carbamates and l 685458

carbamates has been researched along with l 685458 in 81 studies

Research

Studies (81)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	52 (64.20)	29.6817
2010's	28 (34.57)	24.3611
2020's	1 (1.23)	2.80

Authors

Authors	Studies
DiMuzio-Mower, J; Gardell, SJ; Huang, Q; Lai, MT; Li, YM; Sardana, MK; Shafer, JA; Shi, XP; Xu, M; Yin, KC	1
Beher, D; Castro, JL; Clarke, EE; Harrison, T; Hunt, P; Lewis, HD; Nadin, A; Shearman, MS; Smith, AL; Stevenson, G	1
Berechid, B; Bingham, SJ; Chu, S; Kim, SH; Martys-Zage, JL; Nye, J; Sisodia, SS; Sklar, J	1
Haass, C; Prywes, R; Shearman, MS; Steiner, H; Winkler, E	1
Carpenter, G; Golde, TE; Murphy, MP; Ni, CY	1
Austin, CP; Chen, E; Figueroa, DJ; Kandpal, G; Li, YM; Ma, L; Morris, JA	1
Birr, C; Edwards, PD; Greenberg, BD; Liu, X; Scott, CD; Sobotka-Briner, CD; Sylvester, MA; Tian, G; Zysk, J	1
Capell, A; Edbauer, D; Haass, C; Kaether, C; Lammich, S; Okochi, M; Steiner, H; Takeda, M; Walter, J; Zimmer, AK	1
Ihara, Y; Mitsumori, R; Morishima-Kawashima, M; Qi, Y; Sato, T	1
De Strooper, B; Iwatsubo, T; Kawano, Y; Murakami, D; Nagano, O; Okamoto, I; Saya, H; Tomita, T; Yumoto, E	1
Aharony, D; Ghanekar, SV; Greenberg, BD; Jacobs, RT; Liu, X; Shenvi, AB; Tian, G	1
Harrison, T; Lewis, HD; Nadin, A; Neduvelil, JG; Pérez Revuelta, BI; Pollack, SJ; Shearman, MS	1
Blokzijl, A; Chapman, G; Dahlqvist, C; Dannaeus, K; Falk, A; Ibâñez, CF; Lendahl, U	1
Alves Da Costa, C; Andrau, D; Ayral, E; Checler, F; Dumanchin-Njock, C; Farzan, M; Fulcrand, P; Hernandez, JF; Marambaud, P; Martinez, J; Pasini, A; Petit, A; Phiel, CJ; Wilk, S	1
Abdulkadir, SA; McDonald, JM; Zayzafoon, M	1
Li, YM	1
Baki, L; Gama-Sosa, M; Neve, R; Robakis, NK; Schwarzman, A; Shao, Z; Shioi, J; Wen, P	1
Miyajima, A; Tanimizu, N	1
Komano, H; Kurono, Y; Maeda, Y; Nishimura, M; Sai, X; Shiraishi, H; Wang, HQ; Yanagisawa, K	1
Chun, J; Li, YM; Tarassishin, L; Yang, G; Yin, YI	1
Frank, M; Haas, IG; Kemler, R; Véron, N	1
Barnes, NY; Parent, AT; Sisodia, SS; Taniguchi, Y; Thinakaran, G	1
Canterford, LD; Culvenor, JG; Evin, G; Hoke, DE; Masters, CL; Sharples, RA	1
Aoto, J; Conn, E; Holderfield, M; Hughes, CC; Koller, E; Nakatsu, MN; Sainson, RC	1
DelleDonne, A; Humphrey, J; Mullan, M; Paris, D; Patel, N; Quadros, A	1
Chung, IY; Kang, JH; Kim, HJ; Lee, DH; Lee, JS; Lee, YH; Lee, YS; Park, CS; Shin, JW	1
Cui, MZ; Dong, Y; Mao, G; Sun, L; Tan, J; Xu, X; Zhao, G	1
Harris, AL; Li, JL; Murga, M; Tosato, G; Williams, CK	1
Dash, PK; Moore, AN; Orsi, SA	1
Cejudo-Martin, P; Johnson, RS	1
Bondesson, M; Gradin, K; Gustafsson, MV; Jin, S; Lendahl, U; Lundkvist, J; Pereira, T; Poellinger, L; Ruas, JL; Zheng, X	1
Bernstein, A; Crouthamel, MC; DiMuzio, J; Donoviel, DB; Gardell, SJ; Hazuda, D; Lai, MT; Li, YM; Pietrak, BL	1
Fukuyama, T; Fuwa, H; Iwatsubo, T; Kan, T; Morohashi, Y; Natsugari, H; Okamura, Y; Sato, C; Tominari, Y; Tomita, T; Watanabe, N	1
Battina, SK; Hong, HS; Hua, DH; Iwamoto, T; Jin, LW; Maezawa, I; Martin, GM; Pettersson, E; Radke, GA; Rana, S; Wu, HC	1
Cui, MZ; Mao, G; Tan, J; Xu, X; Zhao, G	1
Clough, RW; Li, YM; Luo, XG; Struble, RG; Xiong, K; Yan, XX	1
Efthimiopoulos, S; Fassa, A; Parisiadou, L; Robakis, NK	1
Hayashi, H; Kaneda, Y; Koriyama, H; Mori, M; Morishita, R; Nakagami, H; Nishikawa, T; Saito, Y; Sato, N; Takami, Y; Tamai, K	1
Duan, L; Fan, M; Wu, X; Yao, J	1
Ihara, Y; Ishiura, S; Morishima-Kawashima, M; Yagishita, S	1
Basi, G; Hu, K; Jagodzinski, J; Lee, M; Marugg, J; Neitzel, M; Schenk, D; Yednock, T; Yu, M; Zhao, B	1
Barnham, KJ; Hill, AF; Masters, CL; Naylor, R; Nisbet, RM; Perez, K; Sharples, RA; Vella, LJ	1
Bekaert, S; Cools, J; De Keersmaecker, K; Folens, C; Lahortiga, I; Marynen, P; Mentens, N; Odero, MD; Van Neste, L; Vandenberghe, P	1
Crosby, G; Culley, DJ; Dong, Y; Moir, RD; Tanzi, RE; Tian, M; Xia, W; Xie, Z; Yue, Y; Zhang, B; Zhang, G	1
An, J; Polavarapu, R; Yepes, M; Zhang, C	1
Grogan, SP; Hiraoka, K; Lotz, MK; Olee, T	1
Mayo, KE; Trombly, DJ; Woodruff, TK	1
Bahamontes-Rosa, N; Chen, H; Chishti, AH; Crompton, PD; Kun, JF; Li, X; Traore, B	1
Corallini, F; di Iasio, MG; Gattei, V; Melloni, E; Rimondi, E; Secchiero, P; Tiribelli, M; Zauli, G	1
Beraud, E; Lombardo, D; Mathieu, S; Ristorcelli, E; Verine, A	1
Allalunis-Turner, J; Han, J; Hendzel, MJ; Ma, I	1
Dong, Y; Li, S; Lu, Y; Norton, D; Tian, M; Wu, X; Xie, Z; Xu, Z; Zhang, Y; Zhen, Y	1
Ma, L; Pei, G; Teng, L; Wang, F; Zhao, J	1
Aburatani, H; Enomoto, S; Hamakubo, T; Ito, H; Kawamura, T; Kodama, T; Seki, M; Watanabe, A	1
Ankarcrona, M; Behbahani, H; Frykman, S; Pavlov, PF; Sakai, J; Wiehager, B; Winblad, B	1
Buck, CB; Huang, HS; Lambert, PF	1
Gaiano, N; Hong, JS; Kim, ST; Koh, YH; Kweon, DH; Kwon, ST; Lee, KY; Park, KW; Yang, MS; Yoon, K	1
Gadadhar, A; Lazarov, O; Marr, R	1
Amanda, WZ; Butler-Browne, G; Gluckman, PD; Hui, GZ; Kambadur, R; Lau, HY; Lokireddy, S; McFarlane, C; Mouly, V; Sharma, M; Xiaojia, G	1
Blusztajn, JK; Carey, RM; Slack, BE	1
Ansaloni, S; Chakraborty, R; Delvadia, R; Desai, A; Goldstein, LE; Khandelwal, P; Lee, JC; Marenda, DR; Melicharek, DJ; Mhatre, SD; Michelson, SJ; Miller, S; Moir, RD; Paddock, BE; Saunders, AJ; Tabb, LP; Utreja, S; Vepuri, V; Vinokur, M	1
Belyea, BC; Bentley, RC; Linardic, CM; Naini, S	1
Borgegard, T; Eriksson, H; Johansson, J; Juréus, A; Klintenberg, R; Li, T; Lundkvist, J; Malinowsky, D; Nord, J; Olsson, F; Parpal, S; Paulsen, K; Radesater, AC; Regner, A; Rosqvist, S; Rotticci, D; Sabirsh, A; Singh, R; Stromberg, K; Waldman, M; Yan, H	1
Araki, W; Asakura, K; Cazzaniga, E; Hirabayashi, Y; Ito, S; Kawamura, N; Masserini, M; Miyashita, T; Muto, E; Mutoh, T; Shima, S	1
Dou, F; Lv, D; Miao, F; Shen, Y; Wang, J; Yin, Y; Zhang, J	1
Andreyeva, A; Gottmann, K; Horstmann, K; Klapper, S; Korth, C; Müller-Schiffmann, A; Nieweg, K	1
Bellio, N; Cagnin, M; Fiorentino, I; Follo, C; Isidoro, C; Ozzano, M	1
Abematsu, M; Ishidou, Y; Kawabata, N; Kitamoto, S; Komiya, S; Maeda, S; Nagano, S; Nagao, H; Setoguchi, T; Yokouchi, M; Yonezawa, S	1
Ahn, JH; Boo, JH; Jeon, GS; Kang, DE; Kim, C; Kim, KH; Kim, YE; Mook-Jung, I; Ryu, H; Song, H	1
Fiala, C; Haider, S; Knöfler, M; Meinhardt, G; Otti, GR; Pollheimer, J; Velicky, P; Whitley, G	1
Chen, CL; Cheng, SF; De Felici, M; Feng, YM; Li, L; Liang, GJ; Pan, B; Qin, XS; Shen, W; Zhang, XF	1
Allen, SJ; Ghiasi, H; Mott, KR	1
Cai, Y; Huang, H; Li, JM; Luo, XG; Mou, L; Xiao, L; Yan, XX; Yang, ZY	1
Frykman, S; Inoue, M; Ishikawa, T; Kihara, T; Schedin-Weiss, S; Teranishi, Y; Tjernberg, LO; Wiehager, B; Winblad, B; Yamamoto, NG	1
Barth, TF; Beltinger, C; Berthold, F; Debatin, KM; Dorneburg, C; Fischer, M; Goß, AV; Kappler, R; Molenaar, JJ; Oswald, F; Roels, F; Siveke, JT	1
Althani, A; Casalbore, P; Cenciarelli, C; Felsani, A; Giannetti, S; Mangiola, A; Marei, HE; Trevisi, G; Zonfrillo, M	1
Deng, Y; Du, X; Hai, Y; Li, H; Li, N; Li, W; Wei, L; Yin, W; Zeng, R; Zhang, L; Zhang, Z; Zheng, B	1
Chiu, YW; Fukumori, A; Ihara, Y; Ikeuchi, T; Kodama, TS; Kudo, T; Matsuura, Y; Mizuta, N; Nishitomi, K; Okamoto, T; Okochi, M; Oyama, H; Sakaguchi, G; Tagami, S; Takami, M; Takeda, M; Yanagida, K	1
Hitzenberger, M; Zacharias, M	1
Ma, W; Wang, L; Zeng, X; Zeng, Z; Zhang, H; Zhang, W; Zheng, R	1
Li, H; Sui, S; Wang, L; Xu, S; Zhang, L; Zhang, X; Zheng, X	1

Reviews

3 review(s) available for carbamates and l 685458

Article	Year
Gamma-secretase: a catalyst of Alzheimer disease and signal transduction. Molecular interventions, 2001, Volume: 1, Issue:4 Topics: Alzheimer Disease; Amyloid beta-Protein Precursor; Amyloid Precursor Protein Secretases; Animals; Aspartic Acid Endopeptidases; Binding Sites; Carbamates; Catalysis; Dipeptides; Endopeptidases; Enzyme Inhibitors; Humans; Membrane Proteins; Models, Biological; Molecular Structure; Plaque, Amyloid; Receptors, Notch; Signal Transduction; Substrate Specificity	2001
A new notch in the HIF belt: how hypoxia impacts differentiation. Developmental cell, 2005, Volume: 9, Issue:5 Topics: Animals; Carbamates; Cell Differentiation; Dipeptides; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Myoblasts; Receptors, Notch; Stem Cells	2005
Proton myo-inositol cotransporter is a novel γ-secretase associated protein that regulates Aβ production without affecting Notch cleavage. The FEBS journal, 2015, Volume: 282, Issue:17 Topics: Adenosine Triphosphatases; Amyloid beta-Peptides; Amyloid Precursor Protein Secretases; Animals; Brain Chemistry; Brain-Derived Neurotrophic Factor; Carbamates; Dipeptides; Enzyme Inhibitors; Gene Expression Regulation; Gene Knockdown Techniques; Glucose Transport Proteins, Facilitative; Hippocampus; Humans; Inositol; Mice; Microsomes; Molecular Sequence Annotation; Neurons; Peptide Fragments; Phospholipid Transfer Proteins; Primary Cell Culture; Protein Binding; Protein Stability; Proteolysis; Protons; Receptors, Notch; RNA, Small Interfering; Signal Transduction	2015

Other Studies

78 other study(ies) available for carbamates and l 685458

Article	Year
Presenilin 1 is linked with gamma-secretase activity in the detergent solubilized state. Proceedings of the National Academy of Sciences of the United States of America, 2000, May-23, Volume: 97, Issue:11 Topics: Alzheimer Disease; Amyloid beta-Protein Precursor; Amyloid Precursor Protein Secretases; Aspartic Acid Endopeptidases; Carbamates; Cell Fractionation; Cell Membrane; Cholic Acids; Detergents; Dipeptides; Endopeptidases; HeLa Cells; Humans; Membrane Proteins; Neoplasm Proteins; Pepstatins; Presenilin-1; Protease Inhibitors; Recombinant Fusion Proteins; Solubility; Substrate Specificity	2000
L-685,458, an aspartyl protease transition state mimic, is a potent inhibitor of amyloid beta-protein precursor gamma-secretase activity. Biochemistry, 2000, Aug-01, Volume: 39, Issue:30 Topics: Amino Acid Sequence; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Amyloid Precursor Protein Secretases; Animals; Aspartic Acid Endopeptidases; Carbamates; Cell Line; CHO Cells; Cricetinae; Dipeptides; Endopeptidases; Humans; Molecular Conformation; Molecular Mimicry; Molecular Sequence Data; Protease Inhibitors; Stereoisomerism; Structure-Activity Relationship; Substrate Specificity	2000
Requirement for presenilin 1 in facilitating lagged 2-mediated endoproteolysis and signaling of notch 1. Journal of molecular neuroscience : MN, 2000, Volume: 15, Issue:3 Topics: Alzheimer Disease; Amyloid beta-Protein Precursor; Amyloid Precursor Protein Secretases; Animals; Aspartic Acid Endopeptidases; Carbamates; Carrier Proteins; Cell Line, Transformed; Cell Membrane; Cell Nucleus; Dipeptides; Endopeptidases; Fetus; Fibroblasts; Green Fluorescent Proteins; Indicators and Reagents; Intercellular Signaling Peptides and Proteins; Jagged-2 Protein; Luminescent Proteins; Membrane Proteins; Mice; Mice, Knockout; Peptide Fragments; Peptide Hydrolases; Presenilin-1; Protease Inhibitors; Receptor, Notch1; Receptors, Cell Surface; Recombinant Fusion Proteins; Signal Transduction; Transcription Factors; Translocation, Genetic	2000
Endoproteolysis of the ER stress transducer ATF6 in the presence of functionally inactive presenilins. Neurobiology of disease, 2001, Volume: 8, Issue:4 Topics: Activating Transcription Factor 6; Amyloid beta-Protein Precursor; Amyloid Precursor Protein Secretases; Aspartic Acid Endopeptidases; Carbamates; Cell Line; Dipeptides; DNA-Binding Proteins; Endopeptidases; Humans; Kidney; Membrane Proteins; Mutagenesis; Plaque, Amyloid; Presenilin-1; Presenilin-2; Protease Inhibitors; Receptors, Notch; Transcription Factors; Transfection	2001
gamma -Secretase cleavage and nuclear localization of ErbB-4 receptor tyrosine kinase. Science (New York, N.Y.), 2001, Dec-07, Volume: 294, Issue:5549 Topics: Active Transport, Cell Nucleus; Amino Acid Sequence; Amyloid Precursor Protein Secretases; Animals; Aspartic Acid Endopeptidases; Carbamates; Cell Division; Cell Line; Cell Membrane; Cell Nucleus; COS Cells; Cytoplasm; Dipeptides; Endopeptidases; ErbB Receptors; Fatty Acids, Unsaturated; Humans; Membrane Proteins; Metalloendopeptidases; Mice; Molecular Sequence Data; Mutation; Neuregulin-1; Presenilin-1; Protease Inhibitors; Protein Structure, Tertiary; Receptor, ErbB-4; Recombinant Fusion Proteins; Signal Transduction; Tetradecanoylphorbol Acetate; Transcriptional Activation; Tumor Cells, Cultured	2001
Presenilin-dependent gamma-secretase activity modulates neurite outgrowth. Neurobiology of disease, 2002, Volume: 9, Issue:1 Topics: Adaptor Proteins, Signal Transducing; Adult; Alzheimer Disease; Amyloid Precursor Protein Secretases; Animals; Aspartic Acid Endopeptidases; Calcium-Calmodulin-Dependent Protein Kinases; Carbamates; Dipeptides; Dishevelled Proteins; Endopeptidases; Endoplasmic Reticulum; Glycogen Synthase Kinase 3; Golgi Apparatus; Hippocampus; Humans; Macaca mulatta; Membrane Proteins; Neurites; Neuroblastoma; Phosphoproteins; Presenilin-1; Protease Inhibitors; Receptor, Notch1; Receptors, Cell Surface; Transcription Factors; Tumor Cells, Cultured	2002
Linear non-competitive inhibition of solubilized human gamma-secretase by pepstatin A methylester, L685458, sulfonamides, and benzodiazepines. The Journal of biological chemistry, 2002, Aug-30, Volume: 277, Issue:35 Topics: Amyloid Precursor Protein Secretases; Aspartic Acid Endopeptidases; Benzodiazepines; Binding Sites; Carbamates; Dipeptides; Endopeptidases; Humans; Kinetics; Models, Molecular; Pepstatins; Protease Inhibitors; Recombinant Proteins; Sulfonamides	2002
Presenilin-dependent intramembrane proteolysis of CD44 leads to the liberation of its intracellular domain and the secretion of an Abeta-like peptide. The Journal of biological chemistry, 2002, Nov-22, Volume: 277, Issue:47 Topics: Alzheimer Disease; Amino Acid Sequence; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Amyloid Precursor Protein Secretases; Animals; Aspartic Acid Endopeptidases; Carbamates; Cell Line; Cell Membrane; Dipeptides; Endopeptidases; Enzyme Inhibitors; Fibroblasts; gamma-Aminobutyric Acid; Humans; Hyaluronan Receptors; Membrane Proteins; Mice; Mice, Knockout; Molecular Sequence Data; Peptides; Presenilin-1; Presenilin-2; Protein Structure, Tertiary; Sequence Alignment; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Triglycerides	2002
Distinct mechanisms by mutant presenilin 1 and 2 leading to increased intracellular levels of amyloid beta-protein 42 in Chinese hamster ovary cells. Biochemistry, 2003, Feb-04, Volume: 42, Issue:4 Topics: Amino Acid Substitution; Amyloid beta-Peptides; Amyloid Precursor Protein Secretases; Animals; Asparagine; Aspartic Acid; Aspartic Acid Endopeptidases; Carbamates; Cell Line; Cell-Free System; CHO Cells; Cricetinae; Culture Media; Dipeptides; Endopeptidases; Humans; Intracellular Fluid; Isoleucine; Membrane Proteins; Methionine; Mutagenesis, Site-Directed; Peptide Fragments; Presenilin-1; Presenilin-2; Serine Proteinase Inhibitors; Threonine; Transfection; Up-Regulation; Valine	2003
Presenilin-dependent gamma-secretase activity mediates the intramembranous cleavage of CD44. Oncogene, 2003, Mar-13, Volume: 22, Issue:10 Topics: Amyloid Precursor Protein Secretases; Animals; Aspartic Acid Endopeptidases; Carbamates; Cell Membrane; Central Nervous System Neoplasms; Dipeptides; Embryo, Mammalian; Endopeptidases; Fibroblasts; Glioma; Humans; Hyaluronan Receptors; Leupeptins; Membrane Proteins; Mice; Mice, Knockout; Pepstatins; Presenilin-1; Protease Inhibitors; Signal Transduction; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured	2003
The mechanism of gamma-secretase: multiple inhibitor binding sites for transition state analogs and small molecule inhibitors. The Journal of biological chemistry, 2003, Aug-01, Volume: 278, Issue:31 Topics: Amyloid Precursor Protein Secretases; Aspartic Acid Endopeptidases; Benzodiazepines; Binding Sites; Binding, Competitive; Carbamates; Catalysis; Dipeptides; Endopeptidases; Enzyme Inhibitors; Humans; Kinetics; Mathematics; Pepstatins; Solubility; Sulfonamides; Tritium	2003
Catalytic site-directed gamma-secretase complex inhibitors do not discriminate pharmacologically between Notch S3 and beta-APP cleavages. Biochemistry, 2003, Jun-24, Volume: 42, Issue:24 Topics: Alzheimer Disease; Amyloid beta-Protein Precursor; Amyloid Precursor Protein Secretases; Aspartic Acid Endopeptidases; Blotting, Western; Carbamates; Catalytic Domain; Cell Line; Dipeptides; Dose-Response Relationship, Drug; Endopeptidases; Humans; Inhibitory Concentration 50; Membrane Proteins; Molecular Mimicry; Protease Inhibitors; Protein Structure, Tertiary; Receptors, Notch; Signal Transduction	2003
Functional Notch signaling is required for BMP4-induced inhibition of myogenic differentiation. Development (Cambridge, England), 2003, Volume: 130, Issue:24 Topics: Animals; Basic Helix-Loop-Helix Transcription Factors; Bone Morphogenetic Protein 4; Bone Morphogenetic Proteins; Carbamates; Cell Differentiation; Cell Line; Dipeptides; DNA-Binding Proteins; Gene Expression Regulation; Genes, Reporter; Humans; Membrane Proteins; Mice; Muscles; Promoter Regions, Genetic; Receptors, Notch; Recombinant Fusion Proteins; Repressor Proteins; Signal Transduction; Smad Proteins; Smad1 Protein; Stem Cells; Trans-Activators	2003
JLK isocoumarin inhibitors: selective gamma-secretase inhibitors that do not interfere with notch pathway in vitro or in vivo. Journal of neuroscience research, 2003, Nov-01, Volume: 74, Issue:3 Topics: Amyloid beta-Peptides; Amyloid Precursor Protein Secretases; Animals; Anticoagulants; Aspartic Acid Endopeptidases; Blotting, Western; Cadherins; Carbamates; Cell Line; Cysteine Endopeptidases; Dipeptides; Dose-Response Relationship, Drug; Embryo, Mammalian; Embryo, Nonmammalian; Endopeptidases; gamma-Aminobutyric Acid; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Humans; In Situ Hybridization; In Vitro Techniques; Kidney; Membrane Proteins; Multienzyme Complexes; Mutation; Peptide Fragments; Precipitin Tests; Proteasome Endopeptidase Complex; Receptors, Notch; Time Factors; Transfection; Triglycerides; Zebrafish	2003
Notch signaling and ERK activation are important for the osteomimetic properties of prostate cancer bone metastatic cell lines. The Journal of biological chemistry, 2004, Jan-30, Volume: 279, Issue:5 Topics: Basic Helix-Loop-Helix Transcription Factors; Blotting, Western; Bone Neoplasms; Calcium; Carbamates; Cell Differentiation; Cell Line, Tumor; Cell Nucleus; Core Binding Factor Alpha 1 Subunit; Dipeptides; DNA; Enzyme Activation; Homeodomain Proteins; Humans; Immunohistochemistry; Intracellular Signaling Peptides and Proteins; Male; Membrane Proteins; Mitogen-Activated Protein Kinases; Models, Biological; Neoplasm Metastasis; Neoplasm Proteins; Osteoblasts; Prostatic Neoplasms; Protein Binding; Receptors, Notch; Reverse Transcriptase Polymerase Chain Reaction; RNA; RNA, Ribosomal, 18S; Signal Transduction; Time Factors; Transcription Factor HES-1; Transcription Factors	2004
PS1 activates PI3K thus inhibiting GSK-3 activity and tau overphosphorylation: effects of FAD mutations. The EMBO journal, 2004, Jul-07, Volume: 23, Issue:13 Topics: Alzheimer Disease; Animals; Apoptosis; Blotting, Western; Cadherins; Carbamates; Cell Line, Transformed; Cell Survival; Cell Transformation, Viral; Dipeptides; Enzyme Activation; Enzyme Inhibitors; Fibroblasts; Flow Cytometry; Glycogen Synthase Kinase 3; Humans; Membrane Proteins; Mice; Mice, Knockout; Mutation; Phosphatidylinositol 3-Kinases; Phosphorylation; Precipitin Tests; Presenilin-1; Protein Serine-Threonine Kinases; Protein Structure, Tertiary; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Simplexvirus; tau Proteins	2004
Notch signaling controls hepatoblast differentiation by altering the expression of liver-enriched transcription factors. Journal of cell science, 2004, Jul-01, Volume: 117, Issue:Pt 15 Topics: Animals; Biocompatible Materials; Blotting, Northern; Calcium-Binding Proteins; Carbamates; CCAAT-Enhancer-Binding Protein-alpha; Cell Differentiation; Cell Lineage; Collagen; Dipeptides; DNA-Binding Proteins; Drug Combinations; Green Fluorescent Proteins; Hepatocyte Nuclear Factor 1-beta; Hepatocytes; Immunohistochemistry; Integrin beta4; Intercellular Signaling Peptides and Proteins; Jagged-1 Protein; Keratin-7; Keratins; Laminin; Ligands; Liver; MAP Kinase Kinase Kinases; Membrane Proteins; Mice; Mice, Inbred C57BL; Plasmids; Protein Serine-Threonine Kinases; Protein Structure, Tertiary; Proteins; Proteoglycans; Receptor, Notch2; Receptors, Cell Surface; Receptors, Notch; Retroviridae; Reverse Transcriptase Polymerase Chain Reaction; RNA; RNA, Small Interfering; Serrate-Jagged Proteins; Signal Transduction; Transcription Factors; Transcription, Genetic; Up-Regulation	2004
PEN-2 enhances gamma-cleavage after presenilin heterodimer formation. Journal of neurochemistry, 2004, Volume: 90, Issue:6 Topics: Alanine; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Amyloid Precursor Protein Secretases; Animals; Aspartic Acid; Aspartic Acid Endopeptidases; Blotting, Western; Carbamates; Cell Line; Dipeptides; Dose-Response Relationship, Drug; Endopeptidases; Enzyme Inhibitors; Enzyme-Linked Immunosorbent Assay; Fibroblasts; gamma-Aminobutyric Acid; Gene Expression Regulation; Membrane Glycoproteins; Membrane Proteins; Mice; Peptide Fragments; Presenilin-1; Presenilin-2; Protein Processing, Post-Translational; Proto-Oncogene Proteins c-myc; Radioimmunoassay; Statistics, Nonparametric; Transgenes; Triglycerides	2004
Stereoselective synthesis of photoreactive peptidomimetic gamma-secretase inhibitors. The Journal of organic chemistry, 2004, Oct-15, Volume: 69, Issue:21 Topics: Alzheimer Disease; Amyloid Precursor Protein Secretases; Aspartic Acid Endopeptidases; Carbamates; Cell Membrane; Dipeptides; Endopeptidases; Enzyme Inhibitors; Humans; Molecular Conformation; Molecular Mimicry; Peptide Fragments; Photochemistry; Stereoisomerism	2004
Presenilin-dependent processing and nuclear function of gamma-protocadherins. The Journal of biological chemistry, 2005, Mar-11, Volume: 280, Issue:10 Topics: Amyloid Precursor Protein Secretases; Animals; Aspartic Acid Endopeptidases; Cadherin Related Proteins; Cadherins; Carbamates; Cell Line; Chlorocebus aethiops; COS Cells; Dipeptides; Endopeptidases; Fibroblasts; Humans; Kidney; Matrix Metalloproteinases; Membrane Proteins; Mice; Presenilin-1; Presenilin-2; Protease Inhibitors; Protein Processing, Post-Translational; Recombinant Proteins; Transfection	2005
Presenilin attenuates receptor-mediated signaling and synaptic function. The Journal of neuroscience : the official journal of the Society for Neuroscience, 2005, Feb-09, Volume: 25, Issue:6 Topics: Amyloid Precursor Protein Secretases; Animals; Aspartic Acid Endopeptidases; Carbamates; Carbazoles; Cell Adhesion Molecules; Cell Line, Tumor; Cell Membrane; Colforsin; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; DCC Receptor; Dipeptides; Endopeptidases; Excitatory Postsynaptic Potentials; Genes, DCC; Glutamic Acid; Indoles; Lidocaine; Membrane Proteins; Memory; Mice; Mice, Inbred C57BL; Mice, Knockout; Neurites; Neuroblastoma; Neurons; Piperazines; Presenilin-1; Protein Processing, Post-Translational; Pyrroles; Quinoxalines; Rats; Receptors, Cell Surface; Recombinant Fusion Proteins; Second Messenger Systems; Synaptic Transmission; Transfection; Tumor Suppressor Proteins	2005
Transition-state analogue gamma-secretase inhibitors stabilize a 900 kDa presenilin/nicastrin complex. Biochemistry, 2005, Mar-22, Volume: 44, Issue:11 Topics: Amyloid Precursor Protein Secretases; Aspartic Acid Endopeptidases; Binding Sites; Carbamates; Cell Line, Tumor; Chromatography, Gel; Cross-Linking Reagents; Detergents; Dipeptides; Electrophoresis, Polyacrylamide Gel; Endopeptidases; Enzyme Stability; Humans; Membrane Glycoproteins; Membrane Proteins; Molecular Weight; Multiprotein Complexes; Peptide Fragments; Photochemistry; Presenilin-1; Protease Inhibitors; Protein Binding; Solubility; Subcellular Fractions	2005
Cell-autonomous notch signaling regulates endothelial cell branching and proliferation during vascular tubulogenesis. FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2005, Volume: 19, Issue:8 Topics: Amyloid Precursor Protein Secretases; Aspartic Acid Endopeptidases; Blood Vessels; Calcium-Binding Proteins; Capillaries; Carbamates; Cell Division; Cells, Cultured; Dipeptides; Endopeptidases; Endothelial Cells; Epidermal Growth Factor; Fluorescent Dyes; Humans; Intercellular Signaling Peptides and Proteins; Membrane Proteins; Neovascularization, Physiologic; Oligonucleotides, Antisense; Receptor, Notch1; Receptors, Notch; Reverse Transcriptase Polymerase Chain Reaction; Serrate-Jagged Proteins; Signal Transduction; Transfection; Umbilical Veins	2005
Inhibition of angiogenesis and tumor growth by beta and gamma-secretase inhibitors. European journal of pharmacology, 2005, May-02, Volume: 514, Issue:1 Topics: Amyloid Precursor Protein Secretases; Analysis of Variance; Animals; Aspartic Acid Endopeptidases; Brain; Capillaries; Carbamates; Cell Differentiation; Cell Line, Tumor; Cell Proliferation; Cells, Cultured; Dipeptides; Dose-Response Relationship, Drug; Endopeptidases; Endothelial Cells; Female; Humans; Mice; Mice, Nude; Morphogenesis; Neoplasms, Experimental; Neovascularization, Pathologic; Oligopeptides; Protease Inhibitors; Xenograft Model Antitumor Assays	2005
Eosinophilic differentiation is promoted by blockage of Notch signaling with a gamma-secretase inhibitor. European journal of immunology, 2005, Volume: 35, Issue:10 Topics: Amyloid Precursor Protein Secretases; Aspartic Acid Endopeptidases; Basic Helix-Loop-Helix Transcription Factors; Carbamates; Cell Death; Cell Differentiation; Cell Proliferation; Chemotaxis, Leukocyte; Dipeptides; Endopeptidases; Enzyme Inhibitors; Eosinophil Major Basic Protein; Eosinophils; Flow Cytometry; Homeodomain Proteins; Humans; Immunohistochemistry; Receptors, CCR3; Receptors, Chemokine; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Transcription Factor HES-1	2005
gamma-Cleavage is dependent on zeta-cleavage during the proteolytic processing of amyloid precursor protein within its transmembrane domain. The Journal of biological chemistry, 2005, Nov-11, Volume: 280, Issue:45 Topics: Amyloid beta-Protein Precursor; Amyloid Precursor Protein Secretases; Animals; Carbamates; Cell Line; Cell Membrane; Cell-Free System; Dipeptides; Endopeptidases; Enzyme Inhibitors; Protein Processing, Post-Translational; Protein Structure, Tertiary	2005
Up-regulation of the Notch ligand Delta-like 4 inhibits VEGF-induced endothelial cell function. Blood, 2006, Feb-01, Volume: 107, Issue:3 Topics: Adaptor Proteins, Signal Transducing; Amyloid Precursor Protein Secretases; Aspartic Acid Endopeptidases; Basic Helix-Loop-Helix Transcription Factors; Blood Proteins; Calcium-Binding Proteins; Carbamates; Cells, Cultured; Dipeptides; Endopeptidases; Endothelial Cells; Enzyme Inhibitors; Humans; Intercellular Signaling Peptides and Proteins; Ligands; Neovascularization, Physiologic; Protein Binding; Proto-Oncogene Proteins; Receptor, Notch1; Receptor, Notch4; Receptors, Notch; Repressor Proteins; Transfection; Umbilical Veins; Up-Regulation; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factor Receptor-2	2006
Blockade of gamma-secretase activity within the hippocampus enhances long-term memory. Biochemical and biophysical research communications, 2005, Dec-16, Volume: 338, Issue:2 Topics: Amyloid Precursor Protein Secretases; Animals; Carbamates; Conditioning, Classical; Dipeptides; Endopeptidases; Enzyme Activation; Hippocampus; Male; Maze Learning; Memory; Rats; Rats, Long-Evans	2005
Hypoxia requires notch signaling to maintain the undifferentiated cell state. Developmental cell, 2005, Volume: 9, Issue:5 Topics: Animals; Basic Helix-Loop-Helix Transcription Factors; Carbamates; Cell Differentiation; Cell Line; Cell Line, Tumor; Dipeptides; Homeodomain Proteins; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Mice; Myoblasts; Receptor, Notch1; Receptors, Notch; Repressor Proteins; Signal Transduction; Stem Cells; Transcription Factor HES-1	2005
A presenilin-independent aspartyl protease prefers the gamma-42 site cleavage. Journal of neurochemistry, 2006, Volume: 96, Issue:1 Topics: Amyloid beta-Peptides; Amyloid Precursor Protein Secretases; Animals; Aspartic Acid Endopeptidases; Blastocyst; Carbamates; Cell Membrane; Cells, Cultured; Dipeptides; DNA; Endopeptidases; Hydrogen-Ion Concentration; Luminescent Measurements; Membrane Proteins; Mice; Neurons; Presenilin-1; Presenilin-2; Transfection	2006
C-terminal fragment of presenilin is the molecular target of a dipeptidic gamma-secretase-specific inhibitor DAPT (N-[N-(3,5-difluorophenacetyl)-L-alanyl]-S-phenylglycine t-butyl ester). The Journal of biological chemistry, 2006, May-26, Volume: 281, Issue:21 Topics: Amyloid Precursor Protein Secretases; Aspartic Acid Endopeptidases; Binding Sites; Carbamates; Chromatography; Dipeptides; Endopeptidases; gamma-Aminobutyric Acid; HeLa Cells; Humans; Inhibitory Concentration 50; Membrane Proteins; Models, Chemical; Peptides; Presenilin-1; Protein Structure, Tertiary; Receptors, Notch; Triglycerides	2006
A novel tricyclic pyrone compound ameliorates cell death associated with intracellular amyloid-beta oligomeric complexes. Journal of neurochemistry, 2006, Volume: 98, Issue:1 Topics: Amyloid beta-Peptides; Carbamates; Cell Count; Cell Death; Cell Line, Tumor; Dipeptides; Dose-Response Relationship, Drug; Drug Interactions; Enzyme-Linked Immunosorbent Assay; Fluorescent Antibody Technique; Humans; Intracellular Space; Microscopy, Atomic Force; Neuroblastoma; Neuroprotective Agents; Pyrones; Surface Plasmon Resonance; Time Factors	2006
The same gamma-secretase accounts for the multiple intramembrane cleavages of APP. Journal of neurochemistry, 2007, Volume: 100, Issue:5 Topics: Amyloid beta-Peptides; Amyloid Precursor Protein Secretases; Animals; Anti-Inflammatory Agents, Non-Steroidal; Carbamates; Cell Line, Tumor; Cell Membrane; Dipeptides; Humans; Ibuprofen; Mice; Peptide Fragments; Sulindac	2007
[3H]-L-685,458 as a radiotracer that maps gamma-secretase complex in the rat brain: relevance to Abeta genesis and presence of active presenilin-1 components. Brain research, 2007, Jul-09, Volume: 1157 Topics: Amyloid beta-Peptides; Amyloid Precursor Protein Secretases; Animals; Animals, Newborn; Binding Sites; Binding, Competitive; Brain; Brain Mapping; Carbamates; Cells, Cultured; Dipeptides; Enzyme Inhibitors; Female; Male; Mossy Fibers, Hippocampal; Olfactory Bulb; Organ Culture Techniques; Peptide Fragments; Presenilin-1; Radioligand Assay; Rats; Rats, Sprague-Dawley; Tritium	2007
Novel processing of Notch 1 within its intracellular domain by a cysteine protease. Neuro-degenerative diseases, 2007, Volume: 4, Issue:2-3 Topics: Carbamates; Cell Line, Transformed; Cysteine Endopeptidases; Cytoplasm; Dipeptides; Enzyme Inhibitors; Gene Expression Regulation; Humans; Immunoprecipitation; Mutation; Protein Structure, Tertiary; Protein Transport; Receptor, Notch1; Transfection	2007
Involvement of gamma-secretase in postnatal angiogenesis. Biochemical and biophysical research communications, 2007, Nov-23, Volume: 363, Issue:3 Topics: Amyloid Precursor Protein Secretases; Animals; Blood Vessels; Blotting, Western; Carbamates; Cattle; Cell Movement; Cell Proliferation; Cells, Cultured; Dipeptides; Endothelial Cells; Epidermal Growth Factor; Fibroblast Growth Factor 2; Gene Expression; Humans; Immunohistochemistry; Muscle, Smooth, Vascular; Neovascularization, Physiologic; Platelet Endothelial Cell Adhesion Molecule-1; Promoter Regions, Genetic; Proto-Oncogene Proteins c-fos; Reverse Transcriptase Polymerase Chain Reaction; Substrate Specificity; Vascular Endothelial Growth Factor A	2007
Gamma-secretase inhibitors exerts antitumor activity via down-regulation of Notch and Nuclear factor kappa B in human tongue carcinoma cells. Oral diseases, 2007, Volume: 13, Issue:6 Topics: Amyloid Precursor Protein Secretases; Analysis of Variance; Apoptosis; Carbamates; Cell Cycle; Dipeptides; Down-Regulation; Drug Screening Assays, Antitumor; Enzyme Inhibitors; Humans; NF-kappa B; Proto-Oncogene Mas; Receptors, Notch; Tongue Neoplasms; Tumor Cells, Cultured	2007
Abeta46 is processed to Abeta40 and Abeta43, but not to Abeta42, in the low density membrane domains. The Journal of biological chemistry, 2008, Jan-11, Volume: 283, Issue:2 Topics: Amyloid beta-Peptides; Amyloid Precursor Protein Secretases; Animals; Carbamates; Cell Membrane; CHO Cells; Cricetinae; Cricetulus; Dipeptides; Enzyme Inhibitors; Kinetics; Peptide Fragments	2008
Identification of gamma-secretase inhibitor potency determinants on presenilin. The Journal of biological chemistry, 2008, Feb-01, Volume: 283, Issue:5 Topics: Alzheimer Disease; Amino Acid Sequence; Amyloid beta-Peptides; Amyloid Precursor Protein Secretases; Animals; Carbamates; Dipeptides; Enzyme Inhibitors; Humans; Mice; Mice, Knockout; Molecular Sequence Data; Presenilin-1; Presenilin-2; Sequence Homology, Amino Acid; Sulfonamides	2008
Inhibition of gamma-secretase causes increased secretion of amyloid precursor protein C-terminal fragments in association with exosomes. FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2008, Volume: 22, Issue:5 Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Amyloid Precursor Protein Secretases; Animals; Carbamates; Cattle; CHO Cells; Cricetinae; Cricetulus; Culture Media, Conditioned; Cytoplasmic Vesicles; Dipeptides	2008
In vitro validation of gamma-secretase inhibitors alone or in combination with other anti-cancer drugs for the treatment of T-cell acute lymphoblastic leukemia. Haematologica, 2008, Volume: 93, Issue:4 Topics: Amyloid Precursor Protein Secretases; Antineoplastic Agents; Apoptosis; Benzamides; Benzodiazepinones; Carbamates; Cell Cycle; Cell Division; Cell Line, Tumor; Daunorubicin; Dexamethasone; Dipeptides; DNA, Neoplasm; Drug Screening Assays, Antitumor; Drug Synergism; Enzyme Inhibitors; Humans; Imatinib Mesylate; In Vitro Techniques; Leukemia-Lymphoma, Adult T-Cell; Mutation; Neoplasm Proteins; Oncogene Proteins, Fusion; Piperazines; Pyrimidines; Receptor, Notch1; Sequence Analysis, DNA; Vincristine	2008
The inhalation anesthetic desflurane induces caspase activation and increases amyloid beta-protein levels under hypoxic conditions. The Journal of biological chemistry, 2008, May-02, Volume: 283, Issue:18 Topics: Amyloid beta-Peptides; Amyloid Precursor Protein Secretases; Anesthetics, Inhalation; Aspartic Acid Endopeptidases; Carbamates; Caspase 3; Caspase Inhibitors; Cell Hypoxia; Cell Line, Tumor; Clioquinol; Desflurane; Dipeptides; Enzyme Activation; Humans; Isoflurane; Models, Biological; Oligopeptides; Protein Processing, Post-Translational; Protein Structure, Quaternary	2008
Regulated intramembrane proteolysis of the low-density lipoprotein receptor-related protein mediates ischemic cell death. The American journal of pathology, 2008, Volume: 172, Issue:5 Topics: Active Transport, Cell Nucleus; Amyloid Precursor Protein Secretases; Animals; Brain; Brain Ischemia; Carbamates; Caspase 3; Cell Death; Cell Membrane; Cell Nucleus; Cells, Cultured; Cerebral Infarction; Dipeptides; Fibroblasts; Infarction, Middle Cerebral Artery; Low Density Lipoprotein Receptor-Related Protein-1; Mice; Mice, Inbred C57BL; Mice, Mutant Strains; Neurons; Signal Transduction	2008
Repression of chondrogenesis through binding of notch signaling proteins HES-1 and HEY-1 to N-box domains in the COL2A1 enhancer site. Arthritis and rheumatism, 2008, Volume: 58, Issue:9 Topics: Basic Helix-Loop-Helix Transcription Factors; Blotting, Western; Bone Morphogenetic Protein 6; Carbamates; Cell Cycle Proteins; Cell Differentiation; Cells, Cultured; Chondrogenesis; Chromatin Immunoprecipitation; Collagen Type II; Dipeptides; Fibroblast Growth Factor 2; Homeodomain Proteins; Humans; Mesenchymal Stem Cells; Receptors, Notch; Regulatory Sequences, Nucleic Acid; Repressor Proteins; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction; Time Factors; Transcription Factor HES-1; Transforming Growth Factor beta3	2008
Suppression of Notch signaling in the neonatal mouse ovary decreases primordial follicle formation. Endocrinology, 2009, Volume: 150, Issue:2 Topics: Amyloid Precursor Protein Secretases; Animals; Animals, Newborn; Carbamates; Cell Differentiation; Cells, Cultured; Dipeptides; Down-Regulation; Enzyme Inhibitors; Female; gamma-Aminobutyric Acid; Germ Cells; Mice; Ovarian Follicle; Ovary; Receptors, Notch; Signal Transduction; Triglycerides	2009
Plasmodium falciparum signal peptide peptidase is a promising drug target against blood stage malaria. Biochemical and biophysical research communications, 2009, Mar-13, Volume: 380, Issue:3 Topics: Amino Acid Sequence; Animals; Antimalarials; Aspartic Acid Endopeptidases; Carbamates; Dipeptides; Drug Design; Erythrocytes; Humans; Malaria, Falciparum; Molecular Sequence Data; Plasmodium falciparum; Protease Inhibitors; Protein Conformation; RNA, Small Interfering	2009
Nutlin-3 up-regulates the expression of Notch1 in both myeloid and lymphoid leukemic cells, as part of a negative feedback antiapoptotic mechanism. Blood, 2009, Apr-30, Volume: 113, Issue:18 Topics: Adult; Aged; Aged, 80 and over; Amyloid Precursor Protein Secretases; Apoptosis; Blotting, Western; Carbamates; Cell Differentiation; Dipeptides; Drug Synergism; Drug Therapy, Combination; Feedback, Physiological; Female; HL-60 Cells; Humans; Imidazoles; Leukemia, Lymphocytic, Chronic, B-Cell; Male; Middle Aged; Osteoclasts; Piperazines; Receptor, Notch1; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Stereoisomerism; Tumor Suppressor Protein p53; Up-Regulation	2009
Essential role of Notch signaling in apoptosis of human pancreatic tumoral cells mediated by exosomal nanoparticles. International journal of cancer, 2009, Sep-01, Volume: 125, Issue:5 Topics: Adenocarcinoma; Amyloid Precursor Protein Secretases; Apoptosis; Basic Helix-Loop-Helix Transcription Factors; Blotting, Western; Carbamates; Caspase 3; Cell Differentiation; Cell Proliferation; Dipeptides; Exosomes; Flow Cytometry; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Homeodomain Proteins; Humans; Mitochondria; Nanoparticles; Pancreatic Neoplasms; PTEN Phosphohydrolase; Receptors, Notch; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Transcription Factor HES-1; Tumor Cells, Cultured	2009
The cytotoxicity of gamma-secretase inhibitor I to breast cancer cells is mediated by proteasome inhibition, not by gamma-secretase inhibition. Breast cancer research : BCR, 2009, Volume: 11, Issue:4 Topics: Adenocarcinoma; Amyloid Precursor Protein Secretases; Breast Neoplasms; Carbamates; Cell Line, Tumor; Dipeptides; Drug Delivery Systems; Estrogens; Female; Humans; Neoplasm Proteins; Neoplasms, Hormone-Dependent; Oligopeptides; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Receptor, Notch1; Receptors, Estrogen	2009
Nitrous oxide plus isoflurane induces apoptosis and increases beta-amyloid protein levels. Anesthesiology, 2009, Volume: 111, Issue:4 Topics: Actins; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Amyloid Precursor Protein Secretases; Anesthetics, Inhalation; Animals; Apoptosis; Blotting, Western; Carbamates; Caspase 3; Cell Line, Tumor; Dipeptides; Enzyme Activation; Enzyme Inhibitors; Enzyme-Linked Immunosorbent Assay; Humans; In Situ Nick-End Labeling; Isoflurane; Mice; Neurons; Nitrous Oxide	2009
A GPCR/secretase complex regulates beta- and gamma-secretase specificity for Abeta production and contributes to AD pathogenesis. Cell research, 2010, Volume: 20, Issue:2 Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid Precursor Protein Secretases; Animals; Aspartic Acid Endopeptidases; Carbamates; Cells, Cultured; Dipeptides; Enkephalin, Leucine-2-Alanine; Humans; Mice; Mice, Inbred C57BL; Mice, Transgenic; Multiprotein Complexes; Naltrexone; Narcotic Antagonists; Protein Transport; Receptors, G-Protein-Coupled; Receptors, Opioid, delta; Substrate Specificity; Transport Vesicles	2010
Human ROBO1 is cleaved by metalloproteinases and gamma-secretase and migrates to the nucleus in cancer cells. FEBS letters, 2010, Jul-02, Volume: 584, Issue:13 Topics: Amino Acid Sequence; Amyloid Precursor Protein Secretases; Carbamates; Cell Nucleus; Dipeptides; Hep G2 Cells; Humans; Hydroxamic Acids; Immunoblotting; Immunohistochemistry; Leupeptins; Metalloproteases; Molecular Sequence Data; Nerve Tissue Proteins; Receptors, Immunologic; Roundabout Proteins; Sequence Homology, Amino Acid; Tandem Mass Spectrometry	2010
Mitochondrial γ-secretase participates in the metabolism of mitochondria-associated amyloid precursor protein. FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2011, Volume: 25, Issue:1 Topics: Amyloid beta-Protein Precursor; Amyloid Precursor Protein Secretases; Animals; Blotting, Western; Carbamates; Cell Line, Tumor; Cells, Cultured; Dipeptides; Embryo, Mammalian; Embryonic Stem Cells; Fibroblasts; Humans; Mice; Mice, Inbred C57BL; Mice, Knockout; Microscopy, Confocal; Mitochondria; Mitochondrial Membranes; Mitochondrial Proteins; Presenilin-1; Presenilin-2; Substrate Specificity	2011
Inhibition of gamma secretase blocks HPV infection. Virology, 2010, Nov-25, Volume: 407, Issue:2 Topics: Amyloid Precursor Protein Secretases; Animals; Anti-Infective Agents; Carbamates; Cell Line; Cells, Cultured; Dipeptides; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Genital Diseases, Female; Human papillomavirus 16; Humans; Keratinocytes; Mice; Papillomavirus Infections; Treatment Outcome	2010
Among γ-secretase substrates Notch1 alone is sufficient to block neurogenesis but does not confer self-renewal properties to neural stem cells. Biochemical and biophysical research communications, 2011, Jan-07, Volume: 404, Issue:1 Topics: Amyloid Precursor Protein Secretases; Animals; Astrocytes; Carbamates; Dipeptides; Female; Mice; Mice, Inbred Strains; Neural Stem Cells; Neurogenesis; Protein Structure, Tertiary; Receptor, Notch1; Transcriptional Activation	2011
Presenilin-1 regulates neural progenitor cell differentiation in the adult brain. The Journal of neuroscience : the official journal of the Society for Neuroscience, 2011, Feb-16, Volume: 31, Issue:7 Topics: Adult Stem Cells; Analysis of Variance; Animals; Bromodeoxyuridine; Carbamates; Cell Count; Cell Differentiation; Cells, Cultured; Cerebral Ventricles; Dipeptides; Down-Regulation; Enzyme Inhibitors; Green Fluorescent Proteins; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Neurogenesis; Neurons; Presenilin-1; RNA, Small Interfering; Transfection	2011
Human myostatin negatively regulates human myoblast growth and differentiation. American journal of physiology. Cell physiology, 2011, Volume: 301, Issue:1 Topics: Adolescent; Animals; Basic Helix-Loop-Helix Transcription Factors; Carbamates; Cell Cycle; Cell Cycle Proteins; Cell Differentiation; Cell Proliferation; Cells, Cultured; Child; Dipeptides; DNA-Binding Proteins; Homeodomain Proteins; Humans; Immunoprecipitation; Mice; Muscle Development; Muscle Fibers, Skeletal; Muscle, Skeletal; Myoblasts; MyoD Protein; Myogenic Regulatory Factors; Myostatin; p21-Activated Kinases; Polymerase Chain Reaction; Receptors, Notch; Recombinant Proteins; Repressor Proteins; Signal Transduction; Smad Proteins; Transcription Factor HES-1; Transforming Growth Factor beta	2011
Surface expression and limited proteolysis of ADAM10 are increased by a dominant negative inhibitor of dynamin. BMC cell biology, 2011, May-17, Volume: 12 Topics: ADAM Proteins; ADAM10 Protein; Amyloid beta-Protein Precursor; Amyloid Precursor Protein Secretases; Carbachol; Carbamates; Cell Line; Dipeptides; Dynamin I; Endocytosis; Humans; Membrane Proteins; Protein Kinase C; Receptor, Muscarinic M3	2011
Characterization of a Drosophila Alzheimer's disease model: pharmacological rescue of cognitive defects. PloS one, 2011, Volume: 6, Issue:6 Topics: Alzheimer Disease; Amyloid beta-Protein Precursor; Amyloid Precursor Protein Secretases; Animals; Behavior, Animal; Brain; Carbamates; Cognition; Dipeptides; Disease Models, Animal; Drosophila melanogaster; Drug Evaluation, Preclinical; Female; Gene Expression Regulation, Enzymologic; Humans; Male; Motor Activity; Phenotype; Protease Inhibitors; Reflex; Time Factors	2011
Inhibition of the Notch-Hey1 axis blocks embryonal rhabdomyosarcoma tumorigenesis. Clinical cancer research : an official journal of the American Association for Cancer Research, 2011, Dec-01, Volume: 17, Issue:23 Topics: Amyloid Precursor Protein Secretases; Animals; Basic Helix-Loop-Helix Transcription Factors; Carbamates; Cell Cycle Proteins; Cell Differentiation; Cell Line, Tumor; Cell Proliferation; Cell Transformation, Neoplastic; Dipeptides; Humans; Mice; Mice, SCID; Muscle Development; Muscles; Receptors, Notch; Rhabdomyosarcoma, Embryonal; RNA Interference; RNA, Small Interfering; Signal Transduction; Xenograft Model Antitumor Assays	2011
First and second generation γ-secretase modulators (GSMs) modulate amyloid-β (Aβ) peptide production through different mechanisms. The Journal of biological chemistry, 2012, Apr-06, Volume: 287, Issue:15 Topics: Alanine; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Amyloid Precursor Protein Secretases; Animals; Azepines; Binding, Competitive; Brain; Carbamates; Cell-Free System; Dibenzazepines; Dipeptides; Drug Interactions; Female; Flurbiprofen; Guinea Pigs; HEK293 Cells; Humans; Imidazoles; Mice; Mice, Inbred C57BL; Piperidines; Protein Binding; Protein Processing, Post-Translational; Pyrans; Pyridines; Pyrimidines; Rats; Receptor, EphA4; Receptor, EphB2; Receptors, Notch; Sulfonamides; Sulindac	2012
Abnormal cross-talk between mutant presenilin 1 (I143T, G384A) and glycosphingolipid biosynthesis. FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2012, Volume: 26, Issue:7 Topics: Alzheimer Disease; Amino Acid Substitution; Amyloid Precursor Protein Secretases; Animals; Base Sequence; Brain; Carbamates; Cell Line; Dipeptides; DNA Primers; Enzyme Inhibitors; Glucosyltransferases; Glycosphingolipids; Humans; Mice; Mice, Transgenic; Mutant Proteins; Mutation; Presenilin-1; Recombinant Proteins; RNA, Messenger; Transfection	2012
GSI-I has a better effect in inhibiting hepatocellular carcinoma cell growth than GSI-IX, GSI-X, or GSI-XXI. Anti-cancer drugs, 2012, Volume: 23, Issue:7 Topics: Amyloid Precursor Protein Secretases; Antineoplastic Agents; Basic Helix-Loop-Helix Transcription Factors; Benzodiazepinones; Calcium-Binding Proteins; Carbamates; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Proliferation; Cell Survival; Dipeptides; Gene Expression Regulation, Neoplastic; Genes, myc; Hep G2 Cells; Homeodomain Proteins; Humans; Intercellular Signaling Peptides and Proteins; Jagged-1 Protein; Liver Neoplasms; Membrane Proteins; Oligopeptides; Receptors, Notch; Serrate-Jagged Proteins; Transcription Factor HES-1	2012
C-terminal fragment of N-cadherin accelerates synapse destabilization by amyloid-β. Brain : a journal of neurology, 2012, Volume: 135, Issue:Pt 7 Topics: Aged; Aged, 80 and over; Alzheimer Disease; Amyloid beta-Peptides; Amyloid Precursor Protein Secretases; Animals; Antigens, CD; Cadherins; Carbamates; Cells, Cultured; Dipeptides; Female; Gene Expression; Humans; Mice; Mice, Inbred C57BL; Miniature Postsynaptic Potentials; Neurons; Peptide Fragments; Presenilin-1; Protein Processing, Post-Translational; Proteolysis; Synapses	2012
Dopamine induces apoptosis in APPswe-expressing Neuro2A cells following Pepstatin-sensitive proteolysis of APP in acid compartments. Brain research, 2012, Aug-30, Volume: 1471 Topics: Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Amyloid Precursor Protein Secretases; Animals; Apoptosis; bcl-2-Associated X Protein; Carbamates; Cathepsin D; Cell Line, Tumor; Chloroquine; Dipeptides; Dopamine; Dose-Response Relationship, Drug; Endocytosis; Gene Expression Regulation, Neoplastic; Green Fluorescent Proteins; Humans; In Situ Nick-End Labeling; Lysosomes; Mice; Mitochondrial Membranes; Neuroblastoma; Pepstatins; Phorbol Esters; Protease Inhibitors; Protein Biosynthesis; Proteolysis; RNA, Small Interfering; Transfection	2012
RBPJ is a novel target for rhabdomyosarcoma therapy. PloS one, 2012, Volume: 7, Issue:7 Topics: Animals; Carbamates; Cell Line, Tumor; Cell Proliferation; Dibenzazepines; Dipeptides; Gene Expression Regulation, Neoplastic; Gene Knockdown Techniques; Humans; Immunoglobulin J Recombination Signal Sequence-Binding Protein; Mice; Mice, Nude; Receptors, Notch; Rhabdomyosarcoma; RNA Interference; Signal Transduction; Tumor Burden; Xenograft Model Antitumor Assays	2012
Critical role of presenilin-dependent γ-secretase activity in DNA damage-induced promyelocytic leukemia protein expression and apoptosis. Cell death and differentiation, 2013, Volume: 20, Issue:4 Topics: Alzheimer Disease; Amyloid Precursor Protein Secretases; Animals; Apoptosis; Brain; Camptothecin; Carbamates; Cell Line; Dipeptides; DNA Damage; Gene Expression; Gene Knockout Techniques; HEK293 Cells; Humans; Leukemia, Promyelocytic, Acute; Mice; Nuclear Proteins; Presenilins; Promyelocytic Leukemia Protein; RNA Interference; RNA, Messenger; RNA, Small Interfering; Signal Transduction; Transcription Factors; Tumor Suppressor Protein p53; Tumor Suppressor Proteins; Up-Regulation	2013
Notch signaling plays a critical role in motility and differentiation of human first-trimester cytotrophoblasts. Endocrinology, 2014, Volume: 155, Issue:1 Topics: Apoptosis; Carbamates; Cell Differentiation; Cell Movement; Cell Proliferation; Cells, Cultured; Chorionic Villi; Dipeptides; Female; Gene Expression Profiling; Humans; Ligands; Microscopy, Fluorescence; Pregnancy; Pregnancy Trimester, First; Receptors, Notch; RNA, Small Interfering; Signal Transduction; Trophoblasts	2014
Notch pathway regulates female germ cell meiosis progression and early oogenesis events in fetal mouse. Cell cycle (Georgetown, Tex.), 2014, Volume: 13, Issue:5 Topics: Adaptor Proteins, Signal Transducing; Animals; Apoptosis; Carbamates; Dipeptides; Female; Fetus; Meiosis; Methylation; Mice; Oocytes; Oogenesis; Promoter Regions, Genetic; Receptor, Notch1; Signal Transduction; Tretinoin	2014
Inhibitors of signal peptide peptidase (SPP) affect HSV-1 infectivity in vitro and in vivo. Experimental eye research, 2014, Volume: 123 Topics: Animals; Aspartic Acid Endopeptidases; Aspirin; Carbamates; Cell Fractionation; Cells, Cultured; Dipeptides; Disease Models, Animal; DNA, Viral; Enzyme Inhibitors; Female; Gene Expression Regulation, Viral; Herpesvirus 1, Human; Ibuprofen; Keratitis, Herpetic; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Ophthalmic Solutions; Rabbits; Real-Time Polymerase Chain Reaction; RNA, Messenger; Skin; Virus Replication	2014
[(3) H]-L685,458 binding sites are abundant in multiple peripheral organs in rats: implications for safety assessment of putative γ-secretase targeting drugs. Basic & clinical pharmacology & toxicology, 2014, Volume: 115, Issue:6 Topics: Amyloid Precursor Protein Secretases; Animals; Binding Sites; Brain; Carbamates; Dipeptides; Female; Hair; Heart; Jejunum; Kidney; Liver; Male; Pituitary Gland; Rats; Skin; Testis; Tissue Distribution	2014
γ-Secretase inhibitor I inhibits neuroblastoma cells, with NOTCH and the proteasome among its targets. Oncotarget, 2016, 09-27, Volume: 7, Issue:39 Topics: Amyloid Precursor Protein Secretases; Animals; Apoptosis; Brain Neoplasms; Carbamates; Cell Cycle; Cell Line, Tumor; Dipeptides; Enzyme Inhibitors; Female; Humans; In Situ Hybridization, Fluorescence; Mice; Mitosis; N-Myc Proto-Oncogene Protein; Neoplasm Transplantation; Neovascularization, Pathologic; Neuroblastoma; Oligopeptides; Proteasome Endopeptidase Complex; Receptor, Notch1; Receptors, Notch; Signal Transduction	2016
The interference of Notch1 target Hes1 affects cell growth, differentiation and invasiveness of glioblastoma stem cells through modulation of multiple oncogenic targets. Oncotarget, 2017, Mar-14, Volume: 8, Issue:11 Topics: Apoptosis; Benzimidazoles; Brain Neoplasms; Carbamates; Cell Differentiation; Cell Proliferation; Dipeptides; ErbB Receptors; Glioblastoma; Humans; Microtubule-Associated Proteins; Neoplasm Invasiveness; Neoplastic Stem Cells; Phosphorylation; Piperidines; Receptor, Notch1; RNA Interference; RNA, Small Interfering; Signal Transduction; STAT3 Transcription Factor; STAT5 Transcription Factor; Transcription Factor HES-1; Tumor Suppressor Proteins	2017
CpG in Combination with an Inhibitor of Notch Signaling Suppresses Formalin-Inactivated Respiratory Syncytial Virus-Enhanced Airway Hyperresponsiveness and Inflammation by Inhibiting Th17 Memory Responses and Promoting Tissue-Resident Memory Cells in Lung Journal of virology, 2017, 05-15, Volume: 91, Issue:10 Topics: Adjuvants, Immunologic; Animals; Bronchial Hyperreactivity; Carbamates; CD8-Positive T-Lymphocytes; Dipeptides; Formaldehyde; Humans; Immunologic Memory; Inflammation; Lung; Mice; Mice, Inbred BALB C; Oligodeoxyribonucleotides; Receptors, Notch; Respiratory Syncytial Virus Infections; Respiratory Syncytial Virus Vaccines; Respiratory Syncytial Virus, Human; Signal Transduction; Th17 Cells; Toll-Like Receptor 1; Vaccines, Inactivated	2017
Semagacestat Is a Pseudo-Inhibitor of γ-Secretase. Cell reports, 2017, Oct-03, Volume: 21, Issue:1 Topics: Alanine; Alzheimer Disease; Amyloid beta-Protein Precursor; Amyloid Precursor Protein Secretases; Animals; Azepines; Carbamates; Cell Differentiation; Clinical Trials as Topic; Dipeptides; Disease Models, Animal; Drug Administration Schedule; Enzyme Inhibitors; Gene Expression Regulation; HEK293 Cells; Humans; Induced Pluripotent Stem Cells; Mice; Neurons	2017
Uncovering the Binding Mode of γ -Secretase Inhibitors. ACS chemical neuroscience, 2019, 08-21, Volume: 10, Issue:8 Topics: Amyloid Precursor Protein Secretases; Carbamates; Dipeptides; Drug Design; Enzyme Inhibitors; Molecular Docking Simulation; Protein Binding; Substrate Specificity	2019
Inhibiting the Notch signaling pathway suppresses Th17-associated airway hyperresponsiveness in obese asthmatic mice. Laboratory investigation; a journal of technical methods and pathology, 2019, Volume: 99, Issue:12 Topics: Amyloid Precursor Protein Secretases; Animals; Asthma; Carbamates; Dipeptides; Disease Models, Animal; Drug Evaluation, Preclinical; Lung; Male; Mice, Inbred C57BL; Obesity; Random Allocation; Receptors, Notch; Signal Transduction; Th17 Cells	2019
Inhibition of tumor propellant glutathione peroxidase 4 induces ferroptosis in cancer cells and enhances anticancer effect of cisplatin. Journal of cellular physiology, 2020, Volume: 235, Issue:4 Topics: A549 Cells; Animals; Carbamates; Cell Movement; Cisplatin; Dipeptides; DNA Methylation; Epigenesis, Genetic; Ferroptosis; Heterografts; Histones; Humans; Lapatinib; Mice; Neoplasm Invasiveness; Neoplasms; Phospholipid Hydroperoxide Glutathione Peroxidase; Piperazines; Pyridines; Topotecan	2020