carbamates has been researched along with rwj-333369 in 40 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 21 (52.50) | 29.6817 |
| 2010's | 18 (45.00) | 24.3611 |
| 2020's | 1 (2.50) | 2.80 |
| Authors | Studies |
|---|---|
| Bialer, M; Bockx, M; Chien, S; Goris, I; Hendrickx, J; Janssen, CG; Kao, M; Kelley, MF; Mannens, GS; Meuldermans, W; Van Hoof, B; Verhaeghe, T; Verreet, B | 1 |
| Kelley, M; Klein, B; Novak, GP; Zannikos, P | 1 |
| Annaert, P; Bockx, M; Goris, I; Hendrickx, J; Janssen, CG; Kao, M; Kelley, MF; Mamidi, RN; Mannens, G; Meuldermans, W | 1 |
| Bialer, M; Chien, S; Doose, DR; Mertens, A; Novak, G; Solanki, B; Verhaeghe, T; Yao, C | 1 |
| Abou-Khalil, BW; French, JA; Gibson, D; Grosse, PA; Guerrini, R; Hirsch, E; Macher, JP; Meyer, BU; Novak, GP; Parmeggiani, L; Rosenfeld, WE; Schmidt, B; Trenité, DG; van Gerven, J | 1 |
| Dichter, M; Keck, CA; LeBold, DG; McIntosh, TK; Morales, DM; Pitkänen, A; Plevy, JB; Puri, R; Thompson, HJ; Zhao, B | 1 |
| Boehrer, A; François, J; Nehlig, A | 1 |
| Kulig, K; Malawska, B | 1 |
| Levy, R; Novak, G; Ragueneau-Majlessi, I; Solanki, B; Yao, C; Zannikos, P | 1 |
| DeLorenzo, RJ; Deshpande, LS; Nagarkatti, N; Sombati, S | 1 |
| DeLorenzo, RJ; Deshpande, LS; Nagarkatti, N; Sombati, S; Ziobro, JM | 1 |
| Dudek, FE; Grabenstatter, HL | 1 |
| Deng, Z; Hwang, H; Kim, YJ; Varasteh, M; Wong, GB | 1 |
| Faught, E; Greenspan, A; Haas, M; Holmes, GL; Neto, W; Novak, G; Reines, S; Rosenfeld, WE; Schmitt, J; Yuen, E | 1 |
| Brenneman, DE; Flores, CM; Hutchinson, TL; Liu, Y; Wang, Y; Yohrling, GJ; Zhao, B | 1 |
| Dong, GR; Jung, YH; Kim, IS; Li, QR; Woo, SH | 1 |
| Cady, RK; Diener, HC; Haas, M; Hu, P; Mathew, N; Novak, GP | 1 |
| Constanti, A; Stephens, GJ; Whalley, BJ | 1 |
| Levin, ED; Overstreet, DH; Rezvani, AH; Vaidya, AH; Zhao, B | 1 |
| Bialer, M; Franc, MA; Novak, G; Solanki, B; Verhaeghe, T; Yao, C; Zannikos, P | 1 |
| Cook, T; Cramer, JA; Greenspan, A; Haas, M; Halford, JJ; Kälviäinen, R; Kwan, P; Novak, G; Schmitt, J; Sperling, MR; Yuen, E | 1 |
| Perucca, E | 1 |
| Ascher, S; Biondi, DM; Elble, RJ; Hulihan, J; Wiegand, F | 1 |
| Curia, G; D'Ambrosio, R; Eastman, CL; Fender, JS; Nov, E; Stewart, TH; Verley, DR | 1 |
| Ben-Menachem, E; Eerdekens, M; Halford, JJ; Kwan, P; Ness, S; Novak, G; Schmitt, J | 1 |
| Brashear, HR; Greenspan, A; Moore, K; Solanki, B; Verhaeghe, T; Zannikos, P | 1 |
| Galanopoulou, AS; Moshé, SL; Ono, T | 1 |
| Lee, CY; Lee, ML; Liou, HH; Shih, CC | 1 |
| Brashear, HR; Meador, KJ; Novak, G; Wiegand, F; Zannikos, P | 1 |
| Ariyawansa, J; Brashear, HR; DiBernardo, A; Gonzalez, M; Zannikos, P | 1 |
| Arolfo, MP; Lawrence, AJ; Levin, ED; Overstreet, DH; Rezvani, AH | 1 |
| Ramakrishna, K; Rao, RN; Santhakumar, K; Sravan, B | 1 |
| Akimana, G; Carneiro, JE; Cassel, JC; Cosquer, B; Faure, JB; Ferrandon, A; Geiger, K; Koning, E; Nehlig, A; Penazzi, L | 1 |
| Brashear, HR; DiBernardo, A; Ford, LM; Shi, Y; Smith, T; Todd, MJ | 1 |
| Blier, P; El Mansari, M; Shim, S | 1 |
| Akimana, G; Barbelivien, A; Cassel, JC; Cosquer, B; Faure, JB; Ferrandon, A; Herbeaux, K; Koning, E; Marques-Carneiro, JE; Nehlig, A | 1 |
| Amorim, RP; Araujo, MG; Carneiro, JE; Fernandes, MJ; Nehlig, A | 1 |
| Harris, TJ; Kellogg, RG; Mangubat, EZ; Rossi, MA | 1 |
| Bhamidipati, RK; Mullangi, R; Srinivas, NR | 1 |
| Bresnahan, R; Cao, Y; Lu, C; Martin-McGill, KJ; Zheng, J | 1 |
5 review(s) available for carbamates and rwj-333369
| Article | Year |
|---|---|
Carisbamate (RWJ-333369).
Topics: Animals; Anticonvulsants; Carbamates; Clinical Trials as Topic; Epilepsy; Humans | 2007 |
What is the promise of new antiepileptic drugs in status epilepticus? Focus on brivaracetam, carisbamate, lacosamide, NS-1209, and topiramate.
Topics: Acetamides; Animals; Anticonvulsants; Carbamates; Disease Models, Animal; Fructose; Humans; Lacosamide; Pyrroles; Pyrrolidinones; Rats; Receptors, AMPA; Status Epilepticus; Tetrahydroisoquinolines; Topiramate; Treatment Outcome | 2009 |
Novel medication targets for the treatment of alcoholism: preclinical studies.
Topics: Alcohol Deterrents; Alcoholism; Animals; Azepines; Azetidines; Carbamates; Disease Models, Animal; Drug Evaluation, Preclinical; Drugs, Investigational; Humans; Isoflavones; Molecular Targeted Therapy; Patents as Topic; Piperidines; Pyridines; Synaptic Transmission | 2012 |
Neuroprotective agents and modulation of temporal lobe epilepsy.
Topics: Anticonvulsants; Carbamates; Epilepsy, Temporal Lobe; Erythropoietin; Humans; Neuroprotective Agents; Purinergic P1 Receptor Agonists | 2015 |
Carisbamate add-on therapy for drug-resistant focal epilepsy.
Topics: Adult; Anticonvulsants; Carbamates; Drug Resistant Epilepsy; Drug Therapy, Combination; Epilepsies, Partial; Humans; Pharmaceutical Preparations; Randomized Controlled Trials as Topic | 2021 |
12 trial(s) available for carbamates and rwj-333369
| Article | Year |
|---|---|
The absorption, metabolism, and excretion of the novel neuromodulator RWJ-333369 (1,2-ethanediol, [1-2-chlorophenyl]-, 2-carbamate, [S]-) in humans.
Topics: Administration, Oral; Adult; Anticonvulsants; Biotransformation; Carbamates; Chromatography, High Pressure Liquid; Feces; Glucuronides; Humans; Hydrolysis; Intestinal Absorption; Kidney; Male; Middle Aged; Molecular Structure; Oxidation-Reduction; Reference Values; Sulfuric Acid Esters; Tandem Mass Spectrometry; Uridine Diphosphate Glucuronic Acid | 2007 |
Evaluation of carisbamate, a novel antiepileptic drug, in photosensitive patients: an exploratory, placebo-controlled study.
Topics: Adolescent; Adult; Affect; Anticonvulsants; Carbamates; Depression; Dose-Response Relationship, Drug; Epilepsy, Reflex; Female; Humans; Male; Middle Aged; Photic Stimulation; Psychiatric Status Rating Scales | 2007 |
Pharmacokinetics, safety, and tolerability of the new antiepileptic carisbamate in the elderly.
Topics: Administration, Oral; Adult; Age Factors; Aged; Aging; Anticonvulsants; Area Under Curve; Carbamates; Confidence Intervals; Dose-Response Relationship, Drug; Double-Blind Method; Drug Administration Schedule; Drug Evaluation; Drug Tolerance; Female; Humans; Male; Middle Aged | 2008 |
Randomized, controlled, dose-ranging trial of carisbamate for partial-onset seizures.
Topics: Adolescent; Adult; Aged; Alanine Transaminase; Anticonvulsants; Body Weight; Carbamates; Dose-Response Relationship, Drug; Double-Blind Method; Drug Evaluation; Epilepsies, Partial; Female; Humans; Male; Middle Aged; Retrospective Studies; Treatment Outcome; Young Adult | 2008 |
Evaluation of carisbamate for the treatment of migraine in a randomized, double-blind trial.
Topics: Adolescent; Adult; Analgesics; Carbamates; Dose-Response Relationship, Drug; Double-Blind Method; Female; Humans; Male; Middle Aged; Migraine Disorders | 2009 |
Carisbamate as adjunctive treatment of partial onset seizures in adults in two randomized, placebo-controlled trials.
Topics: Adolescent; Adult; Aged; Anticonvulsants; Carbamates; Dizziness; Dose-Response Relationship, Drug; Double-Blind Method; Drug Administration Schedule; Drug Therapy, Combination; Epilepsies, Partial; Female; Glucuronosyltransferase; Humans; Male; Middle Aged; Placebos; Sleep; Treatment Outcome | 2010 |
Carisbamate in essential tremor: brief report of a proof of concept study.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anticonvulsants; Carbamates; Cross-Over Studies; Double-Blind Method; Essential Tremor; Female; Humans; Male; Middle Aged; Severity of Illness Index; Young Adult | 2010 |
A randomized, double-blind, placebo-controlled study of the efficacy, safety, and tolerability of adjunctive carisbamate treatment in patients with partial-onset seizures.
Topics: Adult; Anticonvulsants; Carbamates; Double-Blind Method; Drug Administration Schedule; Drug Therapy, Combination; Epilepsies, Partial; Female; Humans; Male; Middle Aged; Outcome Assessment, Health Care | 2011 |
Effect of mild and moderate hepatic impairment on the pharmacokinetics and safety of carisbamate.
Topics: Administration, Oral; Adult; Aged; Analgesics; Anticonvulsants; Area Under Curve; Biotransformation; Carbamates; Female; Germany; Glucuronides; Half-Life; Humans; Linear Models; Liver; Liver Cirrhosis; Male; Metabolic Clearance Rate; Middle Aged; Models, Biological; Protein Binding; Severity of Illness Index | 2012 |
Cognitive effects of carisbamate in randomized, placebo-controlled, healthy-volunteer, multidose studies.
Topics: Anticonvulsants; Arousal; Carbamates; Choice Behavior; Cognition Disorders; Cross-Over Studies; Dose-Response Relationship, Drug; Double-Blind Method; Female; Humans; Male; Memory; Neuropsychological Tests; Photic Stimulation; Reaction Time; Time Factors | 2011 |
Effect of carisbamate on the pharmacokinetics and pharmacodynamics of warfarin in healthy participants.
Topics: Adult; Anticoagulants; Carbamates; Female; Humans; International Normalized Ratio; Male; Middle Aged; Neurotransmitter Agents; Prothrombin Time; Warfarin; Young Adult | 2012 |
Efficacy and safety of carisbamate in patients with diabetic neuropathy or postherpetic neuralgia: results from 3 randomized, double-blind placebo-controlled trials.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Carbamates; Diabetic Neuropathies; Double-Blind Method; Female; Follow-Up Studies; Humans; Male; Middle Aged; Neuralgia, Postherpetic; Neurotransmitter Agents; Pain Measurement; Severity of Illness Index; Treatment Outcome; Young Adult | 2014 |
23 other study(ies) available for carbamates and rwj-333369
| Article | Year |
|---|---|
Metabolism and excretion of RWJ-333369 [1,2-ethanediol, 1-(2-chlorophenyl)-, 2-carbamate, (S)-] in mice, rats, rabbits, and dogs.
Topics: Administration, Oral; Animals; Anticonvulsants; Biotransformation; Carbamates; Carbon Radioisotopes; Chromatography, High Pressure Liquid; Dogs; Feces; Female; Glucuronides; Hydrolysis; Kidney; Male; Mice; Molecular Structure; Oxidation-Reduction; Rabbits; Rats; Rats, Sprague-Dawley; Scintillation Counting; Sulfuric Acid Esters; Tandem Mass Spectrometry | 2007 |
An interaction study between the new antiepileptic and CNS drug carisbamate (RWJ-333369) and lamotrigine and valproic acid.
Topics: Anticonvulsants; Area Under Curve; Carbamates; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Interactions; Humans; Lamotrigine; Triazines; Valproic Acid | 2007 |
The novel antiepileptic agent RWJ-333369-A, but not its analog RWJ-333369, reduces regional cerebral edema without affecting neurobehavioral outcome or cell death following experimental traumatic brain injury.
Topics: Animals; Anticonvulsants; Behavior, Animal; Brain Edema; Brain Injuries; Carbamates; Cell Death; Cognition; Male; Maze Learning; Motor Activity; Nervous System; Psychomotor Performance; Rats; Rats, Sprague-Dawley; Swimming | 2007 |
Effects of carisbamate (RWJ-333369) in two models of genetically determined generalized epilepsy, the GAERS and the audiogenic Wistar AS.
Topics: Animals; Anticonvulsants; Behavior, Animal; Carbamates; Cerebral Cortex; Disease Models, Animal; Dose-Response Relationship, Drug; Electroencephalography; Epilepsy, Absence; Epilepsy, Generalized; Epilepsy, Reflex; Frontal Lobe; Fructose; Male; Motor Activity; Parietal Lobe; Rats; Rats, Wistar; Reaction Time; Species Specificity; Topiramate | 2008 |
Carisbamate, a new carbamate for the treatment of epilepsy.
Topics: Animals; Anticonvulsants; Carbamates; Controlled Clinical Trials as Topic; Disease Models, Animal; Drug Evaluation, Preclinical; Epilepsy; Humans; Patents as Topic | 2007 |
The novel antiepileptic drug carisbamate (RWJ 333369) is effective in inhibiting spontaneous recurrent seizure discharges and blocking sustained repetitive firing in cultured hippocampal neurons.
Topics: Animals; Anticonvulsants; Carbamates; Cells, Cultured; Data Interpretation, Statistical; Dose-Response Relationship, Drug; Electrophysiology; Ethosuximide; Hippocampus; Magnesium Deficiency; Neurons; Patch-Clamp Techniques; Phenytoin; Rats; Rats, Sprague-Dawley; Seizures; Status Epilepticus | 2008 |
Carisbamate prevents the development and expression of spontaneous recurrent epileptiform discharges and is neuroprotective in cultured hippocampal neurons.
Topics: Action Potentials; Analysis of Variance; Animals; Animals, Newborn; Anticonvulsants; Carbamates; Cell Death; Cells, Cultured; Epilepsy; Hippocampus; Magnesium; Neurons; Patch-Clamp Techniques; Phenobarbital; Rats; Rats, Sprague-Dawley | 2008 |
A new potential AED, carisbamate, substantially reduces spontaneous motor seizures in rats with kainate-induced epilepsy.
Topics: Analysis of Variance; Animals; Anticonvulsants; Carbamates; Cross-Over Studies; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Schedule; Epilepsy; Fructose; Kainic Acid; Male; Rats; Rats, Sprague-Dawley; Seizures; Time Factors; Topiramate; Video Recording | 2008 |
Quantitative determination of polymorphic impurity by X-ray powder diffractometry in an OROS formulation.
Topics: Anticonvulsants; Carbamates; Chemistry, Pharmaceutical; Crystallization; Delayed-Action Preparations; Drug Stability; Drug Storage; Osmosis; Tablets; Temperature; Thermodynamics; X-Ray Diffraction | 2009 |
Carisbamate, a novel neuromodulator, inhibits voltage-gated sodium channels and action potential firing of rat hippocampal neurons.
Topics: Action Potentials; Animals; Anticonvulsants; Carbamates; Cell Line; Cricetinae; Cricetulus; Dose-Response Relationship, Drug; Electrophysiology; Female; Fibroblasts; Hippocampus; Membrane Potentials; Neurons; Patch-Clamp Techniques; Phenytoin; Pregnancy; Rats; Rats, Sprague-Dawley; Sodium Channel Blockers | 2009 |
One-pot conversion of trimethylsilyl ethers into urethanes using chlorosulfonyl isocyanate: application to the synthesis of a novel neuromodulator carisbamate.
Topics: Alkenes; Carbamates; Indicators and Reagents; Isocyanates; Trimethylsilyl Compounds; Urethane | 2008 |
Investigation of the effects of the novel anticonvulsant compound carisbamate (RWJ-333369) on rat piriform cortical neurones in vitro.
Topics: Action Potentials; Animals; Anticonvulsants; Calcium; Carbamates; Cell Membrane; Chloride Channels; Convulsants; Culture Media; Excitatory Postsynaptic Potentials; Female; In Vitro Techniques; Lidocaine; Male; Neurons; Olfactory Pathways; Patch-Clamp Techniques; Pyrimidines; Rats; Rats, Wistar; Sodium Channels | 2009 |
Carisbamate, a novel antiepileptic candidate compound, attenuates alcohol intake in alcohol-preferring rats.
Topics: Administration, Oral; Alcohol Drinking; Animals; Anticonvulsants; Carbamates; Disease Models, Animal; Dose-Response Relationship, Drug; Male; Rats; Time Factors | 2009 |
Pharmacokinetics of carisbamate (RWJ-333369) in healthy Japanese and Western subjects.
Topics: Adolescent; Adult; Analysis of Variance; Anticonvulsants; Area Under Curve; Asian People; Calibration; Carbamates; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Half-Life; Humans; Male; Pharmacogenetics; Reference Values; Tandem Mass Spectrometry; Time Factors; White People; Young Adult | 2009 |
Antiepileptic and antiepileptogenic performance of carisbamate after head injury in the rat: blind and randomized studies.
Topics: Animals; Anticonvulsants; Carbamates; Craniocerebral Trauma; Epilepsy, Post-Traumatic; Male; Pilot Projects; Random Allocation; Rats; Rats, Sprague-Dawley; Single-Blind Method | 2011 |
Carisbamate acutely suppresses spasms in a rat model of symptomatic infantile spasms.
Topics: Animals; Animals, Newborn; Anticonvulsants; Behavior, Animal; Carbamates; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Humans; Infant; Infant, Newborn; Male; Phenytoin; Pregnancy; Rats; Rats, Sprague-Dawley; Spasm; Spasms, Infantile | 2011 |
Carisbamate (RWJ-333369) inhibits glutamate transmission in the granule cell of the dentate gyrus.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Anticonvulsants; Biophysics; Calcium Channel Blockers; Carbamates; Dentate Gyrus; Dose-Response Relationship, Drug; Drug Interactions; Electric Stimulation; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; GABA Antagonists; Glutamic Acid; In Vitro Techniques; Male; Neurons; omega-Conotoxin GVIA; Patch-Clamp Techniques; Picrotoxin; Rats; Rats, Wistar; Synaptic Transmission | 2011 |
RP-HPLC separation and ESI-MS, 1H, and 13C NMR characterization of forced degradants including process related impurities of carisbamate: method development and validation.
Topics: Carbamates; Chromatography, High Pressure Liquid; Drug Contamination; Hydrogen Peroxide; Hydrogen-Ion Concentration; Hydrolysis; Magnetic Resonance Spectroscopy; Photolysis; Sensitivity and Specificity; Spectrometry, Mass, Electrospray Ionization | 2013 |
A comprehensive behavioral evaluation in the lithium-pilocarpine model in rats: effects of carisbamate administration during status epilepticus.
Topics: Animals; Anticonvulsants; Antipsychotic Agents; Behavior, Animal; Brain; Carbamates; Cell Count; Disease Models, Animal; Lithium; Male; Maze Learning; Memory; Mossy Fibers, Hippocampal; Muscarinic Agonists; Neurons; Phosphopyruvate Hydratase; Pilocarpine; Rats; Rats, Sprague-Dawley; Status Epilepticus; Visual Perception | 2013 |
Modulation of the antidepressant-like effects of sustained administration of carisbamate and lamotrigine on monoaminergic systems: electrophysiological studies in the rat brain.
Topics: Animals; Antidepressive Agents; Biogenic Monoamines; Brain; CA3 Region, Hippocampal; Carbamates; Dose-Response Relationship, Drug; Lamotrigine; Locus Coeruleus; Male; Neurons; Raphe Nuclei; Rats; Rats, Sprague-Dawley; Synaptic Potentials; Triazines; Ventral Tegmental Area | 2013 |
Attention and executive functions in a rat model of chronic epilepsy.
Topics: Animals; Anticonvulsants; Attention; Brain; Brain Mapping; Carbamates; Cell Count; Disease Models, Animal; Epilepsy, Complex Partial; Epilepsy, Temporal Lobe; Executive Function; Inhibition, Psychological; Lithium Carbonate; Neurons; Pattern Recognition, Visual; Pilocarpine; Rats; Rats, Sprague-Dawley; Reaction Time; Serial Learning; Status Epilepticus | 2014 |
On-demand pulsatile intracerebral delivery of carisbamate with closed-loop direct neurostimulation therapy in an electrically induced self-sustained focal-onset epilepsy rat model.
Topics: Animals; Anticonvulsants; Carbamates; Combined Modality Therapy; Disease Models, Animal; Electric Stimulation Therapy; Epilepsies, Partial; Male; Rats; Rats, Inbred F344; Treatment Outcome | 2015 |
Interspecies scaling of urinary excretory amounts of nine drugs belonging to different therapeutic areas with diverse chemical structures - accurate prediction of the human urinary excretory amounts.
Topics: Animals; Benzodiazepines; Carbamates; Carbazoles; Cephapirin; Humans; Indoles; Labetalol; Nevirapine; Olanzapine; Pharmaceutical Preparations; Piperidines; Prospective Studies; Pyrimidines; Pyrroles; Species Specificity; Voriconazole | 2017 |