: Animals; Apoptosis; Benzamides; Benzoxazines; Calcium Channel Blockers; Carbamates; Carotid Stenosis; Cerebral Cortex; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Inhibitors; JNK Mitogen-Activated Protein Kinases; Male; Maze Learning; Morpholines; Naphthalenes; Neurons; Phosphopyruvate Hydratase; Rats; Rats, Sprague-Dawley; Signal Transduction; Time Factors

2015
Inhibition of FAAH reduces nitroglycerin-induced migraine-like pain and trigeminal neuronal hyperactivity in mice.
    European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology, 2015, Volume: 25, Issue:8

    Topics: Amidohydrolases; Analgesics; Animals; Arachidonic Acids; Benzamides; Cannabinoid Receptor Antagonists; Carbamates; Disease Models, Animal; Dose-Response Relationship, Drug; Endocannabinoids; Enzyme Inhibitors; Hyperalgesia; Male; Mice, Inbred C57BL; Mice, Knockout; Migraine Disorders; Monoacylglycerol Lipases; Nitroglycerin; Pain Measurement; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Rimonabant; Touch; Trigeminal Nuclei

2015
Enhanced function of inhibitory presynaptic cannabinoid CB1 receptors on sympathetic nerves of DOCA-salt hypertensive rats.
    Life sciences, 2015, Oct-01, Volume: 138

    Topics: Animals; Benzamides; Blood Pressure; Cannabinoid Receptor Agonists; Cannabinoid Receptor Antagonists; Carbamates; Desoxycorticosterone Acetate; Hypertension; Male; Nephrectomy; Phenylephrine; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Receptors, Presynaptic; Sodium, Dietary; Sympathetic Nervous System

2015
Enhancement of endocannabinoid signaling protects against cocaine-induced neurotoxicity.
    Toxicology and applied pharmacology, 2015, Aug-01, Volume: 286, Issue:3

    Topics: Animals; Benzamides; Carbamates; Cell Death; Cells, Cultured; Cocaine; Dose-Response Relationship, Drug; Endocannabinoids; Hippocampus; Male; Mice; Mice, Inbred C57BL; Neuroprotective Agents; Receptor, Cannabinoid, CB1; Signal Transduction

2015
Cannabidiol effects in the prepulse inhibition disruption induced by amphetamine.
    Psychopharmacology, 2015, Volume: 232, Issue:16

    Topics: Amphetamine; Animals; Benzamides; Cannabidiol; Carbamates; Inhibition, Psychological; Male; Mice; Nucleus Accumbens; Prepulse Inhibition; Reflex, Startle

2015
Endocannabinoid-mediated improvement on a test of aversive memory in a mouse model of fragile X syndrome.
    Behavioural brain research, 2015, Sep-15, Volume: 291

    Topics: Amidohydrolases; Animals; Anxiety; Arachidonic Acids; Avoidance Learning; Benzamides; Cannabinoid Receptor Antagonists; Carbamates; Disease Models, Animal; Endocannabinoids; Enzyme Inhibitors; Fragile X Mental Retardation Protein; Fragile X Syndrome; Male; Memory; Mice, Inbred C57BL; Mice, Knockout; Piperidines; Polyunsaturated Alkamides; Propofol; Pyrazoles; Receptor, Cannabinoid, CB1; Receptors, GABA-A; Social Behavior

2015
Inhibition of fatty-acid amide hydrolyse (FAAH) exerts cognitive improvements in male but not female rats.
    Endocrine regulations, 2015, Volume: 49, Issue:3

    Topics: Amidohydrolases; Animals; Behavior, Animal; Benzamides; Brain; Carbamates; Cognition; Endocannabinoids; Enzyme Inhibitors; Exploratory Behavior; Female; Male; Memory, Short-Term; Motor Activity; Nootropic Agents; Rats, Sprague-Dawley; Recognition, Psychology; Sex Factors

2015
Inhibition of FAAH confers increased stem cell migration via PPARα.
    Journal of lipid research, 2015, Volume: 56, Issue:10

    Topics: Adipose Tissue; Amides; Amidohydrolases; Arachidonic Acids; Benzamides; Carbamates; Cell Movement; Cells, Cultured; Endocannabinoids; Enzyme Inhibitors; Ethanolamines; Glycerides; Humans; Mesenchymal Stem Cells; Oleic Acids; Palmitic Acids; Polyunsaturated Alkamides; PPAR alpha; Receptor, Cannabinoid, CB1; Serotonin

2015
Fatty acid amide hydrolase inhibitor URB597 prevented tolerance and cognitive deficits induced by chronic morphine administration in rats.
    Behavioural pharmacology, 2016, Volume: 27, Issue:1

    Topics: Amidohydrolases; Analgesics, Opioid; Animals; Avoidance Learning; Benzamides; Carbamates; Cognition Disorders; Drug Tolerance; Enzyme Inhibitors; Male; Memory Disorders; Morphine; Morphine Dependence; Nociception; Psychotropic Drugs; Random Allocation; Rats, Wistar

2016
Interference with acute nausea and anticipatory nausea in rats by fatty acid amide hydrolase (FAAH) inhibition through a PPARα and CB1 receptor mechanism, respectively: a double dissociation.
    Psychopharmacology, 2015, Volume: 232, Issue:20

    Topics: Acute Disease; Amidohydrolases; Animals; Anticipation, Psychological; Benzamides; Carbamates; Male; Nausea; Piperidines; PPAR alpha; Pyridines; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1

2015
Anandamide mediates cognitive judgement bias in rats.
    Neuropharmacology, 2016, Volume: 101

    Topics: Acoustic Stimulation; Analysis of Variance; Animals; Arachidonic Acids; Benzamides; Bias; Calcium Channel Blockers; Carbamates; Cognition; Conditioning, Psychological; Cues; Discrimination, Psychological; Dose-Response Relationship, Drug; Drug Interactions; Endocannabinoids; Judgment; Male; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rats

2016
Actions of the dual FAAH/MAGL inhibitor JZL195 in a murine neuropathic pain model.
    British journal of pharmacology, 2016, Volume: 173, Issue:1

    Topics: Amidohydrolases; Animals; Benzamides; Benzodioxoles; Benzoxazines; Carbamates; Disease Models, Animal; Dose-Response Relationship, Drug; Hyperalgesia; Male; Mice; Monoacylglycerol Lipases; Morpholines; Naphthalenes; Neuralgia; Piperazines; Piperidines

2016
Characterisation of (R)-2-(2-Fluorobiphenyl-4-yl)-N-(3-Methylpyridin-2-yl)Propanamide as a Dual Fatty Acid Amide Hydrolase: Cyclooxygenase Inhibitor.
    PloS one, 2015, Volume: 10, Issue:9

    Topics: Amides; Amidohydrolases; Animals; Arachidonic Acid; Arachidonic Acids; Benzamides; Brain; Carbamates; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Endocannabinoids; Flurbiprofen; Humans; Hydrolysis; Interferon-gamma; Ionomycin; Isoenzymes; Lipid Metabolism; Lipopolysaccharides; Male; Mice; Polyunsaturated Alkamides; Prostaglandins; RAW 264.7 Cells; Stereoisomerism

2015
Training-Associated Emotional Arousal Shapes Endocannabinoid Modulation of Spatial Memory Retrieval in Rats.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2015, Oct-14, Volume: 35, Issue:41

    Topics: Animals; Arachidonic Acids; Arousal; Benzamides; Benzoxazines; Calcium Channel Blockers; Cannabinoid Receptor Agonists; Carbamates; Corticosterone; Dose-Response Relationship, Drug; Emotions; Endocannabinoids; Enzyme Inhibitors; Glycerides; Hippocampus; Male; Maze Learning; Mental Recall; Morpholines; Naphthalenes; Rats; Rats, Sprague-Dawley; Spatial Learning; Stress, Psychological; Temperature

2015
Endocannabinoid signaling mediates oxytocin-driven social reward.
    Proceedings of the National Academy of Sciences of the United States of America, 2015, Nov-10, Volume: 112, Issue:45

    Topics: Analysis of Variance; Animals; Arachidonic Acids; Autism Spectrum Disorder; Benzamides; Benzodiazepines; Camphanes; Carbamates; Clozapine; Cocaine; Endocannabinoids; Immunohistochemistry; Infusions, Intraventricular; Lipids; Male; Mice; Mice, Inbred C57BL; Nucleus Accumbens; Oxytocin; Piperazines; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Receptors, Cannabinoid; Reward; Signal Transduction; Social Behavior

2015
Synthesis and Preliminary PET Imaging Studies of a FAAH Radiotracer ([¹¹C]MPPO) Based on α-Ketoheterocyclic Scaffold.
    ACS chemical neuroscience, 2016, Jan-20, Volume: 7, Issue:1

    Topics: Amidohydrolases; Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Benzamides; Brain; Carbamates; Carbon Radioisotopes; Enzyme Inhibitors; Male; Mice; Mice, Transgenic; Positron-Emission Tomography; Radiopharmaceuticals; Rats; Rats, Sprague-Dawley; Tissue Distribution

2016
THC and endocannabinoids differentially regulate neuronal activity in the prefrontal cortex and hippocampus in the subchronic PCP model of schizophrenia.
    Journal of psychopharmacology (Oxford, England), 2016, Volume: 30, Issue:2

    Topics: Animals; Arachidonic Acids; Benzamides; Carbamates; Disease Models, Animal; Dronabinol; Endocannabinoids; Hippocampus; Male; Phencyclidine; Polyunsaturated Alkamides; Prefrontal Cortex; Rats; Rats, Sprague-Dawley; Schizophrenia; Up-Regulation

2016
Inhibition of anandamide hydrolysis dampens the neuroendocrine response to stress in neonatal rats subjected to suboptimal rearing conditions.
    Stress (Amsterdam, Netherlands), 2016, Volume: 19, Issue:1

    Topics: Adrenocorticotropic Hormone; Amidohydrolases; Animals; Animals, Newborn; Arachidonic Acids; Behavior, Animal; Benzamides; Carbamates; Corticosterone; Endocannabinoids; Hydrolysis; Hypothalamus; Male; Neurosecretory Systems; Paraventricular Hypothalamic Nucleus; Polyunsaturated Alkamides; Rats; Rats, Sprague-Dawley; Restraint, Physical; Stress, Physiological; Stress, Psychological

2016
Fluorine nuclear magnetic resonance-based assay in living mammalian cells.
    Analytical biochemistry, 2016, Feb-15, Volume: 495

    Topics: Amidohydrolases; Benzamides; Carbamates; Fluorine; HEK293 Cells; Humans; Inhibitory Concentration 50; Nuclear Magnetic Resonance, Biomolecular

2016
N-(3,4-Dimethylisoxazol-5-yl)piperazine-4-[4-(2-fluoro-4-[(11)C]methylphenyl)thiazol-2-yl]-1-carboxamide: A promising positron emission tomography ligand for fatty acid amide hydrolase.
    Bioorganic & medicinal chemistry, 2016, Feb-15, Volume: 24, Issue:4

    Topics: Amidohydrolases; Animals; Benzamides; Brain; Carbamates; Carbon Radioisotopes; Humans; Ligands; Mice; Molecular Structure; Piperazines; Positron-Emission Tomography; Radiopharmaceuticals; Rats; Thiazoles; Tissue Distribution

2016
The fatty acid amide hydrolase inhibitor URB597 modulates serotonin-dependent emotional behaviour, and serotonin1A and serotonin2A/C activity in the hippocampus.
    European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology, 2016, Volume: 26, Issue:3

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Action Potentials; Adrenergic Agents; Amidohydrolases; Animals; Benzamides; Benzoxazines; Benzylamines; Calcium Channel Blockers; Carbamates; Dose-Response Relationship, Drug; Emotions; Hippocampus; Immobility Response, Tonic; Locomotion; Male; Maze Learning; Morpholines; Naphthalenes; Rats; Rats, Sprague-Dawley; Receptors, Serotonin; Serotonergic Neurons; Serotonin; Serotonin Agents

2016
Self-administration of the anandamide transport inhibitor AM404 by squirrel monkeys.
    Psychopharmacology, 2016, Volume: 233, Issue:10

    Topics: Animals; Arachidonic Acids; Benzamides; Cannabinoid Receptor Antagonists; Carbamates; Cocaine; Dose-Response Relationship, Drug; Dronabinol; Drug-Seeking Behavior; Endocannabinoids; Male; Nicotine; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Reinforcement, Psychology; Reward; Rimonabant; Saimiri; Self Administration

2016
The effects anandamide signaling in the prelimbic cortex and basolateral amygdala on coping with environmental stimuli in rats.
    Psychopharmacology, 2016, Volume: 233, Issue:10

    Topics: Adaptation, Psychological; Animals; Anti-Anxiety Agents; Anxiety; Arachidonic Acids; Basolateral Nuclear Complex; Benzamides; Carbamates; Endocannabinoids; Glycerides; Male; Polyunsaturated Alkamides; Prefrontal Cortex; Rats; Rats, Wistar; Signal Transduction

2016
Comparisons of Δ9-Tetrahydrocannabinol and Anandamide on a Battery of Cognition-Related Behavior in Nonhuman Primates.
    The Journal of pharmacology and experimental therapeutics, 2016, Volume: 357, Issue:1

    Topics: Animals; Arachidonic Acids; Attention; Behavior, Animal; Benzamides; Carbamates; Cognition; Discrimination Learning; Dose-Response Relationship, Drug; Dronabinol; Endocannabinoids; Learning; Male; Memory, Short-Term; Motivation; Piperidines; Polyunsaturated Alkamides; Psychomotor Performance; Pyrazoles; Reversal Learning; Rimonabant; Saimiri

2016
Attenuation of cue-induced reinstatement of nicotine seeking by URB597 through cannabinoid CB1 receptor in rats.
    Psychopharmacology, 2016, Volume: 233, Issue:10

    Topics: Amidohydrolases; Animals; Arachidonic Acids; Benzamides; Cannabinoid Receptor Antagonists; Carbamates; Cues; Drug-Seeking Behavior; Endocannabinoids; Male; Nicotine; Piperidines; Polyunsaturated Alkamides; PPAR alpha; Pyrazoles; Rats; Rats, Long-Evans; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Rimonabant; Tobacco Use Disorder

2016
Age-specific influences of chronic administration of the fatty acid amide hydrolase inhibitor URB597 on cardiovascular parameters and organ hypertrophy in DOCA-salt hypertensive rats.
    Pharmacological reports : PR, 2016, Volume: 68, Issue:2

    Topics: Amidohydrolases; Animals; Benzamides; Blood Pressure; Carbamates; Desoxycorticosterone Acetate; Heart; Heart Rate; Hypertension; Hypertrophy; Kidney; Male; Rats; Rats, Wistar

2016
Sex differences in hippocampal response to endocannabinoids after exposure to severe stress.
    Hippocampus, 2016, Volume: 26, Issue:7

    Topics: Amidohydrolases; Amygdala; Animals; Benzamides; Carbamates; Disease Models, Animal; Endocannabinoids; Enzyme Inhibitors; Fear; Female; Hippocampus; Long-Term Potentiation; Male; Prefrontal Cortex; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Sex Characteristics; Stress Disorders, Post-Traumatic; Stress, Psychological

2016
Fatty acid amide hydrolase inhibitors confer anti-invasive and antimetastatic effects on lung cancer cells.
    Oncotarget, 2016, Mar-22, Volume: 7, Issue:12

    Topics: Aged; Amidohydrolases; Animals; Apoptosis; Arachidonic Acids; Benzamides; Biomarkers, Tumor; Brain Neoplasms; Carbamates; Carcinoma, Non-Small-Cell Lung; Cell Movement; Cell Proliferation; Female; Gene Expression Regulation, Enzymologic; Humans; Lung Neoplasms; Male; Mice; Mice, Nude; Neoplasm Invasiveness; Receptor, Cannabinoid, CB2; Serotonin; Tissue Inhibitor of Metalloproteinase-1; Tumor Cells, Cultured; Xenograft Model Antitumor Assays

2016
Encapsulation of cannabinoid drugs in nanostructured lipid carriers.
    European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 2016, Volume: 102

    Topics: Benzamides; Cannabinoids; Carbamates; Drug Carriers; Lipids; Nanostructures; Piperidines; Pyrazoles; Rimonabant

2016
Protective role of cannabinoid CB1 receptors and vascular effects of chronic administration of FAAH inhibitor URB597 in DOCA-salt hypertensive rats.
    Life sciences, 2016, Apr-15, Volume: 151

    Topics: Amidohydrolases; Animals; Aorta; Arachidonic Acids; Benzamides; Blood Pressure; Capsaicin; Carbamates; Desoxycorticosterone Acetate; Dose-Response Relationship, Drug; Drug Interactions; Hypertension; Male; Mesenteric Arteries; Morpholines; Phenylephrine; Pyrazoles; Rats; Receptor, Cannabinoid, CB1; Sodium Chloride; Vasoconstriction; Vasodilation

2016
Crosstalk between liver antioxidant and the endocannabinoid systems after chronic administration of the FAAH inhibitor, URB597, to hypertensive rats.
    Toxicology and applied pharmacology, 2016, 06-15, Volume: 301

    Topics: Amidohydrolases; Animals; Benzamides; Carbamates; Catalase; Desoxycorticosterone Acetate; Endocannabinoids; Glutathione; Glutathione Disulfide; Glutathione Peroxidase; Glutathione Transferase; Hypertension; Liver; Male; Monoacylglycerol Lipases; Phospholipases A2; Rats, Wistar; Reactive Oxygen Species; Receptor, Cannabinoid, CB1; Superoxide Dismutase

2016
Distinct neuronal activation patterns are associated with PCP-induced social withdrawal and its reversal by the endocannabinoid-enhancing drug URB597.
    Neuroscience research, 2016, Volume: 110

    Topics: Amidohydrolases; Animals; Benzamides; Brain; Carbamates; Endocannabinoids; Exploratory Behavior; Male; Neurons; Phencyclidine; Proto-Oncogene Proteins c-fos; Rats, Wistar; Schizophrenia; Schizophrenic Psychology; Social Behavior

2016
URB597 inhibits oxidative stress induced by alcohol binging in the prefrontal cortex of adolescent rats.
    Neuroscience letters, 2016, 06-15, Volume: 624

    Topics: Amidohydrolases; Animals; Benzamides; Binge Drinking; Carbamates; Ethanol; Male; Oxidative Stress; Prefrontal Cortex; Rats; Rats, Wistar

2016
Fatty acid amide hydrolase inhibition for the symptomatic relief of Parkinson's disease.
    Brain, behavior, and immunity, 2016, Volume: 57

    Topics: Amidohydrolases; Animals; Arachidonic Acids; Benzamides; Cannabinoid Receptor Agonists; Carbamates; Disease Models, Animal; Endocannabinoids; Male; Mice; Mice, Inbred C57BL; Parkinsonian Disorders; Polyunsaturated Alkamides; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2

2016
Cannabinoid receptor agonist WIN55,212-2 and fatty acid amide hydrolase inhibitor URB597 may protect against cognitive impairment in rats of chronic cerebral hypoperfusion via PI3K/AKT signaling.
    Behavioural brain research, 2016, 10-15, Volume: 313

    Topics: Animals; Benzamides; Benzoxazines; Cannabinoid Receptor Agonists; Carbamates; Cognitive Dysfunction; Fatty Acids; Glycogen Synthase Kinase 3; Long-Term Potentiation; Male; Maze Learning; Mixed Function Oxygenases; Morpholines; Naphthalenes; Neuroprotective Agents; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Rats, Sprague-Dawley; Receptors, Cannabinoid; Signal Transduction

2016
Involvement of endocannabinoid neurotransmission in the bed nucleus of stria terminalis in cardiovascular responses to acute restraint stress in rats.
    British journal of pharmacology, 2016, Volume: 173, Issue:19

    Topics: Acute Disease; Animals; Benzamides; Benzodioxoles; Carbamates; Cardiovascular System; Dose-Response Relationship, Drug; Endocannabinoids; Male; Piperidines; Pyrazoles; Rats; Rats, Wistar; Restraint, Physical; Septal Nuclei; Stress, Psychological; Structure-Activity Relationship; Synaptic Transmission

2016
Orchestrated activation of mGluR5 and CB1 promotes neuroprotection.
    Molecular brain, 2016, 08-20, Volume: 9, Issue:1

    Topics: Animals; Benzamides; Benzodioxoles; Calcium; Carbamates; Enzyme Activation; Extracellular Signal-Regulated MAP Kinases; Gene Knockdown Techniques; Intracellular Space; Mice, Inbred C57BL; Models, Biological; Neurons; Neuroprotection; Phosphorylation; Piperidines; Presynaptic Terminals; Proto-Oncogene Proteins c-akt; Pyrazoles; Receptor, Cannabinoid, CB1; Receptor, Metabotropic Glutamate 5; Synapses

2016
Emotional arousal state influences the ability of amygdalar endocannabinoid signaling to modulate anxiety.
    Neuropharmacology, 2016, Volume: 111

    Topics: Animals; Anxiety; Arachidonic Acids; Arousal; Basolateral Nuclear Complex; Benzamides; Cannabinoid Receptor Agonists; Carbamates; Corticosterone; Emotions; Endocannabinoids; Epinephrine; Glycerides; Male; Polyunsaturated Alkamides; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Signal Transduction

2016
Chronic FAAH inhibition during nicotine abstinence alters habenular CB1 receptor activity and precipitates depressive-like behaviors.
    Neuropharmacology, 2017, Volume: 113, Issue:Pt A

    Topics: Amidohydrolases; Animals; Benzamides; Carbamates; Depression; Habenula; Male; Nicotine; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Self Administration; Substance Withdrawal Syndrome

2017
Chronic stress leads to epigenetic dysregulation in the neuropeptide-Y and cannabinoid CB1 receptor genes in the mouse cingulate cortex.
    Neuropharmacology, 2017, Volume: 113, Issue:Pt A

    Topics: Animals; Benzamides; Carbamates; Epigenesis, Genetic; Gyrus Cinguli; Humans; Male; Mice; Mice, Inbred C57BL; Neuropeptide Y; Receptor, Cannabinoid, CB1; Stress, Psychological

2017
Effects of alprazolam and cannabinoid-related compounds in an animal model of panic attack.
    Behavioural brain research, 2017, 01-15, Volume: 317

    Topics: Alprazolam; Analgesics; Animals; Arachidonic Acids; Benzamides; Benzoxazines; Blood Pressure; Cannabinoids; Carbamates; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme Inhibitors; Escape Reaction; Heart Rate; Hypnotics and Sedatives; Locomotion; Male; Mice; Morpholines; Naphthalenes; Panic Disorder; Potassium Cyanide; Rats, Wistar; Serotonin

2017
URB597 improves cognitive impairment induced by chronic cerebral hypoperfusion by inhibiting mTOR-dependent autophagy.
    Neuroscience, 2017, 03-06, Volume: 344

    Topics: Amidohydrolases; Animals; Apoptosis; Autophagy; Benzamides; CA1 Region, Hippocampal; Carbamates; Carotid Artery, Common; Cerebrovascular Disorders; Cognition; Cognitive Dysfunction; Disease Models, Animal; Long-Term Potentiation; Male; Maze Learning; Neurons; Neuroprotective Agents; Nootropic Agents; Phosphorylation; Rats, Sprague-Dawley; TOR Serine-Threonine Kinases

2017
URB597 and the Cannabinoid WIN55,212-2 Reduce Behavioral and Neurochemical Deficits Induced by MPTP in Mice: Possible Role of Redox Modulation and NMDA Receptors.
    Neurotoxicity research, 2017, Volume: 31, Issue:4

    Topics: Animals; Benzamides; Benzoxazines; Carbamates; Corpus Striatum; Dopamine; Down-Regulation; Lipid Peroxidation; Locomotion; Male; Mice; Morpholines; MPTP Poisoning; Naphthalenes; Oxidation-Reduction; Protein Carbonylation; Receptors, N-Methyl-D-Aspartate; Substantia Nigra; Tyrosine 3-Monooxygenase

2017
Effect of inhibition of fatty acid amide hydrolase on MPTP-induced dopaminergic neuronal damage.
    Neurologia, 2019, Volume: 34, Issue:3

    Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Amidohydrolases; Animals; Benzamides; Carbamates; Disease Models, Animal; Dopaminergic Neurons; Male; Mice; Mice, Inbred C57BL; Motor Skills; Neuroprotective Agents; Parkinson Disease; Substantia Nigra; Tyrosine 3-Monooxygenase

2019
URB597 reduces biochemical, behavioral and morphological alterations in two neurotoxic models in rats.
    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2017, Volume: 88

    Topics: Amidohydrolases; Animals; Apomorphine; Behavior, Animal; Benzamides; Body Weight; Carbamates; Injections; Lipid Peroxidation; Male; Motor Skills; Neostriatum; Neuroprotective Agents; Neurotoxicity Syndromes; Nitro Compounds; Oxidopamine; Propionates; Rats; Rats, Wistar

2017
Fatty acid amide hydrolase inhibitors produce rapid anti-anxiety responses through amygdala long-term depression in male rodents.
    Journal of psychiatry & neuroscience : JPN, 2017, Volume: 42, Issue:4

    Topics: Amidohydrolases; Amygdala; Animals; Anti-Anxiety Agents; Benzamides; Carbamates; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Long-Term Synaptic Depression; Male; Mutation; Piperidines; Pyridines; Rats; Receptor, Cannabinoid, CB1

2017
The role of CB
    FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2017, Volume: 31, Issue:8

    Topics: Amidohydrolases; Arachidonic Acids; Benzamides; Benzodioxoles; Caco-2 Cells; Carbamates; Colorectal Neoplasms; Cytokines; Electric Impedance; Endocannabinoids; Gene Expression Regulation; Glycerides; Humans; Inflammation; Intestinal Mucosa; Intestines; Monoacylglycerol Lipases; Oxygen Consumption; Permeability; Piperidines; Polyunsaturated Alkamides; Receptor, Cannabinoid, CB1; Tissue Culture Techniques

2017
Chronic inhibition of fatty acid amide hydrolase by URB597 produces differential effects on cardiac performance in normotensive and hypertensive rats.
    British journal of pharmacology, 2017, Volume: 174, Issue:13

    Topics: Amidohydrolases; Animals; Antihypertensive Agents; Benzamides; Blood Pressure; Carbamates; Cyclohexanols; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme Inhibitors; Heart; Isoproterenol; Male; Myocardial Contraction; Rats; Rats, Inbred SHR; Rats, Wistar; Structure-Activity Relationship

2017
Inhibition of SENP3 by URB597 ameliorates neurovascular unit dysfunction in rats with chronic cerebral hypoperfusion.
    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2017, Volume: 91

    Topics: Animals; Apoptosis; Benzamides; Brain; Brain Ischemia; Carbamates; Chronic Disease; Disease Models, Animal; Endopeptidases; Male; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Up-Regulation

2017
Lipid nanoparticles for administration of poorly water soluble neuroactive drugs.
    Biomedical microdevices, 2017, Volume: 19, Issue:3

    Topics: Animals; Benzamides; Brain; Carbamates; Drug Carriers; Drug Liberation; Glycerides; Kinetics; Lipids; Male; Nanoparticles; Particle Size; Polysorbates; Rats; Rats, Wistar; Solubility; Tissue Distribution; Triglycerides; Water

2017
Early blockade of joint inflammation with a fatty acid amide hydrolase inhibitor decreases end-stage osteoarthritis pain and peripheral neuropathy in mice.
    Arthritis research & therapy, 2017, 05-25, Volume: 19, Issue:1

    Topics: Amidohydrolases; Animals; Arthralgia; Benzamides; Carbamates; Inflammation; Knee Joint; Male; Mice; Mice, Inbred C57BL; Osteoarthritis; Peripheral Nervous System Diseases

2017
Sensitization of C-fiber nociceptors in mice with sickle cell disease is decreased by local inhibition of anandamide hydrolysis.
    Pain, 2017, Volume: 158, Issue:9

    Topics: Anemia, Sickle Cell; Animals; Arachidonic Acids; Benzamides; Carbamates; Disease Models, Animal; Endocannabinoids; Enzyme Inhibitors; Evoked Potentials; Hemoglobins; Humans; Hydrolysis; Hyperalgesia; Indoles; Male; Mice; Mice, Transgenic; Morpholines; Nerve Fibers, Unmyelinated; Nociceptors; Pain Threshold; Polyunsaturated Alkamides; Pyrazoles; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2

2017
The effects of chronic FAAH inhibition on myocardial lipid metabolism in normotensive and DOCA-salt hypertensive rats.
    Life sciences, 2017, Aug-15, Volume: 183

    Topics: Amidohydrolases; Animals; Benzamides; Blood Pressure; Carbamates; Chromatography, Gas; Chromatography, Liquid; Coronary Vessels; Desoxycorticosterone Acetate; Disease Models, Animal; Endocannabinoids; Fatty Acids; Hypertension; Lipid Metabolism; Male; Myocardium; Myocytes, Cardiac; Rats; Rats, Wistar

2017
The effects of enhancing endocannabinoid signaling and blocking corticotrophin releasing factor receptor in the amygdala and hippocampus on the consolidation of a stressful event.
    European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology, 2017, Volume: 27, Issue:9

    Topics: Amidohydrolases; Animals; Anxiety; Basolateral Nuclear Complex; Benzamides; CA1 Region, Hippocampal; Carbamates; Disease Models, Animal; Endocannabinoids; Male; Memory Consolidation; Nootropic Agents; Pyrimidines; Pyrroles; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Receptors, Corticotropin-Releasing Hormone; Reflex, Startle; RNA, Messenger; Stress Disorders, Post-Traumatic; Stress, Psychological

2017
Cannabinoids prevent the differential long-term effects of exposure to severe stress on hippocampal- and amygdala-dependent memory and plasticity.
    Hippocampus, 2017, Volume: 27, Issue:10

    Topics: Amidohydrolases; Amygdala; Animals; Avoidance Learning; Benzamides; Benzoxazines; Bromine; Cannabinoid Receptor Modulators; Cannabinoids; Carbamates; Disease Models, Animal; Drug Combinations; Electroshock; Enzyme Inhibitors; Fear; Glutamates; Hippocampus; Magnesium; Male; Memory; Morpholines; Naphthalenes; Neuronal Plasticity; Piperidines; Pyrazoles; Rats, Sprague-Dawley; Receptors, Cannabinoid; Stress Disorders, Post-Traumatic

2017
Blockade of alcohol escalation and "relapse" drinking by pharmacological FAAH inhibition in male and female C57BL/6J mice.
    Psychopharmacology, 2017, Volume: 234, Issue:19

    Topics: Alcohol Drinking; Alcoholism; Amidohydrolases; Animals; Benzamides; Carbamates; Endocannabinoids; Ethanol; Male; Mice; Mice, Inbred C57BL; Random Allocation; Receptor, Cannabinoid, CB1; Recurrence

2017
Effect of footshock stress on place conditioning produced by Δ
    Psychopharmacology, 2017, Volume: 234, Issue:21

    Topics: Affect; Animals; Arousal; Avoidance Learning; Benzamides; Carbamates; Conditioning, Classical; Dose-Response Relationship, Drug; Dronabinol; Electroshock; Male; Rats; Rats, Sprague-Dawley; Reward; Stress, Psychological

2017
Activation of Endocannabinoid Receptor 2 as a Mechanism of Propofol Pretreatment-Induced Cardioprotection against Ischemia-Reperfusion Injury in Rats.
    Oxidative medicine and cellular longevity, 2017, Volume: 2017

    Topics: Animals; Apoptosis; Arachidonic Acids; Benzamides; Carbamates; Cells, Cultured; Endocannabinoids; Indoles; Male; Malondialdehyde; Myocardial Reperfusion Injury; Myocytes, Cardiac; Pentobarbital; Peroxidase; Propofol; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Signal Transduction; Superoxide Dismutase

2017
Cannabinoid receptor agonist WIN55,212-2 and fatty acid amide hydrolase inhibitor URB597 ameliorate neuroinflammatory responses in chronic cerebral hypoperfusion model by blocking NF-κB pathways.
    Naunyn-Schmiedeberg's archives of pharmacology, 2017, Volume: 390, Issue:12

    Topics: Amidohydrolases; Animals; Anti-Inflammatory Agents; Benzamides; Benzoxazines; Cannabinoid Receptor Agonists; Carbamates; Cerebrovascular Disorders; Endocannabinoids; Hippocampus; Macrophage Activation; Male; Morpholines; Naphthalenes; Neuritis; NF-kappa B; Prefrontal Cortex; Rats; Rats, Sprague-Dawley; Signal Transduction; Transcription Factor RelA

2017
Enhanced anandamide signaling reduces flight behavior elicited by an approaching robo-beetle.
    Neuropharmacology, 2017, Volume: 126

    Topics: Amidohydrolases; Animals; Anti-Anxiety Agents; Anxiety; Arachidonic Acids; Avoidance Learning; Behavior, Animal; Benzamides; Benzodioxoles; Cannabinoid Receptor Agonists; Carbamates; Diazepam; Endocannabinoids; Fear; Male; Mice, Inbred C57BL; Monoacylglycerol Lipases; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant

2017
The FAAH inhibitor URB597 suppresses hippocampal maximal dentate afterdischarges and restores seizure-induced impairment of short and long-term synaptic plasticity.
    Scientific reports, 2017, 09-11, Volume: 7, Issue:1

    Topics: Amidohydrolases; Animals; Benzamides; Cannabinoids; Carbamates; Dentate Gyrus; Long-Term Potentiation; Male; Neuronal Plasticity; Rats; Seizures; Synaptic Transmission

2017
Fatty acid amide hydrolase inhibitor URB597 may protect against kainic acid-induced damage to hippocampal neurons: Dependence on the degree of injury.
    Epilepsy research, 2017, Volume: 137

    Topics: Amidohydrolases; Animals; Benzamides; Carbamates; Cell Death; Cell Nucleus; Cell Survival; Disease Models, Animal; Endoplasmic Reticulum; Enzyme Inhibitors; Hippocampus; Kainic Acid; Microscopy, Electron; Mitochondria; Neurons; Neuroprotective Agents; Rats, Wistar; Severity of Illness Index; Status Epilepticus

2017
Inhibition of fatty acid amide hydrolase in the central amygdala alleviates co-morbid expression of innate anxiety and excessive alcohol intake.
    Addiction biology, 2018, Volume: 23, Issue:6

    Topics: Alcoholism; Amidohydrolases; Analysis of Variance; Animals; Anxiety Disorders; Benzamides; Carbamates; Central Amygdaloid Nucleus; Central Nervous System Depressants; Conditioning, Operant; Enzyme Inhibitors; Ethanol; Male; Maze Learning; Microinjections; Rats, Inbred Strains; Rats, Wistar; Restraint, Physical; Self Administration; Stress, Psychological

2018
The cannabinoid transporter inhibitor OMDM-2 reduces social interaction: Further evidence for transporter-mediated endocannabinoid release.
    Neuropharmacology, 2018, 03-01, Volume: 130

    Topics: Amidohydrolases; Amygdala; Animals; Arachidonic Acids; Behavior, Animal; Benzamides; Benzodioxoles; Benzyl Compounds; Cannabinoid Receptor Modulators; Carbamates; Endocannabinoids; Male; Piperidines; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Social Behavior

2018
Redox system and phospholipid metabolism in the kidney of hypertensive rats after FAAH inhibitor URB597 administration.
    Redox biology, 2018, Volume: 15

    Topics: Amidohydrolases; Animals; Benzamides; Blood Pressure; Carbamates; Humans; Hypertension, Renal; Kidney; Oxidation-Reduction; Phospholipids; Rats; Rats, Inbred SHR; Reactive Oxygen Species; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2

2018
Enhancing Endocannabinoid Neurotransmission Augments The Efficacy of Extinction Training and Ameliorates Traumatic Stress-Induced Behavioral Alterations in Rats.
    Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2018, Volume: 43, Issue:6

    Topics: Amidohydrolases; Animals; Arachidonic Acids; Benzamides; Benzodioxoles; Benzoxazines; Cannabinoid Receptor Modulators; Carbamates; Disease Models, Animal; Electroshock; Endocannabinoids; Extinction, Psychological; Glycerides; Male; Morpholines; Naphthalenes; Piperidines; Psychotropic Drugs; Rats, Sprague-Dawley; Social Isolation; Stress Disorders, Post-Traumatic; Synaptic Transmission

2018
Modulation of central endocannabinoid system results in gastric mucosal protection in the rat.
    Brain research bulletin, 2018, Volume: 139

    Topics: Analysis of Variance; Animals; Arachidonic Acids; Benzamides; Benzodioxoles; Calcitonin Gene-Related Peptide; Carbamates; Catalepsy; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Routes; Endocannabinoids; Ethanol; Gastric Mucosa; Gastrointestinal Motility; Hypothermia; Male; Piperidines; Rats; Rats, Wistar; Somatostatin; Stomach Diseases; Superoxide Dismutase

2018
Cannabinoids prevent depressive-like symptoms and alterations in BDNF expression in a rat model of PTSD.
    Progress in neuro-psychopharmacology & biological psychiatry, 2018, 06-08, Volume: 84, Issue:Pt A

    Topics: Amidohydrolases; Animals; Benzamides; Benzoxazines; Brain-Derived Neurotrophic Factor; Cannabinoid Receptor Agonists; Cannabinoids; Carbamates; Depression; Disease Models, Animal; Electroshock; Enzyme Inhibitors; Gene Expression; Hippocampus; Male; Morpholines; Naphthalenes; Prefrontal Cortex; Rats, Sprague-Dawley; Stress Disorders, Post-Traumatic

2018
Chronic treatment with URB597 ameliorates post-stress symptoms in a rat model of PTSD.
    European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology, 2018, Volume: 28, Issue:5

    Topics: Amidohydrolases; Animals; Arachidonic Acids; Basolateral Nuclear Complex; Benzamides; Benzoxazines; CA1 Region, Hippocampal; Cannabinoid Receptor Antagonists; Carbamates; Dose-Response Relationship, Drug; Electric Stimulation; Endocannabinoids; Extinction, Psychological; Glycerides; Male; Morpholines; Naphthalenes; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rats; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Reflex, Startle; Stress Disorders, Post-Traumatic

2018
The Endocannabinoid System Affects Myocardial Glucose Metabolism in the DOCA-Salt Model of Hypertension.
    Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 2018, Volume: 46, Issue:2

    Topics: Animals; Benzamides; Blood Glucose; Carbamates; Desoxycorticosterone Acetate; Glucose; Glucose Transporter Type 1; Glucose Transporter Type 4; Glycogen; Hypertension; Insulin; Ketone Oxidoreductases; Male; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Myocardium; Phosphorylation; Proto-Oncogene Proteins c-akt; Rats; Rats, Wistar

2018
Examination of the effects of cannabinoid ligands on decision making in a rat gambling task.
    Pharmacology, biochemistry, and behavior, 2018, Volume: 170

    Topics: Animals; Benzamides; Benzoxazines; Carbamates; Decision Making; Dronabinol; Endocannabinoids; Gambling; Impulsive Behavior; Ligands; Male; Morpholines; Naphthalenes; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Rimonabant; Task Performance and Analysis

2018
The prefrontal cortical endocannabinoid system modulates fear-pain interactions in a subregion-specific manner.
    British journal of pharmacology, 2019, Volume: 176, Issue:10

    Topics: Animals; Behavior, Animal; Benzamides; Cannabinoid Receptor Modulators; Carbamates; Conditioning, Psychological; Endocannabinoids; Fear; Pain; Pain Measurement; Piperidines; Prefrontal Cortex; Pyrazoles; Rats

2019
Inhibition of Fatty Acid Amide Hydrolase Improves Depressive-Like Behaviors Independent of Its Peripheral Antinociceptive Effects in a Rat Model of Neuropathic Pain.
    Anesthesia and analgesia, 2019, Volume: 129, Issue:2

    Topics: Amidohydrolases; Animals; Arachidonic Acids; Behavior, Animal; Benzamides; Carbamates; Depression; Disease Models, Animal; Endocannabinoids; Enzyme Inhibitors; Feeding Behavior; Glycerides; Hippocampus; Locomotion; Male; Neuralgia; Neurogenesis; Pain Threshold; Polyunsaturated Alkamides; Rats, Wistar; Receptor, Cannabinoid, CB1; Signal Transduction; Swimming

2019
Sub-chronic treatment with cannabidiol but not with URB597 induced a mild antidepressant-like effect in diabetic rats.
    Neuroscience letters, 2018, 08-24, Volume: 682

    Topics: Animals; Antidepressive Agents; Benzamides; Cannabidiol; Carbamates; Depression; Diabetes Mellitus, Experimental; Dose-Response Relationship, Drug; Male; Rats; Rats, Wistar; Swimming

2018
FAAH inhibition attenuates TLR3-mediated hyperthermia, nociceptive- and anxiety-like behaviour in female rats.
    Behavioural brain research, 2018, 11-01, Volume: 353

    Topics: Amidohydrolases; Animals; Anxiety; Benzamides; Carbamates; Central Nervous System Agents; Enzyme Inhibitors; Fever; Hypothalamus; Inflammation; Macrophages; Microglia; Nociceptive Pain; Random Allocation; Rats; Rats, Sprague-Dawley; Toll-Like Receptor 3

2018
Inhibition of excessive autophagy and mitophagy mediates neuroprotective effects of URB597 against chronic cerebral hypoperfusion.
    Cell death & disease, 2018, 06-28, Volume: 9, Issue:7

    Topics: Adenylate Kinase; Animals; Autophagosomes; Autophagy; Beclin-1; Benzamides; Brain Ischemia; Carbamates; Hippocampus; Lysosomes; Male; Membrane Fusion; Mitochondria; Mitophagy; Neurons; Neuroprotective Agents; Phosphorylation; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-bcl-2; Rats, Sprague-Dawley; Synapses; TOR Serine-Threonine Kinases

2018
Role of endocannabinoids in the hippocampus and amygdala in emotional memory and plasticity.
    Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2018, Volume: 43, Issue:10

    Topics: Amidohydrolases; Amygdala; Animals; Benzamides; CA1 Region, Hippocampal; Carbamates; Electroshock; Emotions; Endocannabinoids; Extinction, Psychological; Fear; Hippocampus; Long-Term Potentiation; Male; Memory; Microinjections; Neuronal Plasticity; Rats; Rats, Sprague-Dawley

2018
Adult Cellular Neuroadaptations Induced by Adolescent THC Exposure in Female Rats Are Rescued by Enhancing Anandamide Signaling.
    The international journal of neuropsychopharmacology, 2018, 11-01, Volume: 21, Issue:11

    Topics: Adaptation, Psychological; Animals; Arachidonic Acids; Benzamides; Carbamates; Dentate Gyrus; Depression; Dronabinol; Endocannabinoids; Female; Marijuana Abuse; Neurogenesis; Neuronal Plasticity; Polyunsaturated Alkamides; Prefrontal Cortex; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Sexual Maturation; Signal Transduction; Synapses; Tissue Culture Techniques

2018
Pharmacological blockade of fatty acid amide hydrolase (FAAH) by URB597 improves memory and changes the phenotype of hippocampal microglia despite ethanol exposure.
    Biochemical pharmacology, 2018, Volume: 157

    Topics: Amidohydrolases; Animals; Arachidonic Acids; Benzamides; Carbamates; Chemokines; Cytokines; Dentate Gyrus; Endocannabinoids; Enzyme Inhibitors; Ethanol; Gene Expression; Glial Fibrillary Acidic Protein; Hippocampus; Male; Memory; Memory, Long-Term; Memory, Short-Term; Microglia; Nitric Oxide Synthase Type II; Phenotype; Polyunsaturated Alkamides; Rats, Wistar; Receptors, Chemokine

2018
Hypertension and chronic inhibition of endocannabinoid degradation modify the endocannabinoid system and redox balance in rat heart and plasma.
    Prostaglandins & other lipid mediators, 2018, Volume: 138

    Topics: Amidohydrolases; Animals; Arachidonic Acids; Benzamides; Carbamates; Desoxycorticosterone Acetate; Endocannabinoids; Glycerides; Heart; Hypertension; Male; Myocardium; Oxidation-Reduction; Oxidative Stress; Polyunsaturated Alkamides; Rats, Inbred SHR; Rats, Wistar; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2

2018
The Effect of Long-Term Administration of Fatty Acid Amide Hydrolase Inhibitor URB597 on Oxidative Metabolism in the Heart of Rats with Primary and Secondary Hypertension.
    Molecules (Basel, Switzerland), 2018, Sep-14, Volume: 23, Issue:9

    Topics: Amidohydrolases; Animals; Benzamides; Carbamates; Desoxycorticosterone Acetate; Disease Models, Animal; Gene Expression Regulation; Heart; Hypertension; Injections, Intraperitoneal; Male; NF-E2-Related Factor 2; Oxidative Stress; Rats; Xanthine Oxidase

2018
Long-term administration of fatty acid amide hydrolase inhibitor (URB597) to rats with spontaneous hypertension disturbs liver redox balance and phospholipid metabolism.
    Advances in medical sciences, 2019, Volume: 64, Issue:1

    Topics: Amidohydrolases; Animals; Benzamides; Carbamates; Endocannabinoids; Enzyme Inhibitors; Fatty Acids; Hypertension; Lipid Metabolism; Male; NF-kappa B; Oxidation-Reduction; Phospholipids; Rats; Reactive Oxygen Species; Tumor Necrosis Factor-alpha

2019
Brain-Permeant and -Impermeant Inhibitors of Fatty Acid Amide Hydrolase Synergize with the Opioid Analgesic Morphine to Suppress Chemotherapy-Induced Neuropathic Nociception Without Enhancing Effects of Morphine on Gastrointestinal Transit.
    The Journal of pharmacology and experimental therapeutics, 2018, Volume: 367, Issue:3

    Topics: Amidohydrolases; Analgesics, Opioid; Animals; Antineoplastic Agents; Arachidonic Acids; Benzamides; Brain; Cannabinoids; Carbamates; Gastrointestinal Transit; Hyperalgesia; Indoles; Mice; Mice, Inbred C57BL; Morphine; Morpholines; Neuralgia; Nociception; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2

2018
Endocannabinoid interactions in the regulation of acquisition of contextual conditioned fear.
    Progress in neuro-psychopharmacology & biological psychiatry, 2019, 03-02, Volume: 90

    Topics: Animals; Arachidonic Acids; Benzamides; Benzodioxoles; Brain; Carbamates; Central Nervous System Agents; Conditioning, Psychological; Endocannabinoids; Fear; Glycerides; Male; Motor Activity; Nociception; Piperidines; Polyunsaturated Alkamides; Random Allocation; Rats, Wistar

2019
Inhibition of Monoacylglycerol Lipase Reduces the Reinstatement of Methamphetamine-Seeking and Anxiety-Like Behaviors in Methamphetamine Self-Administered Rats.
    The international journal of neuropsychopharmacology, 2019, 02-01, Volume: 22, Issue:2

    Topics: Amidohydrolases; Amphetamine-Related Disorders; Animals; Anti-Anxiety Agents; Anxiety; Behavior, Addictive; Behavior, Animal; Benzamides; Benzodioxoles; Cannabinoid Receptor Antagonists; Carbamates; Central Nervous System Stimulants; Male; Maze Learning; Methamphetamine; Monoacylglycerol Lipases; Piperidines; Rats; Rats, Wistar

2019
Changes in physicochemical properties of kidney cells membrane as a consequence of hypertension and treatment of hypertensive rats with FAAH inhibitor.
    Chemico-biological interactions, 2019, Feb-01, Volume: 299

    Topics: Amidohydrolases; Animals; Benzamides; Carbamates; Cell Membrane; Chromatography, High Pressure Liquid; Desoxycorticosterone Acetate; Disease Models, Animal; Enzyme Inhibitors; Hypertension; Kidney; Lipid Peroxidation; Male; N-Acetylneuraminic Acid; Phospholipids; Rats; Rats, Inbred SHR; Rats, Wistar

2019
Fatty acid amide hydrolase inhibitor (URB597) as a regulator of myocardial lipid metabolism in spontaneously hypertensive rats.
    Chemistry and physics of lipids, 2019, Volume: 218

    Topics: Amidohydrolases; Animals; Benzamides; Carbamates; Enzyme Inhibitors; Lipid Metabolism; Myocardium; Rats; Rats, Inbred SHR; Rats, Inbred WKY

2019
Anandamide Reduces the Toxic Synergism Exerted by Quinolinic Acid and Glutaric Acid in Rat Brain Neuronal Cells.
    Neuroscience, 2019, 03-01, Volume: 401

    Topics: Animals; Arachidonic Acids; Benzamides; Cannabinoid Receptor Agonists; Carbamates; Cell Survival; Cells, Cultured; Cerebral Cortex; Drug Synergism; Endocannabinoids; Female; Glutarates; Male; Neurons; Piperidines; Polyunsaturated Alkamides; Pregnancy; Pyrazoles; Quinolinic Acid; Rats; Rats, Inbred WF; Receptors, Cannabinoid

2019
Hypothalamic endocannabinoid signalling modulates aversive responses related to panic attacks.
    Neuropharmacology, 2019, Volume: 148

    Topics: Animals; Arachidonic Acids; Benzamides; Biphenyl Compounds; Blood Pressure; Cannabinoids; Carbamates; Corticosterone; Dorsomedial Hypothalamic Nucleus; Endocannabinoids; Indoles; Male; Microinjections; N-Methylaspartate; Panic Disorder; Piperidines; Pyrazoles; Rats

2019
Brain permeant and impermeant inhibitors of fatty-acid amide hydrolase suppress the development and maintenance of paclitaxel-induced neuropathic pain without producing tolerance or physical dependence in vivo and synergize with paclitaxel to reduce tumor
    Pharmacological research, 2019, Volume: 142

    Topics: Amidohydrolases; Analgesics; Animals; Antineoplastic Agents; Benzamides; Benzoxazines; Brain; Cannabinoids; Carbamates; Cell Line, Tumor; Cell Survival; Drug Synergism; Drug Tolerance; HEK293 Cells; Humans; Hyperalgesia; Male; Mice; Mice, Inbred C57BL; Morpholines; Naphthalenes; Neuralgia; Paclitaxel; Substance-Related Disorders

2019
Role of the endocannabinoid system in the dorsal hippocampus in the cardiovascular changes and delayed anxiety-like effect induced by acute restraint stress in rats.
    Journal of psychopharmacology (Oxford, England), 2019, Volume: 33, Issue:5

    Topics: Amidohydrolases; Animals; Anxiety; Arachidonic Acids; Arterial Pressure; Behavior, Animal; Benzamides; Cannabinoid Receptor Agonists; Cannabinoid Receptor Antagonists; Carbamates; Disease Models, Animal; Endocannabinoids; Heart Rate; Hippocampus; Male; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Restraint, Physical; Skin Temperature; Stress, Psychological

2019
Effects of Fatty Acid Amide Hydrolase Inhibitors Acute Administration on the Positive and Cognitive Symptoms of Schizophrenia in Mice.
    Molecular neurobiology, 2019, Volume: 56, Issue:11

    Topics: Amidohydrolases; Animals; Avoidance Learning; Benzamides; Benzodioxoles; Carbamates; Cognition; Dizocilpine Maleate; Enzyme Inhibitors; Injections; Male; Memory; Mice; Motor Activity; Piperidines; Schizophrenia

2019
Anti-Inflammatory Effects by Pharmacological Inhibition or Knockdown of Fatty Acid Amide Hydrolase in BV2 Microglial Cells.
    Cells, 2019, 05-22, Volume: 8, Issue:5

    Topics: Amidohydrolases; Animals; Anti-Inflammatory Agents; Benzamides; Carbamates; Cell Line; Cyclooxygenase 2; Cytokines; Dinoprostone; Gene Knockdown Techniques; Inflammation; Microglia; Piperidines; Pyridines

2019
Antinociceptive and antidepressive efficacies of the combined ineffective doses of S-ketamine and URB597.
    Naunyn-Schmiedeberg's archives of pharmacology, 2019, Volume: 392, Issue:11

    Topics: Amidohydrolases; Analgesics; Animals; Antidepressive Agents; Behavior, Animal; Benzamides; Carbamates; Dose-Response Relationship, Drug; Drug Synergism; Ketamine; Male; Mice, Inbred Strains; Motor Activity; Nociceptive Pain; Receptors, N-Methyl-D-Aspartate; Swimming

2019
Anandamide modulation of circadian- and stress-dependent effects on rat short-term memory.
    Psychoneuroendocrinology, 2019, Volume: 108

    Topics: Animals; Arachidonic Acids; Arousal; Benzamides; Carbamates; Circadian Rhythm; Corticosterone; Emotions; Endocannabinoids; Male; Memory, Short-Term; Polyunsaturated Alkamides; Rats; Rats, Sprague-Dawley; Stress, Psychological

2019
URB597 ameliorates the deleterious effects induced by binge alcohol consumption in adolescent rats.
    Neuroscience letters, 2019, 10-15, Volume: 711

    Topics: Aging; Amidohydrolases; Animals; Benzamides; Binge Drinking; Brain; Brain-Derived Neurotrophic Factor; Carbamates; Cytokines; Male; Rats; Rats, Wistar

2019
Targeting the inhibition of fatty acid amide hydrolase ameliorate the endocannabinoid-mediated synaptic dysfunction in a valproic acid-induced rat model of Autism.
    Neuropharmacology, 2020, 01-01, Volume: 162

    Topics: Amidohydrolases; Animals; Arachidonic Acids; Autism Spectrum Disorder; Benzamides; Carbamates; Disease Models, Animal; Endocannabinoids; Enzyme Inhibitors; Female; Long-Term Synaptic Depression; Neuronal Plasticity; Polyunsaturated Alkamides; Prefrontal Cortex; Pregnancy; Prenatal Exposure Delayed Effects; Protein Transport; Rats; Receptors, AMPA; Receptors, Metabotropic Glutamate; Social Behavior; Valproic Acid

2020
Different Routes to Inhibit Fatty Acid Amide Hydrolase: Do All Roads Lead to the Same Place?
    International journal of molecular sciences, 2019, Sep-11, Volume: 20, Issue:18

    Topics: Amidohydrolases; Animals; Benzamides; Carbamates; Cerebellum; Endocannabinoids; Enzyme Inhibitors; Hippocampus; Liver; Male; Mice, Inbred C57BL; Pyridazines; Urea

2019
Adaptive mechanisms following antidepressant drugs: Focus on serotonin 5-HT
    Pharmacological reports : PR, 2019, Volume: 71, Issue:6

    Topics: Acetylcysteine; Animals; Antidepressive Agents; Autoradiography; Benzamides; Brain; Carbamates; Citalopram; Imipramine; Ketanserin; Male; Nucleus Accumbens; Rats; Rats, Wistar; Receptor, Serotonin, 5-HT2A; Thiazepines

2019
Neuropeptide Y and cannabinoids interaction in the amygdala after exposure to shock and reminders model of PTSD.
    Neuropharmacology, 2020, 01-01, Volume: 162

    Topics: Amygdala; Animals; Arachidonic Acids; Arousal; Basolateral Nuclear Complex; Behavior, Animal; Benzamides; Carbamates; Depression; Disease Models, Animal; Endocannabinoids; Extinction, Psychological; Neuropeptide Y; Polyunsaturated Alkamides; Rats; Receptor, Cannabinoid, CB1; Receptors, Neuropeptide Y; Reflex, Startle; Social Behavior; Stress Disorders, Post-Traumatic

2020
FAAH inhibition as a preventive treatment for migraine: A pre-clinical study.
    Neurobiology of disease, 2020, Volume: 134

    Topics: Amidohydrolases; Animals; Benzamides; Carbamates; Disease Models, Animal; Male; Migraine Disorders; Nitroglycerin; Rats; Rats, Sprague-Dawley; Trigeminal Caudal Nucleus; Vasodilator Agents

2020
Cannabidiol increases the nociceptive threshold in a preclinical model of Parkinson's disease.
    Neuropharmacology, 2020, Volume: 163

    Topics: Amidohydrolases; Analgesics; Animals; Benzamides; Brain; Cannabidiol; Capsaicin; Carbamates; Celecoxib; Hyperalgesia; Male; Mice; Mice, Inbred C57BL; Morphine; Nociception; Oxidopamine; Pain; Parkinson Disease; Piperidines; Pyrazoles; Thienamycins

2020
URB597 protects against NLRP3 inflammasome activation by inhibiting autophagy dysfunction in a rat model of chronic cerebral hypoperfusion.
    Journal of neuroinflammation, 2019, Dec-09, Volume: 16, Issue:1

    Topics: Animals; Autophagy; Benzamides; Brain Ischemia; Carbamates; Disease Models, Animal; Hippocampus; Inflammasomes; Male; Neuroprotective Agents; NLR Family, Pyrin Domain-Containing 3 Protein; Random Allocation; Rats; Rats, Sprague-Dawley

2019
Endocannabinoid degradation inhibitors ameliorate neuronal and synaptic alterations following traumatic brain injury.
    Journal of neurophysiology, 2020, 02-01, Volume: 123, Issue:2

    Topics: Amidohydrolases; Animals; Benzamides; Benzodioxoles; Brain Injuries, Traumatic; Carbamates; Electrophysiological Phenomena; Endocannabinoids; Enzyme Inhibitors; Excitatory Postsynaptic Potentials; Machine Learning; Male; Monoacylglycerol Lipases; Piperazines; Piperidines; Pyramidal Cells; Rats; Rats, Wistar; Sensorimotor Cortex; Succinimides

2020
Endocannabinoid modulating drugs improve anxiety but not the expression of conditioned fear in a rodent model of post-traumatic stress disorder.
    Neuropharmacology, 2020, Volume: 166

    Topics: Animals; Anxiety; Benzamides; Benzoxazines; Carbamates; Conditioning, Psychological; Disease Models, Animal; Endocannabinoids; Fear; Male; Morpholines; Naphthalenes; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Rodentia; Stress Disorders, Post-Traumatic

2020
Effects of hypertension and FAAH inhibitor treatment of rats with primary and secondary hypertension considering the physicochemical properties of erythrocytes.
    Toxicology mechanisms and methods, 2020, Volume: 30, Issue:4

    Topics: Amidohydrolases; Animals; Benzamides; Carbamates; Disease Models, Animal; Erythrocyte Membrane; Hypertension; Lipid Peroxidation; Male; N-Acetylneuraminic Acid; Oxidative Stress; Rats; Rats, Inbred SHR

2020
The endocannabinoid hydrolase FAAH is an allosteric enzyme.
    Scientific reports, 2020, 02-10, Volume: 10, Issue:1

    Topics: Allosteric Regulation; Allosteric Site; Amidohydrolases; Animals; Arachidonic Acids; Benzamides; Biocatalysis; Carbamates; Catalytic Domain; Drug Design; Endocannabinoids; Enzyme Assays; Humans; Hydrolysis; Kinetics; Molecular Dynamics Simulation; Mutation; Polyunsaturated Alkamides; Protein Subunits; Rats

2020
The effects of fatty acid amide hydrolase and monoacylglycerol lipase inhibitor treatments on lipopolysaccharide-induced airway inflammation in mice.
    Pulmonary pharmacology & therapeutics, 2020, Volume: 62

    Topics: Amidohydrolases; Animals; Arachidonic Acids; Benzamides; Benzodioxoles; Carbamates; Cytokines; Endocannabinoids; Glycerides; Inflammation; Lipopolysaccharides; Lung; Male; Mice; Monoacylglycerol Lipases; Piperidines; Pneumonia; Polyunsaturated Alkamides; Respiratory Hypersensitivity

2020
The fatty acid amide hydrolase inhibitor URB597 modulates splenic catecholamines in chronically stressed female and male rats.
    International immunopharmacology, 2020, Volume: 85

    Topics: Amidohydrolases; Animals; Anti-Anxiety Agents; Anxiety; Benzamides; Carbamates; Catechol O-Methyltransferase; Catecholamine Plasma Membrane Transport Proteins; Catecholamines; Endocannabinoids; Female; Interleukin-10; Interleukin-6; Male; Monoamine Oxidase; Neuroprotective Agents; Open Field Test; Phenylethanolamine N-Methyltransferase; Rats, Wistar; Sex Factors; Spleen; Stress, Physiological

2020
Visual High-Throughput Screening for Developing a Fatty Acid Amide Hydrolase Natural Inhibitor Based on an Enzyme-Activated Fluorescent Probe.
    Analytical chemistry, 2020, 07-21, Volume: 92, Issue:14

    Topics: Amidohydrolases; Benzamides; Carbamates; Cell Line; Cell Survival; Fluorescent Dyes; High-Throughput Screening Assays; Humans; Isoxazoles; Psoralea; Recombinant Proteins

2020
The FAAH Inhibitor URB597 Modulates Lipid Mediators in the Brain of Rats with Spontaneous Hypertension.
    Biomolecules, 2020, 07-10, Volume: 10, Issue:7

    Topics: Animals; Arachidonic Acids; Benzamides; Brain; Carbamates; Disease Models, Animal; Endocannabinoids; Hypertension; Injections, Intraperitoneal; Male; Malondialdehyde; Oxidation-Reduction; Phospholipids; Polyunsaturated Alkamides; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Receptor, Cannabinoid, CB2; Receptors, Cannabinoid; Receptors, G-Protein-Coupled

2020
Antidepressant-like effects of URB597 and JZL184 in male and female rats exposed to early life stress.
    European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology, 2020, Volume: 39

    Topics: Age Factors; Animals; Antidepressive Agents; Benzamides; Benzodioxoles; Carbamates; Depression; Female; Male; Piperidines; Rats; Rats, Sprague-Dawley; Social Interaction; Stress, Psychological; Treatment Outcome

2020
The fatty-acid amide hydrolase inhibitor URB597 inhibits MICA/B shedding.
    Scientific reports, 2020, 09-23, Volume: 10, Issue:1

    Topics: Amidohydrolases; Benzamides; Carbamates; Cell Line, Tumor; Culture Media; Gene Expression Regulation, Neoplastic; Histocompatibility Antigens Class I; Humans; Neoplasms; NK Cell Lectin-Like Receptor Subfamily K; T-Lymphocytes, Cytotoxic; Tissue Inhibitor of Metalloproteinase-3

2020
Effects of systemic endocannabinoid manipulation on social and exploratory behavior in prairie voles (Microtus ochrogaster).
    Psychopharmacology, 2021, Volume: 238, Issue:1

    Topics: Animals; Anxiety; Arachidonic Acids; Arvicolinae; Behavior, Animal; Benzamides; Carbamates; Endocannabinoids; Exploratory Behavior; Female; Male; Maze Learning; Nucleus Accumbens; Pair Bond; Polyunsaturated Alkamides; Pyrazoles; Receptor, Cannabinoid, CB1; Receptors, Oxytocin; Social Behavior

2021
Intravenous doxapram administration as a potential model of panic attacks in rats.
    Behavioural pharmacology, 2021, 04-01, Volume: 32, Issue:2&3

    Topics: Administration, Intravenous; Alprazolam; Animals; Benzamides; Carbamates; Central Nervous System Stimulants; Disease Models, Animal; Doxapram; Male; Maze Learning; Panic Disorder; Periaqueductal Gray; Proto-Oncogene Proteins c-fos; Rats; Rats, Wistar

2021
URB597 Prevents the Short-Term Excitotoxic Cell Damage in Rat Cortical Slices: Role of Cannabinoid 1 Receptors.
    Neurotoxicity research, 2021, Volume: 39, Issue:2

    Topics: Amidohydrolases; Animals; Apoptosis; Benzamides; Carbamates; Cells, Cultured; Cerebral Cortex; Male; Mitochondria; Neuroprotective Agents; Oxidative Stress; Quinolinic Acid; Rats, Wistar; Receptor, Cannabinoid, CB1

2021
URB597 abrogates anxiogenic and depressive behaviors in the methamphetamine-withdrawal mice: Role of the cannabinoid receptor type 1, cannabinoid receptor type 2, and transient receptor potential vanilloid 1 channels.
    Journal of psychopharmacology (Oxford, England), 2021, Volume: 35, Issue:7

    Topics: Amidohydrolases; Animals; Anxiety; Behavior, Animal; Benzamides; Cannabinoid Receptor Antagonists; Carbamates; Central Nervous System Stimulants; Depression; Disease Models, Animal; Endocannabinoids; Male; Methamphetamine; Mice; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Substance Withdrawal Syndrome; TRPV Cation Channels

2021
Anti-Inflammatory Effects of Fatty Acid Amide Hydrolase Inhibition in Monocytes/Macrophages from Alzheimer's Disease Patients.
    Biomolecules, 2021, 03-26, Volume: 11, Issue:4

    Topics: Aged; Alzheimer Disease; Amidohydrolases; Benzamides; Carbamates; Female; Humans; Interleukin-6; Leukocytes, Mononuclear; Lipopolysaccharides; Macrophages; Male; Middle Aged; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Tumor Necrosis Factor-alpha

2021
Beneficial Changes in Rat Vascular Endocannabinoid System in Primary Hypertension and under Treatment with Chronic Inhibition of Fatty Acid Amide Hydrolase by URB597.
    International journal of molecular sciences, 2021, May-02, Volume: 22, Issue:9

    Topics: Acetylcholine; Amidohydrolases; Animals; Aorta; Arachidonic Acids; Benzamides; Carbamates; Endocannabinoids; Essential Hypertension; Hypertension; Male; Mesenteric Arteries; Nitroprusside; Polyunsaturated Alkamides; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Receptors, Cannabinoid; Vasoconstriction; Vasodilation

2021
Neuroprotective Effects of VEGF-A Nanofiber Membrane and FAAH Inhibitor URB597 Against Oxygen-Glucose Deprivation-Induced Ischemic Neuronal Injury.
    International journal of nanomedicine, 2021, Volume: 16

    Topics: Amidohydrolases; Animals; Apoptosis; Benzamides; Brain Ischemia; Carbamates; Cells, Cultured; Endocannabinoids; Glucose; Hippocampus; Membranes, Artificial; Nanofibers; Neurons; Neuroprotective Agents; Oxygen; Rats, Sprague-Dawley; Vascular Endothelial Growth Factor A

2021
Kainate-Induced Degeneration of Hippocampal Neurons. Protective Effect of Activation of the Endocannabinoid System.
    Bulletin of experimental biology and medicine, 2021, Volume: 171, Issue:3

    Topics: Animals; Arachidonic Acids; Autophagosomes; Benzamides; CA3 Region, Hippocampal; Carbamates; Dentate Gyrus; Endocannabinoids; Endoplasmic Reticulum; Excitatory Amino Acid Agonists; Golgi Apparatus; Kainic Acid; Lysosomes; Male; Microscopy, Electron; Necrosis; Nerve Degeneration; Polyunsaturated Alkamides; Pyramidal Cells; Rats; Rats, Wistar; Status Epilepticus

2021
Fatty Acid Amide Hydrolase (FAAH) Inhibition Modulates Amyloid-Beta-Induced Microglia Polarization.
    International journal of molecular sciences, 2021, Jul-19, Volume: 22, Issue:14

    Topics: Alzheimer Disease; Amidohydrolases; Amyloid beta-Peptides; Animals; Arachidonic Acids; Benzamides; Carbamates; Cell Line; Cell Movement; Cell Polarity; Cytokines; Cytoskeleton; Disease Models, Animal; Endocannabinoids; Mice; Microglia; Polyunsaturated Alkamides

2021
The effect of URB597, exercise or their combination on the performance of 6-OHDA mouse model of Parkinson disease in the elevated plus maze, tail suspension test and step-down task.
    Metabolic brain disease, 2021, Volume: 36, Issue:8

    Topics: Animals; Behavior, Animal; Benzamides; Carbamates; Disease Models, Animal; Elevated Plus Maze Test; Hindlimb Suspension; Male; Mice; Mice, Inbred Strains; Oxidopamine; Parkinson Disease

2021
Effects of Fatty Acid Amide Hydroxylase Inhibitor URB597 on the Catecholaminergic Activity of the Adrenal Medulla in Stressed Male and Female Rats.
    Pharmacology, 2022, Volume: 107, Issue:1-2

    Topics: Adrenal Medulla; Amidohydrolases; Animals; Benzamides; Carbamates; Catechol O-Methyltransferase; Catecholamines; Endocannabinoids; Female; Male; Monoamine Oxidase; Organ Size; Pain; Rats, Wistar; Stress, Psychological

2022
Sex specific effects of the fatty acid amide hydrolase inhibitor URB597 on memory and brain β
    Neuroscience letters, 2022, 01-18, Volume: 768

    Topics: Amidohydrolases; Animals; Benzamides; Brain; Carbamates; Female; Male; Memory; Rats; Rats, Wistar; Receptors, Adrenergic, beta; Receptors, Dopamine D1; Sex Characteristics; Stress, Psychological

2022
Effect of Fatty Acid Amide Hydrolase Inhibitor URB597 on Orofacial Pain Perception in Rats.
    International journal of molecular sciences, 2022, Apr-23, Volume: 23, Issue:9

    Topics: Amidohydrolases; Animals; Benzamides; Calcitonin Gene-Related Peptide; Carbamates; Endocannabinoids; Facial Pain; Pain Perception; Polyunsaturated Alkamides; Rats; Receptor, Cannabinoid, CB1; Receptors, Cannabinoid; RNA, Messenger

2022
URB597 and Andrographolide Improve Brain Microvascular Endothelial Cell Permeability and Apoptosis by Reducing Oxidative Stress and Inflammation Associated with Activation of Nrf2 Signaling in Oxygen-Glucose Deprivation.
    Oxidative medicine and cellular longevity, 2022, Volume: 2022

    Topics: Anti-Inflammatory Agents; Apoptosis; Benzamides; Brain; Carbamates; Diterpenes; Endothelial Cells; Glucose; Humans; Inflammation; NF-E2-Related Factor 2; Oxidative Stress; Oxygen; Permeability; Reactive Oxygen Species

2022
Tonic Endocannabinoid Levels Modulate Retinal Signaling.
    International journal of environmental research and public health, 2022, 09-30, Volume: 19, Issue:19

    Topics: Animals; Benzamides; Cannabinoid Receptor Agonists; Carbamates; Endocannabinoids; Mice; Retina

2022