carbamates and saquinavir

carbamates has been researched along with saquinavir in 91 studies

Research

Studies (91)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	17 (18.68)	18.2507
2000's	60 (65.93)	29.6817
2010's	14 (15.38)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Anderson, B; Erickson, JW; Gulnik, SV; Liu, B; Mitsuya, H; Suvorov, LI; Yu, B	1
Alam, M; Bechtold, CM; Colonno, RJ; Gong, YF; Greytok, JA; Lin, PF; Robinson, BS; Rose, RE; Terry, BJ	1
Cullinan, AB; Livingston, DJ; Margolin, N; Pazhanisamy, S; Rao, BG; Stuver, CM	1
Blum, MR; Millard, J; Painter, G; Parry, N; Rooney, J; Sadler, BM; St Clair, MH; Tisdale, M	1
Blair, ED; Darby, G; Furfine, ES; Maschera, B; Myers, R; Palú, G; Tisdale, M; Wright, LL	1
Bold, G; Capraro, HG; Goutte, G; Klimkait, T; Lazdins, JK; Mestan, J; Walker, MR	1
Bridson, GW; Chaturvedi, PR; Decker, CJ; Laitinen, LM; Raybuck, SA; Tung, RD	1
Cammack, N; Chirn, GW; Craig, C; Dissanayeke, S; Duncan, IB; Gilbert, S; Moffatt, A; Race, E; Rose, J; Sheldon, J; Whittaker, L	1
Boden, D; Markowitz, M	1
Cassano, P; Clumeck, N; De Wit, S; Gerard, M; Hermans, P; Kabeya, K; O'Doherty, E	1
Temesgen, Z; Wright, AJ	1
Anderson, C; Craik, CS; Jolly, DJ; Todd, S	1
Heinrikson, RL; Tomasselli, AG	1
Bart, PA; Chapuis, A; De Boer, RJ; Fox, CH; Halkic, N; Hoover, S; Lange, JM; Lazzarin, A; Miller, V; Notermans, DW; Pantaleo, G; Perrin, L; Rizzardi, GP; Staszewski, S; Tambussi, G	1
Biollaz, J; Buclin, T; Decosterd, LA; Marzolini, C; Telenti, A	1
Daily, JP; Fahey, JM; Greenblatt, DJ; Perloff, MD; von Moltke, LL	1
Black, J; Markland, W; Parsons, JD; Rao, BG; Tisdale, M; Tung, R; Zuchowski, L	1
Jaillon, P; Poirier, JM; Radembino, N; Robidou, P	1
Condra, JH; Emini, EA; Petropoulos, CJ; Schleif, WA; Shivaprakash, M; Ziermann, R	1
Croom, DK; Furfine, ES; Lenhard, JM; Reynolds, DJ; Spaltenstein, A; Weiel, JE	1
Biryahwaho, B; Dondero, T; Downing, R; Hu, DJ; Lal, R; Mastro, T; Nkengasong, J; Pieniazek, D; Rayfield, M; Soriano, V; Tanuri, A; Wiktor, SZ	1
Blanchard, SG; Furfine, ES; Ittoop, O; Jain, RG; Lenhard, JM; Orband-Miller, LA; Paulik, MA; Weiel, JE	1
Korn, K; Moschik, B; Paatz, C; Schmidt, B; Uberla, K; Walter, H	1
Tavel, JA	1
Bart, PA; Chapuis, AG; Lazzarin, A; Pantaleo, G; Rizzardi, GP; Tambussi, G	1
Levin, J	1
Chang, HE	1
Coppedge, B	1
Fakuda, D	1
Iwamoto, A; Kotaki, H; Nakamura, T; Yamada, H	1
Blanco, JL; Carné, X; Gatell, JM; López-Púa, Y; Mallolas, J; Sarasa-Nacenta, M	1
Arrizabalaga, J; Clotet, B; Martínez-Picado, J; Ruiz, L	1
Bartoli, A; Feroggio, M; Gianelli, L; Maserati, R; Montagna, M; Regazzi, MB; Villani, P	1
Bourin, M; Dailly, E; Jolliet, P; Kergueris, MF; Thomas, L	1
Gantke, B; Kuschak, D; Mauss, S; Schmutz, G	1
Aubertin, AM; Gaucher, B; Greiner, J; Guedj, R; Rouquayrol, M; Vierling, P	1
Eron, JJ; Gillotin, C; Haubrich, R; Lang, W; Lou, Y; Sadler, BM; Stein, DS	1
Pereira, A; Taylor, S	1
Gao, W; Kishida, T; Okamoto, H; Shibata, N; Takada, K; Yoshikawa, Y	1
Jaillon, P; Poirier, JM; Robidou, P	2
Jain, RG; Lenhard, JM	1
Piliero, PJ	1
Edno-Mcheik, L; Lagrange, F; Molimard, M; Moore, N; Péhourcq, F; Titier, K	1
Aberg, JA; Bennett, KK; Bessen, LJ; Brosgart, C; DeGruttola, V; Eron, JJ; Gulick, RM; Hammer, SM; Holohan, MK; Karol, CN; Lewis, RH; Mellors, JW; Mitsuyasu, RT; Rogers, MD; Saah, AJ; Sheiner, L; Vaida, F; Valentine, FT; Wheat, LJ	1
Gao, W; Kageyama, M; Kimura, K; Kishida, T; Shibata, N; Takada, K; Yoshikawa, Y	1
Bennett, KK; Hammer, SM; Labbé, L; Lu, JF; Mellors, J; Pfister, M; Rosenkranz, S; Sheiner, LB	1
Aweeka, FT; Chi, J; Jayewardene, AL; Motoya, T; Stone, JA	1
Fukumoto, K; Fukushima, K; Gao, W; Inoue, Y; Kageyama, M; Nishimura, A; Shibata, N; Tadano, J; Takada, K; Yamasaki, D; Yoshikawa, Y	1
Hamm, G; Hube, B; Korting, HC; Krnjaic, N; Niewerth, M; Schaller, M	1
DiFrancesco, R; Frerichs, VA; Keil, K; Morse, G	1
Cammalleri, C; Colby-Germinario, SP; Germinario, RJ; Wainberg, MA	1
Ailhaud, G; Azoulay, S; Dani, C; Duval, D; Guedj, R; Vernochet, C	1
DeGoey, DA; Randolph, JT	1
Corbett, AH; Eron, JJ; Fiscus, SA; Kashuba, AD; Rezk, NL	1
Chappuy, H; Dimet, J; Firtion, G; Fouché, M; Mandelbrot, L; Pons, G; Rey, E; Tréluyer, JM	1
Back, D; Boffito, M; Dickinson, L; Fletcher, C; Gazzard, B; Higgs, C; Hill, A; Moyle, G; Nelson, M; Pozniak, A	1
Carter, HL; Danger, D; Furfine, ES; Hanlon, MH; Kaldor, IW; Miller, JF; Porter, DJ; Samano, VA; Shu, AY; Spaltenstein, A	1
Klein, HH; Meier, M; Schütt, M; Zhou, J	1
Arnedo, M; Biglia, MA; Blanco, JL; García, F; Gatell, JM; Laguno, M; Larrousse, M; Leon, A; Lonca, M; Mallolas, J; Martínez, E; Milinkovic, A; Miró, JM; Pumarola, T	1
Castagna, A; Cusato, M; Fusetti, G; Galli, A; Gianotti, N; Guffanti, M; Lazzarin, A; Regazzi, M; Seminari, E; Villani, P	1
Chai, H; Chen, C; Li, M; Lin, PH; Lumsden, AB; Yan, S; Yang, H; Yao, Q	1
Backman, JT; Granfors, MT; Kajosaari, LI; Laitila, J; Neuvonen, PJ; Wang, JS	1
Chang, CE; McCammon, JA; Shen, T; Tozzini, V; Trylska, J	1
Bacheler, L; Corral, A; de Mendoza, C; Pattery, T; Soriano, V; Valer, L	1
Chang, MS; El-Shourbagy, TA; Kim, EJ	1
de Hoon, J; Van Wijngaerden, E; Verbesselt, R	1
Balfour, HH; Brundage, RC; Vezina, HE; Weller, DR	1
Choi, SO; Kashuba, AD; Rezk, NL	1
Adams, E; Hoogmartens, J; Van Schepdael, A; Yekkala, R	1
Diaz, RS; Ferreira, PA; Tenore, S	1
Cheung, C; Gonzalez, FJ; Idle, JR; Krausz, KW; Ma, X; Shah, YM; Wang, T	1
Louis, JM; Sayer, JM	1
Boesmans, D; Di Fazio, V; Elens, L; Haufroid, V; Vanbinst, R; Veriter, S; Wallemacq, P	1
Annaert, P; Augustijns, P; Camus, S; Ye, ZW	1
Fessel, WJ; Hellinger, J; Kaufman, D; Rhee, SY; Ruane, P; Shafer, RW; Shirvani, V; Taylor, J; Towner, W; Troia, P; Zolopa, A	1
Harrison, RW; Kovalevsky, AY; Shen, CH; Wang, YF; Weber, IT	1
de Béthune, MP; De Meyer, S; Dierynck, I; Lathouwers, E; Picchio, G; Spinosa-Guzman, S; Van De Casteele, T; Vanden Abeele, C	1
Bogner, JR; Gyalrong-Steur, M; Seybold, U	1
Nsanzabana, C; Rosenthal, PJ	1
Appel, DI; Markowitz, JS; Peloquin, CA; Peterson, YK; Rhoades, JA; Zhu, HJ	1
Boross, PI; Chiu, TY; Ghosh, AK; Harrison, RW; Louis, JM; Tie, Y; Tozser, J; Wang, YF; Weber, IT	1
Baldi, A; Chirianni, A; De Luca, A; Esposito, V; Gargiulo, M; Lucariello, A; Manente, L; Parrella, G; Parrella, R; Perna, A; Viglietti, R	1
Leonis, G; Papadopoulos, MG; Steinbrecher, T	1
Bow, DA; Chiou, WJ; de Morais, SM; Kikuchi, R; Li, X; Voorman, RL	1
Amano, M; Das, D; Ghosh, AK; Mitsuya, H; Mizuno, A; Salcedo Gómez, PM; Yashchuk, S	1
Branquinha, MH; D Avila-Levy, CM; Menna-Barreto, RF; Sangenito, LS; Santos, AL	1
Cecka, F; Cerveny, L; Huliciak, M; Martinec, O; Staud, F; Vokral, I	1

Reviews

9 review(s) available for carbamates and saquinavir

Article	Year
Resistance to human immunodeficiency virus type 1 protease inhibitors. Antimicrobial agents and chemotherapy, 1998, Volume: 42, Issue:11 Topics: Carbamates; Drug Resistance; Furans; HIV Protease; HIV Protease Inhibitors; Indinavir; Nelfinavir; Pyridines; Pyrones; Ritonavir; Saquinavir; Structure-Activity Relationship; Sulfonamides	1998
Antiretrovirals. Mayo Clinic proceedings, 1999, Volume: 74, Issue:12 Topics: Adolescent; Adult; Alkynes; Anti-HIV Agents; Benzoxazines; Carbamates; Cyclopropanes; Delavirdine; Didanosine; Dideoxynucleosides; Female; Furans; HIV Infections; Humans; Indinavir; Lamivudine; Nelfinavir; Nevirapine; Oxazines; Pregnancy; Pregnancy Complications, Infectious; Protease Inhibitors; Reverse Transcriptase Inhibitors; Ritonavir; Saquinavir; Stavudine; Sulfonamides; Zalcitabine; Zidovudine	1999
HIV protease as a target for retrovirus vector-mediated gene therapy. Biochimica et biophysica acta, 2000, Mar-07, Volume: 1477, Issue:1-2 Topics: Amino Acid Sequence; Carbamates; Furans; Genetic Therapy; Genetic Vectors; HIV Protease; HIV Protease Inhibitors; HIV-1; Humans; Indinavir; Lentivirus; Models, Molecular; Molecular Structure; Nelfinavir; Retroviridae; Ritonavir; Saquinavir; Sulfonamides; Transfection	2000
Targeting the HIV-protease in AIDS therapy: a current clinical perspective. Biochimica et biophysica acta, 2000, Mar-07, Volume: 1477, Issue:1-2 Topics: Acquired Immunodeficiency Syndrome; Anti-HIV Agents; Binding Sites; Carbamates; Clinical Trials as Topic; Computer-Aided Design; Crystallography, X-Ray; Drug Design; Drug Resistance, Microbial; Drug Therapy, Combination; Furans; HIV Protease; HIV Protease Inhibitors; HIV-1; Humans; Indinavir; Nelfinavir; Oligopeptides; Pyridines; Pyrones; Randomized Controlled Trials as Topic; Ritonavir; Saquinavir; Sulfonamides	2000
Ongoing trials in HIV protease inhibitors. Expert opinion on investigational drugs, 2000, Volume: 9, Issue:4 Topics: Carbamates; Clinical Trials as Topic; Furans; HIV Infections; HIV Protease Inhibitors; Humans; Indinavir; Nelfinavir; Ritonavir; Saquinavir; Sulfonamides; United States; United States Food and Drug Administration	2000
[Resistance to protease inhibitors]. Enfermedades infecciosas y microbiologia clinica, 2001, Volume: 19, Issue:Monografic Topics: Carbamates; Drug Resistance, Microbial; Furans; HIV; HIV Infections; HIV Protease; HIV Protease Inhibitors; Humans; Indinavir; Mutation; Nelfinavir; Ritonavir; Saquinavir; Sulfonamides	2001
Penetration of HIV-1 protease inhibitors into CSF and semen. HIV medicine, 2000, Volume: 1 Suppl 2 Topics: Carbamates; CD4 Lymphocyte Count; Female; Furans; HIV Infections; HIV Protease Inhibitors; HIV-1; Humans; Male; Nelfinavir; Ritonavir; Saquinavir; Semen; Sulfonamides; Viral Load	2000
Peptidomimetic inhibitors of HIV protease. Current topics in medicinal chemistry, 2004, Volume: 4, Issue:10 Topics: Anti-HIV Agents; Atazanavir Sulfate; Carbamates; Clinical Trials as Topic; Dipeptides; Furans; HIV; HIV Infections; HIV Protease Inhibitors; Humans; Indinavir; Lopinavir; Models, Molecular; Molecular Mimicry; Molecular Structure; Nelfinavir; Oligopeptides; Organophosphates; Peptides; Phenylbutyrates; Pyridines; Pyrimidinones; Ritonavir; Saquinavir; Sulfonamides; Urethane	2004
Quality control of protease inhibitors. Journal of pharmaceutical sciences, 2008, Volume: 97, Issue:6 Topics: Anti-HIV Agents; Atazanavir Sulfate; Carbamates; Chromatography, Liquid; Darunavir; Drug Contamination; Furans; HIV Protease Inhibitors; Indinavir; Lopinavir; Nelfinavir; Oligopeptides; Organophosphates; Pyridines; Pyrimidinones; Pyrones; Quality Control; Ritonavir; Saquinavir; Sulfonamides	2008

Trials

9 trial(s) available for carbamates and saquinavir

Article	Year
In vitro antiviral activity of 141W94 (VX-478) in combination with other antiretroviral agents. Antiviral research, 1996, Volume: 29, Issue:1 Topics: Carbamates; Drug Resistance, Microbial; Drug Synergism; Drug Therapy, Combination; Furans; HIV Infections; HIV Protease Inhibitors; Humans; Indinavir; Isoquinolines; Pyridines; Quinolines; Reverse Transcriptase Inhibitors; Ritonavir; Saquinavir; Sulfonamides; Thiazoles; Valine	1996
Drug resistance and predicted virologic responses to human immunodeficiency virus type 1 protease inhibitor therapy. The Journal of infectious diseases, 2000, Volume: 182, Issue:3 Topics: Carbamates; Drug Resistance, Microbial; Drug Synergism; Drug Therapy, Combination; Furans; Genotype; HIV Infections; HIV Protease Inhibitors; HIV-1; Humans; Indinavir; Nelfinavir; Phenotype; Protein Binding; Ritonavir; Saquinavir; Sulfonamides	2000
Virological and immunological responses to HAART in asymptomatic therapy-naive HIV-1-infected subjects according to CD4 cell count. AIDS (London, England), 2000, Oct-20, Volume: 14, Issue:15 Topics: Adult; Anti-HIV Agents; Antigens, Fungal; Antigens, Viral; Antiretroviral Therapy, Highly Active; Candida albicans; Carbamates; CD4 Lymphocyte Count; Chronic Disease; Cytomegalovirus; Dideoxynucleosides; Drug Therapy, Combination; Furans; HIV Infections; HIV Protease Inhibitors; HIV-1; Humans; Nelfinavir; Prospective Studies; Reverse Transcriptase Inhibitors; RNA, Viral; Saquinavir; Simplexvirus; Sulfonamides; T-Lymphocyte Subsets	2000
Pharmacokinetic study of human immunodeficiency virus protease inhibitors used in combination with amprenavir. Antimicrobial agents and chemotherapy, 2001, Volume: 45, Issue:12 Topics: Adult; Area Under Curve; Carbamates; CD4 Lymphocyte Count; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Drug Interactions; Enzyme Inhibitors; Female; Furans; HIV Protease Inhibitors; HIV Seropositivity; Humans; Indinavir; Male; Mixed Function Oxygenases; Nelfinavir; Orosomucoid; Saquinavir; Sulfonamides	2001
Dual vs single protease inhibitor therapy following antiretroviral treatment failure: a randomized trial. JAMA, 2002, Jul-10, Volume: 288, Issue:2 Topics: Adenine; Adult; Alkynes; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Benzoxazines; Carbamates; CD4 Lymphocyte Count; Cyclopropanes; Dideoxynucleosides; Disease Progression; Double-Blind Method; Drug Resistance, Viral; Female; Furans; HIV Infections; HIV Protease Inhibitors; Humans; Indinavir; Male; Nelfinavir; Organophosphonates; Oxazines; Proportional Hazards Models; Reverse Transcriptase Inhibitors; Saquinavir; Sulfonamides; Treatment Failure; Viral Load	2002
Effect of coadministration of nelfinavir, indinavir, and saquinavir on the pharmacokinetics of amprenavir. Clinical pharmacology and therapeutics, 2002, Volume: 72, Issue:2 Topics: Adult; Biological Availability; Carbamates; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Drug Administration Schedule; Drug Therapy, Combination; Female; Furans; HIV Protease Inhibitors; Humans; Indinavir; Male; Middle Aged; Mixed Function Oxygenases; Nelfinavir; Saquinavir; Sulfonamides	2002
The pharmacokinetics, safety, and initial virologic response of a triple-protease inhibitor salvage regimen containing amprenavir, saquinavir, and ritonavir. Journal of acquired immune deficiency syndromes (1999), 2004, Aug-01, Volume: 36, Issue:4 Topics: Adult; Carbamates; CD4 Lymphocyte Count; Drug Administration Schedule; Drug Therapy, Combination; Female; Furans; HIV Infections; HIV Protease Inhibitors; HIV-1; Humans; Male; Middle Aged; Ritonavir; Salvage Therapy; Saquinavir; Sulfonamides; Viral Load	2004
Saquinavir plus lopinavir/ritonavir versus amprenavir plus lopinavir/ritonavir for treating highly resistant patients in Brazil. Journal of acquired immune deficiency syndromes (1999), 2008, Apr-01, Volume: 47, Issue:4 Topics: Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Brazil; Carbamates; CD4 Lymphocyte Count; Drug Resistance, Viral; Drug Therapy, Combination; Female; Furans; HIV Infections; HIV Protease Inhibitors; Humans; Lopinavir; Male; Pilot Projects; Prospective Studies; Pyrimidinones; Ritonavir; Saquinavir; Sulfonamides; Treatment Outcome	2008
In vitro susceptibility and virological outcome to darunavir and lopinavir are independent of HIV type-1 subtype in treatment-naive patients. Antiviral therapy, 2010, Volume: 15, Issue:8 Topics: Adamantane; Adult; Analysis of Variance; Atazanavir Sulfate; Carbamates; Darunavir; Drug Resistance, Viral; Furans; HIV Infections; HIV Protease Inhibitors; HIV-1; Humans; Indinavir; Lopinavir; Microbial Sensitivity Tests; Molecular Typing; Nelfinavir; Neuraminidase; Oligopeptides; Pyridines; Pyrimidinones; Pyrones; Saquinavir; Sulfonamides; Viral Load	2010

Other Studies

73 other study(ies) available for carbamates and saquinavir

Article	Year
Kinetic characterization and cross-resistance patterns of HIV-1 protease mutants selected under drug pressure. Biochemistry, 1995, Jul-25, Volume: 34, Issue:29 Topics: Amino Acid Sequence; Binding Sites; Carbamates; Cloning, Molecular; Drug Resistance, Microbial; HIV Protease; HIV Protease Inhibitors; HIV-1; Indinavir; Isoquinolines; Kinetics; Methylurea Compounds; Mutagenesis, Site-Directed; Oligopeptides; Point Mutation; Pyridines; Quinolines; Recombinant Proteins; Saquinavir; Structure-Activity Relationship; Thiazoles; Valine	1995
Human immunodeficiency virus type 1 viral background plays a major role in development of resistance to protease inhibitors. Proceedings of the National Academy of Sciences of the United States of America, 1996, Feb-20, Volume: 93, Issue:4 Topics: Amino Acid Sequence; Carbamates; Clone Cells; DNA Mutational Analysis; DNA, Recombinant; DNA, Viral; Drug Administration Schedule; Drug Resistance, Microbial; Drug Therapy, Combination; Ethanolamines; HeLa Cells; HIV Protease; HIV Protease Inhibitors; HIV-1; Humans; Indinavir; Isoquinolines; Methylurea Compounds; Molecular Sequence Data; Point Mutation; Proviruses; Pyridines; Quinolines; Reassortant Viruses; Recombinant Fusion Proteins; Saquinavir; T-Lymphocytes; Urea; Valine	1996
Kinetic characterization of human immunodeficiency virus type-1 protease-resistant variants. The Journal of biological chemistry, 1996, Jul-26, Volume: 271, Issue:30 Topics: Amino Acid Sequence; Binding Sites; Carbamates; Furans; Genetic Variation; HIV Protease; HIV Protease Inhibitors; HIV-1; Hydrolysis; Indinavir; Isoquinolines; Kinetics; Models, Molecular; Molecular Sequence Data; Mutation; Oligopeptides; Pyridines; Quinolines; Saquinavir; Selection, Genetic; Substrate Specificity; Sulfonamides	1996
Human immunodeficiency virus. Mutations in the viral protease that confer resistance to saquinavir increase the dissociation rate constant of the protease-saquinavir complex. The Journal of biological chemistry, 1996, Dec-27, Volume: 271, Issue:52 Topics: Antiviral Agents; Carbamates; Drug Resistance, Microbial; Furans; HIV Protease; HIV Protease Inhibitors; Humans; Indinavir; Isoquinolines; Kinetics; Mutagenesis; Nelfinavir; Ritonavir; Saquinavir; Sulfonamides; Sulfonic Acids	1996
In vitro effect of alpha1-acid glycoprotein on the anti-human immunodeficiency virus (HIV) activity of the protease inhibitor CGP 61755: a comparative study with other relevant HIV protease inhibitors. The Journal of infectious diseases, 1997, Volume: 175, Issue:5 Topics: Anti-HIV Agents; Carbamates; Cell Line; Cells, Cultured; Ethylenes; Furans; HIV Protease Inhibitors; HIV Seronegativity; HIV-1; Humans; Indinavir; Kinetics; Lymphocytes; Orosomucoid; Ritonavir; Saquinavir; Sulfonamides; Urea; Virus Replication	1997
Metabolism of amprenavir in liver microsomes: role of CYP3A4 inhibition for drug interactions. Journal of pharmaceutical sciences, 1998, Volume: 87, Issue:7 Topics: Anti-HIV Agents; Carbamates; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Drug Interactions; Enzyme Inhibitors; Furans; HIV Protease Inhibitors; Humans; Isoenzymes; Microsomes, Liver; Mixed Function Oxygenases; Ritonavir; Saquinavir; Sulfonamides	1998
HIV protease genotype and viral sensitivity to HIV protease inhibitors following saquinavir therapy. AIDS (London, England), 1998, Sep-10, Volume: 12, Issue:13 Topics: Amino Acid Substitution; Carbamates; Clinical Trials as Topic; Databases, Factual; DNA, Viral; Furans; Genetic Linkage; Genotype; HIV Infections; HIV Protease; HIV Protease Inhibitors; Humans; Indinavir; Methionine; Nelfinavir; Phenotype; Polymerase Chain Reaction; Ritonavir; Saquinavir; Sulfonamides; Valine	1998
Salvage therapy with ritonavir-saquinavir plus two nucleoside reverse transcriptase inhibitors in patients failing with amprenavir-zidovudine-lamivudine. AIDS (London, England), 1999, May-07, Volume: 13, Issue:7 Topics: Adult; Anti-HIV Agents; Carbamates; Drug Therapy, Combination; Furans; HIV Infections; HIV Protease Inhibitors; Humans; Lamivudine; Male; Middle Aged; Reverse Transcriptase Inhibitors; Ritonavir; Salvage Therapy; Saquinavir; Sulfonamides; Zidovudine	1999
Predicting the duration of antiviral treatment needed to suppress plasma HIV-1 RNA. The Journal of clinical investigation, 2000, Volume: 105, Issue:6 Topics: Adult; Anti-HIV Agents; Carbamates; CD4 Lymphocyte Count; CD4-Positive T-Lymphocytes; Cohort Studies; Dideoxynucleosides; Furans; HIV Infections; HIV Protease Inhibitors; HIV Reverse Transcriptase; HIV-1; Humans; Lamivudine; Lymph Nodes; Nelfinavir; Reverse Transcriptase Inhibitors; RNA, Viral; Saquinavir; Stavudine; Sulfonamides; Time Factors; Viral Load; Viremia; Zidovudine	2000
Simultaneous determination of the HIV protease inhibitors indinavir, amprenavir, saquinavir, ritonavir, nelfinavir and the non-nucleoside reverse transcriptase inhibitor efavirenz by high-performance liquid chromatography after solid-phase extraction. Journal of chromatography. B, Biomedical sciences and applications, 2000, Mar-31, Volume: 740, Issue:1 Topics: Alkynes; Benzoxazines; Calibration; Carbamates; Chromatography, High Pressure Liquid; Cyclopropanes; Drug Stability; Furans; HIV Infections; HIV Protease Inhibitors; Humans; Indinavir; Nelfinavir; Oxazines; Reproducibility of Results; Reverse Transcriptase Inhibitors; Ritonavir; Saquinavir; Sulfonamides	2000
Induction of P-glycoprotein expression by HIV protease inhibitors in cell culture. AIDS (London, England), 2000, Jun-16, Volume: 14, Issue:9 Topics: Adenocarcinoma; ATP Binding Cassette Transporter, Subfamily B, Member 1; Carbamates; Cell Line, Transformed; Colonic Neoplasms; Drug Resistance, Multiple; Furans; Gene Expression Regulation, Neoplastic; HIV Protease Inhibitors; Humans; Indinavir; Ivermectin; Nelfinavir; Ritonavir; Saquinavir; Sulfonamides; Tumor Cells, Cultured; Verapamil; Vinblastine	2000
Structural and kinetic analyses of the protease from an amprenavir-resistant human immunodeficiency virus type 1 mutant rendered resistant to saquinavir and resensitized to amprenavir. Journal of virology, 2000, Volume: 74, Issue:16 Topics: Carbamates; Crystallography, X-Ray; Drug Resistance, Microbial; Furans; HIV Protease; HIV Protease Inhibitors; HIV-1; Humans; Kinetics; Models, Molecular; Mutation; Protein Conformation; Saquinavir; Sulfonamides	2000
Simultaneous determination of the five HIV-protease inhibitors: amprenavir, indinavir, nelfinavir, ritonavir, and saquinavir in human plasma by solid-phase extraction and column liquid chromatography. Therapeutic drug monitoring, 2000, Volume: 22, Issue:4 Topics: Carbamates; Chromatography, Liquid; Drug Monitoring; Furans; HIV Protease Inhibitors; Humans; Nelfinavir; Ritonavir; Saquinavir; Sulfonamides	2000
Dietary fat alters HIV protease inhibitor-induced metabolic changes in mice. The Journal of nutrition, 2000, Volume: 130, Issue:9 Topics: Adipose Tissue; Animals; Blood Glucose; Body Weight; Carbamates; Dietary Fats; Drug Interactions; Furans; HIV Protease Inhibitors; Indinavir; Injections, Subcutaneous; Insulin; Liver; Male; Mice; Mice, Inbred AKR; Nelfinavir; Saquinavir; Sulfonamides	2000
Protease sequences from HIV-1 group M subtypes A-H reveal distinct amino acid mutation patterns associated with protease resistance in protease inhibitor-naive individuals worldwide. HIV Variant Working Group. AIDS (London, England), 2000, Jul-28, Volume: 14, Issue:11 Topics: Amino Acid Sequence; Amino Acid Substitution; Carbamates; Codon; Drug Resistance, Microbial; Furans; Global Health; HIV Protease; HIV Protease Inhibitors; HIV-1; Humans; Indinavir; Molecular Sequence Data; Mutation; Nelfinavir; Phylogeny; Ritonavir; Saquinavir; Sulfonamides	2000
HIV protease inhibitors block adipogenesis and increase lipolysis in vitro. Antiviral research, 2000, Volume: 47, Issue:2 Topics: Adipocytes; Animals; Azo Compounds; Bexarotene; Carbamates; Carrier Proteins; Cell Differentiation; Cells, Cultured; Coloring Agents; Fatty Acid-Binding Proteins; Furans; HIV Protease Inhibitors; Indinavir; Insulin; Lipolysis; Lipoprotein Lipase; Nelfinavir; Neoplasm Proteins; Receptors, Cytoplasmic and Nuclear; Receptors, Retinoic Acid; Retinoid X Receptors; Ritonavir; RNA, Messenger; Rosiglitazone; Saquinavir; Stem Cells; Sulfonamides; Tetrahydronaphthalenes; Thiazoles; Thiazolidinediones; Transcription Factors; Triglycerides	2000
Low level of cross-resistance to amprenavir (141W94) in samples from patients pretreated with other protease inhibitors. Antimicrobial agents and chemotherapy, 2000, Volume: 44, Issue:11 Topics: Carbamates; Drug Resistance, Microbial; Drug Resistance, Multiple; Furans; HIV Infections; HIV Protease Inhibitors; HIV-1; Humans; Indinavir; Ritonavir; Saquinavir; Sulfonamides	2000
Abacavir (1592) with protease inhibitors in potent antiretroviral activity. AIDS patient care and STDs, 1998, Volume: 12, Issue:4 Topics: Acquired Immunodeficiency Syndrome; Anti-HIV Agents; Carbamates; Dideoxynucleosides; Drug Therapy, Combination; Furans; HIV Protease Inhibitors; Humans; Indinavir; Nelfinavir; Ritonavir; Saquinavir; Sulfonamides; Viral Load	1998
Double protease inhibitor regimens with amprenavir show promise. AIDS patient care and STDs, 1998, Volume: 12, Issue:4 Topics: Anti-HIV Agents; Carbamates; Drug Therapy, Combination; Furans; HIV Infections; HIV Protease Inhibitors; Humans; Indinavir; Lamivudine; Saquinavir; Sulfonamides; Viral Load; Zidovudine	1998
Protease inhibitors and prevention of cross resistance. AIDS treatment news, 1995, Oct-06, Issue:no 232 Topics: Acquired Immunodeficiency Syndrome; Antiviral Agents; Carbamates; Didanosine; Drug Resistance, Microbial; Drug Therapy, Combination; Furans; HIV Infections; HIV Protease Inhibitors; HIV-1; Humans; Indinavir; Isoquinolines; Lamivudine; Nelfinavir; Pyridines; Quinolines; Saquinavir; Sulfonamides; Zalcitabine; Zidovudine	1995
Conference looks at HIV drug resistance. GMHC treatment issues : the Gay Men's Health Crisis newsletter of experimental AIDS therapies, 1995, Volume: 9, Issue:9 Topics: Antiviral Agents; Carbamates; CD4 Lymphocyte Count; Drug Resistance, Microbial; Furans; HIV; HIV Infections; HIV Protease Inhibitors; Humans; Indinavir; Isoquinolines; Lamivudine; Pyridines; Quinolines; Ritonavir; Saquinavir; Sulfonamides; Thiazoles; Valine; Viremia; Zalcitabine; Zidovudine	1995
ICAAC update. STEP perspective, 1996,Fall, Volume: 8, Issue:3 Topics: Acetamides; Acetophenones; Anti-HIV Agents; Carbamates; CD4 Lymphocyte Count; Clinical Trials as Topic; Disease Progression; Drug Therapy, Combination; Drugs, Investigational; Furans; HIV Infections; HIV Protease Inhibitors; Humans; Lamivudine; Reverse Transcriptase Inhibitors; Ritonavir; Saquinavir; Sulfonamides; Viral Load	1996
What's new, what's next? Positive Directions news : a support and information network of people with HIV/AIDS, their families, friends and providers, 1998,Summer, Volume: 10, Issue:2 Topics: Adenine; Anti-HIV Agents; Antiviral Agents; Carbamates; Decision Making; Dideoxynucleosides; Drug Resistance, Microbial; Drug Therapy, Combination; Furans; HIV Infections; HIV Protease Inhibitors; Humans; Hydroxyurea; Patient Compliance; Saquinavir; Sulfonamides	1998
Simultaneous determination of the HIV protease inhibitors indinavir, amprenavir, saquinavir, ritonavir and nelfinavir in human plasma by high-performance liquid chromatography. Journal of chromatography. B, Biomedical sciences and applications, 2001, May-05, Volume: 755, Issue:1-2 Topics: Adult; Calibration; Carbamates; Chromatography, High Pressure Liquid; Furans; HIV Protease Inhibitors; Humans; Indinavir; Male; Nelfinavir; Ritonavir; Saquinavir; Sulfonamides	2001
Simultaneous determination of the HIV-protease inhibitors indinavir, amprenavir, ritonavir, saquinavir and nelfinavir in human plasma by reversed-phase high-performance liquid chromatography. Journal of chromatography. B, Biomedical sciences and applications, 2001, Jun-15, Volume: 757, Issue:2 Topics: Carbamates; Chromatography, High Pressure Liquid; Furans; HIV Infections; HIV Protease Inhibitors; Humans; Indinavir; Nelfinavir; Reference Standards; Reproducibility of Results; Ritonavir; Saquinavir; Sensitivity and Specificity; Spectrophotometry, Ultraviolet; Sulfonamides	2001
Antiretrovirals: simultaneous determination of five protease inhibitors and three nonnucleoside transcriptase inhibitors in human plasma by a rapid high-performance liquid chromatography--mass spectrometry assay. Therapeutic drug monitoring, 2001, Volume: 23, Issue:4 Topics: Alkynes; Benzoxazines; Carbamates; Chromatography, Liquid; Cyclopropanes; Delavirdine; Drug Monitoring; Furans; HIV Protease Inhibitors; Humans; Indinavir; Mass Spectrometry; Nelfinavir; Nevirapine; Oxazines; Reproducibility of Results; Reverse Transcriptase Inhibitors; Ritonavir; Saquinavir; Sensitivity and Specificity; Sulfonamides	2001
High-performance liquid chromatographic assay to determine the plasma levels of HIV-protease inhibitors (amprenavir, indinavir, nelfinavir, ritonavir and saquinavir) and the non-nucleoside reverse transcriptase inhibitor (nevirapine) after liquid-liquid e Journal of chromatography. B, Biomedical sciences and applications, 2001, Jul-15, Volume: 758, Issue:2 Topics: Calibration; Carbamates; Chromatography, High Pressure Liquid; Furans; HIV Protease Inhibitors; Humans; Indinavir; Nelfinavir; Nevirapine; Reference Standards; Reproducibility of Results; Reverse Transcriptase Inhibitors; Ritonavir; Saquinavir; Sensitivity and Specificity; Sulfonamides	2001
Simultaneous determination of the new HIV protease inhibitor lopinavir (ABT 378) and of indinavir(1), amprenavir, saquinavir, ritonavir (ABT 538)(2) and nelfinavir(3) in human plasma by gradient HPLC. Clinical laboratory, 2001, Volume: 47, Issue:9-10 Topics: Carbamates; Chromatography, High Pressure Liquid; Drug Interactions; Drug Monitoring; Drug Therapy, Combination; Furans; HIV Protease Inhibitors; Humans; Indinavir; Lopinavir; Nelfinavir; Pyrimidinones; Reproducibility of Results; Ritonavir; Saquinavir; Sulfonamides	2001
Synthesis and anti-HIV activity of glucose-containing prodrugs derived from saquinavir, indinavir and nelfinavir. Carbohydrate research, 2001, Nov-21, Volume: 336, Issue:3 Topics: Carbamates; Cell Survival; Cross-Linking Reagents; Esters; Glucose; Half-Life; HIV Protease Inhibitors; HIV-1; Humans; Hydrolysis; Indinavir; Nelfinavir; Prodrugs; Saquinavir; Tumor Cells, Cultured	2001
In-vitro and in-vivo pharmacokinetic interactions of amprenavir, an HIV protease inhibitor, with other current HIV protease inhibitors in rats. The Journal of pharmacy and pharmacology, 2002, Volume: 54, Issue:2 Topics: Administration, Oral; Animals; Area Under Curve; Biological Availability; Carbamates; Chromatography, High Pressure Liquid; Drug Interactions; Furans; HIV Protease Inhibitors; In Vitro Techniques; Indinavir; Male; Microsomes, Liver; Nelfinavir; Rats; Rats, Wistar; Saquinavir; Sulfonamides; Time Factors	2002
Simultaneous determination of the six HIV protease inhibitors (amprenavir, indinavir, lopinavir, nelfinavir, ritonavir, and saquinavir) plus M8 nelfinavir metabolite and the nonnucleoside reverse transcription inhibitor efavirenz in human plasma by solid- Therapeutic drug monitoring, 2002, Volume: 24, Issue:2 Topics: Alkynes; Benzoxazines; Carbamates; Chromatography, Liquid; Cyclopropanes; Drug Monitoring; Furans; HIV Protease Inhibitors; Humans; Indinavir; Lopinavir; Nelfinavir; Oxazines; Pyrimidinones; Reproducibility of Results; Reverse Transcriptase Inhibitors; Ritonavir; Saquinavir; Sulfonamides	2002
Select HIV protease inhibitors alter bone and fat metabolism ex vivo. The Journal of biological chemistry, 2002, May-31, Volume: 277, Issue:22 Topics: Adipocytes; Animals; Animals, Newborn; Bone and Bones; Calcium; Carbamates; Cells, Cultured; Down-Regulation; Fats; Furans; Glycoproteins; HIV Protease Inhibitors; Humans; Indinavir; Lopinavir; Mesoderm; Nelfinavir; Osteoblasts; Osteoclasts; Osteoprotegerin; Pyrimidinones; Rats; Rats, Wistar; Receptors, Cytoplasmic and Nuclear; Receptors, Tumor Necrosis Factor; Ritonavir; Saquinavir; Skull; Stem Cells; Sulfonamides	2002
The utility of inhibitory quotients in determining the relative potency of protease inhibitors. AIDS (London, England), 2002, Mar-29, Volume: 16, Issue:5 Topics: Carbamates; Drug Evaluation; Furans; HIV Protease Inhibitors; Humans; Indinavir; Nelfinavir; Ritonavir; Saquinavir; Sulfonamides	2002
High-performance liquid chromatographic method for the simultaneous determination of the six HIV-protease inhibitors and two non-nucleoside reverse transcriptase inhibitors in human plasma. Therapeutic drug monitoring, 2002, Volume: 24, Issue:3 Topics: Alkynes; Benzoxazines; Carbamates; Chromatography, High Pressure Liquid; Cyclopropanes; Drug Monitoring; Furans; HIV Infections; Humans; Indinavir; Lopinavir; Nelfinavir; Nevirapine; Oxazines; Protease Inhibitors; Pyrimidinones; Reproducibility of Results; Reverse Transcriptase Inhibitors; Ritonavir; Saquinavir; Sulfonamides	2002
Hepatic and intestinal contributions to pharmacokinetic interaction of indinavir with amprenavir, nelfinavir and saquinavir in rats. Antiviral chemistry & chemotherapy, 2002, Volume: 13, Issue:1 Topics: Animals; Area Under Curve; Carbamates; Drug Interactions; Drug Therapy, Combination; Furans; Half-Life; HIV Protease Inhibitors; Indinavir; Intestinal Mucosa; Liver; Male; Microsomes, Liver; Nelfinavir; Rats; Rats, Wistar; Saquinavir; Sulfonamides	2002
Simultaneous determination of five HIV protease inhibitors nelfinavir, indinavir, ritonavir, saquinavir and amprenavir in human plasma by LC/MS/MS. Journal of pharmaceutical and biomedical analysis, 2002, Oct-15, Volume: 30, Issue:3 Topics: Carbamates; Chromatography, Liquid; Furans; Gas Chromatography-Mass Spectrometry; HIV Protease Inhibitors; Indinavir; Nelfinavir; Ritonavir; Saquinavir; Sulfonamides	2002
Effect of indinavir on the intestinal exsorption of amprenavir, saquinavir and nelfinavir after intravenous administration in rats. Biological & pharmaceutical bulletin, 2003, Volume: 26, Issue:2 Topics: Animals; Carbamates; Drug Interactions; Furans; Indinavir; Infusions, Intravenous; Intestinal Absorption; Male; Microsomes, Liver; Nelfinavir; Rats; Rats, Wistar; Saquinavir; Sulfonamides	2003
Effect of antimycotic agents on the activity of aspartyl proteinases secreted by Candida albicans. Journal of medical microbiology, 2003, Volume: 52, Issue:Pt 3 Topics: Antifungal Agents; Aspartic Acid Endopeptidases; Candida albicans; Carbamates; Cell Adhesion; Dose-Response Relationship, Drug; Furans; HIV Protease Inhibitors; Saquinavir; Sulfonamides	2003
Reverse phase high-performance liquid chromatography method for the analysis of amprenavir, efavirenz, indinavir, lopinavir, nelfinavir and its active metabolite (M8), ritonavir, and saquinavir in heparinized human plasma. Therapeutic drug monitoring, 2003, Volume: 25, Issue:3 Topics: Alkynes; Anti-HIV Agents; Benzoxazines; Carbamates; Chromatography, High Pressure Liquid; Cyclopropanes; Furans; Heparin; HIV Protease Inhibitors; Humans; Indinavir; Lopinavir; Nelfinavir; Oxazines; Pyrimidinones; Ritonavir; Saquinavir; Sulfonamides	2003
The long-term effects of anti-retroviral protease inhibitors on sugar transport in L6 cells. The Journal of endocrinology, 2003, Volume: 178, Issue:3 Topics: Biological Transport; Blotting, Western; Carbamates; Cell Membrane; Cells, Cultured; Deoxyglucose; Furans; Glucose Transporter Type 1; Glucose Transporter Type 3; Glucose Transporter Type 4; HIV Protease Inhibitors; Humans; Indinavir; Insulin; Monosaccharide Transport Proteins; Muscle Proteins; Myoblasts; Nerve Tissue Proteins; Ritonavir; Saquinavir; Sulfonamides	2003
Differential effect of HIV protease inhibitors on adipogenesis: intracellular ritonavir is not sufficient to inhibit differentiation. AIDS (London, England), 2003, Oct-17, Volume: 17, Issue:15 Topics: 3T3 Cells; Adipocytes; Animals; Carbamates; Cell Differentiation; Cell Line; Enzyme-Linked Immunosorbent Assay; Furans; HIV Protease Inhibitors; Indinavir; Lopinavir; Mice; Mice, Inbred Strains; Nelfinavir; Pyrimidinones; Ritonavir; Saquinavir; Sulfonamides	2003
Maternal-fetal transfer and amniotic fluid accumulation of protease inhibitors in pregnant women who are infected with human immunodeficiency virus. American journal of obstetrics and gynecology, 2004, Volume: 191, Issue:2 Topics: Adult; Amniotic Fluid; Carbamates; Drug Therapy, Combination; Female; Furans; HIV Infections; HIV Protease Inhibitors; Humans; Indinavir; Maternal-Fetal Exchange; Nelfinavir; Pregnancy; Pregnancy Complications, Infectious; Ritonavir; Saquinavir; Sulfonamides	2004
[FPV plus SQV plus a mini-dose ritonavir. "Double boosting with compatible partners]. MMW Fortschritte der Medizin, 2004, Apr-26, Volume: 146 Spec No 1 Topics: Anti-HIV Agents; Carbamates; Clinical Trials as Topic; Cross-Over Studies; Drug Administration Schedule; Drug Synergism; Drug Therapy, Combination; Furans; HIV Infections; HIV Protease Inhibitors; Humans; Organophosphates; Prodrugs; Ritonavir; Saquinavir; Sulfonamides	2004
Steady-State pharmacokinetics of saquinavir hard-gel/ritonavir/fosamprenavir in HIV-1-infected patients. Journal of acquired immune deficiency syndromes (1999), 2004, Nov-01, Volume: 37, Issue:3 Topics: Acquired Immunodeficiency Syndrome; Adult; Aged; Area Under Curve; Carbamates; Drug Administration Schedule; Drug Therapy, Combination; Furans; HIV Infections; HIV Protease Inhibitors; HIV-1; Humans; Metabolic Clearance Rate; Middle Aged; Organophosphates; Ritonavir; RNA, Viral; Saquinavir; Sulfonamides; Viral Load	2004
Inhibition of wild-type and mutant human immunodeficiency virus type 1 proteases by GW0385 and other arylsulfonamides. Biochemistry, 2004, Nov-16, Volume: 43, Issue:45 Topics: Amino Acid Substitution; Binding, Competitive; Carbamates; Chromatography, Affinity; Chromatography, Gel; Dextrans; Dimerization; Furans; HIV Protease; HIV Protease Inhibitors; HIV-1; Hydrolysis; Kinetics; Protein Binding; Saquinavir; Spectrometry, Fluorescence; Substrate Specificity; Sulfonamides	2004
Long-term effects of HIV-1 protease inhibitors on insulin secretion and insulin signaling in INS-1 beta cells. The Journal of endocrinology, 2004, Volume: 183, Issue:3 Topics: Carbamates; Cell Line; Furans; Glucose; HIV Protease Inhibitors; Humans; Indinavir; Insulin; Insulin Receptor Substrate Proteins; Insulin Secretion; Intracellular Signaling Peptides and Proteins; Islets of Langerhans; Nelfinavir; Phosphoproteins; Phosphorylation; Ritonavir; Saquinavir; Signal Transduction; Stimulation, Chemical; Sulfonamides; Time Factors	2004
Simple and simultaneous determination of the hiv-protease inhibitors amprenavir, atazanavir, indinavir, lopinavir, nelfinavir, ritonavir and saquinavir plus M8 nelfinavir metabolite and the nonnucleoside reverse transcriptase inhibitors efavirenz and nevi Therapeutic drug monitoring, 2005, Volume: 27, Issue:2 Topics: Alkynes; Atazanavir Sulfate; Benzoxazines; Calibration; Carbamates; Chromatography, Liquid; Cyclopropanes; Drug Stability; Furans; HIV Infections; HIV Protease Inhibitors; Humans; Indinavir; Lopinavir; Nelfinavir; Nevirapine; Oligopeptides; Oxazines; Pyridines; Pyrimidinones; Reproducibility of Results; Reverse Transcriptase Inhibitors; Ritonavir; Saquinavir; Specimen Handling; Spectrophotometry, Ultraviolet; Sulfonamides	2005
Evolution of resistance mutations pattern in HIV-1-infected patients during intensification therapy with a boosted protease inhibitor. AIDS (London, England), 2005, May-20, Volume: 19, Issue:8 Topics: Antiretroviral Therapy, Highly Active; Carbamates; Drug Resistance, Multiple, Viral; Follow-Up Studies; Furans; HIV Infections; HIV Protease; HIV Protease Inhibitors; HIV Reverse Transcriptase; HIV-1; Humans; Indinavir; Lopinavir; Mutation; Pyrimidinones; Ritonavir; Saquinavir; Sulfonamides; Treatment Failure; Viral Load	2005
Steady-state pharmacokinetics of atazanavir given alone or in combination with saquinavir hard-gel capsules or amprenavir in HIV-1-infected patients. European journal of clinical pharmacology, 2005, Volume: 61, Issue:7 Topics: Adult; Atazanavir Sulfate; Carbamates; Chromatography, High Pressure Liquid; Drug Therapy, Combination; Female; Furans; HIV Infections; HIV Protease Inhibitors; HIV-1; Humans; Male; Middle Aged; Oligopeptides; Pilot Projects; Pyridines; Saquinavir; Sulfonamides	2005
Effects of 5 HIV protease inhibitors on vasomotor function and superoxide anion production in porcine coronary arteries. Journal of acquired immune deficiency syndromes (1999), 2005, Sep-01, Volume: 40, Issue:1 Topics: Animals; Bradykinin; Carbamates; Coronary Vessels; Down-Regulation; Furans; HIV Protease Inhibitors; Indinavir; Methionine; Muscle Contraction; Muscle, Smooth, Vascular; Myography; Nelfinavir; Nitric Oxide Synthase; Organ Culture Techniques; Ritonavir; RNA, Messenger; Saquinavir; Selenium Compounds; Sulfonamides; Superoxides; Swine; Vasomotor System	2005
Differential inhibition of cytochrome P450 3A4, 3A5 and 3A7 by five human immunodeficiency virus (HIV) protease inhibitors in vitro. Basic & clinical pharmacology & toxicology, 2006, Volume: 98, Issue:1 Topics: Aryl Hydrocarbon Hydroxylases; Carbamates; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dose-Response Relationship, Drug; Drug Interactions; Furans; HIV Protease Inhibitors; Humans; Hydroxylation; In Vitro Techniques; Indinavir; Isoenzymes; Kinetics; Nelfinavir; Recombinant Proteins; Ritonavir; Saquinavir; Sulfonamides; Testosterone	2006
Gated binding of ligands to HIV-1 protease: Brownian dynamics simulations in a coarse-grained model. Biophysical journal, 2006, Jun-01, Volume: 90, Issue:11 Topics: Carbamates; Computer Simulation; Enzyme Activation; Furans; HIV Protease; HIV Protease Inhibitors; Indinavir; Ligands; Models, Molecular; Mutation; Saquinavir; Sulfonamides	2006
Prevalence of the HIV-1 protease mutation I47A in clinical practice and association with lopinavir resistance. AIDS (London, England), 2006, Apr-24, Volume: 20, Issue:7 Topics: Carbamates; Codon; Drug Resistance, Viral; Furans; Genotype; HIV Infections; HIV Protease Inhibitors; HIV-1; Humans; Indinavir; Lopinavir; Mutation; Nelfinavir; Phenotype; Pyrimidinones; Ritonavir; Saquinavir; Sulfonamides	2006
A novel approach for in-process monitoring and managing cross-contamination in a high-throughput high-performance liquid chromatography assay with tandem mass spectrometric detection. Rapid communications in mass spectrometry : RCM, 2006, Volume: 20, Issue:14 Topics: Biomarkers; Carbamates; Chemistry Techniques, Analytical; Chromatography, High Pressure Liquid; Drug Contamination; Furans; Humans; Lopinavir; Pyrimidinones; Quality Control; Reproducibility of Results; Ritonavir; Saquinavir; Sensitivity and Specificity; Sulfonamides; Tandem Mass Spectrometry	2006
Simultaneous determination of 8 HIV protease inhibitors in human plasma by isocratic high-performance liquid chromatography with combined use of UV and fluorescence detection: amprenavir, indinavir, atazanavir, ritonavir, lopinavir, saquinavir, nelfinavir Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2007, Jan-01, Volume: 845, Issue:1 Topics: Atazanavir Sulfate; Calibration; Carbamates; Chromatography, High Pressure Liquid; Drug Monitoring; Drug Stability; Fluorescence; Furans; HIV Protease Inhibitors; Humans; Indinavir; Lopinavir; Nelfinavir; Oligopeptides; Pyridines; Pyrimidinones; Reproducibility of Results; Ritonavir; Saquinavir; Sensitivity and Specificity; Sulfonamides; Ultraviolet Rays	2007
An isocratic liquid chromatography method for determining HIV non-nucleoside reverse transcriptase inhibitor and protease inhibitor concentrations in human plasma. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2007, Apr-01, Volume: 848, Issue:2 Topics: Alkynes; Atazanavir Sulfate; Benzoxazines; Carbamates; Chromatography, High Pressure Liquid; Cyclopropanes; Furans; HIV Protease Inhibitors; Humans; Indinavir; Lopinavir; Nelfinavir; Nevirapine; Oligopeptides; Pyridines; Pyrimidinones; Reproducibility of Results; Reverse Transcriptase Inhibitors; Ritonavir; Saquinavir; Spectrophotometry, Ultraviolet; Sulfonamides	2007
High-performance liquid chromatography assay for the determination of the HIV-protease inhibitor tipranavir in human plasma in combination with nine other antiretroviral medications. Journal of pharmaceutical and biomedical analysis, 2007, Mar-12, Volume: 43, Issue:4 Topics: Alkynes; Anti-HIV Agents; Atazanavir Sulfate; Benzoxazines; Carbamates; Chromatography, High Pressure Liquid; Cyclopropanes; Drug Stability; Furans; HIV Protease Inhibitors; Humans; Indinavir; Lopinavir; Molecular Structure; Nelfinavir; Nevirapine; Oligopeptides; Oxazines; Pyridines; Pyrimidinones; Pyrones; Reproducibility of Results; Ritonavir; Saquinavir; Sensitivity and Specificity; Spectrophotometry, Ultraviolet; Sulfonamides; Time Factors	2007
A double transgenic mouse model expressing human pregnane X receptor and cytochrome P450 3A4. Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:12 Topics: Animals; Carbamates; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Drug Interactions; Female; Furans; Gene Expression; Gene Expression Regulation; HIV Protease Inhibitors; Humans; Intestine, Small; Ketoconazole; Liver; Male; Mice; Mice, Knockout; Mice, Transgenic; Microsomes, Liver; Models, Animal; Nelfinavir; Pregnane X Receptor; Pregnenolone Carbonitrile; Receptors, Steroid; Rifampin; Saquinavir; Sex Characteristics; Sulfonamides	2008
Interactions of different inhibitors with active-site aspartyl residues of HIV-1 protease and possible relevance to pepsin. Proteins, 2009, May-15, Volume: 75, Issue:3 Topics: Atazanavir Sulfate; Binding Sites; Binding, Competitive; Calorimetry, Differential Scanning; Carbamates; Crystallography, X-Ray; Darunavir; Furans; HIV Protease; HIV Protease Inhibitors; Humans; Indinavir; Kinetics; Lopinavir; Models, Molecular; Molecular Structure; Mutation; Nelfinavir; Oligopeptides; Pepsin A; Protein Binding; Protein Structure, Tertiary; Pyridines; Pyrimidinones; Pyrones; Ritonavir; Saquinavir; Sulfonamides	2009
Quantification of 8 HIV-protease inhibitors and 2 nonnucleoside reverse transcriptase inhibitors by ultra-performance liquid chromatography with diode array detection. Clinical chemistry, 2009, Volume: 55, Issue:1 Topics: Alkynes; Atazanavir Sulfate; Benzoxazines; Carbamates; Chromatography, High Pressure Liquid; Cyclopropanes; Furans; HIV Protease Inhibitors; Humans; Indinavir; Lopinavir; Nelfinavir; Nevirapine; Oligopeptides; Pyridines; Pyrimidinones; Pyrones; Reproducibility of Results; Reverse Transcriptase Inhibitors; Ritonavir; Saquinavir; Sensitivity and Specificity; Solid Phase Extraction; Sulfonamides	2009
Interaction of eight HIV protease inhibitors with the canalicular efflux transporter ABCC2 (MRP2) in sandwich-cultured rat and human hepatocytes. Biopharmaceutics & drug disposition, 2010, Volume: 31, Issue:2-3 Topics: Animals; Anti-HIV Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Carbamates; Cells, Cultured; Fluoresceins; Furans; Hepatocytes; HIV Protease Inhibitors; Humans; Indinavir; Liver; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Nelfinavir; Rats; Rats, Wistar; Ritonavir; Saquinavir; Sulfonamides	2010
HIV-1 protease mutations and protease inhibitor cross-resistance. Antimicrobial agents and chemotherapy, 2010, Volume: 54, Issue:10 Topics: Atazanavir Sulfate; Carbamates; Darunavir; Furans; HIV Protease; HIV Protease Inhibitors; HIV-1; Indinavir; Least-Squares Analysis; Lopinavir; Mutation; Nelfinavir; Oligopeptides; Organophosphates; Polymorphism, Genetic; Pyridines; Pyrimidinones; Pyrones; Saquinavir; Sulfonamides	2010
Amprenavir complexes with HIV-1 protease and its drug-resistant mutants altering hydrophobic clusters. The FEBS journal, 2010, Volume: 277, Issue:18 Topics: Amino Acid Substitution; Carbamates; Crystallography, X-Ray; Dimerization; Drug Resistance, Multiple, Viral; Furans; HIV Protease; HIV Protease Inhibitors; HIV-1; Hydrophobic and Hydrophilic Interactions; Kinetics; Molecular Conformation; Mutation; Protein Binding; Protein Interaction Domains and Motifs; Saquinavir; Sulfonamides	2010
Changes in lipid profiles after switching to a protease inhibitor-containing cART--unfavourable effect of fosamprenavir in obese patients. European journal of medical research, 2011, Feb-24, Volume: 16, Issue:2 Topics: Adult; Atazanavir Sulfate; Carbamates; Cholesterol; Cohort Studies; Female; Furans; HIV Infections; HIV Protease Inhibitors; Humans; Lipid Metabolism; Male; Middle Aged; Oligopeptides; Organophosphates; Pyridines; Retrospective Studies; Saquinavir; Sulfonamides	2011
In vitro activity of antiretroviral drugs against Plasmodium falciparum. Antimicrobial agents and chemotherapy, 2011, Volume: 55, Issue:11 Topics: Alkynes; Animals; Anti-Retroviral Agents; Antimalarials; Benzoxazines; Carbamates; Cyclopropanes; Darunavir; Furans; Lopinavir; Nelfinavir; Nevirapine; Plasmodium falciparum; Pyridines; Pyrones; Ritonavir; Saquinavir; Sulfonamides	2011
Prediction and in vitro evaluation of selected protease inhibitor antiviral drugs as inhibitors of carboxylesterase 1: a potential source of drug-drug interactions. Pharmaceutical research, 2012, Volume: 29, Issue:4 Topics: Antiviral Agents; Atazanavir Sulfate; Carbamates; Carboxylic Ester Hydrolases; Drug Interactions; Furans; Humans; Kinetics; Models, Molecular; Nelfinavir; Oligopeptides; Protease Inhibitors; Pyridines; Quantitative Structure-Activity Relationship; Ritonavir; Saquinavir; Sulfonamides	2012
Critical differences in HIV-1 and HIV-2 protease specificity for clinical inhibitors. Protein science : a publication of the Protein Society, 2012, Volume: 21, Issue:3 Topics: Amino Acid Sequence; Binding Sites; Carbamates; Crystallography, X-Ray; Darunavir; Furans; HIV Protease; HIV Protease Inhibitors; HIV-1; HIV-2; Kinetics; Saquinavir; Sulfonamides	2012
Role of FAP48 in HIV-associated lipodystrophy. Journal of cellular biochemistry, 2012, Volume: 113, Issue:11 Topics: Adaptor Proteins, Signal Transducing; Adipocytes; Alkynes; Animals; Antiretroviral Therapy, Highly Active; Benzoxazines; Calcineurin; Carbamates; Cell Differentiation; Cell Line; Cyclopropanes; Furans; Gene Expression; Glucocorticoids; HIV-1; HIV-Associated Lipodystrophy Syndrome; Humans; Indinavir; Mice; Saquinavir; Signal Transduction; Stavudine; Sulfonamides; Transfection	2012
A contribution to the drug resistance mechanism of darunavir, amprenavir, indinavir, and saquinavir complexes with HIV-1 protease due to flap mutation I50V: a systematic MM-PBSA and thermodynamic integration study. Journal of chemical information and modeling, 2013, Aug-26, Volume: 53, Issue:8 Topics: Anti-HIV Agents; Carbamates; Cluster Analysis; Darunavir; Drug Resistance, Viral; Furans; HIV Protease; HIV Protease Inhibitors; HIV-1; Hydrogen Bonding; Indinavir; Molecular Dynamics Simulation; Mutation; Protein Conformation; Saquinavir; Sulfonamides; Thermodynamics	2013
In vitro OATP1B1 and OATP1B3 inhibition is associated with observations of benign clinical unconjugated hyperbilirubinemia. Xenobiotica; the fate of foreign compounds in biological systems, 2014, Volume: 44, Issue:3 Topics: Antirheumatic Agents; Atazanavir Sulfate; Bilirubin; Carbamates; Cyclosporine; Furans; Glucuronosyltransferase; HIV Protease Inhibitors; Hyperbilirubinemia; In Vitro Techniques; Indinavir; Liver-Specific Organic Anion Transporter 1; Oligopeptides; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Pyridines; Rifampin; Rifamycins; Saquinavir; Solute Carrier Organic Anion Transporter Family Member 1B3; Sulfonamides	2014
GRL-04810 and GRL-05010, difluoride-containing nonpeptidic HIV-1 protease inhibitors (PIs) that inhibit the replication of multi-PI-resistant HIV-1 in vitro and possess favorable lipophilicity that may allow blood-brain barrier penetration. Antimicrobial agents and chemotherapy, 2013, Volume: 57, Issue:12 Topics: Animals; Astrocytes; Atazanavir Sulfate; Blood-Brain Barrier; Carbamates; Cell Line; Darunavir; Drug Resistance, Multiple, Viral; Endothelial Cells; Fluorides; Haplorhini; HIV Protease; HIV Protease Inhibitors; HIV-1; Humans; Hydrophobic and Hydrophilic Interactions; Lopinavir; Models, Biological; Molecular Docking Simulation; Oligopeptides; Pericytes; Pyridines; Rats; Saquinavir; Sulfonamides; T-Lymphocytes; Virus Replication	2013
Decoding the anti-Trypanosoma cruzi action of HIV peptidase inhibitors using epimastigotes as a model. PloS one, 2014, Volume: 9, Issue:12 Topics: Animals; Anti-HIV Agents; Aspartic Acid Proteases; Carbamates; Furans; Host-Parasite Interactions; Indinavir; Insect Vectors; Lopinavir; Microscopy, Electron, Transmission; Nelfinavir; Protease Inhibitors; Ritonavir; Saquinavir; Sulfonamides; Trypanocidal Agents; Trypanosoma cruzi	2014
Anti-HIV and Anti-Hepatitis C Virus Drugs Inhibit P-Glycoprotein Efflux Activity in Caco-2 Cells and Precision-Cut Rat and Human Intestinal Slices. Antimicrobial agents and chemotherapy, 2019, Volume: 63, Issue:11 Topics: Aged; Animals; Anti-HIV Agents; Antiviral Agents; Atazanavir Sulfate; ATP Binding Cassette Transporter, Subfamily B, Member 1; Benzimidazoles; Caco-2 Cells; Carbamates; Drug Interactions; Female; Fluorenes; Hepatitis C; HIV Infections; Humans; Imidazoles; Intestines; Lopinavir; Male; Maraviroc; Middle Aged; Pyrrolidines; Rats; Rats, Wistar; Ritonavir; Saquinavir; Valine; Zidovudine	2019