carbamates has been researched along with repaglinide in 540 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 69 (12.78) | 18.2507 |
| 2000's | 236 (43.70) | 29.6817 |
| 2010's | 208 (38.52) | 24.3611 |
| 2020's | 27 (5.00) | 2.80 |
| Authors | Studies |
|---|---|
| Beschke, K; Greischel, A; Rapp, H; Roth, W | 1 |
| Bakkali-Nadi, A; Malaisse, WJ; Malaisse-Lagae, F | 2 |
| Ampudia-Blasco, FJ; Bender, R; Berger, M; Heinemann, L; Heise, T; Schmidt, A; Starke, AA | 1 |
| Kruseman, AC; Menheere, PP; Müller, PG; Nijst, L; Sels, JP; Wolffenbuttel, BH | 1 |
| Dissing, S; Frøkjaer-Jensen, J; Gromada, J; Kofod, H | 1 |
| Brasseur, R; Lins, L; Malaisse, WJ | 1 |
| Malaisse, WJ | 4 |
| Bakkali Nadi, A; Malaisse, WJ; Zhang, TM | 1 |
| Kikuchi, M | 2 |
| Grell, W; Mark, M | 1 |
| Fuhlendorff, J; Ladrière, L; Malaisse, WJ; Malaisse-Lagae, F | 2 |
| Kaku, K | 1 |
| Björkling, F; García-Martínez, JA; Malaisse, WJ; Valverde, I; Villanueva-Peñacarrillo, ML | 1 |
| Brand, CL; Carr, RD; Fuhlendorff, J; Kofod, H; MacKay, P; Rolin, B; Rorsman, P; Shymko, R | 1 |
| Jijakli, H; Louchami, K; Malaisse, WJ; Sener, A | 1 |
| Ladrière, L; Laghmich, A; Malaisse, WJ; Malaisse-Lagae, F | 1 |
| Fuhlendorff, J; Ladrière, L; Leclercq-Meyer, V; Malaisse, WJ | 1 |
| Guanci, R; Lilley, LL | 1 |
| Balfour, JA; Faulds, D | 1 |
| Jijakli, H; Ladrière, L; Louchami, K; Malaisse, WJ | 1 |
| Brodows, RG; Damsbo, P; Einhorn, D; Goldberg, RB; Huang, WC; Lucas, CP; Rendell, MS; Strange, P | 1 |
| Lardinois, CK | 1 |
| Spiller, HA | 1 |
| Grell, W; Griss, G; Hurnaus, R; Luger, P; Mark, M; Müller, P; Nar, H; Rupprecht, E; Sauter, R; Wittneben, H | 1 |
| Owens, DR | 2 |
| Morley, JE | 1 |
| Hatorp, V; Oliver, S; Su, CA | 1 |
| Mooradian, AD; Thurman, JE | 1 |
| Landgraf, R; Wolffenbuttel, BH | 1 |
| Hatorp, V; Huang, WC; Strange, P | 2 |
| Clauson, P; Damsbo, P; Marbury, TC; Windfeld, K | 1 |
| Boyages, S; Carter, J; Colagiuri, S; Donnelly, T; Hopkins, H; Kidson, W; Moffitt, P; Moses, R; Slobodniuk, R | 1 |
| Huang, WC; Lebovitz, H; Marbury, T; Strange, P | 1 |
| Bilo, HJ; Landgraf, R; Müller, PG | 1 |
| DeFronzo, RA | 1 |
| Cai, Z; Lansdell, KA; Sheppard, DN | 1 |
| Clauson, P; Damsbo, P; Hatorp, V; Marbury, TC; Müller, PG | 1 |
| De Merbel, NC; Hansen, KT; Hatorp, V; Jonkman, JH; Kramer Nielsen, K; Oosterhuis, B; van Heiningen, PN; van Lier, JJ | 1 |
| Gomis, R | 1 |
| Moses, R | 5 |
| Schatz, H | 1 |
| Feinglos, MN; Hughes, AT; Luna, B | 1 |
| Dunning, BE; Hu, S; Wang, S | 3 |
| Smits, P; Tack, CJ | 1 |
| Wolffenbuttel, BH | 1 |
| Bokvist, K; Buschard, K; Gromada, J; Holst, JJ; Hoy, M; Thomsen, MK | 1 |
| Kuritzky, L; Quillen, DM; Samraj, GP | 1 |
| Dailey, G; Goldstein, BJ; Huang, WC; Jovanovic, L; Strange, P | 1 |
| Brillon, D; Brown, DL | 1 |
| Kolaczynski, JW | 1 |
| Mozersky, RP | 1 |
| Christensen, MS; Hatorp, V; Haug-Pihale, G; Walther, KH | 1 |
| Hatorp, V; Thomsen, MS | 1 |
| Andersen, MP; Hatorp, V; Huang, WC; Marbury, TC; Nielsen, KK; Ruckle, JL; Strange, P | 1 |
| Larmore, SS | 1 |
| Thomsen, MK | 1 |
| Owens, D | 2 |
| Nattrass, M | 1 |
| Bailey, CJ; Nattrass, M | 1 |
| Riddle, M | 1 |
| Bell, PA; Boettcher, BR; Dunning, BE; Fanelli, B; Geisse, S; Hu, S; Schmitz, R; Wang, S | 1 |
| Dejgaard, A; Hollingdal, M; Juhl, CB; Pincus, S; Pørksen, N; Schmitz, O; Sturis, J; Veldhuis, JD | 1 |
| Bayer, T; Ismail, I; Luzio, SD; Owens, DR | 1 |
| Güttner, J; Viertel, B | 1 |
| Jansen, JA; Müller, LK; Plum, A | 1 |
| Berger, S; Jovanovic, L; Raskin, P; Ratner, R; Schwartz, S; Woo, V | 1 |
| Füchtenbusch, M; Schatz, H; Standl, E | 1 |
| Landgraf, R | 2 |
| Damsbo, P; Massi-Benedetti, M | 1 |
| Lauritzen, T; Nattrass, M | 1 |
| Garber, AJ | 1 |
| Bauer, C; Dieken, ML; Frank, M; Landgraf, R | 1 |
| Backman, JT; Kivistö, KT; Neuvonen, M; Neuvonen, PJ; Niemi, M | 1 |
| Carlton, FB | 1 |
| Brennan, R; Csako, G; Gorden, P; Hirshberg, B; Pucino, F; Skarulis, MC | 1 |
| Dedov, I; Frandsen, KB; Gomis, R; Moses, RG; Schlienger, JL | 1 |
| Kalbag, JB; McLeod, JF; Nedelman, JR; Walter, YH | 1 |
| Blackburn, G | 1 |
| McDougall, A; Owens, DR | 1 |
| Menon, PS | 1 |
| Kock, M | 1 |
| de Souza, CJ; Dunning, BE; Lozito, R; Russo, P | 1 |
| Quast, U | 1 |
| Abbasi, I; Hasslacher, C; Hatorp, V; Sattler, K; Schumacher, S; Sieber, J; Weise, D | 1 |
| Ashcroft, FM; Dabrowski, M; Holmes, WE; Wahl, P | 1 |
| Laws, A | 1 |
| Kivistö, KT; Neuvonen, PJ; Niemi, M | 1 |
| Goldberg, RB; Strange, P | 1 |
| Dunning, BE; Foley, JE; Pratley, RE | 1 |
| Dejgaard, A; Kilhovd, B; Lager, I; Madsbad, S; Mustajoki, P | 1 |
| Boccuzzi, SJ; Fox, J; Kim, J; Shah, AB; Sung, JC; Wogen, J | 1 |
| Goldberg, RB; Graf, RJ; Huang, WC; Marbury, TC; Polvino, W; Schwartz, SL; Strange, P; Weston, I | 1 |
| Schade, DS | 1 |
| Grodsky, GM | 1 |
| De Leeuw, IH; Van Acker, KL; Van Gaal, LF | 1 |
| Scheen, AJ | 2 |
| Rutten, GE | 1 |
| Calvo Romero, JM; Lima Rodríguez, EM | 1 |
| Hu, S; Wang, S | 1 |
| Milla, C; Moran, A; Phillips, J | 1 |
| Aller, R; Cuellar, L; de Luis, DA; Izaola, O; Ovalle, H; Romero, E; Terroba, C | 1 |
| Culy, CR; Jarvis, B | 1 |
| Sternon, J | 1 |
| Pospísilová, Y | 1 |
| Dornhorst, A | 1 |
| Inzucchi, SE | 1 |
| Andersen, PH; Jønler, M; Lund, S; Pørksen, N; Schmitz, O | 1 |
| Nelson, G | 1 |
| Fossler, MJ; Haidar, SH; Hussain, AS; Johnson, SB | 1 |
| Kuritzky, L; Quillen, DM | 1 |
| Chowdhury, TA; Lasker, SS | 1 |
| Bragg, A | 1 |
| Koivisto, V | 1 |
| Hu, S | 1 |
| Ahmann, AJ; Riddle, MC | 1 |
| Hatorp, V | 1 |
| Bokvist, K; Gotfredsen, CF; Gromada, J; Hansen, BS; Høy, M; Lindström, P; Olsen, HL; Rorsman, P; Thomsen, MK | 1 |
| Cozma, LS; Dunseath, GJ; Langendorg, KW; Luzio, SD; Owens, DR; Pieber, T | 1 |
| Mafauzy, M | 1 |
| Ashcroft, FM; Carr, RD; Christensen, IT; Hansen, AM; Hansen, JB; Wahl, P | 1 |
| Ashcroft, SJ; Mikhailov, MV; Mikhailova, EA | 1 |
| Furlong, NJ; Hardy, KJ; Hulme, SA; O'Brien, SV | 2 |
| Davies, MJ | 1 |
| Kaku, K; Matsuda, M | 1 |
| Göke, B; Parhofer, KG | 1 |
| Ambrosi, F; Boemi, M; Carle, F; Filipponi, P; Gregorio, F | 1 |
| Dakovska, L; Kirilov, G; Koev, D; Tankova, T | 1 |
| Chassard, D; Evène, E; Jørgensen, M; Nielsen, KK; Thomsen, MS | 1 |
| Lee, IT; Lin, SY; Sheu, WH | 1 |
| Hasslacher, C | 1 |
| Deacon, R; Dunning, BE; Foley, JE; Gutierrez, C; Paladini, S; Valentin, MA | 1 |
| Backman, JT; Neuvonen, M; Neuvonen, PJ; Niemi, M | 1 |
| Birkeland, KI; Bleskestad, IH | 1 |
| Pørksen, N | 1 |
| Bokvist, K; Buschard, K; Gromada, J; Holst, JJ; Høy, M; Krogsgaard Thomsen, M; Lindström, P | 1 |
| Cozma, LS; Luzio, SD; Owens, DR | 1 |
| Vergès, B | 1 |
| Ciccarelli, L; Crescenzi, G; Derosa, G; Fogari, R; Mugellini, A | 2 |
| Bech, P; Gomis, R; Moses, R | 1 |
| Hansen, KT; Hatorp, V; Thomsen, MS | 1 |
| Hale, PM; Hollander, P; Khutoryansky, N; Klaff, L; McGill, J; Raskin, P; South, SA | 1 |
| Kawamura, S; Kobayashi, R; Okada, M; Tachibanaki, S; Takezawa, D; Tokumitsu, H | 1 |
| Bell, CF; Botteman, MF; Braunstein, SN; Devine, ST; Ramsdell, JW; Stephens, JM | 1 |
| Nicklasson, L; Stockl, K; Vanderplas, AM | 1 |
| Bidstrup, TB; Bjørnsdottir, I; Hansen, KT; Sidelmann, UG; Thomsen, MS | 1 |
| Fragoulopoulos, E; Karabina, SP; Katsilambros, N; Kitsou, E; Kolia, M; Kyriaki, D; Perea, D; Sala, C; Tambaki, AP; Tentolouris, N; Tselepis, AD | 1 |
| Backman, JT; Daly, AK; Leathart, JB; Neuvonen, M; Neuvonen, PJ; Niemi, M | 1 |
| Babu, JM; Dubey, PK; Eswaraiah, S; Mathad, VT; Reddy, KV; Reddy, MS; Vyas, K | 1 |
| Blicklé, JF | 1 |
| Yoshida, T; Yoshikawa, T; Yoshioka, K | 1 |
| Baron, MA | 1 |
| Gandhimathi, M; Ravi, TK; Renu, SK | 1 |
| Carr, RD; Degn, KB; Gall, MA; Rizza, RA; Schmitz, O; Thomsen, MK; Veldhuis, JD; Østergård, T | 1 |
| Gooch, B; Greco, S; Hale, PM; Hassman, DR; Jain, R; Jovanovic, L; Khutoryansky, N | 1 |
| Haslbeck, M; Jakob, S; Kellerer, M; Linn, T | 1 |
| Abrahamson, MJ | 1 |
| Backman, JT; Kajosaari, LI; Neuvonen, M; Neuvonen, PJ; Niemi, M | 1 |
| Barbieri, M; Barone, M; Grella, R; Paolisso, G; Passariello, N; Rizzo, MR | 1 |
| Bidstrup, TB; Brøsen, K; Damkier, P; Scharling, B; Stilling, N; Thomsen, MS | 1 |
| Birkeland, KI; Eriksson, J; Hreidarsson, AB; Kjellström, T; Kølendorf, K | 1 |
| Cappleman, JM; Hale, PM; Kaye, W; Khutoryansky, N; McGill, J; Raskin, P; Saad, MF | 1 |
| Figgitt, DP; Plosker, GL | 1 |
| Corll, C; Martin, RJ; Porter, JR; Roane, DS; Zhang, Y; Zhou, J | 1 |
| Brazinsky, SA; Farrell, J; Hale, PM; Hassman, DR; Khutoryansky, N; Madder, RD; Rosenstock, J | 1 |
| Abdel-Salam, OM; Arbid, MS; el-Batran, SA; el-Shenawy, SM; Nofal, SM | 1 |
| Esposito, K; Giugliano, D; Marfella, R; Nappo, F | 1 |
| Alavi, A; Comagic, S; Feilen, P; Höhnemann, S; Piel, M; Rösch, F; Schirrmacher, E; Schirrmacher, R; Schneider, S; Schwanstecher, C; Schwanstecher, M; Shiue, CY; Thews, O; Wängler, B | 1 |
| Leyck Dieken, MG; Pfeiffer, AF; Rochlitz, H; Rudovich, NN | 1 |
| Bae, JH; Cho, CH; Han, J; Jang, BC; Kim, SP; Kim, SS; Lee, HY; Lim, JG; Park, JW; Park, MJ; Song, DK; Suh, SI; Yun, JE | 1 |
| Gall, MA; Lammert, M; Minshall, ME; Nicklasson, L; Palmer, AJ; Roze, S; Spinas, GA; Valentine, WJ | 1 |
| Hofmann, U; Paulwitz, O; Rosak, C | 1 |
| Aldhahi, W; Armstrong, J; Bouche, C; Carr, RD; Goldfine, AB; Moses, A | 1 |
| Backman, JT; Kajosaari, LI; Laitila, J; Neuvonen, M; Neuvonen, PJ | 1 |
| Alavi, A; Beck, C; Feilen, PJ; Rösch, F; Schirrmacher, R; Schneider, S; Schwanstecher, C; Schwanstecher, M; Shiue, CY; Wängler, B | 1 |
| Banerji, MA; Crouse, RJ; Feinglos, MN; Goff, DC; Herrington, DM; Jovanovic, L; Lipkin, EW; Pettitt, DJ; Probstfield, JL; Reboussin, DM; Steffes, M; Summerson, J; Williamson, J | 1 |
| Akbas, SH; Avci, B; Balci, MK; Sari, R | 1 |
| Berney, T; Bosco, D; Carr, RD; Donath, MY; Maedler, K; Zuellig, RA | 1 |
| Garon, J; Gerstein, HC; Joyce, C; Rolfe, A; Walter, CM | 1 |
| Dumitrescu, D; Guja, C; Ioacără, S; Ionescu-Tîrgovişte, C; Tomescu, I | 1 |
| Carrascosa, M; Fernández-Ayala, M; Hernández, JL; Nan, DN | 1 |
| Blackburn, GL | 1 |
| Caumo, A; Cobelli, C; Singhal, P; Taylor, R | 1 |
| Abbatecola, AM; Grella, R; Manzella, D; Paolisso, G | 1 |
| Ashcroft, FM; Carr, RD; Hansen, AM; Hansen, JB; Wahl, P | 1 |
| Adamson, U; Landstedt-Hallin, L; Lins, PE; Nybäck-Nakell, A; von Heijne, M | 1 |
| Abrams, Z; Lieberman, N; Shapiro, MS | 1 |
| Andrade, RJ; Borrás, J; López-García, F; Lucena, MI; Ruiz, JA; Salazar, VR; Sales, J; Verdú, C | 1 |
| Li, JW; Tian, HM; Wang, JN; Yu, HL; Zhang, XX; Zhao, GZ | 1 |
| Bahadduri, P; Chang, C; D'Souza, VM; Ekins, S; Johnston, JS; Ray, A; Swaan, PW | 1 |
| Cozma, LS; Dunseath, GJ; Luzio, SD; Owens, DR; Underwood, PM | 1 |
| Gumieniczek, A | 3 |
| Maaravi, Y; Stessman, J | 1 |
| Backman, JT; Daly, AK; Eichelbaum, M; Kajosaari, LI; Kivistö, KT; Leathart, JB; Neuvonen, M; Neuvonen, PJ; Niemi, M | 1 |
| Bojarska-Junak, A; Gumieniczek, A; Hopkała, H; Roliński, J | 1 |
| Panelo, A; Wing, JR | 1 |
| Agrawal, GP; Awasthi, AM; Jain, NK; Jain, SK | 1 |
| Barbieri, M; Grella, R; Paolisso, G; Passariello, N; Rizzo, MR | 1 |
| Damsbo, P; Gall, MA; Hollingdal, M; Juhl, CB; Pincus, S; Pørksen, N; Schmitz, O; Sturis, J; Veldhuis, JD | 1 |
| Backman, JT; Kajosaari, LI; Laitila, J; Neuvonen, PJ | 1 |
| Backman, JT; Kajosaari, LI; Laitila, J; Neuvonen, M; Neuvonen, PJ; Niemi, M | 1 |
| Jacobson-Dickman, E; Levitsky, L | 1 |
| Bidstrup, TB; Brøsen, K; Damkier, P; Ekblom, M; Karlsson, A; Olsen, AK | 1 |
| Hjemdahl, P; Ostenson, CG; Wallén, NH; Yngen, M | 1 |
| Backman, JT; Jaakkola, T; Kajosaari, LI; Neuvonen, PJ | 1 |
| Horie, T; Shitara, Y; Sugiyama, Y | 1 |
| Gao, LM; Song, DQ; Yang, P | 1 |
| Choudhury, H; Harisudhan, T; Mullangi, R; Srinivas, NR; Venkatesh, P | 1 |
| Backman, JT; Kajosaari, LI; Neuvonen, PJ; Niemi, M | 2 |
| Gabelica, V; Mandić, Z | 1 |
| Dolff, S; Heemann, U; Janssen, OE; Kribben, A; Mann, K; Philipp, T; Pietruck, F; Türk, T; Witzke, O | 1 |
| Schmoelzer, I; Wascher, TC | 1 |
| Anwar, A; Azmi, KN; Hamidon, BB; Khalid, BA | 1 |
| Marshall, V; Shakir, S; Wilton, L | 1 |
| Agrawal, GP; Jain, NK; Jain, SK | 2 |
| Bayram, F; Cesur, M; Corapcioglu, D; Emral, R; Gonen, S; Gursoy, A; Kamel, N; Ozduman, M; Tonyukuk, V; Uysal, AR; Yilmaz, AE | 1 |
| Kühner, P; Quast, U; Russ, U; Stephan, D; Winkler, M | 1 |
| Türk, T; Witzke, O | 1 |
| Fedele, V; Fioravanti, M; Leotta, C; Paolisso, G; Papa, G; Purrello, F; Rizzo, MR; Solerte, SB | 1 |
| Ciampa, F; Colatrella, A; Fallucca, F; Napoli, A | 1 |
| Erkent, U; Ertunc, M; Guc, MO; Ilhan, M; Iskit, AB; Onur, R | 1 |
| Betti, RT; Ferreira, BM; Gersh, BJ; Hueb, W; Lopes, N; Moffa, PJ; Ramires, JA; Uchida, AH; Wajchenberg, BL | 1 |
| Diaz-Garcia, C; Martin-Cortes, A; Mollar-Puchades, MA; Perez-Calvo, A | 1 |
| Cetinkalp, S; Erdogan, M; Karadeniz, M; Ozbek, M; Ozgen, AG; Saygili, F; Tuzun, M; Yilmaz, C | 1 |
| Gan, SH; Imran, A; Ismail, Z; Ruzilawati, AB; Wahab, MS | 1 |
| Grill, V; Kollind, M; Qvigstad, E; Radtke, M | 1 |
| Frandsen, M; Lund, SS; Parving, HH; Pedersen, O; Schalkwijk, CG; Smidt, UM; Stehouwer, CD; Tarnow, L; Vaag, A | 1 |
| Davies, MJ; Howe, J; Jarvis, J; Johnston, V; Kitchener, DL; Lawrence, IG; McNally, PG; Skinner, TC; Thaware, PK; Tringham, JR | 1 |
| Jin, SH; Li, ZR; Shi, YQ; Yao, J | 1 |
| Black, C; Donnelly, P; McIntyre, L; Royle, PL; Shepherd, JP; Thomas, S | 1 |
| Krentz, AJ | 1 |
| Bieger, S; Kühner, P; Quast, U; Stephan, D; Winkler, M; Wolff, F | 1 |
| Huang, L; Li, J; Li, Q; Li, Y; Liang, J; Liu, Y; Luo, R; Ni, Z; Tian, H; Wang, N; Wu, T; Yu, H | 1 |
| Civera, M; Martínez, I; Merchante, A; Salvador, M; Sanz, J | 1 |
| Crisp, MT; Johnston, KP; Mattucci, ME; Purvis, T; Williams, RO | 1 |
| Backman, JT; Ingelman-Sundberg, M; Kajosaari, LI; Neuvonen, PJ; Niemi, M; Robledo, M; Rodríguez-Antona, C | 1 |
| Birkeland, KI; Johansen, OE | 1 |
| Frandsen, M; Lund, SS; Parving, HH; Pedersen, O; Smidt, UM; Tarnow, L; Vaag, AA | 1 |
| Attia, AK; El-Ries, MA; Mohamed, GG | 1 |
| Alagona, C; Chiavetta, A; Fedele, V; Leotta, C; Lorenti, I; Luca, S; Papa, G; Pezzino, V; Piro, S; Purrello, F; Rabuazzo, AM; Spadaro, L | 1 |
| Kalliokoski, A; Neuvonen, M; Neuvonen, PJ; Niemi, M | 2 |
| Gupta, A; Jain, S; Kumar, N; Tiwary, AK | 1 |
| Kapoor, JR | 1 |
| Bachmakov, I; Fromm, MF; Glaeser, H; König, J | 1 |
| Backman, JT; Kalliokoski, A; Laitila, J; Neuvonen, M; Neuvonen, PJ; Niemi, M; Tornio, A | 1 |
| Akeson, J; Belknap, SM; Brooks, I; Deitrick, DL; Getz, M; Lanzotti, SA; Maurer, T; Moore, H; Peterson, A; Soltysik, RC; Storm, GA; Yarnold, PR | 1 |
| Moses, RG | 1 |
| Frandsen, M; Gram, J; Lund, SS; Parving, HH; Pedersen, O; Schalkwijk, CG; Smidt, UM; Stehouwer, CD; Tarnow, L; Teerlink, T; Vaag, AA; Winther, K | 1 |
| Khamaisi, M; Leitersdorf, E | 1 |
| Raskin, P | 1 |
| Bao, YQ; He, YY; Hu, C; Jia, WP; Lu, JX; Shao, XY; Wang, CR; Xiang, KS; Zhang, R | 1 |
| Chu, PL; Hoelscher, D; Lyness, W | 1 |
| Arnqvist, HJ; Chisalita, SI; Eson Jennersjö, P; Lindström, T; Olsson, AG; Paulsson, JF; Westermark, GT | 1 |
| Bakiner, O; Bozkirli, E; Demirag, NG; Ertorer, ME; Tutuncu, NB | 1 |
| Kanojia, M; Seedher, N | 1 |
| Backman, JT; Kalliokoski, A; Neuvonen, PJ; Niemi, M | 1 |
| Li, C; Wang, L; Wang, S; Xia, J; Zhang, G | 1 |
| Cicero, AF; D'Angelo, A; Derosa, G; Ferrari, I; Maffioli, P; Mereu, R; Palumbo, I; Randazzo, S; Salvadeo, SA | 1 |
| Backman, JT; Kalliokoski, A; Kurkinen, KJ; Neuvonen, PJ; Niemi, M | 1 |
| Duran, C; Ercan, I; Ersoy, C; Erturk, E; Guclu, M; Imamoglu, S; Kiyici, S; Selimoglu, H; Tuncel, E | 1 |
| Cornelius, V; Kasliwal, R; Shakir, SA; Vlckova, V; Wilton, L | 1 |
| Lewin, A; Lyness, W; Raskin, P; Reinhardt, R | 2 |
| Jankovec, Z; Lacigova, S | 1 |
| Antic, S; Dimic, D; Radenkovic, S; Velojic Golubovic, M | 1 |
| Davis, SN | 1 |
| Bao, Y; Jia, W; Qiu, Y; Su, M; Wang, X; Zhao, T | 1 |
| Fasano, CJ; Rowden, AK | 1 |
| Backman, JT; Honkalammi, J; Kurkinen, KJ; Neuvonen, M; Neuvonen, PJ; Niemi, M; Tornio, A | 1 |
| Gumieniczek, A; Krzywdzińska, M; Nowak, M | 1 |
| Frandsen, M; Hansen, BV; Lund, SS; Nielsen, BB; Parving, HH; Pedersen, O; Tarnow, L; Vaag, AA | 1 |
| Anwar, S; Baral, C; Hakenberg, J; Liang, S; Tari, L | 1 |
| Maren, K; Rojkjaer, L; Skerjanec, A; Wang, J | 1 |
| Jain, A; Mishra, A; Muthu, MS; Rawat, MK; Singh, S | 2 |
| Chen, X; Gong, ZC; Huang, Q; Liu, ZQ; Ren, HY; Sheng, FF; Wu, J; Xu, XJ; Yin, JY; Yu, M; Zhou, HH | 1 |
| Cheng, H; Fu, Z; Li, Y; Ran, J; Shen, J; Wang, M; Xu, L; Yan, L; Zhang, Y | 1 |
| Aoyagi, K; Nagamatsu, S; Nakamichi, Y; Nishiwaki, C; Ohara-Imaizumi, M | 1 |
| Möhlig, M; Otto, B; Pfeiffer, AF; Pivovarova, O; Rudovich, N; Spranger, J; Weickert, MO | 1 |
| Longo, R | 1 |
| Gan, SH; Mohd Suhaimi, AW; Ruzilawati, AB | 1 |
| Blondel, E; Fonrose, X; Mallaret, MP; Roustit, M; Villier, C | 1 |
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| Azadbakht, M; Cheraghbaeigi, S; Kalehoei, E; Moradi, M; Parvini, M; Saghari, S; Zhaleh, H | 1 |
| Abdollahi, M; Asgarian, S; Baeeri, M; Dehpour, AR; Emamgholipour, Z; Firoozpour, L; Foroumadi, A; Foroumadi, R; Gholami, M; Goli, F; Keykhaei, M | 1 |
83 review(s) available for carbamates and repaglinide
| Article | Year |
|---|---|
Modulation of insulin secretion in non-insulin-dependent diabetes mellitus by two novel oral hypoglycaemic agents, NN623 and A4166.
Topics: Administration, Oral; Biological Availability; Blood Glucose; Carbamates; Cyclohexanes; Diabetes Mellitus, Type 2; Glyburide; Humans; Hypoglycemic Agents; Insulin; Insulin Secretion; Intestinal Absorption; Molecular Structure; Nateglinide; Phenylalanine; Piperidines; Reference Values; Stereoisomerism | 1996 |
[Repaglinide (NN-623)].
Topics: Animals; Blood Glucose; Carbamates; Clinical Trials, Phase II as Topic; Diabetes Mellitus, Type 2; Glycated Hemoglobin; Humans; Hypoglycemic Agents; Insulin; Insulin Secretion; Islets of Langerhans; Piperidines; Protein Precursors | 1997 |
Repaglinide.
Topics: Animals; Carbamates; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Glyburide; Humans; Hypoglycemic Agents; Islets of Langerhans; Piperidines; Randomized Controlled Trials as Topic; Stereoisomerism | 1998 |
Type 2 diabetes: glycemic targets and oral therapies for older patients.
Topics: 1-Deoxynojirimycin; Acarbose; Age Factors; Aged; Blood Glucose; Carbamates; Diabetes Mellitus, Type 2; Glucosamine; Humans; Hypoglycemic Agents; Imino Pyranoses; Metformin; Piperidines; Sulfonylurea Compounds; Trisaccharides | 1998 |
Management of antidiabetic medications in overdose.
Topics: Carbamates; Drug Overdose; Glucose; Humans; Hypoglycemic Agents; Insulin; Piperidines; Sulfonylurea Compounds | 1998 |
Repaglinide--prandial glucose regulator: a new class of oral antidiabetic drugs.
Topics: Administration, Oral; Animals; Blood Glucose; Carbamates; Clinical Trials as Topic; Diabetes Mellitus, Type 2; Eating; Fasting; Humans; Hypoglycemic Agents; Metabolic Clearance Rate; Piperidines; Postprandial Period | 1998 |
The elderly Type 2 diabetic patient: special considerations.
Topics: Aged; Amyloid; Blood Glucose; Carbamates; Cognition Disorders; Depression; Diabetes Mellitus, Type 2; Female; Humans; Hypoglycemic Agents; Insulin Resistance; Islet Amyloid Polypeptide; Male; Piperidines | 1998 |
Drug therapy of postprandial hyperglycaemia.
Topics: 1-Deoxynojirimycin; Acarbose; Amyloid; Carbamates; Diabetes Mellitus; Enzyme Inhibitors; Glucosamine; Glyburide; Humans; Hyperglycemia; Hypoglycemic Agents; Imino Pyranoses; Inositol; Insulin; Insulin Lispro; Islet Amyloid Polypeptide; Piperidines; Postprandial Period; Trisaccharides | 1999 |
Repaglinide, a new oral antidiabetic agent: a review of recent preclinical studies.
Topics: Administration, Oral; Animals; Carbamates; Diabetes Mellitus, Type 2; Hypoglycemic Agents; Piperidines; Rats | 1999 |
Repaglinide: a new short-acting insulinotropic agent for the treatment of type 2 diabetes.
Topics: Carbamates; Diabetes Mellitus, Type 2; Humans; Hypoglycemic Agents; Insulin; Insulin Secretion; Piperidines | 1999 |
Pharmacologic therapy for type 2 diabetes mellitus.
Topics: Acarbose; Administration, Oral; Algorithms; Carbamates; Chromans; Diabetes Mellitus, Type 2; Evidence-Based Medicine; Humans; Hypoglycemic Agents; Insulin; Metformin; Piperidines; Sulfonylurea Compounds; Thiazoles; Thiazolidinediones; Trisaccharides; Troglitazone | 1999 |
Repaglinide as monotherapy in Type 2 diabetes.
Topics: Blood Glucose; Carbamates; Controlled Clinical Trials as Topic; Diabetes Mellitus, Type 2; Food; Glycated Hemoglobin; Humans; Hypoglycemic Agents; Piperidines | 1999 |
Mechanism of action of a new class of insulin secretagogues.
Topics: Animals; Blood Glucose; Calcium; Carbamates; Electric Conductivity; Humans; Hypoglycemic Agents; Insulin; Insulin Secretion; Piperidines; Potassium; Rats | 1999 |
Preclinical and clinical studies on safety and tolerability of repaglinide.
Topics: Aged; Animals; Carbamates; Diabetes Mellitus, Type 2; Humans; Hypoglycemia; Hypoglycemic Agents; Piperidines; Randomized Controlled Trials as Topic | 1999 |
The use of insulin secretagogues in the treatment of type 2 diabetes.
Topics: Acarbose; Carbamates; Chromans; Diabetes Mellitus, Type 2; Drug Therapy, Combination; Glucagon; Glucagon-Like Peptide 1; Humans; Hypoglycemic Agents; Metformin; Peptide Fragments; Piperidines; Protein Precursors; Risk Factors; Sulfonylurea Compounds; Thiazoles; Thiazolidinediones; Troglitazone | 1999 |
New drugs for diabetes.
Topics: Carbamates; Chromans; Cyclohexanes; Diabetes Mellitus, Type 2; Humans; Hypoglycemic Agents; Insulin Resistance; Metformin; Nateglinide; Phenylalanine; Piperidines; Thiazoles; Thiazolidinediones; Troglitazone | 1999 |
Repaglinide--a new compound for the treatment of patients with type 2 diabetes.
Topics: Administration, Oral; Blood Glucose; Carbamates; Diabetes Mellitus, Type 2; Feeding Behavior; Humans; Hypoglycemia; Hypoglycemic Agents; Intestinal Absorption; Metabolic Clearance Rate; Piperidines | 1999 |
New directions in type 2 diabetes mellitus: an update of current oral antidiabetic therapy.
Topics: Carbamates; Chromans; Diabetes Mellitus, Type 2; Humans; Hypoglycemic Agents; Metformin; Piperidines; Sulfonylurea Compounds; Thiazoles; Thiazolidinediones; Troglitazone | 1999 |
New agents for Type 2 diabetes.
Topics: Anti-Obesity Agents; Carbamates; Chromans; Diabetes Mellitus, Type 2; Drug Design; Humans; Hypoglycemic Agents; Insulin Resistance; Piperidines; Sulfonylurea Compounds; Thiazoles; Thiazolidinediones; Troglitazone | 1999 |
Combining sulfonylureas and other oral agents.
Topics: Acarbose; Administration, Oral; Carbamates; Diabetes Mellitus, Type 2; Dose-Response Relationship, Drug; Drug Therapy, Combination; Glyburide; Humans; Hypoglycemic Agents; Metformin; Piperidines; Sulfonylurea Compounds | 2000 |
Clinical efficacy of new thiazolidinediones and glinides in the treatment of type 2 diabetes mellitus.
Topics: Carbamates; Cyclohexanes; Diabetes Mellitus, Type 2; Drug Therapy, Combination; Glycated Hemoglobin; Humans; Hypoglycemic Agents; Nateglinide; Phenylalanine; Pioglitazone; Piperidines; Rosiglitazone; Thiazoles; Thiazolidinediones | 2000 |
Pharmacology and clinical experience with repaglinide.
Topics: Animals; Carbamates; Clinical Trials as Topic; Diabetes Mellitus, Type 2; Eating; Humans; Hypoglycemic Agents; Piperidines | 2000 |
Review of prandial glucose regulation with repaglinide: a solution to the problem of hypoglycaemia in the treatment of Type 2 diabetes?
Topics: Blood Glucose; Carbamates; Diabetes Mellitus, Type 2; Drug Therapy, Combination; Eating; Humans; Hypoglycemia; Hypoglycemic Agents; Insulin; Insulin Secretion; Patient Compliance; Piperidines; Risk Factors; Sulfonylurea Compounds; Time Factors | 2000 |
The importance of early insulin secretion and its impact on glycaemic regulation.
Topics: Blood Glucose; Carbamates; Diabetes Mellitus, Type 2; Drug Therapy, Combination; Eating; Humans; Hyperglycemia; Hypoglycemic Agents; Insulin; Insulin Resistance; Insulin Secretion; Piperidines; Time Factors | 2000 |
Recent advances in the pharmacologic management of diabetes mellitus.
Topics: Acarbose; Administration, Oral; Carbamates; Chromans; Diabetes Mellitus; Drug Overdose; Emergencies; Humans; Hypoglycemic Agents; Insulin; Insulin Lispro; Metformin; Piperidines; Sulfonylurea Compounds; Thiazoles; Thiazolidinediones; Troglitazone | 2000 |
Meglitinide analogues in the treatment of type 2 diabetes mellitus.
Topics: Benzamides; Carbamates; Cyclohexanes; Diabetes Mellitus, Type 2; Glyburide; Humans; Hypoglycemic Agents; Molecular Structure; Nateglinide; Phenylalanine; Piperidines | 2000 |
Repaglinide: prandial glucose regulation in clinical practice.
Topics: Carbamates; Drug Therapy, Combination; Humans; Hyperglycemia; Hypoglycemic Agents; Piperidines; Postprandial Period; Safety; Time Factors; Treatment Outcome | 2000 |
Current understanding regarding the role of repaglinide in post-prandial hyperglycemia.
Topics: Carbamates; Humans; Hyperglycemia; Hypoglycemic Agents; Piperidines; Postprandial Period; Treatment Outcome | 2001 |
The role of prandial glucose regulation with repaglinide in addressing the problem of hypoglycemia in the treatment of type 2 diabetes.
Topics: Carbamates; Diabetes Mellitus, Type 2; Humans; Hypoglycemia; Hypoglycemic Agents; Patient Compliance; Piperidines; Postprandial Period; Randomized Controlled Trials as Topic | 2001 |
Combination therapy in type 2 diabetes: the role of repaglinide.
Topics: Carbamates; Chromans; Diabetes Mellitus, Type 2; Drug Synergism; Drug Therapy, Combination; Humans; Hypoglycemic Agents; Insulin, Isophane; Metformin; Piperidines; Thiazoles; Thiazolidinediones; Troglitazone | 2001 |
A review of clinical experience with the prandial glucose regulator, repaglinide, in the treatment of type 2 diabetes.
Topics: Blood Glucose; Carbamates; Clinical Trials as Topic; Diabetes Mellitus, Type 2; Drug Therapy, Combination; Humans; Hypoglycemic Agents; Piperidines; Postprandial Period | 2000 |
Rapid acting insulinotropic agents: restoration of early insulin secretion as a physiologic approach to improve glucose control.
Topics: Animals; Carbamates; Cyclohexanes; Diabetes Mellitus, Type 2; Glucose; Guanidines; Humans; Hypoglycemic Agents; Indoles; Insulin; Insulin Secretion; Isoindoles; Nateglinide; Phenylalanine; Piperidines | 2001 |
[Repaglinide, potentially a therapeutic improvement for diabetes mellitus type 2].
Topics: Carbamates; Diabetes Mellitus, Type 2; Drug Therapy, Combination; Glyburide; Humans; Hypoglycemia; Hypoglycemic Agents; Insulin; Insulin Secretion; Metformin; Piperidines; Therapeutic Equivalency | 2001 |
[Objectives and therapeutic strategy in type 2 diabetes mellitus].
Topics: Carbamates; Diabetes Mellitus, Type 2; Diabetic Angiopathies; Humans; Hyperinsulinism; Hypoglycemic Agents; Insulin Resistance; Piperidines; Thiazoles | 2001 |
Repaglinide: a review of its therapeutic use in type 2 diabetes mellitus.
Topics: Administration, Oral; Adult; Aged; Aging; Animals; Biological Availability; Blood Glucose; Carbamates; Clinical Trials as Topic; Diabetes Mellitus, Type 2; Dose-Response Relationship, Drug; Drug Interactions; Glycated Hemoglobin; Half-Life; Humans; Hypoglycemic Agents; Intestinal Absorption; Metabolic Clearance Rate; Piperidines | 2001 |
[New drugs].
Topics: Amdinocillin; Carbamates; Clopidogrel; Cyclohexanes; Drug Interactions; Humans; Hypoglycemic Agents; Nateglinide; Patient Selection; Penicillins; Phenylalanine; Piperidines; Platelet Aggregation Inhibitors; Pneumococcal Vaccines; Raloxifene Hydrochloride; Safety; Selective Estrogen Receptor Modulators; Ticlopidine | 2001 |
[News in oral antidiabetic therapy].
Topics: Administration, Oral; Carbamates; Diabetes Mellitus; Humans; Hypoglycemic Agents; Pioglitazone; Piperidines; Rosiglitazone; Thiazoles; Thiazolidinediones | 2001 |
Insulinotropic meglitinide analogues.
Topics: Adult; Animals; Benzamides; Carbamates; Cyclohexanes; Diabetes Mellitus, Type 2; Humans; Hypoglycemic Agents; Insulin; Insulin Secretion; Nateglinide; Phenylalanine; Piperidines; Rats | 2001 |
Oral antihyperglycemic therapy for type 2 diabetes: scientific review.
Topics: Administration, Oral; Biguanides; Blood Glucose; Carbamates; Chromans; Diabetes Mellitus, Type 2; Diet; Drug Therapy, Combination; Enzyme Inhibitors; Exercise; Glycated Hemoglobin; Glycoside Hydrolase Inhibitors; Humans; Hypoglycemic Agents; Metformin; Piperidines; Randomized Controlled Trials as Topic; Sulfonylurea Compounds; Thiazoles; Thiazolidinediones; Troglitazone | 2002 |
Type 2 diabetes management: a comprehensive clinical review of oral medications.
Topics: Benzamides; Carbamates; Diabetes Mellitus, Type 2; Drug Therapy, Combination; Glycoside Hydrolase Inhibitors; Humans; Hypoglycemic Agents; Metformin; Piperidines; Sulfonylurea Compounds; Thiazoles; Thiazolidinediones | 2002 |
[Insulin analogs and new oral antidiabetic drugs].
Topics: Administration, Oral; Carbamates; Cyclohexanes; Diabetes Mellitus; Dose-Response Relationship, Drug; Glucose; Humans; Hypoglycemic Agents; Insulin; Insulin Secretion; Nateglinide; Phenylalanine; Piperidines; Receptors, Cytoplasmic and Nuclear; Thiazoles; Thiazolidinediones; Transcription Factors | 1999 |
Current oral agents for type 2 diabetes. Many options, but which to choose when?
Topics: Carbamates; Cyclohexanes; Diabetes Mellitus, Type 2; Drug Monitoring; Drug Therapy, Combination; Glycoside Hydrolases; Humans; Hypoglycemic Agents; Metformin; Nateglinide; Phenylalanine; Piperidines; Receptors, Cytoplasmic and Nuclear; Sulfonylurea Compounds; Transcription Factors | 2002 |
Clinical pharmacokinetics and pharmacodynamics of repaglinide.
Topics: Adult; Aged; Blood Glucose; Carbamates; Clinical Trials as Topic; Diabetes Mellitus, Type 2; Dose-Response Relationship, Drug; Drug Interactions; Female; Humans; Hypoglycemic Agents; Liver Diseases; Male; Piperidines; Renal Insufficiency; Rifampin | 2002 |
Insulin secretagogues.
Topics: Carbamates; Cyclohexanes; Diabetes Mellitus, Type 2; Glycated Hemoglobin; Humans; Hyperglycemia; Hyperinsulinism; Hypoglycemic Agents; Insulin; Insulin Secretion; Islets of Langerhans; Nateglinide; Phenylalanine; Piperidines; Postprandial Period; Sulfonylurea Compounds; United Kingdom | 2002 |
[Structures and mechanisms for non SU insulin secretagogues].
Topics: Adenosine Triphosphate; Animals; ATP-Binding Cassette Transporters; Calcium Channels; Carbamates; Cyclohexanes; Exocytosis; Humans; Hypoglycemic Agents; Indoles; Insulin; Insulin Secretion; Islets of Langerhans; Isoindoles; Nateglinide; Organ Specificity; Phenylalanine; Piperidines; Potassium Channels; Potassium Channels, Inwardly Rectifying; Receptors, Drug; Sulfonylurea Receptors | 2002 |
[Repaglinide (NN-623)].
Topics: Adenosine Triphosphate; Administration, Oral; Calcium Channels; Carbamates; Clinical Trials as Topic; Diabetes Mellitus, Type 2; Humans; Hypoglycemic Agents; Insulin; Insulin Secretion; Islets of Langerhans; Piperidines; Potassium Channels | 2002 |
Early changes in beta-cell function and insulin pulsatility as predictors for type 2 diabetes.
Topics: Carbamates; Circadian Rhythm; Diabetes Mellitus, Type 2; Humans; Hypoglycemic Agents; Insulin; Insulin Resistance; Insulin Secretion; Islets of Langerhans; Pancreas; Piperidines; Predictive Value of Tests; Pulsatile Flow | 2002 |
Early-phase prandial insulin secretion: its role in the pathogenesis of type 2 diabetes mellitus and its modulation by repaglinide.
Topics: Area Under Curve; Blood Glucose; Carbamates; Diabetes Mellitus, Type 2; Glucose; Humans; Hyperglycemia; Hypoglycemic Agents; Insulin; Insulin Secretion; Kinetics; Liver; Piperidines | 2002 |
The impact of prandial glucose regulation in practice.
Topics: Blood Glucose; Carbamates; Diabetes Mellitus, Type 2; Glycated Hemoglobin; Humans; Hyperglycemia; Hypoglycemic Agents; Patient Compliance; Piperidines; Postprandial Period; Quality of Life | 2002 |
Repaglinide in combination therapy.
Topics: Carbamates; Chromans; Diabetes Mellitus, Type 2; Drug Therapy, Combination; Humans; Hypoglycemic Agents; Insulin; Metformin; Pioglitazone; Piperidines; Postprandial Period; Rosiglitazone; Thiazoles; Thiazolidinediones; Treatment Outcome; Troglitazone | 2002 |
[symbol: see text] Nateglinide and [symbol: see text] repaglinide for type 2 diabetes?
Topics: Carbamates; Cyclohexanes; Diabetes Mellitus, Type 2; Double-Blind Method; Humans; Hypoglycemic Agents; Nateglinide; Phenylalanine; Piperidines; Randomized Controlled Trials as Topic; Treatment Outcome | 2003 |
[Continuation 50. Type 2 diabetes: possibilities and limitations of pharmacological therapy].
Topics: 1-Deoxynojirimycin; Acarbose; Aged; Blood Glucose; Carbamates; Contraindications; Cyclohexanes; Diabetes Mellitus, Type 2; Drug Therapy, Combination; Enzyme Inhibitors; Fasting; Follow-Up Studies; Germany; Glucosamine; Glyburide; Glycated Hemoglobin; Glycoside Hydrolase Inhibitors; Humans; Hypoglycemia; Hypoglycemic Agents; Imino Pyranoses; Insulin; Metformin; Middle Aged; Nateglinide; Obesity; Patient Compliance; Phenylalanine; Pioglitazone; Piperidines; Practice Guidelines as Topic; Risk Factors; Rosiglitazone; Sulfonylurea Compounds; Thiazolidinediones; Time Factors | 2003 |
Repaglinide : a pharmacoeconomic review of its use in type 2 diabetes mellitus.
Topics: Administration, Oral; Carbamates; Clinical Trials as Topic; Cost of Illness; Cost-Benefit Analysis; Diabetes Mellitus, Type 2; Drug Interactions; Economics, Pharmaceutical; Humans; Hypoglycemic Agents; Piperidines; Quality of Life; Randomized Controlled Trials as Topic | 2004 |
Pharmacology of the meglitinide analogs: new treatment options for type 2 diabetes mellitus.
Topics: Animals; Benzamides; Carbamates; Cyclohexanes; Diabetes Mellitus, Type 2; Humans; Hypoglycemic Agents; Nateglinide; Phenylalanine; Piperidines | 2003 |
Transporters as a determinant of drug clearance and tissue distribution.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Bile; Carbamates; Cell Line; Drug Interactions; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypoglycemic Agents; Kidney; Liver; Membrane Transport Proteins; Metabolic Clearance Rate; Metformin; Organic Anion Transporters; Organic Cation Transport Proteins; Piperidines; Polymorphism, Genetic; Species Specificity; Tissue Distribution; Transfection | 2006 |
Drug-drug and food-drug pharmacokinetic interactions with new insulinotropic agents repaglinide and nateglinide.
Topics: Anti-Bacterial Agents; Area Under Curve; Biological Availability; Biotransformation; Carbamates; Cyclohexanes; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Drug Administration Schedule; Drug Interactions; Enzyme Induction; Enzyme Inhibitors; Fasting; Food-Drug Interactions; Humans; Hypoglycemic Agents; Intestinal Absorption; Nateglinide; Phenylalanine; Piperidines; Postprandial Period | 2007 |
Meglitinide analogues for type 2 diabetes mellitus.
Topics: Benzamides; Carbamates; Cyclohexanes; Diabetes Mellitus, Type 2; Humans; Hypoglycemic Agents; Metformin; Nateglinide; Phenylalanine; Piperidines; Randomized Controlled Trials as Topic | 2007 |
New oral agents for type 2 diabetes.
Topics: Acarbose; Carbamates; Chromans; Diabetes Mellitus, Type 2; Humans; Hypoglycemic Agents; Pioglitazone; Piperidines; Pyrazoles; Rimonabant; Thiazolidinediones; Troglitazone | 2007 |
Defining the role of repaglinide in the management of type 2 diabetes mellitus: a review.
Topics: Carbamates; Clinical Trials as Topic; Diabetes Mellitus, Type 2; Drug-Related Side Effects and Adverse Reactions; Humans; Hypoglycemic Agents; Piperidines | 2007 |
Oral combination therapy: repaglinide plus metformin for treatment of type 2 diabetes.
Topics: Administration, Oral; Blood Glucose; Carbamates; Diabetes Mellitus, Type 2; Drug Therapy, Combination; Humans; Hypoglycemic Agents; Insulin; Metformin; Piperidines; Treatment Outcome; Weight Gain | 2008 |
Drugs for type 2 diabetes.
Topics: alpha-Galactosidase; Biguanides; Carbamates; Cyclohexanes; Diabetes Mellitus, Type 2; Drug Combinations; Drug Therapy, Combination; Humans; Hypoglycemic Agents; Insulin; Nateglinide; Phenylalanine; Piperidines; Pyrazines; Sitagliptin Phosphate; Sulfonylurea Compounds; Thiazolidinediones; Triazoles | 2008 |
Nateglinide versus repaglinide for type 2 diabetes mellitus in China.
Topics: Carbamates; China; Cyclohexanes; Diabetes Mellitus, Type 2; Female; Glycated Hemoglobin; Humans; Hypoglycemic Agents; Male; Middle Aged; Nateglinide; Phenylalanine; Piperidines | 2009 |
Advances in oral therapy for type 2 diabetes.
Topics: Acarbose; Administration, Oral; Blood Glucose; Carbamates; Cyclohexanes; Diabetes Mellitus, Type 2; Drug Combinations; Drug Therapy, Combination; Glycated Hemoglobin; Humans; Hypoglycemia; Hypoglycemic Agents; Insulin; Insulin Secretion; Insulin-Secreting Cells; Metformin; Nateglinide; Phenylalanine; Piperidines; Randomized Controlled Trials as Topic; Thiazolidinediones; United States; Weight Gain | 2000 |
Development of repaglinide loaded solid lipid nanocarrier: selection of fabrication method.
Topics: Biological Availability; Calorimetry, Differential Scanning; Carbamates; Drug Carriers; Hypoglycemic Agents; Lipids; Microscopy, Electron, Transmission; Nanostructures; Particle Size; Piperidines | 2010 |
The nasty surprise of a complex drug-drug interaction.
Topics: Carbamates; Drug Approval; Drug Evaluation, Preclinical; Drug Industry; Drug Interactions; Drug Therapy, Combination; Gemfibrozil; Humans; Itraconazole; Models, Biological; Piperidines | 2010 |
SLCO1B1 polymorphism and oral antidiabetic drugs.
Topics: Administration, Oral; Alleles; Carbamates; Cyclohexanes; Genotype; Haplotypes; Humans; Hypoglycemic Agents; Liver-Specific Organic Anion Transporter 1; Nateglinide; Organic Anion Transporters; Phenylalanine; Pioglitazone; Piperidines; Polymorphism, Genetic; Rosiglitazone; Thiazolidinediones | 2010 |
Variations in tissue selectivity amongst insulin secretagogues: a systematic review.
Topics: Animals; ATP-Binding Cassette Transporters; Carbamates; Cardiovascular Diseases; Cricetinae; Cyclohexanes; Diabetes Mellitus, Type 2; Gliclazide; Glipizide; Glyburide; Humans; Hypoglycemic Agents; Ischemic Preconditioning, Myocardial; Isoindoles; Mice; Muscle, Smooth, Vascular; Myocytes, Cardiac; Nateglinide; Phenylalanine; Piperidines; Potassium Channels, Inwardly Rectifying; Rats; Receptors, Drug; Risk Factors; Sulfonylurea Compounds; Sulfonylurea Receptors; Tolbutamide | 2012 |
[Genetic polymorphisms of SLCO1B1 for drug pharmacokinetics and its clinical implications].
Topics: Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Antineoplastic Agents, Phytogenic; Camptothecin; Carbamates; Haplotypes; Hepatocytes; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypoglycemic Agents; Irinotecan; Liver; Liver-Specific Organic Anion Transporter 1; Organic Anion Transporters; Pharmacogenetics; Piperidines; Polymorphism, Genetic | 2011 |
Repaglinide: a review of its use in type 2 diabetes mellitus.
Topics: Carbamates; Diabetes Mellitus, Type 2; Humans; Hypoglycemic Agents; Piperidines; Randomized Controlled Trials as Topic | 2012 |
Severe hypoglycaemia from repaglinide-brotizolam drug interaction: a case report and literature review.
Topics: Aged; Azepines; Blood Glucose; Carbamates; Diabetes Mellitus, Type 2; Drug Interactions; Humans; Hypnotics and Sedatives; Hypoglycemia; Hypoglycemic Agents; Male; Piperidines; Sleep Wake Disorders | 2012 |
CYP2C metabolism of oral antidiabetic drugs--impact on pharmacokinetics, drug interactions and pharmacogenetic aspects.
Topics: Administration, Oral; Benzamides; Blood Glucose; Carbamates; Cytochrome P-450 Enzyme System; Drug Interactions; Gemfibrozil; Humans; Hypoglycemic Agents; Inactivation, Metabolic; Pharmacogenetics; Piperidines; Polymorphism, Single Nucleotide; Sulfonylurea Compounds; Thiazolidinediones | 2012 |
Options for combination therapy in type 2 diabetes: comparison of the ADA/EASD position statement and AACE/ACE algorithm.
Topics: Algorithms; Carbamates; Diabetes Mellitus, Type 2; Dipeptidyl-Peptidase IV Inhibitors; Drug Therapy, Combination; Exenatide; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Humans; Hypoglycemic Agents; Incretins; Insulin; Liraglutide; Metformin; Peptides; Piperidines; Practice Guidelines as Topic; Receptors, Glucagon; Sulfonylurea Compounds; Thiazolidinediones; Venoms | 2013 |
The pharmacogenetics of type 2 diabetes: a systematic review.
Topics: Acarbose; Biomarkers, Pharmacological; Blood Glucose; Carbamates; Diabetes Mellitus, Type 2; Humans; Hypoglycemic Agents; Metformin; Pharmacogenetics; Pioglitazone; Piperidines; Polymorphism, Genetic; Prediabetic State; Rosiglitazone; Sulfonylurea Compounds; Thiazolidinediones | 2014 |
Comparison of repaglinide and metformin versus metformin alone for type 2 diabetes: a meta-analysis of randomized controlled trials.
Topics: Carbamates; Diabetes Mellitus, Type 2; Drug Therapy, Combination; Glycated Hemoglobin; Humans; Hypoglycemic Agents; Metformin; Piperidines | 2014 |
Pharmacogenomics of glinides.
Topics: Carbamates; Cyclohexanes; Diabetes Mellitus, Type 2; Humans; Hypoglycemic Agents; Inactivation, Metabolic; Insulin; Insulin Secretion; Insulin-Secreting Cells; Isoindoles; KATP Channels; Nateglinide; Pharmacogenetics; Phenylalanine; Piperidines | 2015 |
Impact of glucose-lowering drugs on cardiovascular disease in type 2 diabetes.
Topics: Carbamates; Clinical Trials as Topic; Coronary Artery Disease; Cyclohexanes; Diabetes Mellitus, Type 2; Diabetic Angiopathies; Dipeptidyl-Peptidase IV Inhibitors; Glucagon-Like Peptide-1 Receptor; Glycoside Hydrolase Inhibitors; Humans; Hypoglycemic Agents; Insulin; Metformin; Nateglinide; Phenylalanine; Piperidines; Sodium-Glucose Transport Proteins; Sulfonylurea Compounds; Thiazolidinediones; Treatment Outcome | 2015 |
Insulin and oral agents for managing cystic fibrosis-related diabetes.
Topics: Administration, Oral; Carbamates; Cystic Fibrosis; Diabetes Mellitus; Humans; Hyperglycemia; Hypoglycemic Agents; Insulin; Insulin Glargine; Insulin, Isophane; Piperidines; Randomized Controlled Trials as Topic | 2016 |
Effect of the treatment of Type 2 diabetes mellitus on the development of cognitive impairment and dementia.
Topics: Carbamates; Cause of Death; Cognition Disorders; Diabetes Mellitus, Type 2; Glyburide; Humans; Hypoglycemic Agents; Memory Disorders; Metformin; Piperidines; Randomized Controlled Trials as Topic; Rosiglitazone; Thiazolidinediones | 2017 |
Effects of CYP2C8 and SLCO1B1 Genetic Polymorphisms on Repaglinide Pharmacokinetics: A Systematic Review and Meta-Analysis.
Topics: Carbamates; Cytochrome P-450 CYP2C8; Hypoglycemic Agents; Liver-Specific Organic Anion Transporter 1; Piperidines; Polymorphism, Genetic | 2019 |
Metformin monotherapy for adults with type 2 diabetes mellitus.
Topics: Adult; Carbamates; Cardiovascular Diseases; Cause of Death; Diabetes Mellitus, Type 2; Dipeptidyl-Peptidase IV Inhibitors; Glucagon-Like Peptide 1; Humans; Hypoglycemic Agents; Insulin; Metformin; Myocardial Infarction; Piperidines; Quality of Life; Randomized Controlled Trials as Topic; Stroke; Sulfonylurea Compounds | 2020 |
Drug treatments for managing cystic fibrosis-related diabetes.
Topics: Administration, Oral; Bias; Blood Glucose; Carbamates; Cystic Fibrosis; Diabetes Mellitus; Fasting; Humans; Hyperglycemia; Hypoglycemic Agents; Insulin; Insulin Glargine; Insulin, Isophane; Piperidines; Randomized Controlled Trials as Topic | 2020 |
Pioglitazone for prevention or delay of type 2 diabetes mellitus and its associated complications in people at risk for the development of type 2 diabetes mellitus.
Topics: Acarbose; Bias; Carbamates; Cardiovascular Diseases; Confidence Intervals; Diabetes Mellitus, Type 2; Humans; Hypoglycemic Agents; Metformin; Pioglitazone; Piperidines; Placebos; Randomized Controlled Trials as Topic; Risk | 2020 |
A Review on Recent Controlled Release Strategies for Oral Drug Delivery of Repaglinide (a BCS Class II Drug).
Topics: Carbamates; Delayed-Action Preparations; Drug Delivery Systems; Liposomes; Nanoparticles; Piperidines | 2021 |
150 trial(s) available for carbamates and repaglinide
| Article | Year |
|---|---|
Comparative dose-related time-action profiles of glibenclamide and a new non-sulphonylurea drug, AG-EE 623 ZW, during euglycaemic clamp in healthy subjects.
Topics: Administration, Oral; Adult; Blood Glucose; Carbamates; Dose-Response Relationship, Drug; Glucose; Glucose Clamp Technique; Glyburide; Humans; Hypoglycemic Agents; Insulin; Insulin Secretion; Male; Piperidines; Time Factors | 1994 |
Effects of a new oral hypoglycaemic agent, repaglinide, on metabolic control in sulphonylurea-treated patients with NIDDM.
Topics: Aged; Blood Glucose; Carbamates; Diabetes Mellitus, Type 2; Female; Fructosamine; Gliclazide; Glyburide; Glycated Hemoglobin; Hexosamines; Humans; Hypoglycemic Agents; Lipids; Male; Middle Aged; Piperidines; Tolbutamide | 1993 |
Modulation of insulin secretion in non-insulin-dependent diabetes mellitus by two novel oral hypoglycaemic agents, NN623 and A4166.
Topics: Administration, Oral; Biological Availability; Blood Glucose; Carbamates; Cyclohexanes; Diabetes Mellitus, Type 2; Glyburide; Humans; Hypoglycemic Agents; Insulin; Insulin Secretion; Intestinal Absorption; Molecular Structure; Nateglinide; Phenylalanine; Piperidines; Reference Values; Stereoisomerism | 1996 |
A randomized placebo-controlled trial of repaglinide in the treatment of type 2 diabetes.
Topics: Adult; Aged; Carbamates; Diabetes Mellitus, Type 2; Double-Blind Method; Female; Humans; Hypoglycemic Agents; Male; Middle Aged; Piperidines | 1998 |
Bioavailability of repaglinide, a novel antidiabetic agent, administered orally in tablet or solution form or intravenously in healthy male volunteers.
Topics: Administration, Oral; Adolescent; Adult; Area Under Curve; Biological Availability; Carbamates; Cross-Over Studies; Diabetes Mellitus, Type 1; Humans; Hypoglycemic Agents; Infusions, Intravenous; Male; Middle Aged; Piperidines; Tablets | 1998 |
A 1-year multicenter randomized double-blind comparison of repaglinide and glyburide for the treatment of type 2 diabetes. Dutch and German Repaglinide Study Group.
Topics: Adult; Blood Glucose; Carbamates; Diabetes Mellitus, Type 2; Double-Blind Method; Fasting; Female; Glyburide; Glycated Hemoglobin; Humans; Hypoglycemic Agents; Male; Middle Aged; Piperidines | 1999 |
A double-blind randomized comparison of meal-related glycemic control by repaglinide and glyburide in well-controlled type 2 diabetic patients.
Topics: Adult; Aged; Blood Glucose; Carbamates; Diabetes Mellitus, Type 2; Diet, Diabetic; Double-Blind Method; Drug Administration Schedule; Eating; Energy Intake; Fasting; Glyburide; Humans; Hypoglycemic Agents; Middle Aged; Piperidines | 1999 |
Effect of repaglinide addition to metformin monotherapy on glycemic control in patients with type 2 diabetes.
Topics: Australia; Blood Glucose; C-Peptide; Carbamates; Cholesterol; Cholesterol, HDL; Cholesterol, LDL; Diabetes Mellitus, Type 2; Double-Blind Method; Drug Therapy, Combination; Fasting; Fatty Acids, Nonesterified; Female; Glycated Hemoglobin; Humans; Hypoglycemic Agents; Male; Metformin; Middle Aged; Piperidines; Triglycerides | 1999 |
Repaglinide pharmacokinetics in healthy young adult and elderly subjects.
Topics: Adult; Age Factors; Aged; Area Under Curve; Carbamates; Drug Administration Schedule; Female; Humans; Hypoglycemic Agents; Male; Piperidines; Single-Blind Method | 1999 |
Repaglinide versus glyburide: a one-year comparison trial.
Topics: Adult; Aged; Blood Glucose; C-Peptide; Carbamates; Cholesterol; Cholesterol, HDL; Cholesterol, LDL; Diabetes Mellitus, Type 2; Double-Blind Method; Female; Fibrinogen; Glyburide; Glycated Hemoglobin; Humans; Hypoglycemic Agents; Insulin; Male; Middle Aged; Piperidines; Prospective Studies; Triglycerides; United States; United States Food and Drug Administration | 1999 |
A comparison of repaglinide and glibenclamide in the treatment of type 2 diabetic patients previously treated with sulphonylureas.
Topics: Blood Glucose; Carbamates; Diabetes Mellitus, Type 2; Double-Blind Method; Female; Glyburide; Humans; Hypoglycemic Agents; Male; Middle Aged; Piperidines; Sulfonylurea Compounds | 1999 |
Flexible prandial glucose regulation with repaglinide in patients with type 2 diabetes.
Topics: Aged; Area Under Curve; Blood Glucose; Carbamates; Cholesterol; Diabetes Mellitus, Type 2; Eating; Female; Fructosamine; Humans; Hypoglycemic Agents; Indicators and Reagents; Male; Middle Aged; Nitroblue Tetrazolium; Piperidines; Prospective Studies; Triglycerides | 1999 |
Absorption, metabolism and excretion of a single oral dose of (14)C-repaglinide during repaglinide multiple dosing.
Topics: Absorption; Administration, Oral; Adolescent; Adult; Area Under Curve; Carbamates; Carbon Radioisotopes; Dose-Response Relationship, Drug; Erythrocytes; Humans; Hypoglycemic Agents; Male; Metabolic Clearance Rate; Piperidines; Time Factors; Tissue Distribution | 1999 |
Repaglinide in combination therapy with metformin in Type 2 diabetes.
Topics: Australia; Carbamates; Diabetes Mellitus, Type 2; Drug Therapy, Combination; Female; Glycated Hemoglobin; Humans; Hypoglycemia; Hypoglycemic Agents; Male; Metformin; Middle Aged; Piperidines | 1999 |
Repaglinide in type 2 diabetes: a 24-week, fixed-dose efficacy and safety study.
Topics: Adult; Aged; Blood Glucose; Carbamates; Diabetes Mellitus, Type 2; Dose-Response Relationship, Drug; Double-Blind Method; Fasting; Female; Humans; Hypoglycemic Agents; Male; Middle Aged; Patient Dropouts; Piperidines; Time Factors; Treatment Outcome | 2000 |
Single-dose pharmacokinetics of repaglinide in subjects with chronic liver disease.
Topics: Adult; Blood Glucose; Blood Proteins; Caffeine; Carbamates; Chronic Disease; Humans; Hypoglycemic Agents; Liver Diseases; Male; Middle Aged; Piperidines; Protein Binding | 2000 |
Pharmacokinetics of repaglinide in subjects with renal impairment.
Topics: Adult; Analysis of Variance; Area Under Curve; Carbamates; Creatinine; Female; Gas Chromatography-Mass Spectrometry; Humans; Hypoglycemic Agents; Kidney Diseases; Male; Middle Aged; Piperidines; Protein Binding; Renal Dialysis; Severity of Illness Index | 2000 |
Repaglinide acutely amplifies pulsatile insulin secretion by augmentation of burst mass with no effect on burst frequency.
Topics: Adult; Blood Glucose; C-Peptide; Carbamates; Cross-Over Studies; Double-Blind Method; Humans; Hypoglycemic Agents; Insulin; Insulin Secretion; Kinetics; Male; Piperidines; Placebos | 2000 |
Increased prandial insulin secretion after administration of a single preprandial oral dose of repaglinide in patients with type 2 diabetes.
Topics: Administration, Oral; Area Under Curve; Blood Glucose; C-Peptide; Carbamates; Cohort Studies; Cross-Over Studies; Diabetes Mellitus, Type 2; Double-Blind Method; Drug Administration Schedule; Eating; Humans; Hyperglycemia; Hypoglycemic Agents; Insulin; Insulin Secretion; Male; Middle Aged; Piperidines | 2000 |
Repaglinide/troglitazone combination therapy: improved glycemic control in type 2 diabetes.
Topics: Adult; Aged; Biomarkers; Blood Glucose; Carbamates; Chromans; Cross-Over Studies; Diabetes Mellitus, Type 2; Drug Therapy, Combination; Female; Glycated Hemoglobin; Humans; Hypoglycemic Agents; Male; Middle Aged; Piperidines; Thiazoles; Thiazolidinediones; Troglitazone | 2000 |
Rifampin decreases the plasma concentrations and effects of repaglinide.
Topics: Adult; Area Under Curve; Blood Glucose; Carbamates; Cross-Over Studies; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Drug Interactions; Enzyme Inhibitors; Female; Half-Life; Humans; Hypoglycemic Agents; Male; Mixed Function Oxygenases; Piperidines; Rifampin | 2000 |
Flexible meal-related dosing with repaglinide facilitates glycemic control in therapy-naive type 2 diabetes.
Topics: Aged; Blood Glucose; Body Weight; Carbamates; Diabetes Mellitus, Type 2; Diet; Double-Blind Method; Fasting; Female; Food; Glycated Hemoglobin; Humans; Hypoglycemia; Hypoglycemic Agents; Male; Middle Aged; Piperidines; Placebos | 2001 |
Mealtime glucose regulation with nateglinide in healthy volunteers: comparison with repaglinide and placebo.
Topics: Adolescent; Adult; Blood Glucose; Body Mass Index; Body Weight; Carbamates; Cross-Over Studies; Cyclohexanes; Female; Food; Humans; Hypoglycemic Agents; Insulin; Insulin Secretion; Kinetics; Male; Middle Aged; Nateglinide; Phenylalanine; Piperidines; Placebos; Time Factors | 2001 |
Single- and multiple-dose pharmacokinetics of repaglinide in patients with type 2 diabetes and renal impairment.
Topics: Aged; Analysis of Variance; Area Under Curve; Carbamates; Diabetes Mellitus, Type 2; Dose-Response Relationship, Drug; Female; Half-Life; Humans; Hypoglycemic Agents; Male; Metabolic Clearance Rate; Middle Aged; Piperidines; Renal Insufficiency | 2001 |
The cytochrome P4503A4 inhibitor clarithromycin increases the plasma concentrations and effects of repaglinide.
Topics: Adult; Analysis of Variance; Anti-Bacterial Agents; Blood Glucose; Carbamates; Clarithromycin; Cross-Over Studies; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Double-Blind Method; Drug Administration Schedule; Female; Humans; Hypoglycemic Agents; Insulin; Male; Mixed Function Oxygenases; Piperidines; Reference Values; Time Factors | 2001 |
Comparison between repaglinide and glipizide in Type 2 diabetes mellitus: a 1-year multicentre study.
Topics: Adult; Aged; Blood Glucose; C-Peptide; Carbamates; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Diabetic Neuropathies; Diabetic Retinopathy; Double-Blind Method; Fasting; Female; Glipizide; Glycated Hemoglobin; Humans; Hypoglycemic Agents; Insulin; Male; Middle Aged; Piperidines | 2001 |
Pharmacokinetics, pharmacodynamics, and dose-response relationship of repaglinide in type 2 diabetes.
Topics: Adult; Blood Glucose; Carbamates; Diabetes Mellitus, Type 2; Dose-Response Relationship, Drug; Double-Blind Method; Ethnicity; Fasting; Female; Humans; Hypoglycemic Agents; Insulin; Male; Middle Aged; Piperidines; Placebos; United States | 1999 |
Repaglinide improves blood glucose control in sulphonylurea-naive type 2 diabetes.
Topics: Area Under Curve; Blood Glucose; Carbamates; Diabetes Mellitus, Type 2; Double-Blind Method; Drug Administration Schedule; Fasting; Fructosamine; Glycated Hemoglobin; Humans; Hypoglycemic Agents; Insulin; Middle Aged; Piperidines; Placebos; Postprandial Period; Time Factors | 2001 |
Optimizing insulin secretagogue therapy in patients with type 2 diabetes: a randomized double-blind study with repaglinide.
Topics: Blood Glucose; Carbamates; Diabetes Mellitus, Type 2; Double-Blind Method; Eating; Humans; Hypoglycemic Agents; Insulin; Insulin Secretion; Middle Aged; Piperidines; Postprandial Period | 2002 |
Modeling the pharmacokinetics and pharmacodynamics of a unique oral hypoglycemic agent using neural networks.
Topics: Blood Glucose; Carbamates; Diabetes Mellitus, Type 2; Female; Humans; Hypoglycemic Agents; Male; Neural Networks, Computer; Piperidines; Predictive Value of Tests | 2002 |
Comparison of the effects of three insulinotropic drugs on plasma insulin levels after a standard meal.
Topics: Aged; Carbamates; Cross-Over Studies; Diabetes Mellitus, Type 2; Double-Blind Method; Eating; Female; Glipizide; Glyburide; Humans; Hypoglycemic Agents; Insulin; Insulin Secretion; Islets of Langerhans; Male; Middle Aged; Piperidines | 2002 |
Repaglinide versus glibenclamide treatment of Type 2 diabetes during Ramadan fasting.
Topics: Biomarkers; Carbamates; Diabetes Mellitus, Type 2; Fasting; Feeding Behavior; Female; Fructosamine; Glyburide; Humans; Hypoglycemia; Hypoglycemic Agents; Islam; Malaysia; Male; Middle Aged; Piperidines; Risk Factors; Safety; Time Factors | 2002 |
Repaglinide versus metformin in combination with bedtime NPH insulin in patients with type 2 diabetes established on insulin/metformin combination therapy.
Topics: Blood Glucose; Carbamates; Creatinine; Diabetes Mellitus, Type 2; Drug Administration Schedule; Drug Therapy, Combination; Female; Glycated Hemoglobin; Humans; Insulin, Isophane; Male; Metformin; Middle Aged; Piperidines; Time Factors | 2002 |
The effect of repaglinide on insulin secretion and oxidative stress in type 2 diabetic patients.
Topics: Carbamates; Diabetes Mellitus, Type 2; Female; Glucose Tolerance Test; Glycated Hemoglobin; Humans; Hypoglycemia; Hypoglycemic Agents; Insulin; Insulin Secretion; Male; Middle Aged; Oxidative Stress; Piperidines; Superoxide Dismutase; Treatment Outcome | 2003 |
Pharmacokinetics of repaglinide in healthy caucasian and Japanese subjects.
Topics: Adolescent; Adult; Asian People; Carbamates; Cross-Over Studies; Dose-Response Relationship, Drug; Humans; Hypoglycemic Agents; Male; Middle Aged; Piperidines; White People | 2003 |
Safety and efficacy of repaglinide in type 2 diabetic patients with and without impaired renal function.
Topics: Aged; Blood Glucose; Carbamates; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Female; Humans; Hypoglycemic Agents; Lipids; Male; Middle Aged; Piperidines; Severity of Illness Index | 2003 |
Effects of gemfibrozil, itraconazole, and their combination on the pharmacokinetics and pharmacodynamics of repaglinide: potentially hazardous interaction between gemfibrozil and repaglinide.
Topics: Adult; Antifungal Agents; Area Under Curve; Aryl Hydrocarbon Hydroxylases; Biotransformation; Blood Glucose; C-Peptide; Carbamates; Cross-Over Studies; Cytochrome P-450 CYP2C8; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Drug Interactions; Female; Gemfibrozil; Half-Life; Humans; Hypoglycemic Agents; Hypolipidemic Agents; Insulin; Itraconazole; Male; Piperidines | 2003 |
Comparison between repaglinide and glimepiride in patients with type 2 diabetes mellitus: a one-year, randomized, double-blind assessment of metabolic parameters and cardiovascular risk factors.
Topics: Blood Glucose; Blood Pressure; Carbamates; Diabetes Mellitus, Type 2; Double-Blind Method; Female; Homocysteine; Humans; Hypoglycemic Agents; Lipoprotein(a); Male; Middle Aged; Piperidines; Plasminogen Activator Inhibitor 1; Risk Factors; Sulfonylurea Compounds; Time Factors; Treatment Outcome | 2003 |
Comparison of glycaemic control and cardiovascular risk profile in patients with type 2 diabetes during treatment with either repaglinide or metformin.
Topics: Blood Glucose; Carbamates; Cardiovascular Diseases; Diabetes Mellitus, Type 2; Female; Humans; Hypoglycemic Agents; Insulin; Lipoproteins; Male; Metformin; Middle Aged; Piperidines; Prospective Studies; Risk Factors; Triglycerides | 2003 |
The effect of prandial glucose regulation with repaglinide on treatment satisfaction, wellbeing and health status in patients with pharmacotherapy naïve Type 2 diabetes: a placebo-controlled, multicentre study.
Topics: Carbamates; Diabetes Mellitus, Type 2; Double-Blind Method; Health Status; Health Status Indicators; Humans; Hypoglycemic Agents; Patient Satisfaction; Piperidines; Prospective Studies; Quality of Life; Surveys and Questionnaires; Translating | 2003 |
Influence of drugs interacting with CYP3A4 on the pharmacokinetics, pharmacodynamics, and safety of the prandial glucose regulator repaglinide.
Topics: Adult; Area Under Curve; Blood Glucose; Carbamates; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Drug Interactions; Female; Half-Life; Humans; Hypoglycemic Agents; Ketoconazole; Male; Piperidines; Rifampin; Simvastatin | 2003 |
Efficacy and safety of combination therapy: repaglinide plus metformin versus nateglinide plus metformin.
Topics: Area Under Curve; Blood Glucose; Carbamates; Cyclohexanes; Diabetes Mellitus, Type 2; Drug Therapy, Combination; Female; Glycated Hemoglobin; Humans; Hypoglycemic Agents; Insulin; Male; Metformin; Middle Aged; Nateglinide; Phenylalanine; Piperidines; Postprandial Period; Safety | 2003 |
Lack of effect of acute repaglinide administration on postprandial lipaemia in patients with type 2 diabetes mellitus.
Topics: Analysis of Variance; Blood Glucose; C-Peptide; Carbamates; Cholesterol; Diabetes Mellitus, Type 2; Fatty Acids, Nonesterified; Glycated Hemoglobin; Humans; Hyperlipidemias; Hypoglycemic Agents; Insulin; Kinetics; Piperidines; Postprandial Period; Triglycerides | 2003 |
Polymorphism in CYP2C8 is associated with reduced plasma concentrations of repaglinide.
Topics: Adult; Alleles; Area Under Curve; Aryl Hydrocarbon Hydroxylases; Blood Glucose; Carbamates; Cytochrome P-450 CYP2C8; Female; Genotype; Half-Life; Humans; Hypoglycemic Agents; Linear Models; Male; Piperidines; Polymorphism, Genetic | 2003 |
Comparison of repaglinide vs. gliclazide in combination with bedtime NPH insulin in patients with Type 2 diabetes inadequately controlled with oral hypoglycaemic agents.
Topics: Administration, Oral; Blood Glucose; Carbamates; Diabetes Mellitus, Type 2; Drug Therapy, Combination; Female; Gliclazide; Hemoglobin A; Humans; Hypoglycemic Agents; Insulin, Isophane; Male; Metformin; Middle Aged; Patient Satisfaction; Piperidines; Surveys and Questionnaires; Weight Gain | 2003 |
The insulin secretagogues glibenclamide and repaglinide do not influence growth hormone secretion in humans but stimulate glucagon secretion during profound insulin deficiency.
Topics: Blood Glucose; C-Peptide; Carbamates; Diabetes Mellitus, Type 1; Fatty Acids, Nonesterified; Glucagon; Glucose Clamp Technique; Glyburide; Growth Hormone-Releasing Hormone; Human Growth Hormone; Humans; Hypoglycemic Agents; Insulin; Piperidines; Placebos; Potassium Channel Blockers; Somatostatin | 2004 |
Treatment of type 2 diabetes with a combination regimen of repaglinide plus pioglitazone.
Topics: Adult; Aged; Aged, 80 and over; Blood Glucose; Carbamates; Diabetes Mellitus, Type 2; Drug Therapy, Combination; Glycated Hemoglobin; Humans; Hypoglycemia; Hypoglycemic Agents; Lipids; Middle Aged; Pioglitazone; Piperidines; Thiazolidinediones | 2004 |
The CYP2C8 inhibitor trimethoprim increases the plasma concentrations of repaglinide in healthy subjects.
Topics: Adult; Aryl Hydrocarbon Hydroxylases; Biotransformation; Carbamates; Cross-Over Studies; Cytochrome P-450 CYP2C8; Diabetes Mellitus; Double-Blind Method; Drug Interactions; Female; Humans; Hypoglycemic Agents; Male; Piperidines; Trimethoprim | 2004 |
Repaglinide is more efficient than glimepiride on insulin secretion and post-prandial glucose excursions in patients with type 2 diabetes. A short term study.
Topics: Aged; Aged, 80 and over; Blood Glucose; C-Peptide; Carbamates; Cholesterol; Diabetes Mellitus, Type 2; Female; Glucose Clamp Technique; Humans; Hypoglycemic Agents; Insulin; Insulin Secretion; Islets of Langerhans; Kinetics; Male; Middle Aged; Piperidines; Postprandial Period; Sulfonylurea Compounds; Time Factors; Triglycerides | 2004 |
Rifampicin seems to act as both an inducer and an inhibitor of the metabolism of repaglinide.
Topics: Administration, Oral; Adolescent; Adult; Anti-Bacterial Agents; Area Under Curve; Aryl Hydrocarbon Hydroxylases; Carbamates; Chromatography, High Pressure Liquid; Cross-Over Studies; Cytochrome P-450 CYP2C8; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Drug Interactions; Enzyme Induction; Humans; Hydrocortisone; Hypoglycemic Agents; Male; Middle Aged; Piperidines; Quinidine; Rifampin; Time Factors | 2004 |
Dose titration of repaglinide in patients with inadequately controlled type 2 diabetes.
Topics: Adult; Blood Glucose; Carbamates; Diabetes Mellitus, Type 2; Dose-Response Relationship, Drug; Fasting; Female; Glycated Hemoglobin; Humans; Hypoglycemic Agents; Male; Piperidines; Postprandial Period; Safety | 2004 |
Combination therapy for type 2 diabetes: repaglinide plus rosiglitazone.
Topics: Blood Glucose; Carbamates; Diabetes Mellitus, Type 2; Drug Therapy, Combination; Female; Glycated Hemoglobin; Humans; Hypoglycemia; Hypoglycemic Agents; Male; Middle Aged; Piperidines; Rosiglitazone; Thiazolidinediones; Treatment Outcome; Weight Gain | 2004 |
Repaglinide versus nateglinide monotherapy: a randomized, multicenter study.
Topics: Biomarkers; Body Mass Index; Carbamates; Cyclohexanes; Diabetes Mellitus, Type 2; Diet, Diabetic; Exercise; Female; Glycated Hemoglobin; Humans; Hypoglycemic Agents; Male; Middle Aged; Nateglinide; Phenylalanine; Piperidines; Time Factors | 2004 |
Regression of carotid atherosclerosis by control of postprandial hyperglycemia in type 2 diabetes mellitus.
Topics: Adult; Aged; Biomarkers; Blood Glucose; Carbamates; Carotid Artery Diseases; Cross-Sectional Studies; Diabetes Mellitus, Type 2; Fasting; Female; Glyburide; Glycated Hemoglobin; Humans; Hyperglycemia; Hypoglycemic Agents; Inflammation; Insulin; Lipids; Male; Middle Aged; Piperidines; Postprandial Period; Single-Blind Method; Tunica Intima; Tunica Media; Ultrasonography | 2004 |
Enhancement of early- and late-phase insulin secretion and insulin sensitivity by the combination of repaglinide and metformin in type 2 diabetes mellitus.
Topics: Adult; Aged; C-Peptide; Carbamates; Cohort Studies; Cross-Over Studies; Diabetes Mellitus, Type 2; Drug Synergism; Drug Therapy, Combination; Female; Glucose Clamp Technique; Humans; Hypoglycemic Agents; Insulin; Insulin Secretion; Male; Metformin; Middle Aged; Piperidines; Placebos; Time Factors | 2004 |
Modification of beta-cell response to different postprandial blood glucose concentrations by prandial repaglinide and combined acarbose/repaglinide application.
Topics: Acarbose; Adult; Aged; Blood Glucose; C-Peptide; Carbamates; Cross-Over Studies; Diabetes Mellitus, Type 2; Drug Therapy, Combination; Female; Food; Humans; Hypoglycemic Agents; Insulin; Islets of Langerhans; Male; Middle Aged; Piperidines; Proinsulin | 2004 |
Beta-cell insulin secretory response to oral hypoglycemic agents is blunted in humans in vivo during moderate hypoglycemia.
Topics: Administration, Oral; Adult; Carbamates; Cross-Over Studies; Double-Blind Method; Female; Glipizide; Glucose; Humans; Hypoglycemia; Hypoglycemic Agents; Insulin; Insulin Secretion; Islets of Langerhans; Male; Piperidines | 2004 |
Lack of effect of bezafibrate and fenofibrate on the pharmacokinetics and pharmacodynamics of repaglinide.
Topics: Adult; Bezafibrate; Blood Glucose; Carbamates; Cross-Over Studies; Delayed-Action Preparations; Drug Interactions; Fenofibrate; Humans; Hypolipidemic Agents; Male; Piperidines; Tablets | 2004 |
The combination oral and nutritional treatment of late-onset diabetes mellitus (CONTROL DM) trial results.
Topics: Administration, Oral; Adult; Aged; Brachial Artery; Carbamates; Combined Modality Therapy; Diabetes Mellitus, Type 2; Drug Therapy, Combination; Female; Humans; Hypoglycemic Agents; Male; Metformin; Middle Aged; Piperidines; Treatment Outcome; Vasodilation | 2004 |
The effects of diet, sulfonylurea, and Repaglinide therapy on clinical and metabolic parameters in type 2 diabetic patients during Ramadan.
Topics: 3-Hydroxybutyric Acid; Blood Glucose; Carbamates; Cholesterol, HDL; Diabetes Mellitus, Type 2; Fasting; Humans; Hypoglycemic Agents; Islam; Middle Aged; Piperidines; Postprandial Period; Sulfonylurea Compounds; Triglycerides | 2004 |
Pre-prandial vs. post-prandial capillary glucose measurements as targets for repaglinide dose titration in people with diet-treated or metformin-treated Type 2 diabetes: a randomized controlled clinical trial.
Topics: Adult; Aged; Blood Glucose; Blood Specimen Collection; Carbamates; Diabetes Mellitus, Type 2; Drug Administration Schedule; Drug Monitoring; Drug Therapy, Combination; Female; Glycated Hemoglobin; Humans; Hypoglycemic Agents; Male; Metformin; Middle Aged; Piperidines; Postprandial Period | 2004 |
Effect of repaglinide and gliclazide on postprandial control of endogenous glucose production.
Topics: Adult; Carbamates; Diabetes Mellitus, Type 2; Fatty Acids, Nonesterified; Female; Gliclazide; Glucagon; Glucose; Humans; Hypoglycemic Agents; Insulin; Male; Middle Aged; Oxidation-Reduction; Piperidines; Postprandial Period | 2005 |
Repaglinide administration improves brachial reactivity in type 2 diabetic patients.
Topics: Aged; Blood Glucose; Brachial Artery; Carbamates; Cross-Over Studies; Diabetes Mellitus, Type 2; Diabetic Angiopathies; Endothelium, Vascular; Female; Glyburide; Humans; Hypoglycemic Agents; Male; Middle Aged; Oxidative Stress; Piperidines | 2005 |
Clinical experience with repaglinide in patients with non-insulin-dependent diabetes mellitus.
Topics: Adult; Aged; Aged, 80 and over; Blood Glucose; Body Weight; Carbamates; Diabetes Mellitus, Type 2; Diet; Feeding Behavior; Female; Humans; Hypoglycemic Agents; Male; Middle Aged; Piperidines; Stereoisomerism; Treatment Outcome | 2005 |
[Comparison of efficacy between nateglinide and repaglinide in treating type 2 diabetes: a randomized controlled double-blind clinical trial].
Topics: Adult; Blood Glucose; Carbamates; Cyclohexanes; Diabetes Mellitus, Type 2; Double-Blind Method; Female; Humans; Hypoglycemic Agents; Insulin; Insulin Secretion; Male; Middle Aged; Nateglinide; Phenylalanine; Piperidines | 2005 |
Beta-cell response during a meal test: a comparative study of incremental doses of repaglinide in type 2 diabetic patients.
Topics: Adult; Aged; Blood Glucose; C-Peptide; Carbamates; Cross-Over Studies; Diabetes Mellitus, Type 2; Eating; Female; Humans; Hypoglycemic Agents; Insulin; Insulin Secretion; Islets of Langerhans; Male; Middle Aged; Piperidines; Postprandial Period | 2005 |
Repaglinide/bedtime NPH insulin is comparable to twice-daily NPH insulin.
Topics: Adult; Blood Glucose; Body Mass Index; Carbamates; Diabetes Mellitus, Type 2; Drug Administration Schedule; Female; Glycated Hemoglobin; Humans; Hypoglycemic Agents; Insulin, Isophane; Male; Patient Dropouts; Piperidines | 2005 |
Repaglinide has more beneficial effect on cardiovascular risk factors than glimepiride: data from meal-test study.
Topics: Aged; Aged, 80 and over; Area Under Curve; Blood Glucose; Carbamates; Cardiovascular Diseases; Cross-Over Studies; Diabetes Mellitus, Type 2; Diabetic Angiopathies; Diet, Diabetic; Eating; Female; Humans; Hypoglycemic Agents; Insulin; Lipids; Male; Middle Aged; Piperidines; Sulfonylurea Compounds; Thiobarbituric Acid Reactive Substances | 2005 |
Repaglinide treatment amplifies first-phase insulin secretion and high-frequency pulsatile insulin release in Type 2 diabetes.
Topics: Administration, Oral; Adult; Aged; Blood Glucose; Carbamates; Cross-Over Studies; Diabetes Mellitus, Type 2; Double-Blind Method; Female; Homeostasis; Humans; Hypoglycemic Agents; Insulin; Insulin Secretion; Male; Middle Aged; Piperidines; Secretory Rate | 2005 |
Cyclosporine markedly raises the plasma concentrations of repaglinide.
Topics: Adult; Aryl Hydrocarbon Hydroxylases; ATP Binding Cassette Transporter, Subfamily B, Member 1; Blood Glucose; Carbamates; Cross-Over Studies; Cyclosporine; Cytochrome P-450 CYP2C8; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Drug Synergism; Genotype; Humans; Hypoglycemic Agents; Immunosuppressive Agents; In Vitro Techniques; Liver-Specific Organic Anion Transporter 1; Male; Microsomes, Liver; Organic Anion Transporters; Piperidines; Polymorphism, Single Nucleotide | 2005 |
The impact of CYP2C8 polymorphism and grapefruit juice on the pharmacokinetics of repaglinide.
Topics: Administration, Oral; Adult; Area Under Curve; Aryl Hydrocarbon Hydroxylases; Beverages; Blood Glucose; Carbamates; Citrus paradisi; Cross-Over Studies; Cytochrome P-450 CYP2C8; Genotype; Humans; Hypoglycemic Agents; Male; Piperidines; Polymorphism, Genetic; Quinidine | 2006 |
Meal-induced platelet activation in Type 2 diabetes mellitus: effects of treatment with repaglinide and glibenclamide.
Topics: Adenosine Diphosphate; Blood Glucose; C-Reactive Protein; Carbamates; Cross-Over Studies; Diabetes Mellitus, Type 2; Eating; Fasting; Female; Glyburide; Humans; Hypoglycemic Agents; Insulin; Intercellular Adhesion Molecule-1; Male; Middle Aged; P-Selectin; Piperidines; Platelet Activation; Platelet Function Tests; Postprandial Period; Treatment Outcome; von Willebrand Factor | 2006 |
Pioglitazone, an in vitro inhibitor of CYP2C8 and CYP3A4, does not increase the plasma concentrations of the CYP2C8 and CYP3A4 substrate repaglinide.
Topics: Administration, Oral; Adult; Area Under Curve; Aryl Hydrocarbon Hydroxylases; Blood Glucose; Capsules; Carbamates; Chromatography, Liquid; Cross-Over Studies; Cytochrome P-450 CYP2C8; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Drug Administration Schedule; Enzyme Inhibitors; Female; Gas Chromatography-Mass Spectrometry; Half-Life; Humans; Hypoglycemic Agents; In Vitro Techniques; Male; Pioglitazone; Piperidines; Substrate Specificity; Thiazolidinediones | 2006 |
Telithromycin, but not montelukast, increases the plasma concentrations and effects of the cytochrome P450 3A4 and 2C8 substrate repaglinide.
Topics: Acetates; Adolescent; Adult; Area Under Curve; Aryl Hydrocarbon Hydroxylases; Biotransformation; Blood Glucose; Carbamates; Cross-Over Studies; Cyclopropanes; Cytochrome P-450 CYP2C8; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Drug Interactions; Female; Humans; Hypoglycemic Agents; Ketolides; Leukotriene Antagonists; Male; Piperidines; Quinolines; Sulfides | 2006 |
Repaglinide in the management of new-onset diabetes mellitus after renal transplantation.
Topics: Carbamates; Diabetes Mellitus; Female; Humans; Hypoglycemic Agents; Kidney Transplantation; Male; Middle Aged; Piperidines; Rosiglitazone; Thiazolidinediones; Treatment Outcome | 2006 |
Effect of repaglinide on endothelial dysfunction during a glucose tolerance test in subjects with impaired glucose tolerance.
Topics: Aged; Blood Glucose; Carbamates; Cross-Over Studies; Endothelium, Vascular; Female; Glucose Intolerance; Glucose Tolerance Test; Humans; Male; Middle Aged; Piperidines; Prospective Studies; Vascular Diseases | 2006 |
An open label comparative study of glimepiride versus repaglinide in type 2 diabetes mellitus Muslim subjects during the month of Ramadan.
Topics: Adult; Aged; Blood Glucose; Carbamates; Ceremonial Behavior; Diabetes Mellitus, Type 2; Fasting; Female; Humans; Hypoglycemic Agents; Islam; Male; Middle Aged; Piperidines; Sulfonylurea Compounds; Time Factors; Treatment Outcome | 2006 |
Safety of type 2 diabetes treatment with repaglinide compared with glibenclamide in elderly people: A randomized, open-label, two-period, cross-over trial.
Topics: Aged; Carbamates; Cross-Over Studies; Diabetes Mellitus, Type 2; Glyburide; Humans; Piperidines | 2006 |
Effect of a hypoglycemic agent on ischemic preconditioning in patients with type 2 diabetes and stable angina pectoris.
Topics: Angina Pectoris; Carbamates; Diabetes Mellitus, Type 2; Electrocardiography; Exercise Test; Female; Humans; Hypoglycemic Agents; Ischemic Preconditioning, Myocardial; Male; Middle Aged; Piperidines; Time Factors | 2007 |
Preprandial repaglinide decreases exogenous insulin requirements and HbA1c levels in type 2 diabetic patients taking intensive insulin treatment.
Topics: Body Mass Index; Carbamates; Diabetes Mellitus, Type 2; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Glycated Hemoglobin; Humans; Hypoglycemic Agents; Insulin; Male; Middle Aged; Piperidines | 2006 |
Twelve weeks' treatment with diazoxide without insulin supplementation in Type 2 diabetes is feasible but does not improve insulin secretion.
Topics: Carbamates; Diabetes Mellitus, Type 2; Diazoxide; Dose-Response Relationship, Drug; Female; Humans; Hypoglycemic Agents; Insulin; Insulin Secretion; Insulin-Secreting Cells; Male; Metformin; Middle Aged; Piperidines; Treatment Outcome | 2007 |
Targeting hyperglycaemia with either metformin or repaglinide in non-obese patients with type 2 diabetes: results from a randomized crossover trial.
Topics: Adiponectin; Biomarkers; Blood Glucose; Body Weight; C-Peptide; C-Reactive Protein; Carbamates; Cross-Over Studies; Diabetes Mellitus, Type 2; Double-Blind Method; Female; Glycated Hemoglobin; Humans; Hyperglycemia; Hypoglycemic Agents; Insulin; Male; Metformin; Middle Aged; Patient Compliance; Piperidines; Prospective Studies; Waist-Hip Ratio | 2007 |
A randomized controlled trial examining combinations of repaglinide, metformin and NPH insulin.
Topics: Adult; Aged; Aged, 80 and over; Carbamates; Diabetes Mellitus, Type 2; Drug Administration Schedule; Drug Therapy, Combination; Female; Humans; Hypoglycemia; Hypoglycemic Agents; Insulin, Isophane; Male; Metformin; Middle Aged; Piperidines; Treatment Outcome; Weight Gain | 2007 |
Improvement of insulin sensitivity and beta-cell function by nateglinide and repaglinide in type 2 diabetic patients - a randomized controlled double-blind and double-dummy multicentre clinical trial.
Topics: Adult; Age of Onset; Aged; Area Under Curve; Asian People; Blood Glucose; Carbamates; China; Cyclohexanes; Diabetes Mellitus, Type 2; Double-Blind Method; Humans; Insulin; Insulin Secretion; Insulin-Secreting Cells; Middle Aged; Nateglinide; Phenylalanine; Piperidines | 2007 |
Safety and efficacy of repaglinide in combination with metformin and bedtime NPH insulin as an insulin treatment regimen in type 2 diabetes.
Topics: Aged; Blood Glucose; Blood Pressure; Body Mass Index; Carbamates; Diabetes Mellitus, Type 2; Drug Administration Schedule; Drug Therapy, Combination; Female; Glycated Hemoglobin; Humans; Insulin, Isophane; Male; Metformin; Middle Aged; Piperidines; Prospective Studies; Safety; Weight Gain | 2008 |
Impact of metformin versus the prandial insulin secretagogue, repaglinide, on fasting and postprandial glucose and lipid responses in non-obese patients with type 2 diabetes.
Topics: Aged; Area Under Curve; Blood Glucose; Carbamates; Cholesterol; Cholesterol, LDL; Cross-Over Studies; Diabetes Mellitus, Type 2; Double-Blind Method; Fasting; Fatty Acids, Nonesterified; Female; Humans; Hypoglycemic Agents; Insulin; Lipids; Male; Metformin; Middle Aged; Piperidines; Postprandial Period; Triglycerides | 2008 |
Therapeutic options for elderly diabetic subjects: open label, randomized clinical trial of insulin glargine added to oral antidiabetic drugs versus increased dosage of oral antidiabetic drugs.
Topics: Administration, Oral; Aged; Blood Glucose; Body Mass Index; Carbamates; Drug Therapy, Combination; Female; Gliclazide; Glycated Hemoglobin; Humans; Hypoglycemic Agents; Insulin; Insulin Glargine; Insulin, Long-Acting; Male; Metformin; Pioglitazone; Piperidines; Research Design; Rosiglitazone; Thiazolidinediones | 2008 |
Different effects of SLCO1B1 polymorphism on the pharmacokinetics and pharmacodynamics of repaglinide and nateglinide.
Topics: Analysis of Variance; Area Under Curve; Aryl Hydrocarbon Hydroxylases; Blood Glucose; Carbamates; Chromatography, Liquid; Cyclohexanes; Cytochrome P-450 CYP2C8; Cytochrome P-450 CYP2C9; Dose-Response Relationship, Drug; Genotype; Half-Life; Humans; Hypoglycemic Agents; Liver-Specific Organic Anion Transporter 1; Metabolic Clearance Rate; Molecular Structure; Nateglinide; Organic Anion Transporters; Pharmacogenetics; Phenylalanine; Piperidines; Polymorphism, Single Nucleotide; Tablets; Tandem Mass Spectrometry | 2008 |
The effect of gemfibrozil on repaglinide pharmacokinetics persists for at least 12 h after the dose: evidence for mechanism-based inhibition of CYP2C8 in vivo.
Topics: Adult; Area Under Curve; Aryl Hydrocarbon Hydroxylases; Blood Glucose; Carbamates; Cytochrome P-450 CYP2C8; Drug Interactions; Female; Gemfibrozil; Glucuronates; Half-Life; Humans; Hypoglycemic Agents; Hypolipidemic Agents; Male; Piperidines | 2008 |
Impact of metformin versus repaglinide on non-glycaemic cardiovascular risk markers related to inflammation and endothelial dysfunction in non-obese patients with type 2 diabetes.
Topics: Aged; Blood Glucose; Body Weight; Carbamates; Cross-Over Studies; Diabetes Mellitus, Type 2; Diabetic Angiopathies; Endothelium, Vascular; Female; Humans; Hypoglycemic Agents; Male; Metformin; Middle Aged; Piperidines; Risk Factors; Treatment Outcome; Vasculitis | 2008 |
Fixed-dose combination tablet of repaglinide and metformin is bioequivalent to concomitantly administered individual tablets of repaglinide and metformin : randomized, single-blind, three-period crossover study in healthy subjects.
Topics: Adolescent; Adult; Area Under Curve; Carbamates; Cross-Over Studies; Drug Combinations; Drug Therapy, Combination; Female; Humans; Hypoglycemic Agents; Male; Metformin; Middle Aged; Piperidines; Sample Size; Single-Blind Method; Therapeutic Equivalency; Young Adult | 2008 |
Differential lipid profile and hormonal response in type 2 diabetes by exogenous insulin aspart versus the insulin secretagogue repaglinide, at the same glycemic control.
Topics: Aged; Apolipoproteins; Blood Glucose; C-Peptide; Carbamates; Cholesterol; Cross-Over Studies; Diabetes Mellitus, Type 2; Drug Administration Schedule; Female; Humans; Hypoglycemic Agents; Insulin; Insulin Aspart; Insulin-Like Growth Factor Binding Protein 1; Insulin-Like Growth Factor I; Lipids; Lipoproteins; Male; Middle Aged; Piperidines; Proinsulin | 2009 |
Effects of the SLCO1B1*1B haplotype on the pharmacokinetics and pharmacodynamics of repaglinide and nateglinide.
Topics: Administration, Oral; Adult; Area Under Curve; Blood Glucose; Carbamates; Cyclohexanes; Female; Haplotypes; Humans; Hypoglycemic Agents; Liver-Specific Organic Anion Transporter 1; Male; Nateglinide; Organic Anion Transporters; Phenylalanine; Piperidines; Time Factors | 2008 |
Nateglinide versus repaglinide for type 2 diabetes mellitus in China.
Topics: Carbamates; China; Cyclohexanes; Diabetes Mellitus, Type 2; Female; Glycated Hemoglobin; Humans; Hypoglycemic Agents; Male; Middle Aged; Nateglinide; Phenylalanine; Piperidines | 2009 |
Metabolic effect of repaglinide or acarbose when added to a double oral antidiabetic treatment with sulphonylureas and metformin: a double-blind, cross-over, clinical trial.
Topics: Acarbose; Administration, Oral; Adult; Blood Glucose; Carbamates; Cross-Over Studies; Diabetes Mellitus, Type 2; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Hypoglycemic Agents; Male; Metformin; Middle Aged; Piperidines; Sulfonylurea Compounds | 2009 |
Effects of gemfibrozil and atorvastatin on the pharmacokinetics of repaglinide in relation to SLCO1B1 polymorphism.
Topics: Administration, Oral; Adult; Area Under Curve; Atorvastatin; Blood Glucose; Carbamates; Cross-Over Studies; Drug Interactions; Female; Gemfibrozil; Genotype; Half-Life; Heptanoic Acids; Humans; Hypoglycemic Agents; Hypolipidemic Agents; Liver-Specific Organic Anion Transporter 1; Male; Organic Anion Transporters; Piperidines; Polymorphism, Genetic; Pyrroles | 2008 |
The investigation of the efficacy of insulin glargine on glycemic control when combined with either repaglinide or acarbose in obese Type 2 diabetic patients.
Topics: Acarbose; Blood Glucose; Carbamates; Diabetes Mellitus, Type 2; Drug Therapy, Combination; Female; Glycated Hemoglobin; Humans; Hypoglycemia; Hypoglycemic Agents; Insulin; Insulin Glargine; Insulin, Long-Acting; Male; Middle Aged; Obesity; Piperidines; Weight Gain | 2009 |
Twice-daily dosing of a repaglinide/metformin fixed-dose combination tablet provides glycaemic control comparable to rosiglitazone/metformin tablet.
Topics: Administration, Oral; Adult; Aged; Aged, 80 and over; Blood Glucose; Carbamates; Diabetes Mellitus, Type 2; Drug Administration Schedule; Drug Therapy, Combination; Female; Glycated Hemoglobin; Humans; Hypoglycemic Agents; Lipids; Male; Metformin; Middle Aged; Patient Satisfaction; Piperidines; Rosiglitazone; Tablets; Thiazolidinediones; Young Adult | 2009 |
Twice-daily and three-times-daily dosing of a repaglinide/metformin fixed-dose combination tablet provide similar glycaemic control.
Topics: Adult; Blood Glucose; Carbamates; Diabetes Mellitus, Type 2; Drug Administration Schedule; Drug Therapy, Combination; Female; Glycated Hemoglobin; Humans; Hypoglycemia; Hypoglycemic Agents; Male; Metformin; Middle Aged; Patient Satisfaction; Piperidines; Tablets; Young Adult | 2009 |
Evaluation of the repaglinide efficiency in comparison to the glimepiride in the type 2 diabetes patients poorly regulated by the metmorfine administration.
Topics: Blood Glucose; Carbamates; Diabetes Mellitus, Type 2; Drug Therapy, Combination; Female; Glycated Hemoglobin; Humans; Hypoglycemic Agents; Male; Metformin; Middle Aged; Piperidines; Sulfonylurea Compounds | 2009 |
CYP2C8 activity recovers within 96 hours after gemfibrozil dosing: estimation of CYP2C8 half-life using repaglinide as an in vivo probe.
Topics: Administration, Oral; Area Under Curve; Aryl Hydrocarbon Hydroxylases; Biotransformation; Blood Glucose; Carbamates; Cross-Over Studies; Cytochrome P-450 CYP2C8; Drug Interactions; Enzyme Inhibitors; Female; Gemfibrozil; Genotype; Glucuronates; Half-Life; Humans; Hypoglycemic Agents; Hypolipidemic Agents; Liver-Specific Organic Anion Transporter 1; Male; Models, Biological; Molecular Probes; Organic Anion Transporters; Phenotype; Piperidines; Young Adult | 2009 |
Combining insulin with metformin or an insulin secretagogue in non-obese patients with type 2 diabetes: 12 month, randomised, double blind trial.
Topics: Blood Glucose; Carbamates; Diabetes Mellitus, Type 2; Double-Blind Method; Drug Therapy, Combination; Female; Glycated Hemoglobin; Humans; Hypoglycemia; Hypoglycemic Agents; Insulin; Insulin Aspart; Male; Metformin; Middle Aged; Patient Compliance; Piperidines; Treatment Outcome; Weight Gain | 2009 |
Investigation of the pharmacokinetic interactions of deferasirox, a once-daily oral iron chelator, with midazolam, rifampin, and repaglinide in healthy volunteers.
Topics: Adult; Anesthetics, Intravenous; Aryl Hydrocarbon Hydroxylases; Benzoates; Carbamates; Cross-Over Studies; Cytochrome P-450 CYP2C8; Cytochrome P-450 CYP3A; Deferasirox; Drug Interactions; Enzyme Inhibitors; Female; Humans; Hypoglycemic Agents; Iron Chelating Agents; Male; Midazolam; Piperidines; Rifampin; Triazoles | 2010 |
KCNJ11 Lys23Glu and TCF7L2 rs290487(C/T) polymorphisms affect therapeutic efficacy of repaglinide in Chinese patients with type 2 diabetes.
Topics: Adult; Alleles; Amino Acid Substitution; Asian People; Blood Glucose; Carbamates; Diabetes Mellitus, Type 2; Female; Glutamic Acid; Humans; Lysine; Male; Middle Aged; Piperidines; Polymorphism, Genetic; Potassium Channels, Inwardly Rectifying; Risk Factors; TCF Transcription Factors; Transcription Factor 7-Like 2 Protein; Treatment Outcome | 2010 |
Effects of short-term therapy with different insulin secretagogues on glucose metabolism, lipid parameters and oxidative stress in newly diagnosed Type 2 Diabetes Mellitus.
Topics: Adult; Aged; Analysis of Variance; Blood Glucose; Carbamates; Chi-Square Distribution; Diabetes Mellitus, Type 2; Female; Fructosamine; Gliclazide; Glycated Hemoglobin; Humans; Hypoglycemic Agents; Insulin; Lipid Peroxidation; Lipids; Male; Middle Aged; Oxidative Stress; Piperidines; Postprandial Period; Sulfonylurea Compounds; Treatment Outcome | 2010 |
Effect of meglitinides on postprandial ghrelin secretion pattern in type 2 diabetes mellitus.
Topics: Adult; Aged; Benzamides; Blood Glucose; Body Mass Index; C-Peptide; Carbamates; Cross-Over Studies; Diabetes Mellitus, Type 2; Eating; Feeding Behavior; Ghrelin; Glycated Hemoglobin; Humans; Hypoglycemic Agents; Insulin; Metformin; Middle Aged; Piperidines; Reference Values; Single-Blind Method | 2010 |
Comparison of insulin sensitivity, glucose sensitivity, and first phase insulin secretion in patients treated with repaglinide or gliclazide.
Topics: Adult; Blood Glucose; Blood Pressure; Body Mass Index; Carbamates; Cross-Over Studies; Diabetes Mellitus, Type 2; Female; Gliclazide; Glucose Tolerance Test; Glycated Hemoglobin; Humans; Hypoglycemic Agents; Insulin; Insulin Resistance; Lipids; Male; Middle Aged; Piperidines; Time Factors; Treatment Outcome | 2010 |
Effect of repaglinide versus glyburide on postprandial glucose and insulin values in elderly patients with type 2 diabetes.
Topics: Aged; Area Under Curve; Blood Glucose; Carbamates; Cross-Over Studies; Diabetes Mellitus, Type 2; Female; Glyburide; Humans; Hypoglycemic Agents; Insulin; Male; Piperidines; Postprandial Period | 2011 |
Improved glycemic control induced by both metformin and repaglinide is associated with a reduction in blood levels of 3-deoxyglucosone in nonobese patients with type 2 diabetes.
Topics: Carbamates; Confidence Intervals; Deoxyglucose; Diabetes Mellitus, Type 2; Humans; Hypoglycemic Agents; Metformin; Piperidines | 2011 |
Effects of KCNQ1 polymorphisms on the therapeutic efficacy of oral antidiabetic drugs in Chinese patients with type 2 diabetes.
Topics: Administration, Oral; Adult; Alleles; Asian People; Blood Glucose; Carbamates; China; Diabetes Mellitus, Type 2; Female; Follow-Up Studies; Homeostasis; Humans; Hypoglycemic Agents; Insulin; Insulin Resistance; KCNQ1 Potassium Channel; Male; Middle Aged; Pharmacogenetics; Piperidines; Polymorphism, Single Nucleotide; Rosiglitazone; Thiazolidinediones | 2011 |
Effect of repaglinide and gliclazide on glycaemic control, early-phase insulin secretion and lipid profiles in.
Topics: Adult; Blood Glucose; Carbamates; Cholesterol; Diabetes Mellitus, Type 2; Fasting; Female; Gliclazide; Humans; Hypoglycemic Agents; Insulin; Insulin Secretion; Male; Middle Aged; Piperidines; Postprandial Period; Treatment Outcome; Triglycerides | 2011 |
Mechanism-based inactivation of CYP2C8 by gemfibrozil occurs rapidly in humans.
Topics: Adult; Area Under Curve; Aryl Hydrocarbon Hydroxylases; Carbamates; Cross-Over Studies; Cytochrome P-450 CYP2C8; Female; Gemfibrozil; Glucuronates; Humans; Hypoglycemic Agents; Male; Piperidines; Time Factors | 2011 |
Dose-dependent interaction between gemfibrozil and repaglinide in humans: strong inhibition of CYP2C8 with subtherapeutic gemfibrozil doses.
Topics: Adult; Area Under Curve; Aryl Hydrocarbon Hydroxylases; Blood Glucose; Carbamates; Cross-Over Studies; Cytochrome P-450 CYP2C8; Dose-Response Relationship, Drug; Double-Blind Method; Drug Interactions; Female; Gemfibrozil; Genotype; Humans; Male; Organic Anion Transporters; Piperidines; Young Adult | 2011 |
Randomized study of repaglinide alone and in combination with metformin in Chinese subjects with type 2 diabetes naive to oral antidiabetes therapy.
Topics: Adolescent; Adult; Aged; Blood Glucose; Carbamates; China; Diabetes Mellitus, Type 2; Drug Therapy, Combination; Female; Glycated Hemoglobin; Humans; Hypoglycemic Agents; Male; Metformin; Middle Aged; Piperidines; Young Adult | 2011 |
The pregnane X receptor agonist St John's Wort has no effects on the pharmacokinetics and pharmacodynamics of repaglinide.
Topics: Carbamates; Cross-Over Studies; Cytochrome P-450 Enzyme System; Depression; Genotype; Herb-Drug Interactions; Humans; Hypericum; Hypoglycemic Agents; Liver-Specific Organic Anion Transporter 1; Organic Anion Transporters; Phytotherapy; Piperidines; Placebos; Plant Extracts; Pregnane X Receptor; Receptors, Steroid; Young Adult | 2011 |
Effects of short-term therapy with glibenclamide and repaglinide on incretin hormones and oxidative damage associated with postprandial hyperglycaemia in people with type 2 diabetes mellitus.
Topics: Adult; Aged; Analysis of Variance; Biomarkers; Blood Glucose; Carbamates; Diabetes Mellitus, Type 2; Drug Administration Schedule; Drug Therapy, Combination; E-Selectin; F2-Isoprostanes; Female; Gastric Inhibitory Polypeptide; Glucagon-Like Peptide 1; Glyburide; Glycated Hemoglobin; Humans; Hyperglycemia; Hypoglycemic Agents; Incretins; Insulin; Intercellular Adhesion Molecule-1; Interleukin-6; Male; Metformin; Middle Aged; Oxidative Stress; Piperidines; Postprandial Period; Time Factors; Treatment Outcome; Wales | 2011 |
NeuroD1 A45T and PAX4 R121W polymorphisms are associated with plasma glucose level of repaglinide monotherapy in Chinese patients with type 2 diabetes.
Topics: Adult; Aged; Alleles; Asian People; Basic Helix-Loop-Helix Transcription Factors; Blood Glucose; Carbamates; Case-Control Studies; China; Diabetes Mellitus, Type 2; Female; Genotype; Homeodomain Proteins; Humans; Hypoglycemic Agents; Male; Middle Aged; Paired Box Transcription Factors; Piperidines; Polymorphism, Genetic; Polymorphism, Restriction Fragment Length | 2012 |
Strict glycaemic control improves skin microcirculation in patients with type 2 diabetes: a report from the Diabetes mellitus And Diastolic Dysfunction (DADD) study.
Topics: Administration, Oral; Aged; Biomarkers; Blood Glucose; Brachial Artery; Carbamates; Diabetes Mellitus, Type 2; Diabetic Angiopathies; Diastole; Female; Glycated Hemoglobin; Humans; Hypoglycemic Agents; Insulin Aspart; Insulin Glargine; Insulin, Long-Acting; Laser-Doppler Flowmetry; Male; Metformin; Microcirculation; Middle Aged; Piperidines; Prospective Studies; Regional Blood Flow; Skin; Sweden; Time Factors; Treatment Outcome; Vasodilation; Ventricular Dysfunction; Ventricular Function | 2012 |
The Influence of MDR1 G2677T/a genetic polymorphisms on the pharmacokinetics of repaglinide in healthy Chinese volunteers.
Topics: Adult; Alleles; Area Under Curve; Aryl Hydrocarbon Hydroxylases; Asian People; ATP Binding Cassette Transporter, Subfamily B, Member 1; Carbamates; Cytochrome P-450 CYP2C8; Cytochrome P-450 CYP3A; Genotype; Haplotypes; Humans; Hypoglycemic Agents; Liver-Specific Organic Anion Transporter 1; Male; Organic Anion Transporters; Piperidines; Polymorphism, Single Nucleotide | 2012 |
KCNQ1 gene polymorphisms are associated with the therapeutic efficacy of repaglinide in Chinese type 2 diabetic patients.
Topics: Adult; Asian People; Carbamates; Diabetes Mellitus, Type 2; Female; Gene Frequency; Genotype; Humans; KCNQ1 Potassium Channel; Male; Middle Aged; Piperidines; Polymorphism, Genetic; Risk Factors; Treatment Outcome | 2012 |
Association of a SLC30A8 genetic variant with monotherapy of repaglinide and rosiglitazone effect in newly diagnosed type 2 diabetes patients in China.
Topics: Carbamates; Cation Transport Proteins; China; Diabetes Mellitus, Type 2; Female; Gene Frequency; Humans; Hypoglycemic Agents; Male; Middle Aged; Piperidines; Polymorphism, Single Nucleotide; Rosiglitazone; Thiazolidinediones; Zinc Transporter 8 | 2012 |
Gemfibrozil is a strong inactivator of CYP2C8 in very small multiple doses.
Topics: Area Under Curve; Aryl Hydrocarbon Hydroxylases; Blood Glucose; Carbamates; Cross-Over Studies; Cytochrome P-450 CYP2C8; Dose-Response Relationship, Drug; Enzyme Inhibitors; Gemfibrozil; Genotype; Glucuronides; Humans; Liver-Specific Organic Anion Transporter 1; Organic Anion Transporters; Piperidines | 2012 |
Lack of the QTc physiologic decrease during cardiac stress test in patients with type 2 diabetes treated with secretagogues.
Topics: Aged; Arrhythmias, Cardiac; Carbamates; Diabetes Mellitus, Type 2; Electrocardiography; Exercise Test; Female; Glyburide; Heart Rate; Humans; Hypoglycemic Agents; Male; Metformin; Middle Aged; Piperidines | 2014 |
Effect of pitavastatin in different SLCO1B1 backgrounds on repaglinide pharmacokinetics and pharmacodynamics in healthy Chinese males.
Topics: Area Under Curve; Asian People; Blood Glucose; Carbamates; Cross-Over Studies; Drug Interactions; Genotype; Homozygote; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypoglycemic Agents; Liver-Specific Organic Anion Transporter 1; Male; Organic Anion Transporters; Piperidines; Polymorphism, Single Nucleotide; Quinolines | 2013 |
PXR polymorphisms and their impact on pharmacokinetics/pharmacodynamics of repaglinide in healthy Chinese volunteers.
Topics: Anti-Bacterial Agents; Aryl Hydrocarbon Hydroxylases; Asian People; Blood Glucose; Carbamates; Cross-Over Studies; Cytochrome P-450 CYP2C8; Cytochrome P-450 CYP3A; Drug Interactions; Floxacillin; Genotype; Healthy Volunteers; Humans; Hypoglycemic Agents; Piperidines; Polymorphism, Single Nucleotide; Pregnane X Receptor; Receptors, Steroid | 2013 |
Effects of NOS1AP rs12742393 polymorphism on repaglinide response in Chinese patients with type 2 diabetes mellitus.
Topics: Adaptor Proteins, Signal Transducing; Adult; Alleles; Asian People; Blood Glucose; Carbamates; Case-Control Studies; Diabetes Mellitus, Type 2; Female; Gene Frequency; Genotype; Humans; Hypoglycemic Agents; Male; Middle Aged; Piperidines; Polymerase Chain Reaction; Polymorphism, Genetic; Polymorphism, Restriction Fragment Length; Prospective Studies | 2014 |
Open randomised prospective comparative multi-centre intervention study of patients with cystic fibrosis and early diagnosed diabetes mellitus.
Topics: Adolescent; Algorithms; Carbamates; Child; Cystic Fibrosis; Diabetes Mellitus; Early Diagnosis; Humans; Hypoglycemic Agents; Insulin; Piperidines; Prospective Studies | 2014 |
Comparison of repaglinide and metformin monotherapy as an initial therapy in Chinese patients with newly diagnosed type 2 diabetes mellitus.
Topics: Adult; Aged; Aged, 80 and over; Blood Glucose; Carbamates; Diabetes Mellitus, Type 2; Dose-Response Relationship, Drug; Female; Humans; Hypoglycemic Agents; Male; Metformin; Middle Aged; Piperidines; Young Adult | 2014 |
Comparison of metformin and repaglinide monotherapy in the treatment of new onset type 2 diabetes mellitus in China.
Topics: Body Mass Index; Carbamates; China; Combined Modality Therapy; Diabetes Mellitus, Type 2; Diet, Diabetic; Diet, Reducing; Drug Monitoring; Female; Glycated Hemoglobin; Humans; Hyperglycemia; Hyperlipidemias; Hypoglycemic Agents; Insulin; Insulin Resistance; Insulin Secretion; Insulin-Secreting Cells; Male; Metformin; Middle Aged; Overweight; Piperidines; Weight Loss | 2014 |
Glucuronidation converts clopidogrel to a strong time-dependent inhibitor of CYP2C8: a phase II metabolite as a perpetrator of drug-drug interactions.
Topics: Aryl Hydrocarbon Hydroxylases; Carbamates; Catalytic Domain; Clopidogrel; Computer Simulation; Cytochrome P-450 CYP2C8; Cytochrome P-450 CYP3A; Drug Interactions; Female; Glucuronides; Humans; Hypoglycemic Agents; Male; Metabolic Detoxication, Phase II; Molecular Docking Simulation; Piperidines; Platelet Aggregation Inhibitors; Ticlopidine; Time Factors | 2014 |
Effect of repaglinide, administered two or three times daily for 3 months, on glycaemic control in Japanese patients with type 2 diabetes mellitus.
Topics: Administration, Oral; Adult; Blood Glucose; Carbamates; Diabetes Mellitus, Type 2; Drug Administration Schedule; Female; Follow-Up Studies; Glycated Hemoglobin; Glycemic Index; Humans; Hypoglycemic Agents; Japan; Male; Middle Aged; Piperidines; Prognosis | 2014 |
PPARD rs2016520 polymorphism affects repaglinide response in Chinese Han patients with type 2 diabetes mellitus.
Topics: Adult; Asian People; Carbamates; Diabetes Mellitus, Type 2; Female; Humans; Hypoglycemic Agents; Insulin; Male; Middle Aged; Piperidines; Polymorphism, Genetic; Postprandial Period; PPAR delta; Treatment Outcome | 2015 |
Bilayer matrix tablets for prolonged actions of metformin hydrochloride and repaglinide.
Topics: Animals; Carbamates; Chemistry, Pharmaceutical; Cross-Over Studies; Delayed-Action Preparations; Dogs; Drug Combinations; Male; Metformin; Piperidines; Tablets | 2015 |
Physiologically based pharmacokinetics model predicts the lack of inhibition by repaglinide on the metabolism of pioglitazone.
Topics: Adolescent; Adult; Algorithms; Biotransformation; Carbamates; Chemical Phenomena; Computational Biology; Cross-Over Studies; Drug Interactions; Expert Systems; Half-Life; Humans; Hypoglycemic Agents; Metabolic Clearance Rate; Microsomes, Liver; Middle Aged; Models, Biological; Pioglitazone; Piperidines; Software; Thiazolidinediones; Young Adult | 2015 |
Pharmacokinetic Effects of Isavuconazole Coadministration With the Cytochrome P450 Enzyme Substrates Bupropion, Repaglinide, Caffeine, Dextromethorphan, and Methadone in Healthy Subjects.
Topics: Adult; Area Under Curve; Bupropion; Caffeine; Carbamates; Cytochrome P-450 Enzyme System; Dextromethorphan; Drug Interactions; Female; Healthy Volunteers; Humans; Male; Methadone; Middle Aged; Nitriles; Piperidines; Pyridines; Triazoles; Young Adult | 2017 |
Effect of Switching from Sulphonylurea to Repaglinide Twice or Three Times Daily for 4 Months on Glycemic Control in Japanese Patients with Type 2 Diabetes.
Topics: Aged; Blood Glucose; Carbamates; Diabetes Mellitus, Type 2; Drug Administration Schedule; Female; Glycated Hemoglobin; Glycated Serum Albumin; Glycation End Products, Advanced; Humans; Hypoglycemic Agents; Japan; Male; Middle Aged; Piperidines; Serum Albumin; Sulfonylurea Compounds | 2016 |
Efficacy and safety of repaglinide added to sitagliptin in Japanese patients with type 2 diabetes: A randomized 24-week open-label clinical trial.
Topics: Aged; Blood Glucose; Carbamates; Diabetes Mellitus, Type 2; Drug Substitution; Drug Therapy, Combination; Female; Glycated Hemoglobin; Humans; Hypoglycemic Agents; Insulin; Insulin Secretion; Male; Middle Aged; Piperidines; Postprandial Period; Sitagliptin Phosphate; Treatment Outcome | 2016 |
A variation in KCNQ1 gene is associated with repaglinide efficacy on insulin resistance in Chinese Type 2 Diabetes Mellitus Patients.
Topics: Adult; Asian People; Carbamates; China; Diabetes Mellitus, Type 2; Female; Hep G2 Cells; Humans; Insulin Receptor Substrate Proteins; Insulin Resistance; KCNQ1 Potassium Channel; Male; Middle Aged; Phosphatidylinositol 3-Kinases; Piperidines; Polymorphism, Genetic; Proto-Oncogene Proteins c-akt; Signal Transduction | 2016 |
Efficacy and safety of metformin and sitagliptin based triple antihyperglycemic therapy (STRATEGY): a multicenter, randomized, controlled, non-inferiority clinical trial.
Topics: Acarbose; Adult; Blood Glucose; Carbamates; Diabetes Mellitus, Type 2; Drug Therapy, Combination; Female; Gliclazide; Glycated Hemoglobin; Humans; Hypoglycemic Agents; Male; Metformin; Middle Aged; Piperidines; Sitagliptin Phosphate; Sulfonylurea Compounds; Treatment Outcome | 2017 |
Repaglinide versus insulin for newly diagnosed diabetes in patients with cystic fibrosis: a multicentre, open-label, randomised trial.
Topics: Adolescent; Adult; Biomarkers; Blood Glucose; Carbamates; Child; Cystic Fibrosis; Diabetes Mellitus, Type 2; Female; Follow-Up Studies; Glycated Hemoglobin; Humans; Hypoglycemic Agents; Insulin; Male; Piperidines; Prognosis; Young Adult | 2018 |
Bioequivalence of a fixed-dose repaglinide/metformin combination tablet and equivalent doses of repaglinide and metformin tablets
.
Topics: Adult; Carbamates; Cross-Over Studies; Drug Combinations; Drug Therapy, Combination; Humans; Male; Metformin; Piperidines; Tablets; Therapeutic Equivalency | 2018 |
A variant of GRK5 is associated with the therapeutic efficacy of repaglinide in Chinese Han patients with type 2 diabetes mellitus.
Topics: Asian People; Blood Glucose; Carbamates; Cytochrome P-450 CYP2C8; Diabetes Mellitus, Type 2; Female; G-Protein-Coupled Receptor Kinase 5; Genotype; Humans; Hypoglycemic Agents; Insulin; Liver-Specific Organic Anion Transporter 1; Male; Middle Aged; Piperidines; Polymorphism, Genetic; Treatment Outcome | 2018 |
Reduction in glucose fluctuations in elderly patients with type 2 diabetes using repaglinide: A randomized controlled trial of repaglinide vs sulfonylurea.
Topics: Aged; Aged, 80 and over; Biomarkers; Blood Glucose; Carbamates; Diabetes Mellitus, Type 2; Female; Follow-Up Studies; Glycated Hemoglobin; Humans; Hyperglycemia; Hypoglycemia; Hypoglycemic Agents; Male; Middle Aged; Piperidines; Prognosis; Prospective Studies; Sulfonylurea Compounds | 2019 |
Effects of rolapitant administered orally on the pharmacokinetics of dextromethorphan (CYP2D6), tolbutamide (CYP2C9), omeprazole (CYP2C19), efavirenz (CYP2B6), and repaglinide (CYP2C8) in healthy subjects.
Topics: Administration, Oral; Adolescent; Adult; Alkynes; Antiemetics; Benzoxazines; Carbamates; Cyclopropanes; Cytochrome P-450 CYP2B6; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP2C8; Cytochrome P-450 CYP2C9; Cytochrome P-450 CYP2D6; Dextromethorphan; Drug Combinations; Drug Interactions; Female; Healthy Volunteers; Humans; Male; Middle Aged; Molecular Probes; Neurokinin-1 Receptor Antagonists; Omeprazole; Piperidines; Spiro Compounds; Tolbutamide; Young Adult | 2019 |
Characteristics of repaglinide and its mechanism of action on insulin secretion in patients with newly diagnosed type-2 diabetes mellitus.
Topics: Actins; Adult; Aged; Aged, 80 and over; Antigens; Blood Glucose; Carbamates; Diabetes Mellitus, Type 2; Female; Glucose Tolerance Test; Glycated Hemoglobin; Humans; Hypoglycemic Agents; Insulin; Insulin Secretion; Male; Middle Aged; Piperidines; Treatment Outcome; Young Adult | 2018 |
Assessment of CYP-Mediated Drug Interactions for Evocalcet, a New Calcimimetic Agent, Based on In Vitro Investigations and a Cocktail Study in Humans.
Topics: Administration, Oral; Adult; Alkynes; Benzoxazines; Calcimimetic Agents; Carbamates; Cells, Cultured; Cyclopropanes; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Drug Interactions; Healthy Volunteers; Hepatocytes; Humans; Hyperparathyroidism, Secondary; Inhibitory Concentration 50; Isoenzymes; Male; Naphthalenes; Oxidation-Reduction; Piperidines; Primary Cell Culture; Pyrrolidines; Theophylline; Young Adult | 2019 |
Comparison of the Efficacy of Repaglinide Versus the Combination of Mitiglinide and Voglibose on Glycemic Variability in Japanese Patients with Type 2 Diabetes.
Topics: Blood Glucose; Blood Glucose Self-Monitoring; Carbamates; Cross-Over Studies; Diabetes Mellitus, Type 2; Humans; Hypoglycemic Agents; Inositol; Isoindoles; Japan; Piperidines | 2020 |
Results from Drug-Drug Interaction Studies In Vitro and In Vivo Investigating the Effect of Finerenone on the Pharmacokinetics of Comedications.
Topics: Administration, Oral; Adolescent; Adult; Carbamates; Cross-Over Studies; Cytochrome P-450 CYP2C8; Cytochrome P-450 CYP2C9; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inducers; Cytochrome P-450 Enzyme Inhibitors; Double-Blind Method; Drug Interactions; Germany; Humans; Isoenzymes; Male; Midazolam; Middle Aged; Mineralocorticoid Receptor Antagonists; Models, Biological; Naphthyridines; Piperidines; Substrate Specificity; Warfarin; Young Adult | 2020 |
A time to revisit the two oldest prandial anti-diabetes agents: acarbose and repaglinide.
Topics: Acarbose; Blood Glucose; Carbamates; Diabetes Mellitus, Type 2; Glycated Hemoglobin; Humans; Hypoglycemic Agents; Insulin; Piperidines; Prospective Studies | 2020 |
Pharmacokinetic drug interactions of asciminib with the sensitive cytochrome P450 probe substrates midazolam, warfarin, and repaglinide in healthy participants.
Topics: Carbamates; Cytochrome P-450 CYP2C8; Cytochrome P-450 CYP2C9; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Drug Interactions; Healthy Volunteers; Humans; Midazolam; Niacinamide; Piperidines; Pyrazoles; Warfarin | 2022 |
309 other study(ies) available for carbamates and repaglinide
| Article | Year |
|---|---|
Quantitation of the new hypoglycaemic agent AG-EE 388 ZW in human plasma by automated high-performance liquid chromatography with electrochemical detection.
Topics: Administration, Oral; Carbamates; Chromatography, High Pressure Liquid; Electrochemistry; Humans; Hypoglycemic Agents; Injections, Intravenous; Piperidines | 1991 |
Ionophoretic activity of meglitinide analogues.
Topics: Benzamides; Biological Transport; Calcium; Carbamates; Hypoglycemic Agents; Indoles; Insulin; Insulin Secretion; Ionophores; Isoindoles; Membranes, Artificial; Models, Biological; Piperidines; Sodium; Structure-Activity Relationship | 1994 |
Insulinotropic action of meglitinide analogs: concentration-response relationship and nutrient dependency.
Topics: Animals; Benzamides; Carbamates; Cyclohexanes; Female; Glucose; Hypoglycemic Agents; In Vitro Techniques; Indoles; Insulin; Insulin Secretion; Islets of Langerhans; Isoindoles; Molecular Structure; Nateglinide; Phenylalanine; Piperidines; Rats; Structure-Activity Relationship; Succinates | 1994 |
Effects of the hypoglycaemic drugs repaglinide and glibenclamide on ATP-sensitive potassium-channels and cytosolic calcium levels in beta TC3 cells and rat pancreatic beta cells.
Topics: Adenosine Triphosphate; Animals; Animals, Newborn; Calcium; Carbamates; Cell Line; Cells, Cultured; Cytosol; Dose-Response Relationship, Drug; Glyburide; Hypoglycemic Agents; Ion Channel Gating; Islets of Langerhans; Kinetics; Membrane Potentials; Mice; Patch-Clamp Techniques; Piperidines; Potassium Channels; Rats; Serum Albumin; Time Factors; Verapamil | 1995 |
Conformational analysis of non-sulfonylurea hypoglycemic agents of the meglitinide family.
Topics: Benzamides; Carbamates; Cyclohexanes; Drug Design; Glyburide; Hypoglycemic Agents; Indoles; Isoindoles; Molecular Conformation; Nateglinide; Phenylalanine; Piperidines; Stereoisomerism; Structure-Activity Relationship; Sulfonylurea Compounds | 1995 |
Insulinotropic action of meglitinide analogues: modulation by an activator of ATP-sensitive K+ channels and high extracellular K+ concentrations.
Topics: Animals; Benzamides; Carbamates; Cyclohexanes; Female; Hypoglycemic Agents; Indoles; Insulin; Insulin Secretion; Islets of Langerhans; Isoindoles; Nateglinide; Phenylalanine; Piperidines; Potassium; Rats | 1995 |
Effects of the methyl esters of pyruvate, succinate and glutamate on the secretory response to meglitinide analogues in rat pancreatic islets.
Topics: Animals; Carbamates; Cells, Cultured; Cyclohexanes; Glucose; Glutamates; Hypoglycemic Agents; Indoles; Insulin; Insulin Secretion; Islets of Langerhans; Isoindoles; Nateglinide; Phenylalanine; Piperidines; Pyruvates; Rats; Succinates | 1996 |
Hypoglycaemic effects of the novel antidiabetic agent repaglinide in rats and dogs.
Topics: Animals; Carbamates; Dogs; Female; Glyburide; Hypoglycemic Agents; Piperidines; Rats; Rats, Wistar; Stereoisomerism; Sulfonylurea Compounds | 1997 |
Repaglinide, glibenclamide and glimepiride administration to normal and hereditarily diabetic rats.
Topics: Administration, Oral; Animals; Blood Glucose; Carbamates; Diabetes Mellitus, Type 2; Fasting; Female; Glyburide; Hypoglycemic Agents; Insulin; Male; Piperidines; Rats; Rats, Wistar; Sulfonylurea Compounds | 1997 |
Stimulation of insulin release and potentiation of the insulinotropic action of antidiabetic agents by 1,2,3-tri(methylsuccinyl)glycerol ester in anaesthetized rats.
Topics: Animals; Blood Glucose; Carbamates; Drug Synergism; Esters; Hypoglycemic Agents; Insulin; Male; Piperidines; Rats; Rats, Wistar; Stereoisomerism; Succinates; Sulfonylurea Compounds | 1997 |
Effect of antidiabetic agents on the increase in glycemia and insulinemia caused by refeeding in hereditarily diabetic rats.
Topics: Animals; Blood Glucose; Carbamates; Diabetes Mellitus, Experimental; Food; Glyburide; Hypoglycemic Agents; Insulin; Male; Piperidines; Rats; Starvation | 1997 |
Stimulation of insulin release by repaglinide and glibenclamide involves both common and distinct processes.
Topics: Animals; Binding Sites; Binding, Competitive; Blood Glucose; Carbamates; Cohort Studies; Culture Techniques; Diabetes Mellitus, Type 2; Dose-Response Relationship, Drug; Evoked Potentials; Glucose; Glyburide; Hypoglycemic Agents; Insulin; Insulin Secretion; Islets of Langerhans; Male; Mice; Mice, Inbred Strains; Osmolar Concentration; Patch-Clamp Techniques; Perfusion; Piperidines; Rats; Rats, Sprague-Dawley; Time Factors; Tritium | 1998 |
Effect of repaglinide upon nutrient metabolism, biosynthetic activity, cationic fluxes and insulin release in rat pancreatic islets.
Topics: Animals; Calcium Radioisotopes; Carbamates; Cations; Female; Glucose; Glutamine; Hypoglycemic Agents; Insulin; Islets of Langerhans; Palmitic Acid; Piperidines; Rats; Rats, Wistar; Rubidium Radioisotopes | 1998 |
Repaglinide for type 2 diabetes mellitus.
Topics: Carbamates; Clinical Trials as Topic; Diabetes Mellitus, Type 2; Dose-Response Relationship, Drug; Fasting; Humans; Hypoglycemic Agents; Piperidines; Postprandial Period | 1998 |
Pancreatic islet responsiveness to D-glucose after repeated administration of repaglinide.
Topics: Administration, Oral; Animals; Blood Glucose; Carbamates; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Female; Glucose; Hypoglycemic Agents; Insulin; Islets of Langerhans; Piperidines; Rats; Rats, Wistar | 1998 |
Stimulation of insulin and somatostatin release by two meglitinide analogs.
Topics: Animals; Benzamides; Blood Glucose; Carbamates; Cyclohexanes; Female; Glucagon; Hypoglycemic Agents; Insulin; Insulin Secretion; Islets of Langerhans; Nateglinide; Perfusion; Phenylalanine; Piperidines; Rats; Rats, Wistar; Somatostatin | 1997 |
Drug knowledge is critical.
Topics: Aged; Carbamates; Diabetes Mellitus, Type 2; Drug Interactions; Humans; Hypoglycemia; Hypoglycemic Agents; Male; Piperidines | 1998 |
For diabetes: a preprandial pill ...
Topics: Carbamates; Diabetes Mellitus, Type 2; Humans; Hypoglycemic Agents; Piperidines | 1998 |
Effect of repaglinide on insulin secretion in islets from rats infused for two days with a hypertonic solution of D-glucose.
Topics: Animals; Benzamides; Blood Glucose; Carbamates; Female; Glucose Solution, Hypertonic; Hypoglycemic Agents; Insulin; Insulin Secretion; Islets of Langerhans; Piperidines; Rats; Rats, Wistar; Stereoisomerism | 1998 |
Repaglinide and related hypoglycemic benzoic acid derivatives.
Topics: Administration, Oral; Animals; ATP-Binding Cassette Transporters; Benzoates; Blood Glucose; Carbamates; Crystallography, X-Ray; Female; Glyburide; Hypoglycemic Agents; Models, Molecular; Molecular Conformation; Piperidines; Potassium Channels; Potassium Channels, Inwardly Rectifying; Rats; Rats, Wistar; Receptors, Drug; Stereoisomerism; Structure-Activity Relationship; Sulfonylurea Compounds; Sulfonylurea Receptors | 1998 |
[Flexible oral therapy of diabetes mellitus type 2: dietary glucose regulation as therapeutic principle. 34th annual session of the European Association for the Study of Diabetes (EASD). Barcelona, 8-12 September 1998].
Topics: Administration, Oral; Blood Glucose; Carbamates; Diabetes Mellitus, Type 2; Diet, Diabetic; Glucose; Humans; Hypoglycemic Agents; Insulin; Insulin Secretion; Piperidines | 1998 |
Pharmacokinetic profiles of repaglinide in elderly subjects with type 2 diabetes.
Topics: Aged; Carbamates; Diabetes Mellitus, Type 2; Female; Humans; Hypoglycemic Agents; Male; Piperidines | 1999 |
Inhibition of heterologously expressed cystic fibrosis transmembrane conductance regulator Cl- channels by non-sulphonylurea hypoglycaemic agents.
Topics: Adenosine Triphosphate; Animals; Benzamides; Carbamates; Cell Line; Chloride Channels; Cyclic AMP-Dependent Protein Kinases; Cystic Fibrosis Transmembrane Conductance Regulator; Electric Conductivity; Epithelial Cells; Glyburide; Humans; Hypoglycemic Agents; Indoles; Ion Channel Gating; Isoindoles; Kinetics; Mice; Patch-Clamp Techniques; Piperidines; Sulfonylurea Compounds; Transfection | 1999 |
Tissue selectivity of antidiabetic agent nateglinide: study on cardiovascular and beta-cell K(ATP) channels.
Topics: Animals; Aorta, Thoracic; Carbamates; Cardiovascular System; Coronary Vessels; Cyclohexanes; Glyburide; Heart; Hypoglycemic Agents; Islets of Langerhans; Male; Muscle, Smooth, Vascular; Nateglinide; Phenylalanine; Piperidines; Potassium Channels; Potassium Channels, Inwardly Rectifying; Rats; Rats, Sprague-Dawley; Swine | 1999 |
Selectivity of prandial glucose regulators: nateglinide, but not repaglinide, accelerates exocytosis in rat pancreatic A-cells.
Topics: Animals; ATP-Binding Cassette Transporters; Calcium; Carbamates; Cyclohexanes; Eating; Electrophysiology; Exocytosis; Glucagon; Glucose; Hypoglycemic Agents; In Vitro Techniques; Islets of Langerhans; KATP Channels; Kinetics; Male; Nateglinide; Patch-Clamp Techniques; Phenylalanine; Piperidines; Potassium Channel Blockers; Potassium Channels; Potassium Channels, Inwardly Rectifying; Rats; Rats, Inbred Lew; Stimulation, Chemical | 1999 |
Improving management of type 2 diabetes mellitus: 4. Meglitinides.
Topics: Carbamates; Contraindications; Diabetes Mellitus, Type 2; Humans; Hypoglycemic Agents; Piperidines | 1999 |
Comments on type 2 diabetes screening and treatment.
Topics: Carbamates; Diabetes Mellitus, Type 2; Dose-Response Relationship, Drug; Drug Administration Schedule; Humans; Hypoglycemic Agents; Piperidines | 2000 |
Pharmacologic management of diabetes mellitus.
Topics: Carbamates; Chromans; Diabetes Mellitus; Humans; Hypoglycemic Agents; Metformin; Piperidines; Sulfonylurea Compounds; Thiazoles; Thiazolidinediones; Troglitazone | 1999 |
Drug interaction studies with repaglinide: repaglinide on digoxin or theophylline pharmacokinetics and cimetidine on repaglinide pharmacokinetics.
Topics: Adolescent; Adult; Carbamates; Cimetidine; Cross-Over Studies; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Digoxin; Drug Interactions; Female; Humans; Hypoglycemic Agents; Male; Middle Aged; Mixed Function Oxygenases; Piperidines; Theophylline | 2000 |
Managing type 2 diabetes. A look at the newer agents.
Topics: Acarbose; Carbamates; Chromans; Diabetes Mellitus, Type 2; Humans; Hypoglycemic Agents; Metformin; Piperidines; Thiazoles; Thiazolidinediones; Troglitazone | 1999 |
[Mechanisms of action of repaglinide at a cellular level].
Topics: Carbamates; Diabetes Mellitus, Type 2; Humans; Hyperglycemia; Hypoglycemic Agents; Inulin; Piperidines | 1999 |
[Insulin secretion and repaglinide].
Topics: Carbamates; Diabetes Mellitus, Type 2; Diabetic Angiopathies; Diet, Diabetic; Exercise; Humans; Hypoglycemic Agents; Insulin; Insulin Secretion; Piperidines | 1999 |
[Repaglinide in combination therapy in type 2 diabetes].
Topics: Carbamates; Diabetes Mellitus, Type 2; Drug Therapy, Combination; Humans; Hypoglycemic Agents; Insulin; Insulin Secretion; Islets of Langerhans; Metformin; Piperidines | 1999 |
Repaglinide: a novel oral antidiabetic agent.
Topics: Administration, Oral; Blood Glucose; Body Weight; Carbamates; Diabetes Mellitus, Type 2; Humans; Hypoglycemia; Hypoglycemic Agents; Piperidines; Sulfonylurea Compounds | 2000 |
Pancreatic beta-cell K(ATP) channel activity and membrane-binding studies with nateglinide: A comparison with sulfonylureas and repaglinide.
Topics: Animals; ATP-Binding Cassette Transporters; Binding, Competitive; Carbamates; Cell Membrane; Cell Separation; Cells, Cultured; Cyclohexanes; Glucose; Glyburide; Glycosyltransferases; Humans; Hypoglycemia; Hypoglycemic Agents; In Vitro Techniques; Insulin; Islets of Langerhans; KATP Channels; Kinetics; Male; Membrane Proteins; Nateglinide; Patch-Clamp Techniques; Phenylalanine; Piperidines; Potassium Channel Blockers; Potassium Channels; Potassium Channels, Inwardly Rectifying; Rats; Rats, Sprague-Dawley; Repressor Proteins; Saccharomyces cerevisiae Proteins; Sulfonylurea Compounds | 2000 |
Effects of the oral antidiabetic repaglinide on the reproduction of rats.
Topics: Animals; Bone Development; Carbamates; Embryo Implantation; Embryonic and Fetal Development; Female; Fertility; Growth; Humans; Hypoglycemic Agents; Labor, Obstetric; Piperidines; Pregnancy; Rats; Rats, Wistar; Reproduction; Teratogens | 2000 |
The effects of selected drugs on the in vitro protein binding of repaglinide in human plasma.
Topics: Adsorption; Blood Proteins; Carbamates; Drug Interactions; Humans; Hypoglycemic Agents; Orosomucoid; Piperidines; Protein Binding; Serum Albumin | 2000 |
[Prandial glucose regulator for type 2 diabetic patients. Beta cells produce insulin according to need].
Topics: Blood Glucose; Carbamates; Diabetes Mellitus, Type 2; Humans; Hypoglycemic Agents; Insulin; Islets of Langerhans; Piperidines | 1999 |
[Antidiabetic drug at every meal. Repaglinide is especially recommended for slender type 2 diabetic patients].
Topics: Blood Glucose; Carbamates; Diabetes Mellitus; Diabetes Mellitus, Type 2; Dose-Response Relationship, Drug; Drug Administration Schedule; Humans; Hypoglycemic Agents; Obesity; Piperidines | 2000 |
Prandial glucose regulation with repaglinide: its clinical and lifestyle impact in a large cohort of patients with Type 2 diabetes.
Topics: Attitude to Health; Blood Glucose; Carbamates; Cohort Studies; Diabetes Mellitus, Type 2; Drug Therapy, Combination; Eating; Feeding Behavior; Female; Germany; Humans; Hypoglycemic Agents; Life Style; Male; Middle Aged; Piperidines; Professional Practice; Prospective Studies; Surveys and Questionnaires; Treatment Outcome; Weight Loss | 2000 |
Repaglinide-induced factitious hypoglycemia.
Topics: Adolescent; Blood Glucose; Carbamates; Diagnosis, Differential; Fasting; Humans; Hypoglycemia; Hypoglycemic Agents; Insulin; Insulin Secretion; Male; Mental Disorders; Piperidines; Poisoning | 2001 |
Honing type 2 diabetes treatment.
Topics: Carbamates; Diabetes Mellitus, Type 2; Humans; Hypoglycemic Agents; Pioglitazone; Piperidines; Thiazoles; Thiazolidinediones | 2001 |
Insulin secretagogues.
Topics: Blood Glucose; Carbamates; Diabetes Mellitus, Type 2; Humans; Hypoglycemic Agents; Insulin Resistance; Piperidines | 1997 |
[Large general practice study with repaglinide. Fewer "anxiety eating" in diabetic patients].
Topics: Carbamates; Diabetes Mellitus, Type 2; Diet, Diabetic; Feeding Behavior; Humans; Hypoglycemic Agents; Patient Compliance; Piperidines | 2001 |
Differential effects of short and long duration insulinotropic agents on meal-related glucose excursions.
Topics: Animals; Blood Glucose; Carbamates; Cyclohexanes; Food; Glipizide; Glucagon; Insulin; Insulin Secretion; Male; Nateglinide; Phenylalanine; Piperidines; Rats; Rats, Sprague-Dawley | 2001 |
[Repaglinide].
Topics: Carbamates; Diabetes Mellitus, Type 2; Half-Life; Humans; Hypoglycemic Agents; Insulin; Piperidines; Structure-Activity Relationship | 2001 |
Effect of repaglinide on cloned beta cell, cardiac and smooth muscle types of ATP-sensitive potassium channels.
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Animals; ATP-Binding Cassette Transporters; Carbamates; Cell Line; Cloning, Molecular; Drug Synergism; Electric Conductivity; Female; Humans; Islets of Langerhans; Mice; Muscle, Smooth; Myocardium; Oocytes; Piperidines; Potassium Channel Blockers; Potassium Channels; Potassium Channels, Inwardly Rectifying; Rats; Receptors, Drug; Sulfonylurea Receptors; Xenopus laevis | 2001 |
A new era in type 2 diabetes mellitus treatment?
Topics: 1-Deoxynojirimycin; Acarbose; Carbamates; Diabetes Mellitus, Type 2; Glucosamine; Humans; Hypoglycemic Agents; Imino Pyranoses; Multicenter Studies as Topic; Pioglitazone; Piperidines; Randomized Controlled Trials as Topic; Thiazoles; Thiazolidinediones | 2001 |
Repaglinide dose response? A clinician's viewpoint.
Topics: Blood Glucose; C-Peptide; Carbamates; Diabetes Mellitus, Type 2; Dose-Response Relationship, Drug; Humans; Hypoglycemic Agents; Insulin; Piperidines | 2000 |
Utilization of oral hypoglycemic agents in a drug-insured U.S. population.
Topics: Carbamates; Chromans; Cohort Studies; Databases as Topic; Diabetes Mellitus, Type 2; Enzyme Inhibitors; Glycoside Hydrolase Inhibitors; Humans; Hypoglycemic Agents; Insurance, Pharmaceutical Services; Longitudinal Studies; Managed Care Programs; Metformin; Piperidines; Retrospective Studies; Sulfonylurea Compounds; Thiazoles; Thiazolidinediones; Time Factors; Troglitazone; United States | 2001 |
Repaglinide dose response? A clinician's viewpoint.
Topics: Blood Glucose; Carbamates; Diabetes Mellitus, Type 2; Dose-Response Relationship, Drug; Exercise; Humans; Hyperglycemia; Hypoglycemic Agents; Piperidines; Weight Loss | 1999 |
The importance of rapid insulin secretion: revisited.
Topics: Blood Glucose; Carbamates; Diabetes Mellitus, Type 2; Homeostasis; Humans; Hypoglycemic Agents; Insulin; Insulin Secretion; Piperidines | 1999 |
[Pharma-clinics. Medication of the month. Repaglinide (NovoNorm)].
Topics: Administration, Oral; Carbamates; Diabetes Mellitus, Type 2; Dose-Response Relationship, Drug; Humans; Hypoglycemic Agents; Piperidines; Postprandial Period | 2001 |
Effect of insulinotropic agent nateglinide on Kv and Ca(2+) channels in pancreatic beta-cell.
Topics: Animals; Calcium Channels; Carbamates; Cyclohexanes; Dose-Response Relationship, Drug; Electric Stimulation; Glyburide; Hypoglycemic Agents; Insulin; Insulin Secretion; Islets of Langerhans; Male; Membrane Potentials; Nateglinide; Patch-Clamp Techniques; Phenylalanine; Piperidines; Potassium Channels; Rats; Rats, Sprague-Dawley | 2001 |
Insulin and glucose excursion following premeal insulin lispro or repaglinide in cystic fibrosis-related diabetes.
Topics: Adult; Blood Glucose; Carbamates; Cystic Fibrosis; Diabetes Mellitus; Female; Food; Humans; Hypoglycemia; Hypoglycemic Agents; Insulin; Insulin Lispro; Male; Piperidines | 2001 |
Effect of repaglinide addition to NPH insulin monotherapy on glycemic control in patients with type 2 diabetes.
Topics: Aged; Blood Glucose; Carbamates; Diabetes Mellitus, Type 2; Drug Therapy, Combination; Female; Humans; Hypoglycemic Agents; Insulin, Isophane; Male; Middle Aged; Piperidines | 2001 |
[Therapy of type 2 diabetes. Avoiding postprandial blood glucose peaks!].
Topics: Blood Glucose; Carbamates; Diabetes Mellitus, Type 2; Drug Administration Schedule; Humans; Piperidines; Postprandial Period | 2001 |
Type 2 diabetes management.
Topics: Carbamates; Cyclohexanes; Diabetes Mellitus, Type 2; Drug Therapy, Combination; Humans; Hypoglycemic Agents; Metformin; Nateglinide; Phenylalanine; Piperidines | 2002 |
Subclinical type 1 diabetes.
Topics: Adult; Blood Glucose; Carbamates; Diabetes Mellitus, Type 1; Female; Glucose Tolerance Test; Humans; Hypoglycemic Agents; Infectious Mononucleosis; Piperidines; Postprandial Period | 2002 |
Insulinotropic meglitinide analogues.
Topics: Carbamates; Humans; Hyperglycemia; Hypoglycemic Agents; Piperidines | 2002 |
Interaction of nateglinide with K(ATP) channel in beta-cells underlies its unique insulinotropic action.
Topics: Adenosine Triphosphate; Animals; Carbamates; Cyclohexanes; Dose-Response Relationship, Drug; Glucose; Glyburide; Hypoglycemic Agents; Insulin; Insulin Secretion; Islets of Langerhans; Kinetics; Male; Membrane Potentials; Nateglinide; Phenylalanine; Piperidines; Potassium Channel Blockers; Potassium Channels; Rats; Rats, Sprague-Dawley; Sulfonylurea Compounds; Time Factors | 2002 |
Nateglinide, but not repaglinide, stimulates growth hormone release in rat pituitary cells by inhibition of K channels and stimulation of cyclic AMP-dependent exocytosis.
Topics: Animals; Calcium; Carbamates; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Cyclohexanes; Delayed Rectifier Potassium Channels; Exocytosis; Growth Hormone; Growth Hormone-Releasing Hormone; Hypoglycemic Agents; Male; Membrane Potentials; Nateglinide; Patch-Clamp Techniques; Phenylalanine; Piperidines; Pituitary Gland; Potassium; Potassium Channel Blockers; Potassium Channels; Potassium Channels, Voltage-Gated; Rats; Rats, Sprague-Dawley | 2002 |
Differential interactions of nateglinide and repaglinide on the human beta-cell sulphonylurea receptor 1.
Topics: ATP-Binding Cassette Transporters; Binding, Competitive; Carbamates; Cell Line; Cyclohexanes; Drug Interactions; Electrophysiology; Humans; Islets of Langerhans; Nateglinide; Phenylalanine; Piperidines; Potassium Channels; Potassium Channels, Inwardly Rectifying; Receptors, Drug; Sulfonylurea Receptors; Tolbutamide | 2002 |
A novel simple method for the investigation of drug binding to the K(ATP) channel sulfonylurea receptor.
Topics: Animals; ATP-Binding Cassette Transporters; Carbamates; Gliclazide; Glyburide; Hypoglycemic Agents; Kinetics; Piperidines; Potassium Channels; Potassium Channels, Inwardly Rectifying; Protein Binding; Rats; Receptors, Drug; Spodoptera; Sulfonylurea Receptors; Tolbutamide | 2002 |
Glucose-dependent and glucose-sensitizing insulinotropic effect of nateglinide: comparison to sulfonylureas and repaglinide.
Topics: Animals; Carbamates; Cyclohexanes; Glucose; Hypoglycemic Agents; Insulin; Insulin Secretion; Islets of Langerhans; Kinetics; Male; Nateglinide; Phenylalanine; Piperidines; Rats; Rats, Sprague-Dawley; Sulfonylurea Compounds | 2001 |
Effectiveness of nateglinide on in vitro insulin secretion from rat pancreatic islets desensitized to sulfonylureas.
Topics: Animals; Carbamates; Cyclohexanes; Hypoglycemic Agents; Insulin; Insulin Secretion; Islets of Langerhans; Male; Nateglinide; Phenylalanine; Piperidines; Rats; Rats, Sprague-Dawley; Sulfonylurea Compounds | 2001 |
[Glinides and glitazones in diabetes treatment. Are they really effective?].
Topics: Carbamates; Cyclohexanes; Diabetes Mellitus, Type 2; Drug Therapy, Combination; Humans; Hypoglycemic Agents; Insulin; Nateglinide; Phenylalanine; Pioglitazone; Piperidines; Rosiglitazone; Thiazoles; Thiazolidinediones; Treatment Outcome | 2002 |
Effects of S 21403 on hormone secretion from isolated rat pancreas at different glucose concentrations.
Topics: Animals; Carbamates; Dose-Response Relationship, Drug; Glucose; Glyburide; Hypoglycemic Agents; In Vitro Techniques; Indoles; Insulin; Insulin Secretion; Isoindoles; Male; Pancreas; Piperidines; Rats; Rats, Sprague-Dawley; Time Factors | 2002 |
Hypoglycemia probably due to accidental intake of repaglinide.
Topics: Adolescent; Carbamates; Female; Humans; Hypoglycemia; Hypoglycemic Agents; Medication Errors; Piperidines | 2002 |
Pharmacologic restoration of the early insulin response in pre-diabetic monkeys controls mealtime glucose excursions without peripheral hyperinsulinaemia.
Topics: Animals; Blood Glucose; Carbamates; Cyclohexanes; Fatty Acids, Nonesterified; Food; Glucagon; Hypoglycemic Agents; Insulin; Insulin Secretion; Kinetics; Macaca fascicularis; Male; Nateglinide; Phenylalanine; Piperidines | 2003 |
[Differences between oral antidiabetics].
Topics: Administration, Oral; Carbamates; Cyclohexanes; Diabetes Mellitus; Glipizide; Humans; Hypoglycemic Agents; Insulin; Insulin Secretion; Nateglinide; Phenylalanine; Piperidines; Sulfonylurea Compounds | 2003 |
Repaglinide at a cellular level.
Topics: Animals; Carbamates; Cyclohexanes; Electrophysiology; Exocytosis; Hypoglycemic Agents; Islets of Langerhans; Membrane Potentials; Nateglinide; Phenylalanine; Piperidines; Postprandial Period; Potassium Channels; Rats | 2002 |
Neuronal calcium sensor proteins are direct targets of the insulinotropic agent repaglinide.
Topics: Animals; Bryopsida; Calcium-Binding Proteins; Calcium-Calmodulin-Dependent Protein Kinases; Calmodulin; Carbamates; Cattle; Chromatography, Affinity; Eye Proteins; G-Protein-Coupled Receptor Kinase 1; Hippocalcin; Hypoglycemic Agents; Insulin; Lipoproteins; Nerve Tissue Proteins; Neurocalcin; Neurons; Phosphorylation; Piperidines; Protein Kinases; Receptors, Calcium-Sensing; Recoverin; Retina | 2003 |
Economic model of first-line drug strategies to achieve recommended glycaemic control in newly diagnosed type 2 diabetes mellitus.
Topics: Carbamates; Cohort Studies; Decision Trees; Diabetes Mellitus, Type 2; Direct Service Costs; Drug Costs; Drug Therapy, Combination; Glipizide; Glyburide; Glycated Hemoglobin; Humans; Hypoglycemic Agents; Managed Care Programs; Markov Chains; Metformin; Models, Economic; Piperidines; Rosiglitazone; Thiazoles; Thiazolidinediones; United States | 2003 |
A comparison of costs for four oral antidiabetic regimens within a managed care population.
Topics: Administration, Oral; Adolescent; Adult; Aged; California; Carbamates; Cohort Studies; Data Interpretation, Statistical; Diabetes Mellitus, Type 2; Drug Therapy, Combination; Female; Glyburide; Health Care Costs; Humans; Hypoglycemic Agents; Insulin; Insurance Claim Review; Male; Managed Care Programs; Metformin; Middle Aged; Piperidines; Retrospective Studies | 2003 |
CYP2C8 and CYP3A4 are the principal enzymes involved in the human in vitro biotransformation of the insulin secretagogue repaglinide.
Topics: Antibodies, Monoclonal; Aryl Hydrocarbon Hydroxylases; Biotransformation; Carbamates; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP2C8; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Drug Interactions; Humans; Hypoglycemic Agents; Microsomes, Liver; Piperidines | 2003 |
Impurity profile study of repaglinide.
Topics: Carbamates; Chromatography, High Pressure Liquid; Drug Contamination; Hypoglycemic Agents; Magnetic Resonance Spectroscopy; Mass Spectrometry; Piperidines; Spectroscopy, Fourier Transform Infrared | 2003 |
[Type 2 diabetes mellitus pathogenesis: new therapeutic managements?].
Topics: Carbamates; Diabetes Mellitus, Type 2; Humans; Hypoglycemic Agents; Insulin; Insulin Resistance; Insulin Secretion; Piperidines; Treatment Outcome | 2003 |
Glimepiride and serum adiponectin level in type 2 diabetic subjects: response to Nagasaka et al.
Topics: Adiponectin; Blood Glucose; Carbamates; Cyclohexanes; Diabetes Mellitus, Type 2; Humans; Hypoglycemic Agents; Intercellular Signaling Peptides and Proteins; Nateglinide; Phenylalanine; Piperidines; Proteins; Sulfonylurea Compounds | 2003 |
Comparison of repaglinide and nateglinide in combination with metformin: response to Raskin et al.
Topics: Carbamates; Cyclohexanes; Diabetes Mellitus, Type 2; Drug Therapy, Combination; Glycated Hemoglobin; Humans; Hypoglycemic Agents; Metformin; Nateglinide; Phenylalanine; Piperidines | 2003 |
Determination of repaglinide in pharmaceutical formulations by HPLC with UV detection.
Topics: Calibration; Carbamates; Chromatography, High Pressure Liquid; Hypoglycemic Agents; Pharmaceutical Preparations; Piperidines; Reproducibility of Results | 2003 |
Optimal glycemic control in type 2 diabetes mellitus: fasting and postprandial glucose in context.
Topics: Antihypertensive Agents; Blood Glucose; Blood Glucose Self-Monitoring; Carbamates; Diabetes Mellitus, Type 2; Diabetic Angiopathies; Disease Progression; Drug Therapy, Combination; Glyburide; Glycated Hemoglobin; Glycoside Hydrolase Inhibitors; Humans; Hyperglycemia; Hypoglycemic Agents; Metformin; Piperidines; Postprandial Period | 2004 |
Evidence for hypothalamic K+(ATP) channels in the modulation of glucose homeostasis.
Topics: Animals; Blood Glucose; Carbamates; Chromatography, High Pressure Liquid; Epinephrine; Glucagon; Glyburide; Homeostasis; Hypoglycemic Agents; Hypothalamus; Male; Norepinephrine; Piperidines; Potassium Channel Blockers; Potassium Channels; Rats; Rats, Sprague-Dawley | 2004 |
Studies on the glycemic and lipidemic effect of monopril and losartan in normal and diabetic rats.
Topics: Alloxan; Animals; Blood Glucose; Blood Proteins; Carbamates; Cholesterol, LDL; Diabetes Mellitus, Experimental; Disease Models, Animal; Drug Therapy, Combination; Egypt; Fosinopril; Gliclazide; Hyperlipidemias; Hypolipidemic Agents; Lipids; Losartan; Male; Piperidines; Rats; Rats, Sprague-Dawley; Triglycerides | 2004 |
Synthesis and evaluation of (S)-2-(2-[18F]fluoroethoxy)-4-([3-methyl-1-(2-piperidin-1-yl-phenyl)-butyl-carbamoyl]-methyl)-benzoic acid ([18F]repaglinide): a promising radioligand for quantification of pancreatic beta-cell mass with positron emission tomog
Topics: Animals; ATP-Binding Cassette Transporters; Carbamates; Feasibility Studies; Fluorine Radioisotopes; Islets of Langerhans; Isotope Labeling; Metabolic Clearance Rate; Multidrug Resistance-Associated Proteins; Organ Specificity; Piperidines; Positron-Emission Tomography; Potassium Channels, Inwardly Rectifying; Radiopharmaceuticals; Rats; Rats, Inbred Lew; Rats, Sprague-Dawley; Receptors, Drug; Sulfonylurea Receptors; Tissue Distribution | 2004 |
Taurine block of cloned ATP-sensitive K+ channels with different sulfonylurea receptor subunits expressed in Xenopus laevis oocytes.
Topics: Animals; ATP-Binding Cassette Transporters; Carbamates; Drug Interactions; Female; Gene Expression; Gliclazide; Glyburide; Hypoglycemic Agents; Membrane Proteins; Mice; Oocytes; Piperidines; Potassium Channels; Potassium Channels, Inwardly Rectifying; Protein Subunits; Rats; Receptors, Drug; Sulfonylurea Receptors; Taurine; Tolbutamide; Xenopus laevis | 2004 |
Comparing the long-term cost-effectiveness of repaglinide plus metformin versus nateglinide plus metformin in type 2 diabetes patients with inadequate glycaemic control: an application of the CORE Diabetes Model in type 2 diabetes.
Topics: Carbamates; Cohort Studies; Computer Simulation; Cost of Illness; Cost-Benefit Analysis; Cyclohexanes; Decision Support Systems, Clinical; Diabetes Complications; Diabetes Mellitus, Type 2; Drug Therapy, Combination; Female; Glycated Hemoglobin; Health Care Costs; Humans; Male; Metformin; Middle Aged; Models, Econometric; Nateglinide; Outcome Assessment, Health Care; Phenylalanine; Piperidines; Quality-Adjusted Life Years | 2004 |
Synthesis and in vitro evaluation of (S)-2-([11C]methoxy)-4-[3-methyl-1-(2-piperidine-1-yl-phenyl)-butyl-carbamoyl]-benzoic acid ([11C]methoxy-repaglinide): a potential beta-cell imaging agent.
Topics: Animals; ATP-Binding Cassette Transporters; Benzoates; Binding, Competitive; Carbamates; Carbon Radioisotopes; COS Cells; Humans; Hydroxybenzoate Ethers; In Vitro Techniques; Insulin; Insulin Secretion; Islets of Langerhans; Piperidines; Positron-Emission Tomography; Potassium Channels; Potassium Channels, Inwardly Rectifying; Radiopharmaceuticals; Rats; Receptors, Drug; Stereoisomerism; Sulfonylurea Receptors | 2004 |
Sulfonylurea induced beta-cell apoptosis in cultured human islets.
Topics: Adult; Aged; Apoptosis; Calcium; Carbamates; Cells, Cultured; Cyclohexanes; Dose-Response Relationship, Drug; Glyburide; Humans; Hypoglycemic Agents; Insulin; Islets of Langerhans; Middle Aged; Nateglinide; Phenylalanine; Piperidines | 2005 |
Continuous glucose monitoring: physiologic and pathophysiologic significance.
Topics: Adolescent; Adult; Biomarkers; Blood Glucose; Blood Glucose Self-Monitoring; Carbamates; Circadian Rhythm; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Female; Humans; Hypoglycemic Agents; Insulin; Male; Middle Aged; Monitoring, Physiologic; Piperidines; Postprandial Period; Statistics as Topic; Treatment Outcome | 2004 |
Acute hepatotoxicity caused by repaglinide.
Topics: Aged; Carbamates; Chemical and Drug Induced Liver Injury; Diabetes Mellitus, Type 2; Humans; Hyperglycemia; Hypoglycemic Agents; Male; Piperidines | 2004 |
Treating type 2 diabetes. When diet and exercise aren't enough, a broad range of medications can help control our blood sugar.
Topics: Carbamates; Cyclohexanes; Diabetes Mellitus, Type 2; Drug Administration Schedule; Eating; Humans; Hypoglycemic Agents; Nateglinide; Phenylalanine; Piperidines | 2004 |
Kir6.2-dependent high-affinity repaglinide binding to beta-cell K(ATP) channels.
Topics: Animals; ATP-Binding Cassette Transporters; Binding, Competitive; Carbamates; Cell Line; Cell Membrane; Drug Interactions; Humans; Hypoglycemic Agents; Islets of Langerhans; Mice; Patch-Clamp Techniques; Piperidines; Potassium Channels; Potassium Channels, Inwardly Rectifying; Receptors, Drug; Sulfonylurea Receptors | 2005 |
Accuracy of continuous nocturnal glucose screening after 48 and 72 hours in type 2 diabetes patients on combined oral and insulin therapy.
Topics: Administration, Oral; Aged; Body Mass Index; Carbamates; Diabetes Mellitus, Type 2; Drug Therapy, Combination; Glycated Hemoglobin; Humans; Hypoglycemic Agents; Insulin; Middle Aged; Monitoring, Ambulatory; Monitoring, Physiologic; Piperidines; Regression Analysis; Reproducibility of Results; Time Factors | 2004 |
Cholestatic hepatitis associated with repaglinide.
Topics: Aged; Carbamates; Chemical and Drug Induced Liver Injury; Cholestasis; Diabetes Mellitus, Type 2; Humans; Hypoglycemic Agents; Male; Piperidines | 2005 |
In vitro and pharmacophore-based discovery of novel hPEPT1 inhibitors.
Topics: Animals; Aspartame; Carbamates; Cell Line; CHO Cells; Computer Simulation; Cricetinae; Cricetulus; Databases, Factual; Dipeptides; Drug Design; Fatty Acids, Monounsaturated; Fluvastatin; Indoles; Ligands; Models, Molecular; Molecular Conformation; Peptide Transporter 1; Piperidines; Protein Binding; Structure-Activity Relationship; Symporters | 2005 |
Effects of repaglinide on oxidative stress in tissues of diabetic rabbits.
Topics: Administration, Oral; Animals; Blood Glucose; Body Weight; Carbamates; Diabetes Mellitus, Experimental; Glutathione Peroxidase; Glutathione Reductase; Hypoglycemic Agents; Kidney; Liver; Male; Oxidative Stress; Piperidines; Rabbits; Time Factors | 2005 |
Mild, reversible pancytopenia induced by rosiglitazone.
Topics: Carbamates; Diabetes Mellitus, Type 2; Dose-Response Relationship, Drug; Humans; Hypoglycemic Agents; Male; Middle Aged; Piperidines; Rosiglitazone; Thiazolidinediones | 2005 |
Oxidative stress in kidney and liver of alloxan-induced diabetic rabbits: effect of repaglinide.
Topics: Animals; Blood Glucose; Body Weight; Carbamates; Catalase; Diabetes Mellitus, Experimental; Hypoglycemic Agents; Oxidative Stress; Piperidines; Rabbits; Superoxide Dismutase | 2005 |
Polymorphic organic anion transporting polypeptide 1B1 is a major determinant of repaglinide pharmacokinetics.
Topics: Adult; Aryl Hydrocarbon Hydroxylases; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP-Binding Cassette Transporters; Carbamates; Cytochrome P-450 CYP2C8; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Female; Genes, MDR; Genotype; Humans; Hypoglycemic Agents; Liver-Specific Organic Anion Transporter 1; Male; Piperidines; Polymorphism, Single Nucleotide | 2005 |
Antioxidative and anti-inflammatory effects of repaglinide in plasma of diabetic animals.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Ascorbic Acid; Blood Glucose; Carbamates; Diabetes Mellitus, Experimental; Hypoglycemic Agents; Insulin; Piperidines; Rabbits | 2005 |
Calcium silicate based microspheres of repaglinide for gastroretentive floating drug delivery: preparation and in vitro characterization.
Topics: Algorithms; Biological Availability; Calcium Compounds; Calorimetry, Differential Scanning; Carbamates; Drug Carriers; Drug Delivery Systems; Half-Life; Hypoglycemic Agents; Microscopy, Electron, Scanning; Microspheres; Particle Size; Piperidines; Silicates; Solubility; Temperature | 2005 |
Modification of cardiac oxidative stress in alloxan-induced diabetic rabbits with repaglinide treatment.
Topics: Alloxan; Animals; Antioxidants; Blood Glucose; Carbamates; Diabetes Mellitus, Experimental; Insulin; Male; Myocardium; Oxidative Stress; Piperidines; Rabbits | 2005 |
Metabolism of repaglinide by CYP2C8 and CYP3A4 in vitro: effect of fibrates and rifampicin.
Topics: Aryl Hydrocarbon Hydroxylases; Bezafibrate; Carbamates; Cytochrome P-450 CYP2C8; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Drug Interactions; Fenofibrate; Gemfibrozil; Humans; Hypoglycemic Agents; In Vitro Techniques; Itraconazole; Microsomes, Liver; Midazolam; Paclitaxel; Piperidines; Quercetin; Rifampin | 2005 |
Oral agents in managing diabetes mellitus in children and adolescents.
Topics: Administration, Oral; Adolescent; Carbamates; Child; Clinical Trials as Topic; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Humans; Hypoglycemic Agents; Metformin; Piperidines; Sulfonylurea Compounds; Thiazolidinediones; Treatment Outcome | 2005 |
[Synthesis and insulinotropic activity of 2-benzylidenesuccinic acid derivatives].
Topics: Animals; Benzylidene Compounds; Blood Glucose; Carbamates; Cyclohexanes; Hypoglycemic Agents; Indoles; Isoindoles; Mice; Molecular Structure; Nateglinide; Phenylalanine; Piperidines; Structure-Activity Relationship; Succinates | 2005 |
Simultaneous estimation of six anti-diabetic drugs--glibenclamide, gliclazide, glipizide, pioglitazone, repaglinide and rosiglitazone: development of a novel HPLC method for use in the analysis of pharmaceutical formulations and its application to human p
Topics: Carbamates; Chromatography, High Pressure Liquid; Gliclazide; Glipizide; Glyburide; Humans; Hypoglycemic Agents; Molecular Structure; Pioglitazone; Piperidines; Reproducibility of Results; Rosiglitazone; Thiazolidinediones | 2006 |
Ionization, lipophilicity and solubility properties of repaglinide.
Topics: Carbamates; Hydrogen-Ion Concentration; Hypoglycemic Agents; Isoelectric Point; Lipids; Piperidines; Solubility; Spectrophotometry, Ultraviolet | 2006 |
Safety profile of repaglinide as used in general practice in England: results of a prescription-event monitoring study.
Topics: Aged; Carbamates; Cause of Death; Cohort Studies; Diabetes Mellitus, Type 2; Drug Prescriptions; England; Family Practice; Female; Humans; Hypoglycemic Agents; Infant; Middle Aged; Piperidines; Pregnancy; Safety; State Medicine; Survival Analysis; Vision Disorders | 2006 |
A novel calcium silicate based microspheres of repaglinide: in vivo investigations.
Topics: Animals; Calcium Compounds; Carbamates; Male; Microspheres; Piperidines; Rabbits; Rats; Rats, Sprague-Dawley; Silicates; Tissue Distribution | 2006 |
A comparison of glycemic effects of glimepiride, repaglinide, and insulin glargine in type 2 diabetes mellitus during Ramadan fasting.
Topics: Adult; Body Mass Index; Carbamates; Diabetes Mellitus, Type 2; Fasting; Female; Fructosamine; Glycated Hemoglobin; Humans; Hypoglycemic Agents; Insulin; Insulin Glargine; Insulin, Long-Acting; Islam; Male; Middle Aged; Patient Selection; Piperidines; Sulfonylurea Compounds; Turkey | 2007 |
Selectivity of repaglinide and glibenclamide for the pancreatic over the cardiovascular K(ATP) channels.
Topics: Adenosine Triphosphate; ATP-Binding Cassette Transporters; Binding, Competitive; Carbamates; Cardiovascular System; Cell Line; Dose-Response Relationship, Drug; Glyburide; Humans; Hypoglycemic Agents; Membrane Potentials; Molecular Structure; Pancreas; Patch-Clamp Techniques; Piperidines; Potassium Channels; Potassium Channels, Inwardly Rectifying; Receptors, Drug; Sulfonylurea Receptors | 2006 |
Cyclosporine A increases plasma concentrations and effects of repaglinide.
Topics: Carbamates; Cyclosporine; Cytochrome P-450 Enzyme System; Drug Interactions; Humans; Hypoglycemic Agents; Immunosuppressive Agents; Organic Anion Transporters; Piperidines | 2006 |
Pharmacological interaction between cyclosporine a and repaglinide. Is it clinically relevant?
Topics: Carbamates; Cyclosporine; Cytochrome P-450 Enzyme System; Drug Interactions; Humans; Hypoglycemic Agents; Immunosuppressive Agents; Organic Anion Transporters; Piperidines | 2006 |
Use of repaglinide during the first weeks of pregnancy in two type 2 diabetic women.
Topics: Adult; Carbamates; Diabetes Mellitus, Type 2; Female; Humans; Insulin; Piperidines; Pregnancy; Pregnancy in Diabetics; Pregnancy Trimester, First | 2006 |
Glibenclamide attenuates the antiarrhythmic effect of endotoxin with a mechanism not involving K(ATP) channels.
Topics: Action Potentials; Adenosine Triphosphate; Animals; Arrhythmias, Cardiac; Blood Pressure; Carbamates; Cyclohexanes; Disease Models, Animal; Drug Interactions; Endotoxemia; Glyburide; Heart Atria; Heart Conduction System; Lipopolysaccharides; Male; Myocardial Ischemia; Nateglinide; Phenylalanine; Piperidines; Potassium Channel Blockers; Potassium Channels; Rats; Rats, Sprague-Dawley; Tachycardia, Ventricular; Tetraethylammonium; Time Factors; Ventricular Fibrillation; Ventricular Premature Complexes | 2007 |
Use of repaglinide on a pregnant woman during embryogenesis.
Topics: Adult; Carbamates; Diabetes Mellitus, Type 2; Embryonic Development; Female; Humans; Hypoglycemic Agents; Infant, Newborn; Maternal-Fetal Exchange; Piperidines; Pregnancy; Pregnancy in Diabetics | 2007 |
Method development and validation of repaglinide in human plasma by HPLC and its application in pharmacokinetic studies.
Topics: Carbamates; Chromatography, High Pressure Liquid; Drug Stability; Freezing; Humans; Hypoglycemic Agents; Molecular Structure; Piperidines; Reference Standards; Reproducibility of Results; Sensitivity and Specificity | 2007 |
Development of a RP-HPLC method for screening potentially counterfeit anti-diabetic drugs.
Topics: Carbamates; Chromatography, High Pressure Liquid; Gliclazide; Glipizide; Glyburide; Hypoglycemic Agents; Molecular Structure; Piperidines; Reproducibility of Results; Sulfonylurea Compounds | 2007 |
Testing the bipartite model of the sulfonylurea receptor binding site: binding of A-, B-, and A + B-site ligands.
Topics: Amino Acid Substitution; Animals; ATP-Binding Cassette Transporters; Binding Sites; Binding, Competitive; Carbamates; Cell Line; Cyclohexanes; Dose-Response Relationship, Drug; Glyburide; Hypoglycemic Agents; KATP Channels; Ligands; Mice; Molecular Structure; Nateglinide; Phenylalanine; Piperidines; Potassium Channels; Potassium Channels, Inwardly Rectifying; Protein Binding; Radioligand Assay; Rats; Receptors, Drug; Sulfonylurea Compounds; Sulfonylurea Receptors; Transfection | 2007 |
Porous carrier based floating granular delivery system of repaglinide.
Topics: Acrylic Resins; Administration, Oral; Animals; Biological Availability; Calcium Compounds; Carbamates; Cellulose; Chemistry, Pharmaceutical; Delayed-Action Preparations; Drug Carriers; Gastrointestinal Transit; Hypoglycemic Agents; Hypromellose Derivatives; Male; Methylcellulose; Particle Size; Piperidines; Polymers; Porosity; Rabbits; Radionuclide Imaging; Silicates | 2007 |
Rapidly dissolving repaglinide powders produced by the ultra-rapid freezing process.
Topics: Carbamates; Chemistry, Pharmaceutical; Freezing; Hydrogen-Ion Concentration; Piperidines; Powders; Solubility; Technology, Pharmaceutical; X-Ray Diffraction | 2007 |
Characterization of novel CYP2C8 haplotypes and their contribution to paclitaxel and repaglinide metabolism.
Topics: Aryl Hydrocarbon Hydroxylases; Carbamates; Cytochrome P-450 CYP2C8; Genetic Variation; Haplotypes; Humans; Paclitaxel; Piperidines; White People | 2008 |
Electrochemical determination of the antidiabetic drug repaglinide.
Topics: Carbamates; Carbon; Electrochemistry; Electrodes; Humans; Hydrogen-Ion Concentration; Hypoglycemic Agents; Oxidation-Reduction; Piperidines; Tablets | 2008 |
Spermicidal activity of sulfonylureas and meglitinide analogues: role of intrasperm Ca2+ elevation.
Topics: Adult; Benzamides; Calcium; Carbamates; Cross-Over Studies; Dose-Response Relationship, Drug; Gliclazide; Glyburide; Homeostasis; Humans; Hypoglycemic Agents; KATP Channels; Male; Piperidines; Sperm Motility; Spermatocidal Agents; Spermatozoa; Sulfonylurea Compounds; Time Factors | 2008 |
Postprandial hyperglycemia: are all sulfonylureas created equal?
Topics: Carbamates; Cyclohexanes; Glipizide; Humans; Hyperglycemia; Hyperlipidemias; Hypoglycemic Agents; Nateglinide; Phenylalanine; Piperidines; Postprandial Period; Sulfonylurea Compounds | 2008 |
Interaction of oral antidiabetic drugs with hepatic uptake transporters: focus on organic anion transporting polypeptides and organic cation transporter 1.
Topics: Administration, Oral; Animals; Biological Transport; Carbamates; Cell Line; Dogs; Hepatocytes; Humans; Hypoglycemic Agents; Kidney; Kinetics; Liver; Liver-Specific Organic Anion Transporter 1; Metformin; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Piperidines; Pravastatin; Recombinant Proteins; Rosiglitazone; Solute Carrier Organic Anion Transporter Family Member 1B3; Thiazolidinediones | 2008 |
Application of software design principles and debugging methods to an analgesia prescription reduces risk of severe injury from medical use of opioids.
Topics: Adult; Aged; Analgesia, Patient-Controlled; Analgesics, Opioid; Blood Glucose; Carbamates; Clinical Trials as Topic; Drug Interactions; Female; Gemfibrozil; Hospital Mortality; Humans; Hypoglycemic Agents; Hypolipidemic Agents; Male; Medication Errors; Middle Aged; Multicenter Studies as Topic; Pain; Patient-Centered Care; Piperidines; Software | 2008 |
Achieving glycosylated hemoglobin targets using the combination of repaglinide and metformin in type 2 diabetes: a reanalysis of earlier data in terms of current targets.
Topics: Biomarkers; Carbamates; Diabetes Mellitus, Type 2; Drug Therapy, Combination; Glycated Hemoglobin; Humans; Hypoglycemic Agents; Metformin; Piperidines; Randomized Controlled Trials as Topic; Treatment Outcome | 2008 |
Severe hypoglycemia from clarithromycin-repaglinide drug interaction.
Topics: Aged, 80 and over; Anti-Bacterial Agents; Blood Glucose; Carbamates; Clarithromycin; Diabetes Mellitus, Type 2; Drug Interactions; Helicobacter Infections; Humans; Hypoglycemia; Hypoglycemic Agents; Male; Piperidines | 2008 |
Association of KCNJ11 and ABCC8 genetic polymorphisms with response to repaglinide in Chinese diabetic patients.
Topics: ATP-Binding Cassette Transporters; Carbamates; Diabetes Mellitus, Type 2; DNA; Female; Gene Frequency; Genotype; Glycated Hemoglobin; Humans; Hypoglycemic Agents; Male; Middle Aged; Piperidines; Polymorphism, Genetic; Potassium Channels, Inwardly Rectifying; Receptors, Drug; Sulfonylurea Receptors | 2008 |
The effect of SLCO1B1 polymorphism on repaglinide pharmacokinetics persists over a wide dose range.
Topics: Area Under Curve; Blood Glucose; Carbamates; Diabetes Mellitus, Type 2; Female; Genotype; Humans; Hypoglycemic Agents; Liver-Specific Organic Anion Transporter 1; Male; Metabolic Clearance Rate; Organic Anion Transporters; Piperidines; Polymorphism, Single Nucleotide; Young Adult | 2008 |
Repaglinide plus single-dose insulin glargine: a safe regimen for low-risk type 2 diabetic patients who insist on fasting in Ramadan.
Topics: Adult; Aged; Blood Glucose; Blood Glucose Self-Monitoring; Blood Pressure; Carbamates; Diabetes Mellitus, Type 2; Drug Administration Schedule; Fasting; Female; Fructosamine; Humans; Hypoglycemia; Hypoglycemic Agents; Insulin; Insulin Glargine; Insulin, Long-Acting; Islam; Male; Middle Aged; Patient Selection; Piperidines; Risk Assessment; Safety; Turkey | 2009 |
Reversible binding of antidiabetic drugs, repaglinide and gliclazide, with human serum albumin.
Topics: Anilino Naphthalenesulfonates; Binding Sites; Carbamates; Fluorescent Dyes; Gliclazide; Humans; Hydrophobic and Hydrophilic Interactions; Hypoglycemic Agents; Models, Biological; Piperidines; Protein Binding; Serum Albumin; Spectrometry, Fluorescence; Thermodynamics; Tryptophan | 2008 |
Hypoglycaemia with oral antidiabetic drugs: results from prescription-event monitoring cohorts of rosiglitazone, pioglitazone, nateglinide and repaglinide.
Topics: Administration, Oral; Adult; Adverse Drug Reaction Reporting Systems; Carbamates; Cohort Studies; Cyclohexanes; Diabetes Mellitus, Type 2; Drug Monitoring; Drug Prescriptions; Female; Humans; Hypoglycemia; Hypoglycemic Agents; Incidence; Male; Middle Aged; Nateglinide; Phenylalanine; Pioglitazone; Piperidines; Rosiglitazone; Sex Factors; Thiazolidinediones | 2009 |
Metformin/Repaglinide (PrandiMet) for type 2 diabetes.
Topics: Administration, Oral; Carbamates; Diabetes Mellitus, Type 2; Drug Combinations; Drug Interactions; Glycated Hemoglobin; Humans; Hypoglycemic Agents; Metformin; Piperidines; Tablets; Treatment Outcome | 2009 |
Change in glucometer settings as a cause of sudden deterioration of glycemic control in type 2 diabetes.
Topics: Blood Glucose; Blood Glucose Self-Monitoring; Carbamates; Computers; Diabetes Mellitus, Type 2; Equipment Failure; Fasting; Female; Glycated Hemoglobin; Humans; Hypoglycemic Agents; Insulin; Metformin; Middle Aged; Piperidines; Self Care; Software | 2009 |
Metabonomic variations in the drug-treated type 2 diabetes mellitus patients and healthy volunteers.
Topics: Carbamates; Diabetes Mellitus, Type 2; Gas Chromatography-Mass Spectrometry; Humans; Hypoglycemic Agents; Lactic Acid; Lysine; Metabolomics; Metformin; Piperidines; Rosiglitazone; Thiazolidinediones; Uric Acid; Valine | 2009 |
Successful treatment of repaglinide-induced hypoglycemia with octreotide.
Topics: Aged, 80 and over; Carbamates; Gastrointestinal Agents; Humans; Hypoglycemia; Hypoglycemic Agents; Male; Octreotide; Piperidines | 2009 |
Modulation of nitrosative/oxidative stress in the lung of hyperglycemic rabbits by two antidiabetics, pioglitazone and repaglinide.
Topics: Administration, Oral; Animals; Blood Glucose; Carbamates; Catalase; Diabetes Mellitus, Experimental; Glutathione; Glutathione Peroxidase; Hyperglycemia; Hypoglycemic Agents; Lipid Peroxidation; Lung; Male; Oxidative Stress; Pioglitazone; Piperidines; Rabbits; Reactive Nitrogen Species; Superoxide Dismutase; Thiazolidinediones; Tyrosine | 2009 |
Synthesis of pharmacokinetic pathways through knowledge acquisition and automated reasoning.
Topics: Artificial Intelligence; Carbamates; Computational Biology; Humans; Knowledge Bases; MEDLINE; Metabolic Networks and Pathways; Models, Biological; Pharmacokinetics; Piperidines; Pravastatin; Synthetic Biology | 2010 |
Glinide, but not sulfonylurea, can evoke insulin exocytosis by repetitive stimulation: imaging analysis of insulin exocytosis by secretagogue-induced repetitive stimulations.
Topics: Animals; Calcium; Carbamates; Cell Fusion; Cells, Cultured; Cyclohexanes; Exocytosis; Glucose; Hypoglycemic Agents; Insulin; Insulin Secretion; Insulin-Secreting Cells; Mice; Mice, Inbred C57BL; Microscopy, Fluorescence; Nateglinide; Phenylalanine; Piperidines; Sulfonylurea Compounds | 2009 |
Diabetes under control: Understanding oral antidiabetic agents.
Topics: Administration, Oral; Biguanides; Carbamates; Cyclohexanes; Diabetes Mellitus, Type 2; Dipeptidyl-Peptidase IV Inhibitors; Drug Combinations; Drug Therapy, Combination; Glycoside Hydrolase Inhibitors; Humans; Hypoglycemic Agents; Nateglinide; Phenylalanine; Piperidines; Sulfonylurea Compounds | 2010 |
Population pharmacokinetic modelling of repaglinide in healthy volunteers by using Non-Parametric Adaptive Grid Algorithm.
Topics: Adolescent; Adult; Algorithms; Body Mass Index; Carbamates; Female; Half-Life; Humans; Hypoglycemic Agents; Male; Metabolic Clearance Rate; Middle Aged; Models, Biological; Piperidines; Young Adult | 2010 |
Symptomatic hypoglycemia associated with trimethoprim/sulfamethoxazole and repaglinide in a diabetic patient.
Topics: Aged; Anti-Infective Agents, Urinary; Blood Glucose; Carbamates; Diabetes Complications; Diabetes Mellitus; Diabetic Neuropathies; Drug Interactions; Energy Intake; Humans; Hypoglycemia; Hypoglycemic Agents; Male; Piperidines; Trimethoprim, Sulfamethoxazole Drug Combination; Urinary Tract Infections | 2010 |
Bioavailability and biological activity of liquisolid compact formula of repaglinide and its effect on glucose tolerance in rabbits.
Topics: Administration, Oral; Animals; Area Under Curve; Biological Availability; Blood Glucose; Carbamates; Chromatography, High Pressure Liquid; Dosage Forms; Drug Compounding; Glucose Tolerance Test; Humans; Hypoglycemic Agents; Insulin; Male; Piperidines; Rabbits; Random Allocation; Reproducibility of Results; Sensitivity and Specificity | 2010 |
A variation in NOS1AP gene is associated with repaglinide efficacy on insulin resistance in type 2 diabetes of Chinese.
Topics: Adaptor Proteins, Signal Transducing; Carbamates; China; Diabetes Mellitus, Type 2; Female; Humans; Hypoglycemic Agents; Insulin Resistance; Male; Middle Aged; Piperidines; Polymorphism, Single Nucleotide | 2010 |
CYP3A4 genetic polymorphism influences repaglinide's pharmacokinetics.
Topics: Adolescent; Adult; Aryl Hydrocarbon Hydroxylases; Asian People; Carbamates; Cytochrome P-450 CYP2C8; Cytochrome P-450 CYP3A; Genotype; Humans; Hypoglycemic Agents; Middle Aged; Piperidines; Polymorphism, Genetic; Young Adult | 2010 |
IGF2BP2 variations influence repaglinide response and risk of type 2 diabetes in Chinese population.
Topics: Adult; Aged; Asian People; Carbamates; Case-Control Studies; Diabetes Mellitus, Type 2; Female; Gene Frequency; Humans; Hypoglycemic Agents; Insulin; Male; Middle Aged; Piperidines; Polymorphism, Genetic; Risk Factors; RNA-Binding Proteins | 2010 |
In vitro characterization and invivo toxicity study of repaglinide loaded poly (methyl methacrylate) nanoparticles.
Topics: Animals; Calorimetry, Differential Scanning; Carbamates; Chemistry, Pharmaceutical; Delayed-Action Preparations; Drug Carriers; Drug Compounding; Female; Hypoglycemic Agents; Kinetics; Male; Microscopy, Electron, Scanning; Models, Chemical; Nanoparticles; Nanotechnology; Particle Size; Piperidines; Polymethyl Methacrylate; Rats; Rats, Wistar; Solubility; Spectroscopy, Fourier Transform Infrared; Technology, Pharmaceutical; Thermogravimetry; X-Ray Diffraction | 2010 |
Small molecule inhibitors of the human papillomavirus E1-E2 interaction.
Topics: Antiviral Agents; Binding Sites; Carbamates; DNA-Binding Proteins; Drug Evaluation, Preclinical; Humans; Indans; Molecular Dynamics Simulation; Papillomaviridae; Piperidines; Protein Binding; Protein Conformation; Viral Proteins | 2011 |
Association analysis of SLC30A8 rs13266634 and rs16889462 polymorphisms with type 2 diabetes mellitus and repaglinide response in Chinese patients.
Topics: Adult; Aged; Base Sequence; Carbamates; Case-Control Studies; Cation Transport Proteins; China; Diabetes Mellitus, Type 2; DNA Primers; Female; Gene Frequency; Genome-Wide Association Study; Humans; Hypoglycemic Agents; Male; Middle Aged; Piperidines; Polymerase Chain Reaction; Polymorphism, Genetic; Zinc Transporter 8 | 2010 |
[Electrocardiographic score: application in exercise test for the assessment of ischemic preconditioning].
Topics: Carbamates; Diabetes Mellitus; Double-Blind Method; Electrocardiography; Ergometry; Female; Humans; Hypoglycemic Agents; Ischemic Preconditioning; Male; Middle Aged; Myocardial Ischemia; Observer Variation; Piperidines; Predictive Value of Tests | 2010 |
Repaglinide-loaded long-circulating biodegradable nanoparticles: rational approach for the management of type 2 diabetes mellitus.
Topics: Administration, Oral; Animals; Blood Glucose; Carbamates; Chemistry, Pharmaceutical; Delayed-Action Preparations; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Disease Models, Animal; Drug Compounding; Hypoglycemic Agents; Lactic Acid; Male; Nanoparticles; Particle Size; Piperidines; Polyethylene Glycols; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Rats; Rats, Sprague-Dawley; Solubility | 2009 |
Electrochemical characterization of repaglinide and its determination in human plasma using liquid chromatography with dual-channel coulometric detection.
Topics: Carbamates; Chromatography, High Pressure Liquid; Colorimetry; Electrochemical Techniques; Humans; Hydrogen-Ion Concentration; Hypoglycemic Agents; Linear Models; Piperidines; Reproducibility of Results; Rosiglitazone; Sensitivity and Specificity; Thiazolidinediones | 2010 |
Organic solvent-free approach to single step fabrication of Eudragit nanoparticles using Labrasol.
Topics: Anti-Infective Agents, Local; Carbamates; DNA; Drug Compounding; Excipients; Glycerides; Hypoglycemic Agents; Microscopy, Electron, Transmission; Nanoparticles; Organic Chemicals; Particle Size; Piperidines; Plasmids; Polymethacrylic Acids; Solvents; Triclosan | 2010 |
Repaglinide-gemfibrozil drug interaction: inhibition of repaglinide glucuronidation as a potential additional contributing mechanism.
Topics: Biotransformation; Carbamates; Cells, Cultured; Dose-Response Relationship, Drug; Drug Interactions; Gemfibrozil; Glucuronides; Glucuronosyltransferase; Hepatocytes; Humans; Hypoglycemic Agents; Hypolipidemic Agents; Itraconazole; Microsomes, Liver; Piperidines | 2010 |
Effects of two oral antidiabetics, pioglitazone and repaglinide, on aconitase inactivation, inflammation and oxidative/nitrosative stress in tissues under alloxan-induced hyperglycemia.
Topics: Aconitate Hydratase; Administration, Oral; Alloxan; Animals; Blood Glucose; Body Weight; Carbamates; Enzyme Activation; Hyperglycemia; Hypoglycemic Agents; Inflammation; Insulin; Lipid Peroxidation; Male; Oxidative Stress; Pioglitazone; Piperidines; Rabbits; Reactive Nitrogen Species; Thiazolidinediones | 2011 |
Effect of the CYP2C8 genotype on the pharmacokinetics and pharmacodynamics of repaglinide.
Topics: Adult; Aryl Hydrocarbon Hydroxylases; Blood Glucose; Carbamates; Cytochrome P-450 CYP2C8; Drug Interactions; Female; Genotype; Humans; Hypoglycemic Agents; Insulin; Male; Middle Aged; Piperidines; Polymorphism, Single Nucleotide | 2011 |
Effects of SLCO1B1 polymorphisms on the pharmacokinetics and pharmacodynamics of repaglinide in healthy Chinese volunteers.
Topics: Adult; Area Under Curve; Aryl Hydrocarbon Hydroxylases; Asian People; Carbamates; Cytochrome P-450 CYP2C8; Cytochrome P-450 CYP3A; Genotype; Humans; Hypoglycemic Agents; Liver-Specific Organic Anion Transporter 1; Male; Organic Anion Transporters; Piperidines; Polymerase Chain Reaction; Polymorphism, Restriction Fragment Length; Polymorphism, Single Nucleotide; Prospective Studies; Young Adult | 2011 |
2-Deoxy-D-glucose reverses the Indian red scorpion venom-induced cardiopulmonary abnormalities in anesthetized rats.
Topics: Anesthesia; Animals; Blood Glucose; Carbamates; Cardiovascular Abnormalities; Deoxyglucose; Hyperglycemia; India; Insulin; Lung Diseases; Myocardial Ischemia; Piperidines; Pulmonary Edema; Rats; Respiration; Scorpion Venoms; Ultrasonography | 2011 |
Studies on binary lipid matrix based solid lipid nanoparticles of repaglinide: in vitro and in vivo evaluation.
Topics: Administration, Oral; Animals; Biological Availability; Blood Glucose; Calorimetry, Differential Scanning; Carbamates; Chromatography, High Pressure Liquid; Diabetes Mellitus, Experimental; Drug Carriers; Drug Stability; Drug Storage; Hypoglycemic Agents; Lipids; Male; Microscopy, Electron, Transmission; Nanoparticles; Particle Size; Piperidines; Rats; Rats, Wistar; Solubility; Surface Properties; X-Ray Diffraction | 2011 |
In vivo and cytotoxicity evaluation of repaglinide-loaded binary solid lipid nanoparticles after oral administration to rats.
Topics: Animals; Biological Availability; Blood Glucose; Carbamates; Cell Survival; Cells, Cultured; Chromatography, High Pressure Liquid; Diabetes Mellitus, Experimental; Drug Carriers; Drug Stability; Hypoglycemic Agents; Lipids; Macrophages, Peritoneal; Male; Microscopy, Electron, Transmission; Nanoparticles; Particle Size; Phase Transition; Piperidines; Rats; Rats, Wistar; Solubility; Surface Properties | 2011 |
Hydrogels based on interpenetrating network of chitosan and polyvinyl pyrrolidone for pH-sensitive delivery of repaglinide.
Topics: Adhesiveness; Animals; Calorimetry, Differential Scanning; Carbamates; Chemistry, Pharmaceutical; Chitosan; Cross-Linking Reagents; Crystallography, X-Ray; Delayed-Action Preparations; Diffusion; Drug Carriers; Drug Compounding; Gastric Juice; Glutaral; Hydrogels; Hydrogen-Ion Concentration; Hypoglycemic Agents; Kinetics; Microscopy, Electron, Scanning; Piperidines; Povidone; Powder Diffraction; Rats; Solubility; Spectroscopy, Fourier Transform Infrared; Surface Properties; Technology, Pharmaceutical; Wettability | 2011 |
Hypersensitivity to repaglinide.
Topics: Carbamates; Cyclohexanes; Diabetes Mellitus, Type 2; Drug Hypersensitivity; Erythema; Exanthema; Humans; Hypoglycemic Agents; Male; Middle Aged; Nateglinide; Patch Tests; Phenylalanine; Piperidines | 2011 |
Lipid nanocarriers (GeluPearl) containing amphiphilic lipid Gelucire 50/13 as a novel stabilizer: fabrication, characterization and evaluation for oral drug delivery.
Topics: Administration, Oral; Animals; Blood Glucose; Calorimetry, Differential Scanning; Carbamates; Diabetes Mellitus, Experimental; Diglycerides; Drug Carriers; Drug Delivery Systems; Drug Stability; Fats; Feasibility Studies; Glucose Tolerance Test; Lipids; Nanoparticles; Nanotechnology; Oils; Particle Size; Piperidines; Rats; Surface-Active Agents | 2011 |
NAMPT -3186C/T polymorphism affects repaglinide response in Chinese patients with Type 2 diabetes mellitus.
Topics: Adult; Aged; Alleles; Asian People; Carbamates; Cholesterol; Control Groups; Diabetes Mellitus, Type 2; Female; Genetic Predisposition to Disease; Genotype; Humans; Hypoglycemic Agents; Insulin; Male; Middle Aged; Nicotinamide Phosphoribosyltransferase; Piperidines; Polymorphism, Genetic; Polymorphism, Single Nucleotide; Treatment Outcome | 2011 |
Exenatide improves weight loss insulin sensitivity and β-cell function following administration to a type 2 diabetic HIV patient on antiretroviral therapy.
Topics: Adipose Tissue; Antiretroviral Therapy, Highly Active; Carbamates; Diabetes Mellitus, Type 2; Drug Therapy, Combination; Exenatide; HIV Infections; Humans; Hypoglycemic Agents; Insulin Resistance; Insulin-Secreting Cells; Male; Metformin; Middle Aged; Peptides; Piperidines; Venoms; Waist Circumference; Weight Loss | 2011 |
Evaluation of CYP2C8 inhibition in vitro: utility of montelukast as a selective CYP2C8 probe substrate.
Topics: Acetates; Amodiaquine; Aryl Hydrocarbon Hydroxylases; Binding Sites; Carbamates; Cyclopropanes; Cytochrome P-450 CYP2C8; Drug Interactions; Humans; Microsomes, Liver; Paclitaxel; Piperidines; Quinolines; Rosiglitazone; Sensitivity and Specificity; Substrate Specificity; Sulfides; Thiazolidinediones | 2011 |
Transfer of repaglinide in the dually perfused human placenta and the role of organic anion transporting polypeptides (OATPs).
Topics: Carbamates; Chromatography, Liquid; Female; Humans; Hypoglycemic Agents; In Vitro Techniques; Maternal-Fetal Exchange; Organic Anion Transporters; Perfusion; Piperidines; Placenta; Polymorphism, Single Nucleotide; Pregnancy; Tandem Mass Spectrometry | 2011 |
Importance of the Kir6.2 N-terminus for the interaction of glibenclamide and repaglinide with the pancreatic K(ATP) channel.
Topics: Animals; ATP-Binding Cassette Transporters; Binding Sites; Carbamates; Glyburide; HEK293 Cells; Humans; Hypoglycemic Agents; Pancreas; Patch-Clamp Techniques; Piperidines; Potassium Channels, Inwardly Rectifying; Protein Binding; Rats; Receptors, Drug; Sulfonylurea Receptors | 2012 |
Novel anti-inflammatory effects of repaglinide in rodent models of inflammation.
Topics: Animals; Anti-Inflammatory Agents; Carbamates; Chemokine CCL2; Dinitrofluorobenzene; Ear; Erythrocytes; Foot; Hypersensitivity, Delayed; Immunologic Factors; Lipopolysaccharides; Male; Mice; Mice, Inbred ICR; Piperidines; Pneumonia; Sheep; Tumor Necrosis Factor-alpha | 2011 |
From evidence assessments to coverage decisions?: the case example of glinides in Germany.
Topics: Carbamates; Cost Control; Cost-Benefit Analysis; Costs and Cost Analysis; Cyclohexanes; Diabetes Mellitus; Eligibility Determination; Evidence-Based Medicine; Germany; Health Care Reform; Health Policy; Humans; Hypoglycemic Agents; Insurance Coverage; Nateglinide; National Health Programs; Phenylalanine; Piperidines; Prescription Drugs; Reimbursement Mechanisms; Technology Assessment, Biomedical | 2012 |
Effects of efonidipine on the pharmacokinetics and pharmacodynamics of repaglinide: possible role of CYP3A4 and P-glycoprotein inhibition by efonidipine.
Topics: Animals; Antihypertensive Agents; Area Under Curve; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biocatalysis; Biological Availability; Blood Glucose; Carbamates; Cell Line, Tumor; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dihydropyridines; Drug Interactions; Humans; Hypoglycemic Agents; Ketoconazole; Male; Models, Biological; Nitrophenols; Organophosphorus Compounds; Pharmacological Phenomena; Piperidines; Rats; Rats, Sprague-Dawley; Rhodamine 123 | 2012 |
Influence of atorvastatin on the pharmacodynamic and pharmacokinetic activity of repaglinide in rats and rabbits.
Topics: Animals; Atorvastatin; Blood Glucose; Carbamates; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Diabetes Mellitus, Experimental; Drug Interactions; Heptanoic Acids; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypoglycemic Agents; Piperidines; Pyrroles; Rabbits; Rats | 2012 |
Evaluation of exposure change of nonrenally eliminated drugs in patients with chronic kidney disease using physiologically based pharmacokinetic modeling and simulation.
Topics: Area Under Curve; Carbamates; Chronic Disease; Computer Simulation; Drug Interactions; Humans; Ketolides; Kidney Diseases; Models, Biological; Piperazines; Piperidines; Purines; Sildenafil Citrate; Sulfones | 2012 |
In vitro and in vivo studies on a novel solid dispersion of repaglinide using polyvinylpyrrolidone as the carrier.
Topics: Animals; Biological Availability; Calorimetry, Differential Scanning; Carbamates; Chromatography, High Pressure Liquid; Drug Carriers; Drug Compounding; Drug Interactions; Gastric Mucosa; Hydrophobic and Hydrophilic Interactions; Hypoglycemic Agents; Intestinal Absorption; Intestinal Mucosa; Male; Microscopy, Polarization; Molecular Structure; Piperidines; Povidone; Rats; Rats, Wistar; Solubility; Spectroscopy, Fourier Transform Infrared; Tandem Mass Spectrometry; X-Ray Diffraction | 2012 |
The pharmacokinetics and hepatic disposition of repaglinide in pigs: mechanistic modeling of metabolism and transport.
Topics: Animals; Biological Transport; Carbamates; Drug Interactions; Hepatocytes; Liver; Microsomes, Liver; Piperidines; Swine | 2012 |
Effect of genetic polymorphism of UCP2-866 G/A on repaglinide response in Chinese patients with type 2 diabetes.
Topics: Adult; Aged; Alleles; Asian People; Blood Glucose; Carbamates; Diabetes Mellitus, Type 2; DNA Primers; Female; Genotype; Humans; Hypoglycemic Agents; Insulin; Insulin-Secreting Cells; Ion Channels; Male; Middle Aged; Mitochondrial Proteins; Pancreatic Function Tests; Piperidines; Polymerase Chain Reaction; Uncoupling Protein 2 | 2012 |
A comprehensive assessment of repaglinide metabolic pathways: impact of choice of in vitro system and relative enzyme contribution to in vitro clearance.
Topics: Aryl Hydrocarbon Hydroxylases; Carbamates; Cytochrome P-450 CYP2C8; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Drug Interactions; Glucuronides; Hepatocytes; Humans; Hypoglycemic Agents; Kinetics; Metabolic Networks and Pathways; Microsomes, Liver; Piperidines | 2012 |
Preparation, characterization and in vivo evaluation of antihyperglycemic activity of microwave generated repaglinide solid dispersion.
Topics: Animals; Blood Glucose; Calorimetry, Differential Scanning; Carbamates; Female; Hypoglycemic Agents; Male; Microwaves; Piperidines; Poloxamer; Rats; Rats, Wistar; Solubility; Spectroscopy, Fourier Transform Infrared; X-Ray Diffraction | 2012 |
Oxidative/nitrosative stress and protein damages in aqueous humor of hyperglycemic rabbits: effects of two oral antidiabetics, pioglitazone and repaglinide.
Topics: Animals; Antioxidants; Aqueous Humor; Carbamates; Diabetes Mellitus, Experimental; Glutathione Peroxidase; Hyperglycemia; Hypoglycemic Agents; Lipid Peroxidation; Male; Oxidative Stress; Pioglitazone; Piperidines; Rabbits; Thiazolidinediones | 2012 |
Discrepancies among consensus documents, guidelines, clinical practice and the legal framework for the treatment of type 2 diabetes mellitus patients.
Topics: Acidosis, Lactic; Aged; Carbamates; Consensus Development Conferences as Topic; Contraindications; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Disease Management; Drug Utilization; Endocrinology; Female; Follow-Up Studies; Glomerular Filtration Rate; Hospital Departments; Humans; Hypoglycemic Agents; Male; Metformin; Middle Aged; Nephrology; Piperidines; Practice Guidelines as Topic; Primary Health Care; Professional Practice; Societies, Medical; Spain; Sulfonylurea Compounds | 2012 |
Analysis of repaglinide enantiomers in pharmaceutical formulations by capillary electrophoresis using 2,6-di-o-methyl-β-cyclodextrin as a chiral selector.
Topics: beta-Cyclodextrins; Carbamates; Drug Contamination; Electrophoresis, Capillary; Hydrogen-Ion Concentration; Limit of Detection; Linear Models; Piperidines; Reproducibility of Results; Stereoisomerism; Tablets | 2012 |
Use of mechanistic modeling to assess interindividual variability and interspecies differences in active uptake in human and rat hepatocytes.
Topics: Angiotensin II Type 1 Receptor Blockers; Animals; Antihypertensive Agents; Benzimidazoles; Benzoates; Biological Transport; Bosentan; Carbamates; Dose-Response Relationship, Drug; Drug Interactions; Fluorobenzenes; Hepatocytes; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypoglycemic Agents; Kinetics; Models, Biological; Organic Anion Transporters; Piperidines; Pravastatin; Pyrimidines; Quinolines; Rats; Rosuvastatin Calcium; Species Specificity; Sulfonamides; Telmisartan; Tetrazoles; Valine; Valsartan | 2012 |
Validated stability-indicating spectrofluorimetric method with enhanced sensitivity for determination of repaglinide in tablets.
Topics: Carbamates; Drug Stability; Linear Models; Methanol; Piperidines; Solvents; Spectrometry, Fluorescence; Sulfuric Acids; Tablets; Temperature; Time Factors | 2012 |
Effect of lipid matrix on repaglinide-loaded solid lipid nanoparticles for oral delivery.
Topics: Administration, Oral; Calorimetry, Differential Scanning; Carbamates; Chemistry, Pharmaceutical; Delayed-Action Preparations; Drug Carriers; Drug Compounding; Drug Stability; Excipients; Fatty Acids; Glycerides; Humidity; Hypoglycemic Agents; Kinetics; Lipids; Microscopy, Electron, Transmission; Nanoparticles; Nanotechnology; Piperidines; Poloxamer; Solubility; Stearic Acids; Technology, Pharmaceutical; Temperature; Triglycerides | 2010 |
LC-MS/MS-ESI method for simultaneous quantitation of metformin and repaglinidie in rat plasma and its application to pharmacokinetic study in rats.
Topics: Animals; Carbamates; Chromatography, Liquid; Drug Stability; Linear Models; Male; Metformin; Piperidines; Rats; Rats, Sprague-Dawley; Reproducibility of Results; Sensitivity and Specificity; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry | 2013 |
Analysis of the repaglinide concentration increase produced by gemfibrozil and itraconazole based on the inhibition of the hepatic uptake transporter and metabolic enzymes.
Topics: Area Under Curve; Aryl Hydrocarbon Hydroxylases; Biotransformation; Carbamates; Computer Simulation; Cytochrome P-450 CYP2C8; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Drug Interactions; Enzyme Inhibitors; Gemfibrozil; Glucuronides; Humans; Hypoglycemic Agents; Itraconazole; Least-Squares Analysis; Liver; Liver-Specific Organic Anion Transporter 1; Models, Biological; Nonlinear Dynamics; Organic Anion Transporters; Piperidines | 2013 |
Calaxin drives sperm chemotaxis by Ca²⁺-mediated direct modulation of a dynein motor.
Topics: Animals; Calcium Signaling; Carbamates; Chemotaxis; Ciona intestinalis; Dyneins; Intracellular Calcium-Sensing Proteins; Male; Microtubules; Models, Biological; Molecular Motor Proteins; Piperidines; Sperm Motility; Sperm Tail; Spermatozoa | 2012 |
Applications of minimal physiologically-based pharmacokinetic models.
Topics: Anti-Bacterial Agents; Antibodies, Monoclonal; beta-Lactams; Biological Availability; Carbamates; Codeine; Humans; Kinetics; Liver; Midazolam; Models, Biological; Piperidines; Regional Blood Flow; Verapamil | 2012 |
Effect of hypoglycemic agents on ischemic preconditioning in patients with type 2 diabetes and symptomatic coronary artery disease.
Topics: Adamantane; Aged; Carbamates; Coronary Artery Disease; Diabetes Mellitus, Type 2; Female; Humans; Hypoglycemic Agents; Ischemic Preconditioning; Male; Middle Aged; Nitriles; Piperidines; Prospective Studies; Pyrrolidines; Vildagliptin | 2013 |
Mechanistic modeling to predict the transporter- and enzyme-mediated drug-drug interactions of repaglinide.
Topics: Aryl Hydrocarbon Hydroxylases; Biological Transport, Active; Carbamates; Cell Line; Cytochrome P-450 CYP2C8; Drug Interactions; Gemfibrozil; Hepatocytes; Humans; Hypoglycemic Agents; Hypolipidemic Agents; Liver-Specific Organic Anion Transporter 1; Models, Biological; Organic Anion Transporters; Piperidines | 2013 |
A study on ethosomes as mode for transdermal delivery of an antidiabetic drug.
Topics: Administration, Cutaneous; Animals; Carbamates; Drug Carriers; Drug Delivery Systems; Hypoglycemic Agents; Organ Culture Techniques; Piperidines; Rats; Rats, Wistar; Skin Absorption | 2013 |
Quantitative prediction of repaglinide-rifampicin complex drug interactions using dynamic and static mechanistic models: delineating differential CYP3A4 induction and OATP1B1 inhibition potential of rifampicin.
Topics: Carbamates; Cytochrome P-450 CYP3A; Drug Interactions; Enzyme Induction; Humans; Liver-Specific Organic Anion Transporter 1; Models, Theoretical; Organic Anion Transporters; Piperidines; Rifampin | 2013 |
Severe thrombocytopenia due to repaglinide in a patient with type 2 diabetes.
Topics: Aged; Carbamates; Diabetes Mellitus, Type 2; Humans; Male; Piperidines; Thrombocytopenia | 2013 |
Influence of CYP2C8 polymorphisms on the hydroxylation metabolism of paclitaxel, repaglinide and ibuprofen enantiomers in vitro.
Topics: Antineoplastic Agents, Phytogenic; Aryl Hydrocarbon Hydroxylases; Baculoviridae; Carbamates; Cyclooxygenase Inhibitors; Cytochrome P-450 CYP2C8; Cytochromes b5; Genetic Vectors; Genome-Wide Association Study; Humans; Hydroxylation; Hypoglycemic Agents; Ibuprofen; Liver; Paclitaxel; Piperidines; Polymorphism, Genetic | 2013 |
Coamorphous repaglinide-saccharin with enhanced dissolution.
Topics: Calorimetry, Differential Scanning; Carbamates; Chemistry, Pharmaceutical; Crystallization; Hypoglycemic Agents; Piperidines; Powder Diffraction; Saccharin; Solubility; Spectroscopy, Fourier Transform Infrared; X-Ray Diffraction | 2013 |
The role of hepatic transport and metabolism in the interactions between pravastatin or repaglinide and two rOatp inhibitors in rats.
Topics: Animals; Carbamates; Cells, Cultured; Diphenhydramine; Drug Interactions; Hepatocytes; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypoglycemic Agents; Male; Microsomes, Liver; Organic Anion Transporters; Piperidines; Pravastatin; Rats; Rats, Sprague-Dawley; Spironolactone | 2013 |
Design and evaluation of self-nanoemulsifying pellets of repaglinide.
Topics: Animals; Carbamates; Chromatography, High Pressure Liquid; Drug Design; Emulsions; Hydrogen-Ion Concentration; Hypoglycemic Agents; Microscopy, Electron, Scanning; Nanostructures; Piperidines; Powder Diffraction; Rats; Solubility; Surface-Active Agents | 2013 |
Optimization and charaterization of repaglinide biodegradable polymeric nanoparticle loaded transdermal patchs: in vitro and in vivo studies.
Topics: Animals; Biocompatible Materials; Biological Availability; Blood Glucose; Carbamates; In Vitro Techniques; Insulin; Kinetics; Lactic Acid; Nanoparticles; Particle Size; Permeability; Piperidines; Polyesters; Polymers; Rats, Wistar; Skin Absorption; Spectroscopy, Fourier Transform Infrared; Transdermal Patch | 2013 |
Spray-dried gastroretentive floating microparticles: preparation and in vitro evaluation.
Topics: Calorimetry, Differential Scanning; Carbamates; Chemistry, Pharmaceutical; Drug Delivery Systems; Particle Size; Piperidines; Polymers; Solubility; Spectroscopy, Fourier Transform Infrared; Technology, Pharmaceutical | 2013 |
Deaths in trials should always be reported.
Topics: Carbamates; Clinical Trials as Topic; Humans; Hypoglycemic Agents; Mortality; Piperidines; Sulfonylurea Compounds | 2013 |
Liquid chromatography-tandem mass spectrometry simultaneous determination of repaglinide and metformin in human plasma and its application to bioequivalence study.
Topics: Administration, Oral; Adolescent; Adult; Area Under Curve; Carbamates; Chromatography, Liquid; Drug Stability; Female; Humans; Hypoglycemic Agents; Male; Metformin; Middle Aged; Piperidines; Tandem Mass Spectrometry; Therapeutic Equivalency; Young Adult | 2013 |
Effects of dipeptidyl peptidase-4 inhibitors in a type 2 diabetes patient with failure of glucagon-like peptide-1 receptor agonists.
Topics: Blood Glucose; Carbamates; Diabetes Mellitus, Type 2; Dipeptidyl-Peptidase IV Inhibitors; Drug Therapy, Combination; Exenatide; Fasting; Female; Glucagon-Like Peptide-1 Receptor; Humans; Hypoglycemic Agents; Insulin Glargine; Insulin, Long-Acting; Metformin; Middle Aged; Peptides; Piperidines; Pyrazines; Receptors, Glucagon; Sitagliptin Phosphate; Treatment Failure; Triazoles; Venoms | 2014 |
Interindividual variability in hepatic organic anion-transporting polypeptides and P-glycoprotein (ABCB1) protein expression: quantification by liquid chromatography tandem mass spectroscopy and influence of genotype, age, and sex.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Alleles; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; Carbamates; Child; Child, Preschool; Chromatography, Liquid; Female; Fluorobenzenes; Haplotypes; Hepatocytes; Humans; Individuality; Infant; Liver; Male; Middle Aged; Organic Anion Transporters; Piperidines; Polymorphism, Single Nucleotide; Pyrimidines; Rosuvastatin Calcium; Sulfonamides; Tandem Mass Spectrometry; Young Adult | 2014 |
In vitro inhibition of metabolism but not transport of gliclazide and repaglinide by Cree medicinal plant extracts.
Topics: Aryl Hydrocarbon Hydroxylases; Caco-2 Cells; Carbamates; Drug Interactions; Gliclazide; Glucuronosyltransferase; Humans; Hypoglycemic Agents; Intestinal Absorption; Medicine, Traditional; Microsomes, Liver; Piperidines; Plant Extracts; Plants, Medicinal; Quebec; Stilbenes | 2013 |
Effects of nifedipine on the pharmacokinetics of repaglinide in rats: possible role of CYP3A4 and P-glycoprotein inhibition by nifedipine.
Topics: Administration, Oral; Animals; Area Under Curve; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Availability; Biomarkers; Biotransformation; Blood Glucose; Calcium Channel Blockers; Carbamates; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Inhibitors; Humans; Hypoglycemic Agents; Injections, Intravenous; Male; Nifedipine; Piperidines; Polypharmacy; Rats; Rats, Sprague-Dawley | 2013 |
Possible anticancer activity of rosuvastatine, doxazosin, repaglinide and oxcarbazepin.
Topics: Animals; Anticonvulsants; Antihypertensive Agents; Antineoplastic Agents; Carbamates; Carbamazepine; Carcinoma, Ehrlich Tumor; Cell Proliferation; Cell Survival; Doxazosin; Fluorobenzenes; HeLa Cells; Hep G2 Cells; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypoglycemic Agents; Inhibitory Concentration 50; MCF-7 Cells; Oxcarbazepine; Piperidines; Pyrimidines; Rosuvastatin Calcium; Sulfonamides | 2014 |
Controlled release of metformin hydrochloride and repaglinide from sandwiched osmotic pump tablet.
Topics: Animals; Carbamates; Delayed-Action Preparations; Dogs; Drug Combinations; Hypoglycemic Agents; Male; Metformin; Osmosis; Piperidines; Tablets | 2014 |
Reduced physiologically-based pharmacokinetic model of repaglinide: impact of OATP1B1 and CYP2C8 genotype and source of in vitro data on the prediction of drug-drug interaction risk.
Topics: Carbamates; Computer Simulation; Cytochrome P-450 CYP2C8; Drug Interactions; Genotype; Humans; Hypoglycemic Agents; Liver-Specific Organic Anion Transporter 1; Models, Biological; Monte Carlo Method; Organic Anion Transporters; Piperidines; Polymorphism, Genetic; Prospective Studies | 2014 |
Preparation and evaluation of a controlled drug release of repaglinide through matrix pellets: in vitro and in vivo studies.
Topics: Administration, Oral; Animals; Blood Glucose; Carbamates; Cellulose; Diabetes Mellitus, Experimental; Drug Evaluation, Preclinical; Drug Implants; Hypoglycemic Agents; Lactose; Male; Piperidines; Rats; Rats, Wistar | 2014 |
Effects of nateglinide and repaglinide administered intracerebroventricularly on the CA3 hippocampal neuronal cell death and hyperglycemia induced by kainic acid in mice.
Topics: Animals; Blood Glucose; CA3 Region, Hippocampal; Carbamates; Cell Death; Corticosterone; Cyclohexanes; Excitatory Amino Acid Agonists; Hypoglycemic Agents; Infusions, Intraventricular; Insulin; Kainic Acid; Male; Mice; Mice, Inbred ICR; Nateglinide; Neurons; Phenylalanine; Piperidines | 2014 |
Anakinra treatment in patients with gout and type 2 diabetes.
Topics: Aged; Aged, 80 and over; Allopurinol; Anti-Inflammatory Agents, Non-Steroidal; Antirheumatic Agents; Blood Glucose; Carbamates; Colchicine; Diabetes Mellitus, Type 2; Febuxostat; Glycated Hemoglobin; Gout; Gout Suppressants; Humans; Hyperuricemia; Hypoglycemic Agents; Insulin; Interleukin 1 Receptor Antagonist Protein; Metformin; Middle Aged; Piperidines; Treatment Outcome; Uric Acid | 2015 |
Nasal polysaccharides-glucose regulator microparticles: optimization, tolerability and antidiabetic activity in rats.
Topics: Administration, Intranasal; Animals; Blood Glucose; Carbamates; Diabetes Mellitus, Experimental; Drug Delivery Systems; Hypoglycemic Agents; Male; Nasal Mucosa; Piperidines; Rats | 2014 |
[Determination of R(-)- isomer in repaglinide tablets by capillary electrophoresis].
Topics: Carbamates; Electrophoresis, Capillary; Piperidines; Stereoisomerism; Tablets | 2014 |
[Simultaneous determination of repaglinide and pravastatin sodium in rat plasma by LC-ms/MS and its application on pharmacokinetic interactions study].
Topics: Administration, Oral; Animals; Carbamates; Chromatography, High Pressure Liquid; Drug Interactions; Male; Piperidines; Pravastatin; Random Allocation; Rats; Rats, Sprague-Dawley; Reproducibility of Results; Sensitivity and Specificity; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry | 2014 |
In vitro and in vivo evaluation of novel interpenetrated polymer network microparticles containing repaglinide.
Topics: Alginates; Animals; Carbamates; Delayed-Action Preparations; Drug Carriers; Glucuronic Acid; Hexuronic Acids; Hypoglycemic Agents; Microspheres; Pancreas; Particle Size; Piperidines; Plant Gums; Polymers; Rats; Rats, Wistar; Sterculia | 2014 |
Nanocomplexes of an insulinotropic drug: optimization, microparticle formation, and antidiabetic activity in rats.
Topics: Administration, Intranasal; Animals; Blood Glucose; Carbamates; Cell Line; Cell Survival; Chemistry, Pharmaceutical; Diabetes Mellitus, Experimental; Drug Carriers; Hypoglycemic Agents; Male; Microspheres; Nasal Mucosa; Piperidines; Rats, Wistar | 2014 |
Matrix tablets for sustained release of repaglinide: Preparation, pharmacokinetics and hypoglycemic activity in beagle dogs.
Topics: Animals; Blood Glucose; Carbamates; Delayed-Action Preparations; Dogs; Drug Liberation; Hypoglycemic Agents; Piperidines; Tablets | 2015 |
Preparation, characterization and in vivo evaluation of formulation of repaglinide with hydroxypropyl-β-cyclodextrin.
Topics: 2-Hydroxypropyl-beta-cyclodextrin; Animals; Area Under Curve; beta-Cyclodextrins; Biological Availability; Calorimetry, Differential Scanning; Carbamates; Chemistry, Pharmaceutical; Chromatography, Liquid; Dogs; Freeze Drying; Hypoglycemic Agents; Magnetic Resonance Spectroscopy; Piperidines; Solubility; Tandem Mass Spectrometry; X-Ray Diffraction | 2014 |
Metformin in combination with various insulin secretagogues in type 2 diabetes and associated risk of cardiovascular morbidity and mortality--a retrospective nationwide study.
Topics: Aged; Carbamates; Cardiovascular Diseases; Denmark; Diabetes Mellitus, Type 2; Drug Therapy, Combination; Female; Gliclazide; Glipizide; Glyburide; Humans; Hypoglycemic Agents; Male; Metformin; Middle Aged; Morbidity; Myocardial Infarction; Piperidines; Registries; Retrospective Studies; Risk Factors; Stroke; Sulfonylurea Compounds; Tolbutamide | 2015 |
Delayed hypoglycemia induced by repaglinide in a frail elderly adult with diabetes mellitus.
Topics: Aged, 80 and over; Carbamates; Diabetes Mellitus, Type 2; Frail Elderly; Humans; Hypoglycemia; Hypoglycemic Agents; Male; Piperidines | 2014 |
[New medications for patients with type 2 diabetes].
Topics: Carbamates; Diabetes Mellitus, Type 2; Dipeptidyl-Peptidase IV Inhibitors; Drug Therapy, Combination; Glucagon-Like Peptide 1; Glycoside Hydrolase Inhibitors; Humans; Hypoglycemic Agents; Incretins; Piperidines | 2014 |
Comparative cardiovascular safety of insulin secretagogues following hospitalization for ischemic heart disease among type 2 diabetes patients: a cohort study.
Topics: Aged; Aged, 80 and over; Alberta; Blue Cross Blue Shield Insurance Plans; Carbamates; Cardiovascular Diseases; Cohort Studies; Databases, Factual; Diabetes Mellitus, Type 2; Diabetic Angiopathies; Diabetic Cardiomyopathies; Female; Gliclazide; Glyburide; Hospitalization; Humans; Hypoglycemic Agents; Male; Myocardial Ischemia; Piperidines; Proportional Hazards Models; Retrospective Studies; Risk; Universal Health Insurance | 2015 |
Ultra rapidly dissolving repaglinide nanosized crystals prepared via bottom-up and top-down approach: influence of food on pharmacokinetics behavior.
Topics: Animals; Biological Availability; Carbamates; Food-Drug Interactions; Hypoglycemic Agents; Male; Nanoparticles; Piperidines; Rats; Rats, Wistar | 2015 |
Bioanalytical method for in vitro metabolism study of repaglinide using 96-blade thin-film solid-phase microextraction and LC-MS/MS.
Topics: Carbamates; Chromatography, Liquid; Humans; Hypoglycemic Agents; In Vitro Techniques; Piperidines; Solid Phase Microextraction; Tandem Mass Spectrometry | 2015 |
A sensitive chemiluminescent immunoassay for point-of-care testing of repaglinide in natural dietary supplements and serum.
Topics: Carbamates; Chromatography, High Pressure Liquid; Dietary Supplements; Humans; Immunoassay; Limit of Detection; Luminescence; Piperidines; Point-of-Care Systems | 2015 |
In vitro evaluation of hypoglycemic agents to target human islet amyloid polypeptide: a key protein involved in amyloid deposition and beta-cell loss.
Topics: Amyloid; Amyloidosis; Animals; Carbamates; Cell Survival; Chromans; Circular Dichroism; Glyburide; Humans; Hypoglycemic Agents; Insulin-Secreting Cells; Islet Amyloid Polypeptide; Piperidines; Protein Structure, Secondary; Rats; Thiazolidinediones; Troglitazone | 2015 |
Co-administration of paroxetine increased the systemic exposure of pravastatin in diabetic rats due to the decrease in liver distribution.
Topics: Administration, Intravenous; Administration, Oral; Animals; Body Fluids; Carbamates; Cell Separation; Diabetes Mellitus, Experimental; Diet, High-Fat; Disease Models, Animal; Feces; Hepatocytes; Intestinal Absorption; Liver; Male; Paroxetine; Piperidines; Pravastatin; Rats, Sprague-Dawley; Tissue Distribution | 2015 |
Getting to goal in newly diagnosed type 2 diabetes using combination drug "subtraction therapy".
Topics: Adult; Aged; Aged, 80 and over; Carbamates; Diabetes Mellitus, Type 2; Drug Therapy, Combination; Female; Follow-Up Studies; Glycated Hemoglobin; Goals; Humans; Hypoglycemia; Hypoglycemic Agents; Male; Metformin; Middle Aged; Pioglitazone; Piperidines; Thiazolidinediones; Treatment Outcome | 2015 |
Repaglinide-loaded solid lipid nanoparticles: effect of using different surfactants/stabilizers on physicochemical properties of nanoparticles.
Topics: Calorimetry, Differential Scanning; Carbamates; Delayed-Action Preparations; Drug Compounding; Drug Stability; Humans; Hypoglycemic Agents; Nanoparticles; Particle Size; Piperidines; Surface-Active Agents | 2015 |
Quantitation of repaglinide and metabolites in mouse whole-body thin tissue sections using droplet-based liquid microjunction surface sampling-high-performance liquid chromatography-electrospray ionization tandem mass spectrometry.
Topics: Animals; Carbamates; Chromatography, High Pressure Liquid; Hypoglycemic Agents; Male; Mice; Mice, Inbred BALB C; Microinjections; Microtomy; Piperidines; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry; Tissue Distribution | 2016 |
Prolonged hypoglycemia after a suicidal ingestion of repaglinide with unexpected slow plasma elimination.
Topics: Adolescent; Blood Glucose; Carbamates; Chromatography, Liquid; Drug Overdose; Female; Half-Life; Humans; Hypoglycemia; Hypoglycemic Agents; Insulin; Piperidines; Tandem Mass Spectrometry | 2016 |
Activating transcription factor 6 derepression mediates neuroprotection in Huntington disease.
Topics: Activating Transcription Factor 6; Animals; Carbamates; CHO Cells; Corpus Striatum; Cricetulus; Disease Models, Animal; HEK293 Cells; HeLa Cells; Humans; Huntington Disease; Kv Channel-Interacting Proteins; Mice; Neurons; Piperidines; Repressor Proteins; Signal Transduction | 2016 |
Comparative Study of the Antioxidant Effects of Metformin, Glibenclamide, and Repaglinide in Alloxan-Induced Diabetic Rats.
Topics: Alloxan; Animals; Antioxidants; Biomarkers; Blood Glucose; Carbamates; Catalase; Diabetes Complications; Diabetes Mellitus, Experimental; Glutathione; Glyburide; Hypoglycemic Agents; Lipid Peroxidation; Male; Malondialdehyde; Metformin; Oxidative Stress; Piperidines; Rats; Superoxide Dismutase | 2016 |
Insulinotropic compounds decrease endothelial cell survival.
Topics: Benzofurans; Carbamates; Cell Proliferation; Cell Survival; Cells, Cultured; Dimethyl Sulfoxide; Glucose; Glyburide; Human Umbilical Vein Endothelial Cells; Humans; Hypoglycemic Agents; Imidazoles; Indoles; Nitric Oxide; Piperidines; Vascular Endothelial Growth Factor A | 2016 |
Enhancement of solubility and antidiabetic effects of Repaglinide using spray drying technique in STZ-induced diabetic rats.
Topics: Animals; Calorimetry, Differential Scanning; Carbamates; Diabetes Mellitus, Experimental; Hypoglycemic Agents; Piperidines; Rats; Solubility; Spectroscopy, Fourier Transform Infrared | 2017 |
Joint effects of diabetic-related genomic loci on the therapeutic efficacy of oral anti-diabetic drugs in Chinese type 2 diabetes patients.
Topics: Administration, Oral; Adult; Alleles; Asian People; Blood Glucose; Body Mass Index; Carbamates; China; Diabetes Mellitus, Type 2; Drug Administration Schedule; Female; Genetic Loci; Genotype; Glucose Tolerance Test; Glycated Hemoglobin; Humans; Hypoglycemic Agents; Linear Models; Male; Middle Aged; Piperidines; Polymorphism, Single Nucleotide; Rosiglitazone; Thiazolidinediones | 2016 |
Clinical study of repaglinide efficacy and safety in type 2 diabetes mellitus patients with blood glucose levels inadequately controlled by sitagliptin.
Topics: Adult; Aged; Blood Glucose; Carbamates; Diabetes Mellitus, Type 2; Female; Glycated Hemoglobin; Humans; Hypoglycemic Agents; Male; Middle Aged; Piperidines; Sitagliptin Phosphate | 2016 |
Development and characterization of a novel lipohydrogel nanocarrier: repaglinide as a lipophilic model drug.
Topics: Administration, Intravenous; Animals; Blood Glucose; Carbamates; Cell Line; Cell Survival; Chitosan; Delayed-Action Preparations; Drug Carriers; Drug Compounding; Fibroblasts; Hydrogels; Hypoglycemic Agents; Lipids; Male; Mice; Nanotechnology; Particle Size; Piperidines; Polyphosphates; Rats, Sprague-Dawley; Solubility; Spectroscopy, Fourier Transform Infrared; Static Electricity; Surface Properties; Technology, Pharmaceutical | 2016 |
Altered pharmacokinetics and pharmacodynamics of repaglinide by ritonavir in rats with healthy, diabetic and impaired hepatic function.
Topics: Alloxan; Animals; Blood Glucose; Carbamates; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Diabetes Mellitus, Experimental; Drug Synergism; Male; Piperidines; Rats; Ritonavir | 2016 |
Nanoemulsion: for improved oral delivery of repaglinide.
Topics: Administration, Oral; Animals; Biopharmaceutics; Carbamates; Diabetes Mellitus, Experimental; Drug Stability; Emulsions; Hypoglycemic Agents; Lipids; Nanoparticles; Piperidines; Polysorbates; Rats; Solubility | 2016 |
Simultaneous Determination of Metformin, Glipizide, Repaglinide, and Glimepiride or Metformin and Pioglitazone by a Validated LC Method: Application in the Presence of Metformin Impurity (1-Cyanoguanidine).
Topics: Carbamates; Chromatography, High Pressure Liquid; Drug Contamination; Glipizide; Guanidines; Hypoglycemic Agents; Metformin; Pioglitazone; Piperidines; Sulfonylurea Compounds; Thiazolidinediones | 2016 |
CYP2C8-mediated interaction between repaglinide and steviol acyl glucuronide: In vitro investigations using rat and human matrices and in vivo pharmacokinetic evaluation in rats.
Topics: Animals; Carbamates; Chromatography, Liquid; Cytochrome P-450 CYP2C8; Diterpenes, Kaurane; Glucuronides; Humans; Hydroxylation; Male; Microsomes, Liver; Paclitaxel; Piperidines; Rats; Rats, Sprague-Dawley; Tandem Mass Spectrometry | 2016 |
Dissolution Rate Enhancement of Repaglinide Using Dietary Fiber as a Promising Carrier.
Topics: Carbamates; Cellulose; Chemical Phenomena; Dietary Fiber; Drug Carriers; Drug Liberation; Drug Stability; In Vitro Techniques; Piperidines; Sasa; Solubility; Tablets | 2016 |
The anti-diabetic drug repaglinide induces vasorelaxation via activation of PKA and PKG in aortic smooth muscle.
Topics: Animals; Aorta; Carbamates; Cyclic AMP-Dependent Protein Kinases; Cyclic GMP-Dependent Protein Kinases; Dose-Response Relationship, Drug; Endothelium, Vascular; Glucose; Hypoglycemic Agents; Male; Muscle, Smooth, Vascular; Phenylephrine; Piperidines; Rabbits; Signal Transduction; Vasodilation; Vasodilator Agents | 2016 |
Modeling Organic Anion-Transporting Polypeptide 1B1 Inhibition to Elucidate Interaction Risks in Early Drug Design.
Topics: Carbamates; Computer Simulation; Databases, Factual; Drug Design; Drug Interactions; HEK293 Cells; Humans; Liver-Specific Organic Anion Transporter 1; Models, Chemical; Piperidines; Risk | 2016 |
Clinical and molecular characterization of a novel INS mutation identified in patients with MODY phenotype.
Topics: Adolescent; Animals; Carbamates; Child; Diabetes Mellitus, Type 2; Female; Heterozygote; High-Throughput Nucleotide Sequencing; Humans; Insulin; Insulin-Secreting Cells; Male; Mice; Mutation; Pedigree; Piperidines; Regulatory Factor X Transcription Factors | 2016 |
Development of repaglinide microspheres using novel acetylated starches of bitter and Chinese yams as polymers.
Topics: Acetic Anhydrides; Acetylation; Carbamates; Cellulose; Dioscorea; Drug Carriers; Drug Compounding; Drug Liberation; Factor Analysis, Statistical; Hypoglycemic Agents; Kinetics; Microspheres; Particle Size; Piperidines; Plant Extracts; Pyridines; Solutions; Starch; Thermodynamics | 2017 |
Comparing the risks of hospitalized heart failure associated with glinide, sulfonylurea, and acarbose use in type 2 diabetes: A nationwide study.
Topics: Acarbose; Administration, Oral; Age Factors; Aged; Carbamates; Cohort Studies; Confidence Intervals; Databases, Factual; Diabetes Mellitus, Type 2; Female; Follow-Up Studies; Heart Failure; Hospital Mortality; Hospitalization; Humans; Hypoglycemic Agents; Incidence; Male; Middle Aged; Piperidines; Proportional Hazards Models; Retrospective Studies; Risk Assessment; Sex Factors; Sulfonylurea Compounds; Survival Rate; Taiwan | 2017 |
Phospholipid complex enriched micelles: A novel drug delivery approach for promoting the antidiabetic effect of repaglinide.
Topics: Animals; Calorimetry, Differential Scanning; Carbamates; Chemistry, Pharmaceutical; Drug Carriers; Drug Delivery Systems; Drug Stability; Hypoglycemic Agents; Male; Micelles; Microscopy, Electron, Transmission; Phospholipids; Piperidines; Poloxamer; Rats; Rats, Wistar; Spectroscopy, Fourier Transform Infrared; Tablets; X-Ray Diffraction | 2017 |
Evaluation of Pharmacokinetic Interactions Between Lesinurad, a New Selective Urate Reabsorption Inhibitor, and CYP Enzyme Substrates Sildenafil, Amlodipine, Tolbutamide, and Repaglinide.
Topics: Adult; Amlodipine; Area Under Curve; Carbamates; Cytochrome P-450 Enzyme System; Dose-Response Relationship, Drug; Drug Interactions; Gene Expression Regulation; Healthy Volunteers; Humans; In Vitro Techniques; Male; Middle Aged; Piperidines; Sildenafil Citrate; Thioglycolates; Tolbutamide; Triazoles; Young Adult | 2017 |
Estimation of ellagic acid and/or repaglinide effects on insulin signaling, oxidative stress, and inflammatory mediators of liver, pancreas, adipose tissue, and brain in insulin resistant/type 2 diabetic rats.
Topics: Animals; Antineoplastic Agents, Phytogenic; Apoptosis; Biomarkers; Brain; Carbamates; Diabetes Mellitus, Type 2; Drug Therapy, Combination; Ellagic Acid; Hyperglycemia; Hypoglycemic Agents; Inflammation Mediators; Insulin Resistance; Intra-Abdominal Fat; Liver; Male; Neurons; Oxidative Stress; Pancreas; Piperidines; Rats, Wistar | 2017 |
Dual crosslinked pectin-alginate network as sustained release hydrophilic matrix for repaglinide.
Topics: Adhesiveness; Alginates; Carbamates; Delayed-Action Preparations; Drug Carriers; Drug Liberation; Epichlorohydrin; Glucuronic Acid; Hexuronic Acids; Hydrophobic and Hydrophilic Interactions; Kinetics; Mucous Membrane; Particle Size; Pectins; Piperidines; Temperature | 2017 |
Biomedical Informatics Approaches to Identifying Drug-Drug Interactions: Application to Insulin Secretagogues.
Topics: Area Under Curve; Carbamates; Cyclohexanes; Databases, Factual; Diabetes Mellitus, Type 2; Drug Interactions; Glipizide; Glyburide; Humans; Hypoglycemia; Hypoglycemic Agents; Medical Informatics; Nateglinide; Pharmacoepidemiology; Phenylalanine; Piperidines; Sulfonylurea Compounds | 2017 |
Estimation of the Contribution of CYP2C8 and CYP3A4 in Repaglinide Metabolism by Human Liver Microsomes Under Various Buffer Conditions.
Topics: Acetates; Buffers; Carbamates; Cyclopropanes; Cytochrome P-450 CYP2C8; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inducers; Cytochrome P-450 Enzyme Inhibitors; Drug Interactions; Humans; Hypoglycemic Agents; Ketoconazole; Microsomes, Liver; Piperidines; Quinolines; Sulfides | 2017 |
Type 2 Diabetes Mellitus Treatment Patterns Across Europe: A Population-based Multi-database Study.
Topics: Aged; Carbamates; Databases, Factual; Diabetes Mellitus, Type 2; Drug Therapy, Combination; Drug Utilization; Europe; Female; Humans; Hypoglycemic Agents; Incretins; Male; Metformin; Middle Aged; Piperidines; Sulfonylurea Compounds | 2017 |
Identification, isolation, and synthesis of seven novel impurities of anti-diabetic drug Repaglinide.
Topics: Carbamates; Chromatography, High Pressure Liquid; Chromatography, Liquid; Drug Contamination; Hypoglycemic Agents; Piperidines; Spectrometry, Mass, Electrospray Ionization; Spectroscopy, Fourier Transform Infrared; Tandem Mass Spectrometry | 2018 |
The beneficial effect of repaglinide on in vitro maturation and development ability of immature mouse oocytes.
Topics: Animals; Carbamates; Cleavage Stage, Ovum; Female; In Vitro Oocyte Maturation Techniques; Metaphase; Mice; Oocytes; Piperidines | 2017 |
Identification of repaglinide as a therapeutic drug for glioblastoma multiforme.
Topics: Animals; Carbamates; Cell Survival; Disease Models, Animal; Dose-Response Relationship, Drug; Glioblastoma; Humans; Mice; Mice, Inbred C57BL; Piperidines; Structure-Activity Relationship; Tumor Cells, Cultured | 2017 |
Quantitative Analysis of Complex Drug-Drug Interactions Between Repaglinide and Cyclosporin A/Gemfibrozil Using Physiologically Based Pharmacokinetic Models With In Vitro Transporter/Enzyme Inhibition Data.
Topics: Biological Transport; Carbamates; Computer Simulation; Cyclosporine; Cytochrome P-450 CYP2C8; Cytochrome P-450 CYP2C8 Inhibitors; Cytochrome P-450 CYP3A; Drug Interactions; Enzyme Inhibitors; Gemfibrozil; Humans; Hypoglycemic Agents; Liver-Specific Organic Anion Transporter 1; Models, Biological; Piperidines | 2017 |
Quantitative Analyses of the Influence of Parameters Governing Rate-Determining Process of Hepatic Elimination of Drugs on the Magnitudes of Drug-Drug Interactions via Hepatic OATPs and CYP3A Using Physiologically Based Pharmacokinetic Models.
Topics: Adult; Bosentan; Carbamates; Computer Simulation; Cytochrome P-450 CYP3A; Drug Interactions; Hepatobiliary Elimination; Humans; Itraconazole; Liver; Male; Models, Biological; Organic Anion Transporters; Pharmaceutical Preparations; Piperidines; Rifampin; Sulfonamides; Young Adult | 2017 |
Impact of chronic unpredicted mild stress-induced depression on repaglinide fate via glucocorticoid signaling pathway.
Topics: Animals; Biosynthetic Pathways; Carbamates; Cell Line; Constitutive Androstane Receptor; Depression; Disease Models, Animal; Gene Expression Profiling; Gene Expression Regulation; Gene Regulatory Networks; Glucocorticoids; Liver; Male; Pharmacogenetics; Piperidines; Rats; Signal Transduction; Stress, Psychological | 2017 |
Explaining Ethnic Variability of Transporter Substrate Pharmacokinetics in Healthy Asian and Caucasian Subjects with Allele Frequencies of OATP1B1 and BCRP: A Mechanistic Modeling Analysis.
Topics: Asian People; Atorvastatin; ATP Binding Cassette Transporter, Subfamily G, Member 2; Carbamates; Computer Simulation; Gene Frequency; Genotype; Healthy Volunteers; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypoglycemic Agents; Liver-Specific Organic Anion Transporter 1; Models, Biological; Neoplasm Proteins; Pharmacogenomic Variants; Phenotype; Piperidines; Pravastatin; Quinolines; Rosuvastatin Calcium; White People | 2018 |
The Effects of Mitiglinide and Repaglinide on Postprandial Hyperglycemia in Patients Undergoing Methylprednisolone Pulse Therapy.
Topics: Aged; Blood Glucose; Carbamates; Diabetes Mellitus, Type 2; Female; Graves Ophthalmopathy; Humans; Hyperglycemia; Hypoglycemic Agents; Isoindoles; Male; Methylprednisolone; Middle Aged; Piperidines; Treatment Outcome | 2018 |
Evaluation of Clinical Drug Interaction Potential of Clofazimine Using Static and Dynamic Modeling Approaches.
Topics: Antitubercular Agents; Area Under Curve; Carbamates; Clofazimine; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Desipramine; Drug Interactions; Humans; Midazolam; Models, Biological; Piperidines; Tuberculosis, Multidrug-Resistant | 2018 |
Chitosan nanoparticles/cellulose nanocrystals nanocomposites as a carrier system for the controlled release of repaglinide.
Topics: Carbamates; Cellulose; Chitosan; Delayed-Action Preparations; Drug Carriers; Drug Delivery Systems; Drug Liberation; Humans; Hydrolysis; Hyperglycemia; Nanocomposites; Nanoparticles; Piperidines; Spectroscopy, Fourier Transform Infrared | 2018 |
Implications of intercorrelation between hepatic CYP3A4-CYP2C8 enzymes for the evaluation of drug-drug interactions: a case study with repaglinide.
Topics: Adult; Carbamates; Clinical Trials as Topic; Computer Simulation; Cytochrome P-450 CYP2C8; Cytochrome P-450 CYP2C8 Inhibitors; Cytochrome P-450 CYP3A; Drug Interactions; Female; Gemfibrozil; Humans; Hypoglycemic Agents; Male; Microsomes, Liver; Models, Biological; Piperidines; Young Adult | 2018 |
Development and validation of probe drug cocktails for the characterization of CYP450-mediated metabolism by human heart microsomes.
Topics: Bupropion; Butyrophenones; Carbamates; Chlorzoxazone; Cytochrome P-450 Enzyme System; Drug Evaluation, Preclinical; Ethanolamines; Humans; Lauric Acids; Microsomes; Midazolam; Myocardium; Oxazines; Piperidines; Tolbutamide | 2019 |
Inhibition of DREAM-ATF6 interaction delays onset of cognition deficit in a mouse model of Huntington's disease.
Topics: Activating Transcription Factor 6; Animals; Carbamates; Cognition Disorders; Disease Models, Animal; Hippocampus; Humans; Huntington Disease; Kv Channel-Interacting Proteins; Memory Disorders; Mice, Inbred C57BL; Mice, Transgenic; Neuronal Calcium-Sensor Proteins; Neurons; Piperidines; Rotarod Performance Test | 2018 |
Characteristics of repaglinide effects on insulin secretion.
Topics: Animals; Calcium; Carbamates; Drug Interactions; Exocytosis; Glucagon-Like Peptide 1; Guanine Nucleotide Exchange Factors; Insulin; Insulin Secretion; Insulin-Secreting Cells; Intracellular Space; Mice; Mice, Inbred C57BL; Piperidines | 2018 |
Liquid chromatography/electrospray ionization tandem mass spectrometry study of repaglinide and its forced degradation products.
Topics: Carbamates; Chromatography, High Pressure Liquid; Drug Stability; Hydrolysis; Oxidation-Reduction; Piperidines; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry | 2018 |
Repaglinide-irbesartan drug interaction: effects of SLCO1B1 polymorphism on repaglinide pharmacokinetics and pharmacodynamics in Chinese population.
Topics: Adult; Asian People; Biphenyl Compounds; Blood Glucose; Carbamates; Cells, Cultured; China; Dose-Response Relationship, Drug; Drug Interactions; Genotype; Healthy Volunteers; Humans; Imidazoles; Irbesartan; Liver-Specific Organic Anion Transporter 1; Losartan; Male; Piperidines; Polymorphism, Single Nucleotide; Tetrazoles; Valsartan; Young Adult | 2018 |
Preparation, Characterization and In Vivo Assessment of Repaglinide Nanosuspension for Oral Bioavailability Improvement.
Topics: Administration, Oral; Animals; Biological Availability; Carbamates; Drug Liberation; Drug Stability; Nanoparticles; Particle Size; Patents as Topic; Piperidines; Poloxamer; Rabbits; Solubility; Surface Properties; Suspensions | 2018 |
Repaglinide inhibits cyclosporine A-induced renal tubular toxicity\
by affecting apoptosis and \
Bax\
and \
Bcl-2\
expression
Topics: Animals; Apoptosis; bcl-2-Associated X Protein; Carbamates; Cyclosporine; Hypoglycemic Agents; Kidney; Kidney Diseases; Kidney Tubules; Male; Piperidines; Proto-Oncogene Proteins c-bcl-2; Rats, Sprague-Dawley | 2018 |
Strategies to improve the prediction accuracy of hepatic intrinsic clearance of three antidiabetic drugs: Application of the extended clearance concept and consideration of the effect of albumin on CYP2C metabolism and OATP1B-mediated hepatic uptake.
Topics: Albumins; Carbamates; Cytochrome P-450 Enzyme System; Glyburide; HEK293 Cells; Hepatocytes; Humans; Hypoglycemic Agents; Liver; Liver-Specific Organic Anion Transporter 1; Metabolic Clearance Rate; Microsomes, Liver; Models, Biological; Nateglinide; Piperidines; Solute Carrier Organic Anion Transporter Family Member 1B3 | 2018 |
Side effects of frequently used oral antidiabetics on wound healing in vitro.
Topics: Administration, Oral; Apoptosis; Carbamates; Caspases; Cell Line; Endopeptidases; Fibroblasts; Gelatinases; Glyburide; Humans; Hypoglycemic Agents; Keratinocytes; Membrane Proteins; Metformin; Piperidines; Receptors, CXCR4; Serine Endopeptidases; Sitagliptin Phosphate; Wound Healing | 2019 |
Hypoglycemic side effects of sulfonylureas and repaglinide in ageing patients - knowledge and self-management.
Topics: Aged; Aged, 80 and over; Aging; Carbamates; Diabetes Mellitus, Type 2; Drug Therapy, Combination; Female; Health Knowledge, Attitudes, Practice; Humans; Hypoglycemia; Hypoglycemic Agents; Male; Middle Aged; Piperidines; Self-Management; Sulfonylurea Compounds | 2018 |
Accounting for inter-correlation between enzyme abundance: a simulation study to assess implications on global sensitivity analysis within physiologically-based pharmacokinetics.
Topics: Biological Availability; Carbamates; Computer Simulation; Cytochrome P-450 CYP2C8; Cytochrome P-450 CYP3A; Humans; Inactivation, Metabolic; Liver; Liver-Specific Organic Anion Transporter 1; Models, Biological; Pharmaceutical Preparations; Pharmacokinetics; Piperidines | 2019 |
Antidiabetic Drugs and Their Nanoconjugates Repurposed as Novel Antimicrobial Agents against Acanthamoeba
Topics: Acanthamoeba castellanii; Amebicides; Anti-Infective Agents; Carbamates; HeLa Cells; Humans; Hypoglycemic Agents; Metal Nanoparticles; Nanoconjugates; Piperidines; Silver; Sulfonylurea Compounds; Vildagliptin | 2019 |
The Structural Basis for the Binding of Repaglinide to the Pancreatic K
Topics: Adenosine Triphosphate; Amino Acid Motifs; Amino Acid Sequence; Animals; Binding Sites; Carbamates; HEK293 Cells; Humans; Mice; Models, Molecular; Pancreas; Piperidines; Potassium Channels, Inwardly Rectifying; Protein Binding; Protein Interaction Mapping; Protein Subunits; Sulfonylurea Receptors | 2019 |
Comparison of mortality and cardiovascular event risk associated with various insulin secretagogues: A nationwide real-world analysis.
Topics: Aged; Carbamates; Cardiovascular Diseases; Cohort Studies; Diabetes Mellitus, Type 2; Diabetic Angiopathies; Female; Follow-Up Studies; Gliclazide; Glipizide; Glyburide; Humans; Hypoglycemic Agents; Insulin; Insulin Secretion; Male; Middle Aged; Mortality; Piperidines; Secretagogues; Sulfonylurea Compounds; Taiwan | 2019 |
A Variation in the ABCC8 Gene Is Associated with Type 2 Diabetes Mellitus and Repaglinide Efficacy in Chinese Type 2 Diabetes Mellitus Patients.
Topics: Alleles; Asian People; Carbamates; Case-Control Studies; Diabetes Mellitus, Type 2; Female; Genotype; Humans; Hypoglycemic Agents; Male; Middle Aged; Piperidines; Polymerase Chain Reaction; Polymorphism, Genetic; Polymorphism, Restriction Fragment Length; Sulfonylurea Receptors | 2019 |
Improved oral bioavailability of repaglinide, a typical BCS Class II drug, with a chitosan-coated nanoemulsion.
Topics: Administration, Oral; Animals; Biological Availability; Carbamates; Chitosan; Drug Compounding; Drug Liberation; Emulsions; Gastrointestinal Absorption; Humans; Hypoglycemic Agents; Intracellular Fluid; Male; Nanocapsules; Piperidines; Poloxamer; Polysorbates; Rats, Sprague-Dawley; Solubility | 2020 |
Risk of Hypoglycemia and Concomitant Use of Repaglinide and Clopidogrel: A Population-Based Nested Case-Control Study.
Topics: Aged; Aspirin; Carbamates; Case-Control Studies; Clopidogrel; Drug Interactions; Female; Humans; Hypoglycemia; Hypoglycemic Agents; Male; Middle Aged; Nateglinide; Piperidines; Platelet Aggregation Inhibitors | 2019 |
Mechanism of pharmacochaperoning in a mammalian K
Topics: Animals; Binding Sites; Carbamates; Cell Line; Cricetinae; Cryoelectron Microscopy; Cysteine; Glyburide; Humans; KATP Channels; Mammals; Models, Molecular; Mutation; Pharmaceutical Preparations; Piperidines; Potassium Channels, Inwardly Rectifying; Protein Binding; Rats | 2019 |
Expanded Physiologically-Based Pharmacokinetic Model of Rifampicin for Predicting Interactions With Drugs and an Endogenous Biomarker via Complex Mechanisms Including Organic Anion Transporting Polypeptide 1B Induction.
Topics: Biomarkers; Carbamates; Computer Simulation; Coproporphyrins; Drug Interactions; Glyburide; Humans; Models, Biological; Organic Anion Transporters; Piperidines; Rifampin | 2019 |
Fast dissolving electrospun polymeric films of anti-diabetic drug repaglinide: formulation and evaluation.
Topics: Administration, Oral; Animals; Blood Glucose; Calorimetry, Differential Scanning; Carbamates; Drug Carriers; Drug Compounding; Drug Evaluation, Preclinical; Drug Liberation; Glucose Tolerance Test; Hydrophobic and Hydrophilic Interactions; Hypoglycemic Agents; Models, Animal; Nanofibers; Piperidines; Polyvinyl Alcohol; Povidone; Rats; Solubility; Surface Properties | 2019 |
Repaglinide-loaded nanostructured lipid carriers with different particle sizes for improving oral absorption: preparation, characterization, pharmacokinetics, and
Topics: Administration, Oral; Animals; Biological Availability; Carbamates; Drug Carriers; Drug Compounding; Intestinal Absorption; Intestinal Mucosa; Intestines; Nanostructures; Particle Size; Perfusion; Piperidines; Rats; Rats, Sprague-Dawley | 2020 |
Determination of Chemical Stability of Two Oral Antidiabetics, Metformin and Repaglinide in the Solid State and Solutions Using LC-UV, LC-MS, and FT-IR Methods.
Topics: Administration, Oral; Carbamates; Chromatography, Liquid; Drug Stability; Excipients; Hypoglycemic Agents; Kinetics; Mass Spectrometry; Metformin; Piperidines; Reproducibility of Results; Solutions; Spectroscopy, Fourier Transform Infrared; Ultraviolet Rays | 2019 |
Repaglinide Silences the FOXO3/Lumican Axis and Represses the Associated Metastatic Potential of Neuronal Cancer Cells.
Topics: Carbamates; Cell Line, Tumor; Cell Movement; Down-Regulation; Forkhead Box Protein O3; Gene Expression Regulation, Neoplastic; Gene Knockdown Techniques; Humans; Lumican; Neuroblastoma; Piperidines; Promoter Regions, Genetic; Protein Binding | 2019 |
Molecular pharmacokinetic mechanism of the drug-drug interaction between genistein and repaglinide mediated by P-gp.
Topics: Animals; Area Under Curve; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Caco-2 Cells; Carbamates; Dogs; Drug Interactions; Genistein; Humans; Intestinal Absorption; Madin Darby Canine Kidney Cells; Male; Molecular Docking Simulation; Piperidines; Rats; Rats, Wistar; Rhodamine 123 | 2020 |
Acarbose versus Repaglinide in Diabetes Treatment: A New Appraisal of Two Old Rivals.
Topics: Acarbose; Adult; Aged; Blood Glucose; Carbamates; Diabetes Mellitus, Type 2; Female; Humans; Hyperglycemia; Hypoglycemic Agents; Iran; Male; Middle Aged; Piperidines | 2020 |
Predicted values for human total clearance of a variety of typical compounds with differently humanized-liver mouse plasma data.
Topics: Acetamides; Albuterol; Animals; Carbamates; Chromatography, Liquid; Diazepam; Diclofenac; Digitoxin; Humans; Itraconazole; Ketoprofen; Liver; Metabolic Clearance Rate; Mice; Mice, Transgenic; Naproxen; Pharmaceutical Preparations; Phenytoin; Piperidines; Pravastatin; Pyrimidines; Quinidine; Tandem Mass Spectrometry; Telmisartan; Terfenadine; Verapamil | 2020 |
Spray dried solid dispersion of repaglinide using hypromellose acetate succinate:
Topics: Acetates; Animals; Carbamates; Chemistry, Pharmaceutical; Hypromellose Derivatives; Pharmaceutical Preparations; Piperidines; Rats; Solubility; Succinates | 2020 |
Repaglinide and Metformin-Loaded Amberlite Resin-Based Floating Microspheres for the Effective Management of Type 2 Diabetes.
Topics: Animals; Carbamates; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Metformin; Mice; Microspheres; Piperidines; Rats; Resins, Synthetic | 2021 |
The Impact of Surfactant Composition and Surface Charge of Niosomes on the Oral Absorption of Repaglinide as a BCS II Model Drug.
Topics: Administration, Oral; Animals; Biological Availability; Caco-2 Cells; Carbamates; Drug Delivery Systems; Drug Liberation; Hexoses; Humans; Liposomes; Male; Piperidines; Polysorbates; Rats, Wistar; Surface-Active Agents | 2020 |
Hypoglycemia during the Concomitant Use of Repaglinide and Clopidogrel in an Elderly Patient with Type 2 Diabetes and Severe Renal Insufficiency.
Topics: Aged; Blood Glucose; Carbamates; Clopidogrel; Diabetes Mellitus, Type 2; Humans; Hypoglycemia; Hypoglycemic Agents; Piperidines; Renal Insufficiency | 2021 |
Development of anti-acanthamoebic approaches.
Topics: Acanthamoeba castellanii; Acanthamoeba Keratitis; Acarbose; Antiprotozoal Agents; Carbamates; Cell Line; Contact Lens Solutions; Contact Lenses; HaCaT Cells; Humans; Indenes; Inositol; Nanoparticles; Piperidines; Sulfonylurea Compounds; Triazines; Vildagliptin | 2021 |
High-Performance affinity chromatographic studies of repaglinide and nateglinide interactions with normal and glyoxal- or methylglyoxal-modified human albumin serum.
Topics: Carbamates; Chromatography, Affinity; Glycosylation; Glyoxal; Humans; Nateglinide; Piperidines; Protein Binding; Pyruvaldehyde; Serum Albumin; Serum Albumin, Human | 2021 |
Improving the Translation of Organic Anion Transporting Polypeptide Substrates using HEK293 Cell Data in the Presence and Absence of Human Plasma via Physiologically Based Pharmacokinetic Modeling.
Topics: Administration, Intravenous; Carbamates; Drug Discovery; HEK293 Cells; Humans; Liver-Specific Organic Anion Transporter 1; Models, Biological; Piperidines; Plasma; Pravastatin; Quinolines; Rosuvastatin Calcium; Solute Carrier Organic Anion Transporter Family Member 1B3 | 2021 |
Risk of Death and Heart Failure among Patients with Type 2 Diabetes Treated by Metformin and Nonmetformin Monotherapy: A Real-World Study.
Topics: Aged; Benzamides; Carbamates; Cardiovascular Diseases; Cause of Death; Diabetes Mellitus, Type 2; Dipeptidyl-Peptidase IV Inhibitors; Female; Glycoside Hydrolase Inhibitors; Heart Failure; Hospitalization; Humans; Hypoglycemic Agents; Male; Metformin; Middle Aged; Mortality; Nateglinide; Piperidines; Proportional Hazards Models; Retrospective Studies; Sulfonylurea Compounds; Thiazolidinediones | 2021 |
Angiotensin-Converting Enzyme Inhibitors Used Concomitantly with Insulin Secretagogues and the Risk of Serious Hypoglycemia.
Topics: Administrative Claims, Healthcare; Aged; Aged, 80 and over; Angiotensin-Converting Enzyme Inhibitors; Carbamates; Databases, Factual; Diabetes Mellitus, Type 2; Drug Interactions; Female; Glipizide; Glyburide; Humans; Hypoglycemia; Hypoglycemic Agents; Insulin; Male; Medicaid; Metformin; Middle Aged; Nateglinide; Pharmacoepidemiology; Piperidines; Secretagogues; Sulfonylurea Compounds; United States | 2022 |
Meglitinide (repaglinide) therapy in permanent neonatal diabetes mellitus: two case reports.
Topics: Benzamides; Carbamates; Diabetes Mellitus; Humans; Hypoglycemic Agents; Iran; Mutation; Piperidines | 2021 |
Clinical Effects of Exercise Rehabilitation Combined with Repaglinide in the Treatment of Diabetes.
Topics: Carbamates; Diabetes Mellitus, Type 2; Humans; Hypoglycemic Agents; Piperidines; Retrospective Studies | 2022 |
Repaglinide-laden hydrogel particles of xanthan gum derivatives for the management of diabetes.
Topics: Blood Glucose; Carbamates; Diabetes Mellitus; Humans; Hydrogels; Piperidines; Polysaccharides, Bacterial | 2022 |
In vitro maturation medium supplementation: utilization of repaglinide, L-carnitine, and mesenchymal stem cell-conditioned medium to improve developmental competence of oocytes derived from endometriosis mouse models.
Topics: Animals; Antioxidants; Blastocyst; Carbamates; Carnitine; Culture Media, Conditioned; Dietary Supplements; Endometriosis; Female; Fertilization in Vitro; Humans; In Vitro Oocyte Maturation Techniques; Mesenchymal Stem Cells; Mice; Oocytes; Piperidines; Pregnancy | 2022 |
Antidiabetic and neuroprotective effects of a novel repaglinide analog.
Topics: Adenosine Triphosphate; Animals; Antioxidants; Benzoic Acid; Biomarkers; Blood Glucose; Carbamates; Diabetes Mellitus, Experimental; Eosine Yellowish-(YS); Glucokinase; Glucose Transport Proteins, Facilitative; Glutamate Dehydrogenase; Hematoxylin; Hypoglycemic Agents; Insulin; KATP Channels; Molecular Docking Simulation; Neuroprotective Agents; Oxidative Stress; Piperidines; Potassium; Rats; Reactive Oxygen Species; RNA, Messenger; Secretagogues | 2022 |