Compounds > carbamates

carbamates and glyceryl 2-arachidonate

carbamates has been researched along with glyceryl 2-arachidonate in 66 studies

Research

Studies (66)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's18 (27.27)29.6817
2010's45 (68.18)24.3611
2020's3 (4.55)2.80

Authors

AuthorsStudies
Darmani, NA; Di Marzo, V; McClanahan, BA; Petrosino, S; Trinh, C; Valenti, M1
Fegley, D; Gutierrez, T; Hohmann, AG; Piomelli, D; Suplita, RL1
Ho, WS; Randall, MD1
Laitinen, JT; Lehtonen, M; Palomäki, VA; Savinainen, JR1
Drysdale, AJ; Pertwee, RG; Platt, B; Ryan, D1
Kaiser, N; Lutz, B; Monory, K; Moreira, FA1
Artmann, A; Clausen, BH; Degn, M; Finsen, B; Hansen, HS; Hansen, SH; Lambertsen, KL; Lund, TM; Meldgaard, M; Petersen, G1
Gauthier, KM; Hammock, BD; Hillard, CJ; Ho, WS; Huang, H; Thompson, J; Wheelock, CE1
Béquet, F; Desbazeille, M; Le Fur, G; Ludwiczak, P; Maftouh, M; Picard, C; Scatton, B; Uzabiaga, F1
Blankman, JL; Cravatt, BF; Simon, GM1
Fowler, CJ; Ghafouri, N1
Avraham, HK; Avraham, S; Koziel, H; Lu, TS; Makriyannis, A; Seng, S; Tachado, SD1
Kovacs, FE; Szabo, B; Urbanski, MJ1
Abdullah, RA; Boger, DL; Cravatt, BF; Kinsey, SG; Lichtman, AH; Long, JZ; O'Neal, ST; Poklis, JL1
Cravatt, BF; Hillard, CJ; Liu, QS; Long, JZ; Pan, B; Sun, D; Wang, W1
Fowler, CJ; Thors, L1
Anagnostopoulos, D; Gkini, E; Mavri-Vavayianni, M; Siafaka-Kapadai, A1
Booker, L; Burston, JJ; Cravatt, BF; Jin, X; Lichtman, AH; Long, JZ; Nomura, DK; Sim-Selley, LJ; Vann, RE; Walentiny, DM; Wiley, JL1
Bernardi, G; Cantarella, C; Castelli, M; Cavasinni, F; Centonze, D; De Chiara, V; Mataluni, G; Musella, A; Rossi, S1
Alger, BE; Kim, J1
Anagnostopoulos, D; Evagorou, A; Farmaki, E; Siafaka-Kapadai, A1
Busquets-Garcia, A; de la Torre, R; Maldonado, R; Ozaita, A; Pastor, A; Puighermanal, E1
Baldeyroux, B; Hamtiaux, L; Lambert, DM; Lansiaux, A; Matuszak, N; Muccioli, GG; Poupaert, JH1
Astarita, G; Caprioli, G; Ciccocioppo, R; Cippitelli, A; Duranti, A; Kallupi, M; Piomelli, D; Rodrìguez de Fonseca, F; Sagratini, G; Stopponi, S; Ubaldi, M1
Bambico, FR; Gobbi, G; Gorzalka, BB; Hill, MN; Hillard, CJ; McLaughlin, RJ; Stuhr, KL1
Buczynski, MW; Chang, JW; Cognetta, AB; Cravatt, BF; Lum, KM; Matthews, ML; Niessen, S; Niphakis, MJ; Parsons, LH; Wang, C1
Bowie, AG; Campbell, VA; Gowran, A; Keating, SE; Noonan, J; Tanveer, R1
Barker, E; Chester, JA; Cooper, BR; Davisson, VJ; Han, B; Kirchhoff, AM; Wright, R1
Przewlocka, B; Starowicz, K1
Bradshaw, HB; Guindon, J; Hohmann, AG; Lai, Y; Takacs, SM1
Tchantchou, F; Zhang, Y1
Cristino, L; De Petrocellis, L; Di Marzo, V; Korostynski, M; Makuch, W; Malek, N; Petrosino, S; Przewlocka, B; Slezak, M; Starowicz, K; Zychowska, M1
Abdullah, RA; Imhof, E; Lichtman, AH; Limebeer, CL; Parker, LA; Rock, EM; Wang, K1
Alhouayek, M; Cani, PD; Lambert, DM; Masquelier, J; Muccioli, GG1
Basavarajappa, BS; Nagre, NN; Subbanna, S; Xie, S1
Bystrowska, B; Filip, M; Gawliński, D; Pomierny, B; Smaga, I; Stankowicz, P1
Chavant, F; Duranti, A; Francheteau, M; Gennequin, B; Maccarrone, M; Makriyannis, A; Nader, J; Rapino, C; Solinas, M; Thiriet, N1
Bader, M; Brosnihan, KB; Dechend, R; Howlett, AC; McGee, CM; Pulgar, VM; Varagic, J; Yamaleyeva, LM1
Drew, GM; Lau, BK; Mitchell, VA; Vaughan, CW1
Impastato, RA; Katz, PS; Molina, PE; Rogers, EK; Sulzer, JK; Teng, SX1
Atsak, P; Campolongo, P; Cuomo, V; Hauer, D; McGaugh, JL; Morena, M; Peloso, A; Ratano, P; Roozendaal, B; Schelling, G; Trabace, L; Trezza, V1
Arlt, H; Augé, F; Avenet, P; Beeské, S; Bergis, OE; Bert, L; Bertrand, T; Brittain, S; Didier, M; Escoubet, J; Even, L; Françon, D; George, P; Griebel, G; He, T; Houtmann, J; Jacquet, A; Leroy, T; Lopez-Grancha, M; Menet, V; Michot, N; Mikol, V; Pichat, P; Rak, A; Redon, N; Sun, F; Tolstykh, T; Vallée, F; Wiederschain, D; Yu, Q; Zhang, B1
Belluomo, I; Chaouloff, F; Marsicano, G; Matias, I; Pernègre, C1
Vann, RE; Walentiny, DM; Wiley, JL1
Campolongo, P; Cuomo, V; Hill, MN; Manduca, A; Morena, M; Palmery, M; Servadio, M; Trabace, L; Trezza, V; Vanderschuren, LJ1
Hinz, B; Ivanov, I; Peters, K; Ramer, R; Salamon, A; Wollank, Y1
Campolongo, P; De Castro, V; Gray, JM; Hill, MN; Morena, M; Palmery, M; Roozendaal, B; Trezza, V1
Abdullah, RA; Cravatt, BF; Ho, W; Lichtman, AH; Limebeer, CL; Niphakis, MJ; Parker, LA; Poklis, JL; Rafla, BR; Sharkey, KA; Sticht, MA1
Cravatt, BF; Limebeer, CL; Millett, G; Niphakis, MJ; Parker, LA; Petrie, GN; Rock, EM; Wills, KL1
Abdullah, RA; Akbarali, H; Banks, ML; Cravatt, BF; Dewey, WL; Grim, TW; Lichtman, AH; Mustafa, MA; Niphakis, MJ; Poklis, JL; Wilkerson, JL; Wise, LE1
Campolongo, P; Gray, JM; Hill, MN; Leitl, KD; Morena, M; Vecchiarelli, HA1
Abdullah, RA; Cabrera, R; Cravatt, BF; Ghosh, S; Lichtman, AH; Maldonado, RL; Mustafa, M; Niphakis, MJ; Wilkerson, JL1
Barrett, DA; Couch, DG; Karwad, MA; Larvin, M; Lund, JN; O'Sullivan, SE; Sarmad, S; Theophilidou, E; Wright, KL1
Finn, DP; Flannery, LE; Henry, RJ; Kerr, DM; Roche, M1
Berardi, A; Campolongo, P; Colucci, P; Hill, MN; Morena, M; Palmery, M; Trezza, V1
Brodney, MA; Butler, CR; Cianfrogna, JA; da Silva, RG; Foley, TL; Fonseca, KR; Gilbert, AM; Harris, AR; Helal, CJ; Johnson, DS; McAllister, LA; Mente, S; Montgomery, JI; Nason, DM; Noell, S; O'Neil, SV; Pandit, J; Piro, JR; Rogers, BN; Samad, TA; Shaffer, CL; Uccello, DP; Webb, D1
Akirav, I; Fidelman, S; Hillard, CJ; Lange, R; Mizrachi Zer-Aviv, T1
Gong, DY; Hai, KR; Jiang, HX; Ke, BW; Liu, J; Ma, G; Yang, Z; Zhou, C1
Cavin, JB; Cravatt, BF; Hill, MN; Keenan, CM; Lau, DJ; Makriyannis, A; Morena, M; Sharkey, KA; Sticht, MA; Vemuri, VK1
Biernacki, M; Jastrząb, A; Malinowska, B; Remiszewski, P; Skrzydlewska, E; Timoszuk, M; Toczek, M1
Aliczki, M; Balogh, Z; Biro, L; Haller, J; Szente, L; Varga, ZK1
Alhouayek, M; Ameraoui, H; Bottemanne, P; Muccioli, GG; Paquot, A1
Alexander, SP; Callado, LF; Meana, JJ; Morentin, B; Muguruza, C1
Baindur, AN; Bass, CE; Cravatt, BF; Feja, M; Leigh, MPK; McGraw, JJ; Wakabayashi, KT1
Abohalaka, R; Bozkurt, TE; Nemutlu, E; Onder, SC; Sahin-Erdemli, I1
Omran, Z1

Reviews

1 review(s) available for carbamates and glyceryl 2-arachidonate

ArticleYear
Modulation of neuropathic-pain-related behaviour by the spinal endocannabinoid/endovanilloid system.
    Philosophical transactions of the Royal Society of London. Series B, Biological sciences, 2012, Dec-05, Volume: 367, Issue:1607

    Topics: Amides; Amidohydrolases; Animals; Arachidonic Acid; Arachidonic Acids; Behavior; Benzamides; Carbamates; Endocannabinoids; Enzyme Inhibitors; Ethanolamines; Glycerides; Humans; Microglia; Neuralgia; Palmitic Acids; Peripheral Nerve Injuries; Polyunsaturated Alkamides; Receptor, Cannabinoid, CB1; Spinal Cord Injuries; TRPV Cation Channels

2012

Other Studies

65 other study(ies) available for carbamates and glyceryl 2-arachidonate

ArticleYear
Cisplatin increases brain 2-arachidonoylglycerol (2-AG) and concomitantly reduces intestinal 2-AG and anandamide levels in the least shrew.
    Neuropharmacology, 2005, Volume: 49, Issue:4

    Topics: Analysis of Variance; Animals; Apomorphine; Arachidonic Acids; Benzamides; Benzyl Compounds; Brain; Carbamates; Cisplatin; Dopamine Agonists; Dose-Response Relationship, Drug; Drug Interactions; Endocannabinoids; Female; Glycerides; Intestinal Mucosa; Intestines; Male; Radiation-Sensitizing Agents; Serotonin; Shrews; Time Factors; Vomiting

2005
Endocannabinoids at the spinal level regulate, but do not mediate, nonopioid stress-induced analgesia.
    Neuropharmacology, 2006, Volume: 50, Issue:3

    Topics: Analgesia; Analysis of Variance; Animals; Arachidonic Acids; Behavior, Animal; Benzamides; Carbamates; Dose-Response Relationship, Drug; Drug Interactions; Endocannabinoids; Glycerides; Male; Mass Spectrometry; Pain Measurement; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rats; Rats, Sprague-Dawley; Reaction Time; Rimonabant; Serotonin; Spinal Cord; Stress, Psychological; Time Factors

2006
Endothelium-dependent metabolism by endocannabinoid hydrolases and cyclooxygenases limits vasorelaxation to anandamide and 2-arachidonoylglycerol.
    British journal of pharmacology, 2007, Volume: 150, Issue:5

    Topics: Amidohydrolases; Animals; Arachidonic Acids; Benzamides; Cannabinoid Receptor Modulators; Carbamates; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Endocannabinoids; Endothelium, Vascular; Enzyme Inhibitors; Glycerides; Hydrolases; In Vitro Techniques; Lectins; Lectins, C-Type; Male; Membrane Proteins; Mesenteric Artery, Superior; Organophosphonates; Polyunsaturated Alkamides; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Wistar; Receptors, Cell Surface; Vasodilation; Vasodilator Agents

2007
Visualization of 2-arachidonoylglycerol accumulation and cannabinoid CB1 receptor activity in rat brain cryosections by functional autoradiography.
    Journal of neurochemistry, 2007, Volume: 101, Issue:4

    Topics: Animals; Arachidonic Acids; Autoradiography; Benzamides; Binding, Competitive; Brain; Carbamates; Cryoultramicrotomy; Drug Interactions; Endocannabinoids; Enzyme Inhibitors; Glycerides; Guanosine 5'-O-(3-Thiotriphosphate); Male; Organophosphonates; Piperidines; Pyrazoles; Radiography; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Sulfones

2007
Interactions of cannabidiol with endocannabinoid signalling in hippocampal tissue.
    The European journal of neuroscience, 2007, Volume: 25, Issue:7

    Topics: Animals; Arachidonic Acids; Benzamides; Calcium; Cannabidiol; Cannabinoid Receptor Modulators; Carbamates; Cells, Cultured; Dronabinol; Endocannabinoids; Estrenes; Glutamic Acid; Glycerides; Hippocampus; Humans; Morpholines; Pertussis Toxin; Phosphodiesterase Inhibitors; Polyunsaturated Alkamides; Pyrazoles; Pyrrolidinones; Rats; Receptor, Cannabinoid, CB1; Signal Transduction

2007
Reduced anxiety-like behaviour induced by genetic and pharmacological inhibition of the endocannabinoid-degrading enzyme fatty acid amide hydrolase (FAAH) is mediated by CB1 receptors.
    Neuropharmacology, 2008, Volume: 54, Issue:1

    Topics: Amidohydrolases; Analysis of Variance; Animals; Anxiety; Arachidonic Acids; Behavior, Animal; Benzamides; Carbamates; Disease Models, Animal; Endocannabinoids; Glycerides; Male; Maze Learning; Mice; Mice, Inbred C57BL; Mice, Knockout; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant

2008
Changes in brain levels of N-acylethanolamines and 2-arachidonoylglycerol in focal cerebral ischemia in mice.
    Journal of neurochemistry, 2007, Volume: 103, Issue:5

    Topics: Analysis of Variance; Animals; Arachidonic Acids; Benzamides; Brain; Brain Infarction; Brain Ischemia; Carbamates; Disease Models, Animal; Endocannabinoids; Enzyme Inhibitors; Ethanolamines; Glycerides; Male; Mice; RNA, Messenger; Time Factors

2007
Inhibition of 2-arachidonoylglycerol catabolism modulates vasoconstriction of rat middle cerebral artery by the thromboxane mimetic, U-46619.
    British journal of pharmacology, 2007, Volume: 152, Issue:5

    Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Amidohydrolases; Aniline Compounds; Animals; Arachidonic Acid; Arachidonic Acids; Benzamides; Benzoxazines; Carbamates; Dose-Response Relationship, Drug; Drug Synergism; Endocannabinoids; Enzyme Inhibitors; Glycerides; In Vitro Techniques; Male; Middle Cerebral Artery; Morpholines; Naphthalenes; Nimodipine; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Rimonabant; Thromboxanes; Vasoconstriction; Vasoconstrictor Agents

2007
CB1 receptor-mediated control of the release of endocannabinoids (as assessed by microdialysis coupled with LC/MS) in the rat hypothalamus.
    The European journal of neuroscience, 2007, Volume: 26, Issue:12

    Topics: Amidohydrolases; Animals; Arachidonic Acids; Benzamides; Benzoxazines; Cannabinoid Receptor Modulators; Cannabinoids; Carbamates; Chromatography, Liquid; Endocannabinoids; Extracellular Fluid; Glycerides; Hypothalamus; Male; Microdialysis; Morpholines; Naphthalenes; Piperidines; Polyunsaturated Alkamides; Potassium; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Rimonabant; Tandem Mass Spectrometry

2007
A comprehensive profile of brain enzymes that hydrolyze the endocannabinoid 2-arachidonoylglycerol.
    Chemistry & biology, 2007, Volume: 14, Issue:12

    Topics: Animals; Arachidonic Acids; Benzamides; Biotin; Brain; Carbamates; Catalysis; Chlorocebus aethiops; COS Cells; Endocannabinoids; Enzyme Inhibitors; Glycerides; Hydrolases; Lactones; Membrane Proteins; Mice; Mice, Inbred C57BL; Monoacylglycerol Lipases; Organophosphorus Compounds; Orlistat; Proteomics; Subcellular Fractions; Transfection

2007
Does the hydrolysis of 2-arachidonoylglycerol regulate its cellular uptake?
    Pharmacological research, 2008, Volume: 58, Issue:1

    Topics: Amidohydrolases; Animals; Arachidonic Acids; Benzamides; Biphenyl Compounds; Cannabinoid Receptor Modulators; Carbamates; Cell Line, Tumor; Endocannabinoids; Glycerides; Humans; Hydrolysis; Polyunsaturated Alkamides

2008
Cannabinoids inhibit HIV-1 Gp120-mediated insults in brain microvascular endothelial cells.
    Journal of immunology (Baltimore, Md. : 1950), 2008, Nov-01, Volume: 181, Issue:9

    Topics: AIDS Dementia Complex; Amidohydrolases; Anti-HIV Agents; Arachidonic Acids; Benzamides; Blood-Brain Barrier; Brain; Cannabinoid Receptor Modulators; Carbamates; Cell Line; Coculture Techniques; Endocannabinoids; Endothelium, Vascular; Glycerides; HIV Envelope Protein gp120; HIV-1; Humans; Microcirculation; Receptor, Cannabinoid, CB1

2008
Depolarizing GABAergic synaptic input triggers endocannabinoid-mediated retrograde synaptic signaling.
    Synapse (New York, N.Y.), 2009, Volume: 63, Issue:8

    Topics: Aniline Compounds; Animals; Animals, Newborn; Arachidonic Acids; Benzamides; Bicuculline; Biophysics; Calcium; Calcium Signaling; Cannabinoid Receptor Antagonists; Cannabinoid Receptor Modulators; Carbamates; Cerebellum; Electric Stimulation; Endocannabinoids; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Fluoresceins; GABA Agonists; GABA Antagonists; gamma-Aminobutyric Acid; Glycerides; In Vitro Techniques; Inhibitory Postsynaptic Potentials; Lactones; Mice; Muscimol; Orlistat; Patch-Clamp Techniques; Piperidines; Purkinje Cells; Pyrazoles; Quinoxalines; Rimonabant; Signal Transduction; Synapses; Valine

2009
Blockade of endocannabinoid-degrading enzymes attenuates neuropathic pain.
    The Journal of pharmacology and experimental therapeutics, 2009, Volume: 330, Issue:3

    Topics: Amidohydrolases; Analgesics, Non-Narcotic; Animals; Arachidonic Acids; Benzamides; Benzodioxoles; Cannabinoid Receptor Modulators; Carbamates; Cold Temperature; Endocannabinoids; Enzyme Inhibitors; Glycerides; Hyperalgesia; Male; Mice; Mice, Inbred C57BL; Monoacylglycerol Lipases; Narcotic Antagonists; Pain; Pain Measurement; Peripheral Nervous System Diseases; Piperidines; Polyunsaturated Alkamides; Pyridines; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; TRPV Cation Channels

2009
Blockade of 2-arachidonoylglycerol hydrolysis by selective monoacylglycerol lipase inhibitor 4-nitrophenyl 4-(dibenzo[d][1,3]dioxol-5-yl(hydroxy)methyl)piperidine-1-carboxylate (JZL184) Enhances retrograde endocannabinoid signaling.
    The Journal of pharmacology and experimental therapeutics, 2009, Volume: 331, Issue:2

    Topics: Amidohydrolases; Animals; Arachidonic Acids; Benzamides; Benzodioxoles; Cannabinoid Receptor Modulators; Carbamates; Electrophysiology; Endocannabinoids; Enzyme Inhibitors; Glycerides; Hydrolysis; Lipase; Mice; Mice, Inbred C57BL; Mice, Knockout; Patch-Clamp Techniques; Piperidines; Purkinje Cells; Pyramidal Cells; Rats; Rats, Sprague-Dawley; Signal Transduction; Synapses

2009
Effect of nitric oxide donors on membrane tritium accumulation of endocannabinoids and related endogenous lipids.
    European journal of pharmacology, 2009, Oct-25, Volume: 621, Issue:1-3

    Topics: Amides; Animals; Arachidonic Acids; Benzamides; Cannabinoid Receptor Modulators; Carbamates; Cell Line; Cell Membrane; Cyclic N-Oxides; Endocannabinoids; Ethanolamines; Free Radical Scavengers; Glycerides; Imidazoles; Lipid Metabolism; Mice; Nitric Oxide; Nitric Oxide Donors; Palmitic Acids; Polyunsaturated Alkamides; Rats; Signal Transduction; Tritium

2009
Metabolism of 2-acylglycerol in rabbit and human platelets. Involvement of monoacylglycerol lipase and fatty acid amide hydrolase.
    Platelets, 2009, Volume: 20, Issue:6

    Topics: Amidohydrolases; Animals; Arachidonic Acids; Benzamides; Blood Platelets; Carbamates; Endocannabinoids; Enzyme Inhibitors; Glycerides; Glycerol; Humans; Hydrogen-Ion Concentration; Hydrolysis; Immunoblotting; Monoacylglycerol Lipases; Palmitates; Rabbits; Subcellular Fractions; Tritium

2009
Dual blockade of FAAH and MAGL identifies behavioral processes regulated by endocannabinoid crosstalk in vivo.
    Proceedings of the National Academy of Sciences of the United States of America, 2009, Dec-01, Volume: 106, Issue:48

    Topics: Amidohydrolases; Animals; Arachidonic Acids; Cannabinoid Receptor Modulators; Carbamates; Carboxylic Ester Hydrolases; Endocannabinoids; Glycerides; Mice; Molecular Structure; Monoacylglycerol Lipases; Motor Activity; Pain Measurement; Piperazines; Piperidines; Polyunsaturated Alkamides

2009
Transient receptor potential vanilloid 1 channels control acetylcholine/2-arachidonoylglicerol coupling in the striatum.
    Neuroscience, 2010, May-19, Volume: 167, Issue:3

    Topics: Acetylcholine; Amidohydrolases; Animals; Arachidonic Acids; Benzamides; Cannabinoid Receptor Modulators; Capsaicin; Carbamates; Corpus Striatum; Endocannabinoids; Enzyme Inhibitors; gamma-Aminobutyric Acid; Glycerides; Inhibitory Postsynaptic Potentials; Mice; Mice, Inbred C57BL; Mice, Knockout; Muscarinic Agonists; Neural Inhibition; Organ Culture Techniques; Polyunsaturated Alkamides; Receptor, Metabotropic Glutamate 5; Receptor, Muscarinic M1; Receptors, Metabotropic Glutamate; Sensory System Agents; Synaptic Transmission; TRPV Cation Channels

2010
Reduction in endocannabinoid tone is a homeostatic mechanism for specific inhibitory synapses.
    Nature neuroscience, 2010, Volume: 13, Issue:5

    Topics: Agatoxins; Animals; Arachidonic Acids; Benzamides; Benzoxazines; Biophysics; Calcium; Calcium Channel Blockers; Cannabinoid Receptor Modulators; Carbamates; Conotoxins; Dose-Response Relationship, Drug; Down-Regulation; Drug Interactions; Electric Stimulation; Endocannabinoids; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; gamma-Aminobutyric Acid; Glycerides; Hippocampus; Homeostasis; In Vitro Techniques; Inhibitory Postsynaptic Potentials; Morpholines; Naphthalenes; Nerve Net; Neural Inhibition; Neurons; Patch-Clamp Techniques; Piperidines; Polyamines; Polyunsaturated Alkamides; Pyrazoles; Rats; Receptor, Cannabinoid, CB1; Rimonabant; Sodium Channel Blockers; Synapses; Tetrodotoxin

2010
Hydrolysis of 2-arachidonoylglycerol in Tetrahymena thermophila. Identification and partial characterization of a Monoacylglycerol Lipase-like enzyme.
    European journal of protistology, 2010, Volume: 46, Issue:4

    Topics: Amidohydrolases; Arachidonic Acids; Benzamides; Carbamates; Cell Membrane; Cytosol; Endocannabinoids; Enzyme Inhibitors; Glycerides; Hydrogen-Ion Concentration; Hydrolysis; Kinetics; Molecular Weight; Monoacylglycerol Lipases; Palmitates; Protozoan Proteins; Tetrahymena thermophila

2010
Differential role of anandamide and 2-arachidonoylglycerol in memory and anxiety-like responses.
    Biological psychiatry, 2011, Sep-01, Volume: 70, Issue:5

    Topics: Amidohydrolases; Analgesics; Animals; Anti-Anxiety Agents; Arachidonic Acids; Benzamides; Benzodioxoles; Cannabinoid Receptor Antagonists; Carbamates; Drug Tolerance; Endocannabinoids; Glycerides; Hippocampus; Maze Learning; Mice; Mice, Inbred Strains; Mice, Knockout; Monoacylglycerol Lipases; Pain Measurement; Piperidines; Polyunsaturated Alkamides; Receptors, Cannabinoid; Recognition, Psychology; TOR Serine-Threonine Kinases

2011
Dual inhibition of MAGL and type II topoisomerase by N-phenylmaleimides as a potential strategy to reduce neuroblastoma cell growth.
    European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 2012, Feb-14, Volume: 45, Issue:3

    Topics: Antineoplastic Agents; Arachidonic Acids; Benzodioxoles; Cannabinoid Receptor Modulators; Carbamates; Cell Proliferation; DNA Topoisomerases, Type II; Endocannabinoids; Etoposide; Glycerides; Humans; Maleimides; Monoacylglycerol Lipases; Neuroblastoma; Oxadiazoles; Piperidines; Topoisomerase II Inhibitors; Tumor Cells, Cultured

2012
Endocannabinoid regulation of acute and protracted nicotine withdrawal: effect of FAAH inhibition.
    PloS one, 2011, Volume: 6, Issue:11

    Topics: Acute Disease; Amidohydrolases; Animals; Anxiety; Arachidonic Acids; Benzamides; Brain; Cannabinoid Receptor Modulators; Carbamates; Cotinine; Endocannabinoids; Glycerides; Implants, Experimental; Locomotion; Male; Maze Learning; Nicotine; Polyunsaturated Alkamides; Rats; Rats, Wistar; Substance Withdrawal Syndrome; Tobacco Use Cessation Devices; Weight Gain

2011
Prefrontal cortical anandamide signaling coordinates coping responses to stress through a serotonergic pathway.
    European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology, 2012, Volume: 22, Issue:9

    Topics: Action Potentials; Adaptation, Psychological; Animals; Arachidonic Acids; Benzamides; Cannabinoid Receptor Antagonists; Carbamates; Endocannabinoids; Enzyme Inhibitors; Fenclonine; Glycerides; Male; Microinjections; Piperidines; Polyunsaturated Alkamides; Prefrontal Cortex; Pyrazoles; Raphe Nuclei; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Serotonergic Neurons; Signal Transduction; Stress, Psychological

2012
Highly selective inhibitors of monoacylglycerol lipase bearing a reactive group that is bioisosteric with endocannabinoid substrates.
    Chemistry & biology, 2012, May-25, Volume: 19, Issue:5

    Topics: Amidohydrolases; Animals; Arachidonic Acids; Cannabinoid Receptor Modulators; Carbamates; Endocannabinoids; Enzyme Inhibitors; Glycerides; HEK293 Cells; Humans; Mice; Mice, Inbred C57BL; Models, Molecular; Monoacylglycerol Lipases; Polyunsaturated Alkamides; Rats; Rats, Wistar

2012
The endocannabinoid, anandamide, augments Notch-1 signaling in cultured cortical neurons exposed to amyloid-β and in the cortex of aged rats.
    The Journal of biological chemistry, 2012, Oct-05, Volume: 287, Issue:41

    Topics: Aging; Alzheimer Disease; Amyloid beta-Peptides; Amyloid Precursor Protein Secretases; Animals; Arachidonic Acids; Benzamides; Carbamates; Cells, Cultured; Cerebral Cortex; Endocannabinoids; Gene Expression Regulation, Enzymologic; Glycerides; Hippocampus; Male; Membrane Glycoproteins; Neurons; Peptide Fragments; Polyunsaturated Alkamides; Rats; Rats, Wistar; Receptor, Notch1; Signal Transduction; Up-Regulation

2012
Quantitative LC-MS/MS analysis of arachidonoyl amino acids in mouse brain with treatment of FAAH inhibitor.
    Analytical biochemistry, 2013, Jan-15, Volume: 432, Issue:2

    Topics: Amidohydrolases; Amino Acids; Animals; Arachidonic Acids; Benzamides; Brain; Carbamates; Chromatography, High Pressure Liquid; Endocannabinoids; Enzyme Inhibitors; gamma-Aminobutyric Acid; Glycerides; Mice; Polyunsaturated Alkamides; Tandem Mass Spectrometry

2013
Alterations in endocannabinoid tone following chemotherapy-induced peripheral neuropathy: effects of endocannabinoid deactivation inhibitors targeting fatty-acid amide hydrolase and monoacylglycerol lipase in comparison to reference analgesics following c
    Pharmacological research, 2013, Volume: 67, Issue:1

    Topics: Amidohydrolases; Analgesics; Animals; Antineoplastic Agents; Arachidonic Acids; Benzamides; Benzodioxoles; Cannabinoids; Carbamates; Cisplatin; Endocannabinoids; Enzyme Inhibitors; Ganglia, Spinal; Glycerides; Hyperalgesia; Lipid Metabolism; Male; Monoacylglycerol Lipases; Peripheral Nervous System Diseases; Piperidines; Polyunsaturated Alkamides; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; RNA, Messenger; Spinal Cord; TRPV Cation Channels

2013
Selective inhibition of alpha/beta-hydrolase domain 6 attenuates neurodegeneration, alleviates blood brain barrier breakdown, and improves functional recovery in a mouse model of traumatic brain injury.
    Journal of neurotrauma, 2013, Apr-01, Volume: 30, Issue:7

    Topics: Animals; Arachidonic Acids; Biphenyl Compounds; Blood-Brain Barrier; Blotting, Western; Brain Injuries; Carbamates; Disease Models, Animal; Endocannabinoids; Enzyme Inhibitors; Glycerides; Immunohistochemistry; Male; Mice; Mice, Inbred C57BL; Monoacylglycerol Lipases; Nerve Degeneration; Recovery of Function

2013
Full inhibition of spinal FAAH leads to TRPV1-mediated analgesic effects in neuropathic rats and possible lipoxygenase-mediated remodeling of anandamide metabolism.
    PloS one, 2013, Volume: 8, Issue:4

    Topics: Amides; Amidohydrolases; Analgesia; Animals; Arachidonate 15-Lipoxygenase; Arachidonic Acids; Benzamides; Calcium Signaling; Carbamates; Diterpenes; Endocannabinoids; Ethanolamines; Flavanones; Glycerides; HEK293 Cells; Humans; Hyperalgesia; Injections, Spinal; Lipoxygenase Inhibitors; Male; Neuralgia; Oleic Acids; Palmitic Acids; Polyunsaturated Alkamides; Posterior Horn Cells; Rats; Rats, Wistar; Sciatic Nerve; Spinal Cord; TRPV Cation Channels

2013
Attenuation of anticipatory nausea in a rat model of contextually elicited conditioned gaping by enhancement of the endocannabinoid system.
    Psychopharmacology, 2014, Volume: 231, Issue:3

    Topics: Amidohydrolases; Animals; Anticipation, Psychological; Arachidonic Acids; Brain; Cannabinoid Receptor Antagonists; Carbamates; Endocannabinoids; Enzyme Inhibitors; Glycerides; Indoles; Lithium Chloride; Male; Monoacylglycerol Lipases; Motor Activity; Nausea; Oleic Acids; Piperazines; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Rimonabant

2014
Implication of the anti-inflammatory bioactive lipid prostaglandin D2-glycerol ester in the control of macrophage activation and inflammation by ABHD6.
    Proceedings of the National Academy of Sciences of the United States of America, 2013, Oct-22, Volume: 110, Issue:43

    Topics: Animals; Anti-Inflammatory Agents; Arachidonic Acids; Biphenyl Compounds; Carbamates; Cell Line; Cells, Cultured; Cyclooxygenase 2; Endocannabinoids; Enzyme Inhibitors; Enzyme-Linked Immunosorbent Assay; Esters; Female; Gene Expression; Glycerides; Glycerol; Inflammation; Interleukin-1beta; Intramolecular Oxidoreductases; Lipocalins; Lipopolysaccharides; Macrophage Activation; Macrophages; Male; Mice; Mice, Inbred C57BL; Monoacylglycerol Lipases; Prostaglandin D2; Reverse Transcriptase Polymerase Chain Reaction

2013
Elevation of endogenous anandamide impairs LTP, learning, and memory through CB1 receptor signaling in mice.
    Hippocampus, 2014, Volume: 24, Issue:7

    Topics: Amidohydrolases; Animals; Arachidonic Acids; Benzamides; Calcium-Calmodulin-Dependent Protein Kinase Type 4; Carbamates; Cyclic AMP Response Element-Binding Protein; Endocannabinoids; Glycerides; Learning; Long-Term Potentiation; Male; MAP Kinase Signaling System; Maze Learning; Memory; Mice; Mice, Inbred C57BL; Mice, Knockout; Phosphorylation; Polyunsaturated Alkamides; Protein Processing, Post-Translational; Receptor, Cannabinoid, CB1; Spatial Memory

2014
Antidepressants and changes in concentration of endocannabinoids and N-acylethanolamines in rat brain structures.
    Neurotoxicity research, 2014, Volume: 26, Issue:2

    Topics: Acetylcysteine; Amides; Amidohydrolases; Animals; Antidepressive Agents; Arachidonic Acids; Benzamides; Brain; Carbamates; Citalopram; Endocannabinoids; Enzyme Inhibitors; Ethanolamines; Expectorants; Glycerides; Imipramine; Male; Oleic Acids; Palmitic Acids; Polyunsaturated Alkamides; Rats, Wistar; Thiazepines

2014
Prior stimulation of the endocannabinoid system prevents methamphetamine-induced dopaminergic neurotoxicity in the striatum through activation of CB2 receptors.
    Neuropharmacology, 2014, Volume: 87

    Topics: Animals; Arachidonic Acids; Benzamides; Benzodioxoles; Cannabinoid Receptor Modulators; Carbamates; Central Nervous System Stimulants; Dronabinol; Endocannabinoids; Enzyme Inhibitors; Glycerides; Male; Methamphetamine; Mice, Inbred C57BL; Neostriatum; Neurotoxicity Syndromes; Piperidines; Polyunsaturated Alkamides; Random Allocation; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Tumor Necrosis Factor-alpha; Tyrosine 3-Monooxygenase

2014
Increased angiotensin II contraction of the uterine artery at early gestation in a transgenic model of hypertensive pregnancy is reduced by inhibition of endocannabinoid hydrolysis.
    Hypertension (Dallas, Tex. : 1979), 2014, Volume: 64, Issue:3

    Topics: Amidohydrolases; Angiotensin II; Animals; Arachidonic Acids; Benzamides; Benzodioxoles; Blood Pressure; Carbamates; Disease Models, Animal; Endocannabinoids; Female; Glycerides; Humans; Hydrolysis; Hypertension, Pregnancy-Induced; Male; Monoglycerides; Piperidines; Polyunsaturated Alkamides; Pregnancy; Pregnancy, Animal; Rats; Rats, Sprague-Dawley; Rats, Transgenic; Uterine Artery; Vasoconstriction

2014
Endocannabinoid modulation by FAAH and monoacylglycerol lipase within the analgesic circuitry of the periaqueductal grey.
    British journal of pharmacology, 2014, Volume: 171, Issue:23

    Topics: Amidohydrolases; Animals; Arachidonic Acids; Benzamides; Benzodioxoles; Carbamates; Endocannabinoids; Female; Glycerides; In Vitro Techniques; Inhibitory Postsynaptic Potentials; Male; Monoacylglycerol Lipases; Neurons; Pain; Periaqueductal Gray; Piperidines; Polyunsaturated Alkamides; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Synaptic Transmission

2014
Endocannabinoid degradation inhibition improves neurobehavioral function, blood-brain barrier integrity, and neuroinflammation following mild traumatic brain injury.
    Journal of neurotrauma, 2015, Mar-01, Volume: 32, Issue:5

    Topics: Animals; Arachidonic Acids; Benzamides; Benzodioxoles; Blood-Brain Barrier; Blotting, Western; Brain Injuries; Carbamates; Disease Models, Animal; Endocannabinoids; Glycerides; Immunohistochemistry; Inflammation; Male; Neuroprotective Agents; Piperidines; Polyunsaturated Alkamides; Rats; Rats, Sprague-Dawley; Real-Time Polymerase Chain Reaction; Recovery of Function

2015
Endogenous cannabinoid release within prefrontal-limbic pathways affects memory consolidation of emotional training.
    Proceedings of the National Academy of Sciences of the United States of America, 2014, Dec-23, Volume: 111, Issue:51

    Topics: Amidohydrolases; Animals; Arachidonic Acids; Avoidance Learning; Benzamides; Carbamates; Emotions; Endocannabinoids; Glycerides; Limbic System; Memory; Polyunsaturated Alkamides; Prefrontal Cortex; Rats; Receptor, Cannabinoid, CB1

2014
Selective blockade of the hydrolysis of the endocannabinoid 2-arachidonoylglycerol impairs learning and memory performance while producing antinociceptive activity in rodents.
    Scientific reports, 2015, Jan-06, Volume: 5

    Topics: Acetylcholine; Administration, Oral; Analgesics; Animals; Arachidonic Acids; Binding Sites; Brain; Cannabinoid Receptor Antagonists; Carbamates; Chromatography, High Pressure Liquid; Crystallography, X-Ray; Disease Models, Animal; Electric Stimulation; Endocannabinoids; Enzyme Inhibitors; Glycerides; Hippocampus; Humans; Hydrolysis; In Vitro Techniques; Learning; Long-Term Potentiation; Mass Spectrometry; Memory, Short-Term; Mice; Mice, Inbred C57BL; Mice, SCID; Monoacylglycerol Lipases; Pain; Piperidines; Protein Structure, Tertiary; Pyrazoles; Rimonabant; Seizures; Sulfonamides

2015
Opposite control of frontocortical 2-arachidonoylglycerol turnover rate by cannabinoid type-1 receptors located on glutamatergic neurons and on astrocytes.
    Journal of neurochemistry, 2015, Volume: 133, Issue:1

    Topics: Amidohydrolases; Animals; Arachidonic Acids; Astrocytes; Carbamates; Endocannabinoids; Enzyme Inhibitors; Glutamic Acid; Glycerides; Hippocampus; Kinetics; Male; Mice; Mice, Knockout; Neurons; Piperazines; Prefrontal Cortex; Receptor, Cannabinoid, CB1

2015
Phenotypic assessment of THC discriminative stimulus properties in fatty acid amide hydrolase knockout and wildtype mice.
    Neuropharmacology, 2015, Volume: 93

    Topics: Amidohydrolases; Analysis of Variance; Animals; Arachidonic Acids; Benzodioxoles; Brain; Cannabinoid Receptor Agonists; Cannabinoid Receptor Antagonists; Carbamates; Discrimination, Psychological; Dose-Response Relationship, Drug; Dronabinol; Endocannabinoids; Enzyme Inhibitors; Glycerides; Male; Mice; Mice, Knockout; Piperazines; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rimonabant

2015
Distinct roles of the endocannabinoids anandamide and 2-arachidonoylglycerol in social behavior and emotionality at different developmental ages in rats.
    European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology, 2015, Volume: 25, Issue:8

    Topics: Aging; Animals; Anxiety; Arachidonic Acids; Brain; Cannabinoid Receptor Modulators; Carbamates; Endocannabinoids; Exploratory Behavior; Glycerides; Male; Piperazines; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rats, Sprague-Dawley; Rimonabant; Social Behavior

2015
Inhibition of FAAH confers increased stem cell migration via PPARα.
    Journal of lipid research, 2015, Volume: 56, Issue:10

    Topics: Adipose Tissue; Amides; Amidohydrolases; Arachidonic Acids; Benzamides; Carbamates; Cell Movement; Cells, Cultured; Endocannabinoids; Enzyme Inhibitors; Ethanolamines; Glycerides; Humans; Mesenchymal Stem Cells; Oleic Acids; Palmitic Acids; Polyunsaturated Alkamides; PPAR alpha; Receptor, Cannabinoid, CB1; Serotonin

2015
Training-Associated Emotional Arousal Shapes Endocannabinoid Modulation of Spatial Memory Retrieval in Rats.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2015, Oct-14, Volume: 35, Issue:41

    Topics: Animals; Arachidonic Acids; Arousal; Benzamides; Benzoxazines; Calcium Channel Blockers; Cannabinoid Receptor Agonists; Carbamates; Corticosterone; Dose-Response Relationship, Drug; Emotions; Endocannabinoids; Enzyme Inhibitors; Glycerides; Hippocampus; Male; Maze Learning; Mental Recall; Morpholines; Naphthalenes; Rats; Rats, Sprague-Dawley; Spatial Learning; Stress, Psychological; Temperature

2015
Endocannabinoid regulation of nausea is mediated by 2-arachidonoylglycerol (2-AG) in the rat visceral insular cortex.
    Neuropharmacology, 2016, Volume: 102

    Topics: Animals; Arachidonic Acids; Carbamates; Cerebral Cortex; Endocannabinoids; Glycerides; Nausea; Neurons; Piperazines; Proto-Oncogene Proteins c-fos; Rats; Receptor, Cannabinoid, CB1

2016
Double Dissociation of Monoacylglycerol Lipase Inhibition and CB1 Antagonism in the Central Amygdala, Basolateral Amygdala, and the Interoceptive Insular Cortex on the Affective Properties of Acute Naloxone-Precipitated Morphine Withdrawal in Rats.
    Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2016, Volume: 41, Issue:7

    Topics: Amygdala; Analysis of Variance; Animals; Arachidonic Acids; Cannabinoid Receptor Agonists; Carbamates; Cerebral Cortex; Conditioning, Operant; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Routes; Endocannabinoids; Glycerides; Male; Monoacylglycerol Lipases; Morphine; Naloxone; Narcotic Antagonists; Narcotics; Rats; Rats, Sprague-Dawley; Substance Withdrawal Syndrome; Succinimides

2016
The Selective Monoacylglycerol Lipase Inhibitor MJN110 Produces Opioid-Sparing Effects in a Mouse Neuropathic Pain Model.
    The Journal of pharmacology and experimental therapeutics, 2016, Volume: 357, Issue:1

    Topics: Analgesics, Opioid; Animals; Arachidonic Acids; Behavior, Animal; Carbamates; Constriction, Pathologic; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Synergism; Endocannabinoids; Enzyme Inhibitors; Glycerides; Hyperalgesia; Male; Mice; Mice, Inbred C57BL; Monoacylglycerol Lipases; Morphine; Neuralgia; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Receptors, Opioid, mu; Succinimides

2016
Emotional arousal state influences the ability of amygdalar endocannabinoid signaling to modulate anxiety.
    Neuropharmacology, 2016, Volume: 111

    Topics: Animals; Anxiety; Arachidonic Acids; Arousal; Basolateral Nuclear Complex; Benzamides; Cannabinoid Receptor Agonists; Carbamates; Corticosterone; Emotions; Endocannabinoids; Epinephrine; Glycerides; Male; Polyunsaturated Alkamides; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Signal Transduction

2016
The endocannabinoid hydrolysis inhibitor SA-57: Intrinsic antinociceptive effects, augmented morphine-induced antinociception, and attenuated heroin seeking behavior in mice.
    Neuropharmacology, 2017, 03-01, Volume: 114

    Topics: Acetamides; Analgesics; Analgesics, Opioid; Animals; Arachidonic Acid; Arachidonic Acids; Carbamates; Carrageenan; Dose-Response Relationship, Drug; Drug-Seeking Behavior; Endocannabinoids; Glycerides; Heroin; Hydrolysis; Hyperalgesia; Inflammation; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Morphine; Neuralgia; Polyunsaturated Alkamides; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Sciatic Nerve; Self Administration

2017
The role of CB
    FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2017, Volume: 31, Issue:8

    Topics: Amidohydrolases; Arachidonic Acids; Benzamides; Benzodioxoles; Caco-2 Cells; Carbamates; Colorectal Neoplasms; Cytokines; Electric Impedance; Endocannabinoids; Gene Expression Regulation; Glycerides; Humans; Inflammation; Intestinal Mucosa; Intestines; Monoacylglycerol Lipases; Oxygen Consumption; Permeability; Piperidines; Polyunsaturated Alkamides; Receptor, Cannabinoid, CB1; Tissue Culture Techniques

2017
FAAH, but not MAGL, inhibition modulates acute TLR3-induced neuroimmune signaling in the rat, independent of sex.
    Journal of neuroscience research, 2018, Volume: 96, Issue:6

    Topics: Amides; Amidohydrolases; Animals; Arachidonic Acids; Body Temperature; Carbamates; Chemokine CXCL10; Corticosterone; Endocannabinoids; Estradiol; Ethanolamines; Female; Glycerides; Immunologic Factors; Interferons; Male; Monoacylglycerol Lipases; NF-kappa B; Oleic Acids; Palmitic Acids; Poly I-C; Polyunsaturated Alkamides; Rats; Rats, Sprague-Dawley; Sex Factors; Signal Transduction; Succinimides; Toll-Like Receptor 3

2018
Enhancing Endocannabinoid Neurotransmission Augments The Efficacy of Extinction Training and Ameliorates Traumatic Stress-Induced Behavioral Alterations in Rats.
    Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2018, Volume: 43, Issue:6

    Topics: Amidohydrolases; Animals; Arachidonic Acids; Benzamides; Benzodioxoles; Benzoxazines; Cannabinoid Receptor Modulators; Carbamates; Disease Models, Animal; Electroshock; Endocannabinoids; Extinction, Psychological; Glycerides; Male; Morpholines; Naphthalenes; Piperidines; Psychotropic Drugs; Rats, Sprague-Dawley; Social Isolation; Stress Disorders, Post-Traumatic; Synaptic Transmission

2018
Discovery of Trifluoromethyl Glycol Carbamates as Potent and Selective Covalent Monoacylglycerol Lipase (MAGL) Inhibitors for Treatment of Neuroinflammation.
    Journal of medicinal chemistry, 2018, 04-12, Volume: 61, Issue:7

    Topics: Amidohydrolases; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acids; Biomarkers; Brain Chemistry; Carbamates; Dogs; Drug Design; Drug Discovery; Endocannabinoids; Enzyme Inhibitors; Glycerides; Humans; Macaca mulatta; Models, Molecular; Monoacylglycerol Lipases; Neuritis; Rats; Rats, Wistar; Structure-Activity Relationship

2018
Chronic treatment with URB597 ameliorates post-stress symptoms in a rat model of PTSD.
    European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology, 2018, Volume: 28, Issue:5

    Topics: Amidohydrolases; Animals; Arachidonic Acids; Basolateral Nuclear Complex; Benzamides; Benzoxazines; CA1 Region, Hippocampal; Cannabinoid Receptor Antagonists; Carbamates; Dose-Response Relationship, Drug; Electric Stimulation; Endocannabinoids; Extinction, Psychological; Glycerides; Male; Morpholines; Naphthalenes; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rats; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Reflex, Startle; Stress Disorders, Post-Traumatic

2018
Inhibition of Fatty Acid Amide Hydrolase Improves Depressive-Like Behaviors Independent of Its Peripheral Antinociceptive Effects in a Rat Model of Neuropathic Pain.
    Anesthesia and analgesia, 2019, Volume: 129, Issue:2

    Topics: Amidohydrolases; Animals; Arachidonic Acids; Behavior, Animal; Benzamides; Carbamates; Depression; Disease Models, Animal; Endocannabinoids; Enzyme Inhibitors; Feeding Behavior; Glycerides; Hippocampus; Locomotion; Male; Neuralgia; Neurogenesis; Pain Threshold; Polyunsaturated Alkamides; Rats, Wistar; Receptor, Cannabinoid, CB1; Signal Transduction; Swimming

2019
Endocannabinoid regulation of homeostatic feeding and stress-induced alterations in food intake in male rats.
    British journal of pharmacology, 2019, Volume: 176, Issue:10

    Topics: Amidohydrolases; Animals; Anorexia; Arachidonic Acids; Carbamates; Duodenum; Eating; Endocannabinoids; Glycerides; Homeostasis; Jejunum; Male; Monoacylglycerol Lipases; Polyunsaturated Alkamides; Rats, Sprague-Dawley; Stress, Psychological; Succinimides

2019
Hypertension and chronic inhibition of endocannabinoid degradation modify the endocannabinoid system and redox balance in rat heart and plasma.
    Prostaglandins & other lipid mediators, 2018, Volume: 138

    Topics: Amidohydrolases; Animals; Arachidonic Acids; Benzamides; Carbamates; Desoxycorticosterone Acetate; Endocannabinoids; Glycerides; Heart; Hypertension; Male; Myocardium; Oxidation-Reduction; Oxidative Stress; Polyunsaturated Alkamides; Rats, Inbred SHR; Rats, Wistar; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2

2018
Endocannabinoid interactions in the regulation of acquisition of contextual conditioned fear.
    Progress in neuro-psychopharmacology & biological psychiatry, 2019, 03-02, Volume: 90

    Topics: Animals; Arachidonic Acids; Benzamides; Benzodioxoles; Brain; Carbamates; Central Nervous System Agents; Conditioning, Psychological; Endocannabinoids; Fear; Glycerides; Male; Motor Activity; Nociception; Piperidines; Polyunsaturated Alkamides; Random Allocation; Rats, Wistar

2019
The α/β-hydrolase domain 6 inhibitor WWL70 decreases endotoxin-induced lung inflammation in mice, potential contribution of 2-arachidonoylglycerol, and lysoglycerophospholipids.
    FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2019, Volume: 33, Issue:6

    Topics: Animals; Arachidonic Acids; Biphenyl Compounds; Bronchoalveolar Lavage Fluid; Carbamates; Endocannabinoids; Endotoxins; Enzyme Inhibitors; Glycerides; Glycerophospholipids; Macrophages, Alveolar; Male; Mice; Monoacylglycerol Lipases; Neutrophils; Pneumonia; Substrate Specificity

2019
Endocannabinoid system imbalance in the postmortem prefrontal cortex of subjects with schizophrenia.
    Journal of psychopharmacology (Oxford, England), 2019, Volume: 33, Issue:9

    Topics: Adult; Amidohydrolases; Arachidonic Acids; Carbamates; Endocannabinoids; Female; Glycerides; Humans; Male; Middle Aged; Monoacylglycerol Lipases; Prefrontal Cortex; Receptor, Cannabinoid, CB1; Schizophrenia

2019
The novel MAGL inhibitor MJN110 enhances responding to reward-predictive incentive cues by activation of CB1 receptors.
    Neuropharmacology, 2020, 01-01, Volume: 162

    Topics: Animals; Arachidonic Acids; Behavior, Animal; Carbamates; Conditioning, Operant; Cues; Dopaminergic Neurons; Endocannabinoids; GABAergic Neurons; Glycerides; Male; Monoacylglycerol Lipases; Motivation; Neural Inhibition; Rats; Rats, Long-Evans; Receptor, Cannabinoid, CB1; Reward; Rimonabant; Succinimides; Sucrose; Ventral Tegmental Area

2020
The effects of fatty acid amide hydrolase and monoacylglycerol lipase inhibitor treatments on lipopolysaccharide-induced airway inflammation in mice.
    Pulmonary pharmacology & therapeutics, 2020, Volume: 62

    Topics: Amidohydrolases; Animals; Arachidonic Acids; Benzamides; Benzodioxoles; Carbamates; Cytokines; Endocannabinoids; Glycerides; Inflammation; Lipopolysaccharides; Lung; Male; Mice; Monoacylglycerol Lipases; Piperidines; Pneumonia; Polyunsaturated Alkamides; Respiratory Hypersensitivity

2020
New Disulfiram Derivatives as MAGL-Selective Inhibitors.
    Molecules (Basel, Switzerland), 2021, May-30, Volume: 26, Issue:11

    Topics: Amidohydrolases; Arachidonic Acids; Carbamates; Disulfiram; Endocannabinoids; Enzyme Inhibitors; Glycerides; Humans; Hydrolysis; Monoacylglycerol Lipases; Monoglycerides; Structure-Activity Relationship

2021